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Quantitative myocardial perfusion

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https://www.readbyqxmd.com/read/28526044/clinical-outcomes-meta-analysis-measuring-subendocardial-perfusion-and-efficacy-of-transmyocardial-laser-revascularization-with-nuclear-imaging
#1
REVIEW
Jessika Iwanski, Shannon M Knapp, Ryan Avery, Isabel Oliva, Raymond K Wong, Raymond B Runyan, Zain Khalpey
INTRODUCTION: Randomized and nonrandomized clinical trials have tried to assess whether or not TMR patients experience an increase in myocardial perfusion. However there have been inconsistencies reported in the literature due to the use of different nuclear imaging modalities to test this metric. The primary purpose of this meta-analysis was to determine whether SPECT, MUGA and PET scans demonstrate changes in myocardial perfusion between lased and non-lased subjects and whether laser type affects myocardial perfusion...
May 19, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28523283/variable-temporal-sampling-and-tube-current-modulation-for-myocardial-blood-flow-estimation-from-dose-reduced-dynamic-computed-tomography
#2
Dimple Modgil, Michael D Bindschadler, Adam M Alessio, Patrick J La Rivière
Quantification of myocardial blood flow (MBF) can aid in the diagnosis and treatment of coronary artery disease. However, there are no widely accepted clinical methods for estimating MBF. Dynamic cardiac perfusion computed tomography (CT) holds the promise of providing a quick and easy method to measure MBF quantitatively. However, the need for repeated scans can potentially result in a high patient radiation dose, limiting the clinical acceptance of this approach. In our previous work, we explored techniques to reduce the patient dose by either uniformly reducing the tube current or by uniformly reducing the number of temporal frames in the dynamic CT sequence...
April 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28514327/postoperative-assessment-of-myocardial-function-and-microcirculation-in-patients-with-acute-coronary-syndrome-by-myocardial-contrast-echocardiography
#3
Li Jiang, Hong Yao, Zhao-Guang Liang
BACKGROUND Postoperative myocardial function and microcirculation of acute coronary syndrome (ACS) was assessed by myocardial contrast echocardiography (MCE). MATERIAL AND METHODS Eighty-nine ACS patients treated with percutaneous coronary intervention (PCI) were detected by MCE and two-dimensional ultrasonography before and a month later after PCI respectively. Their myocardial perfusion was evaluated by myocardial contrast score (MSC) and contrast score index (CSI); cross-sectional area of microvessel (A), average myocardial microvascular impairment (β), and myocardial blood flow (MBF) were analyzed by cardiac ultrasound quantitative analysis (CUSQ), and fractional flow reserve (FFR) change was observed...
May 17, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28512722/status-of-cardiovascular-pet-radiation-exposure-and-strategies-for-reduction-an-information-statement-from-the-cardiovascular-pet-task-force
#4
James A Case, Robert A deKemp, Piotr J Slomka, Mark F Smith, Gary V Heller, Manuel D Cerqueira
Cardiovascular positron emission tomography (PET) imaging provides high-quality visual and quantitative myocardial perfusion and function images. In addition, cardiovascular PET can assess myocardial viability, myocardial inflammatory disorders such as cardiac sarcoid, and infections of implanted devices including pacemakers, ventricular assist devices, and prosthetic heart valves. As with all nuclear cardiology procedures, the benefits need to be considered in relation to the risks of exposure to radiation...
May 16, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28504545/detection-of-hemodynamically-significant-coronary-artery-stenosis-with-ct-enhancement-ratio-a-validation-study-in-a-porcine-model
#5
Jun Chen, Yang Pu, Zhang Zhang, Xuefang Yu, Zhengwen Yang
OBJECTIVE: Although numerous techniques that are based on CT number analysis have been proposed, the assessment of hemodynamically significant coronary artery stenosis remains a great challenge. The purpose of this study is to validate use of the CT enhancement ratio in the detection of hemodynamically significant coronary artery stenosis in a porcine model. MATERIALS AND METHODS: Experiments involving eight closed-chest swine were performed. A balloon catheter was placed into the left anterior descending coronary artery to simulate different degrees of luminal stenosis...
