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Quantitative myocardial perfusion

Allison D Ta, Li-Yueh Hsu, Hannah M Conn, Susanne Winkler, Anders M Greve, Sujata M Shanbhag, Marcus Y Chen, W Patricia Bandettini, Andrew E Arai
BACKGROUND: Dark rim artifacts in first-pass cardiovascular magnetic resonance (CMR) perfusion images can mimic perfusion defects and affect diagnostic accuracy for coronary artery disease (CAD). We evaluated whether quantitative myocardial blood flow (MBF) can differentiate dark rim artifacts from true perfusion defects in CMR perfusion. METHODS: Regadenoson perfusion CMR was performed at 1.5 T in 76 patients. Significant CAD was defined by quantitative invasive coronary angiography (QCA) ≥ 50% diameter stenosis...
March 8, 2018: Journal of Cardiovascular Magnetic Resonance
Benjamin Zorach, Peter W Shaw, Jamieson Bourque, Sujith Kuruvilla, Pelbreton C Balfour, Yang Yang, Roshin Mathew, Jonathan Pan, Jorge A Gonzalez, Angela M Taylor, Craig H Meyer, Frederick H Epstein, Christopher M Kramer, Michael Salerno
BACKGROUND: Preliminary semi-quantitative cardiovascular magnetic resonance (CMR) perfusion studies have demonstrated reduced myocardial perfusion reserve (MPR) in patients with angina and risk factors for microvascular disease (MVD), however fully quantitative CMR has not been studied. The purpose of this study is to evaluate whether fully quantitative CMR identifies reduced MPR in this population, and to investigate the relationship between epicardial atherosclerosis, left ventricular hypertrophy (LVH), extracellular volume (ECV), and perfusion...
February 22, 2018: Journal of Cardiovascular Magnetic Resonance
Agnieszka Żyromska, Bogdan Małkowski, Tomasz Wiśniewski, Karolina Majewska, Joanna Reszke, Roman Makarewicz
OBJECTIVE: Studies examining radiation-induced heart toxicity in breast cancer patients are inconclusive. The aim of this study was to prospectively and quantitatively asses myocardial blood flow (MBF) with, for the first time, 15O-H2O PET/CT as a marker of heart damage in irradiated breast cancer patients. METHODS: Fifteen breast cancer patients receiving intact breast or chest wall irradiation were included in the analysis (six with right-sided and nine with left-sided breast cancer)...
February 22, 2018: British Journal of Radiology
Li-Yueh Hsu, Matthew Jacobs, Mitchel Benovoy, Allison D Ta, Hannah M Conn, Susanne Winkler, Anders M Greve, Marcus Y Chen, Sujata M Shanbhag, W Patricia Bandettini, Andrew E Arai
OBJECTIVES: The authors developed a fully automated framework to quantify myocardial blood flow (MBF) from contrast-enhanced cardiac magnetic resonance (CMR) perfusion imaging and evaluated its diagnostic performance in patients. BACKGROUND: Fully quantitative CMR perfusion pixel maps were previously validated with microsphere MBF measurements and showed potential in clinical applications, but the methods required laborious manual processes and were excessively time-consuming...
February 9, 2018: JACC. Cardiovascular Imaging
Mohsen Qutbi, Mehdi Soltanshahi, Mojtaba Ansari, Hoda Hashemi, Isa Neshandar Asli, Babak Shafiei
Dextrocardia, although a rare cardiac abnormality, carries the same risk for cardiac events as other people. SPECT Myocardial perfusion imaging is a potentially helpful diagnostic tool in patients with dextrocardia. Because of swapping of lateral and septal walls on SPECT slices, although visual analysis is possible, quantitation is substantially limited. Here, we introduce a simple practical method to make quantitative analysis feasible and accurate.
2018: Nuclear Medicine Review. Central & Eastern Europe
Preeti Singh, Bhairavi Bhatt, Shwetal U Pawar, Ashish Kamra, Suruchi Shetye, Mangala Ghorpade
Purpose: Ischemic cardiomyopathy (ICM) and non-ICM (NICM) causes of dilated cardiomyopathy with similar clinical presentation have different management and prognosis. This study employed myocardial perfusion imaging (MPI) to differentiate between the two using quantitative parameters in Indian population. Methods and Materials: Fifty patients prospectively underwent MPI and18 F-fluorodeoxyglucose metabolism studies. P values (0.05 as significant) were calculated for the left ventricular ejection fraction (EF), end diastolic volume (EDV) at rest and stress, end systolic volume (ESV) at rest and stress, summed rest score (SRS), summed difference score (SDS), and eccentricity...
January 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
Dharmender Malik, Ashwani Sood, Madan Parmar, Bhagwant Rai Mittal
Background: Phase analysis can be easily performed by different software to assess the left ventricular dyssynchrony from gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) with high precision. However, the normal values of histogram bandwidth (HBW) and phase standard deviation (PSD) and their comparison using different programs have not been fully elucidated and actively being evaluated at present. The aim of this study was to determine the phase analysis parameters values and to compare the phase indices of two commonly used programs in a group of patients with normal gated SPECT-MPI...
