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Quantitative myocardial perfusion

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https://www.readbyqxmd.com/read/28905206/improved-diagnosis-of-the-number-of-stenosed-coronary-artery-vessels-by-segmentation-with-scatter-and-photo-peak-window-data-for-attenuation-correction-in-myocardial-perfusion-spect
#1
Yohei Yamauchi, Yumiko Kanzaki, Masuo Hayashi, Mami Arai, Hideaki Morita, Tsuyoshi Komori, Masaaki Hoshiga, Nobukazu Ishizaka
BACKGROUND: Attenuation correction using segmentation of scatter and photo-peak window data (SSPAC) enables an evaluation of the attenuation map in a patient-specific manner without additional radiation exposure. We compared the accuracy of SSPAC and non-corrected myocardial perfusion scintigraphy methods for diagnosing the number of stenosed coronary artery vessels. METHODS AND RESULTS: We retrospectively reviewed the data from 183 consecutive patients who underwent (99m)Tc-tetrofosmin stress/rest SPECT examination and a coronary angiography within 3 months...
September 13, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28901610/low-dose-dynamic-myocardial-perfusion-ct-imaging-using-a-motion-adaptive-sparsity-prior
#2
Zhaoying Bian, Dong Zeng, Zhang Zhang, Changfei Gong, Xiumei Tian, Gang Yan, Jing Huang, Hong Guo, Bo Chen, Jing Zhang, Qianjin Feng, Wufan Chen, Jianhua Ma
PURPOSE: Dynamic myocardial perfusion computed tomography (DM-PCT) imaging offers benefits over quantitative assessment of myocardial blood flow (MBF) for diagnosis and risk stratification of coronary artery disease. However, one major drawback of DM-PCT imaging is that a high radiation level is imparted by repeated scanning. To address this issue, in this work, we developed a statistical iterative reconstruction algorithm based on the penalized weighted least-squares (PWLS) scheme by incorporating a motion adaptive sparsity prior (MASP) model to achieve high-quality DM-PCT imaging with low tube current dynamic data acquisition...
September 2017: Medical Physics
https://www.readbyqxmd.com/read/28885540/stress-only-myocardial-perfusion-scintigraphy-a-prospective-study-on-the-accuracy-and-observer-agreement-with-quantitative-coronary-angiography-as-the-gold-standard
#3
June A Ejlersen, Ole May, Jesper Mortensen, Gitte L Nielsen, Jeppe F Lauridsen, Johansen Allan
OBJECTIVE: Patients with normal stress perfusion have an excellent prognosis. Prospective studies on the diagnostic accuracy of stress-only scans with contemporary, independent examinations as gold standards are lacking. PATIENTS AND METHODS: A total of 109 patients with typical angina and no previous coronary artery disease underwent a 2-day stress (exercise)/rest, gated, and attenuation-corrected (AC), 99m-technetium-sestamibi perfusion study, followed by invasive coronary angiography...
September 6, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28880152/an-open-benchmark-challenge-for-motion-correction-of-myocardial-perfusion-mri
#4
Beau Pontre, Brett R Cowan, Edward DiBella, Sancgeetha Kulaseharan, Devavrat Likhite, Nils Noorman, Lennart Tautz, Nicholas Tustison, Gert Wollny, Alistair A Young, Avan Suinesiaputra
Cardiac magnetic resonance perfusion examinations enable noninvasive quantification of myocardial blood flow. However, motion between frames due to breathing must be corrected for quantitative analysis. Although several methods have been proposed, there is a lack of widely available benchmarks to compare different algorithms. We sought to compare many algorithms from several groups in an open benchmark challenge. Nine clinical studies from two different centers comprising normal and diseased myocardium at both rest and stress were made available for this study...
September 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28866488/radiation-dose-reduction-in-ct-myocardial-perfusion-imaging-using-smart-recon
#5
Yinsheng Li, Michael A Speidel, Christopher J Francois, Guang-Hong Chen
In this work, a newly developed statistical model based image reconstruction (referred to as Simultaneous Multiple Artifacts Reduction in Tomographic RECONstruction (SMARTRECON) [1]) is applied to low dose computer tomography (CT) myocardial perfusion imaging (CT-MPI). This method uses the nuclear norm of the spatial-temporal image matrix of the CTMPI images as a regularizer, rather than a conventional spatial regularizer that incorporates image smoothness, edge preservation, or spatial sparsity into the reconstruction...
