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DHA transporter

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https://www.readbyqxmd.com/read/29053802/docosahexaenoic-acid-supplementation-in-pregnancy-modulates-placental-cellular-signaling-and-nutrient-transport-capacity-in-obese-women
#1
Susanne Lager, Vanessa I Ramirez, Ometeotl Acosta, Christiane Meireles, Evelyn Miller, Francesca Gaccioli, Fredrick J Rosario, Jonathan A L Gelfond, Kevin Hakala, Susan T Weintraub, Debra A Krummel, Theresa L Powell
Context: Maternal obesity in pregnancy has profound impacts on maternal metabolism and promotes placental nutrient transport, which may contribute to fetal overgrowth in these pregnancies. The fatty acid docosahexaenoic acid (DHA) has bioactive properties that may improve outcomes in obese pregnant women by modulating placental function. Objective: To determine the effects of DHA supplementation in obese pregnant women on maternal metabolism and placental function...
October 18, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29049903/glutamate-homeostasis-in-the-adult-rat-prefrontal-cortex-is-altered-by-cortical-docosahexaenoic-acid-accrual-during-adolescence-an-in-vivo-1-h-mrs-study
#2
Robert K McNamara, Ruth H Asch, Jennifer D Schurdak, Diana M Lindquist
Major psychiatric disorders are associated with dysregulated glutamate homeostasis and deficits in the omega-3 fatty acid docosahexaenoic acid (DHA). This study determined the effects of dietary-induced alterations in brain DHA accrual on cortical glutamate homeostasis in the adult rat brain. Adolescent rats were fed a control diet (n = 20), a n-3 fatty acid-deficient diet (DEF, n = 20), or a fish oil-fortified diet containing preformed DHA (FO, n = 20). In adulthood (1)H MRS scans were performed with voxels in the prefrontal cortex (PFC) and thalamus...
October 11, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28990478/changes-in-plasma-and-tissue-long-chain-polyunsaturated-fatty-acid-lc-pufa-content-in-the-eel-anguilla-japonica-after-external-and-internal-osmotic-stress
#3
Qinghao Zhang, Marty K S Wong, Yiqi Li, Yuanyou Li, Yoshio Takei
We investigated the effect of external and internal osmotic stress on the profile of long-chain polyunsaturated fatty acids (LC-PUFA) in euryhaline eels Anguilla japonica. Freshwater (FW) fish were transferred to seawater (SW) for external osmotic stress or subjected to internal stress through injection with hypertonic saline. FW eels injected with isotonic saline served as controls. Plasma osmolality, Na(+) concentration, and gill Na(+)/K(+) -ATPase activity increased, but hematocrit decreased compared with controls in eels exposed to external or internal osmotic stress...
October 2017: Zoological Science
https://www.readbyqxmd.com/read/28987718/fatty-acid-profile-of-maternal-and-fetal-erythrocytes-and-placental-expression-of-fatty-acid-transport-proteins-in-normal-and-intrauterine-growth-restriction-pregnancies
#4
Renata P Assumpção, Daniela B Mucci, Fernanda C P Fonseca, Henrique Marcondes, Fátima L C Sardinha, Marta Citelli, Maria G Tavares do Carmo
Long-chain polyunsaturated fatty acids (LC-PUFA), mainly docosahexaenoic (DHA) and arachidonic acids (AA), are critical for adequate fetal growth and development. We investigated mRNA expression of proteins involved in hydrolysis, uptake and/or transport of fatty acids in placenta of fifteen full term normal pregnancies and eleven pregnancies complicated by intrauterine growth restriction (IUGR) with normal umbilical blood flows. The mRNA expression of LPL, FATPs (-1, -2 and -4) and FABPs (-1 and -3) was increased in IUGR placentas, however, tissue profile of LC-PUFA was not different between groups...
October 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28931587/maternal-choline-supplementation-modulates-placental-nutrient-transport-and-metabolism-in-late-gestation-of-mouse-pregnancy
#5
Sze Ting Cecilia Kwan, Julia H King, Jian Yan, Zhen Wang, Xinyin Jiang, Jason S Hutzler, Hallie R Klein, J Thomas Brenna, Mark S Roberson, Marie A Caudill
Background: Fetal growth is dependent on placental nutrient supply, which is influenced by placental perfusion and transporter abundance. Previous research indicates that adequate choline nutrition during pregnancy improves placental vascular development, supporting the hypothesis that choline may affect placental nutrient transport.Objective: The present study sought to determine the impact of maternal choline supplementation (MCS) on placental nutrient transporter abundance and nutrient metabolism during late gestation...
