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Early Weight bearing

Wataru Miyamoto, Shinji Imade, Ken Innami, Hirotaka Kawano, Masato Takao
BACKGROUND: Although early accelerated rehabilitation is recommended for the treatment of acute Achilles tendon rupture, most traditional rehabilitation techniques require some type of brace. METHODS: We retrospectively analyzed 44 feet of 44 patients (25 male and 19 female) with a mean age of 31.8 years who had an acute Achilles tendon rupture related to athletic activity. Patients had been treated by a double side-locking loop suture (SLLS) technique using double antislip knots between stumps and had undergone early accelerated rehabilitation, including active and passive range of motion exercises on the day following the operation and full weight-bearing at 4 weeks...
October 10, 2016: Foot & Ankle International
Rulin Sun, Santao Zhang, Xing Lu, Wenjun Hu, Ning Lou, Yan Zhao, Jia Zhou, Xiaoping Zhang, Hongmei Yang
Cancer-induced muscle wasting, which commonly occurs in cancer cachexia, is characterized by impaired quality of life and poor patient survival. To identify an appropriate treatment, research on the mechanism underlying muscle wasting is essential. Thus far, studies on muscle wasting using cancer cachectic models have generally focused on early cancer cachexia (ECC), before severe body weight loss occurs. In the present study, we established models of ECC and late cancer cachexia (LCC) and compared different stages of cancer cachexia using two cancer cachectic mouse models induced by colon-26 (C26) adenocarcinoma or Lewis lung carcinoma (LLC)...
October 12, 2016: Oncology Reports
Armaghan Mahmoudian, Jaap H van Dieen, Sjoerd M Bruijn, Isabel Ac Baert, Gert S Faber, Frank P Luyten, Sabine Mp Verschueren
BACKGROUND: Varus thrust, defined as an abrupt increase of the knee varus angle during weight-bearing in gait, has been shown to be present in patients with moderate to severe knee osteoarthritis and is considered to be one of the risk factors for progression of symptomatic medial knee osteoarthritis. We evaluated the presence and magnitude of varus thrust and its relation with the Knee Adduction Moment in women with early medial knee osteoarthritis, and compared it to that in a group of controls and in a group of subjects with established medial knee osteoarthritis...
October 8, 2016: Clinical Biomechanics
F P Campion, F M McGovern, S Lott, A G Fahey, P Creighton, T M Boland
The objectives of this study were 1) to compare the effects of a ME () or a NE () system for rationing ewes during late gestation on ewe and progeny performance and 2) to investigate incremental increases in NE allocation above 100% of recommendation during late gestation on ewe and progeny performance. Fifty-two twin-bearing ewes ( = 13 per treatment) were rationed to either 100% of recommended ME requirements (100% ME) or 100, 110, or 120% of recommended NE requirements (100% NE, 110% NE, and 120% NE) from d 112 of gestation to parturition...
August 2016: Journal of Animal Science
Martin Nilsson, Daniel Sundh, Dan Mellström, Mattias Lorentzon
Physical activity is believed to have the greatest effect on the skeleton if exerted early in life, but whether or not possible benefits of physical activity on bone microstructure or geometry remain at old age has not been investigated in women. The aim of this study was to investigate if physical activity during skeletal growth and young adulthood or at old age was associated with cortical geometry and trabecular microarchitecture in weight-bearing and non-weight bearing bone, and areal bone mineral density (aBMD) in elderly women...
September 27, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Hyun Ho Han, Byung Yeun Kwon, Sung No Jung, Suk-Ho Moon
Occupational injuries to digits due to hydrofluoric acid (HFA) are frequently encountered. They have distinctive features, including intense pain, progressive tissue necrosis, and possible bone erosion. To minimize tissue damage, it is of great importance to execute prudent preoperative assessment and determine the correct surgical modality to reconstruct and maintain the function of the hand. However, proper protocols for fingers have not been presented in previous studies. Eight cases with HFA burn to digits were presented to the emergency room...
September 17, 2016: Burns: Journal of the International Society for Burn Injuries
Mikkel Rathsach Andersen, Nikolaj Winther, Thomas Lind, Henrik SchrøDer, Gunnar Flivik, Michael Mørk Petersen
Background and purpose - Backside wear of the polyethylene insert in total knee arthroplasty (TKA) can produce clinically significant levels of polyethylene debris, which can lead to loosening of the tibial component. Loosening due to polyethylene debris could theoretically be reduced in tibial components of monoblock polyethylene design, as there is no backside wear. We investigated the effect of 2 different tibial component designs, monoblock and modular polyethylene, on migration of the tibial component in uncemented TKA...
