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Quantitative myocardial perfusion

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https://www.readbyqxmd.com/read/29340889/quantification-of-myocardial-perfusion-defect-size-in-rats-comparison-between-quantitative-perfusion-spect-and-autoradiography
#1
Hiroshi Wakabayashi, Junichi Taki, Anri Inaki, Tomo Hiromasa, Koichi Okuda, Takayuki Shibutani, Kazuhiro Shiba, Seigo Kinuya
PURPOSE: Ultra-high resolution single-photon emission computed tomography (SPECT) system, using multiple pinhole collimators, has been applied to the imaging of small rodents. We aimed to compare the myocardial infarction (MI) area on quantitative perfusion single-photon emission computed tomography (QPS; Cedars-Sinai Medical Center, USA) with that on high-resolution autoradiography in rat model to determine the accuracy of perfusion defect measurement by QPS. PROCEDURES: After thoracotomy, rats (n = 9) had their left coronary arteries occluded and reperfused before injection with 185 MBq [99mTc] methoxyisobutylisonitrile ([99mTc]MIBI) for SPECT and autoradiography...
January 16, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29333465/in-vivo-exposure-effects-of-99mtc-methoxyisobutylisonitrile-on-the-fdxr-and-xpa-genes-expression-in-human-peripheral-blood-lymphocytes
#2
Mohammad Taghi Bahreyni-Toossi, Habibeh Vosoughi, Hosein Azimian, Abdul Rahim Rezaei, Mehdi Momennezhad
Objectives: In recent years, the application of radiopharmaceuticals in nuclear medicine has increased substantially. Following the diagnostic procedures performed in nuclear medicine departments, such as myocardial perfusion imaging, patients generally receive considerable doses of radiation. Normally, radiation-induced DNA damages are expected following exposure to a low-dose ionizing radiation. In order to detect molecular changes, high-sensitivity techniques must be utilized. The aim of this study was to assess the effect of a low-dose (below 10 mSv) gamma ray on gene expression using quantitative real-time polymerase chain reaction (qRT-PCR)...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/29319132/evaluation-of-changes-in-perfusion-defect-and-left-ventricular-systolic-function-using-tc-99m-tetrofosmin-single-photon-emission-computed-tomography-over-3-month-period-in-patients-of-acute-myocardial-infarction-undergoing-primary-angioplasty
#3
Anil Kumar Avs, P G Kumar, Ajay Swami, Yiteedra Dinker
BACKGROUND: After a primary transluminal coronary angioplasty (PTCA) following AMI (acute myocardial infarction), the perfusion defect and LV (left ventricular) function recover/change over a period of time. The analysis immediately after the procedure may not be true depiction of the exact success of the procedure. There is varying and scanty information available on the natural course of changes in these parameters after a successful PTCA. We hypothesized that majority of change occurs at 3-4 month period...
January 10, 2018: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/29317133/ability-of-the-prognostic-model-of-j-access-study-to-predict-cardiac-events-in-a-clinical-setting-the-approach-study
#4
Isao Aburadani, Kazuo Usuda, Hisashi Sumiya, Satoru Sakagami, Hiroaki Kiyokawa, Shinro Matsuo, Masayuki Takamura, Hisayoshi Murai, Shinichiro Takashima, Teppei Kitano, Koichi Okuda, Kenichi Nakajima
BACKGROUND: In patients with coronary artery disease (CAD), one of the risk models available in Japan was a multivariate risk prediction model based on a Japanese multicenter database: the Japanese Assessment of Cardiac Events and Survival Study by Quantitative Gated SPECT (J-ACCESS). The aim of this study was to clinically validate the accuracy of this risk model. METHODS: We evaluated the performance of the J-ACCESS model using data derived from the Assessment of the Predicted value of PROgnosis of cArdiaC events in Hokuriku (APPROACH) registry...
January 6, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29249347/enhancement-of-dynamic-myocardial-perfusion-pet-images-based-on-low-rank-plus-sparse-decomposition
#5
Lijun Lu, Xiaomian Ma, Hassan Mohy-Ud-Din, Jianhua Ma, Qianjin Feng, Arman Rahmim, Wufan Chen
BACKGROUND AND OBJECTIVE: The absolute quantification of dynamic myocardial perfusion (MP) PET imaging is challenged by the limited spatial resolution of individual frame images due to division of the data into shorter frames. This study aims to develop a method for restoration and enhancement of dynamic PET images. METHODS: We propose that the image restoration model should be based on multiple constraints rather than a single constraint, given the fact that the image characteristic is hardly described by a single constraint alone...
