John Kane, Xue Li, Sudhir Kumar, Katrina A Button-Simons, Katelyn M Vendrely Brenneman, Haley Dahlhoff, Mackenzie A C Sievert, Lisa A Checkley, Douglas A Shoue, Puspendra P Singh, Biley A Abatiyow, Meseret T Haile, Shalini Nair, Ann Reyes, Rupam Tripura, Tom Peto, Dysoley Lek, Stefan H I Kappe, Mehul Dhorda, Standwell C Nkhoma, Ian H Cheeseman, Ashley M Vaughan, Timothy J C Anderson, Michael T Ferdig
UNLABELLED: Piperaquine (PPQ) is widely used in combination with dihydroartemisinin (DHA) as a first-line treatment against malaria parasites. Multiple genetic drivers of PPQ resistance have been reported, including mutations in the Plasmodium falciparum chloroquine resistance transporter ( pfcrt ) and increased copies of plasmepsin II/III ( pm2/3 ). We generated a cross between a Cambodia-derived multi-drug resistant KEL1/PLA1 lineage isolate (KH004) and a drug susceptible parasite isolated in Malawi (Mal31)...
September 17, 2023: bioRxiv