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https://www.readbyqxmd.com/read/29038897/-acute-achilles-tendon-rupture-state-of-the-art
#1
REVIEW
M Braunstein, S F Baumbach, V Herterich, W Böcker, H Polzer
The most favorable treatment for acute Achilles tendon ruptures remains controversial. In particular, three key questions are intensively debated: is operative or non-operative treatment superior? If surgery is performed, should open or minimally invasive percutaneous techniques be used? How should the follow-up treatment be carried out? The aim of this article is to answer these essential questions based on the currently available evidence. Non-operative treatment leads to a higher rate of re-ruptures and inferior functional results when compared to operative treatment...
October 16, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/29033844/syngeneic-b16f10-melanoma-causes-cachexia-and-impaired-skeletal-muscle-strength-and-locomotor-activity-in-mice
#2
Fabrício A Voltarelli, Fernando T Frajacomo, Camila de Souza Padilha, Mayra T J Testa, Paola S Cella, Diogo F Ribeiro, Donizete X de Oliveira, Luciana C Veronez, Gabriela S Bisson, Felipe A Moura, Rafael Deminice
Muscle wasting has been emerging as one of the principal components of cancer cachexia, leading to progressive impairment of work capacity. Despite early stages melanomas rarely promotes weight loss, the appearance of metastatic and/or solid tumor melanoma can leads to cachexia development. Here, we investigated the B16F10 tumor-induced cachexia and its contribution to muscle strength and locomotor-like activity impairment. C57BL/6 mice were subcutaneously injected with 5 × 10(4) B16F10 melanoma cells or PBS as a Sham negative control...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29031985/spatial-angular-compounding-technique-for-h-scan-ultrasound-imaging
#3
Mawia Khairalseed, Fangyuan Xiong, Jung-Whan Kim, Robert F Mattrey, Kevin J Parker, Kenneth Hoyt
H-Scan is a new ultrasound imaging technique that relies on matching a model of pulse-echo formation to the mathematics of a class of Gaussian-weighted Hermite polynomials. This technique may be beneficial in the measurement of relative scatterer sizes and in cancer therapy, particularly for early response to drug treatment. Because current H-scan techniques use focused ultrasound data acquisitions, spatial resolution degrades away from the focal region and inherently affects relative scatterer size estimation...
October 11, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29022056/implant-strategy-affects-scaffold-stability-and-integrity-in-cartilage-treatment
#4
M Drobnic, Francesco Perdisa, E Kon, F Cefalì, M Marcacci, G Filardo
PURPOSE: To identify the most appropriate implantation strategy for a novel chondral scaffold in a model simulating the early post-operative phase, in order to optimize the implant procedure and reduce the risk of early failure. METHODS: Eight human cadaveric limbs were strapped to a continuous passive motion device and exposed to extension-flexion cycles (0°-90°). Chondral lesions (1.8 cm diameter) were prepared on condyles, patella and trochlea for the implant of a bi-layer collagen-hydroxyapatite scaffold...
October 11, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29019890/external-fixation-combined-with-delayed-internal-fixation-in-treatment-of-tibial-plateau-fractures-with-dislocation
#5
Xingguang Tao, Nong Chen, Fugen Pan, Biao Cheng
The aim of this study was to evaluate the clinical efficacy of external fixation, delayed open reduction, and internal fixation in treating tibial plateau fracture with dislocation.Clinical data of 34 patients diagnosed with tibial plateau fracture complicated with dislocation between January 2009 and May 2015 were retrospectively analyzed. Fifteen patients in group A underwent early calcaneus traction combined with open reduction and internal fixation and 19 in group B received early external fixation combined with delayed open reduction and internal fixation...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28975378/percutaneous-ultrasound-guided-cryoablation-for-symptomatic-plantar-fibromas
#6
Muneeb Ahmed, Jeffrey L Weinstein, Jawad Hussain, Ammar Sarwar, Megan Anderson, Brian Dillon
PURPOSE: Here, we report our experience in treating painful plantar fibromas with percutaneous cryoablation. METHODS: We retrospectively identified patients with symptomatic plantar fibromas who underwent percutaneous ultrasound-guided cryoablation between June 2014 and June 2015. In total, four patients (two male, two female) with five plantar fibromas undergoing a total of seven ablation procedures were identified. Each procedure was performed under general anesthesia using a single freeze-thaw cycle...
October 3, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28973413/aryl-hydrocarbon-receptor-ablation-in-cardiomyocytes-protects-male-mice-from-heart-dysfunction-induced-by-nkx2-5-haploinsufficiency
#7
Qin Wang, Yunxia Fan, Hisaka Kurita, Min Jiang, Sheryl Koch, Marepalli B Rao, Jack Rubinstein, Alvaro Puga
Epidemiological studies in humans and research in vertebrates indicates that developmental exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a ubiquitous and biopersistent environmental toxicant, is associated with incidence of early congenital heart disease in the embryo and later in the adult. TCDD-mediated toxicity depends on the aryl hydrocarbon receptor (AHR) but the role of the TCDD-activated AHR in cardiac function is not well defined. To characterize the mechanisms responsible for AHR-mediated disruption of heart function, we generated several mouse strains with cardiomyocyte-specific Ahr gene knockout...
