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Quantitative myocardial perfusion

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https://www.readbyqxmd.com/read/27914006/accurate-myocardial-blood-flow-measurements-quality-from-start-to-finish-is-key-to-success
#1
EDITORIAL
James Case
Overall repeatability and accuracy of myocardial blood flow measurements depend on the quality of the image data, the proper use of the quantitative software, and the training of clinical staff. Unlike most imaging tests, absolute blood flow measurements have the potential to provide accurate information beyond what is seen visually. This additive information has been shown to help identify multivessel disease, balanced ischemia, true normal studies, and quality control problems that may not be visible in the relative perfusion pattern...
December 2, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27908505/diagnostic-advantage-of-stress-computed-tomography-myocardial-perfusion-over-single-photon-emission-computed-tomography-for-the-assessment-of-myocardial-ischemia
#2
Yasushi Ueki, Atsushi Izawa, Daisuke Kashiwagi, Shigeki Nishiyama, Shinichi Aso, Chihiro Suzuki, Shumpei Sakurai, Kazuhiro Oguchi, Yoshikazu Yazaki, Uichi Ikeda, Koichiro Kuwahara
BACKGROUND: This study compared adenosine stress computed tomography myocardial perfusion (CTP) with single-photon emission computed tomography (SPECT) in the diagnosis of functionally significant coronary artery stenosis using fractional flow reserve (FFR) as reference standard. METHODS: We included a total of 93 coronary arteries from 31 patients in whom at least one vessel with ≥50% stenosis was detected with computed tomography coronary angiography. All patients underwent both SPECT and adenosine stress CTP, followed by invasive coronary angiography (ICA) and FFR...
November 28, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/27873167/myocardial-perfusion-and-left-ventricular-quantitative-parameters-obtained-using-gated-myocardial-spect-comparison-of-three-software-packages
#3
Sotiria Alexiou, Panagiotis Georgoulias, George Angelidis, Varvara Valotassiou, Ioannis Tsougos, Dimitrios Psimadas, Velissarios Lakiotis, Agaristi Kaspiri, Dimitrios Alexopoulos, Dimitrios Apostolopoulos, Pavlos Vassilakos
BACKGROUND: The aim of the present study was to compare Emory Cardiac Toolbox, Myovation, and Quantitative Gated SPECT software regarding the automatic measurements of perfusion and functional left ventricular (LV) quantitative parameters, summed stress score (SSS), perfusion defect score, LV ejection fraction (LVEF), end-diastolic volume, and end-systolic volume (ESV). METHODS AND RESULTS: (99)mTc-tetrofosmin gated SPECT studies were performed in 634 consecutive patients based on the one-day stress/rest protocol...
November 21, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27855349/comparison-of-rest-and-adenosine-stress-quantitative-and-semi-quantitative-myocardial-perfusion-using-magnetic-resonance-in-patients-with-ischemic-heart-disease
#4
Abbas A Qayyum, Faiza Qayyum, Henrik Bw Larsson, Andreas Kjaer, Philip Hasbak, Niels G Vejlstrup, Jens Kastrup
The aim was to compare absolute quantified myocardial perfusion (MP) to semi-quantitative measurements of MP using MRI for detection of ischemia. Twenty-nine patients underwent rest and stress MP imaging obtained by 1.5T MRI and analyzed using own developed software and by commercial available software. Linear regression analysis demonstrated that absolute quantitative data correlated stronger to maxSI (rest: r=0.296, p=.193; stress: r=0.583, p=0.011; myocardial perfusion reserve (MPR): r=0.789, p<0.001; and Δ myocardial blood flow (Δ MBF: r=0...
November 5, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27834038/artifacts-in-quantitative-analysis-of-myocardial-perfusion-spect-using-cedars-sinai-qps-software
#5
Hadi Malek, Nahid Yaghoobi, Raheleh Hedayati
Quantitative analysis of myocardial perfusion Single photon emission computerized tomography (SPECT) images is increasingly applied in modern nuclear cardiology practice, assisting in the interpretation of myocardial perfusion images (MPI). There are different extensively validated state-of-the-art software packages, including QPS (cedars-Sinai), Corridor 4DM (University of Michigan) and Emory cardiac toolbox (Emory university), providing highly accurate and reproducible data. However, these software packages may suffer from potential artifacts related to patient or technical factors...
