Julieta Lazarte, Zachary W Laksman, Jian Wang, John F Robinson, Jacqueline S Dron, Emma Leach, Janet Liew, Adam D McIntyre, Allan C Skanes, Lorne J Gula, Peter Leong-Sit, Henian Cao, Brett Trost, Stephen W Scherer, Robert A Hegele, Jason D Roberts
AIMS: Atrial fibrillation (AF) is a complex heritable disease whose genetic underpinnings remain largely unexplained, though recent work has suggested that the arrhythmia may develop secondary to an underlying atrial cardiomyopathy. We sought to evaluate for enrichment of loss-of-function (LOF) and copy number variants (CNVs) in genes implicated in ventricular cardiomyopathy in 'lone' AF. METHODS AND RESULTS: Whole-exome sequencing was performed in 255 early onset 'lone' AF cases, defined as arrhythmia onset prior to 60 years of age in the absence of known clinical risk factors...
June 7, 2021: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology