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https://www.readbyqxmd.com/read/27732097/variables-affecting-the-long-term-outcome-of-graves-orbitopathy-following-high-dose-intravenous-glucocorticoid-pulse-therapy-in-patients-not-treated-with-orbital-radiotherapy
#1
Marenza Leo, Teresa Mautone, Ilaria Ionni, Maria Antonietta Profilo, Elena Sabini, Francesca Menconi, Barbara Mazzi, Roberto Rocchi, Francesco Latrofa, Marco Nardi, Paolo Vitti, Claudio Marcocci, Michele Marinò
OBJECTIVE: Intravenous (iv) glucocorticoids (GC) (ivGC) are used for active Graves orbitopathy (GO), but factors affecting GO outcome are poorly understood. We performed a retrospective study to investigate the variables affecting GO after ivGC. METHODS: We evaluated 83 consecutive GO patients treated with ivGC but not orbital radiotherapy (ORT) and re-examined them after a median of 47 months. The endpoints were the relationships between GO outcome or additional treatments with age, sex, smoking habits, thyroid volume, thyroid treatment, time since thyroid treatment, antithyroid-stimulating hormone receptor antibodies (TRAb), GO duration, GO features, and follow-up time...
October 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27465669/statins-are-not-a-risk-factor-for-liver-damage-associated-with-intravenous-glucocorticoid-pulse-therapy-for-graves-orbitopathy
#2
E Sabini, E Sisti, B Coco, M Leo, I Ionni, F Menconi, M A Profilo, B Mazzi, R Rocchi, F Latrofa, P Vitti, M Brunetto, C Marcocci, M Marinò
OBJECTIVE: Acute liver damage (ALD) is associated with high-dose intravenous (iv) glucocorticoid (GC) (ivGC) pulse therapy in ~1 % of patients for Graves' orbitopathy (GO). It has been proposed that statins may increase the risk of ALD. Here we investigated the frequency of ALD according to the assumption of statins in a large retrospective cohort study. METHODS: We studied 1076 consecutive patients with GO given ivGC. ALD was defined as an increase in alanine aminotransferase ≥300 U/l...
July 27, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27359290/variables-affecting-the-long-term-outcome-of-graves-orbitopathy-following-high-dose-intravenous-glucocorticoid-pulse-therapy-in-patients-not-treated-with-orbital-radiotherapy
#3
Marenza Leo, Teresa Mautone, Ilaria Ionni, Maria Antonietta Profilo, Elena Sabini, Francesca Menconi, Barbara Mazzi, Roberto Rocchi, Francesco Latrofa, Marco Nardi, Paolo Vitti, Claudio Marcocci, Michele Marinò
Objective Intravenous (iv) glucocorticoids (GC) (ivGC) are used for active Graves' orbitopathy (GO), but factors affecting GO outcome are poorly known. Here we performed a retrospective study aimed at investigating the variables affecting GO after ivGC. Methods We evaluated 83 consecutive GO patients treated with ivGC, but not with orbital radiotherapy, and re-examined them after a median period of 47 months. The end-points were the relation between GO outcome or additional treatments with age, gender, smoking, thyroid volume, thyroid treatment, time since thyroid treatment, TRAb, GO duration, GO features and follow-up time...
June 30, 2016: Endocrine Practice
https://www.readbyqxmd.com/read/26090805/age-and-dose-are-major-risk-factors-for-liver-damage-associated-with-intravenous-glucocorticoid-pulse-therapy-for-graves-orbitopathy
#4
Eleonora Sisti, Barbara Coco, Francesca Menconi, Marenza Leo, Roberto Rocchi, Francesco Latrofa, Maria Antonietta Profilo, Barbara Mazzi, Paolo Vitti, Claudio Marcocci, Maurizia Brunetto, Michele Marinò
BACKGROUND: High-dose intravenous glucocorticoid (ivGC) pulse therapy, which is commonly used for Graves' orbitopathy (GO), has been associated with acute liver damage (ALD), resulting in a fatal outcome in a few cases. No certain risk factors for ALD have been established. Consequently, a large retrospective cohort study was performed. METHODS: The relationship between ALD and several potential risk factors was assessed in 1076 consecutive patients with GO given ivGC...
