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https://www.readbyqxmd.com/read/28420082/can-early-rehabilitation-prevent-posttraumatic-osteoarthritis-in-the-patellofemoral-joint-after-anterior-cruciate-ligament-rupture-understanding-the-pathological-features
#1
Nai-Jen Chang, Ming-You Shie, Kuan-Wei Lee, Pei-Hsi Chou, Chih-Chan Lin, Chih-Jou Chu
Knee instability resulting from anterior cruciate ligament (ACL) rupture is a high-risk factor for posttraumatic osteoarthritis (PTOA) in the patellofemoral joint (PFJ). However, whether non-weight-bearing and weight-bearing treatments have chondroprotective effects remains unclear. Twenty-four adult New Zealand White male rabbits were employed in this study. All animals received ACL transection in the right knee and sham surgery in the left knee. The rabbits were randomly assigned to the following groups: (I) In the sedentary (SED) group, the rabbits (n = 6) were simply kept in their cage; (II) In the continuous passive motion (CPM) group, the rabbits (n = 6) performed CPM exercise for 7 days, starting from the first postoperative day; (III) In the active treadmill exercise (TRE) group, the rabbits (n = 6) performed TRE for 2 weeks; (IV) In the CPM + TRE group, the rabbits (n = 6) executed CPM exercise, followed by TRE...
April 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28387161/biomechanical-assessment-of-the-dorsal-spanning-bridge-plate-in-distal-radius-fracture-fixation-implications-for-immediate-weight-bearing
#2
Jerry I Huang, Bret Peterson, Kate Bellevue, Nicolas Lee, Sean Smith, Safa Herfat
BACKGROUND: The goal of this study was to compare the biomechanical stability of a 2.4-mm dorsal spanning bridge plate with a volar locking plate (VLP) in a distal radius fracture model, during simulated crutch weight-bearing. METHODS: Five paired cadaveric forearms were tested. A 1-cm dorsal wedge osteotomy was created to simulate an unstable distal radius fracture with dorsal comminution. Fractures were fixed with a VLP or a dorsal bridge plate (DBP). Specimens were mounted to a crutch handle, and optical motion-tracking sensors were attached to the proximal and distal segments...
April 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28384558/temporary-total-hip-arthroplasty-like-spacer-for-treating-an-infected-periprosthetic-femoral-fracture-using-a-long-stem-a-case-report
#3
Youngwoo Kim, Yoshiaki Katsura, Nina Kasahara, Takashi Kasahara, Masashi Kanamura, Keiichi Kawanabe
INTRODUCTION: Infected periprosthetic femoral fractures are among the most complex and significant complications of total hip arthroplasty (THA). We report the novel use of a temporary THA-like spacer for treating an infected periprosthetic femoral fracture after revision surgery using a long stem. CASE PRESENTATION: We present a 72-year-old woman sustained a left infected periprosthetic femoral fracture after revi - streptococci in the culture sample. On suspicion of a periprosthetic joint infection, we planned a two-stage procedure...
March 22, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28383765/new-opportunities-for-fracture-healing-detection-impedance-spectroscopy-measurements-correlate-to-tissue-composition-in-fractures
#4
Monica C Lin, Frank Yang, Safa T Herfat, Chelsea S Bahney, Meir Marmor, Michel M Maharbiz
Accurate evaluation of fracture healing is important for clinical decisions on when to begin weight-bearing and when early intervention is necessary in cases of fracture nonunion. While the stages of healing involving hematoma, cartilage, trabecular bone, and cortical bone have been well characterized histologically, physicians typically track fracture healing by using subjective physical examinations and radiographic techniques that are only able to detect mineralized stages of bone healing. This exposes the need for a quantitative, reliable technique to monitor fracture healing, and particularly to track healing progression during the early stages of repair...
