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https://www.readbyqxmd.com/read/28223498/attenuated-pfspz-vaccine-induces-strain-transcending-t-cells-and-durable-protection-against-heterologous-controlled-human-malaria-infection
#1
Kirsten E Lyke, Andrew S Ishizuka, Andrea A Berry, Sumana Chakravarty, Adam DeZure, Mary E Enama, Eric R James, Peter F Billingsley, Anusha Gunasekera, Anita Manoj, Minglin Li, Adam J Ruben, Tao Li, Abraham G Eappen, Richard E Stafford, Natasha Kc, Tooba Murshedkar, Floreliz H Mendoza, Ingelise J Gordon, Kathryn L Zephir, LaSonji A Holman, Sarah H Plummer, Cynthia S Hendel, Laura Novik, Pamela J M Costner, Jamie G Saunders, Nina M Berkowitz, Barbara J Flynn, Martha C Nason, Lindsay S Garver, Matthew B Laurens, Christopher V Plowe, Thomas L Richie, Barney S Graham, Mario Roederer, B Kim Lee Sim, Julie E Ledgerwood, Stephen L Hoffman, Robert A Seder
A live-attenuated malaria vaccine, Plasmodium falciparum sporozoite vaccine (PfSPZ Vaccine), confers sterile protection against controlled human malaria infection (CHMI) with Plasmodium falciparum (Pf) parasites homologous to the vaccine strain up to 14 mo after final vaccination. No injectable malaria vaccine has demonstrated long-term protection against CHMI using Pf parasites heterologous to the vaccine strain. Here, we conducted an open-label trial with PfSPZ Vaccine at a dose of 9.0 × 10(5) PfSPZ administered i...
February 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28222269/restoring-cftr-function-reduces-airway-bacteria-and-inflammation-in-people-with-cystic-fibrosis-and-chronic-lung-infections
#2
Katherine B Hisert, Sonya L Heltshe, Christopher Pope, Peter Jorth, Xia Wu, Rachael M Edwards, Matthew Radey, Frank J Accurso, Daniel J Wolter, Gordon Cooke, Ryan J Adam, Suzanne Carter, Brenda Grogan, Jan L Launspach, Seamas C Donnelly, Charles Gallagher, James E Bruce, David Stoltz, Michael J Welsh, Lucas R Hoffman, Edward F McKone, Pradeep K Singh
RATIONALE: Previous work indicates that ivacaftor improves CFTR activity and lung function in people with cystic fibrosis (CF) and G551D-CFTR mutations, but does not reduce density of bacteria or markers of inflammation in the airway. These findings raise the possibility that infection and inflammation may progress independently of CFTR activity once CF lung disease is established. OBJECTIVES: To better understand the relationship between CFTR activity, airway microbiology and inflammation, and lung function in subjects with CF and chronic airway infections...
February 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28221061/a-randomized-controlled-trial-of-a-smartphone-app-for-posttraumatic-stress-disorder-symptoms
#3
Eric Kuhn, Nitya Kanuri, Julia E Hoffman, Donn W Garvert, Josef I Ruzek, C Barr Taylor
OBJECTIVE: Posttraumatic stress disorder (PTSD) is highly prevalent in the population, but relatively few affected individuals receive treatment for it. Smartphone applications (apps) could help address this unmet need by offering sound psychoeducational information and evidence-based cognitive behavioral coping tools. We conducted a randomized controlled trial to assess the efficacy of a free, publicly available smartphone app (PTSD Coach) for self-management of PTSD symptoms. METHOD: One hundred 20 participants who were an average of 39 years old, mostly women (69...