August 30, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28865679/quantification-of-myocardial-perfusion-reserve-using-dynamic-spect-images-of-patients-with-chronic-kidney-disease
#6
Noriko Tsuda, Shinya Shiraishi, Fumi Sakamoto, Hideaki Yuki, Koji Ogasawara, Morikatsu Yoshida, Seiji Tomiguchi, Kenichi Tsujita, Yasuyuki Yamashita
BACKGROUND: Chronic kidney disease (CKD) is an independent risk factor for cardiovascular disorders. The aim of this study was to examine whether the quantitatively measured myocardial blood flow (MBF) or myocardial perfusion reserve (MPR), calculated by dynamic single photon emission computed tomography (SPECT) analysis using a cardiac cadmium zinc telluride (CZT) gamma camera, was related to renal dysfunction in patients with normal myocardial perfusion imaging (MPI) findings. METHODS: The study population consisted of 46 patients with CKD and 46 individuals without CKD (controls)...
August 30, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28856412/accurate-late-gadolinium-enhancement-prediction-by-early-t1-based-quantitative-synthetic-mapping
#7
Randy van Dijk, Dirkjan Kuijpers, Theodorus A M Kaandorp, Paul R M van Dijkman, Rozemarijn Vliegenthart, Pim van der Harst, Matthijs Oudkerk
OBJECTIVES: Early synthetic gadolinium enhancement (ESGE) imaging from post-contrast T1 mapping after adenosine stress-perfusion cardiac magnetic resonance (CMR) was compared to conventional late gadolinium enhancement (LGE) imaging for assessing myocardial scar. METHODS: Two hundred fourteen consecutive patients suspected of myocardial ischaemia were referred for stress-perfusion CMR. Myocardial infarct volume was quantified on a per-subsegment basis in both synthetic (2-3 min post-gadolinium) and conventional (9 min post-gadolinium) images by two independent observers...
August 30, 2017: European Radiology
https://www.readbyqxmd.com/read/28798137/cmr-native-t1-mapping-allows-differentiation-of-reversible-versus-irreversible-myocardial-damage-in-st-segment-elevation-myocardial-infarction-an-oxami-study-oxford-acute-myocardial-infarction
#8
Dan Liu, Alessandra Borlotti, Dafne Viliani, Michael Jerosch-Herold, Mohammad Alkhalil, Giovanni Luigi De Maria, Gregor Fahrni, Sam Dawkins, Rohan Wijesurendra, Jane Francis, Vanessa Ferreira, Stefan Piechnik, Matthew D Robson, Adrian Banning, Robin Choudhury, Stefan Neubauer, Keith Channon, Rajesh Kharbanda, Erica Dall'Armellina
BACKGROUND: CMR T1 mapping is a quantitative imaging technique allowing the assessment of myocardial injury early after ST-segment-elevation myocardial infarction. We sought to investigate the ability of acute native T1 mapping to differentiate reversible and irreversible myocardial injury and its predictive value for left ventricular remodeling. METHODS AND RESULTS: Sixty ST-segment-elevation myocardial infarction patients underwent acute and 6-month 3T CMR, including cine, T2-weighted (T2W) imaging, native shortened modified look-locker inversion recovery T1 mapping, rest first pass perfusion, and late gadolinium enhancement...
August 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28794138/quantitative-assessment-of-coronary-microvascular-function-dynamic-single-photon-emission-computed-tomography-positron-emission-tomography-ultrasound-computed-tomography-and-magnetic-resonance-imaging
#9
REVIEW
Attila Feher, Albert J Sinusas
A healthy, functional microcirculation in combination with nonobstructed epicardial coronary arteries is the prerequisite of normal myocardial perfusion. Quantitative assessment in myocardial perfusion and determination of absolute myocardial blood flow can be achieved noninvasively using dynamic imaging with multiple imaging modalities. Extensive evidence supports the clinical value of noninvasively assessing indices of coronary flow for diagnosing coronary microvascular dysfunction; in certain diseases, the degree of coronary microvascular impairment carries important prognostic relevance...
August 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28776314/a-combined-static-dynamic-single-dose-imaging%C3%A2-protocol-to-compare-quantitative-dynamic-spect-with-static-conventional-spect
#10
Maria Sciammarella, Uttam M Shrestha, Youngho Seo, Grant T Gullberg, Elias H Botvinick
BACKGROUND: SPECT myocardial perfusion imaging (MPI) is a clinical mainstay that is typically performed with static imaging protocols and visually or semi-quantitatively assessed for perfusion defects based upon the relative intensity of myocardial regions. Dynamic cardiac SPECT presents a new imaging technique based on time-varying information of radiotracer distribution, which permits the evaluation of regional myocardial blood flow (MBF) and coronary flow reserve (CFR). In this work, a preliminary feasibility study was conducted in a small patient sample designed to implement a unique combined static-dynamic single-dose one-day visit imaging protocol to compare quantitative dynamic SPECT with static conventional SPECT for improving the diagnosis of coronary artery disease (CAD)...
