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https://www.readbyqxmd.com/read/29449014/periarticular-bone-predicts-knee-osteoarthritis-progression-data-from-the-osteoarthritis-initiative
#1
Grace H Lo, Erika Schneider, Jeffrey B Driban, Lori Lyn Price, David J Hunter, Charles B Eaton, Marc C Hochberg, Rebecca D Jackson, C Kent Kwoh, Michael C Nevitt, John A Lynch, Timothy E McAlindon
OBJECTIVE: Osteoarthritis (OA) is a disease with a substantial public health burden. Quantitative assessments of periarticular bone may be a biomarker capable of monitoring early disease progression. The purpose of this study was to evaluate whether measures of periarticular bone associate with longitudinal structural progression. METHODS: We conducted a 12-18 months longitudinal study using the Osteoarthritis Initiative (OAI). Participants received knee dual-energy x-ray absorptiometry (DXA), trabecular magnetic resonance (MR) imaging, and x-rays...
January 31, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29444576/-fractures-of-the-fifth-metatarsal-base
#2
K Bušková, D Kuběnová, M Tuček
Fractures of the fifth metatarsal base are among the most common fractures of the foot. They are typically caused by indirect violence during sports activities. This region is also a site where stress fractures occur frequently. Diagnosis is based on the patients medical history, clinical examination and imaging methods. The fundamental imaging method is radiography of the foot in three views. MRI is used primarily for early diagnosis of stress fractures. CT examination is beneficial mainly in complex foot injuries, in order to rule out associated fractures...
2018: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/29429485/paradigm-shifts-in-understanding-equine-laminitis
#3
REVIEW
J C Patterson-Kane, N P Karikoski, C M McGowan
Laminitis, one of the most debilitating conditions of all equids, is now known to be the result of several systemic disease entities. This finding, together with other recent developments in the field of laminitis research, have provoked a rethink of our clinical and research strategies for this condition. First, laminitis is now considered to be a clinical syndrome associated with systemic disease (endocrine disease, sepsis or systemic inflammatory response syndrome, SIRS) or altered weight bearing rather than being a discrete disease entity...
January 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29424146/-comparison-of-pfna-and-intertan-intramedullary-nail-in-treating-unstable-femoral-intertrochanteric-fractures
#4
Jun Zhang, Lie-Hu Cao, Xiao Chen, Jia-Can Su
OBJECTIVE: To compare the clinical effects of PFNA and InterTAN for the treatment of unstable intertrochanteric fractures in the elderly patients. METHODS: From April 2012 to February 2014, 113 elderly patients with unstable intertrochanteric fractures were treated by PFNA or InterTAN. There were 64 cases in PFNA group, including 25 males and 39 females with an average age of (73.3±6.5) years old (ranged, 66 to 85);while 49 cases in InterTAN group, including 20 males and 29 females with an average age of (74...
July 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29413802/real-time-visual-biofeedback-to-improve-therapy-compliance-after-total-hip-arthroplasty-a-pilot-randomized-controlled-trial
#5
Marco Raaben, H Charles Vogely, Taco J Blokhuis
BACKGROUND: Previous studies have shown limited therapy compliance in weight-bearing in patients following total hip arthroplasty. RESEARCH QUESTION: The purpose of this pilot RCT is to determine the immediate and late effect of real-time, visual biofeedback on weight-bearing during rehabilitation after THA in elderly. METHODS: 24 participants who underwent THA were randomized to either the control or the intervention group. The intervention group received real-time, visual biofeedback on weight-bearing during training with the physical therapist during hospitalization and at twelve weeks follow up...
January 31, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29413767/the-role-of-intramedullary-fixation-in-ankle-fractures-a-systematic-review
#6
REVIEW
R W Jordan, A W P Chapman, D Buchanan, P Makrides
BACKGROUND: Ankle fractures are one of the most commonly occurring fractures in the elderly population. The overall incidence has been reported to be up to 184 fractures per 100,000 persons per year, of which 20-30% occur in the elderly. Medical co-morbidities, osteoporosis, suboptimal skin quality and poor toleration of non-weight bearing status all contribute to difficulties in managing these injuries in this population. Intramedullary implants are advantageous as they utilise smaller incisions, minimise soft tissue disruption and may allow early weight bearing...
