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Quantitative myocardial perfusion

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https://www.readbyqxmd.com/read/29790017/machine-learning-in-the-integration-of-simple-variables-for-identifying-patients-with-myocardial-ischemia
#1
Luis Eduardo Juarez-Orozco, Remco J J Knol, Carlos A Sanchez-Catasus, Octavio Martinez-Manzanera, Friso M van der Zant, Juhani Knuuti
BACKGROUND: A significant number of variables are obtained when characterizing patients suspected with myocardial ischemia or at risk of MACE. Guidelines typically use a handful of them to support further workup or therapeutic decisions. However, it is likely that the numerous available predictors maintain intrinsic complex interrelations. Machine learning (ML) offers the possibility to elucidate complex patterns within data to optimize individual patient classification. We evaluated the feasibility and performance of ML in utilizing simple accessible clinical and functional variables for the identification of patients with ischemia or an elevated risk of MACE as determined through quantitative PET myocardial perfusion reserve (MPR)...
May 22, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29778317/appropriate-use-of-noninvasive-ischemia-testing-to-guide-revascularization-decision-making-following-acute-st-elevation-myocardial-infarction-in-latin-american-countries-results-from-an-expert-panel-meeting-of-the-international-atomic-energy-agency
#2
I Berrocal, A Peix, F Mut, L J Shaw, G Karthikeyan, E Estrada Lobato, D Paez
Across Latin American and Caribbean countries, cardiovascular disease and especially ischemic heart disease is currently the main cause of death both in men and in women. For most Latin American and Caribbean countries, public and community health efforts aim to define care strategies which are both clinically and cost effective and promote primary and secondary prevention, resulting in improved patient outcomes. The optimal approach to deal with acute events such as ST-elevation myocardial infarction (STEMI) is a matter of controversy; however, there is an expanding role for assessing residual ischemic burden in STEMI patients following primary percutaneous coronary intervention...
May 16, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29774406/reduced-global-myocardial-perfusion-reserve-in-dcm-and-hcm-patients-assessed-by-cmr-based-velocity-encoded-coronary-sinus-flow-measurements-and-first-pass-perfusion-imaging
#3
Michael Bietenbeck, Anca Florian, Zornitsa Shomanova, Claudia Meier, Ali Yilmaz
BACKGROUND: Coronary microvascular dysfunction (CMD) is an independent predictor of poor prognosis in patients suffering from dilative or hypertrophic cardiomyopathy (DCM/HCM). To assess CMD, quantitative myocardial first-pass perfusion (1P) cardiovascular magnetic resonance (CMR) can be performed. Coronary sinus flow (CSF) measurements at rest and during maximal vasodilatation are an alternative and well-validated approach for the quantification of global myocardial blood flow (MBF) in CMR...
May 17, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29747851/quantitative-myocardial-perfusion-cmr-is-the-game-worth-the-candle
#4
EDITORIAL
Christopher M Kramer, Y Chandrashekhar
No abstract text is available yet for this article.
May 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29747847/quantitative-myocardial-perfusion-imaging-versus-visual-analysis-in-diagnosing-myocardial-ischemia-a-ce-marc-substudy
#5
John D Biglands, Montasir Ibraheem, Derek R Magee, Aleksandra Radjenovic, Sven Plein, John P Greenwood
OBJECTIVES: This study sought to compare the diagnostic accuracy of visual and quantitative analyses of myocardial perfusion cardiovascular magnetic resonance against a reference standard of quantitative coronary angiography. BACKGROUND: Visual analysis of perfusion cardiovascular magnetic resonance studies for assessing myocardial perfusion has been shown to have high diagnostic accuracy for coronary artery disease. However, only a few small studies have assessed the diagnostic accuracy of quantitative myocardial perfusion...
May 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29730016/diagnostic-accuracy-of-semi-automatic-quantitative-metrics-as-an-alternative-to-expert-reading-of-ct-myocardial-perfusion-in-the-core320-study
#6
Mohammad R Ostovaneh, Andrea L Vavere, Vishal C Mehra, Klaus F Kofoed, Matthew B Matheson, Armin Arbab-Zadeh, Yasuko Fujisawa, Joanne D Schuijf, Carlos E Rochitte, Arthur J Scholte, Kakuya Kitagawa, Marc Dewey, Christopher Cox, Marcelo F DiCarli, Richard T George, Joao A C Lima
AIMS: To determine the diagnostic accuracy of semi-automatic quantitative metrics compared to expert reading for interpretation of computed tomography perfusion (CTP) imaging. METHODS: The CORE320 multicenter diagnostic accuracy clinical study enrolled patients between 45 and 85 years of age who were clinically referred for invasive coronary angiography (ICA). Computed tomography angiography (CTA), CTP, single photon emission computed tomography (SPECT), and ICA images were interpreted manually in blinded core laboratories by two experienced readers...