February 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29236988/diagnostic-and-prognostic-value-of-myocardial-blood-flow-quantification-as-non-invasive-indicator-of-cardiac-allograft-vasculopathy
#6
Paco E Bravo, Brian A Bergmark, Tomas Vita, Viviany R Taqueti, Ankur Gupta, Sara Seidelmann, Thomas E Christensen, Michael T Osborne, Nishant R Shah, Nina Ghosh, Jon Hainer, Courtney F Bibbo, Meagan Harrington, Fred Costantino, Mandeep R Mehra, Sharmila Dorbala, Ron Blankstein, Akshay Desai, Lynne Stevenson, Michael M Givertz, Marcelo F Di Carli
Aims: Cardiac allograft vasculopathy (CAV) is a leading cause of death in orthotopic heart transplant (OHT) survivors. Effective non-invasive screening methods are needed. Our aim was to investigate the added diagnostic and prognostic value of myocardial blood flow (MBF) to standard myocardial perfusion imaging (MPI) with positron emission tomography (PET) for CAV detection. Methods and results: We studied 94 OHT recipients (prognostic cohort), including 66 who underwent invasive coronary angiography and PET within 1 year (diagnostic cohort)...
December 8, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29232024/myocardial-perfusion-reserve-index-in-children-with-kawasaki-disease
#7
Richard M Friesen, Michal Schäfer, Pei-Ni Jone, Nana Appiawiah, Daniel Vargas, Brian Fonseca, Michael V DiMaria, Uyen Truong, LaDonna Malone, Lorna P Browne
BACKGROUND: Coronary artery lesions in patients with Kawasaki disease (KD) can impair myocardial perfusion, yet evaluation of perfusion defects by cardiac magnetic resonance (MR) in children is often qualitative. PURPOSE: In this study we aimed to use a quantitative method of myocardial perfusion using stress cardiac MR-derived myocardial perfusion reserve index (MPRI) in children with KD and compare MPRI with ventricular mechanical performance evaluated by cardiac MR strain analysis...
December 12, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29230607/the-effect-of-high-count-rates-on-cardiac-perfusion-quantification-in-a-simultaneous-pet-mr-system-using-a-cardiac-perfusion-phantom
#8
Jim O' Doherty, Zacharias Chalampalakis, Paul Schleyer, Muhummad Sohaib Nazir, Amedeo Chiribiri, Paul K Marsden
BACKGROUND: PET-MRI is under investigation as a new strategy for quantitative myocardial perfusion imaging. Consideration is required as to the maximum scanner count rate in order to limit dead-time losses resulting from administered activity in the scanner field of view during the first pass of the radiotracer. RESULTS: We performed a decaying-source experiment to investigate the high count-rate performance of a PET-MR system (Siemens mMR) over the expected range of activities during a clinical study...
December 11, 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/29223511/ultra-low-dose-quantitative-ct-myocardial-perfusion-imaging-with-sparse-view-dynamic-acquisition-and-image-reconstruction-a-feasibility-study
#9
Esmaeil Enjilela, Ting-Yim Lee, Jiang Hsieh, Gerald Wisenberg, Patrick Teefy, Andrew Yadegari, Rodrigo Bagur, Ali Islam, Kelley Branch, Aaron So
PURPOSE: We implemented and validated a compressed sensing (CS) based algorithm for reconstructing dynamic contrast-enhanced (DCE) CT images of the heart from sparsely sampled X-ray projections. METHODS: DCE CT imaging of the heart was performed on five normal and ischemic pigs after contrast injection. DCE images were reconstructed with filtered backprojection (FBP) and CS from all projections (984-view) and 1/3 of all projections (328-view), and with CS from 1/4 of all projections (246-view)...
November 16, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29216309/coronary-to-pulmonary-artery-fistula-in-adults-evaluation-with-thallium-201-myocardial-perfusion-spect
#10
Seul Ki Lee, Jung Im Jung, Joo Hyun O, Hwan Wook Kim, Ho Joong Youn
OBJECTIVES: With the increasing use of multi-detector CT, the number of detected cases with coronary-to-pulmonary artery fistula (CPAF) has increased. Several previous studies reported severe cases of angina, but no appropriate tests to evaluate myocardial perfusion for patients with CPAF have been established. We evaluated the hemodynamic characteristics of CPAF using thallium-201 (Tl-201) single photon emission computed tomography (SPECT). MATERIALS AND METHODS: Tl-201 SPECT was performed in 17 patients with CPAF, but without evidence of coronary artery disease on coronary computed tomography angiography (CCTA) (age, 58...