May 15, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28501269/peak-enhancement-ratio-of-myocardium-to-aorta-for-identification-of-myocardial-ischemia-using-dynamic-myocardial-computed-tomography-perfusion-imaging
#6
Yuki Tanabe, Teruhito Kido, Akira Kurata, Takahiro Yokoi, Naoki Fukuyama, Teruyoshi Uetani, Hikaru Nishiyama, Naoto Kawaguchi, Enver Tahir, Masao Miyagawa, Teruhito Mochizuki
BACKGROUND: This study aimed to evaluate the feasibility of peak enhancement (PE) ratio of myocardium to aorta (PER) derived from stress dynamic computed tomography myocardial perfusion imaging (CTP) for the detection of myocardial ischemia assessed by magnetic resonance (MR) imaging. METHODS: Forty-four patients who underwent stress dynamic CTP and MR imaging were retrospectively evaluated. From the time-attenuation curve, myocardial PE, PER, and myocardial blood flow (MBF) were calculated on a segment-based analysis...
May 10, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28473616/mini-review-on-cardiac-metabolic-imaging-current-imaging-modalities-and-future-perspectives
#7
Tineke van de Weijer, Elisabeth Helena Maria Paiman, Hildo J Lamb
In this review, current imaging techniques and their future perspectives in the field of cardiac metabolic imaging in humans are discussed. This includes a range of non-invasive imaging techniques allowing a detailed investigation of cardiac metabolism in health and disease. The main imaging modalities discussed are Magnetic Resonance Spectroscopy (MRS) techniques for determination of metabolite content (triglycerides, glucose, ATP, phosphocreatine and so on), MRI (for myocardial perfusion) Single Photon Emession Computed Tomography (SPECT) and Positron Emission Tomography (PET) for quantitation of perfusion and substrate uptake...
May 4, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28473401/ranolazine-in-symptomatic-diabetic-patients-without-obstructive-coronary-artery-disease-impact-on-microvascular-and-diastolic-function
#8
Nishant R Shah, Michael K Cheezum, Vikas Veeranna, Stephen J Horgan, Viviany R Taqueti, Venkatesh L Murthy, Courtney Foster, Jon Hainer, Karla M Daniels, Jose Rivero, Amil M Shah, Peter H Stone, David A Morrow, Michael L Steigner, Sharmila Dorbala, Ron Blankstein, Marcelo F Di Carli
BACKGROUND: Treatments for patients with myocardial ischemia in the absence of angiographic obstructive coronary artery disease are limited. In these patients, particularly those with diabetes mellitus, diffuse coronary atherosclerosis and microvascular dysfunction is a common phenotype and may be accompanied by diastolic dysfunction. Our primary aim was to determine whether ranolazine would quantitatively improve exercise-stimulated myocardial blood flow and cardiac function in symptomatic diabetic patients without obstructive coronary artery disease...
May 4, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28470630/characteristics-of-single-and-dual-photopeak-energy-window-acquisitions-with-thallium-201-iq-spect-ct-system
#9
Takayuki Shibutani, Masahisa Onoguchi, Hiroto Yoneyama, Takahiro Konishi, Shinro Matsuo, Kenichi Nakajima, Seigo Kinuya
OBJECTIVES: Although dual-energy (DE) acquisition with conventional (201)Tl myocardial perfusion SPECT has several advantages such as improved attenuation of the inferior wall and increased acquisition counts, the characteristics of IQ-SPECT have not been fully evaluated. We evaluate the difference of characteristics between single-energy (SE) and dual-energy (DE) imaging using (201)Tl myocardial IQ-SPECT. METHODS: Two myocardial phantoms were created simulating normal myocardium and infarction of the inferior wall...
May 3, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28469688/significance-of-abnormal-myocardial-perfusion-scans-in-candidates-for-orthotopic-liver-transplantation
#10
Atefe Esmaili, Saeed Farzanefar, Alireza Emami-Ardakani, Mehrshad Abbasi
Background: The implications of cardiac risk stratification before orthotopic liver transplantation (OLT) are not well established. We studied the usefulness of myocardial perfusion imaging (MPI) in this scenario. Methods: MPI data of 24 patients (9 females), candidates of OLT, were collected. They underwent MPI as part of their preoperative risk assessment. MPIs were interpreted by 2 nuclear physicians, who had access to clinical data, scan, and semi-quantification results (i.e., quantitative perfusion single-photon emission tomography (SPECT) [QPS] and quantitative gated SPECT [QGS])...
January 2017: Journal of Tehran Heart Center
https://www.readbyqxmd.com/read/28462467/the-effect-of-ct-based-attenuation-correction-on-the-automatic-perfusion-score-of-myocardial-perfusion-imaging-using-a-dedicated-cardiac-solid-state-czt-spect-ct
#11
John A Kennedy, Yafim Brodov, Adam L Weinstein, Ora Israel, Alex Frenkel
BACKGROUND: Data regarding cardiac cadmium-zinc-telluride (CZT)-specific augmented databases and their impact on CT-based attenuation correction (AC) perfusion scores in myocardial perfusion imaging (MPI) were obtained on a multiple-pinhole CZT SPECT/CT. METHODS AND RESULTS: Summed stress (SSS) and rest scores (SRS) were measured using automated software in three independent patient groups: group 1 (n = 80) underwent MPI on both CZT and conventional sodium iodide (NaI) devices, group 2 (n = 80) with low coronary artery disease likelihood and normal MPI provided reference CZT databases; and group 3 (n = 152) served to compare AC and non-AC (NAC) scores on CZT...
