Tianyi Zhao, Yu Zhang, Liangbo Liu, Xingmei Deng, Jia Guo, Shuzhu Cao, Dexin Zhu, Jian Xu, Usevich Vera Nikolaevna, Suleimenov Maratbek, Zhen Wang, Zhihua Sun, Xinli Gu, Hui Zhang
Human brucellosis is one of the world's most common zoonoses, caused by Brucella infection and characterized by induced inflammation, which in severe cases can lead to abortion and sterility in humans and animals. There is growing evidence that traditional Chinese medicine (TCM) is beneficial as an adjunct to the treatment of brucellosis. However, its specific targets of action and molecular mechanisms remain unclear. In this study, a systematic pharmacological approach was applied to demonstrate pharmacological targets, biological functions, and signaling pathways of TCM as an adjunct to the treatment of brucellosis (TCMTB)...
August 8, 2023: ACS Omega