March 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28218903/macrophage-migration-inhibitory-factor-downregulation-a-novel-mechanism-of-resistance-to-anti-angiogenic-therapy
#4
B A Castro, P Flanigan, A Jahangiri, D Hoffman, W Chen, R Kuang, M De Lay, G Yagnik, J R Wagner, S Mascharak, M Sidorov, S Shrivastav, G Kohanbash, H Okada, M K Aghi
Anti-angiogenic therapies for cancer such as VEGF neutralizing antibody bevacizumab have limited durability. While mechanisms of resistance remain undefined, it is likely that acquired resistance to anti-angiogenic therapy will involve alterations of the tumor microenvironment. We confirmed increased tumor-associated macrophages in bevacizumab-resistant glioblastoma patient specimens and two novel glioblastoma xenograft models of bevacizumab resistance. Microarray analysis suggested downregulated macrophage migration inhibitory factor (MIF) to be the most pertinent mediator of increased macrophages...
February 20, 2017: Oncogene
https://www.readbyqxmd.com/read/28217745/the-baltic-sea-virome-diversity-and-transcriptional-activity-of-dna-and-rna-viruses
#5
Lisa Zeigler Allen, John P McCrow, Karolina Ininbergs, Christopher L Dupont, Jonathan H Badger, Jeffery M Hoffman, Martin Ekman, Andrew E Allen, Birgitta Bergman, J Craig Venter
Metagenomic and metatranscriptomic data were generated from size-fractionated samples from 11 sites within the Baltic Sea and adjacent marine waters of Kattegat and freshwater Lake Torneträsk in order to investigate the diversity, distribution, and transcriptional activity of virioplankton. Such a transect, spanning a salinity gradient from freshwater to the open sea, facilitated a broad genome-enabled investigation of natural as well as impacted aspects of Baltic Sea viral communities. Taxonomic signatures representative of phages within the widely distributed order Caudovirales were identified with enrichments in lesser-known families such as Podoviridae and Siphoviridae...
January 2017: MSystems
https://www.readbyqxmd.com/read/28216244/safety-and-efficacy-of-pfspz-vaccine-against-plasmodium-falciparum-via-direct-venous-inoculation-in-healthy-malaria-exposed-adults-in-mali-a-randomised-double-blind-phase-1-trial
#6
Mahamadou S Sissoko, Sara A Healy, Abdoulaye Katile, Freda Omaswa, Irfan Zaidi, Erin E Gabriel, Bourama Kamate, Yacouba Samake, Merepen A Guindo, Amagana Dolo, Amadou Niangaly, Karamoko Niaré, Amatigue Zeguime, Kourane Sissoko, Hama Diallo, Ismaila Thera, Kelly Ding, Michael P Fay, Elise M O'Connell, Thomas B Nutman, Sharon Wong-Madden, Tooba Murshedkar, Adam J Ruben, Minglin Li, Yonas Abebe, Anita Manoj, Anusha Gunasekera, Sumana Chakravarty, B Kim Lee Sim, Peter F Billingsley, Eric R James, Michael Walther, Thomas L Richie, Stephen L Hoffman, Ogobara Doumbo, Patrick E Duffy
BACKGROUND: Plasmodium falciparum sporozite (PfSPZ) Vaccine is a metabolically active, non-replicating, whole malaria sporozoite vaccine that has been reported to be safe and protective against P falciparum controlled human malaria infection in malaria-naive individuals. We aimed to assess the safety and protective efficacy of PfSPZ Vaccine against naturally acquired P falciparum in malaria-experienced adults in Mali. METHODS: After an open-label dose-escalation study in a pilot safety cohort, we did a double-blind, randomised, placebo-controlled trial based in Donéguébougou and surrounding villages in Mali...