February 2018: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29397414/the-antegrade-angle-stable-locking-intramedullary-nail-for-type-c-distal-femoral-fractures-a-thirty-four%C3%A2-case-experience
#7
Zhihui Zhao, Yi Li, Kifayat Ullah, Basanta Sapkota, Hongbin Bi, Yongqing Wang
INTRODUCTION: This is a retrospective study that provides initial experience and verifies the effectiveness of the newly-designed antegrade interlocking angle-stable intramedullary nail (IAIN) combined with half-threaded cancellous screws in the management of type-C (AO/OTA classification) distal femoral fractures. METHODS: During a period of 30 months, 34 patients (mean age 43.1 years) with type-C (AO/OTA classification) fractures of the distal femur were treated with IAIN and half-threaded cancellous screws were reviewed...
February 3, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29392383/intramedullary-nailing-in-opening-wedge-high-tibial-osteotomy-in-vitro-test-for-validation-of-a-method-of-fixation
#8
Rene Burchard, Denise Katerla, Marina Hammer, Anke Pahlkötter, Christian Soost, Gerhard Dietrich, Arne Ohrndorf, Wolfgang Richter, Markus Lengsfeld, Hans-Jürgen Christ, Jan Adriaan Graw, Claus-Peter Fritzen
PURPOSE: Opening wedge high tibial osteotomy (HTO) as a treatment in unicompartimental osteoarthritis of the knee can significantly relieve pain and prevent or at least delay an early joint replacement. The fixation of the osteotomy has undergone development and refinements during the last years. The angle-stable plate fixator is currently one of the most commonly used plates in HTOs. The angular stable fixation between screws and the plate offers a high primary stability to retain the correction with early weight-bearing protocols...
February 1, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29391063/permissive-weight-bearing-in-trauma-patients-with-fracture-of-the-lower-extremities-prospective-multicenter-comparative-cohort-study
#9
Pishtiwan H S Kalmet, Guido Meys, Yvette Y V Horn, Silvia M A A Evers, Henk A M Seelen, Paul Hustinx, Heinrich Janzing, Alexander Vd Veen, Coen Jaspars, Jan Bernard Sintenie, Taco J Blokhuis, Martijn Poeze, Peter R G Brink
BACKGROUND: The standard aftercare treatment in surgically treated trauma patients with fractures around or in a joint, known as (peri)- or intra-articular fractures of the lower extremities, is either non-weight bearing or partial weight bearing. We have developed an early permissive weight bearing post-surgery rehabilitation protocol in surgically treated patients with fractures of the lower extremities. In this proposal we want to compare our early permissive weight bearing protocol to the existing current non-weight bearing guidelines in a prospective comparative cohort study...
February 2, 2018: BMC Surgery
https://www.readbyqxmd.com/read/29387648/early-radiographic-and-clinical-outcomes-of-minimally-displaced-proximal-fifth-metatarsal-fractures-cast-vs-functional-bandage
#10
Carlo Biz, Marco Zamperetti, Alberto Gasparella, Miki Dalmau-Pastor, Marco Corradin, Giacomo de Guttry, Pietro Ruggieri
Background: The purpose of this non-randomized retrospective study was to investigate outcomes of minimally displaced, proximal 5MTB fractures, treated by a below-knee walking cast or a functional elasticated bandage with a support of a flat hard-soled shoe. Methods: A consecutive patient series was divided into two groups: the cast group (CG) and the functional group (FG). The subjects were radiologically and clinically evaluated according to Mehlhorn and Lawrence-Botte classification, and AOFAS Midfoot score, respectively...
