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Placenta extract

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https://www.readbyqxmd.com/read/29346438/colonization-of-the-cervicovaginal-space-with-gardnerella-vaginalis-leads-to-local-inflammation-and-cervical-remodeling-in-pregnant-mice
#1
Luz-Jeannette Sierra, Amy G Brown, Guillermo O Barilá, Lauren Anton, Carrie E Barnum, Snehal S Shetye, Louis J Soslowsky, Michal A Elovitz
The role of the cervicovaginal (CV) microbiome in regulating cervical function during pregnancy is poorly understood. Gardnerella vaginalis (G. vaginalis) is the most common bacteria associated with the diagnosis of bacterial vaginosis (BV). While BV has been associated with preterm birth (PTB), clinical trials targeting BV do not decrease PTB rates. It remains unknown if G. vaginalis is capable of triggering molecular, biomechanical and cellular events that could lead to PTB. The objective of this study was to determine if cervicovaginal colonization with G...
2018: PloS One
https://www.readbyqxmd.com/read/29336106/best-practice-perioperative-strategies-and-surgical-techniques-for-preventing-caesarean-section-surgical-site-infections-a-systematic-review-of-reviews-and-meta-analyses
#2
Elizabeth K Martin, Michael M Beckmann, Louise N Barnsbee, Kate A Halton, Katharina M D Merollini, Nicholas Graves
BACKGROUND: Surgical site infection (SSI) following caesarean section is a problem for women and health services. Caesarean section is a high volume procedure and the estimated incidence of SSI may be as high as 9%. OBJECTIVES: The objective of this study was to identify a suite of perioperative strategies and surgical techniques that reduce the risk of SSI following caesarean section. SEARCH STRATEGY: Six electronic databases were searched to systematically review literature reviews, systematic reviews and meta-analyses published from 2006 to 2016...
January 16, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29289287/development-of-matrix-solid-phase-dispersion-method-for-the-extraction-of-short-chain-chlorinated-paraffins-in-human-placenta
#3
Ying Wang, Wei Gao, Jing Wu, Huijin Liu, Yingjun Wang, Yawei Wang, Guibin Jiang
Chlorinated paraffins (SCCPs) are widely used worldwide, and they can be released into the environment during their production, transport, usage and disposal, which pose potential risks for human health. In this work, an efficient, reliable and rapid pretreatment method based on matrix solid-phase dispersion (MSPD) was developed for the analysis of short-chain CPs (SCCPs) in human placenta by gas chromatograph-electron capture negative ion low-resolution mass spectrometry (GC-ECNI-LRMS) and gas chromatography-quadrupole time-of-flight mass spectrometry (GC-QTOF-HRMS)...
December 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29277276/preliminary-metabolomics-analysis-of-placenta-in-maternal-obesity
#4
Claudia Fattuoni, Chiara Mandò, Francesco Palmas, Gaia Maria Anelli, Chiara Novielli, Estefanìa Parejo Laudicina, Valeria Maria Savasi, Luigi Barberini, Angelica Dessì, Roberta Pintus, Vassilios Fanos, Antonio Noto, Irene Cetin
INTRODUCTION: Metabolomics identifies phenotypical groups with specific metabolic profiles, being increasingly applied to several pregnancy conditions. This is the first preliminary study analyzing placental metabolomics in normal weight (NW) and obese (OB) pregnancies. METHODS: Twenty NW (18.5 ≤ BMI< 25 kg/m2) and eighteen OB (BMI≥ 30 kg/m2) pregnancies were studied. Placental biopsies were collected at elective caesarean section. Metabolites extraction method was optimized for hydrophilic and lipophilic phases, then analyzed with GC-MS...
January 2018: Placenta
https://www.readbyqxmd.com/read/29276183/the-reaction-of-placental-grp78-protein-with-sera-from-women-with-multiple-sclerosis
#5
Behrouz Gharesi-Fard, Maryam Zare, Eskandar Kamali-Sarvestani
BACKGROUND: Multiple Sclerosis (MS) with four different types is one of the well studied autoimmune diseases of the central nervous system. Generally, two-thirds of MS patients are females who are at risk of pregnancy-related complications. Inappropriate responses of mother's immune system, such as antibody production against placental proteins, may lead to pregnancy-related disorders. The association between pregnancy complications and some autoantibodies including anti-phospholipid and anti-angiotensin II type-1 receptor antibodies are clear examples in this regard...