May 1, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28453721/apheresis-as-novel-treatment-for-refractory-angina-with-raised-lipoprotein-a-a-randomized-controlled-cross-over-trial
#12
Tina Z Khan, Li-Yueh Hsu, Andrew E Arai, Samantha Rhodes, Alison Pottle, Ricardo Wage, Winston Banya, Peter D Gatehouse, Shivraman Giri, Peter Collins, Dudley J Pennell, Mahmoud Barbir
Aims: To determine the clinical impact of lipoprotein apheresis in patients with refractory angina and raised lipoprotein(a) > 500 mg/L on the primary end point of quantitative myocardial perfusion, as well as secondary end points including atheroma burden, exercise capacity, symptoms, and quality of life. Methods: We conducted a single-blinded randomized controlled trial in 20 patients with refractory angina and raised lipoprotein(a) > 500 mg/L, with 3 months of blinded weekly lipoprotein apheresis or sham, followed by crossover...
April 26, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28439760/prognostic-study-of-cardiac-events-in-japanese-patients-with-chronic-kidney-disease-using-ecg-gated-myocardial-perfusion-imaging-final-3-year-report-of-the-j-access-3-study
#13
Satoko Nakamura, Yuhei Kawano, Kenichi Nakajima, Hiroki Hase, Nobuhiko Joki, Tsuguru Hatta, Shigeyuki Nishimura, Masao Moroi, Susumu Nakagawa, Tokuo Kasai, Hideo Kusuoka, Yasuchika Takeishi, Mitsuru Momose, Kazuya Takehana, Mamoru Nanasato, Syunichi Yoda, Hidetaka Nishina, Naoya Matsumoto, Tsunehiko Nishimura
BACKGROUND: Myocardial perfusion imaging (MPI) is considered useful for risk stratification among patients with chronic kidney disease (CKD), without renal deterioration by contrast media. METHODS AND RESULTS: The Japanese Assessment of Cardiac Events and Survival Study by Quantitative Gated SPECT (J-ACCESS 3) is a multicenter, prospective cohort study investigating the ability of MPI to predict cardiac events in 529 CKD patients without a definitive coronary artery disease...
April 24, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28431062/impact-of-basal-inferolateral-scar-burden-determined-by-automatic-analysis-of-99mtc-mibi-myocardial-perfusion-spect-on-the-long-term-prognosis-of-cardiac-resynchronization-therapy
#14
Itsuro Morishima, Kenji Okumura, Hideyuki Tsuboi, Yasuhiro Morita, Kensuke Takagi, Ruka Yoshida, Hiroaki Nagai, Toshiro Tomomatsu, Yoshihiro Ikai, Kazushi Terada, Takahito Sone, Toyoaki Murohara
Aims: Left-ventricular (LV) scarring may be associated with a poor response to cardiac resynchronization therapy (CRT). The automatic analysis of myocardial perfusion single-photon emission computed tomography (MP-SPECT) may provide objective quantification of LV scarring. We investigated the impact of LV scarring determined by an automatic analysis of MP-SPECT on short-term LV volume response as well as long-term outcome. Methods and Results: We studied consecutive 51 patients who were eligible to undergo 99mTc-MIBI MP-SPECT both at baseline and 6 months after CRT (ischaemic cardiomyopathies 31%)...
April 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28430369/quantitative-segmental-analysis-of-myocardial-perfusion-to-differentiate-stress-cardiomyopathy-from-acute-myocardial-infarction-a-myocardial-contrast-echocardiography-study
#15
Sun-Yang Min, Jong-Min Song, Yewon Shin, Min-Jung Sin, Dae-Hee Kim, Duk-Hyun Kang, Jae-Kwan Song
BACKGROUND: Both stress cardiomyopathy (SCMP) and acute myocardial infarction (AMI) present with similar clinical symptoms and signs, and apical akinesis. HYPOTHESIS: Quantitative segmental analysis of myocardial contrast echocardiography (MCE) helps to differentiate AMI from SCMP. METHODS: Real-time MCE was performed in 33 consecutive patients who presented with an acute symptom/sign and a new apical akinesis on echocardiography. In 18 left ventricular (LV) myocardial segments, a replenishment curve was obtained in each segment to measure peak plateau myocardial contrast intensity (MCI) (A) and the replenishment curve slope (β)...