July 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/29377654/peptide-mediated-targeting-mesoporous-silica-nanoparticles-a-novel-tool-for-fighting-bladder-cancer
#11
Sean K Sweeney, Yi Luo, Michael A O'Donnell, Jose G Assouline
Transitional cell carcinoma of the bladder is particularly devastating due to its high rate of recurrence and difficulty in retention of treatments within the bladder. Current cystoscopic approaches to detect and stage the tumor are limited by the penetrative depth of the cystoscope light source, and intravesical dyes that highlight tumors for surgical resection are non-specific. To address the needs for improved specificity in tumor detection and follow-up, we report on a novel technology relying on the engineered core of mesoporous silica (MSN) with surface modifications that generate contrast in fluorescence and magnetic resonance imaging (MRI)...
February 2017: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29357023/early-prediction-of-triple-negative-breast-cancer-response-to-cisplatin-treatment-using-diffusion-weighted-mri-and-18f-fdg-pet
#12
Huong Nguyen-Thu, Hirofumi Hanaoka, Takahito Nakajima, Aiko Yamaguchi, Tien Nguyen-Cong, A Adhipatria P Kartamihardja, Yoshito Tsushima
BACKGROUND: We evaluated the potential of diffusion-weighted MRI (DW-MRI) and 18F-FDG-PET for the early prediction of a triple negative breast cancer (TNBC) response to cisplatin. METHODS: Cisplatin-treated TNBC tumor-bearing mice were categorized as responders or non-responders based on the tumor growth rate. DW-MRI and 18F-FDG-PET were performed before and after treatment (day 0 and days 3 and 7, respectively). The average apparent diffusion coefficient value (ADCmean), the highest standardized uptake value (SUVmax), and the metabolic tumor volume (MTV) were measured...
January 22, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29354441/arthroscopic-excision-of-an-osteoid-osteoma-of-the-lesser-trochanter-of-the-femoral-neck
#13
Byung-Ho Yoon, Jung Gon Kim, Yong-Chan Ha
Osteoid osteoma frequently requires surgical treatment, especially among young, active patients. However, surgeons are reluctant to perform open surgery for an osteoid osteoma of the femoral neck area because the conventional surgical approach requires a large incision in muscular patients, and percutaneous resection with a trephine has the attendant risk of subsequent fracture. Recently, arthroscopic excision of an osteoid osteoma has been reported as a less invasive, safer procedure than traditional open curettage...
August 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29349973/-progress-on-surgical-treatment-for-femoral-head-preservering-in-the-precollapse-stage-of-femoral-head-necrosis
#14
REVIEW
Yi-Heng Ye, Kai Chen, Ke-Ke Jin, Yi-Fan Zhang, Lei Chen
Osteonecrosis of the femoral head(ONFH), a refractory disease characterized by death of the osteocytes and the bone marrow due to inadequate blood supply caused by various mechanisms, usually leads to the collapse of the femoral head and malfunction of the hip joint. The crux is to diagnose ONFH early in the precollapse stage and prevent subsequent progression of collapsing through early interventions, thus delaying or avoiding the replacement of the hip joint. A number of joint salvaging operation treatments for early stage ONFH are available...
March 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349033/arthroscopic-reduction-and-fixation-of-tibial-spine-avulsion-fractures-by-a-stainless-steel-wiring-technique
#15
Mohamed M Abdelhamid, Maysara Abdelhalim Bayoumy, Hesham A Elkady, Ayman Farouk Abdelkawi
Several techniques of arthroscopic treatment of tibial spine avulsion fractures have been described in the literature. These techniques include the use of various fixation devices such as screws, K-wires, wiring, sutures, and suture anchors. In this study, we evaluate a new wiring technique for the treatment of these injuries. This technique involves fixation by stainless steel tension wires passed over the fractured spine and tied over a bone bridge. The advantages of this technique are that it aids in reduction, allows for compression of the tibial spine fragment anatomically in its fracture bed, provides stable fixation in difficult comminuted fractures, and allows for early mobilization and weight bearing because of the solid fixation...