November 10, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27832419/temporal-averaging-for-analysis-of-four-dimensional-whole-heart-computed-tomography-perfusion-of-the-myocardium-proof-of-concept-study
#6
S Feger, A Shaban, S Lukas, C Kendziorra, M Rief, E Zimmermann, M Dewey
To assess the feasibility of four-dimensional (4D) whole-heart computed tomography perfusion (CTP) of the myocardium and the added value of temporal averaging of consecutive 3D datasets from different heartbeats for analysis. We included 30 patients with suspected or known coronary artery disease (CAD) who underwent 320-row coronary CT angiography (CTA) and myocardial CTP. Out of these, 15 patients underwent magnetic resonance myocardial perfusion imaging (MR MPI). All CTP examinations were initiated after 3 min of intravenous infusion of adenosine (140 µg/kg/min) and were performed dynamically covering the entire heart every heart beat over a period of 20 ± 3 heart beats...
November 10, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27811121/automatic-valve-plane-localization-in-myocardial-perfusion-spect-ct-by-machine-learning-anatomical-and-clinical-validation
#7
Julian Betancur, Mathieu Rubeaux, Tobias Fuchs, Yuka Otaki, Yoav Arnson, Leandro Slipczuk, Dominik Benz, Guido Germano, Damini Dey, Chih-Jen Lin, Daniel Berman, Philipp Kaufmann, Piotr Slomka
: Precise definition of the mitral valve plane (VP) during segmentation of the left ventricle (LV) for single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) quantification often requires manual adjustment, which affects quantification of perfusion. We developed a machine learning approach using support vector machines (SVM) for automatic VP placement. METHODS: 392 consecutive patients undergoing fast SPECT MPI (99m)Tc-tetrofosmin stress (5 min, 300-350 MBq)/rest (5 min, 750-1050 MBq) attenuation corrected (AC) by computed tomography (CT) and same‑day coronary CT angiography (CCTA), including 48 patients with invasive angiography (ICA) and no known coronary artery disease, were studied...
November 3, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27804070/effect-of-remote-ischemic-conditioning-on-myocardial-perfusion-in-patients-with-suspected-ischemic-coronary-artery-disease
#8
Kasper Pryds, Roni Ranghøj Nielsen, Camilla Molich Hoff, Lars Poulsen Tolbod, Kirsten Bouchelouche, Jing Li, Michael Rahbek Schmidt, Andrew N Redington, Jørgen Frøkiær, Hans Erik Bøtker
BACKGROUND: Remote ischemic conditioning (RIC) confers protection against myocardial ischemia-reperfusion injury and may modulate coronary blood flow. We investigated whether RIC affects resting myocardial perfusion (MP) in patients with suspected ischemic coronary artery disease by quantitative MP imaging. METHODS AND RESULTS: We included 49 patients with suspected ischemic coronary artery disease. Resting MP was quantified by (82)Rubidium positron emission tomography/computed tomography ((82)Rb-PET/CT) imaging before and after RIC, performed as four cycles of 5 minutes upper arm ischemia and reperfusion...
November 1, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27801740/impact-of-time-of-flight-reconstruction-on-cardiac-pet-images-of-obese-patients
#9
Frank P DiFilippo, Richard C Brunken
PURPOSE: The benefit of time-of-flight (TOF) information in PET oncology studies is well established, demonstrating improved signal-to-noise ratio and enhanced lesion detection. In cardiac PET studies, tracer distribution and study interpretation differ substantially from oncology PET, and the benefit of TOF is less established. We investigate the impact of TOF on reconstructed myocardial distribution in Rb PET perfusion studies of obese patients, for whom TOF would have most significant impact...
October 31, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27793158/clinical-and-echocardiographic-predictors-of-mortality-in-acute-pulmonary-embolism
#10
Talal Dahhan, Irfan Siddiqui, Victor F Tapson, Eric J Velazquez, Stephanie Sun, Clemontina A Davenport, Zainab Samad, Sudarshan Rajagopal
PURPOSE: The aim of this study was to evaluate the utility of adding quantitative assessments of cardiac function from echocardiography to clinical factors in predicting the outcome of patients with acute pulmonary embolism (PE). METHODS: Patients with a diagnosis of acute PE, based on a positive ventilation perfusion scan or computed tomography (CT) chest angiogram, were identified using the Duke University Hospital Database. Of these, 69 had echocardiograms within 24-48 h of the diagnosis that were suitable for offline analysis...
