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https://www.readbyqxmd.com/read/29213511/lewy-and-his-inclusion-bodies-discovery-and-rejection
#1
Eliasz Engelhardt, Marleide da Mota Gomes
Fritz Jacob Heinrich Lewy described the pathology of Paralysis agitans [Parkinson disease] and was the first to identify eosinophilic inclusion bodies in neurons of certain brain nuclei, later known as Lewy bodies, the pathological signature of the Lewy body diseases. In 1912, he published his seminal study, followed soon after by an update paper, and 10 years later, in 1923, by his voluminous book, where he exhaustively described the subject. The publication provided extensive information on the pathology of Paralysis agitans, and the entirely novel finding of eosinophilic inclusion bodies, which would become widely recognized and debated in the future...
April 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29140146/awareness-and-attitude-towards-use-of-dietary-supplements-and-the-perceived-outcomes-among-saudi-adult-male-members-of-fitness-centers-in-saudi-arabia
#2
Hanan A Alfawaz, Soundararajan Krishnaswamy, Latifah Al-Faifi, Halima Ali Bin Atta, Mohammad Al-Shayaa, Saad A Alghanim, Nasser M Al-Daghri
Dietary supplements are believed to enhance athletic performance and/or prevent/reverse pathological states. Despite the increasing use of dietary supplements in Saudi Arabia, systematic studies in this field are lacking. This study aims to assess the relation between demographic and social characteristics and dietary supplement use among adult males in Saudi Arabia. Demographic and dietary supplements data from fitness club participants were collected through a questionnaire and Pearson Chi-square test was used to determine associations...
November 15, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29056123/immunohistochemical-expression-of-cd10-bcl6-and-mum1-in-differentiating-diffuse-large-b-cell-lymphoma-subtypes
#3
Akhter Ali Bajwa, Muhammad Tahir Khadim, Hafeez Ud Din, Syed Salman Ali, Unaiza Jamil, Umair Aslam Shahzad Khan
OBJECTIVE: To determine the immunohistochemical expression of CD10, BCL6 and MUM1 in differentiating diffuse large B cell lymphoma subtypes. STUDY DESIGN: Descriptive, cross-sectional study. PLACE AND DURATION OF STUDY: Department of Histopathology, Armed Forces Institute of Pathology, Rawalpindi, from November 2014 to May 2015. METHODOLOGY: Newly diagnosed cases of DLBCLon H&E stain as well as IHC markers, according to WHO blue book 2008, were included in the study...
October 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28991760/centenary-of-the-birth-of-academician-prof-dr-isak-tadzer-founder-of-the-pathophysiology-and-nuclear-medicine-in-macedonia
#4
Borislav Karanfilski
Academician Prof. Dr. Isak Tadzer was born a hundred years ago on December 24, 1916 in Sofia. He completed the primary and secondary education at the German College in Sofia. In 1935 he began his studies at the Medical Faculty in Vienna, which he had to stop because of the annexation of Austria to Germany in 1938. He returned to Bulgaria where he continued his studies and graduated from the Medical Faculty in Sofia in 1941. During the War, 1941-1944, he was forcedly mobilized and he worked as a doctor in several villages...
September 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/28955419/cervical-cancer-in-southern-malawi-a-prospective-analysis-of-presentation-management-and-outcomes
#5
Pandora Rudd, Dermot Gorman, Samuel Meja, Petani Mtonga, Yankho Jere, Irene Chidothe, Ausbert T Msusa, M Jane Bates, Ewan Brown, Leo Masamba
BACKGROUND: Malawi has the highest age standardised rate of cervical cancer in the world. This study describes the presentation, management and short-term outcomes of patients with newly diagnosed cervical cancer at Queen Elizabeth Central Hospital (QECH), in Southern Malawi. METHODS: All patients with a new diagnosis of cervical cancer presenting to QECH between 1st January-1st July 2015 had demographic data, referral pathway, stage, histology and management prospectively recorded at presentation, and at two months after initial presentation...