August 3, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28755984/penehyclidine-hydrochloride-preconditioning-provides-cardiac-protection-in-a-rat-model-of-myocardial-ischemia-reperfusion-injury-via-the-mechanism-of-mitochondrial-dynamics-mechanism
#11
Yanli Yang, Liyun Zhao, Jun Ma
To investigate that penehyclidine hydrochloride (PHC) plays a cardiac protection role in myocardial ischemia/reperfusion injury (IRI) through mitochondrial dynamics mechanism. Rat model of myocardial I/R injury was established by the ligation of left anterior descending coronary artery for 30min followed by 3h perfusion. Before I/R, the rats were pretreated with or without PHC. Cardiac function was measured by echocardiography. The activities/levels of myocardial enzymes, oxidants and antioxidant enzymes were detected...
July 26, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28750502/geographic-and-demographic-variabilities-of-quantitative-parameters-in-stress-myocardial-computed-tomography-perfusion
#12
Jinoh Park, Hyun-Sook Kim, Hye Jeon Hwang, Dong Hyun Yang, Hyun Jung Koo, Joon-Won Kang, Young-Hak Kim
BACKGROUND/AIMS: To evaluate the geographic and demographic variabilities of the quantitative parameters of computed tomography perfusion (CTP) of the left ventricular (LV) myocardium in patients with normal coronary artery on computed tomography angiography (CTA). METHODS: From a multicenter CTP registry of stress and static computed tomography, we retrospectively recruited 113 patients (mean age, 60 years; 57 men) without perfusion defect on visual assessment and minimal (< 20% of diameter stenosis) or no coronary artery disease on CTA...
September 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28744708/topics-of-nuclear-medicine-research-in-europe
#13
REVIEW
Masayuki Inubushi, Tomohiro Kaneta, Takayoshi Ishimori, Etsuko Imabayashi, Atsutaka Okizaki, Naohiko Oku
Last year in the European Journal of Nuclear Medicine and Molecular Imaging, we introduced some recent nuclear medicine research conducted in Japan. This was favorably received by European readers in the main. This year we wish to focus on the Annals of Nuclear Medicine on some of the fine nuclear medicine research work executed in Europe recently. In the current review article, we take up five topics: prostate-specific membrane antigen imaging, recent advances in radionuclide therapy, [(18)F]fluorodeoxyglucose positron-emission tomography (PET) for dementia, quantitative PET assessment of myocardial perfusion, and iodine-124 ((124)I)...
July 25, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28726076/ejection-fraction-in-myocardial-perfusion-imaging-assessed-with-a-dynamic-phantom-comparison-between-iq-spect-and-lehr
#14
Eero Hippeläinen, Teemu Mäkelä, Touko Kaasalainen, Erna Kaleva
BACKGROUND: Developments in single photon emission tomography instrumentation and reconstruction methods present a potential for decreasing acquisition times. One of such recent options for myocardial perfusion imaging (MPI) is IQ-SPECT. This study was motivated by the inconsistency in the reported ejection fraction (EF) and left ventricular (LV) volume results between IQ-SPECT and more conventional low-energy high-resolution (LEHR) collimation protocols. IQ-SPECT and LEHR quantitative results were compared while the equivalent number of iterations (EI) was varied...
December 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28712068/qualitative-angiographic-and-quantitative-myocardial-perfusion-assessment-using-fluorescent-cardiac-imaging-during-graded-coronary-artery-bypass-stenosis
#15
Christian Detter, Detlef Russ, Jan Felix Kersten, Hermann Reichenspurner, Sabine Wipper
Intraoperative graft assessment in coronary artery bypass (CAB) grafting is important to avoid early graft failure. This study aimed to evaluate the accuracy of fluorescent cardiac imaging (FCI) for intraoperative qualitative angiographic and quantitative myocardial perfusion assessment during graded CAB stenosis compared to coronary angiography (CA). After CAB grafting to the left anterior descending coronary artery, graded distal bypass stenoses were created in ten pigs by 25, 50, 75, and 100% flow reduction assessed by transit-time flow measurement (TTFM)...