September 20, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28917610/low-dose-dha-induced-astrocyte-proliferation-can-be-attenuated-by-insufficient-expression-of-blbp-in-vitro
#6
Haoming Li, Qingqing Yang, Xiao Han, Xuefeng Tan, Jianbing Qin, Guohua Jin
Docosahexaenoic acid (DHA) is an n-3 long chain polyunsaturated fatty acid (PUFA) that is involved in a wide range of cellular processes in human cells. Brain lipid binding protein (BLBP) exhibits a high affinity for n-3 PUFAs, especially DHA, but the precise functional contributions of DHA and BLBP in astrocytes are not clear. We analyzed cell viability and the ratio of Ki67 positive cells after manipulating DHA and/or BLBP levels in cultured astrocytes, and found that low-dose DHA stimulated proliferation of astrocytes, whereas this proliferative effect could be attenuated by downregulation of BLBP...
September 13, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28900242/dietary-docosahexaenoic-acid-dha-as-lysophosphatidylcholine-but-not-as-free-acid-enriches-brain-dha-and-improves-memory-in-adult-mice
#7
Dhavamani Sugasini, Riya Thomas, Poorna C R Yalagala, Leon M Tai, Papasani V Subbaiah
Docosahexaenoic acid (DHA) is uniquely concentrated in the brain, and is essential for its function, but must be mostly acquired from diet. Most of the current supplements of DHA, including fish oil and krill oil, do not significantly increase brain DHA, because they are hydrolyzed to free DHA and are absorbed as triacylglycerol, whereas the transporter at blood brain barrier is specific for phospholipid form of DHA. Here we show that oral administration of DHA to normal adult mice as lysophosphatidylcholine (LPC) (40 mg DHA/kg) for 30 days increased DHA content of the brain by >2-fold...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28851583/chemical-transport-knockout-for-oxidized-vitamin-c-dehydroascorbic-acid-reveals-its-functions-in-vivo
#8
Hongbin Tu, Yu Wang, Hongyan Li, Lauren R Brinster, Mark Levine
Despite its transport by glucose transporters (GLUTs) in vitro, it is unknown whether dehydroascorbic acid (oxidized vitamin C, DHA) has any in vivo function. To investigate, we created a chemical transport knockout model using the vitamin C analog 6-bromo-ascorbate. This analog is transported on sodium-dependent vitamin C transporters but its oxidized form, 6-bromo-dehydroascorbic acid, is not transported by GLUTs. Mice (gulo(-/-)) unable to synthesize ascorbate (vitamin C) were raised on 6-bromo-ascorbate...
September 2017: EBioMedicine
https://www.readbyqxmd.com/read/28830769/plasmalogen-precursor-mitigates-striatal-dopamine-loss-in-mptp-mice
#9
Edith Miville-Godbout, Mélanie Bourque, Marc Morissette, Sara Al-Sweidi, Tara Smith, Dushmanthi Jayasinghe, Shawn Ritchie, Thérèse Di Paolo
Ethanolamine plasmalogens (PlsEtn) are a class of glycerophospholipids characterized by a vinyl-ether bond at the sn-1 position that play an important role in the structure and function of membranes. Previous reports have suggested a link between reduced blood and brain PlsEtn levels and Parkinson's disease (PD). We recently reported that the DHA containing plasmalogen precursor PPI-1011 protected striatal dopamine (DA) against MPTP toxicity in mice. In this paper, we further investigate the specificity requirements of the lipid side chains by testing the oleic acid-containing plasmalogen precursor PPI-1025...
August 19, 2017: Brain Research
https://www.readbyqxmd.com/read/28827082/mfsd2a-promotes-endothelial-generation-of-inflammation-resolving-lipid-mediators-and-reduces-colitis%C3%A2-in%C3%A2-mice
#10
Federica Ungaro, Carlotta Tacconi, Luca Massimino, Paola Antonia Corsetto, Carmen Correale, Philippe Fonteyne, Andrea Piontini, Valeria Garzarelli, Francesca Calcaterra, Silvia Della Bella, Antonino Spinelli, Michele Carvello, Angela Maria Rizzo, Stefania Vetrano, Luciana Petti, Gionata Fiorino, Federica Furfaro, Domenico Mavilio, Krishna Rao Maddipati, Alberto Malesci, Laurent Peyrin-Biroulet, Silvia D'Alessio, Silvio Danese
BACKGROUND & AIMS: Alterations in signaling pathways that regulate resolution of inflammation (resolving pathways) contribute to pathogenesis of ulcerative colitis (UC). The resolution process is regulated by lipid mediators, such as those derived from the ω-3 docosahexaenoic acid (DHA), whose esterified form is transported by the major facilitator superfamily domain containing 2A (MFSD2A) through the endothelium of brain, retina, and placenta. We investigated if and how MFSD2A regulates lipid metabolism of gut endothelial cells to promote resolution of intestinal inflammation...