September 20, 2016: Acta Orthopaedica
Jay R Ebert, Peter K Edwards, Daniel P Fick, Gregory C Janes
CONTEXT: Gluteus medius rehabilitation is of critical importance given its role in pelvic and lower limb stability, and the known link between gluteus medius weakness and many lower limb conditions. OBJECTIVE: To systematically review the literature and present an evidence-based graduated series of exercises to progressively load gluteus medius. EVIDENCE ACQUISITION: A systematic literature search was conducted in January 2016 to identify studies reporting gluteus medius muscle activity as a percentage of maximal volitional isometric contraction (%MVIC), during rehabilitation exercises...
August 24, 2016: Journal of Sport Rehabilitation
Mahantesh Yellangouda Patil, Srinath Myadam Gupta, Sri Krishna Chaitanya Kurupati, Saumya Agarwal, Vishal Chandarana
INTRODUCTION: Open fractures are treated as surgical emergency and early administration of intravenous antibiotic coupled with early irrigation and debridement decreases the infection rate dramatically. Limb Reconstruction System (LRS) is a unilateral rail system which consists of Shanz pins, rail rods and sliding clamps. It is specifically designed to enable the surgeon to perform simple and effective surgery as it offers rigid fixation of fracture fragments, allowing early weight bearing and reduces economic burden...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
Zhenzhen Wei, Yafeng Wu, Yuewu Zhao, Li Mi, Jintao Wang, Jimin Wang, Jinjin Zhao, Lixin Wang, Anran Liu, Ying Li, Wei Wei, Yuanjian Zhang, Songqin Liu
Multifunctional nanoprobes with distinctive magnetic and fluorescent properties are highly useful in accurate and early cancer diagnosis. In this study, nanoparticles of Fe3O4 core with fluorescent SiO2 shell (MFS) are synthesized by a facile improved Stöber method. These nanoparticles owning a significant core-shell structure exhibit good dispersion, stable fluorescence, low cytotoxicity and excellent biocompatibility. TLS11a aptamer (Apt1), a specific membrane protein for human liver cancer cells which could be internalized into cells, is conjugated to the MFS nanoparticles through the formation of amide bond working as a target-specific moiety...
September 28, 2016: Analytica Chimica Acta
Peter D Gibson, Joseph A Ippolito, Joseph Benevenia
Improvements in imaging and treatment of musculoskeletal tumors have increased the variety of options for reconstruction following joint-sparing diaphyseal resection. The purpose of this case series was to show that reconstruction of malignant tumors of the radial shaft with an intercalary prosthesis may be an option for patients with segmental bone loss. Three consecutive patients underwent wide resection of the radial diaphysis followed by reconstruction with a custom intercalary prosthesis. A custom intercalary prosthesis with lap joint design was used in all 3 cases...
September 8, 2016: Orthopedics
Nicholas P Ryan, Miriam H Beauchamp, Richard Beare, Lee Coleman, Michael Ditchfield, Michael Kean, Timothy J Silk, Sila Genc, Cathy Catroppa, Vicki A Anderson
Cognitive fatigue is among the most profound and disabling sequelae of pediatric acquired brain disorders, however the neural correlates of these symptoms in children remains unexplored. One hypothesis suggests that cognitive fatigue may arise from dysfunction of cortico-striatal networks (CSNs) implicated in effort output and outcome valuation. Using pediatric traumatic brain injury (TBI) as a model, this study investigated (i) the sub-acute effect of brain injury on CSN volume; and (ii) potential relationships between cognitive fatigue and sub-acute volumetric abnormalities of the CSN...
October 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Isao Matsushita, Hiraku Motomura, Eiko Seki, Tomoatsu Kimura
OBJECTIVES: The long-term effects of tumour necrosis factor (TNF)-blocking therapies on weight-bearing joints in patients with rheumatoid arthritis (RA) have not been fully characterized. The purpose of this study was to assess the radiographic changes of weight-bearing joints in patients with RA during 3-year of TNF-blocking therapies and to identify factors related to the progression of joint damage. METHODS: Changes in clinical variables and radiological findings in 243 weight-bearing joints (63 hips, 54 knees, 71 ankles and 55 subtalar joints) in 38 consecutive patients were investigated during 3 years of treatment with TNF-blocking agents...