April 6, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28378562/early-rehabilitation-in-elderly-after-arthroplasty-versus-internal-fixation-for-unstable-intertrochanteric-fractures-of-femur-systematic-review-and-meta-analysis
#5
Jun Il Yoo, Yong Chan Ha, Jae Young Lim, Hyun Kang, Byung Ho Yoon, Hyunho Kim
The purpose of this study was to compare the outcomes focusing on the functional outcome and clinical results of replacement arthroplasty (AP) vs. internal fixation (IF) for the treatment of unstable intertrochanteric femoral fracture in elderly. Systematic review and meta-analysis were performed on 10 available clinical studies (2 randomized controlled trials and 8 comparative studies). Subgroup analysis was performed by type of methodological quality. Partial weight bearing time in AP group was earlier than that in IF group (SMD = -0...
May 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28373726/use-of-an-elastic-transarticular-external-fixator-construct-for-immobilization-of-the-elbow-joint
#6
Bertrand Vedrine
Transarticular external skeletal fixation usually involves rigid bars that result in a stable but stiff joint. This study describes the technique and the outcome of an elastic transarticular external fixator (ETEF) applied to the elbow joint. Four cases of elbow luxation with collateral ligament injuries were managed with closed reduction and application of an ETEF to maintain the reduction. A triceps tendon avulsion was surgically managed before applying an ETEF. The clinical outcome was considered excellent in 2 cats, good in 2 dogs (1 elbow luxation and the avulsion of the triceps tendon), and poor in 1 dog presented for elbow luxation and a permanent neurological defect...
April 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28365529/giant-cell-tumour-of-bone-in-the-denosumab-era
#7
REVIEW
Lizz van der Heijden, P D Sander Dijkstra, Jean-Yves Blay, Hans Gelderblom
Giant cell tumour of bone (GCTB) is an intermediate locally aggressive primary bone tumour, occurring mostly at the meta-epiphysis of long bones. Overexpression of receptor activator of nuclear factor kappa-B ligand (RANKL) by mononuclear neoplastic stromal cells promotes recruitment of numerous reactive multinucleated osteoclast-like giant cells, causing lacunar bone resorption. Preferential treatment is curettage with local adjuvants such as phenol, alcohol or liquid nitrogen. The remaining cavity may be filled with bone graft or polymethylmethacrylate (PMMA) bone cement; benefits of the latter are a lower risk of recurrence, possibility of direct weight bearing and early radiographic detection of recurrences...
March 30, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28361194/-lapidus-arthrodesis
#8
C Plaaß, L Claaßen, S Ettinger, K Daniilidis, C Stukenborg-Colsman
The tarso-metatarsal 1 joint (TMT-I) arthrodesis is a treatment option or moderate to severe hallux valgus (HV) deformities. Instability of the TMT1 joint is still a debatable indication. Using stable osteosynthesis techniques allows early postoperative weight bearing. Plantar plating combined with a lag screw is the biomechanical most stable construct. An additional intermetatarsal screw can improve the horizontal stability. Clinical results are good and radiological parameters stay constant, even in the long term...
March 30, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28334158/the-impact-of-pregnancy-on-taste-function
#9
Ezen Choo, Robin Dando
It is common for women to report a change in taste (for instance an increased bitter or decreased sweet response) during pregnancy, however specifics of any variation in taste with pregnancy remain elusive. Here we review studies of taste in pregnancy, and discuss how physiological changes occurring during pregnancy may influence taste signaling. We aim to consolidate studies of human pregnancy and "taste function" (studies of taste thresholds, discrimination, and intensity perception, rather than hedonic response or self-report), discussing differences in methodology and findings...
May 1, 2017: Chemical Senses
https://www.readbyqxmd.com/read/28324865/biomaterials-for-intervertebral-disc-regeneration-and-repair
#10
REVIEW
Robert D Bowles, Lori A Setton
The intervertebral disc contributes to motion, weight bearing, and flexibility of the spine, but is susceptible to damage and morphological changes that contribute to pathology with age and injury. Engineering strategies that rely upon synthetic materials or composite implants that do not interface with the biological components of the disc have not met with widespread use or desirable outcomes in the treatment of intervertebral disc pathology. Here we review bioengineering advances to treat disc disorders, using cell-supplemented materials, or acellular, biologically based materials, that provide opportunity for cell-material interactions and remodeling in the treatment of intervertebral disc disorders...