April 3, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29725598/takotsubo-cardiomyopathy-one-more-angiographic-evidence-of-microvascular-dysfunction
#7
Marco Loffi, Andrea Santangelo, Martin Kozel, Viktor Kocka, Tomas Budesinsky, Libor Lisa, Petr Tousek
Background: Takotsubo cardiomyopathy (TC) aetiology has not been completely understood yet. One proposed pathogenic mechanism was coronary microvascular dysfunction (MVD). This study compared coronary flow and myocardial perfusion in patients with TC, microvascular angina (MVA), and a control group (CG). Methods: Out of 42 consecutive patients presented to our centre with TC from 2013 to 2017; we retrospectively selected 27 patients. We compared them with a sex- and age-matched group of 27 MVA cases and 27 patients with normal coronary arteries (CG)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29713770/comprehensive-morphologic-and-functional-imaging-of-heart-transplant-patients-first-experience-with-dynamic-perfusion-ct
#8
S Oebel, S Hamada, K Higashigaito, J von Spiczak, E Klotz, F Enseleit, R Hinzpeter, F Ruschitzka, R Manka, H Alkadhi
OBJECTIVES: We aimed to assess the diagnostic performance of a combined protocol with coronary computed tomography angiography (CCTA) and stress CT perfusion imaging (CTP) in heart transplant patients for comprehensive morphological and functional imaging. METHODS: In this prospective study, 13 patients undergoing routine follow-up 8±6 years after heart transplantation underwent CCTA and dynamic adenosine stress CTP using a third-generation dual-source CT scanner, cardiac magnetic resonance (MR) adenosine stress perfusion imaging at 1...
April 30, 2018: European Radiology
https://www.readbyqxmd.com/read/29703779/impact-of-revascularization-on-absolute-myocardial-blood-flow-as-assessed-by-serial-15-o-h-2-o-positron-emission-tomography-imaging-a-comparison-with-fractional-flow-reserve
#9
Roel S Driessen, Ibrahim Danad, Wijnand J Stuijfzand, Stefan P Schumacher, Juhani Knuuti, Maija Mäki, Adriaan A Lammertsma, Albert C van Rossum, Niels van Royen, Pieter G Raijmakers, Paul Knaapen
BACKGROUND: The main goal of coronary revascularization is to restore myocardial perfusion in case of ischemia, causing coronary artery disease. Yet, little is known on the effect of revascularization on absolute myocardial blood flow (MBF). Therefore, the present prospective study assesses the impact of coronary revascularization on absolute MBF as measured by [15 O]H2 O positron emission tomography and fractional flow reserve (FFR) in patients with stable coronary artery disease. METHODS AND RESULTS: Fifty-three patients (87% men, mean age 58...
May 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29701608/quantitative-myocardial-perfusion-from-static-cardiac-and-dynamic-arterial-ct
#10
Michael Bindschadler, Kelley R Branch, Adam M Alessio
Quantitative myocardial blood flow (MBF) estimation by dynamic contrast enhanced cardiac computed tomography (CT) requires multi-frame acquisition of contrast transit through the blood pool and myocardium to inform the arterial input and tissue response functions. Both the input and the tissue response functions for the entire myocardium are sampled with each acquisition. However, the long breath holds and frequent sampling can result in significant motion artifacts and relatively high radiation dose. To address these limitations, we propose and evaluate a new static cardiac and dynamic arterial (SCDA) quantitative MBF approach where 1) the input function is well sampled using either prediction from pre-scan timing bolus data or measured from dynamic thin slice "bolus tracking" acquisitions, and 2) the whole-heart tissue response data is limited to one contrast enhanced CT acquisition...
April 27, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29700862/the-quantitative-assessment-of-epicardial-fat-distribution-on-human-hearts-implications-for-epicardial-electrophysiology
#11
Alexander R Mattson, Mario J Soto, Paul A Iaizzo
INTRODUCTION: Epicardial electrophysiological procedures rely on dependable interfacing with the myocardial tissue. For example, epicardial pacing systems must generate sustainable chronic pacing capture, while epicardial ablations must effectively deliver energy to the target hyper-excitable myocytes. The human heart has a significant adipose layer which may impede epicardial procedures. The objective of this study was to quantitatively assess the relative location of epicardial adipose on the human heart, in order to define locations where epicardial therapies might be performed successfully...