August 14, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28969946/venous-thromboembolism-events-after-hip-arthroscopy-a-systematic-review
#8
REVIEW
Chloe E Haldane, Seper Ekhtiari, Darren de Sa, Nicole Simunovic, Marc Safran, Filippo Randelli, Andrew Duong, Forough Farrokhyar, Olufemi R Ayeni
PURPOSE: The purpose of this systematic literature review focused on hip arthroscopy was to (1) report the venous thromboembolism (VTE) event incidence in patients who receive VTE prophylaxis and those who do not, (2) report how VTE prophylaxis is currently being administered, and (3) report operative and patient-related risk factors for VTE identified in the literature. METHODS: The electronic databases MEDLINE, Embase, and PubMed were searched from database inception to October 10, 2016, and screened in duplicate for relevant studies...
September 29, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28969222/closed-external-fixation-for-failing-or-failed-femoral-shaft-plating-in-a-developing-country
#9
Adil Aliakbar, Ibrahim Witwit, Alaa A Hussein Al-Algawy
INTRODUCTION: Femoral shaft fractures are one of the common injuries that is treated by open reduction, with internal fixation by plate and screws or intramedullary nailing, which can achieve a high union rate. AIM: To evaluate the outcome of using closed external fixation to augment a failing plate; with signs of screw loosening and increasing bone/plate gap; a failed plate; broken plate; screws completely out of bone with redisplacement of fracture. MATERIALS AND METHODS: A retrospective study on 18 patients, aged between 17-42 years, who presented between 6-18 weeks after initial surgical fixation, with pain, difficulty in limb function, deformity and abnormal movement at fracture site, was done...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28966378/patella-height-changes-post-high-tibial-osteotomy
#10
Siew Ghim Gooi, Chloe Xiao Yun Chan, Melvin Kian Loong Tan, Andrew Kean Seng Lim, Kandiah Satkunanantham, James Hoi Po Hui
BACKGROUND: Medial opening wedge high tibial osteotomy (HTO) is a well-described treatment in early medial compartmental osteoarthritis of the knee. However, two undesirable sequelae may follow -patella baja and changes in the posterior tibial slope (TS). MATERIALS AND METHODS: We conducted a retrospective study in patients who underwent HTO in our center between September 2009 and February 2017. Preoperative and 6-week postoperative long-leg weight bearing films and lateral knee radiographs were assessed...
September 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28956152/which-factors-are-independent-predictors-of-early-recovery-of-mobility-in-the-older-adults-population-after-hip-fracture-a-cohort-prognostic-study
#11
Mattia Morri, Cristiana Forni, Maura Marchioni, Elena Bonetti, Francesca Marseglia, Andrea Cotti
INTRODUCTION: The aim of the present study was to identify all factors that might influence the short-term recovery of mobility in older adults' patients after hip surgery. METHODS: A prospective cohort prognostic study was carried out. The study enrolled all consecutive patients aged 65 years or over admitted for hip fracture due to fragility. Patients were monitored from their admission into the emergency department of the hospital, until their discharge. The level of mobility was measured by the ILOA scale, administered during the 6th day of hospitalisation...
September 27, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28952794/management-of-a-tibial-plafond-lung-cancer-metastasis-using-an-intramedullary-hindfoot-fusion-nail
#12
Andrew R Hsu, Adam D Lindsay
Metastatic disease to the tibial plafond is rare with few reports in the literature. No consensus exists regarding surgical reconstruction of large structural defects of the ankle due to these lesions, as each treatment must be tailored to the individual patient's goals and prognosis. Cancer metastases pose a unique challenge to limb salvage as there is often bone loss and poor soft tissue quality combined with the need for postoperative adjuvant therapy. The goal of surgery is to obtain early weightbearing, pain relief, and a durable reconstruction that will outlive the patient...
September 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28900738/novel-temporary-left-ventricular-assist-system-with-hydrodynamically-levitated-bearing-pump-for-bridge-to-decision-initial-preclinical-assessment-in-a-goat-model
#13
Satoru Kishimoto, Yoshiaki Takewa, Tomonori Tsukiya, Toshihide Mizuno, Kazuma Date, Hirohito Sumikura, Yutaka Fujii, Kentaro Ohnuma, Konomi Togo, Nobumasa Katagiri, Noritsugu Naito, Yuichiro Kishimoto, Yoshinobu Nakamura, Motonobu Nishimura, Eisuke Tatsumi
The management of heart failure patients presenting in a moribund state remains challenging, despite significant advances in the field of ventricular assist systems. Bridge to decision involves using temporary devices to stabilize the hemodynamic state of such patients while further assessment is performed and a decision can be made regarding patient management. We developed a new temporary left ventricular assist system employing a disposable centrifugal pump with a hydrodynamically levitated bearing. We used three adult goats (body weight, 58-68 kg) to investigate the 30-day performance and hemocompatibility of the newly developed left ventricular assist system, which included the pump, inflow and outflow cannulas, the extracorporeal circuit, and connectors...