February 16, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28215422/coronary-artery-bypass-graft-surgery-using%C3%A2-the-radial-artery-right-internal-thoracic-artery-or-saphenous-vein-as-the%C3%A2-second%C3%A2-conduit
#7
Robert F Tranbaugh, Thomas A Schwann, Daniel G Swistel, Kamellia R Dimitrova, Laila Al-Shaar, Darryl M Hoffman, Charles M Geller, Milo Engoren, Sandhya K Balaram, John D Puskas, Robert H Habib
BACKGROUND: It is not clear whether radial artery (RA), right internal thoracic artery (RITA), or saphenous vein (SV) is the preferred second bypass graft during coronary artery bypass graft surgery using the left internal thoracic artery (LITA) in patients aged less or greater than 70 years. METHODS: Late survival data were collected for 13,324 consecutive, isolated, primary coronary artery bypass graft surgery patients from three hospitals. Cox regression analysis was performed on all patients grouped by age...
February 16, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28215197/growth-responses-of-entire-and-immunocastrated-male-pigs-to-dietary-protein-with-and-without-ractopamine-hydrochloride
#8
T Needham, L C Hoffman, R M Gous
The interaction between dietary balanced protein, ractopamine (RAC) and Improvac (IMP) on the growth response of 120 individually penned male PIC© pigs was evaluated. The pigs entered the trial at 16 weeks of age and were assigned to 12 treatments using a 2×2×3 factorial design. Three balanced protein diets, formulated with standard illeal digestible lysine levels of 7.50 (low), 9.79 (medium) and 12.07 g/kg (high), were fed from 20 weeks. Improvac was administered at 16 and 20 weeks, the booster being given 4 weeks before slaughter...
February 20, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28211105/joint-reconstruction-of-ictal-inter-ictal-spect-data-for-improved-epileptic-foci-localization
#9
Yothin Rakvongthai, Frederic Fahey, Korn Borvorntanajanya, Supatporn Tepmongkol, Usanee Vutrapongwatana, Katherine Zukotynski, Georges El Fakhri, Jinsong Ouyang
PURPOSE: To improve the performance for localizing epileptic foci, we have developed a joint ictal/inter-ictal SPECT reconstruction method in which ictal and inter-ictal SPECT projections are simultaneously reconstructed to obtain the differential image. METHODS: We have developed a SPECT reconstruction method that jointly reconstructs ictal and inter-ictal SPECT projection data. We performed both phantom and patient studies to evaluate the performance of our joint method for epileptic foci localization as compared with the conventional subtraction method in which the differential image is obtained by subtracting the inter-ictal image from the co-registered ictal image...
February 16, 2017: Medical Physics
https://www.readbyqxmd.com/read/28210390/a-case-of-lichen-planus-pigmentosus-with-facial-dyspigmentation-responsive-to-combination-therapy-with-chemical-peels-and-topical-retinoids
#10
Marisa Wolff, Nina Sabzevari, Charles Gropper, Cindy Hoffman
Lichen planus pigmentosus is a photodistributed dyschromia of unknown etiology described clinically as hyperpigmented gray-blue or brown-black macules or patches in a photodistributed pattern. Although there has been some debate, lichen planus pigmentosus is considered by many to be a separate diagnostic entity from ashy dermatosis or erythema dyschromicum perstans, which shares similar characteristics. Various treatment strategies have been applied to help resolve or improve the appearance of lichen planus pigmentosus lesions; however, an optimal treatment method is yet to be elucidated...
November 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28208776/beidou-signal-acquisition-with-neumann-hoffman-code-modulation-in-a-degraded-channel
#11
Lin Zhao, Aimeng Liu, Jicheng Ding, Jing Wang
With the modernization of global navigation satellite systems (GNSS), secondary codes, also known as the Neumann-Hoffman (NH) codes, are modulated on the satellite signal to obtain a better positioning performance. However, this leads to an attenuation of the acquisition sensitivity of classic integration algorithms because of the frequent bit transitions that refer to the NH codes. Taking weak BeiDou navigation satellite system (BDS) signals as objects, the present study analyzes the side effect of NH codes on acquisition in detail and derives a straightforward formula, which indicates that bit transitions decrease the frequency accuracy...