January 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
Hailey A Houson, Gregory N Nkepang, Andria F Hedrick, Vibhudutta Awasthi
Positron emission tomography (PET) of myocardial infarction (MI) by infarct avid imaging has the potential to reduce the time to diagnosis and improve diagnostic accuracy. The objective of this work was to synthesize 18 F-labeled glucaric acid (FGA) for PET imaging of isoproterenol-induced cardiomyopathy in a rat model. METHODS: We synthesized 18 F-FGA by controlled oxidation of 18 F-fluorodeoxy glucose (FDG), mediated by 4-acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO) in presence of NaBr and NaOCl in highly-buffered reaction conditions...
December 27, 2017: Nuclear Medicine and Biology
Roel S Driessen, Wijnand J Stuijfzand, Pieter G Raijmakers, Ibrahim Danad, James K Min, Jonathon A Leipsic, Amir Ahmadi, Jagat Narula, Peter M van de Ven, Marc C Huisman, Adriaan A Lammertsma, Albert C van Rossum, Niels van Royen, Paul Knaapen
BACKGROUND: Atherosclerotic plaque characteristics may affect downstream myocardial perfusion, as well as coronary lesion severity. OBJECTIVES: This study sought to evaluate the association between quantitative plaque burden and plaque morphology obtained using coronary computed tomography angiography (CTA) and quantitative myocardial perfusion obtained using [15 O]H2 O positron emission tomography (PET), as well as fractional flow reserve (FFR) derived invasively...
February 6, 2018: Journal of the American College of Cardiology
Denise Mayumi Tanaka, Luciano Fonseca Lemos de Oliveira, José Antônio Marin-Neto, Minna Moreira Dias Romano, Eduardo Elias Vieira de Carvalho, Antonio Carlos Leite de Barros Filho, Fernando Fonseca França Ribeiro, Jorge Mejia Cabeza, Carla Duque Lopes, Camila Godoy Fabricio, Norival Kesper, Henrique Turin Moreira, Lauro Wichert-Ana, André Schmidt, Maria de Lourdes Higuchi, Edécio Cunha-Neto, Marcus Vinícius Simões
BACKGROUND: Myocardial perfusion defects (MPD) due to coronary microvascular dysfunction is frequent in chronic Chagas cardiomyopathy (CCC) and may be involved with development of myocardial damage. We investigated whether MPD precedes left ventricular systolic dysfunction and tested the hypothesis that prolonged use of dipyridamole (DIPY) could reduce MPD in an experimental model of CCC in hamsters. METHODS AND RESULTS: We investigated female hamsters 6-months after T...
February 1, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Constantine Zakkaroff, John D Biglands, John P Greenwood, Sven Plein, Roger D Boyle, Aleksandra Radjenovic, Derek R Magee
Myocardial perfusion imaging, coupled with quantitative perfusion analysis, provides an important diagnostic tool for the identification of ischaemic heart disease caused by coronary stenoses. The accurate mapping between coronary anatomy and under-perfused areas of the myocardium is important for diagnosis and treatment. However, in the absence of the actual coronary anatomy during the reporting of perfusion images, areas of ischaemia are allocated to a coronary territory based on a population-derived 17-segment (American Heart Association) AHA model of coronary blood supply...
2018: Computer Methods in Biomechanics and Biomedical Engineering. Imaging & Visualization
Brandon A Howard, Lance Roy, Alan David Kaye, Srinivas Pyati
PURPOSE OF REVIEW: To describe the current understanding of the role of three-phase bone scintigraphy (TPBS) in the diagnosis and management of complex regional pain syndrome (CRPS), discuss its advantages and limitations, and present three examples of TPBS patterns typically seen in CRPS patients. RECENT FINDINGS: CRPS is a debilitating disorder frequently presenting with pain to ordinarily non-painful stimuli, redness, swelling, following fractures, stroke, myocardial infarction, surgery, or even minor trauma, and its diagnosis, based on clinical criteria and supportive imaging findings, is difficult...
February 1, 2018: Current Pain and Headache Reports
Polyxeni Gkontra, Kerri-Ann Norton, Magdalena M Żak, Cristina Clemente, Jaume Agüero, Borja Ibáñez, Andrés Santos, Aleksander S Popel, Alicia G Arroyo
The microvasculature continuously adapts in response to pathophysiological conditions to meet tissue demands. Quantitative assessment of the dynamic changes in the coronary microvasculature is therefore crucial in enhancing our knowledge regarding the impact of cardiovascular diseases in tissue perfusion and in developing efficient angiotherapies. Using confocal microscopy and thick tissue sections, we developed a 3D fully automated pipeline that allows to precisely reconstruct the microvasculature and to extract parameters that quantify all its major features, its relation to smooth muscle actin positive cells and capillary diffusion regions...