September 12, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28894378/initial-experience-of-correlating-diffusion-spectral-parameters-with-histopathologic-indexes-in-murine-colorectal-tumor-homografts
#14
Xiao-Yan Zhang, Xiao-Ting Li, Jia Sun, Ying-Shi Sun
PURPOSE: To determine the correlation between continuously distributed diffusion-weighted image (DWI)-derived parameters and histopathologic indexes. METHODS: Fifty-four mice bearing HCT-116 colorectal tumors were included for analysis; 12 mice were used for continuous observation, and the other 42 mice were used for break-point observation. All mice were randomly divided into radiotherapy and non-radiotherapy groups. Optical imaging and MRI were performed at different time points according to radiotherapy regimen (baseline, 24 h, 48 h, 72 h, 7 d, 14 d, and 28 d)...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28885454/attenuation-of-early-phase-inflammation-by-cannabidiol-prevents-pain-and-nerve-damage-in-rat-osteoarthritis
#15
Holly T Philpott, Melissa OʼBrien, Jason J McDougall
Osteoarthritis (OA) is a multifactorial joint disease, which includes joint degeneration, intermittent inflammation, and peripheral neuropathy. Cannabidiol (CBD) is a noneuphoria producing constituent of cannabis that has the potential to relieve pain. The aim of this study was to determine whether CBD is anti-nociceptive in OA, and whether inhibition of inflammation by CBD could prevent the development of OA pain and joint neuropathy. Osteoarthritis was induced in male Wistar rats (150-175 g) by intra-articular injection of sodium monoiodoacetate (MIA; 3 mg)...
September 27, 2017: Pain
https://www.readbyqxmd.com/read/28869634/the-effects-of-an-early-intrahospital-rehabilitation-on-weight-bearing-during-lower-extremity-lengthening-with-ilizarov-method
#16
Grzegorz Konieczny, Piotr Morasiewicz, Natalia Kuciel
PURPOSE: Exerting axial pressure on the affected lower limb remains one of the most crucial elements of Ilizarov method. The objective was to determine the effects of an early intrahospital rehabilitation on weight bearing during lower extremity lengthening with Ilizarov method. METHODS: The study included 15 patients who underwent lower limb lengthening. The patients were tested on the third day after surgery using the pedobarographic platform. The tests were performed four times in the standing position: twice with the support of forearm crutches and twice without crutches...
2017: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/28856344/bone-stress-injuries-in-the-military-diagnosis-management-and-prevention
#17
Steven F DeFroda, Kenneth L Cameron, Matthew Posner, Peter K Kriz, Brett D Owens
Bone stress injuries occur when forces applied to a bone for an extended period exceed the ability of the bone to adequately remodel. These injuries, which range from stress reactions to nondisplaced and even displaced fractures, most often affect people who experience high levels of repetitive stress and loading in the lower extremity or changes in physical activity level. For example, stress fractures are common in endurance athletes, in athletes engaged in preseason and early-season conditioning, and in military recruits...
July 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/28853599/pyomyositis-of-the-pectineus-muscle-in-an-adolescent-male
#18
J Hiddema, S Hassan, N Mangat, N Siddiqui
The 'irritable hip' continues to pose a challenge for clinicians. Even with predictive clinical algorithms, decision making can be difficult. Emergency treatment is required if septic arthritis is suspected. Other differential diagnoses such as transient synovitis, pyomyositis of the pelvic girdle muscles and osteomyelitis must be considered in order to help guide appropriate investigations and allow early treatment. We report the case of a 13-year-old boy presenting to our institution with an acutely painful left hip but still able to weight bear...
September 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28842287/determining-potential-of-pmma-as-a-depot-for-rifampin-to-treat-recalcitrant-orthopaedic-infections
#19
Stefanie M Shiels, David J Tennent, Kevin S Akers, Joseph C Wenke
BACKGROUND: Open fractures are often complicated by infection. In cases of severe soft tissue and vascular injury, systemic antibiotics may be ineffective due to their inability to reach and provide direct antimicrobial activity to the zone of injury. High antibiotic concentrations within the wound can be achieved with reduced systemic toxicity by using local antibiotic delivery. As bacteria associated with musculoskeletal injuries frequently form biofilms, antibiotic selection is important...
August 16, 2017: Injury
https://www.readbyqxmd.com/read/28833914/patellofemoral-and-tibiofemoral-alignment-in-a-fully-weight-bearing-upright-mr-implementation-and-repeatability
#20
Erin M Macri, Kay M Crossley, Agnes G d'Entremont, Harvi F Hart, Bruce B Forster, David R Wilson, Charles R Ratzlaff, Anne M Walsh, Karim M Khan
PURPOSE: To develop methods for evaluating 3D patellofemoral and tibiofemoral alignment in vertical open-bore magnetic resonance (MR) scanners, with participants upright and fully weight-bearing; and to evaluate the repeatability of these methods in individuals with patellofemoral osteoarthritis (OA) and in asymptomatic knees. MATERIALS AND METHODS: Our methods extend previously validated, reliable methods for evaluating alignment into an upright MR environment...
August 21, 2017: Journal of Magnetic Resonance Imaging: JMRI
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