April 21, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28416358/non-gated-high-pitch-computed-tomography-aortic-angiography-myocardial-perfusion-defects-in-patients-with-suspected-aortic-dissection
#16
Li-Ting Huang, Shih-Hung Chan, Chia-Chang Chuang, Yi-Shan Tsai
OBJECTIVES: To investigate the diagnostic value of first-pass myocardial perfusion defects visualised in non-gated high-pitch computed tomography angiography (CTA) in patients admitted to the emergency department (ED) for suspected aortic dissection. METHODS: We recruited 174 ED patients who underwent high-pitch CTA of the aorta because of suspected aortic dissection. We divided these patients into two groups (diseased and control groups) based on whether their clinical data fulfilled the third universal definition of acute myocardial infarction (AMI), specifically an increase in cardiac troponin (cTn) with at least one of the following: (a) symptoms of ischemia; (b) new ST-segment-T wave (ST-T) changes or new left bundle branch block (LBBB); (c) development of pathological Q wave; (d) new loss of viable myocardium or new regional wall motion abnormality; or (e) identification of an intracoronary thrombus by angiography or autopsy...
April 12, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28391190/4d-reconstruction-with-respiratory-correction-for-gated-myocardial-perfusion-spect
#17
Wenyuan Qi, Yongyi Yang, Chao Song, Miles Wernick, P Hendrik Pretorius, Michael King
Cardiac SPECT images are known to suffer from both cardiac and respiratory motion blur. In this work, we investigate a 4D reconstruction approach to suppress the effect of respiratory motion in gated cardiac SPECT imaging. In this approach, the sequence of cardiac gated images is reconstructed with respect to a reference respiratory amplitude bin in the respiratory cycle. To combat the challenge of inherent high imaging noise, we utilize the data counts acquired during the entire respiratory cycle by making use of a motion-compensated scheme, in which both cardiac motion and respiratory motion are taken into account...
April 4, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28389506/dynamic-computed-tomography-myocardial-perfusion-imaging-comparison-of-clinical-analysis-methods-for-the-detection-of-vessel-specific-ischemia
#18
COMPARATIVE STUDY
Alexia Rossi, Andrew Wragg, Ernst Klotz, Federica Pirro, James C Moon, Koen Nieman, Francesca Pugliese
BACKGROUND: The clinical analysis of myocardial dynamic computed tomography myocardial perfusion imaging lacks standardization. The objective of this prospective study was to compare different analysis approaches to diagnose ischemia in patients with stable angina referred for invasive coronary angiography. METHODS AND RESULTS: Patients referred for evaluation of stable angina symptoms underwent adenosine-stress dynamic computed tomography myocardial perfusion imaging with a second-generation dual-source scanner...
April 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28380247/a-new-ct-reconstruction-technique-using-adaptive-deformation-recovery-and-intensity-correction-adric
#19
You Zhang, Jianhua Ma, Puneeth Iyenga, Yuncheng Zhong, Jing Wang
PURPOSE: Sequential same-patient CT images may involve deformation-induced and non-deformation-induced voxel intensity changes. An adaptive deformation recovery and intensity correction (ADRIC) technique was developed to improve the CT reconstruction accuracy, and to separate deformation from non-deformation-induced voxel intensity changes between sequential CT images. MATERIALS AND METHODS: ADRIC views the new CT volume as a deformation of a prior high-quality CT volume, but with additional non-deformation-induced voxel intensity changes...
April 5, 2017: Medical Physics
https://www.readbyqxmd.com/read/28374328/epicardial-and-microvascular-coronary-vasomotor-dysfunction-and-its-relation-to-myocardial-ischemic-burden-in-patients-with-non-obstructive-coronary-artery-disease
#20
Edoardo Verna, Sergio Ghiringhelli, Stefano Provasoli, Simone Scotti, Jorge Salerno-Uriarte
AIM: To assess the relative contribution of epicardial endothelium-dependent (EDD) and microvascular endothelium-independent (EIMVD) coronary vasomotor dysfunction to the extent of myocardial ischemia in patients with normal angiograms or non-obstructive coronary artery disease (NOCAD). METHODS: Coronary vasomotion was evaluated by quantitative angiography and blood flow (CBF) measurements during intracoronary acetylcholine, nitroglycerine, and adenosine in 101 patients...
April 3, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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