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Quantitative myocardial perfusion

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https://www.readbyqxmd.com/read/29131283/quantitative-myocardial-blush-score-qube-allows-the-prediction-of-heart-failure-development-in-long-term-follow-up-in-patients-with-st-elevation-myocardial-infarction-proof-of-concept-study
#1
Andrzej Tomasik, Tomasz Młyńczak, Edyta Nowak, Katarzyna Pigoń, Artur Iwasieczko, Mariusz Opara, Ewa Nowalany-Kozielska
BACKGROUND: Acute myocardial infarction (AMI) might lead to left ventricular remodeling. Adequate myocardial perfusion is critical to prevent this adverse remodeling. Quantitative myocardial blush evaluator (QuBE) software, available on-line, is a simple analysis tool which enables the precise quantification of myocardial perfusion in the infarct area immediately after interventional treatment. The aim of this study was to assess whether the results of QuBE analysis might predict the development of HF in AMI patients in 3 year-long follow-up...
November 13, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/29127239/a-novel-method-for-quantitative-myocardial-contrast-echocardiography-in-mice
#2
Erika Alvarez, Nancy D Dalton, Yusu Gu, Dan Smith, Alice Luong, Masahiko Hoshijima, Kirk L Peterson, Joshua Rychak
The small size of the mouse heart frequently imparts technical challenges when applying conventional in vivo imaging methods for assessing heart function. Here we describe the use of high frequency ultrasound imaging in conjunction with a size-tuned blood pool contrast agent for quantitatively assessing myocardial perfusion in living mice. A perflurocarbon microbubble formulation exhibiting a narrow size distribution was developed, and echogenicity assessed at 18 MHz in vitro. Adult mice were subjected to permanent ligation of the left anterior descending artery...
November 10, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29118884/breast-arterial-calcifications-on-mammography-do-not-predict-myocardial-ischemia-on-myocardial-perfusion-single-photon-emission-computed-tomography
#3
Ahmed Fathala, Salma Salem, Fahad Alanazi, Deema Abunayyan, Abdelmoneim M Eldali, Abdulaziz Alsugair
Background: The aim of this study was to determine if breast arterial calcification (BAC) on mammography predicts myocardial ischemia (MI) on stress myocardial perfusion single-photon emission computed tomography (MPS). BAC is a type of medial artery calcification that can be seen incidentally on mammography, but the relationship between coronary artery calcification and MI on MPS is yet unknown. Methods: A total of 435 consecutive women underwent mammography and stress MPS within 1 year of each other...
October 2017: Cardiology Research
https://www.readbyqxmd.com/read/29110669/a-comparison-of-cardiovascular-magnetic-resonance-and-single-photon-emission-computed-tomography-spect-perfusion-imaging-in-left-main-stem-or-equivalent-coronary-artery-disease-a-ce-marc-substudy
#4
James R J Foley, Ananth Kidambi, John D Biglands, Neil Maredia, Catherine J Dickinson, Sven Plein, John P Greenwood
BACKGROUND: Assessment of left main stem (LMS) stenosis has prognostic and therapeutic implications. Data on assessment of LMS disease by cardiovascular magnetic resonance (CMR) and single photon emission computed tomography (SPECT) are limited. CE-MARC is the largest prospective comparison of CMR and SPECT against quantitative invasive coronary angiography (QCA) for detection of coronary artery disease (CAD), and provided the framework for this evaluation. The aims of this study were to compare diagnostic accuracy of visual and quantitative perfusion CMR to SPECT in patients with LMS stable CAD...
November 6, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29055639/prognostic-value-of-combined-clinical-and-myocardial-perfusion-imaging-data-using-machine-learning
#5
Julian Betancur, Yuka Otaki, Manish Motwani, Mathews B Fish, Mark Lemley, Damini Dey, Heidi Gransar, Balaji Tamarappoo, Guido Germano, Tali Sharir, Daniel S Berman, Piotr J Slomka
OBJECTIVES: This study evaluated the added predictive value of combining clinical information and myocardial perfusion single-photon emission computed tomography (SPECT) imaging (MPI) data using machine learning (ML) to predict major adverse cardiac events (MACE). BACKGROUND: Traditionally, prognostication by MPI has relied on visual or quantitative analysis of images without objective consideration of the clinical data. ML permits a large number of variables to be considered in combination and at a level of complexity beyond the human clinical reader...
