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https://www.readbyqxmd.com/read/28922778/circulating-folate-vitamin-b6-and-methionine-in-relation-to-lung-cancer-risk-in-the-lung-cancer-cohort-consortium-lc3
#1
Anouar Fanidi, David C Muller, Jian-Min Yuan, Victoria L Stevens, Stephanie J Weinstein, Demetrius Albanes, Ross Prentice, Cynthia A Thomsen, Mary Pettinger, Qiuyin Cai, William J Blot, Jie Wu, Alan A Arslan, Anne Zeleniuch-Jacquotte, Marjorie L McCullough, Loic Le Marchand, Lynne R Wilkens, Christopher A Haiman, Xuehong Zhang, Jiali Han, Meir J Stampfer, Stephanie A Smith-Warner, Edward Giovannucci, Graham G Giles, Allison M Hodge, Gianluca Severi, Mikael Johansson, Kjell Grankvist, Arnulf Langhammer, Steinar Krokstad, Marit Næss, Renwei Wang, Yu-Tang Gao, Lesley M Butler, Woon-Puay Koh, Xiao-Ou Shu, Yong-Bing Xiang, Honglan Li, Wei Zheng, Qing Lan, Kala Visvanathan, Judith Hoffman Bolton, Per Magne Ueland, Øivind Midttun, Arve Ulvik, Neil E Caporaso, Mark Purdue, Regina G Ziegler, Neal D Freedman, Julie E Buring, I-Min Lee, Howard D Sesso, J Michael Gaziano, Jonas Manjer, Ulrika Ericson, Caroline Relton, Paul Brennan, Mattias Johansson
Background: Circulating concentrations of B vitamins and factors related to one-carbon metabolism have been found to be strongly inversely associated with lung cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The extent to which these associations are present in other study populations is unknown. Methods: Within 20 prospective cohorts from the National Cancer Institute Cohort Consortium, a nested case-control study was designed including 5364 incident lung cancer case patients and 5364 control subjects who were individually matched to case patients by age, sex, cohort, and smoking status...
January 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28922211/acute-effects-of-ammonia-inhalants-on-strength-and-power-performance-in-trained-men
#2
Sandro Bartolomei, Federico Nigro, Gubellini Luca, Semprini Gabriele, Simone Ciacci, Jay R Hoffman, Franco Merni
The aim of the present study was to investigate the influence of ammonia inhalants on lower body power and maximal isometric strength in trained men. Twenty experienced resistance trained men (age = 26.7 ± 3.7 y; body weight = 80.59 ± 9.0 kg; body height = 179.5 ± 5.7 cm) were tested for counter movement jump power (CMJP), maximal force and rate of force development (pRFD20) expressed during an isometric mid-thigh pull (IMTP). Assessments were performed using either an ammonia salt inhalants (AI), a placebo (PL) or no inhalants (N)...
September 12, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28916185/alveolar-eosinophilia-in-current-smokers-with-chronic-obstructive-pulmonary-disease-in-the-spiromics-cohort
#3
Carlos H Martinez, Sara X Li, Andrew J Hirzel, Valerie R Stolberg, Neil E Alexis, R Graham Barr, Eugene R Bleecker, Elizabeth E Carretta, Stephanie A Christenson, Christopher B Cooper, David J Couper, Claire M Doerschuk, MeiLan K Han, Nadia N Hansel, Annette T Hastie, Eric A Hoffman, Robert J Kaner, Fernando J Martinez, Deborah A Meyers, Wanda K O'Neal, Robert Paine, Nirupama Putcha, Stephen I Rennard, Prescott G Woodruff, Michelle Zeidler, Jeffrey L Curtis, Christine M Freeman
Active smoking in stable COPD subjects significantly increased eosinophil accumulation in the distal airspaces, but not in sputum or peripheral blood. Our findings support the need to investigate this cell-type as a potential driver of COPD symptomatology and progression.
September 12, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28915287/efficacy-and-safety-of-desoximetasone-0-25-spray-in-adult-atopic-dermatitis-subjects-pilot-study
#4
Lauren K Hoffman, Leon Kircik
BACKGROUND: Atopic dermatitis (AD) is a chronic, relapsing, inflammatory skin disorder. One of the most disturbing symptoms of AD is pruritus. The first line treatment for AD is topical corticosteroids, topical immunomodulators, topical barrier creams, oral antihistamines, and systemic treatments. Desoximetasone 0.25% spray is a superpotent topical corticosteroid delivered in a novel way and it may be a suitable option for the treatment of pruritus in adult atopic dermatitis patients...
