Moumita Rakshit, Anastasia Darwitan, Aristo Muktabar, Prativa Das, Luong T H Nguyen, Ye Cao, Catarina Vizetto-Duarte, Jinkai Tang, Yee Shan Wong, Subbu Venkatraman, Kee Woei Ng
Atherosclerosis is a multifactorial disease triggered and sustained by risk factors such as high cholesterol, high blood pressure and unhealthy lifestyle. Inflammation plays a pivotal role in atherosclerosis pathogenesis. In this study, we developed a simvastatin (STAT) loaded nanoliposomal formulation (LIPOSTAT) which can deliver the drug into atherosclerotic plaque, when administered intravenously. This formulation is easily prepared, stable, and biocompatible with minimal burst release for effective drug delivery...
October 2021: Nanomedicine: Nanotechnology, Biology, and Medicine