October 16, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29051079/reduced-myocardial-flow-reserve-is-associated-with-diastolic-dysfunction-and-decreased-left-atrial-strain-in-patients-with-normal-ejection-fraction-and-epicardial-perfusion
#6
Matthew C Konerman, Joshua C Greenberg, Theodore J Kolias, James R Corbett, Ravi V Shah, Venkatesh L Murthy, Scott L Hummel
INTRODUCTION: Coronary microvascular dysfunction (MVD) may contribute to the pathogenesis of heart failure with preserved ejection fraction (HFpEF). Speckle-tracking echocardiography is a feasible and reproducible method for identifying abnormalities in left ventricular (LV) and left atrial (LA) function among HFpEF patients. By assessing myocardial flow reserve (MFR), positron emission tomography (PET) imaging enables quantitative assessment of coronary MVD. We hypothesized that, in patients with risk factors for HFpEF and normal epicardial perfusion on cardiac PET, abnormal MFR is associated with LV diastolic dysfunction (DD) and reduced LV and LA strain...
October 16, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29047385/fully-quantitative-cardiovascular-magnetic-resonance-myocardial-perfusion-ready-for-clinical-use-a-comparison-between-cardiovascular-magnetic-resonance-imaging-and-positron-emission-tomography
#7
Henrik Engblom, Hui Xue, Shahnaz Akil, Marcus Carlsson, Cecilia Hindorf, Jenny Oddstig, Fredrik Hedeer, Michael S Hansen, Anthony H Aletras, Peter Kellman, Håkan Arheden
BACKGROUND: Recent studies have shown that quantification of myocardial perfusion (MP) at stress and myocardial perfusion reserve (MPR) offer additional diagnostic and prognostic information compared to qualitative and semi-quantitative assessment of myocardial perfusion distribution in patients with coronary artery disease (CAD). Technical advancements have enabled fully automatic quantification of MP using cardiovascular magnetic resonance (CMR) to be performed in-line in a clinical workflow...
October 19, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29040168/failure-of-isoflurane-cardiac-preconditioning-in-obese-type-2-diabetic-mice-involves-aberrant-regulation-of-microrna-21-endothelial-nitric-oxide-synthase-and-mitochondrial-complex-i
#8
Zhi-Dong Ge, Yingchuan Li, Shigang Qiao, Xiaowen Bai, David C Warltier, Judy R Kersten, Zeljko J Bosnjak, Mingyu Liang
BACKGROUND: Diabetes impairs the cardioprotective effect of volatile anesthetics, yet the mechanisms are still murky. We examined the regulatory effect of isoflurane on microRNA-21, endothelial nitric-oxide synthase, and mitochondrial respiratory complex I in type II diabetic mice. METHODS: Myocardial ischemia/reperfusion injury was produced in obese type 2 diabetic (db/db) and C57BL/6 control mice ex vivo in the presence or absence of isoflurane administered before ischemia...
October 17, 2017: Anesthesiology
https://www.readbyqxmd.com/read/29034066/novel-spect-technologies-and-approaches-in-cardiac-imaging
#9
Piotr Slomka, Guang-Uei Hung, Guido Germano, Daniel S Berman
Recent novel approaches in myocardial perfusion single photon emission CT (SPECT) have been facilitated by new dedicated high-efficiency hardware with solid-state detectors and optimized collimators. New protocols include very low-dose (1 mSv) stress-only, two-position imaging to mitigate attenuation artifacts, and simultaneous dual-isotope imaging. Attenuation correction can be performed by specialized low-dose systems or by previously obtained CT coronary calcium scans. Hybrid protocols using CT angiography have been proposed...
December 1, 2016: Cardiovasc Innov Appl
https://www.readbyqxmd.com/read/29029074/multimodality-imaging-evaluation-of-chagas-disease-an-expert-consensus-of-brazilian-cardiovascular-imaging-department-dic-and-the-european-association-of-cardiovascular-imaging-eacvi
#10
Maria Carmo P Nunes, Luigi Paolo Badano, J Antonio Marin-Neto, Thor Edvardsen, Covadonga Fernández-Golfín, Chiara Bucciarelli-Ducci, Bogdan A Popescu, Richard Underwood, Gilbert Habib, Jose Luis Zamorano, Roberto Magalhães Saraiva, Ester Cerdeira Sabino, Fernando A Botoni, Márcia Melo Barbosa, Marcio Vinicius L Barros, Eduardo Falqueto, Marcus Vinicius Simões, André Schmidt, Carlos Eduardo Rochitte, Manoel Otávio Costa Rocha, Antonio Luiz Pinho Ribeiro, Patrizio Lancellotti
Aims: To develop a document by Brazilian Cardiovascular Imaging Department (DIC) and the European Association of Cardiovascular Imaging (EACVI) to review and summarize the most recent evidences about the non-invasive assessment of patients with Chagas disease, with the intent to set up a framework for standardized cardiovascular imaging to assess cardiovascular morphologic and functional disturbances, as well as to guide the subsequent process of clinical decision-making. Methods and results: Chagas disease remains one of the most prevalent infectious diseases in Latin America, and has become a health problem in non-endemic countries...