December 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29337456/-pediatrics-perthes-disease-current-knowledges-and-treatment
#16
Sophie Merckaert, Pierre-Yves Zambelli
Perthes's disease corresponds to an interruption of the vascularization of the epiphyseal nucleus of the femoral head followed by avascular necrosis. This necrosis weakens the bone and subchondral fractures associated with a deformation of the femoral head is seen. It is important not to miss an extrusion of the femoral head, which makes surgical treatment unavoidable. The loss of joint congruence causes functional limitations and represents an increased risk for early hip osteoarthritis. Non weight bearing limits the subchondral fractures, but requires an important adaptation from the patient and his entourage...
January 10, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29327428/an-endochondral-ossification-approach-to-early-stage-bone-repair-use-of-tissue-engineered-hypertrophic-cartilage-constructs-as-primordial-templates-for-weight-bearing-bone-repair
#17
Amos Matsiko, Emmet M Thompson, Cai Lloyd-Griffith, Gráinne M Cunniffe, Tatiana Vinardell, John P Gleeson, Daniel J Kelly, Fergal J O'Brien
Mimicking endochondral ossification to engineer constructs offers a novel solution to overcoming the problems associated with poor vascularisation in bone repair. This can be achieved by harnessing the angiogenic potency of hypertrophic cartilage. In this study, we demonstrate that tissue-engineered hypertrophically-primed cartilage constructs can be developed from collagen-based scaffolds cultured with mesenchymal stem cells. These constructs were subsequently implanted into femoral defects in rats. It was evident that the constructs could support enhanced early-stage healing at 4 weeks of these weight-bearing femoral bone defects compared to untreated defects...
January 11, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29322877/topographical-variation-of-human-femoral-articular-cartilage-thickness-t1rho-and-t2-relaxation-times-is-related-to-local-loading-during-walking
#18
Sam Van Rossom, Mariska Wesseling, Dieter Van Assche, Ilse Jonkers
Objective Early detection of degenerative changes in the cartilage matrix composition is essential for evaluating early interventions that slow down osteoarthritis (OA) initiation. T1rho and T2 relaxation times were found to be effective for detecting early changes in proteoglycan and collagen content. To use these magnetic resonance imaging (MRI) methods, it is important to document the topographical variation in cartilage thickness, T1rho and T2 relaxation times in a healthy population. As OA is partially mechanically driven, the relation between these MRI-based parameters and localized mechanical loading during walking was investigated...
January 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29317315/carry-over-effects-modulated-by-salinity-during-the-early-ontogeny-of-the-euryhaline-crab-hemigrapsus-crenulatus-from-the-southeastern-pacific-coast-development-time-and-carbon-and-energy-content-of-offspring
#19
Ángel Urzúa, Miguel Bascur, Fabián Guzmán, Mauricio Urbina
Hemigrapsus crenulatus is a key species of coastal and estuarine ecosystems in the Southeastern Pacific and New Zealand. Since the gravid females-and their embryos-develop under conditions of variable salinity, we propose that low external salinity will be met with an increase in energy expenditures in order to maintain osmoregulation; subsequently, the use of energy reserves for reproduction will be affected. In this study, we investigate in H. crenulatus whether 1) the biomass and energy content of embryos is influenced by salinity experienced during oogenesis and embryogenesis and 2) how variation in the biomass and energy content of embryos affects larval energetic condition at hatching...
January 6, 2018: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/29313071/glucocorticoids-inflammation-and-bone
#20
REVIEW
Melek Güler-Yüksel, Jos N Hoes, Irene E M Bultink, Willem F Lems
The current review on glucocorticoids (GCs), inflammation and bone is focused on three aspects: (1) the mutual effects between GCs, inflammation and bone in inflammatory rheumatic diseases, (2) current views on fracture risk assessment in patients using GCs and (3) non-pharmacological and pharmacological treatment to prevent fractures in GC-using patients with inflammatory rheumatic diseases. The use of GCs results in increased risk for fractures due to both direct and indirect negative effects of GCs on bone mass, and on bone and muscle strength...
January 8, 2018: Calcified Tissue International
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