April 26, 2018: Clinical Anatomy
https://www.readbyqxmd.com/read/29550844/is-there-an-association-between-hibernating-myocardium-and-left-ventricular-mechanical-dyssynchrony-in-patients-with-myocardial-infarction
#12
Feifei Zhang, Wei Yang, Yuetao Wang, Haipeng Tang, Jianfeng Wang, Xiaoliang Shao, Ziyi Wang, Xiaoying Zhang, Ling Yang, Xiaosong Wang, Weihua Zhou
OBJECTIVE: Left ventricular mechanical dyssynchrony (LVMD) is an important factor in the prognosis of patients with myocardial infarction (MI). The aim of this study is to identify the influencing factors of LVMD in MI patients by radionuclide myocardial imaging. SUBJECTS AND METHODS: This study consisted of 91 patients who had a history of definite prior MI and underwent both technetium-99m methoxyisobutylisonitrile (99m Tc-MIBI) gated single photon emission tomography (SPET) myocardial perfusion imaging (MPI) and 18 F-FDG positron emission tomography (PET) myocardial metabolic imaging...
January 2018: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29550305/deep-learning-for-prediction-of-obstructive-disease-from-fast-myocardial-perfusion-spect-a-multicenter-study
#13
Julian Betancur, Frederic Commandeur, Mahsaw Motlagh, Tali Sharir, Andrew J Einstein, Sabahat Bokhari, Mathews B Fish, Terrence D Ruddy, Philipp Kaufmann, Albert J Sinusas, Edward J Miller, Timothy M Bateman, Sharmila Dorbala, Marcelo Di Carli, Guido Germano, Yuka Otaki, Balaji K Tamarappoo, Damini Dey, Daniel S Berman, Piotr J Slomka
OBJECTIVES: The study evaluated the automatic prediction of obstructive disease from myocardial perfusion imaging (MPI) by deep learning as compared with total perfusion deficit (TPD). BACKGROUND: Deep convolutional neural networks trained with a large multicenter population may provide improved prediction of per-patient and per-vessel coronary artery disease from single-photon emission computed tomography MPI. METHODS: A total of 1,638 patients (67% men) without known coronary artery disease, undergoing stress 99m Tc-sestamibi or tetrofosmin MPI with new generation solid-state scanners in 9 different sites, with invasive coronary angiography performed within 6 months of MPI, were studied...
March 12, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29514708/fully-quantitative-pixel-wise-analysis-of-cardiovascular-magnetic-resonance-perfusion-improves-discrimination-of-dark-rim-artifact-from-perfusion-defects-associated-with-epicardial-coronary-stenosis
#14
Allison D Ta, Li-Yueh Hsu, Hannah M Conn, Susanne Winkler, Anders M Greve, Sujata M Shanbhag, Marcus Y Chen, W Patricia Bandettini, Andrew E Arai
BACKGROUND: Dark rim artifacts in first-pass cardiovascular magnetic resonance (CMR) perfusion images can mimic perfusion defects and affect diagnostic accuracy for coronary artery disease (CAD). We evaluated whether quantitative myocardial blood flow (MBF) can differentiate dark rim artifacts from true perfusion defects in CMR perfusion. METHODS: Regadenoson perfusion CMR was performed at 1.5 T in 76 patients. Significant CAD was defined by quantitative invasive coronary angiography (QCA) ≥ 50% diameter stenosis...
March 8, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29471856/quantitative-cardiovascular-magnetic-resonance-perfusion-imaging-identifies-reduced-flow-reserve-in-microvascular-coronary-artery-disease
#15
Benjamin Zorach, Peter W Shaw, Jamieson Bourque, Sujith Kuruvilla, Pelbreton C Balfour, Yang Yang, Roshin Mathew, Jonathan Pan, Jorge A Gonzalez, Angela M Taylor, Craig H Meyer, Frederick H Epstein, Christopher M Kramer, Michael Salerno
BACKGROUND: Preliminary semi-quantitative cardiovascular magnetic resonance (CMR) perfusion studies have demonstrated reduced myocardial perfusion reserve (MPR) in patients with angina and risk factors for microvascular disease (MVD), however fully quantitative CMR has not been studied. The purpose of this study is to evaluate whether fully quantitative CMR identifies reduced MPR in this population, and to investigate the relationship between epicardial atherosclerosis, left ventricular hypertrophy (LVH), extracellular volume (ECV), and perfusion...