July 15, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28693906/reproducible-computer-assisted-quantification-of-myocardial-perfusion-with-contrast-enhanced-ultrasound
#16
Yuanwei Li, Navtej Chahal, Roxy Senior, Meng-Xing Tang
Myocardial perfusion can be quantified by myocardial contrast echocardiography (MCE) and is used for the diagnosis of coronary artery disease (CAD). However, existing MCE quantification software is highly operator dependent and has poor reproducibility and ease of usage. The aim of this study was to develop robust and easy-to-use software that can perform MCE quantification accurately, reproducibly and rapidly. The developed software has the following features: (i) semi-automatic segmentation of the myocardium; (ii) automatic rejection of MCE data with poor image quality; (iii) automatic computation of perfusion parameters such as myocardial blood flow (MBF)...
July 7, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28692492/criteria-for-the-addition-of-prone-imaging-to-myocardial-perfusion-single-photon-emission-computed-tomography-for-inferior-wall
#17
Koji Nakaya, Masahisa Onoguchi, Yoshihiro Nishimura, Keisuke Kiso, Hideki Otsuka, Yoshifumi Nouno, Takayuki Shibutani, Eisuke Yasuda
OBJECTIVE: Myocardial perfusion single-photon emission computed tomography (SPECT) is occasionally suspected to generate images that represent either ischemia or infarction for the inferior wall [right coronary artery (RCA) disease] or attenuation artifacts because of the diaphragm. We often encounter this. The application of prone imaging is advantageous in the differentiation of RCA disease because of attenuation artifacts. If decreased accumulation of radioisotopes is observed at the site with either RCA disease or attenuation artifacts, then a criterion that enables the addition of prone imaging should be implemented...
July 7, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28685253/detection-and-quantitation-of-right-ventricular-reversible-perfusion-defects-by-stress-spect-myocardial-perfusion-imaging-a-proof-of-principle-study
#18
Ayman A Farag, Jack Heo, Lindsey Tauxe, Pradeep Bhambhvani, Guido Germano, Paul Kavanagh, Ami E Iskandrian, Fadi G Hage
BACKGROUND: In patients with right dominant coronary circulation, the right ventricular (RV) myocardium and the inferior region of the left ventricular (LV) myocardium share a common source of blood flow. We hypothesized that stress/rest SPECT myocardial perfusion imaging (MPI) could detect reversible perfusion defects in the RV in some patients with LV inferior wall perfusion abnormalities. MATERIAL AND METHODS: We identified 2 groups of patients with LV inferior wall perfusion defects (with or without defects in other regions of LV myocardium) from our database...
July 6, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28685251/corrected-coronary-opacification-decrease-from-coronary-computed-tomography-angiography-validation-with-quantitative-13n-ammonia-positron-emission-tomography
#19
Dominik C Benz, Christoph Gräni, Paola Ferro, Luis Neumeier, Michael Messerli, Mathias Possner, Olivier F Clerc, Catherine Gebhard, Oliver Gaemperli, Aju P Pazhenkottil, Philipp A Kaufmann, Ronny R Buechel
BACKGROUND: To assess the functional relevance of a coronary artery stenosis, corrected coronary opacification (CCO) decrease derived from coronary computed tomography angiography (CCTA) has been proposed. The present study aims at validating CCO decrease with quantitative 13N-ammonia positron emission tomography (PET) myocardial perfusion imaging (MPI). METHODS AND RESULTS: This retrospective study consists of 39 patients who underwent hybrid CCTA/PET-MPI. From CCTA, attenuation in the coronary lumen was measured before and after a stenosis and corrected to the aorta to calculate CCO and its decrease...
July 6, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28685228/relationship-between-coronary-contrast-flow-quantitative-flow-ratio-and-myocardial-ischemia-assessed-by-spect-mpi
#20
Jeff M Smit, Gerhard Koning, Alexander R van Rosendael, Petra Dibbets-Schneider, Bart J Mertens, J Wouter Jukema, Victoria Delgado, Johan H C Reiber, Jeroen J Bax, Arthur J Scholte
PURPOSE: A new method has been developed to calculate fractional flow reserve (FFR) from invasive coronary angiography, the so-called "contrast-flow quantitative flow ratio (cQFR)". Recently, cQFR was compared to invasive FFR in intermediate coronary lesions showing an overall diagnostic accuracy of 85%. The purpose of this study was to investigate the relationship between cQFR and myocardial ischemia assessed by single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI)...
July 6, 2017: European Journal of Nuclear Medicine and Molecular Imaging
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