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Early Weight bearing

Laurens De Cock, Jan Dauwe, Lukas A Holzer, Johan Bellemans
PURPOSE: Weight-bearing sports might influence the alignment of the lower extremities during growth. The relationship between participation in weight-bearing sports and the alignment of the lower extremities in adolescents has not been adequately studied yet. The aim of the study was to investigate whether sports participation during growth in early adolescence is correlated with the development of genu varum. METHODS: The design was a correlation study in which 1008 (564 boys, 444 girls) healthy adolescents (from 12 to 19 years of age) were recruited in secondary schools...
June 15, 2018: International Orthopaedics
Yipeng Lin, Tao Li, Yan Xiong, Jian Li, Weili Fu
Objective: To summarize the research progress of rehabilitation after autologous chondrocyte implantation (ACI). Methods: The literature related to basic science and clinical practice about rehabilitation after ACI in recent years was searched, selected, and analyzed. Results: Based on the included literature, the progress of the graft maturation consists of proliferation phase (0-6 weeks), transition phase (6-12 weeks), remodeling phase (12-26 weeks), and maturation phase (26 weeks-2 years)...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
Li-Feng Zhai, Gou-Ping Ma, Li-Feng Shen, Qiao-Feng Guo, Chun Zhang
OBJECTIVE: To explore the methods and results of modified one-stage revision procedure for treating proximal femoral infected nonunion after intramedullary nail fixation. METHODS: From June 2010 to June 2015, 10 patients of proximal femoral infected nonunion after intramedullary nail fixation were treated with modified one-stage revision procedure, including 9 males and 1 female, ranging in age from 35 to 77 years old. There were 3 cases of intertrochanteric fractures, 2 cases of intertrochanteric fractures accompanied with proximal femoral fractures and 5 cases of subtrochaneric fracures...
May 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Mandeep S Dhillon, Balvinder Rana, Inayat Panda, Sandeep Patel, Prasoon Kumar
Avascular necrosis (AVN) of the talus can be a cause of significant disability and is a difficult problem to treat. The most common cause is a fracture of the talus. We have done a systematic review of the literature with the following aims: (1) identify and summarize the available evidence in literature for the treatment of talar AVN, (2) define the usefulness of radiological Hawkins sign and magnetic resonance imaging in early diagnosis, and (3) provide patient management guidelines. We searched MEDLINE and PUBMED using keywords and MESH terminology...
May 2018: Indian Journal of Orthopaedics
Thiago J Izzo, Maria Teresa Fernandez Piedade, Wesley Dáttilo
Background and Aims: Even when adapted to flooding environments, the spatial distribution, growing strategies and anti-herbivore defences of plants face stressful conditions. Here we describe the effects of flooding on carbon allocation on growth, domatia and leaf production, and the herbivory on the myrmecophyte domatia-bearing Tococa coronata Benth. (Melastomataceae) growing along river banks in the Amazon region. Methods: In an area of 80 000 m2 of riparian forest along the Juruena River we actively searched for individuals of T...
June 7, 2018: Annals of Botany
Christian Kammerlander, Daniel Pfeufer, Leonard Adolf Lisitano, Stefan Mehaffey, Wolfgang Böcker, Carl Neuerburg
BACKGROUND: For elderly trauma patients, a basic goal is early mobilization, as immobilization can trigger various complications, such as venous thromboembolism, pneumonia, urinary tract infections, and pressure ulcers. Although partial weight-bearing has been shown to significantly increase mortality compared with unrestricted weight-bearing, it remains a frequent recommendation of aftercare following lower-extremity fracture fixation. METHODS: An insole force sensor was used to measure true postoperative weight-bearing by patients ≥75 years of age treated for hip fracture compared with patients 18 to 40 years of age treated for ankle fracture...
June 6, 2018: Journal of Bone and Joint Surgery. American Volume
Rachael Watson Levings, Ted A Broome, Andrew D Smith, Brett L Rice, Eric P Gibbs, D Alex Myara, E Viktoria Hyddmark, Elham Nasri, Ali Zarezadeh, Padraic P Levings, Yuan Lu, E Anthony Dacanay, Gregory B Foremny, Christopher H Evans, Alison J Morton, Mathew Winter, Michael J Dark, David M Nickerson, Patrick T Colahan, Steven Craig Ghivizzani
142: Toward the treatment of osteoarthritis (OA), we have been investigating self-complementary adeno-associated virus (scAAV) for intra-articular delivery of gene products with therapeutic potential. As OA frequently affects weight-bearing joints, we performed pharmacokinetic studies in the equine forelimb to identify parameters of scAAV gene delivery relevant to clinical translation. Using the coding sequence for interleukin-1 receptor antagonist (IL-1Ra) as a secreted therapeutic reporter we first generated an scAAV vector containing an optimized cDNA for equine IL-1Ra...