March 15, 2017: Biomaterials
https://www.readbyqxmd.com/read/28323121/the-treatment-of-intermediate-stage-tumour-beyond-tace-from-surgery-to-systemic-therapy
#11
REVIEW
Peter R Galle, Francesco Tovoli, Friedrich Foerster, Marcus A Wörns, Alessandro Cucchetti, Luigi Bolondi
Intermediate stage hepatocellular carcinoma (HCC) comprises the largest subgroup of patients with this disease and is characterized by substantial heterogeneity. Functional liver impairment, total tumour burden and other prognostic factors such as high alpha-fetoprotein serum level, presence of micro-vascular invasion, and poorly differentiated tumours relevantly contribute to outcome. The usage of the standard therapeutic approach, transarterial chemoembolization - TACE, for all intermediate stage HCC patients is probably an over-simplification and may therefore not be appropriate for all patients...
March 17, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28320425/patient-compliance-with-touchdown-weight-bearing-after-microfracture-treatment-of-talar-osteochondral-lesions
#12
Gökhan Polat, Gökhan Karademir, Ekin Akalan, Mehmet Aşık, Mehmet Erdil
BACKGROUND: The aim of this study was to prospectively evaluate the compliance of our patients with a touchdown weight bearing (without supporting any weight on the affected side by only touching the plantar aspect of the foot to the ground to maintain balance to protect the affected side from mechanical loading) postoperative rehabilitation protocol after treatment of talar osteochondral lesion (TOL). METHODS: Fourteen patients, who had been treated with arthroscopic debridement and microfracture, were followed prospectively...
March 20, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28291142/lower-extremity-avulsion-fractures-in-the-pediatric-and-adolescent-athlete
#13
Jonathan Schiller, Steven DeFroda, Travis Blood
Lower extremity avulsion fractures are uncommon in the pediatric population and can be misdiagnosed without proper imaging and/or clinical suspicion for these injuries. The most common locations of avulsion injuries are the ischial tuberosity, anterior superior iliac spine, and anterior inferior iliac spine. Less often, avulsion fractures occur in the tibial tubercle, calcaneus, and greater and lesser trochanters. When treated properly with rest and altered weight bearing, most of these injuries heal without complication...
April 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28290112/protecting-bone-health-in-pediatric-rheumatic-diseases-pharmacological-considerations
#14
REVIEW
Yujuan Zhang, Diana Milojevic
Bone health in children with rheumatic conditions may be compromised due to several factors related to the inflammatory disease state, delayed puberty, altered life style, including decreased physical activities, sun avoidance, suboptimal calcium and vitamin D intake, and medical treatments, mainly glucocorticoids and possibly some disease-modifying anti-rheumatic drugs. Low bone density or even fragility fractures could be asymptomatic; therefore, children with diseases of high inflammatory load, such as systemic onset juvenile idiopathic arthritis, juvenile dermatomyositis, systemic lupus erythematosus, and those requiring chronic glucocorticoids may benefit from routine screening of bone health...
March 13, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28276202/safety-osseointegration-and-bone-ingrowth-analysis-of-pmma-based-porous-cement-on-animal-metaphyseal-bone-defect-model
#15
Bruno Cimatti, Mariana Avelino Dos Santos, Maria Sol Brassesco, Laura Tiemi Okano, Wendell Monteiro Barboza, Marcello Henrique Nogueira-Barbosa, Edgard Eduard Engel
Bone defects created after curettage of benign bone tumors are customarily filled with solid poly(methyl methacrylate) (PMMA) or other bone substitutes. In this study, we depicted a porous PMMA-based cement (produced by mixing sodium bicarbonate and citric acid) and evaluated the prospect of its clinic application. Cement samples were characterized by high-performance liquid chromatography (HPLC) coupled to mass spectrometry and its cytotoxicity evaluated in fibroblast cultures. Implantation in rabbits allowed the histologic analysis of bone, kidneys, and liver for toxicity and coagulation tests, and MRI images for hemostasis evaluation...