2017: PloS One
https://www.readbyqxmd.com/read/29209997/-18f-bms-747158-02pet-imaging-for-evaluating-hepatic-mitochondrial-complex-1dysfunction-in-a-mouse-model-of-non-alcoholic-fatty-liver-disease
#11
Takemi Rokugawa, Sotaro Momosaki, Miwa Ito, Hitoshi Iimori, Yuki Kato, Kohji Abe
BACKGROUND: Mitochondrial dysfunction is one of the main causes of non-alcohol fatty liver disease (NAFLD). [18F]-BMS-747158-02 (18F-BMS) which was originally developed as a myocardial perfusion imaging agent was reported to bind mitochondrial complex-1 (MC-1). The aim of this study was to investigate the potential use of 18F-BMS for evaluating hepatic MC-1 activity in mice fed a methionine- and choline-deficient (MCD) diet. Male C57BL/6J mice were fed a MCD diet for up to 2 weeks. PET scans with 18F-BMS were performed after 1 and 2 weeks of the MCD diet...
December 6, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/29209777/effects-of-aortic-tortuosity-on-left-ventricular-diastolic-parameters-derived-from-gated-myocardial-perfusion-single-photon-emission-computed-tomography-in-patients-with-normal-myocardial-perfusion
#12
Satoshi Kurisu, Kazuhiro Nitta, Yoji Sumimoto, Hiroki Ikenaga, Ken Ishibashi, Yukihiro Fukuda, Yasuki Kihara
Aortic tortuosity is often found on chest radiograph, especially in aged patients. We tested the hypothesis that aortic tortuosity was associated with LV diastolic parameters derived from gated SPECT in patients with normal myocardial perfusion. One-hundred and twenty-two patients with preserved LV ejection fraction and normal myocardial perfusion were enrolled. Descending aortic deviation was defined as the horizontal distance from the left line of the aortic knob to the most prominent left line of the descending aorta...
December 5, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29196789/prediction-of-functional-recovery-after-primary-pci-using-the-estimate-of-myocardial-salvage-in-gated-spect-early-after-acute-myocardial-infarction
#13
Raffaella Calabretta, Angelo Castello, Flavia Linguanti, Francesca Tutino, Alfonso Ciaccio, Cristina Giglioli, Roberto Sciagrà
PURPOSE: Primary percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) aims to achieve myocardial salvage (MS). Because the reference method for measuring MS requires myocardial perfusion imaging (MPI) after tracer injection before PCI, alternative approaches have been proposed, but none has gained wide acceptance. Gated SPECT MPI can assess infarct size (IS), but can also show myocardial stunning. Thus, we compared functional and perfusion abnormalities early after AMI to estimate MS, and to predict left ventricular ejection fraction (LVEF) recovery at follow-up...
December 1, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29178905/diagnostic-performance-of-semi-quantitative-and-quantitative-stress-cmr-perfusion-analysis-a-meta-analysis
#14
REVIEW
R van Dijk, M van Assen, R Vliegenthart, G H de Bock, P van der Harst, M Oudkerk
BACKGROUND: Stress cardiovascular magnetic resonance (CMR) perfusion imaging is a promising modality for the evaluation of coronary artery disease (CAD) due to high spatial resolution and absence of radiation. Semi-quantitative and quantitative analysis of CMR perfusion are based on signal-intensity curves produced during the first-pass of gadolinium contrast. Multiple semi-quantitative and quantitative parameters have been introduced. Diagnostic performance of these parameters varies extensively among studies and standardized protocols are lacking...