September 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28914911/iridescence-free-and-narrowband-perfect-light-absorption-in-critically-coupled-metal-high-index-dielectric-cavities
#5
M ElKabbash, E Ilker, T Letsou, N Hoffman, A Yaney, M Hinczewski, G Strangi
Perfect light absorption in the visible and near-infrared (NIR) was demonstrated using metamaterials, plasmonic nanostructures, and thin films. Thin film absorbers offer a simple and low-cost design as they can be produced on large areas and without lithography. Light is strongly absorbed in thin film metal-dielectric-metal (MDM) cavities at their resonance frequencies. However, a major drawback of MDM absorbers is their strong resonance iridescence, i.e., angle dependence. Here, we solve the iridescence problem by achieving angle-insensitive narrowband perfect and near-perfect light absorption...
September 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28912894/genetically-encoded-photoactuators-and-photosensors-for-characterization-and-manipulation-of-pluripotent-stem-cells
#6
REVIEW
Jordan E Pomeroy, Hung X Nguyen, Brenton D Hoffman, Nenad Bursac
Our knowledge of pluripotent stem cell biology has advanced considerably in the past four decades, but it has yet to deliver on the great promise of regenerative medicine. The slow progress can be mainly attributed to our incomplete understanding of the complex biologic processes regulating the dynamic developmental pathways from pluripotency to fully-differentiated states of functional somatic cells. Much of the difficulty arises from our lack of specific tools to query, or manipulate, the molecular scale circuitry on both single-cell and organismal levels...
2017: Theranostics
https://www.readbyqxmd.com/read/28912051/the-relationship-between-coronary-artery-disease-risk-factors-and-carotid-intima-media-thickness-in-children
#7
Dan White, Rebecca Place, Timothy Michael, Eric Hoffman, Paul M Gordon, Paul Visich
OBJECTIVE: To determine the number of coronary artery disease risk factors and the individual coronary artery disease risk factors that have a negative influence on carotid intima-media thickness in children. STUDY DESIGN: One hundred and nineteen children (mean age 10.51 ± 0.52 years; 51% female) participated. Each subject was assessed for carotid intima-media thickness, total cholesterol, high-density lipoprotein cholesterol (HDL-C), glucose, body mass index (BMI), and resting blood pressure...
September 11, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28910200/comparison-of-two-%C3%AE-alanine-dosing-protocols-on-muscle-carnosine-elevations
#8
David D Church, Jay R Hoffman, Alyssa N Varanoske, Ran Wang, Kayla M Baker, Michael B La Monica, Kyle S Beyer, Sarah J Dodd, Leonardo P Oliveira, Roger C Harris, David H Fukuda, Jeffrey R Stout
OBJECTIVE: β-alanine (BA) is a nonproteogenic amino acid that combines with histidine to form carnosine. The amount taken orally in individual doses, however, is limited due to symptoms of paresthesia that are associated with higher doses. The use of a sustained-release formulation has been reported to reduce the symptoms of paresthesia, suggesting that a greater daily dose may be possible. The purpose of the present study was to determine whether increasing the daily dose of BA can result in a similar increase in muscle carnosine in a reduced time...
September 14, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28905991/target-of-rapamycin-signaling-orchestrates-growth-defense-trade-offs-in-plants
#9
David De Vleesschauwer, Osvaldo Filipe, Gena Hoffman, Hamed Soren Seifi, Ashley Haeck, Patrick Canlas, Jonas Van Bockhaven, Evelien De Waele, Kristof Demeestere, Pamela Ronald, Monica Hofte
Plant defense to microbial pathogens is often accompanied by significant growth inhibition. How plants merge immune system function with normal growth and development is still poorly understood. Here, we investigated the role of target of rapamycin (TOR), an evolutionary conserved serine/threonine kinase, in the plant defense response. We used rice as a model system and applied a combination of chemical, genetic, genomic and cell-based analyses. We demonstrate that ectopic expression of TOR and Raptor (regulatory-associated protein of mTOR), a protein previously demonstrated to interact with TOR in Arabidopsis, positively regulates growth and development in rice...
September 14, 2017: New Phytologist
https://www.readbyqxmd.com/read/28905351/the-tissue-factor-pathway-and-wound-healing
#10
Maureane Hoffman
No abstract text is available yet for this article.