September 2, 2016: Modern Rheumatology
Zhiwei Zhang, Hua Sun, Jianhua Zhang, Chunlei Ge, Suwei Dong, Zhen Li, Ruilei Li, Xiaodan Chen, Mei Li, Yun Chen, Yingying Zou, Zhongyi Qian, Lei Yang, Jinyan Yang, Zhitao Zhu, Zhimin Liu, Xin Song
BACKGROUND Transplantation with allogeneic cells has become a promising modality for cancer therapy, which can induce graft-versus-tumor (GVT) effect. This study was aimed at assessing the safety, efficacy, and tissue type GVT (tGVT) response of transplantation with allogeneic skin tumors to treat chemically-induced skin tumors in mice. MATERIAL AND METHODS FVB/N and ICR mice were exposed topically to chemicals to induce skin tumors. Healthy ICR mice were transplanted with allogeneic skin tumors from FVB/N mice to test the safety...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
James Melrose
The intervertebral disc (IVD) is a major weight bearing structure that undergoes degenerative changes with aging limiting its ability to dissipate axial spinal loading in an efficient manner resulting in the generation of low back pain. Low back pain is a number one global musculoskeletal disorder with massive socioeconomic impact. The WHO has nominated development of mesenchymal stem cells and bioscaffolds to promote IVD repair as primary research objectives. There is a clear imperative for the development of strategies to effectively treat IVD defects...
October 2016: Regenerative Medicine
Raju Vaishya, Amit Kumar Agarwal, Nishint Gupta, Vipul Vijay
Avascular necrosis (AVN) of femoral head needs to be addressed early in the course of the disease, to prevent progression to osteoarthritis. A revascularizing procedure which can help preserve the head should be considered in young adults to alleviate the need for total hip arthroplasty. We included 40 cases (53 hips) of AVN of femoral head operated with Sartorius muscle pedicle iliac bone grafting, done by the senior author. Early post-operative rehabilitation was done. The weight bearing was delayed for 6 weeks...
August 2016: Journal of Hip Preservation Surgery
N Borisch
BACKGROUND: Operative treatment of chondrocalcinosis (calcium pyrophosphate dihydrate deposition disease=CPPD disease) of the wrist is hardly ever mentioned in the literature. Since the chronic, recurrent type of this disease resembles rheumatoid arthritis (RA) as well as osteoarthritis, the author has performed arthroscopic synovectomy of the wrist, which achieves excellent results in RA und offers high patient comfort as an atraumatic procedure with low morbidity. This article presents the experience made with arthroscopic synovectomy in CPPD disease of the wrist...
August 2016: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
Fekede Asefa, Dereje Nemomsa
BACKGROUND: Gestational weight gain is an important factor that supports optimal outcome for mothers and their infant. Whereas women who do not gain enough weight during pregnancy have a risk of bearing a baby with low birth weight, those who gain excessive weight are at increased risk of preeclampsia and gestational diabetes. Nonetheless, data on gestational weight gain and its determinants are scarce in developing countries, as it is difficult to collect the information throughout the pregnancy period...
2016: Reproductive Health
Colin Russell, Valentina Pedoia, Sharmila Majumdar
This study looked to investigate a new quantitative metric, R2  - R1ρ (1/T2  - 1/T1ρ ), using magnetic resonance (MR) images and voxel-based relaxometry (VBR) for detecting early cartilage degeneration and explore the association with patient-reported outcomes measures (PROMs) in patients 6 months after ACL reconstruction. Sixty-four patients from three sites were bilaterally scanned on a 3T MR with a combined T1ρ /T2 protocol to calculate R1ρ (1/T1ρ ) and R2 (1/T2 ) values at baseline and 6 months after reconstructive surgery...
August 26, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Scott B Shawen, Theodora Dworak, Robert B Anderson
Ankle sprains are the most common musculoskeletal injury occurring during athletics. Proper initial treatment with supportive pain control, limited immobilization, early return to weight bearing and range of motion, and directed physical therapy are essential for preventing recurrent injury. Reconstruction of the lateral ligaments is indicated for patients with continued instability and dysfunction despite physical therapy. Return to athletic activity should be reserved for athletes who have regained strength, proprioception, and range of motion of the injured ankle...
October 2016: Clinics in Sports Medicine
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