February 22, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29470136/-15-o-h-2-o-pet-ct-as-a-tool-for-the-quantitative-assessement-of-early-post-radiotherapy-changes-of-heart-perfusion-in-breast-carcinoma-patients
#16
Agnieszka Żyromska, Bogdan Małkowski, Tomasz Wiśniewski, Karolina Majewska, Joanna Reszke, Roman Makarewicz
OBJECTIVE: Studies examining radiation-induced heart toxicity in breast cancer patients are inconclusive. The aim of this study was to prospectively and quantitatively asses myocardial blood flow (MBF) with, for the first time, 15O-H2O PET/CT as a marker of heart damage in irradiated breast cancer patients. METHODS: Fifteen breast cancer patients receiving intact breast or chest wall irradiation were included in the analysis (six with right-sided and nine with left-sided breast cancer)...
February 22, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29454767/diagnostic-performance-of-fully-automated-pixel-wise-quantitative-myocardial-perfusion-imaging-by-cardiovascular-magnetic-resonance
#17
Li-Yueh Hsu, Matthew Jacobs, Mitchel Benovoy, Allison D Ta, Hannah M Conn, Susanne Winkler, Anders M Greve, Marcus Y Chen, Sujata M Shanbhag, W Patricia Bandettini, Andrew E Arai
OBJECTIVES: The authors developed a fully automated framework to quantify myocardial blood flow (MBF) from contrast-enhanced cardiac magnetic resonance (CMR) perfusion imaging and evaluated its diagnostic performance in patients. BACKGROUND: Fully quantitative CMR perfusion pixel maps were previously validated with microsphere MBF measurements and showed potential in clinical applications, but the methods required laborious manual processes and were excessively time-consuming...
February 9, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29442348/quantitation-in-dextrocardia-on-myocardial-perfusion-imaging-how-to-perform-quantitative-analysis-using-cedars-sinai-software
#18
Mohsen Qutbi, Mehdi Soltanshahi, Mojtaba Ansari, Hoda Hashemi, Isa Neshandar Asli, Babak Shafiei
Dextrocardia, although a rare cardiac abnormality, carries the same risk for cardiac events as other people. SPECT Myocardial perfusion imaging is a potentially helpful diagnostic tool in patients with dextrocardia. Because of swapping of lateral and septal walls on SPECT slices, although visual analysis is possible, quantitation is substantially limited. Here, we introduce a simple practical method to make quantitative analysis feasible and accurate.
2018: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/29430112/role-of-myocardial-perfusion-study-in-differentiating-ischemic-versus-nonischemic-cardiomyopathy-using-quantitative-parameters
#19
Preeti Singh, Bhairavi Bhatt, Shwetal U Pawar, Ashish Kamra, Suruchi Shetye, Mangala Ghorpade
Purpose: Ischemic cardiomyopathy (ICM) and non-ICM (NICM) causes of dilated cardiomyopathy with similar clinical presentation have different management and prognosis. This study employed myocardial perfusion imaging (MPI) to differentiate between the two using quantitative parameters in Indian population. Methods and Materials: Fifty patients prospectively underwent MPI and 18 F-fluorodeoxyglucose metabolism studies. P values (0.05 as significant) were calculated for the left ventricular ejection fraction (EF), end diastolic volume (EDV) at rest and stress, end systolic volume (ESV) at rest and stress, summed rest score (SRS), summed difference score (SDS), and eccentricity...
January 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29430109/comparison-of-left-ventricular-phase-parameters-analysis-between-two-software-programs-in-patients-with-normal-gated-single-photon-emission-computed-tomography-myocardial-perfusion-imaging
#20
Dharmender Malik, Ashwani Sood, Madan Parmar, Bhagwant Rai Mittal
Background: Phase analysis can be easily performed by different software to assess the left ventricular dyssynchrony from gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) with high precision. However, the normal values of histogram bandwidth (HBW) and phase standard deviation (PSD) and their comparison using different programs have not been fully elucidated and actively being evaluated at present. The aim of this study was to determine the phase analysis parameters values and to compare the phase indices of two commonly used programs in a group of patients with normal gated SPECT-MPI...
January 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
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