November 27, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29177254/semi-quantitative-assessment-of-pulmonary-arterial-hypertension-associated-with-congenital-heart-disease-through-myocardial-perfusion-imaging
#15
Mei Liu, Chunxia Qin, Xiaotian Xia, Mengting Li, Yichun Wang, Lijun Wang, Xiaoke Shang, Xiaoli Lan
OBJECTIVE: The study aimed to use myocardial perfusion imaging (MPI) as a semi-quantitative method to assess the clinical severity of pulmonary arterial hypertension (PAH) in patients with congenital heart disease (CHD). SUBJECTS AND METHODS: A total of 24 patients with PAH related to CHD (PAH-CHD) who received interventional or medical treatment were included. All patients underwent physical examination, cardiac function evaluation, biochemical test, echocardiography, right heart catheterization (RHC), and MPI with 99mTc-methoxyisobutyl isonitrile (99mTc-MIBI) pre and 6 months post treatments...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29168158/assessment-of-attenuation-correction-for-myocardial-pet-imaging-using-combined-pet-mri
#16
Martin Lyngby Lassen, Sazan Rasul, Dietrich Beitzke, Marie-Elisabeth Stelzmüller, Jacobo Cal-Gonzalez, Marcus Hacker, Thomas Beyer
OBJECTIVE: To evaluate the frequency of artifacts in MR-based attenuation correction (AC) maps and their impact on the quantitative accuracy of PET-based flow and metabolism measurements in a cohort of consecutive heart failure patients undergoing combined PET/MR imaging. METHODS: Myocardial viability studies were performed in 20 patients following a dual-tracer protocol involving the assessment of myocardial perfusion ((13)N-NH3: 813 ± 86 MBq) and metabolism ((18)F-FDG: 335 ± 38 MBq)...
November 22, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29153572/prognostic-value-of-quantitative-stress-perfusion-cardiac-magnetic-resonance
#17
Eva C Sammut, Adriana D M Villa, Gabriella Di Giovine, Luke Dancy, Filippo Bosio, Thomas Gibbs, Swarna Jeyabraba, Susanne Schwenke, Steven E Williams, Michael Marber, Khaled Alfakih, Tevfik F Ismail, Reza Razavi, Amedeo Chiribiri
OBJECTIVES: This study sought to evaluate the prognostic usefulness of visual and quantitative perfusion cardiac magnetic resonance (CMR) ischemic burden in an unselected group of patients and to assess the validity of consensus-based ischemic burden thresholds extrapolated from nuclear studies. BACKGROUND: There are limited data on the prognostic value of assessing myocardial ischemic burden by CMR, and there are none using quantitative perfusion analysis. METHODS: Patients with suspected coronary artery disease referred for adenosine-stress perfusion CMR were included (n = 395; 70% male; age 58 ± 13 years)...
November 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29131283/quantitative-myocardial-blush-score-qube-allows-the-prediction-of-heart-failure-development-in-long-term-follow-up-in-patients-with-st-elevation-myocardial-infarction-proof-of-concept-study
#18
Andrzej Tomasik, Tomasz Młyńczak, Edyta Nowak, Katarzyna Pigoń, Artur Iwasieczko, Mariusz Opara, Ewa Nowalany-Kozielska
BACKGROUND: Acute myocardial infarction (AMI) might lead to left ventricular remodeling. Adequate myocardial perfusion is critical to prevent this adverse remodeling. Quantitative myocardial blush evaluator (QuBE) software, available on-line, is a simple analysis tool which enables the precise quantification of myocardial perfusion in the infarct area immediately after interventional treatment. The aim of this study was to assess whether the results of QuBE analysis might predict the development of HF in AMI patients in 3 year-long follow-up...
November 13, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/29127239/a-novel-method-for-quantitative-myocardial-contrast-echocardiography-in-mice
#19
Erika Alvarez, Nancy D Dalton, Yusu Gu, Dan Smith, Alice Luong, Masahiko Hoshijima, Kirk L Peterson, Joshua Rychak
The small size of the mouse heart frequently imparts technical challenges when applying conventional in vivo imaging methods for assessing heart function. Here we describe the use of high frequency ultrasound imaging in conjunction with a size-tuned blood pool contrast agent for quantitatively assessing myocardial perfusion in living mice. A perflurocarbon microbubble formulation exhibiting a narrow size distribution was developed, and echogenicity assessed at 18 MHz in vitro. Adult mice were subjected to permanent ligation of the left anterior descending artery...
November 10, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29118884/breast-arterial-calcifications-on-mammography-do-not-predict-myocardial-ischemia-on-myocardial-perfusion-single-photon-emission-computed-tomography
#20
Ahmed Fathala, Salma Salem, Fahad Alanazi, Deema Abunayyan, Abdelmoneim M Eldali, Abdulaziz Alsugair
Background: The aim of this study was to determine if breast arterial calcification (BAC) on mammography predicts myocardial ischemia (MI) on stress myocardial perfusion single-photon emission computed tomography (MPS). BAC is a type of medial artery calcification that can be seen incidentally on mammography, but the relationship between coronary artery calcification and MI on MPS is yet unknown. Methods: A total of 435 consecutive women underwent mammography and stress MPS within 1 year of each other...
October 2017: Cardiology Research
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