July 2015: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/25661744/intravenous-glucocorticoid-therapy-for-graves-ophthalmopathy-and-acute-liver-damage-an-epidemiological-study
#5
Eleonora Sisti, Barbara Coco, Francesca Menconi, Marenza Leo, Roberto Rocchi, Francesco Latrofa, Maria Antonietta Profilo, Barbara Mazzi, Eleonora Albano, Paolo Vitti, Claudio Marcocci, Maurizia Brunetto, Michele Marinò
OBJECTIVE: Intravenous glucocorticoid (i.v.GC) pulse therapy for Graves' ophthalmopathy (GO) can be associated with acute liver damage (ALD), which was roughly estimated to occur in ∼1% of patients, with an overall mortality of 0.4%. The aim of this study was to evaluate the frequency of ALD after the introduction of a series of exclusion criteria and preventive measures. DESIGN: Retrospective evaluation of all consecutive patients candidate to i.v.GC over a period of 5 years...
March 2015: European Journal of Endocrinology
https://www.readbyqxmd.com/read/25596664/long-term-outcome-of-graves-orbitopathy-following-high-dose-intravenous-glucocorticoids-and-orbital-radiotherapy
#6
E Sisti, F Menconi, M Leo, M A Profilo, T Mautone, B Mazzi, R Rocchi, F Latrofa, M Nardi, P Vitti, C Marcocci, M Marinò
OBJECTIVE: Intravenous (iv) glucocorticoids (GC) (ivGC) and orbital radiotherapy (ORT) are commonly used in active Graves' orbitopathy (GO), with favorable outcomes in up to 80% of patients. However, little is known on the factors that may affect GO outcome in the long term, an issue that we investigated here. METHODS: We studied retrospectively 96 untreated patients with GO, identified out of 787 consecutive patients who came to our GO Clinic for a follow-up visit between September 2010 and June 2013...
June 2015: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/25584927/role-of-the-underlying-thyroid-disease-on-the-phenotype-of-graves-orbitopathy-in-a-tertiary-referral-center
#7
Marenza Leo, Francesca Menconi, Roberto Rocchi, Francesco Latrofa, Eleonora Sisti, Maria Antonietta Profilo, Barbara Mazzi, Eleonora Albano, Marco Nardi, Paolo Vitti, Claudio Marcocci, Michele Marinò
BACKGROUND: Clinically overt Graves' orbitopathy (GO) is associated with Graves' disease (GD) in approximately 95% of cases, whereas the remaining 5% is observed in patients with hypothyroid autoimmune thyroiditis (AT) or without overt thyroid dysfunction (euthyroid GO). However, it is not known whether there is a difference in terms of GO phenotype between patients with GD and those with hypothyroid AT or without thyroid dysfunction, and hence this is investigated here. METHODS: The study design was to evaluate retrospectively all consecutive patients with a recent manifestation of GO, seen at their first visit to a tertiary referral center over a period of 10 years...
March 2015: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/25118924/cross-cultural-adaptation-of-the-italian-version-of-the-voice-activity-participation-profile
#8
Gaetano Fava, Nico Paolo Paolillo, Gisele Oliveira, Mara Behlau
The Vocal Activity Participation Profile (VAPP), originally developed in English, is a self-assessment tool used to measure individuals' voice activity limitation and participation restriction. Based on the fact that the cultural/linguistic adaptation is an essential step of validating a protocol in another language, the purpose was to linguistically and culturally adapt the VAPP into Italian. The adaptation was performed in accordance to the Scientific Advisory Committee of the Medical Outcomes Trust. The translation was performed by one bilingual speech-language pathologist and by one bilingual interpreter, who knew about the purpose of this project...
