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https://www.readbyqxmd.com/read/27670832/data-transparency-in-clinical-trials-implications-of-restoring-study-329
#1
Jon Jureidini
No abstract text is available yet for this article.
September 26, 2016: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/27662279/study-329-continuation-phase-safety-and-efficacy-of-paroxetine-and-imipramine-in-extended-treatment-of-adolescent-major-depression
#2
Joanna Le Noury, John M Nardo, David Healy, Jon Jureidini, Melissa Raven, Catalin Tufanaru, Elia Abi-Jaoude
OBJECTIVE: This is an analysis of the unpublished continuation phase of Study 329, the primary objective of which was to compare the efficacy and safety of paroxetine and imipramine with placebo in the treatment of adolescents with unipolar major depression. The objectives of the continuation phase were to assess safety and relapse rates in the longer term. The objective of this publication, under the Restoring Invisible and Abandoned Trials (RIAT) initiative, was to see whether access to and analysis of the previously unpublished dataset from the continuation phase of this randomized controlled trial would have clinically relevant implications for evidence-based medicine...
September 17, 2016: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/27289173/antidepressants-fail-but-no-cause-for-therapeutic-gloom
#3
COMMENT
Jon Jureidini
No abstract text is available yet for this article.
August 27, 2016: Lancet
https://www.readbyqxmd.com/read/27176755/the-citalopram-cit-md-18-pediatric-depression-trial-deconstruction-of-medical-ghostwriting-data-mischaracterisation-and-academic-malfeasance
#4
Jon N Jureidini, Jay D Amsterdam, Leemon B McHenry
OBJECTIVE: Deconstruction of a ghostwritten report of a randomized, double-blind, placebo-controlled efficacy and safety trial of citalopram in depressed children and adolescents conducted in the United States. METHODS: Approximately 750 documents from the Celexa and Lexapro Marketing and Sales Practices Litigation: Master Docket 09-MD-2067-(NMG) were deconstructed. RESULTS: The published article contained efficacy and safety data inconsistent with the protocol criteria...
March 16, 2016: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/26376805/restoring-study-329-efficacy-and-harms-of-paroxetine-and-imipramine-in-treatment-of-major-depression-in-adolescence
#5
RANDOMIZED CONTROLLED TRIAL
Joanna Le Noury, John M Nardo, David Healy, Jon Jureidini, Melissa Raven, Catalin Tufanaru, Elia Abi-Jaoude
OBJECTIVES: To reanalyse SmithKline Beecham's Study 329 (published by Keller and colleagues in 2001), the primary objective of which was to compare the efficacy and safety of paroxetine and imipramine with placebo in the treatment of adolescents with unipolar major depression. The reanalysis under the restoring invisible and abandoned trials (RIAT) initiative was done to see whether access to and reanalysis of a full dataset from a randomised controlled trial would have clinically relevant implications for evidence based medicine...
2015: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/25390273/let-children-cry
#6
Jon N Jureidini
No abstract text is available yet for this article.
November 17, 2014: Medical Journal of Australia
https://www.readbyqxmd.com/read/24024222/emerging-psychosis-in-adolescents-a-practical-guide
#7
Hsu-en Lee, Jon Jureidini
BACKGROUND: Emerging psychosis is a challenging presentation for the general practitioner as there is disagreement in the literature about classification and appropriate treatment protocols. OBJECTIVE: This paper highlights three main issues in primary care: recognising early signs of emerging psychosis, and how and when to refer patients; complexities associated with comorbid substance use; and management when the patient is referred back to primary care in the post-acute phase...
September 2013: Australian Family Physician
https://www.readbyqxmd.com/read/23814155/transparency-and-accountability-in-early-psychosis-intervention-research
#8
Melissa Raven, Jon Jureidini, Geoffrey W Stuart
No abstract text is available yet for this article.
July 2013: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/23814153/psychodynamic-minimalism
#9
Jon Jureidini
No abstract text is available yet for this article.
July 2013: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/23757196/combination-pharmacotherapy-for-psychiatric-disorders-in-children-and-adolescents-prevalence-efficacy-risks-and-research-needs
#10
REVIEW
Jon Jureidini, Anne Tonkin, Elsa Jureidini
Polypharmacy, defined as the concomitant use of two or more psychotropic drugs, has become increasingly common in the paediatric and adolescent population over the past two decades. Combining psychotropic drugs leads to possible increases in benefits, but also in risks, particularly given the potential for psychotropic drug interactions. Despite the increasing use of concomitant therapy in children and adolescents, there is very little evidence from controlled clinical trials to provide guidance for prescribers...