December 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29241934/fetoplacental-cytogenetic-discrepancy-in-a-pregnancy-with-fetal-mosaic-tetrasomy-12p-and-pallister-killian-syndrome-detected-by-amniocentesis
#6
Chih-Ping Chen, Liang-Kai Wang, Schu-Rern Chern, Peih-Shan Wu, Shin-Wen Chen, Shih-Ting Lai, Tzu-Yun Chuang, Li-Feng Chen, Wayseen Wang
OBJECTIVE: We present fetoplacental cytogenetic discrepancy in a pregnancy with prenatally detected mosaic tetrasomy 12p by amniocentesis. CASE REPORT: A 34-year-old woman underwent amniocentesis at 17 weeks of gestation because of advanced maternal age. Cytogenetic analysis of cultured amniocytes revealed a karyotype of 47,XX,+i(12)(p10)[7]/46,XX[16]. Array comparative genomic hybridization (aCGH) analysis of the DNA extracted from cultured amniocytes revealed arr (12p)×3, (X)×2...
December 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29228803/in-vitro-human-placental-studies-to-support-an-adenovirus-mediated-vegf-d%C3%AE-n%C3%AE-c-maternal-gene-therapy-for-the-treatment-of-severe-early-onset-fetal-growth-restriction
#7
Michelle Desforges, Alexandra Rogue Rogue, Nick Pearson, Carlo Rossi, Elena Olearo, Roy Forster, Mark Lees, Neil Sebire, Susan Greenwood, Colin Sibley, Anna L David, Paul Brownbill
Severe fetal growth restriction (FGR) affects 1:500 pregnancies, is untreatable and causes serious neonatal morbidity and death. Reduced uterine blood flow (UBF) is one cause. Transduction of uterine arteries in normal and FGR animal models using an adenovirus (Ad) encoding VEGF isoforms, increases UBF and improves fetal growth in utero. Understanding potential adverse consequences of this therapy before first-in-woman clinical application is essential. OBJECTIVE: To determine whether Ad...
December 11, 2017: Human Gene Therapy. Clinical Development
https://www.readbyqxmd.com/read/29212380/%C3%AE-v%C3%AE-3-integrin-and-fibronectin-expressions-and-their-relation-to-estrogen-and-progesterone-during-placentation-in-swine
#8
C Vélez, C Barbeito, M Koncurat
Mammalian pregnancy requires specific interactions between the conceptus and its mother that involve the endocrine system and adhesion molecules. The relation between adhesion molecules and their ligands at the fetal-maternal interface is crucial for developing a successful implantation. Progesterone (P4) and estrogen (E2) secreted by the porcine conceptus are required for the relation to be established. We investigated the expression of αvβ3 integrin and its ligand, fibronectin (FN), at the placental interface, and E2 and P4 concentrations in both serum and maternal and fetal placental extracts during placentation in swine...
December 7, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/29185249/temporal-trends-of-postpartum-haemorrhage-in-switzerland-a-22-year-retrospective-population-based-cohort-study
#9
Andrea Kaelin Agten, Daniel Passweg, Stephanie von Orelli, Nancy Ringel, Ruedi Tschudi, Boris Tutschek
AIM: Postpartum haemorrhage (PPH) is one of the leading causes of maternal morbidity and mortality. Studies have reported an increase in incidence of postpartum haemorrhage in recent years. Our goal was to investigate changes in the incidence of postpartum haemorrhage (PPH) and its risk factors in Switzerland from 1993 to 2014. METHODS: This population-based retrospective cohort study used data from the national Swiss Hospital in-patient database for obstetric and gynaecological hospital admissions - "Arbeitsgemeinschaft Schweizer Frauenkliniken" (ASF Statistik)...
November 29, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29179589/aspirin-or-heparin-or-both-in-the-treatment-of-recurrent-spontaneous-abortion-in-women-with-antiphospholipid-antibody-syndrome-a-meta-analysis-of-randomized-controlled-trials
#10
Chang Lu, Yong Liu, Hai-Li Jiang
OBJECTIVE: This study was designed to evaluate the efficacy of aspirin or heparin or both in the treatment for recurrent spontaneous abortion (RSA) in women with antiphospholipid antibody syndrome (APS). METHODS: Systematic searches for randomized clinical trials (RCTs) evaluating on live birth and preterm delivery, preeclampsia, intrauterine growth restriction, gestational diabetes, bleeding of RSA with APS patients receiving aspirin and heparin therapy were carried out, from PubMed, EMBASE, ScienceDirect and CNKI...