September 25, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28984890/multi-centre-study-of-whole-heart-dynamic-3d-cardiac-magnetic-resonance-perfusion-imaging-for-the-detection-of-coronary-artery-disease-defined-by-fractional-flow-reserve-gender-based-analysis-of-diagnostic-performance
#11
Sandra Hamada, Alexander Gotschy, Lukas Wissmann, Ingo Paetsch, Cosima Jahnke, Sven Plein, Rolf Gebker, Sabrina Oebel, Hatem Alkadhi, Nikolaus Marx, Thomas F Lüscher, Sebastian Kozerke, Robert Manka
Aims: Coronary artery disease (CAD) is a leading cause of morbidity and mortality in women and non-invasive testing for CAD in women can be more challenging than in men. This study compared the diagnostic performance of whole-heart dynamic 3D cardiovascular magnetic resonance (CMR) stress perfusion imaging in female and male patients with quantitative coronary angiography (QCA) and fractional flow reserve (FFR) as reference tests. Methods and results: Four hundred sixteen patients with suspected or known CAD were enrolled in five European centres...
October 1, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28976333/a-comparison-of-iterative-reconstruction-and-prone-imaging-in-reducing-the-inferior-wall-attenuation-in-tc-99m-sestamibi-myocardial-perfusion-spect
#12
Duygu Kuşlu, Emel Öztürk
OBJECTIVE: Prone positioning, iterative reconstruction (IR-OSEM) and electrocardiography (ECG) gating have been demonstrated to improve the specificity of myocardial perfusion SPECT (MPS) in the diagnosis of coronary artery disease. METHODS: The gated supine and prone MPS images of 45 patients were reconstructed with both IR-OSEM [supine (SIR) and prone (PIR)] FBPs [supine (SFBP), prone (PFBP)] for comparison. Perfusion, wall motion (WM) and wall thickening were also interpreted semi-quantitatively...
October 3, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28956734/coronary-artery-disease-analysis-of-diagnostic-performance-of-ct-perfusion-and-mr-perfusion-imaging-in-comparison-with-quantitative-coronary-angiography-and-spect-multicenter-prospective-trial
#13
Matthias Rief, Marcus Y Chen, Andrea L Vavere, Benjamin Kendziora, Julie M Miller, W Patricia Bandettini, Christopher Cox, Richard T George, João Lima, Marcelo Di Carli, Michail Plotkin, Elke Zimmermann, Michael Laule, Peter Schlattmann, Andrew E Arai, Marc Dewey
Purpose To compare the diagnostic performance of stress myocardial computed tomography (CT) perfusion with that of stress myocardial magnetic resonance (MR) perfusion imaging in the detection of coronary artery disease (CAD). Materials and Methods All patients gave written informed consent prior to inclusion in this institutional review board-approved study. This two-center substudy of the prospective Combined Noninvasive Coronary Angiography and Myocardial Perfusion Imaging Using 320-Detector Row Computed Tomography (CORE320) multicenter trial included 92 patients (mean age, 63...
September 25, 2017: Radiology
https://www.readbyqxmd.com/read/28956317/the-role-of-nuclear-medicine-in-assessments-of-cardiac-dyssynchrony
#14
Masanao Naya, Osamu Manabe, Kazuhiro Koyanagawa, Nagara Tamaki
Radionuclide imaging has an advantage for quantitative analyses of the tracer concentration and its temporal changes. Myocardial perfusion and function have been adapted for synchrony analyses. Extracted parameters have been demonstrated to measure ventricular synchrony and even to predict CRT outcomes. ERNA has the advantages of higher temporal resolution, greater reproducibility, and the volumetric analysis of both ventricles that can be applied for analyses of intraventricular synchrony and interventricular synchrony...
September 27, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28956115/ct-myocardial-perfusion-imaging-ready-for-prime-time
#15
EDITORIAL
Richard A P Takx, Csilla Celeng, U Joseph Schoepf
The detection of functional coronary artery stenosis with coronary CT angiography (CCTA) is suboptimal. Additional CT myocardial perfusion imaging (CT-MPI) may be helpful to identify patients with myocardial ischaemia in whom coronary revascularization therapy would be beneficial. CT-MPI adds incremental diagnostic and prognostic value over obstructive disease on CCTA. It allows for the quantitation of myocardial blood flow and calculation of coronary flow reserve and shows good correlation with (15)O-H2O positron emission tomography and invasive fractional flow reserve...