January 30, 2018: Scientific Reports
Tom Gyllenhammar, Mikael Kanski, Henrik Engblom, Dirk M Wuttge, Marcus Carlsson, Roger Hesselstrand, Håkan Arheden
BACKGROUND: Patients with systemic sclerosis (SSc) have high cardiovascular mortality even though there is no or little increase in prevalence of epicardial coronary stenosis. First-pass perfusion on cardiovascular magnetic resonance (CMR) have detected perfusion defects indicative of microvascular disease, but the quantitative extent of hypoperfusion is not known. Therefore, we aimed to determine if patients with SSc have lower global myocardial perfusion (MP) at rest or during adenosine stress, compared to healthy controls, quantified with CMR...
January 30, 2018: BMC Cardiovascular Disorders
Wenhui Yang, Yan He, Lulu Gan, Fan Zhang, Baotong Hua, Ping Yang, Juan Liu, Li Yang, Tao Guo
Cardiac Shock Wave Therapy (CSWT) improves myocardial perfusion and ameliorates cardiac remodeling after acute myocardial infarction (AMI), but the precise mechanisms remain obscure. Herein, we have applied CSWT to a rat model of AMI to demonstrate the arteriogenesis of coronary micrangium and protein expression changes in ischemic myocardium after CSWT. Four weeks after CSWT, the fraction shortening of rats was improved greatly and the cardiomyocyte apoptosis index was significantly lower than the AMI group (P < 0...
January 29, 2018: Scientific Reports
Emilia Zampella, Wanda Acampa, Roberta Assante, Carmela Nappi, Valeria Gaudieri, Ciro Gabriele Mainolfi, Roberta Green, Valeria Cantoni, Mariarosaria Panico, Michele Klain, Mario Petretta, Piotr J Slomka, Alberto Cuocolo
PURPOSE: Cardiac imaging with PET/CT allows measurement of coronary artery calcium (CAC), myocardial perfusion and coronary vascular function. We investigated whether the combined assessment of regional CAC score, ischemic total perfusion deficit (ITPD) and quantitative coronary vascular function would further improve the diagnostic accuracy of PET/CT in predicting obstructive coronary artery disease (CAD). METHODS: We analyzed 113 patients with suspected CAD referred to 82Rb PET/CT myocardial perfusion imaging with available coronary angiographic data...
January 25, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Alessia Peli, Luca Camoni, Valentina Zilioli, Rexhep Durmo, Mattia Bonacina, Francesco Bertagna, Barbara Paghera, Raffaele Giubbini
BACKGROUND: Myocardial perfusion imaging is a well-established diagnostic tool in patients with known or suspected coronary artery disease. Numerous clinical trials have shown that attenuation correction (AC) in single photon emission computed tomography (SPECT) improves the diagnostic accuracy of myocardial perfusion imaging over non-AC SPECT, differentiating between scar and attenuation artifacts. We have previously shown that attenuation artifacts produce an overestimation of the size of inferior infarcts in the male population...
January 22, 2018: Nuclear Medicine Communications
Hiroshi Wakabayashi, Junichi Taki, Anri Inaki, Tomo Hiromasa, Koichi Okuda, Takayuki Shibutani, Kazuhiro Shiba, Seigo Kinuya
PURPOSE: Ultra-high resolution single-photon emission computed tomography (SPECT) system, using multiple pinhole collimators, has been applied to the imaging of small rodents. We aimed to compare the myocardial infarction (MI) area on quantitative perfusion single-photon emission computed tomography (QPS; Cedars-Sinai Medical Center, USA) with that on high-resolution autoradiography in rat model to determine the accuracy of perfusion defect measurement by QPS. PROCEDURES: After thoracotomy, rats (n = 9) had their left coronary arteries occluded and reperfused before injection with 185 MBq [99mTc] methoxyisobutylisonitrile ([99mTc]MIBI) for SPECT and autoradiography...
January 16, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Mohammad Taghi Bahreyni-Toossi, Habibeh Vosoughi, Hosein Azimian, Abdul Rahim Rezaei, Mehdi Momennezhad
Objectives: In recent years, the application of radiopharmaceuticals in nuclear medicine has increased substantially. Following the diagnostic procedures performed in nuclear medicine departments, such as myocardial perfusion imaging, patients generally receive considerable doses of radiation. Normally, radiation-induced DNA damages are expected following exposure to a low-dose ionizing radiation. In order to detect molecular changes, high-sensitivity techniques must be utilized. The aim of this study was to assess the effect of a low-dose (below 10 mSv) gamma ray on gene expression using quantitative real-time polymerase chain reaction (qRT-PCR)...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
Anil Kumar Avs, P G Kumar, Ajay Swami, Yiteedra Dinker
BACKGROUND: After a primary transluminal coronary angioplasty (PTCA) following AMI (acute myocardial infarction), the perfusion defect and LV (left ventricular) function recover/change over a period of time. The analysis immediately after the procedure may not be true depiction of the exact success of the procedure. There is varying and scanty information available on the natural course of changes in these parameters after a successful PTCA. We hypothesized that majority of change occurs at 3-4 month period...
January 10, 2018: Nuclear Medicine Review. Central & Eastern Europe
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