February 9, 2017: Sensors
https://www.readbyqxmd.com/read/28207658/association-between-paraspinal-muscle-morphology-clinical-symptoms-and-functional-status-in-patients-with-degenerative-cervical-myelopathy
#12
Maryse Fortin, Octavian Dobrescu, Matthew Courtemanche, Carolyn J Sparrey, Carlo Santaguida, Michael G Fehlings, Michael H Weber
STUDY DESIGN: A cross-sectional study. OBJECTIVE: The aim of this study was to assess fatty infiltration and asymmetry of the multifidus (MF), semispinalis cervicis (SCer), semispinalis capitis (SCap), and splenius capitis (SPL) muscles in patients with degenerative cervical myelopathy (DCM), and evaluate their correlations with clinical symptoms and functional scores. SUMMARY OF BACKGROUND DATA: Cervical muscle alterations have been reported in patients with chronic neck pain, but the assessment of cervical muscle morphology has been overlooked in patients with DCM...
February 15, 2017: Spine
https://www.readbyqxmd.com/read/28207279/angiotensin-converting-inhibitors-and-angiotensin-ii-receptor-blockers-and-longitudinal-change-in-percent-emphysema-on-computed-tomography-the-mesa-lung-study
#13
Megha A Parikh, Carrie P Aaron, Eric A Hoffman, Joseph E Schwartz, Jaime Madrigano, John H M Austin, Ravi Kalhan, Gina Lovasi, Karol Watson, Karen Hinckley Stukovsky, R Graham Barr
RATIONALE: Chronic obstructive pulmonary disease (COPD) is the third-leading cause of death in the United States. Emphysema on computed tomography (CT) is associated with increased morbidity and mortality in patients with and without spirometrically defined COPD but no available medications target emphysema.  Transforming growth factor beta (TGF-β) and endothelial dysfunction are implicated in emphysema pathogenesis, and angiotensin II receptor blockers (ARB) inhibit TGF-β, improve endothelial function and restore airspace architecture in murine models...
February 16, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28205648/identification-of-a-novel-nampt-inhibitor-by-crispr-cas9-chemogenomic-profiling-in-mammalian-cells
#14
David Estoppey, Jeffrey W Hewett, Chantale T Guy, Edmund Harrington, Jason R Thomas, Markus Schirle, Rachel Cuttat, Annick Waldt, Bertran Gerrits, Zinger Yang, Sven Schuierer, Xuewen Pan, Kevin Xie, Walter Carbone, Judith Knehr, Alicia Lindeman, Carsten Russ, Elizabeth Frias, Gregory R Hoffman, Malini Varadarajan, Nadire Ramadan, John S Reece-Hoyes, Qiong Wang, Xin Chen, Gregory McAllister, Guglielmo Roma, Tewis Bouwmeester, Dominic Hoepfner
Chemogenomic profiling is a powerful and unbiased approach to elucidate pharmacological targets and the mechanism of bioactive compounds. Until recently, genome-wide, high-resolution experiments of this nature have been limited to fungal systems due to lack of mammalian genome-wide deletion collections. With the example of a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor, we demonstrate that the CRISPR/Cas9 system enables the generation of transient homo- and heterozygous deletion libraries and allows for the identification of efficacy targets and pathways mediating hypersensitivity and resistance relevant to the compound mechanism of action...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28205255/effect-of-postnatal-hiv-treatment-on-clinical-mastitis-and-breast-inflammation-in-hiv-infected-breast-feeding-women
#15
Sabrina Zadrozny, Daniel Westreich, Michael G Hudgens, Charles Chasela, Denise J Jamieson, Francis Martinson, Chifundo Zimba, Gerald Tegha, Irving Hoffman, William C Miller, Brian W Pence, Caroline C King, Athena P Kourtis, Wezi Msungama, Charles van der Horst
BACKGROUND: The relationship between mastitis and antiretroviral therapy among HIV-positive, breast-feeding women is unclear. METHODS: In the Breastfeeding, Antiretrovirals, and Nutrition (BAN) study, conducted in Lilongwe, Malawi, 2369 mother-infant pairs were randomized to a nutritional supplement group and to one of three treatment groups: maternal antiretroviral therapy (ART), infant nevirapine (NVP) or standard of care for 24 weeks of exclusive breast-feeding and 4 weeks of weaning...