May 2014: CoDAS
https://www.readbyqxmd.com/read/25008383/cross-cultural-adaptation-validation-and-cutoff-point-of-the-italian-version-of-the-voice-activity-and-participation-profile-profilo-di-attivit%C3%A3-e-partecipazione-vocale
#9
Gaetano Fava, Nico Paolo Paolillo, Gisele Oliveira, Mara Behlau
OBJECTIVES/HYPOTHESIS: The purpose of the study was to investigate the validity of the Profilo di Attività e Partecipazione Vocale (PAPV) and to identify the cutoff point of the total score that discriminates dysphonic from vocally healthy individuals. STUDY DESIGN: Cross-sectional, nonrandomized, prospective study with controls. METHODS: The PAPV was administered to 239 individuals, 108 with vocal complaint, 131 without vocal complaint, 141 female, 98 male, mean age of 45...
January 2015: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/23980907/spontaneous-improvement-of-untreated-mild-graves-ophthalmopathy-rundle-s-curve-revisited
#10
Francesca Menconi, Maria Antonietta Profilo, Marenza Leo, Eleonora Sisti, Maria Antonietta Altea, Roberto Rocchi, Francesco Latrofa, Marco Nardi, Paolo Vitti, Claudio Marcocci, Michele Marinò
BACKGROUND: According to Rundle's curve, Graves' ophthalmopathy (GO) worsens during an initial phase up to a peak of maximum severity, then improves and reaches a static plateau, with the activity curve preceding the severity curve by a few months. To our knowledge, no studies have tried to replicate Rundle's curve, and very few have investigated the natural history of GO. Here, we studied GO natural history retrospectively and tried to identify factors that may affect it. METHODS: A total of 65 patients with untreated GO underwent an eye assessment after a median of seven months after the appearance of GO and then after a median of 40 months...
January 2014: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/23088654/thyroid-volume-and-severity-of-graves-orbitopathy
#11
Maria Antonietta Profilo, Eleonora Sisti, Claudio Marcocci, Paolo Vitti, Aldo Pinchera, Marco Nardi, Roberto Rocchi, Francesco Latrofa, Francesca Menconi, Maria Antonietta Altea, Marenza Leo, Teresa Rago, Michele Marinò
BACKGROUND: Graves' orbitopathy (GO) is thought to be related to one or more autoantigens present in the thyroid and in orbital tissues. Although this may not imply a quantitative relation between thyroid antigens and degree of GO, which in turn is a risk factor for a more pronounced GO, we postulated that the severity of GO may parallel the amount of thyroid tissue, namely, the size of the thyroid gland. This hypothesis is also based on the observation that patients with Graves' disease presenting with large goiters tend to have more severe hyperthyroidism...
January 2013: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/22825439/-sviluppo-e-validazione-della-versione-italiana-della-dispositional-resilience-scale-a-15-item
#12
Angelo Picardi, Paul T Bartone, Raffaella Querci, Daniela Bitetti, Lorenzo Tarsitani, Valentina Roselli, Annalisa Maraone, Elisa Fabi, Francesco De Michele, Ilaria Gaviano, Brian Flynn, Robert Ursano, Massimo Biondi
RIASSUNTO. Vi sono evidenze che la solidità psicologica (Hardiness) è una risorsa importante per la resilienza allo stress. Vi è uno strumento autocompilato breve, affidabile e valido per misurare la "Hardiness", la versione a 15 item della Dispositional Resilience Scale (DRS-15), che non è tuttavia disponibile in italiano. Gli obiettivi di questo studio sono stati creare una versione italiana della DRS-15 e valutarne le sue proprietà psicometriche nel contesto italiano. La versione italiana della DRS-15 è stata prodotta con una procedura basata su traduttori multipli bilingui...
May 2012: Rivista di Psichiatria
https://www.readbyqxmd.com/read/22031515/outcome-of-graves-orbitopathy-after-total-thyroid-ablation-and-glucocorticoid-treatment-follow-up-of-a-randomized-clinical-trial
#13
RANDOMIZED CONTROLLED TRIAL
Marenza Leo, Claudio Marcocci, Aldo Pinchera, Marco Nardi, Loredana Megna, Roberto Rocchi, Francesco Latrofa, Maria Antonietta Altea, Barbara Mazzi, Eleonora Sisti, Maria Antonietta Profilo, Michele Marinò
CONTEXT: In a previous study, we found that total thyroid ablation (thyroidectomy plus (131)I) is associated with a better outcome of Graves' orbitopathy (GO) compared with thyroidectomy alone, as observed shortly (9 months) after glucocorticoid (GC) treatment. OBJECTIVE: The objective of the study was to evaluate the outcome of GO in the same patients of the previous study over a longer period of time. DESIGN: This was a follow-up of a randomized study...