November 27, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29163938/understanding-biological-mechanisms-underlying-adverse-birth-outcomes-in-developing-countries-protocol-for-a-prospective-cohort-amanhi-bio-banking-study
#11
Abdullah H Baqui, Rasheda Khanam, Mohammad Sayedur Rahman, Aziz Ahmed, Hasna Hena Rahman, Mamun Ibne Moin, Salahuddin Ahmed, Fyezah Jehan, Imran Nisar, Atiya Hussain, Muhammad Ilyas, Aneeta Hotwani, Muhammad Sajid, Shahida Qureshi, Anita Zaidi, Sunil Sazawal, Said M Ali, Saikat Deb, Mohammed Hamad Juma, Usha Dhingra, Arup Dutta, Shaali Makame Ame, Caroline Hayward, Igor Rudan, Mike Zangenberg, Donna Russell, Sachiyo Yoshida, Ozren Polašek, Alexander Manu, Rajiv Bahl
Objectives: The AMANHI study aims to seek for biomarkers as predictors of important pregnancy-related outcomes, and establish a biobank in developing countries for future research as new methods and technologies become available. Methods: AMANHI is using harmonised protocols to enrol 3000 women in early pregnancies (8-19 weeks of gestation) for population-based follow-up in pregnancy up to 42 days postpartum in Bangladesh, Pakistan and Tanzania, with collection taking place between August 2014 and June 2016...
December 2017: Journal of Global Health
https://www.readbyqxmd.com/read/29162979/association-of-tissue-specific-dna-methylation-alterations-with-%C3%AE-thalassemia-southeast-asian-deletion
#12
Tanapat Pangeson, Phanchana Sanguansermsri, Torpong Sanguansermsri, Teerapat Seeratanachot, Narutchala Suwanakhon, Metawee Srikummool, Worasak Kaewkong, Khwanruedee Mahingsa
In the wild-type allele, DNA methylation levels of 10 consecutive CpG sites adjacent to the upstream 5'-breakpoint of α-thalassemia Southeast Asian (SEA) deletion are not different between placenta and leukocytes. However, no previous study has reported the map of DNA methylation in the SEA allele. This report aims to show that the SEA mutation is associated with DNA methylation changes, resulting in differential methylation between placenta and leukocytes. Methylation-sensitive high-resolution analysis was used to compare DNA methylation among placenta, leukocytes, and unmethylated control DNA...
2017: Genetics & Epigenetics
https://www.readbyqxmd.com/read/29135079/cigarette-smoke-extract-and-isoprene-resulted-in-the-induction-of-apoptosis-and-autophagy-in-human-placenta-choriocarcinoma-jeg-3-cells
#13
Hae-Miru Lee, Kyung-Chul Choi
In this study, the effects of cigarette smoke (CS) on the induction of apoptosis via reactive oxygen species (ROS) production and endoplasmic reticulum stress (ER stress) of JEG-3 human choriocarcinoma cells were examined to confirm the relationship between CS and placenta development. Upon TUNEL assay, CS extract (3R4F; 0.3 and 2.1 μM) increased JEG-3 apoptosis. Western blot assay revealed that the protein expressions of p53, Bax, and CCAAT-enhancer-binding protein homologous protein (CHOP) increased, while the levels of Bcl-2 were reduced following CS extract treatment...
November 14, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29108633/preeclampsia-associates-with-reck-dependent-decrease-in-human-trophoblasts-migration-and-invasion
#14
Jaime Gutiérrez, Alejandro Aedo, Jacob Mora, Jorge Maldonado, Rocío Salsoso, Fernando Toledo, Marcelo Farías, Fabián Pardo, Andrea Leiva, Luis Sobrevia
INTRODUCTION: Preeclampsia is characterized by reduced invasion capacity of trophoblasts involving lower matrix metalloproteinase (MMP) activity. Cell invasion is reduced by reversion-inducing-cysteine-rich protein with Kazal motifs (RECK), a plasma membrane protein that inhibits MMP in several cell types. However, it is unknown whether this mechanism happens in the human placenta from preeclampsia. The hypothesis of this study sustains that RECK expression is increased leading to reduced trophoblasts invasion in preeclampsia...