June 2017: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/28876686/management-of-failed-mitral-valve-replacement-the-durban-experience
#6
D Kistan, M Booysen, G Alexander, T E Madiba
BACKGROUND: Mitral valve replacement is the procedure of choice in patients with severe mitral valve disease. However, these patients are surviving longer and are thus at an increased risk of prosthesis failure or valve-related complications. METHOD: Study setting: Inkosi Albert Luthuli Central Hospital, a tertiary referral Hospital in Durban. Study population: All patients undergoing redo mechanical mitral valve replacement surgery between January 2005 and December 2014...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28871375/walter-e-dandy-his-contributions-to-pituitary-surgery-in-the-context-of-the-overall-johns-hopkins-hospital-experience
#7
Andrea Corsello, Giulia Di Dalmazi, Fabiana Pani, Paulina Chalan, Roberto Salvatori, Patrizio Caturegli
BACKGROUND: Walter E. Dandy (1886-1946) was an outstanding neurosurgeon who spent his entire career at the Johns Hopkins Hospital. After graduating from medical school in 1910, he completed a research fellowship in the Hunterian laboratory with Harvey Cushing and then joined the Department of Surgery as resident, rising to the rank professor in 1931. Dandy made several contributions that helped building the neurosurgical specialty, most famously the introduction of pneumo-ventriculography to image brain lesions for which he received a Nobel prize nomination...
December 2017: Pituitary
https://www.readbyqxmd.com/read/28866346/surgical-management-of-deep-gluteal-syndrome-causing-sciatic-nerve-entrapment-a-systematic-review
#8
REVIEW
Jeffrey Kay, Darren de Sa, Laura Morrison, Emily Fejtek, Nicole Simunovic, Hal D Martin, Olufemi R Ayeni
PURPOSE: To assess the causes, surgical indications, patient-reported clinical outcomes, and complications in patients with deep gluteal syndrome causing sciatic nerve entrapment. METHODS: Three databases (PubMed, Ovid [MEDLINE], and Embase) were searched by 2 reviewers independently from database inception until September 7, 2016. The inclusion criteria were studies reporting on both arthroscopic and open surgery and those with Level I to IV evidence. Systematic reviews, conference abstracts, book chapters, and technical reports with no outcome data were excluded...
August 30, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28862111/how-can-we-improve-education-of-breast-surgeons-across-europe
#9
Agnieszka Kolacinska
The proposed global curriculum developed by the American Society of Surgical Oncology (SSO) and the European Society of Surgical Oncology (ESSO) and the textbook: provides a state-of- the- art of breast cancer surgery, complements the syllabus and curriculum of the Union Europeenne des Medecins Specialistes (UEMS) examination in breast surgery/ European Board of Surgery Qualification in Breast Surgery (EBSQinBS) administered by ESSO (1) Knowledge and understanding of the principles of breast cancer incidence, aetiology, risk factors, genetics, premalignant and high-risk lesions, pathology, prognostic and predictive factors, risk prediction models, screening, diagnosis and imaging, breast cancer, oncoplastic, reconstructive breast surgery, axillary surgery and future perspective for this, radiation therapy, neoadjuvant and adjuvant systemic treatment- endocrine-, immuno- and chemotherapy, side effects and toxicities of treatment, locoregional recurrence, follow-up, locally advanced breast cancer, metastatic breast cancer, breast cancer in young and elderly patients, survivor issues, lymphedema, palliative care, chroni pain, body image and sexuality, fertility issues, cognitive functions, etc...
July 2017: Chirurgia
https://www.readbyqxmd.com/read/28527023/-high-resolution-manometry-of-pharyngeal-swallowing-dynamics
#10
REVIEW
M Jungheim, M Ptok
BACKGROUND: To transport a bolus from the mouth into the stomach, regular contraction of the pharyngeal muscles and a coordinated function of the upper esophageal sphincter (UES) are necessary. The muscle contraction generates intraluminal pressure, which pushes the bolus continuously forward. In contrast to imaging studies, manometric methods enable assessment of intraluminal pressure buildup and the function of the muscles involved. These methods were initially established for the esophagus and have been used increasingly in the pharynx for 7-8 years...