January 2012: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/10010201/nonlinear-excitations-in-a-hamiltonian-spin-field-model-in-2-1-dimensions
#14
Martina, Profilo, Soliani, Solombrino
No abstract text is available yet for this article.
May 1, 1994: Physical Review. B, Condensed Matter
https://www.readbyqxmd.com/read/9979076/two-extended-versions-of-the-continuous-two-dimensional-heisenberg-model
#15
Alfinito, Profilo, Soliani
No abstract text is available yet for this article.
February 1, 1995: Physical Review. B, Condensed Matter
https://www.readbyqxmd.com/read/9906174/group-theoretical-approach-to-the-classical-and-quantum-oscillator-with-time-dependent-mass-and-frequency
#16
Profilo, Soliana
No abstract text is available yet for this article.
August 1, 1991: Physical Review. A
https://www.readbyqxmd.com/read/8507790/thermal-behaviour-of-hydroxyapatite-intended-for-medical-applications
#17
B Locardi, U E Pazzaglia, C Gabbi, B Profilo
Four commercial hydroxyapatites (both natural and synthetic) were tested to assess transformations of the chemical and crystalline structure following variation of temperature from 20 to 1600 degrees C. The thermal behaviour of hydroxyapatite is relevant for biomedical applications such as plasma spraying of metallic implants. Thermogravimetric analysis showed a weight loss from each hydroxyapatite specimen, due to a release of structural H2O molecules; all the specimens up to 1300 degrees C were made of crystalline hydroxyapatite, determined by X-ray diffraction; at 1470 degrees C they were made of both hydroxyapatite and calcium phosphate, but at 1570 degrees C of calcium phosphate exclusively...
May 1993: Biomaterials
https://www.readbyqxmd.com/read/2396339/-bladder-neck-sclerosis-in-children
#18
COMPARATIVE STUDY
A G Pugachev, Iu V Kudriavtsev, S A Kozlov, V P Osipov, G V Ovsiannikova
Nowadays there are contradictory opinions of the prevalence of urinary cervicovesical sclerosis in children and therefore the high incidence of the disease is explained by some investigators as hyperdiagnosis. This article presents the results of examination performed in 15 children with urinary cervicovesical sclerosis who were referred to hospital for other diagnoses. Morphological examination, including electron microscopy, failed to demonstrate the congenital origin of the disease. The authors suspect that the development of cervicovesical sclerosis in children was associated with some secondary reasons...
May 1990: Urologii︠a︡ i Nefrologii︠a︡
https://www.readbyqxmd.com/read/1292325/a-multi-allergen-elisa-screening-method-comparison-with-pharmacia-cap-system-and-phazet-skin-prick-test
#19
COMPARATIVE STUDY
A Scordamaglia, G Passalacqua, P Pisati, G Moscato, R Bertoletti, S Ruffoni, G W Canonica
Eighty consecutive subjects, coming to our service as suffering from conjunctivitis and/or rhinitis and/or asthma, were investigated by a new multi-allergen enzymatic screening immunoassay (Profilo, Bio-Allergy, Rome, Italy) regarding to serum specific IgE for groups of inhalant allergens (Dermatophagoides, Parietaria, grasses, trees, animal danders). These groups include allergens which are most frequently responsible of allergy in our country. Indices of diagnostic accuracy of this assay were analyzed in relation to skin prick test (SPT, Phazet, Pharmacia), as in vivo reference test, and Pharmacia CAP System, as in vitro reference test, comparing the results achieved by these tests in the same group of subjects...
September 1992: Allergologia et Immunopathologia
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