October 2013: Paediatric Drugs
https://www.readbyqxmd.com/read/23028192/healthy-kids-check-lack-of-transparency-and-misplaced-faith-in-the-benefits-of-screening
#11
Jon Jureidini, Melissa Raven
No abstract text is available yet for this article.
October 2012: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/22679201/key-opinion-leaders-in-psychiatry-a-conflicted-pathway-to-career-advancement
#12
EDITORIAL
Jon Jureidini
No abstract text is available yet for this article.
June 2012: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/22391276/explanations-and-unexplanations-restoring-meaning-to-psychiatry
#13
Jon Jureidini
No abstract text is available yet for this article.
March 2012: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/22247095/-prodromal-diagnosis-of-psychosis-ethical-problems-in-research-and-clinical-practice
#14
Melissa Raven, Geoffrey W Stuart, Jon Jureidini
No abstract text is available yet for this article.
January 2012: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/21806711/children-in-immigration-detention-a-case-of-reckless-mistreatment
#15
EDITORIAL
Jon Jureidini, Julian Burnside
No abstract text is available yet for this article.
August 2011: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/21559324/aripiprazole-in-the-maintenance-treatment-of-bipolar-disorder-a-critical-review-of-the-evidence-and-its-dissemination-into-the-scientific-literature
#16
REVIEW
Alexander C Tsai, Nicholas Z Rosenlicht, Jon N Jureidini, Peter I Parry, Glen I Spielmans, David Healy
BACKGROUND: Aripiprazole, a second-generation antipsychotic medication, has been increasingly used in the maintenance treatment of bipolar disorder and received approval from the U.S. Food and Drug Administration for this indication in 2005. Given its widespread use, we sought to critically review the evidence supporting the use of aripiprazole in the maintenance treatment of bipolar disorder and examine how that evidence has been disseminated in the scientific literature. METHODS AND FINDINGS: We systematically searched multiple databases to identify double-blind, randomized controlled trials of aripiprazole for the maintenance treatment of bipolar disorder while excluding other types of studies, such as open-label, acute, and adjunctive studies...
May 2011: PLoS Medicine
https://www.readbyqxmd.com/read/21287414/conflicted-medical-journals-and-the-failure-of-trust
#17
Jon N Jureidini, Leemon B McHenry
Journals are failing in their obligation to ensure that research is fairly represented to their readers, and must act decisively to retract fraudulent publications. Recent case reports have exposed how marketing objectives usurped scientific testing and compromised the credibility of academic medicine. But scant attention has been given to the role that journals play in this process, especially when evidence of research fraud fails to elicit corrective measures. Our experience with The Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP) illustrates the nature of the problem...
January 2011: Accountability in Research
https://www.readbyqxmd.com/read/20513850/the-increased-use-of-antidepressants-has-contributed-to-the-worldwide-reduction-in-suicide-rates
#18
Göran Isacsson, Charles L Rich, Jon Jureidini, Melissa Raven
Numerous ecological studies have shown an inverse association between antidepressant use and suicide rates and a smaller number of individual-based studies have shown an association between current antidepressant use and reduced suicide risk. Such evidence is often cited in support of the notion that antidepressants prevent suicide. However, more recently, the premises underlying this proposition, namely that suicide is caused by depression and that antidepressants relieve depression, have been challenged and the potential harm caused by antidepressants has been highlighted...
June 2010: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/19401619/key-opinion-leaders-and-paediatric-antidepressant-overprescribing
#19
EDITORIAL
Jon N Jureidini, Leemon B McHenry
No abstract text is available yet for this article.
2009: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/19388719/how-do-we-safely-treat-depression-in-children-adolescents-and-young-adults
#20
Jon Jureidini
Increasing concerns about the safety and efficacy of antidepressant drugs for children, adolescents and young adults have been countered by claims that reduced prescribing of antidepressants may have dangerous consequences. This leaves clinicians unsure as to how to weigh up the evidence and apply it to their patients. This paper promotes an approach of evaluating the evidence in each study according to the importance of the outcomes being measured in that study. It finds that on important measures such as mortality, hospitalization and quality of life, the evidence is unfavourable for antidepressants in this population...
2009: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
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