May 19, 2017: HNO
https://www.readbyqxmd.com/read/28247228/update-from-the-4th-edition-of-the-world-health-organization-classification-of-head-and-neck-tumours-what-is-new-in-the-2017-who-blue-book-for-tumors-and-tumor-like-lesions-of-the-neck-and-lymph-nodes
#11
Nora Katabi, James S Lewis
The World Health Organization (WHO) 2017 Classification of Head and Neck Tumors ("Blue Book") will now include a new chapter on tumors and tumor-like lesions of the neck and lymph nodes, which was not included in the previous edition. Tumors and tumor-like lesions, including a variety of cysts and metastases, can arise in any component in the neck, including soft tissue, lymph nodes, and developmental remnants. The pathology and clinical features of metastatic carcinoma of unknown primary in the head and neck has changed dramatically in the last several years...
March 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/27941195/mucoceles-of-minor-salivary-glands-in-children-own-clinical-observations
#12
Bogumił Lewandowski, Robert Brodowski, Paweł Pakla, Aleksander Makara, Wojciech Stopyra, Bartek Startek
INTRODUCTION: Mucoceles are benign lesions associated with the pathology of the oral mucosa of minor salivary glands. Two types of cysts are distinguished depending on their pathogenesis. Most often they occur as a result of mechanical trauma and mucus extravasation into tissues or obstruction of the gland ducts. AIM: The aim of the study was to present our own experiences regarding mucoceles of minor salivary glands in the oral cavity taking into account how frequently the individual types of cysts occur in children...
2016: Developmental Period Medicine
https://www.readbyqxmd.com/read/27720561/histiocytic-proliferations
#13
REVIEW
Sarangarajan Ranganathan
The study of Histiocytic lesions has been a passion of Pepper Dehner over the years. He has contributed several case series and reviews on various categories of these diseases for over 4 decades, with his earliest articles in the 1970s. He has written on all aspects of the disease including seminal articles on Langerhans cell histiocytosis (LCH) and their prognostic features, his experiences with regressing atypical histiocytosis, his encounters with malignant histiocytosis, and classic articles on juvenile xanthogranuloma...
November 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27714682/glial-cells-and-integrity-of-the-nervous-system
#14
REVIEW
Rommy von Bernhardi, Jaime Eugenín-von Bernhardi, Betsi Flores, Jaime Eugenín León
Today, there is enormous progress in understanding the function of glial cells, including astroglia, oligodendroglia, Schwann cells, and microglia. Around 150 years ago, glia were viewed as a glue among neurons. During the course of the twentieth century, microglia were discovered and neuroscientists' views evolved toward considering glia only as auxiliary cells of neurons. However, over the last two to three decades, glial cells' importance has been reconsidered because of the evidence on their involvement in defining central nervous system architecture, brain metabolism, the survival of neurons, development and modulation of synaptic transmission, propagation of nerve impulses, and many other physiological functions...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27593846/retrospective-analysis-of-449-intracranial-meningioma-patients-operated-between-years-2007-2013-in-a-single-institute
#15
Emrah Celtikci, A Memduh Kaymaz, Gulsah Akgul, Burak Karaaslan, O Hakan Emmez, Alp Borcek
AIM: Meningioma literature has many large surgical case series which have been references of text books and neurosurgical practice. Many of those series were investigated before stereotactic radiosurgery (SRS) practice were not so often or were in terms of WHO 2000 classification. In this study we aimed an update to the current literature by using WHO 2007 classification. MATERIAL AND METHODS: 488 intracranial meningioma patients underwent open surgery. All pathological specimens re-evaluated in terms of WHO 2007 classification...