June 5, 2018: Human Gene Therapy. Clinical Development
Clarissa Matheis, Thomas Stöggl
STUDY DESIGN: Randomized controlled trial. OBJECTIVES: To improve hip function by an additional targeted mobilization and strength training of the hip muscles within the first postoperative week following a total hip arthroplasty (THA) in contrast to standard physiotherapy. BACKGROUND: The aim of early postoperative physiotherapy is to improve the functioning of the artificial hip joint as well as the restoration of mobility and independence of the patient...
April 2018: Journal of Bodywork and Movement Therapies
Ziyu Han, Wenting Shang, Xiaoyuan Liang, Hao Yan, Min Hu, Li Peng, Hongmei Jiang, Chihua Fang, Kun Wang, Jie Tian
PURPOSE: Pancreatic cancer is still associated with a poor outcome and low patient quality of life, which are mainly attributed to the late detection and requirement of distal pancreatectomy with extended resection of pancreatic tumors. Therefore, novel strategies for early screening and precise tumor resection are urgently needed. In this study, we evaluated the feasibility of a low-density lipoprotein receptor (LDLR)-targeted small-molecule contrast agent (peptide-22-Cy7) for early screening with photoacoustic tomography and near-infrared (NIR) imaging as guided surgical navigation to achieve precise resection...
June 1, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
F K Massen, S F Baumbach, W Böcker, C Kammerlander, V Herterich, H Polzer
Fractures to the anterior process of the calcaneus (PAC) have long been considered rare injuries and have received little attention in clinical research. On the contrary, recent studies have reported a distinct higher incidence, especially following ankle sprains. Decisive reasons are that fractures of the PAC are regularly missed on plain radiographs and that a clinical differentiation from injuries to the lateral ankle ligaments is difficult. With the broad availability of cross-sectional imaging modalities fractures of the PAC are diagnosed more frequently and more reliably...
May 29, 2018: Der Unfallchirurg
Imran Ratanshi, Tod A Clark, Jennifer L Giuffre
Intraneural ganglion cysts, which occur within the common peroneal nerve, are a rare cause of foot drop. The current standard of treatment for intraneural ganglion cysts involving the common peroneal nerve involves (1) cyst decompression and (2) ligation of the articular nerve branch to prevent recurrence. Nerve transfers are a time-dependent strategy for recovering ankle dorsiflexion in cases of high peroneal nerve palsy; however, this modality has not been performed for intraneural ganglion cysts involving the common peroneal nerve...
May 2018: Plastic Surgery
Laura Pasetto, Davide Olivari, Giovanni Nardo, Maria Chiara Trolese, Caterina Bendotti, Rosanna Piccirillo, Valentina Bonetto
Muscle wasting occurs during various chronic diseases and precedes death in humans as in mice. The evaluation of the degree of muscle atrophy in diseased mouse models is often overlooked since it requires the sacrifice of the animals for muscle examination or expensive instrumentation and highly qualified personnel, such as Magnetic Resonance Imaging (MRI). Very often behavioral tests for muscle strength evaluation are used as an outcome measurement in preclinical therapeutic trials. However, these tests are easy to perform serially, but not enough sensitive to detect early muscle changes during disease progression...
2018: PloS One
Tori M Stone, Jonathan E Wingo, John C Young, James W Navalta
Weight-bearing physical activity can optimize bone mass early in life and prevent the development of osteoporosis. However, less is known about the potential benefits of non-weight-bearing activities. The purpose of this study was to assess the efficacy of structured physical activity classes on bone metabolism. Twenty-eight premenopausal women, aged 18-35 years who were either enrolled in a yoga class (n=14) or cardio-kickboxing class (n=14) voluntarily consented to participate. Both classes were introductory classes meeting twice per week for 50 min per session for 12 weeks...