August 4, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28804003/effect-and-proposed-mechanism-of-vitamin-c-modulating-amino-acid-regulation-of-autophagic-proteolysis
#11
Md Razaul Karim, Motoni Kadowaki
Autophagy is an intracellular bulk degradation process, induced under nutrient starvation. Failure of autophagy has been recognized as a contributor to aging and multiple age related neurodegenerative diseases. Improving autophagy is a beneficial anti-aging strategy, however very few physiological regulators have been identified. Here, we demonstrate that vitamin C is a nutritional stimulator of autophagy. Supplementation of fresh hepatocytes with vitamin C increased autophagic proteolysis significantly in the presence of amino acids in a dose- and time-dependent manner, although no effect was observed in the absence of amino acids...
August 10, 2017: Biochimie
https://www.readbyqxmd.com/read/28780271/process-optimization-and-analysis-of-product-inhibition-kinetics-of-crude-glycerol-fermentation-for-1-3-dihydroxyacetone-production
#12
Pritam Kumar Dikshit, Susant Kumar Padhi, Vijayanand S Moholkar
In present study, statistical optimization of biodiesel-derived crude glycerol fermentation to DHA by immobilized G. oxydans cells over polyurethane foam is reported. Effect of DHA (product) inhibition on crude glycerol fermentation was analyzed using conventional biokinetic models and new model that accounts for both substrate and product inhibition. Optimum values of fermentation parameters were: pH=4.7, temperature=31°C, initial substrate concentration=20g/L. At optimum conditions, DHA yield was 89% (17...
November 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28760485/phospholipid-class-specific-brain-enrichment-in-response-to-lysophosphatidylcholine-docosahexaenoic-acid-infusion
#13
Raphaël Chouinard-Watkins, Chuck T Chen, Adam H Metherel, R J Scott Lacombe, Frank Thies, Mojgan Masoodi, Richard P Bazinet
Recent studies suggest that at least two pools of plasma docosahexaenoic acid (DHA) can supply the brain: non-esterified DHA (NE-DHA) and lysophosphatidylcholine (lysoPtdCho)-DHA. In contrast to NE-DHA, brain uptake of lysoPtdCho-DHA appears to be mediated by a specific transporter, but whether both forms of DHA supply undergo the same metabolic fate, particularly with regards to enrichment of specific phospholipid (PL) subclasses, remains to be determined. This study aimed to evaluate brain uptake of NE-DHA and lysoPtdCho-DHA into brain PL classes...
October 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28699359/mitochondrial-uptake-and-accumulation-of-vitamin-c-what-can-we-learn-from-cell-culture-studies
#14
Orazio Cantoni, Andrea Guidarelli, Mara Fiorani
SIGNIFICANCE: The mitochondrial fraction of l-ascorbic acid (AA) is of critical importance for the regulation of the redox status of these organelles and for cell survival. Recent Advances: Most cell types take up AA by the high-affinity sodium-dependent vitamin C transporter 2 (SVCT2) sensitive to inhibition by dehydroascorbic acid (DHA). DHA can also be taken up by glucose transporters (GLUTs) and then reduced back to AA. DHA concentrations, normally very low in biological fluids, may only become significant next to superoxide-releasing cells...
August 9, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28686542/polyunsaturated-fatty-acids-and-endocannabinoids-in-health-and-disease
#15
Hércules Rezende Freitas, Alinny Rosendo Isaac, Renato Malcher-Lopes, Bruno Lourenço Diaz, Isis Hara Trevenzoli, Ricardo Augusto De Melo Reis
Polyunsaturated fatty acids (PUFAs) are lipid derivatives of omega-3 (docosahexaenoic acid, DHA, and eicosapentaenoic acid, EPA) or of omega-6 (arachidonic acid, ARA) synthesized from membrane phospholipids and used as a precursor for endocannabinoids (ECs). They mediate significant effects in the fine-tune adjustment of body homeostasis. Phyto- and synthetic cannabinoids also rule the daily life of billions worldwide, as they are involved in obesity, depression and drug addiction. Consequently, there is growing interest to reveal novel active compounds in this field...