February 16, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28205202/polish-forum-for-prevention-guidelines-on-dyslipidaemia-update-2016
#16
Barbara Cybulska, Wiktor B Szostak, Krzysztof J Filipiak, Grzegorz Kopeć, Wojciech Drygas, Longina Kłosiewicz-Latoszek, Klaudia Knap, Andrzej Pająk, Jakub Podolec, Tomasz Zdrojewski, Danuta Czarnecka, Piotr Jankowski, Maciej Małecki, Grażyna Nowicka, Jerzy Stańczyk, Agnieszka Sarnecka, Anna Członkowska, Maciej Niewada, Anetta Undas, Adam Windak, Piotr Hoffman, Piotr Podolec
No abstract text is available yet for this article.
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28203494/flap-reconstruction-for-pressure-ulcers-an-outcomes-analysis
#17
Ravinder Bamba, James J Madden, Ashley N Hoffman, Justine S Kim, Wesley P Thayer, Lillian B Nanney, Marcia E Spear
BACKGROUND: Historically, complication rates after pressure ulcer reconstruction utilizing flap coverage have been high. Patients undergoing operations for pressure ulcer coverage typically have multiple risk factors for postoperative complications. The purpose of this study was to examine a large patient series in the pressure ulcer population to uncover objective evidence of the linkage between risk factors and outcomes after flap coverage. METHODS: This study was a retrospective chart review of patients who underwent flap reconstruction for a pressure ulcer between 1997 and 2015...
January 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28202580/spinal-disinhibition-in-experimental-and-clinical-painful-diabetic-neuropathy
#18
Andrew G Marshall, Corinne Lee-Kubli, Shazli Azmi, Michael Zhang, Maryam Ferdousi, Teresa Mixcoatl-Zecuatl, Ioannis N Petropoulos, Georgios Ponirakis, Mark S Fineman, Hassan Fadavi, Katie Frizzi, Mitra Tavakoli, Maria Jeziorska, Corinne G Jolivalt, Andrew J M Boulton, Nathan Efron, Nigel A Calcutt, Rayaz A Malik
Impaired rate dependent depression (RDD) of the Hoffman-reflex is associated with reduced dorsal spinal cord potassium chloride co-transporter expression and impaired spinal GABAA receptor function, indicative of spinal inhibitory dysfunction. We have investigated the pathogenesis of impaired RDD in diabetic rodents exhibiting features of painful neuropathy and the translational potential of this marker of spinal inhibitory dysfunction in human painful diabetic neuropathy. Impaired RDD and allodynia were present in type 1 and type 2 diabetic rats but not in rats with type 1 diabetes receiving insulin supplementation that did not restore normoglycemia...
February 15, 2017: Diabetes
https://www.readbyqxmd.com/read/28201739/geographic-disparities-in-cytomegalovirus-infection-during-pregnancy
#19
Paul M Lantos, Kate Hoffman, Sallie R Permar, Pearce Jackson, Brenna L Hughes, Geeta K Swamy
No abstract text is available yet for this article.
February 14, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28199482/pneumococcal-pneumonia-requiring-hospitalization-in-u-s-children-in-the-13-valent-pneumococcal-conjugate-vaccine-era
#20
Liset Olarte, William J Barson, Ryan M Barson, José R Romero, John S Bradley, Tina Q Tan, Laurence B Givner, Jill A Hoffman, Philana Ling Lin, Kristina G Hultén, Edward O Mason, Sheldon L Kaplan
No abstract text is available yet for this article.
February 11, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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