March 9, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28257676/acute-achilles-tendon-rupture-clinical-evaluation-conservative-management-and-early-active-rehabilitation
#16
REVIEW
Merrell Kauwe
The Achilles tendon (AT) is the strongest, largest, and most commonly ruptured tendon in the human body. Physical examination provides high sensitivity and specificity. Imaging studies are not recommended unless there are equivocal findings in the physical examination. Recent studies have shown that the risk of re-rupture is negated with implementation of functional rehabilitation protocols. Heterogeneity in study design makes conclusions on the specifics of functional rehabilitation protocols difficult; however, it is clear that early weight bearing and early controlled mobilization lead to better patient outcome and satisfaction in both surgically and conservatively treated populations...
April 2017: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/28255659/an-intact-fibula-may-contribute-to-allow-early-weight-bearing-in-surgically-treated-tibial-plateau-fractures
#17
Ion Carrera, Pablo Eduardo Gelber, Gaetan Chary, Mireia Gomez Masdeu, Miguel A González Ballester, Juan Carlos Monllau, Jerome Noailly
PURPOSE: The role of the proximal tibiofibular joint (PTFJ) in tibial plateau fractures is unknown. The purpose of this study was to assess, with finite-element (FE) calculations, differences in interfragmentary movement (IFM) in a split fracture of lateral tibial plateau, with and without intact fibula. It was hypothesized that an intact fibula could positively contribute to the mechanical stabilization of surgically reduced lateral tibial plateau fractures. METHODS: A split fracture of the lateral tibial plateau was recreated in an FE model of a human tibia...
March 3, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28255341/proton-mr-spectroscopy-and-diffusion-mr-imaging-monitoring-to-predict-tumor-response-to-interstitial-photodynamic-therapy-for-glioblastoma
#18
Magali Toussaint, Sophie Pinel, Florent Auger, Nicolas Durieux, Magalie Thomassin, Eloise Thomas, Albert Moussaron, Dominique Meng, François Plénat, Marine Amouroux, Thierry Bastogne, Céline Frochot, Olivier Tillement, François Lux, Muriel Barberi-Heyob
Despite recent progress in conventional therapeutic approaches, the vast majority of glioblastoma recur locally, indicating that a more aggressive local therapy is required. Interstitial photodynamic therapy (iPDT) appears as a very promising and complementary approach to conventional therapies. However, an optimal fractionation scheme for iPDT remains the indispensable requirement. To achieve that major goal, we suggested following iPDT tumor response by a non-invasive imaging monitoring. Nude rats bearing intracranial glioblastoma U87MG xenografts were treated by iPDT, just after intravenous injection of AGuIX® nanoparticles, encapsulating PDT and imaging agents...
2017: Theranostics
https://www.readbyqxmd.com/read/28247009/treatment-of-acetabular-fractures-in-older-patients-introduction-of-a-new-implant-for-primary-total-hip-arthroplasty
#19
H Resch, D Krappinger, P Moroder, A Auffarth, M Blauth, J Becker
BACKGROUND: Fractures of the acetabulum in younger patients are commonly treated by open reduction and internal fixation. For elderly patients, stable primary total hip arthroplasty with the advantage of immediate postoperative mobilization might be the adequate treatment. For this purpose, a sufficiently stable fixation of the acetabular component is required. MATERIALS AND METHODS: Between August 2009 and 2014, 30 cases were reported in which all patients underwent total hip arthroplasty additionally to a customized implant designed as an antiprotrusion cage...
April 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28236603/computational-modelling-of-bone-fracture-healing-under-partial-weight-bearing-exercise
#20
Lihai Zhang, Saeed Miramini, Martin Richardson, Peter Ebeling, David Little, Yi Yang, Zhiyong Huang
A great deal of evidence suggests that partial weight-bearing exercise plays an important role in bone fracture healing. However, current physiotherapy program tends to follow the "Let's try it and see" strategy due to the lack of a fundamental understanding of in vivo mechanical environment required for the better healing outcomes. The purpose of present study is to develop an innovative framework to predict the healing outcomes as a result of post-surgical physical therapy. The raw acceleration data corresponding to a series of walking tests is firstly captured by ActiGraph accelerometers, and then used as input to theoretically estimate the peak ground reaction force (PGRF) and peak loading rate (PLR)...
February 21, 2017: Medical Engineering & Physics
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