August 5, 2016: Turkish Neurosurgery
https://www.readbyqxmd.com/read/27551550/vitamin-d-and-urological-cancers
#16
REVIEW
Wojciech Krajewski, Mateusz Dzięgała, Anna Kołodziej, Janusz Dembowski, Romuald Zdrojowy
INTRODUCTION: Vitamin D controls calcium and phosphate homeostasis. Additionally, it has been proven that vitamin D is an important modulator of cellular differentiation and proliferation in a number of normal and malignant cells. Vitamin D can regulate proliferation, apoptosis, and cell adhesion at the tumor cell level. It also modifies tumor angiogenesis, invasion, and metastasis and also decreases oxidative DNA damage. MATERIAL AND METHODS: The Medline and Web of Science databases were searched without time limit on October 2015 using the terms 'vitamin D' in conjunction with 'kidney cancer', 'bladder cancer', 'prostate cancer', and 'testis cancer'...
2016: Central European Journal of Urology
https://www.readbyqxmd.com/read/27462695/pattern-of-biliary-tract-carcinoma-at-the-university-college-hospital-ibadan
#17
T O Babatunde, J O Ogunbiyi
BACKGROUND: Biliary tract carcinomas are uncommon but highly fatal malignancies. Most patients in our environment are diagnosed late and are not candidates for curative resection. OBJECTIVE: To determine the pattern and risk factors of biliary tract carcinoma in Ibadan. METHODOLOGY: This was a retrospective study of histologically confirmed cases of biliary tract carcinoma diagnosed at the University College Hospital, Ibadan between January 1971 and December 20 10...
December 2015: African Journal of Medicine and Medical Sciences
https://www.readbyqxmd.com/read/27458458/of-amoebae-and-men-extracellular-dna-traps-as-an-ancient-cell-intrinsic-defense-mechanism
#18
Xuezhi Zhang, Thierry Soldati
Since the discovery of the formation of DNA-based extracellular traps (ETs) by neutrophils as an innate immune defense mechanism (1), hundreds of articles describe the involvement of ETs in physiological and pathological human and animal conditions [reviewed in Ref. (2), and the previous Frontiers Research Topic on NETosis: http://www.frontiersin.org/books/NETosis_At_the_Intersection_of_Cell_Biology_Microbiology_and_Immunology/195]. Interestingly, a few reports reveal that ETs can be formed by immune cells of more ancient organisms, as far back as the common ancestor of vertebrates and invertebrates (3)...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27432206/bicanalicular-silicone-stents-in-endonasal-dacryocystorhinostomy-results-of-a-randomized-clinical-trial
#19
RANDOMIZED CONTROLLED TRIAL
Tessa Fayers, Peter J Dolman
PURPOSE: To assess whether the use of silicone lacrimal stents affects the long-term success of endonasal dacryocystorhinostomy (EN-DCR). DESIGN: Prospective, randomized, controlled, interventional trial. PARTICIPANTS: The subjects were adult patients older than 16 years undergoing primary EN-DCR for nasolacrimal duct obstruction who gave fully informed consent and who had no lid malpositions or canalicular pathology. In cases with bilateral surgery, only the right eyes were studied...
October 2016: Ophthalmology
https://www.readbyqxmd.com/read/27381235/evolution-in-the-management-of-pediatric-and-adolescent-ovarian-torsion-as-a-result-of-quality-improvement-measures
#20
Nicole Hubner, Jacob Charles Langer, Sari Kives, Lisa Mary Allen
STUDY OBJECTIVE: The aim of this study was to document the change in ovarian conservation rate after ovarian torsion as a result of continuous quality improvement (CQI) measures, and to determine factors that contribute to this outcome. DESIGN: A retrospective, uncontrolled before-and-after study. SETTING: An academic children's hospital. PARTICIPANTS: Female adolescents younger than 18 years with surgically confirmed ovarian torsion from April 1, 1988 to October 15, 2013; excluding cases from 2003 (intervention period)...
February 2017: Journal of Pediatric and Adolescent Gynecology
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