2018: International Journal of Exercise Science
Hao-Jiang Zuo, Shan Liu, Chun Yan, Li-Man Li, Xiao-Fang Pei
OBJECTIVE: To examine the effect of the aqueous extract of Ligustrum robustum on tumor growth in vitro and in vivo and explore the possible molecular mechanisms. METHODS: In in vitro study, cell viabilities of human cervical carcinoma cells (HeLa), human breast cancer cells (MCF-7), human prostate cancer cells (PC-3), human hepatoma cells (7721) and human colon carcinoma cells (SW480) were evaluated with cell counting kit-8. For L. robustum-treated Hela cells, early or late apoptosis were evaluated by annexin V/PI staining...
May 22, 2018: Chinese Journal of Integrative Medicine
Gökhan Kaynak, Mehmet Can Ünlü, Mehmet Fatih Güven, Ozan Ali Erdal, Okan Tok, Hüseyin Botanlıoğlu, Önder Aydıngöz
BACKGROUND: Stable fracture fixation is important in the treatment of intertrochanteric femur (ITF) fractures in the elderly population to prevent the loss of reduction, achieve early mobility, and restore independence. The aim of this study was to present the results of surgical treatment of stable and unstable ITF fractures using a trochanteric antegrade intramedullary nail with two cephalocervical screws in an integrated mechanism (Intertan®; Smith & Nephew, Memphis, TN) and evaluate the relationship between the loss of reduction and screw position in the femoral neck in two planes...
May 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
Ersin Kuyucu, Adnan Kara, Ferhat Say, Mehmet Erdil, Murat Bülbül, Barış Gülenç
BACKGROUND: This study aimed to present clinical outcomes in patients with tibial plateau fractures who were treated with hybrid external fixators and describe the details of our technique. Schanz screws were synchronously applied and used as a joystick for fracture reduction. METHODS: The study population included 72 patients with bicondylar tibial plateau fractures classified as type 41-C2 according to the AO classification. Joint reduction was maintained using Schanz screws transmitted through tibial condyles as a joystick under fluoroscopy...
May 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
Kalle Kisand, Ann Tamm, Mare Lintrop, Agu Tamm
OBJECTIVE: This study was conducted to identify cytokine profiles associated with radiographic phenotypes of knee osteoarthritis (rKOA) with a focus on early stage of the disease. METHODS: The pilot population study involved 60 middle-aged patients (mean age 50±7.3y.). Standardized weight-bearing anteroposterior and axial radiographs were used to assess rKOA severity in tibiofemoral (TFJ) of patellofemoral joint (PFJ) by grading system (grades 0-3). Luminex (xMAP® ) technology was used to simultaneously assess 60 biomarkers...
May 18, 2018: Osteoarthritis and Cartilage
Phillip M Mitchell, Adam K Lee, Cory A Collinge, Bruce H Ziran, Kate G Hartley, A Alex Jahangir
OBJECTIVE: To evaluate the early clinical results of distal femur fractures treated with carbon fiber reinforced - polyetheretherketone (CFR-PEEK) plates compared to stainless steel (SS) lateral locking plates. DESIGN: Retrospective comparative cohort study SETTING:: ACS Level I trauma center. PATIENTS/PARTICIPANTS: Twenty-two patients (11 SS, 11 CFR-PEEK) with closed distal femur fractures treated by a single surgeon over a 6-year period...
May 16, 2018: Journal of Orthopaedic Trauma
Hélder Fonte, Ricardo Rodrigues-Pinto
INTRODUCTION: Femoral neck stress fractures are uncommon and depending on their location, can be at high risk for non-union and significant morbidity.  Their prevalence is higher among runners and military recruits, and women seem to be at higher risk. METHODS: A 27-year-old female, who was enrolled in military recruit, reported left side groin pain after a strenuous running exercise. Due to persistent pain an X-Ray was ordered, which revealed no signs of acute lesions...
2018: SICOT-J
K G Pringle, Y Q Lee, L Weatherall, L Keogh, C Diehm, C T Roberts, S Eades, A Brown, R Smith, E R Lumbers, L J Brown, C E Collins, K M Rae
Childhood obesity rates are higher among Indigenous compared with non-Indigenous Australian children. It has been hypothesized that early-life influences beginning with the intrauterine environment predict the development of obesity in the offspring. The aim of this paper was to assess, in 227 mother-child dyads from the Gomeroi gaaynggal cohort, associations between prematurity, Gestation Related-Optimal Weight (GROW) centiles, maternal adiposity (percentage body fat, visceral fat area), maternal non-fasting plasma glucose levels (measured at mean gestational age of 23...
May 16, 2018: Journal of Developmental Origins of Health and Disease
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