July 7, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28651693/fatty-acid-and-lipid-profiles-in-primary-human-trophoblast-over-90h-in-culture
#16
Véronique Ferchaud-Roucher, Michael C Rudolph, Thomas Jansson, Theresa L Powell
Little is known about the mechanisms underlying the preferential transport of long chain polyunsaturated fatty acids (LCPUFA) to the fetus by the syncytiotrophoblast and the role of cytotrophoblasts in placental lipid metabolism and transport. We studied primary human trophoblast (PHT) cells cultured for 90h to determine the fatty acid and lipid composition of cytotrophoblast (18h culture) and syncytiotrophoblast (90h culture) cells. In cultured PHT total lipid fatty acids were significantly (P < 0.05) reduced at 90h compared to 18h in culture including lower levels of palmitic acid (PA, 16:0, -37%), palmitoleic acid (POA, 16:1n-7, -30%), oleic acid (OA, 18:1n-9, -31%), LCPUFA arachidonic acid (AA, 20:4n-6, -28%) and α-linolenic acid (ALA, 18:3n-3, -55%)...
June 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28648567/eicosapentaenoic-and-docosahexaenoic-acids-have-different-effects-on-peripheral-phospholipase-a2-gene-expressions-in-acute-depressed-patients
#17
Kuan-Pin Su, Hui-Ting Yang, Jane Pei-Chen Chang, Yin-Hua Shih, Ta-Wei Guu, Satyanarayanan Senthil Kumaran, Piotr Gałecki, Anna Walczewska, Carmine M Pariante
INTRODUCTION: Omega-3 polyunsaturated fatty acids (PUFAs) have been proven critical in the development and management of major depressive disorder (MDD) by a number of epidemiological, clinical and preclinical studies, but the molecular mechanisms underlying this therapeutic action are yet to be understood. Although eicosapentaenoic acid (EPA) seems to be the active component of omega-3 PUFAs' antidepressant effects, the biological research about the difference of specific genetic regulations between EPA and docosahexaenoic acid (DHA), the two main components of omega-3 PUFAs, is still lacking in human subjects...
June 23, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28620184/transcriptomic-analysis-of-the-regulation-of-lipid-fraction-migration-and-fatty-acid-biosynthesis-in-schizochytrium-sp
#18
Lujing Ren, Xuechao Hu, Xiaoyan Zhao, Shenglan Chen, Yi Wu, Dan Li, Yadong Yu, Lingjun Geng, Xiaojun Ji, He Huang
Schizochytrium sp. is the main source of docosahexaenoic acid-rich oil, which is widely used in food additive and pharmaceutical industry. In this study, using RNA-seq, comparative transcriptomic analyses were performed at four stages of DHA fermentation by Schizochytrium sp to get potential genes related to cell transition from cell growth to lipid accumulation and then to lipid turnover. 1406, 385, 1384 differently expressed genes were identified by comparisons in pairs of S2 vs S1, S3 vs S2 and S4 vs S3...
June 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28484682/vitamin-c-transporters-in-cancer-current-understanding-and-gaps-in-knowledge
#19
REVIEW
Christina Wohlrab, Elisabeth Phillips, Gabi U Dachs
Sufficient uptake and whole body distribution of vitamin C (ascorbate) is essential for many biochemical processes, including some that are vital for tumor growth and spread. Uptake of ascorbate into cancer cells is modulated by availability, tumor blood flow, tissue diffusion parameters, and ascorbate transport proteins. Uptake into cells is mediated by two families of transport proteins, namely, the solute carrier gene family 23, consisting of sodium-dependent vitamin C transporters (SVCTs) 1 and 2, and the SLC2 family of glucose transporters (GLUTs)...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28427288/cigarette-smokers-develop-altered-erythrocyte-membrane-composition-an-investigation-unmasking-the-role-of-membrane-bound-integral-protein-glut-1
#20
Jyotirmoy Sikdar, Paromita Seal, Amartya Roy, Rajen Haldar
Erythrocytes in cigarette smokers are prone to oxidative damage. Here, we sought to elucidate the facts behind modifications and possible defense system developed in erythrocyte of cigarette smokers. We observed significant increase in stomatocytes and spherocytes, and osmotic fragility of erythrocyte, along with reduced level of protein thiol and increased fluorescence anisotropy in isolated membrane. Denaturing gel electrophoresis indicated alterations in band 3, band 4.2 and band 4.5. Among those, Glut 1 (i...
May 10, 2017: Free Radical Research
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