keyword
MENU ▼
Read by QxMD icon Read
search

DHA transporter

keyword
https://www.readbyqxmd.com/read/29909178/the-effect-of-apoe-genotype-on-alzheimer-s-disease-risk-is-influenced-by-sex-and-docosahexaenoic-acid-status
#1
REVIEW
Matthew Pontifex, David Vauzour, Anne-Marie Minihane
An apolipoprotein E ε4 (APOE-ε4) genotype is the strongest common genetic determinant of Alzheimer's disease (AD). The pleiotropic nature of apolipoprotein E has made elucidation of the aetiological basis difficult to establish, which is further complicated by the fact that the penetrance of the APOE-ε4 allele is modulated by sex, age, and nutrition. A greater metabolic consequence of the APOE-ε4 allele is likely to contribute to the fact that two-thirds of AD patients are female. A higher tissue status of the marine n-3 fatty acid docosahexaenoic acid (DHA) is associated with a lower AD risk...
May 21, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29858775/targeting-the-brain-with-a-neuroprotective-omega-3-fatty-acid-to-enhance-neurogenesis-in-hypoxic-condition-in-culture
#2
Amanda Lo Van, Nobuyuki Sakayori, Mayssa Hachem, Mounir Belkouch, Madeleine Picq, Baptiste Fourmaux, Michel Lagarde, Noriko Osumi, Nathalie Bernoud-Hubac
Docosahexaenoic acid (DHA, 22:6n-3) is an essential omega-3 polyunsaturated fatty acid (PUFA) that is required for proper brain development and cerebral functions. While DHA deficiency in the brain was shown to be linked to the emergence of cerebral diseases, a dietary intake of omega-3 PUFA could prevent or attenuate neurologic disturbances linked with aging or neurodegenerative diseases. In this context, targeting the brain with DHA might offer great promise in developing new therapeutics for neurodegenerative diseases...
June 1, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29850457/n-3-polyunsaturated-fatty-acids-stimulate-bile-acid-detoxification-in-human-cell-models
#3
Anna Cieślak, Jocelyn Trottier, Mélanie Verreault, Piotr Milkiewicz, Marie-Claude Vohl, Olivier Barbier
Cholestasis is characterized by the accumulation of toxic bile acids (BAs) in liver cells. The present study aimed to evaluate the effects of n-3 polyunsaturated fatty acids (n-3 PUFAs), such as docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids, on BA homeostasis and toxicity in human cell models. The effects of EPA and/or DHA on the expression of genes involved in the maintenance of BA homeostasis were analyzed in human hepatoma (HepG2) and colon carcinoma (Caco-2) cells, as well as in primary culture of human intestinal (InEpC) and renal (RPTEC) cells...
2018: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29844613/metastatic-brain-tumors-disrupt-the-blood-brain-barrier-and-alter-lipid-metabolism-by-inhibiting-expression-of-the-endothelial-cell-fatty-acid-transporter-mfsd2a
#4
Shweta Tiwary, John E Morales, Sam C Kwiatkowski, Frederick F Lang, Ganesh Rao, Joseph H McCarty
Disruption of the blood-brain barrier (BBB) by cancer cells is linked to metastatic tumor initiation and progression; however, the pathways that drive these events remain poorly understood. Here, we have developed novel patient-derived xenograft (PDX) models of brain metastases that recapitulate pathological growth features found in original patient samples, thus allowing for analysis of BBB disruption by tumor cells. We report that the BBB is selectively disrupted in brain metastases, in part, via inhibition of the endothelial cell-expressed docosahexaenoic acid (DHA) transporter, major facilitator superfamily domain 2a (Mfsd2a)...
May 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29764451/phenotypic-and-genotypic-characterization-of-thai-isolates-of-plasmodium-falciparum-after-an-artemisinin-resistance-containment-project
#5
Thunyapit Thita, Pimrat Jadsri, Jarupatr Thamkhantho, Toon Ruang-Areerate, Nantana Suwandittakul, Naruemon Sitthichot, Kittiya Mahotorn, Peerapan Tan-Ariya, Mathirut Mungthin
BACKGROUND: In Thailand, artemisinin-based combination therapy (ACT) has been used to treat uncomplicated falciparum malaria since 1995. Unfortunately, artemisinin resistance has been reported from Thailand and other Southeast Asian countries since 2003. Malarone® , a combination of atovaquone-proguanil (ATQ-PG), has been used to cease artemisinin pressure in some areas along Thai-Cambodia border, as part of an artemisinin resistance containment project since 2009. This study aimed to determine genotypes and phenotypes of Plasmodium falciparum isolates collected from the Thai-Cambodia border after the artemisinin resistance containment project compared with those collected before...