September 13, 2017: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/28903915/obesity-modulates-diaphragm-curvature-in-subjects-with-and-without-copd
#11
Aladin M Boriek, Michael A Lopez, Cristina Velasco, Azam A Bakir, Anna Frolov, Shari Wynd, Tony G Babb, Nicola A Hanania, Eric A Hoffman, Amir Sharafkhaneh
BACKGROUND: Obesity is a common co-morbidity of COPD and has been associated with worse outcomes. However, it is unknown whether the interaction between obesity and COPD modulates diaphragm shape and consequently its function. The body mass index has been used as a correlate of obesity. We tested the hypothesis that the shape of the diaphragm muscle and size of the ring of its insertion in Non-COPD and COPD subjects are modulated by BMI. METHODS: We recruited 48 COPD patients with post-bronchiodilator FEV1/FVC < 0...
September 13, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28903369/toxicology-and-efficacy-of-tumor-targeting-salmonella-typhimurium-a1-r-compared-to-vnp-20009-in-a-syngeneic-mouse-tumor-model-in-immunocompetent-mice
#12
Yong Zhang, Wenluo Cao, Makoto Toneri, Nan Zhang, Tasuku Kiyuna, Takashi Murakami, Scott D Nelson, Sarah M Dry, Yunfeng Li, Shukuan Li, Xiaoen Wang, Huaiyu Ma, Arun S Singh, Fritz C Eilber, Robert M Hoffman, Ming Zhao
Salmonella typhimurium A1-R (S. typhimurium A1-R) attenuated by leu and arg auxotrophy has been shown to target multiple types of cancer in mouse models. In the present study, toxicologic and biodistribution studies of tumor-targeting S. typhimurium A1-R and S. typhimurium VNP20009 (VNP 20009) were performed in a syngeneic tumor model growing in immunocompetent BALB/c mice. Single or multiple doses of S. typhimurium A1-R of 2.5 × 10(5) and 5 × 10(5) were tolerated. A single dose of 1 × 10(6) resulted in mouse death...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28902427/nlrp3-inflammasome-driven-liver-injury-and-fibrosis-roles-of-il-17-and-tnf
#13
Alexander Wree, Matthew D McGeough, Maria Eugenia Inzaugarat, Akiko Eguchi, Susanne Schuster, Casey D Johnson, Carla A Peña, Lukas J Geisler, Bettina G Papouchado, Hal M Hoffman, Ariel E Feldstein
The NLRP3 inflammasome, a caspase-1 activation platform plays a key role in the modulation of liver inflammation and fibrosis. Here, we tested the hypothesis that interleukin 17 (IL-17) and tumor necrosis factor (TNF) are key cytokines involved in amplifying and perpetuating the liver damage and fibrosis resulting from NLRP3 activation. To address this hypothesis gain of function Nlrp3(A350V) knock-in mice were bred onto il17a and Tnf knockout backgrounds allowing for constitutive Nlrp3 activation in myeloid derived cells in mice deficient in IL-17 or TNF...
September 13, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28899138/un-homme-manqu%C3%A3-freud-s-engagement-with-alfred-adler-s-masculine-protest-commentary-on-balsam
#14
Leon Hoffman
No abstract text is available yet for this article.
February 2017: Journal of the American Psychoanalytic Association
https://www.readbyqxmd.com/read/28899018/encephalitis-lethargica-100-years-after-the-epidemic
#15
Leslie A Hoffman, Joel A Vilensky
No abstract text is available yet for this article.
August 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28898476/proceeding-report-of-the-symposium-on-hidradenitis-suppurativa-advances-shsa
#16
Ali Mehdizadeh, Afsaneh Alavi, Raed Alhusayen, Boris Bauer, Falk G Bechara, Marc Bourcier, Alain Brassard, Vahid Djamei, Jan Dutz, Ralph George, Mondana Ghias, Melinda Gooderham, Iltefat Hamzavi, Lauren K Hoffman, Angela Hou, Howard Hu, Alexa Boer Kimball, Mark Kirchhof, Darya Kryzskaya, Maria Del Carmen Liy Wong, Michelle A Lowes, Charles W Lynde, Chelsea McLellen, Errol Prens, Lisette Prens, Tetyana Rogalska, R Gary Sibbald, Mia Sisic, Marcus G Tan, Dennis D Wong
The Symposium on Hidradenitis Suppurativa Advances (SHSA) took place on 22-23 October 2016 at Women's College Hospital in Toronto, Canada. This symposium was a joint meeting of the Canadian Hidradenitis Suppurativa Foundation (CHSF), and the Hidradenitis Suppurativa Foundation (HSF Inc.) founded in USA. The purpose of this meeting was to gather well-known researchers from different disciplines to discuss most recent innovations, practical challenges and potential solutions to issues related to management and care of HS patients...