November 2017: Placenta
https://www.readbyqxmd.com/read/29104621/abnormal-expression-of-microrna-575-leads-to-missed-abortion-through-regulating-apoptosis-and-angiogenesis
#15
Shuqin Xia, Yihui Zhen, Hongsheng Ma, Aiming Wang
Numerous microRNA (miR) are important for placental development and function. miR-575 has been demonstrated to be upregulated in maternal placenta in patients who have experienced a miscarriage. The present study aimed to explore the role of abnormal expression of miR-575 in missed abortion (MA) and to further analyze the potential molecular mechanisms. Embryo villus tissue samples were extracted from 10 childless women with MA and 10 fertile women without a history of MA. Additionally, human choriocarcinoma cells, JEG-3, were used in the present study, which were transfected with miR-575 mimic, inhibitor and scramble...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29083107/increased-mir-223-expression-in-foetal-organs-is-a-signature-of-acute-chorioamnionitis-with-systemic-consequences
#16
JoonHo Lee, Chong Jai Kim, Jung-Sun Kim, Deug-Chan Lee, Sejin Ahn, Bo Hyun Yoon
Acute chorioamnionitis, frequently observed in preterm placentas, is a major risk factor for the development of infection and non-infection-related adverse perinatal outcomes. MicroRNAs play important roles in immune cell development and function as well as in the development of cancers and neurologic diseases. We sought to investigate the changes in microRNA-223 (miR-223) expression and the functional significance of the changes in miR-223 expression in foetal organs in the presence of acute chorioamnionitis...
October 30, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29027680/determination-of-thiocyanate-as-a-biomarker-of-tobacco-smoke-constituents-in-selected-biological-materials-of-human-origin
#17
Sylwia Narkowicz, Ewa Jaszczak, Żaneta Polkowska, Bogumiła Kiełbratowska, Alicja Kotłowska, Jacek Namieśnik
In order to protect human health, it is necessary to biomonitor toxic substances originating from tobacco smoke in biological materials sampled from the persons with different exposures to tobacco smoke constituents. Thiocyanate anion is a biomarker of exposure to tobacco smoke components which is characterized by a relatively long half-life in the human body, i.e. 6 days. In this work, we present the results of thiocyanate determinations performed on the samples of placenta, meconium, saliva, breast milk, sweat and blood...
October 13, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29025835/the-climb-complex-lipids-in-mothers-and-babies-study-protocol-for-a-multicentre-three-group-parallel-randomised-controlled-trial-to-investigate-the-effect-of-supplementation-of-complex-lipids-in-pregnancy-on-maternal-ganglioside-status-and-subsequent-cognitive
#18
Shuai Huang, Ting-Ting Mo, Tom Norris, Si Sun, Ting Zhang, Ting-Li Han, Angela Rowan, Yin-Yin Xia, Hua Zhang, Hong-Bo Qi, Philip N Baker
INTRODUCTION: Complex lipids are important constituents of the central nervous system. Studies have shown that supplementation with complex milk lipids (CML) in pregnancy may increase the level of fetal gangliosides (GA), with the potential to improve cognitive outcomes. METHODS AND ANALYSIS: We aim to recruit approximately 1500 pregnant women in the first trimester (11-14 weeks) and randomise them into one of the three treatment groups: standard maternal milk formulation, CML-enhanced maternal milk formulation or no maternal milk intervention with standard pregnancy advice (ie, the standard care)...
October 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29025450/an-increase-in-rates-of-obstetric-haemorrhage-in-a-setting-of-high-hiv-seroprevalence
#19
E Shabalala, Hannah M Sebitloane
BACKGROUND: Obstetric haemorrhage (OH) is the leading cause of maternal mortality worldwide, although, indirectly, HIV is also a leading cause of maternal mortality in some settings with a high HIV seroprevalence. OBJECTIVE: To determine the possible association between increasing rates of OH and HIV or its treatment. METHODS: We conducted a retrospective chart review of women with OH at King Edward VIII Hospital, Durban, South Africa, over a 3-year period (2009 - 2011), during which the drug regimen for the prevention of mother-to-child transmission was evolving from single-dose nevirapine to antenatal zidovudine combined with intrapartum nevirapine (also referred to as dual therapy), and finally to a combination or highly active antiretroviral therapy (cART or HAART)...
June 30, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28964823/are-amniotic-fluid-neutrophils-in-women-with-intraamniotic-infection-and-or-inflammation-of-fetal-or-maternal-origin
#20
Nardhy Gomez-Lopez, Roberto Romero, Yi Xu, Yaozhu Leng, Valeria Garcia-Flores, Derek Miller, Suzanne M Jacques, Sonia S Hassan, Jonathan Faro, Adham Alsamsam, Ali Alhousseini, Hunter Gomez-Roberts, Bogdan Panaitescu, Lami Yeo, Eli Maymon
BACKGROUND: Neutrophils are the most abundant white blood cells found in the amniotic cavity of women with intraamniotic infection and/or inflammation. The current belief is that these neutrophils are of fetal origin. However, abundant neutrophils have been found in the amniotic fluid of women with a severe acute maternal inflammatory response but without a fetal inflammatory response in the placenta, suggesting that these innate immune cells can also be of maternal origin or a mixture of both fetal and maternal neutrophils...
September 28, 2017: American Journal of Obstetrics and Gynecology
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