May 15, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29699561/docosahexaenoic-acid-dha-effects-on-proliferation-and-steroidogenesis-of-bovine-granulosa-cells
#6
Virginie Maillard, Alice Desmarchais, Maeva Durcin, Svetlana Uzbekova, Sebastien Elis
BACKGROUND: Docosahexaenoic acid (DHA) is a n-3 polyunsaturated fatty acid (PUFA) belonging to a family of biologically active fatty acids (FA), which are known to have numerous health benefits. N-3 PUFAs affect reproduction in cattle, and notably directly affect follicular cells. In terms of reproduction in cattle, n-3 PUFA-enriched diets lead to increased follicle size or numbers. METHODS: The objective of the present study was to analyze the effects of DHA (1, 10, 20 and 50 μM) on proliferation and steroidogenesis (parametric and/or non parametric (permutational) ANOVA) of bovine granulosa cells in vitro and mechanisms of action through protein expression (Kruskal-Wallis) and signaling pathways (non parametric ANOVA) and to investigate whether DHA could exert part of its action through the free fatty acid receptor 4 (FFAR4)...
April 26, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29582413/dietary-docosahexaenoic-acid-supplementation-enhances-expression-of-fatty-acid-binding-protein-5-at-the-blood-brain-barrier-and-brain-docosahexaenoic-acid-levels
#7
Yijun Pan, Elonie R Morris, Martin J Scanlon, Philip J Marriott, Christopher Jh Porter, Joseph A Nicolazzo
The cytoplasmic trafficking of docosahexaenoic acid (DHA), a cognitively-beneficial fatty acid, across the blood-brain barrier (BBB) is governed by fatty acid-binding protein 5 (FABP5). Lower levels of brain DHA have been observed in Alzheimer's disease (AD), which is associated with diminished BBB expression of FABP5. Therefore, upregulating FABP5 expression at the BBB may be a novel approach for enhancing BBB transport of DHA in AD. DHA supplementation has been shown to be beneficial in various mouse models of AD, and therefore, the aim of this study was to determine whether DHA has the potential to upregulate the BBB expression of FABP5, thereby enhancing its own uptake into the brain...
March 27, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29568239/effects-of-the-complete-replacement-of-fish-oil-with-linseed-oil-on-growth-fatty-acid-composition-and-protein-expression-in-the-chinese-mitten-crab-eriocheir-sinensis
#8
Banghong Wei, Zhigang Yang, Yongxu Cheng, Jianyi Wang, Junyu Zhou
Background: The finite marine resources make it difficult for us to obtain enough fish oil (FO) used in aquatic feeds. Another sustainable ingredients should be found to substitute FO. The effects of replacing FO with vegetable oil have been studied in a variety of crustaceans, but most studies have focused on the phenotypic effects. Little is known about the mechanisms of the effects. Methods: To understand the molecular responses during the replacement of FO in Eriocheir sinensis , we investigated the effects of feeding FO or linseed oil (LO) on growth performance, digestive enzyme activity, fatty acid composition and protein expression in E...
2018: Proteome Science
https://www.readbyqxmd.com/read/29567393/ascorbic-acid-metabolism-and-functions-a-comparison-of-plants-and-mammals
#9
Nicholas Smirnoff
Ascorbic acid is synthesised by eukaryotes, the known exceptions being primates and some other animal groups which have lost functional gulonolactone oxidase. Prokaryotes do not synthesise ascorbate and do not need an ascorbate supply, so the functions that are essential for mammals and plants are not required or are substituted by other compounds. The ability of ascorbate to donate electrons enables it to act as a free radical scavenger and to reduce higher oxidation states of iron to Fe2+ . These reactions are the basis of its biological activity along with the relative stability of the resulting resonance stabilised monodehydroascorbate radical...
March 20, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29541085/physiological-and-proteomic-responses-of-contrasting-alfalfa-medicago-sativa-l-varieties-to-peg-induced-osmotic-stress
#10
Cuimei Zhang, Shangli Shi
Drought severely limits global plant distribution and agricultural production. Elucidating the physiological and molecular mechanisms governing alfalfa stress responses will contribute to the improvement of drought tolerance in leguminous crops. In this study, the physiological and proteomic responses of two alfalfa ( Medicago sativa L.) varieties contrasting in drought tolerance, Longzhong (drought-tolerant) and Gannong No. 3 (drought-sensitive), were comparatively assayed when seedlings were exposed to -1...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29504077/assessment-of-heavy-metal-pollution-risks-and-enzyme-activity-of-meadow-soils-in-urban-area-under-tourism-load-a-case-study-from-zakopane-poland
#11
Krystyna Ciarkowska
Effect of tourism, especially skiing activities, and urbanization on chemical and biochemical properties of soils in touristy town-Zakopane-was investigated. The concentration of heavy metals, nutrients, soil organic matter (SOM), dehydrogenase (DHA), invertase (IA) and urease (Ure) activities in soils from the town centre and out of the town centre was compared with the respective values of adjacent soils in protected areas (TNP). In order to evaluate a degree of contamination and risks of degradation enrichment factor (EF), ecological risk index (RI), Nemerov Pollution Index (PINemerov ) as well as enzyme activity index (EAI) were calculated...