September 12, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28895996/transcatheter-aortic-valve-implantation-expert-consensus-of-the-association-of-cardiovascular-interventions-of-the-polish-cardiac-society-and-the-polish-society-of-cardio-thoracic-surgeons-approved-by-the-board-of-the-polish-cardiac-society%C3%A2
#17
Radosław Parma, Michał O Zembala, Maciej Dąbrowski, Dariusz Jagielak, Adam Witkowski, Piotr Suwalski, Dariusz Dudek, Piotr Olszówka, Wojciech Wojakowski, Roman Przybylski, Robert Gil, Mariusz Kuśmierczyk, Maciej Lesiak, Jerzy Sadowski, Sławomir Dobrzycki, Andrzej Ochała, Piotr Hoffman, Bogusław Kapelak, Jarosław Kaźmierczak, Marek Jasiński, Janina Stępińska, Piotr Szymański, Tomasz Hryniewiecki, Janusz Kochman, Marek Grygier, Marian Zembala, Jacek Legutko, Jacek Różański
Patients with severe symptomatic aortic stenosis have a poor prognosis with medical management alone, and surgical aortic valve replacement can improve symptoms and survival. In recent years, transcatheter aortic valve implantation (TAVI) has been demonstrated to improve survival in inoperable patients and to be an alternative treatment in patients in whom the risk of surgical morbidity or mortality is high or intermediate. A representative expert committee, summoned by the Association of Cardiovascular Interventions of the Polish Cardiac Society (ACVI) and the Polish Society of Cardio-Thoracic Surgeons, devel-oped this Consensus Statement in transcatheter aortic valve implantation...
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28895432/intraductal-laser-fiber-tip-fracture-and-retrieval-during-sialendoscopic-laser-assisted-lithotripsy
#18
Andrew J Goates, Raymond W Kung, Chad R Tracy, Henry T Hoffman
Fragmentation of flexible laser fiber tips has been reported to occur during therapeutic bronchoscopy and urologic stone treatment. We report fragmentation of 200-µm single-use silica-based fibers during sialendoscopy-controlled Holmium:YAG laser treatment of a parotid and a submandibular stone. The technique employed to successfully retrieve the fiber tips is described in the context of identifying this potential complication from endoscopic management of sialolithiasis.
September 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28895063/considerations-in-the-use-of-body-mass-change-to-estimate-change-in-hydration-status-during-a-161-kilometer-ultramarathon-running-competition
#19
Martin D Hoffman, Eric D B Goulet, Ronald J Maughan
Hydration guidelines found in the scientific and popular literature typically advise that body mass losses beyond 2% should be avoided during exercise. In this work, we demonstrate that these guidelines are not applicable to prolonged exercise of several hours where body mass loss does not reflect an equivalent loss of body water due to the effects of body mass change from substrate use, release of water bound with muscle and liver glycogen, and production of water during substrate metabolism. These effects on the body mass loss required to maintain body water balance are shown for a 161-km mountain ultramarathon running competition participant utilizing published data for the total energy cost, exogenous energy consumption and percentage from each fuel source, average participant body mass, and the extent of soft tissue fluid accumulation during an ultramarathon...
September 11, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28894819/computational-modelling-of-cough-function-and-airway-penetrant-behavior-in-patients-with-disorders-of-laryngeal-function
#20
Bari Hoffman Ruddy, Don Nadun Kuruppumullage, Giselle Carnaby, Michael Crary, Jeffery Lehman, Olusegun J Ilegbusi
OBJECTIVE/HYPOTHESIS: Patients with laryngeal disorders often exhibit changes to cough function contributing to aspiration episodes. Two primary cough variables (peak cough flow: PCF and compression phase duration: CPD) were examined within a biomechanical model to determine their impact on characteristics that impact airway compromise. STUDY DESIGN: Computational study. METHODS: A Computational Fluid Dynamics (CFD) technique was used to simulate fluid flow within an upper airway model reconstructed from patient CT images...
February 2017: Laryngoscope Investigative Otolaryngology
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