September 27, 2017: European Radiology
https://www.readbyqxmd.com/read/28950300/frequency-and-angiographic-characteristics-of-coronary-microvascular-dysfunction-in-stable-angina-a-hybrid-imaging-study
#16
Iida Stenström, Teemu Maaniitty, Valtteri Uusitalo, Mikko Pietilä, Heikki Ukkonen, Sami Kajander, Maija Mäki, Jeroen J Bax, Juhani Knuuti, Antti Saraste
Aims: Coronary microvascular dysfunction (CMD) can cause angina in the absence of obstructive coronary artery disease (CAD). We studied the frequency and angiographic characteristics of CMD in symptomatic patients with suspected stable CAD and identified CMD as diffusely abnormal coronary vasodilator capacity by positron emission tomography (PET) perfusion imaging. Methods and results: We recruited prospectively 189 patients with intermediate pre-test probability of CAD who underwent coronary computed tomography angiography and quantitative 15O-water PET perfusion imaging followed by invasive coronary angiography, and assessment of fractional flow reserve when feasible...
November 1, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28948350/diagnostic-accuracy-of-an-artificial-neural-network-compared-with-statistical-quantitation-of-myocardial-perfusion-images-a-japanese-multicenter-study
#17
Kenichi Nakajima, Takashi Kudo, Tomoaki Nakata, Keisuke Kiso, Tokuo Kasai, Yasuyo Taniguchi, Shinro Matsuo, Mitsuru Momose, Masayasu Nakagawa, Masayoshi Sarai, Satoshi Hida, Hirokazu Tanaka, Kunihiko Yokoyama, Koichi Okuda, Lars Edenbrandt
PURPOSE: Artificial neural networks (ANN) might help to diagnose coronary artery disease. This study aimed to determine whether the diagnostic accuracy of an ANN-based diagnostic system and conventional quantitation are comparable. METHODS: The ANN was trained to classify potentially abnormal areas as true or false based on the nuclear cardiology expert interpretation of 1001 gated stress/rest (99m)Tc-MIBI images at 12 hospitals. The diagnostic accuracy of the ANN was compared with 364 expert interpretations that served as the gold standard of abnormality for the validation study...
September 26, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28936780/ct-based-spect-attenuation-correction-and-assessment-of-infarct-size-results-from-a-cardiac-phantom-study
#18
Alexander Stephan Kroiss, Stephan Gerhard Nekolla, Georg Dobrozemsky, Thomas Grubinger, Barry Lynn Shulkin, Markus Schwaiger
RATIONALE: Myocardial perfusion SPECT is a commonly performed, well established, clinically useful procedure for the management of patients with coronary artery disease. However, the attenuation of photons from myocardium impacts the quantification of infarct sizes. CT-Attenuation Correction (AC) potentially resolves this problem. This contention was investigated by analyzing various parameters for infarct size delineation in a cardiac phantom model. METHODS: A thorax phantom with a left ventricle (LV), fillable defects, lungs, spine and liver was used...
September 21, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28920042/mitochondrial-atp-sensitive-potassium-channels-play-a-role-in-reducing-both-myocardial-infarction-and-reperfusion-arrhythmia-in-remote-ischemic-preconditioned-hearts
#19
Young-Ho Jang, June-Hong Kim, Yong-Cheol Lee
BACKGROUND: Mitochondrial ATP-sensitive potassium (mKATP) channels play a role in reperfusion arrhythmias (RAs) in ischemia-reperfusion (I/R) injury. Evidence suggests that remote ischemic preconditioning (RIPC) reduces RAs, however not much is known on the mechanistic role of mKATP in RIPC. We evaluated whether mKATP channels are associated with reducing arrhythmia and infarct size in RIPC. METHODS: Isolated rat hearts received 30 minutes of regional ischemia followed by 2 hours of reperfusion through the Langendorff perfusion system...
February 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/28905206/improved-diagnosis-of-the-number-of-stenosed-coronary-artery-vessels-by-segmentation-with-scatter-and-photo-peak-window-data-for-attenuation-correction-in-myocardial-perfusion-spect
#20
Yohei Yamauchi, Yumiko Kanzaki, Masuo Hayashi, Mami Arai, Hideaki Morita, Tsuyoshi Komori, Masaaki Hoshiga, Nobukazu Ishizaka
BACKGROUND: Attenuation correction using segmentation of scatter and photo-peak window data (SSPAC) enables an evaluation of the attenuation map in a patient-specific manner without additional radiation exposure. We compared the accuracy of SSPAC and non-corrected myocardial perfusion scintigraphy methods for diagnosing the number of stenosed coronary artery vessels. METHODS AND RESULTS: We retrospectively reviewed the data from 183 consecutive patients who underwent (99m)Tc-tetrofosmin stress/rest SPECT examination and a coronary angiography within 3 months...
September 13, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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