March 4, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29492971/pro-inflammatory-and-anti-inflammatory-compounds-exert-similar-effects-on-p-glycoprotein-in-blood-brain-barrier-endothelial-cells
#12
Pablo Torres-Vergara, Jeffrey Penny
OBJECTIVES: The effects of anti-inflammatory glucocorticoids dexamethasone (DX) and hydrocortisone (HC), pro-inflammatory cytokine interleukin-1β (IL-1β) and dietary long-chain polyunsaturated fatty acids (PUFAs) on expression and activity of the ATP-binding cassette transporter P-glycoprotein (P-GP) were studied in porcine brain endothelial cells (PBECs). METHODS: Primary PBECs were treated for 24 h with glucocorticoids, IL-1β and long-chain PUFAs. P-GP activity was determined by measuring intracellular calcein accumulation and P-GP expression by Western blotting...
June 2018: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29477225/water-soluble-vitamin-e-tocopheryl-phosphate
#13
REVIEW
Jean-Marc Zingg
The hydrophobicity of vitamin E poses transport and metabolic challenges to regulate its bioavailability and to prevent its accumulation in lipid-rich tissues such as adipose tissue, brain, and liver. Water-soluble precursors of vitamin E (α-tocopherol, αT), such as its esters with acetate (αTA), succinate (αTS), or phosphate (αTP), have increased solubility in water and stability against reaction with free radicals, but they are rapidly converted during their uptake into the lipid-soluble vitamin E. Therefore, the bioavailability of these precursors as intact molecules is low; nevertheless, at least for αTS and αTP, the recent research has revealed unique regulatory effects on signal transduction and gene expression and the modulation of cellular events ranging from proliferation, survival/apoptosis, lipid uptake and metabolism, phagocytosis, long term potentiation, cell migration, telomere maintenance, and angiogenesis...
2018: Advances in Food and Nutrition Research
https://www.readbyqxmd.com/read/29463265/fatty-acids-modulate-the-expression-levels-of-key-proteins-for-cholesterol-absorption-in-caco-2-monolayer
#14
Fang Yang, Guoxun Chen, Meihu Ma, Ning Qiu, Lingjiao Zhu, Jing Li
BACKGROUND: Fatty acids have been shown to modulate intestinal cholesterol absorption in cells and animals, a process that is mediated by several transporter proteins. Of these proteins, Niemann-Pick C1-Like 1 (NPC1L1) is a major contributor to this process. The current study investigates the unknown mechanism by which fatty acids modulate cholesterol absorption. METHODS: We evaluated the effects of six fatty acids palmitic acid (PAM), oleic acid (OLA), linoleic acid (LNA), arachidonic acid (ARA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on cholesterol uptake and transport in human enterocytes Caco-2 cells, and on the mRNA expression levels of NPC1L1, others proteins (ABCG5, ABCG8, ABCA1, ACAT2, MTP, Caveolin 1, Annexin-2) involved in cholesterol absorption, and SREBP-1 and SREBP-2 that are responsible for lipid metabolism...
February 20, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29463009/docosahexaenoic-acid-helps-to-lessen-extinction-memory-in-rats
#15
Michio Hashimoto, Shahdat Hossain, Masanori Katakura, Abdullah Al Mamun, Osamu Shido
Abstract : Memory extinction is referred to as a learning process in which a conditioned response (CR) progressively reduces over time as an animal learns to uncouple a response from a stimulus. Extinction occurs when the rat is placed into a context without shock after training. Docosahexaenoic acid (DHA, C22:6, n-3) is implicated in memory formation in mammalian brains. In a two-way active shuttle-avoidance apparatus, we examined whether DHA affects the extinction memory and the expression of brain cognition-related proteins, including gastrin-releasing peptide receptor (GRPR), brain-derived neurotrophic factor receptor (BDNFR) tyrosine kinase receptor B (TrKB), and N-methyl-d-aspartate receptor (NMDAR) subunits NR2A and NR2B...