October 28, 2016: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/27771227/diagnostic-accuracy-of-noninvasive-64-row-computed-tomographic-coronary-angiography-ccta-compared-with-myocardial-perfusion-imaging-mpi-the-picture-study-a-prospective-multicenter-trial
#11
Matthew J Budoff, Dong Li, Ella A Kazerooni, Gregory S Thomas, Jennifer H Mieres, Leslee J Shaw
RATIONALE AND OBJECTIVES: Although multiple studies have shown excellent accuracy statistics for noninvasive angiography by coronary computed tomographic angiography (CCTA), most studies comparing nuclear imaging to CCTA were performed on patients already referred for cardiac catheterization, introducing referral and selection bias. This prospective trial evaluated the diagnostic accuracy of 64-row CCTA to detect obstructive coronary stenosis compared to myocardial perfusion imaging (MPI), using quantitative coronary angiography (QCA) as a reference standard...
October 19, 2016: Academic Radiology
https://www.readbyqxmd.com/read/27768055/methods-for-the-determination-of-rates-of-glucose-and-fatty-acid-oxidation-in-the-isolated-working-rat-heart
#12
Bhavisha Bakrania, Joey P Granger, Romain Harmancey
The mammalian heart is a major consumer of ATP and requires a constant supply of energy substrates for contraction. Not surprisingly, alterations of myocardial metabolism have been linked to the development of contractile dysfunction and heart failure. Therefore, unraveling the link between metabolism and contraction should shed light on some of the mechanisms governing cardiac adaptation or maladaptation in disease states. The isolated working rat heart preparation can be used to follow, simultaneously and in real time, cardiac contractile function and flux of energy providing substrates into oxidative metabolic pathways...
September 28, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27751974/assessment-of-heart-rate-recovery-with-gated-myocardial-perfusion-scintigraphy-outcome-in-patients-with-coronary-artery-disease-a-retrospective-study-and-institutional-experience
#13
Yusuf Ziya Tan, Semra Özdemir, Burak Altun, Fatmanur Çelik
OBJECTIVE: This study aimed to investigate the effects of assessment with myocardial perfusion scintigraphy (MPS) and heart rate recovery (HRrec) measurements in combination to evaluate the current status of patients with a diagnosis or suspicion of coronary artery disease (CAD). METHODS: A total of 350 patients were included in the study. CAD group consisted of 200 patients with stable angina pectoris and a known history of CAD, while the control group consisted of 150 patients with suspicious stress test who had no history of known CAD...
October 5, 2016: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/27747165/use-of-bio-informatics-assessment-schema-bias-to-improve-diagnosis-and-prognosis-of-myocardial-perfusion-data-results-from-the-nhlbi-sponsored-women-s-ischemia-syndrome-evaluation-wise
#14
Mark Doyle, Gerald M Pohost, C Noel Bairey Merz, Leslee J Shaw, George Sopko, William J Rogers, Barry L Sharaf, Carl J Pepine, Diane V Thompson, Geetha Rayarao, Lindsey Tauxe, Sheryl F Kelsey, Robert W W Biederman
BACKGROUND: We introduce an algorithmic approach to optimize diagnostic and prognostic value of gated cardiac single photon emission computed tomography (SPECT) and magnetic resonance (MR) myocardial perfusion imaging (MPI) modalities in women with suspected myocardial ischemia. The novel approach: bio-informatics assessment schema (BIAS) forms a mathematical model utilizing MPI data and cardiac metrics generated by one modality to predict the MPI status of another modality. The model identifies cardiac features that either enhance or mask the image-based evidence of ischemia...
October 2016: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/27743297/-same-patient-processing-for-multiple-cardiac-spect-studies-2-improving-quantification-repeatability
#15
Guido Germano, Paul B Kavanagh, Terrence D Ruddy, R Glenn Wells, Yuan Xu, Daniel S Berman, Piotr J Slomka
OBJECTIVES: This paper investigates the ability of grouped quantification (an expression of the same-patient processing approach, or SPP) to improve repeatability of measurements in patients with multiple SPECT studies, and evaluates its performance compared to standard quantification in a population of 100 patients undergoing rest, stress, gated rest, and gated stress SPECT MPI. All acquisitions were performed twice, back-to-back, for a total of 800 image datasets (8 per patient). METHODS: Each dataset was automatically processed (a) independently, using standard quantitative software, and (b) as a group, together with the other 7 datasets belonging to the same patient, using an SPP-modified version of the software that registered the images to one another using a downhill simplex algorithm for the search of optimal translation, rotation, and scaling parameters...
October 14, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27712778/mechanisms-of-myocardial-ischemia-in-hypertrophic-cardiomyopathy-insights-from-wave-intensity-analysis-and-magnetic-resonance
#16
Claire E Raphael, Robert Cooper, Kim H Parker, Julian Collinson, Vassilis Vassiliou, Dudley J Pennell, Ranil de Silva, Li Yueh Hsu, Anders M Greve, Sukh Nijjer, Chris Broyd, Aamir Ali, Jennifer Keegan, Darrel P Francis, Justin E Davies, Alun D Hughes, Andrew Arai, Michael Frenneaux, Rod H Stables, Carlo Di Mario, Sanjay K Prasad
BACKGROUND: Angina is common in hypertrophic cardiomyopathy (HCM) and is associated with abnormal myocardial perfusion. Wave intensity analysis improves the understanding of the mechanics of myocardial ischemia. OBJECTIVES: Wave intensity analysis was used to describe the mechanisms underlying perfusion abnormalities in patients with HCM. METHODS: Simultaneous pressure and flow were measured in the proximal left anterior descending artery in 33 patients with HCM and 20 control patients at rest and during hyperemia, allowing calculation of wave intensity...
October 11, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27638746/optimizing-quantitative-myocardial-perfusion-by-positron-emission-tomography-for-guiding-cad-management
#17
K Lance Gould
No abstract text is available yet for this article.
September 14, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27624746/quantitative-assessment-of-myocardial-blood-flow-in-coronary-artery-disease-by-cardiovascular-magnetic-resonance-comparison-of-fermi-and-distributed-parameter-modeling-against-invasive-methods
#18
Giorgos Papanastasiou, Michelle C Williams, Marc R Dweck, Shirjel Alam, Annette Cooper, Saeed Mirsadraee, David E Newby, Scott I Semple
BACKGROUND: Mathematical modeling of perfusion cardiovascular magnetic resonance (CMR) data allows absolute quantification of myocardial blood flow and can potentially improve the diagnosis and prognostication of obstructive coronary artery disease (CAD), against the current clinical standard of visual assessments. This study compares the diagnostic performance of distributed parameter modeling (DP) against the standard Fermi model, for the detection of obstructive CAD, in per vessel against per patient analysis...
2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27611708/non-invasive-measurement-of-coronary-flow-reserve-uniqueness-of-radionuclide-methods-and-alternative-techniques
#19
Matteo Bauckneht, Roberta Piva, Giulia Ferrarazzo, Valentina Ceriani, Ambra Buschiazzo, Silvia Morbelli, Cecilia Marini, Gianmario Sambuceti
Over the last several decades, radionuclide Myocardial Perfusion Imaging (MPI) has been a mainstay for the evaluation of coronary artery disease (CAD), based on the assumption that a detailed knowledge of stenosis localization and severity is not sufficient for clinical decision making. Furthermore, radionuclide MPI diagnostic accuracy has been implemented by the assessment of Coronary Flow Reserve (CFR) and Myocardial Blood Flow (MBF), as quantitative indexes of stenosis severity and surrogates of total ischaemic burden...
December 2016: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27609817/integrated-myocardial-perfusion-imaging-diagnostics-improve-detection-of-functionally-significant-coronary-artery-stenosis-by-13n-ammonia-positron-emission-tomography
#20
Joo Myung Lee, Chee Hae Kim, Bon-Kwon Koo, Doyeon Hwang, Jonghanne Park, Jinlong Zhang, Yaliang Tong, Ki-Hyun Jeon, Ji-In Bang, Minseok Suh, Jin Chul Paeng, Gi Jeong Cheon, Sang-Hoon Na, Jung-Min Ahn, Seung-Jung Park, Hyo-Soo Kim
BACKGROUND: Recent evidence suggests that the diagnostic accuracy of myocardial perfusion imaging is improved by quantifying stress myocardial blood flow (MBF) in absolute terms. We evaluated a comprehensive quantitative (13)N-ammonia positron emission tomography ((13)NH3-PET) diagnostic panel, including stress MBF, coronary flow reserve (CFR), and relative flow reserve (RFR) in conjunction with relative perfusion defect (PD) assessments to better detect functionally significant coronary artery stenosis...
September 2016: Circulation. Cardiovascular Imaging
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