February 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29462922/differential-long-chain-polyunsaturated-fatty-acids-status-and-placental-transport-in-adolescent-pregnancies
#16
Fernanda Carrilho Pinto da Fonseca, Daniela de Barros Mucci, Renata Pereira Assumpção, Henrique Marcondes, Fátima Lúcia de Carvalho Sardinha, Simone Vargas Silva, Marta Citelli, Maria das Graças Tavares do Carmo
Adolescent pregnancy increases risk of adverse perinatal outcomes. Placental delivery of long-chain polyunsaturated fatty acids (LCPUFA) is essential for fetal growth and development. In this pilot study, we aimed to assess maternal and fetal status of fatty acids (FA) measured at birth and the expression of key genes involved in FA uptake, transport and metabolism in the placenta of fifteen adolescents and fifteen adults. FA were quantified by gas-liquid chromatography. Placental expression of FA transporters was assessed by quantitative real-time polymerase chain reaction (qRT-PCR) and peroxisome proliferator-activated receptor gamma (PPARγ) was quantified by Western Blot...
February 16, 2018: Nutrients
https://www.readbyqxmd.com/read/29458208/the-use-of-fatty-acids-as-absorption-enhancer-for-pulmonary-drug-delivery
#17
Maliheh Ghadiri, Finbarr Canney, Cristina Pacciana, Gaia Colombo, Paul M Young, Daniela Traini
A limitation in the systemic uptake of many inhalable drugs is the restricted permeation through the pulmonary epithelial layer barrier. One strategy to bypass the epithelial layer when delivering non-permeable drugs is to alter the paracellular transport, allowing the uptake of drugs into the systemic circulation. In this study, the potential of sodium decanoate (Na dec), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) as absorption enhancers has been investigated to increase pulmonary paracellular permeability by modulating epithelial cells' tight junctions...
April 25, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29288796/dha-mitigates-autistic-behaviors-accompanied-by-dopaminergic-change-in-a-gene-prenatal-stress-mouse-model
#18
Fumihiro Matsui, Patrick Hecht, Kanji Yoshimoto, Yoshihisa Watanabe, Masafumi Morimoto, Kevin Fritsche, Matthew Will, David Beversdorf
Autism Spectrum Disorder (ASD) is characterized by impairments in social interaction, social communication, and repetitive and stereotyped behaviors. Recent work has begun to explore gene × environmental interactions in the etiology of ASD. We previously reported that prenatal stress exposure in stress-susceptible heterozygous serotonin transporter (SERT) KO pregnant dams in a mouse model resulted in autism-like behavior in the offspring (SERT/S mice). The association between prenatal stress and ASD appears to be affected by maternal SERT genotype in clinical populations as well...
February 10, 2018: Neuroscience
https://www.readbyqxmd.com/read/29274292/butyrate-and-docosahexaenoic-acid-interact-in-alterations-of-specific-lipid-classes-in-differentiating-colon-cancer-cells
#19
Zuzana Tylichová, Josef Slavík, Miroslav Ciganek, Petra Ovesná, Pavel Krčmář, Nicol Straková, Miroslav Machala, Alois Kozubík, Jiřina Hofmanová, Jan Vondráček
Docosahexaenoic acid (DHA) and sodium butyrate (NaBt) exhibit a number of interactive effects on colon cancer cell growth, differentiation, or apoptosis; however, the molecular mechanisms responsible for these interactions and their impact on cellular lipidome are still not fully clear. Here, we show that both dietary agents together induce dynamic alterations of lipid metabolism, specific cellular lipid classes, and fatty acid composition. In HT-29 cell line, a model of differentiating colon carcinoma cells, NaBt supported incorporation of free DHA into non-polar lipids and their accumulation in cytoplasmic lipid droplets...
June 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29229294/impact-of-dha-intake-in-a-mouse-model-of-synucleinopathy
#20
Katherine Coulombe, Olivier Kerdiles, Cyntia Tremblay, Vincent Emond, Manon Lebel, Anne-Sophie Boulianne, Mélanie Plourde, Francesca Cicchetti, Frédéric Calon
Polyunsaturated fatty acids omega-3 (n-3 PUFA), such as docosahexaenoic acid (DHA), have been shown to prevent, and partially reverse, neurotoxin-induced nigrostriatal denervation in animal models of Parkinson's disease (PD). However, the accumulation of α-synuclein (αSyn) in cerebral tissues is equally important to the pathophysiology. To determine whether DHA intake improves various aspects related to synucleinopathy, ninety male mice overexpressing human αSyn under the Thy-1 promoter (Thy1-αSyn) were fed one of three diets (specially formulated control, low n-3 PUFA or high DHA) and compared to non-transgenic C57/BL6 littermate mice exposed to a control diet...
March 2018: Experimental Neurology
keyword
keyword
102875
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"