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Lone Atrial Fibrillation

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https://www.readbyqxmd.com/read/27861186/the-genetics-of-atrial-fibrillation
#1
Kenshi Hayashi, Hayato Tada, Masakazu Yamagishi
PURPOSE OF REVIEW: To describe recent findings regarding the role of rare and common genetic variants in atrial fibrillation. RECENT FINDINGS: Atrial fibrillation is associated with several clinical risk factors and its development is affected by genetic background. To date, rare variants from more than 30 genes have been identified from studies of familial cases or individuals with lone atrial fibrillation. In addition to using the candidate gene approach for the identification of rare variants, next-generation sequencing approaches such as genomic, whole exome and targeted sequencing have been employed...
January 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/27815140/transcutaneous-direct-current-cardioversion-in-a-foal-with-lone-atrial-fibrillation
#2
B M Potter, B A Scansen, L K Dunbar, S M Reed, R E Toribio
There are rare published reports of atrial fibrillation (AF) in foals, all of which are associated with structural heart disease or within the adaptive period of newborns. This report describes a 3-month-old Thoroughbred filly with AF and a structurally normal heart on echocardiography. Medical cardioversion of the foal's AF was attempted with three 20mg/kg doses of quinidine sulfate therapy without success. Timed, transcutaneous, direct current cardioversion was successfully performed using adhesive patches on the midthorax in conjunction with intravenous procainamide at a total dose of 20mg/kg...
November 1, 2016: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/27685438/atrioesophageal-fistula-after-minimally-invasive-video-assisted-epicardial-ablation-for-lone-atrial-fibrillation
#3
Charles Kik, Richard van Valen, Mostafa M Mokhles, Jos A Bekkers, Ad J J C Bogers
Minimally invasive video-assisted epicardial beating heart ablation for lone atrial fibrillation claims to be safe and effective. We, however, report on three patients with an atrioesophageal fistula after this procedure. The exact pathogenesis of this complication is unknown. All patients presented around 6 weeks after surgery with either fever or neurological deficits. Diagnosis can be made by computed tomography scan. We advocate an aggressive surgical approach with closure of the atrial defect on cardiopulmonary bypass and closure and reinforcement of the esophagus with an intercostal muscle flap in a single-stage surgery...
September 29, 2016: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/27630135/lone-atrial-fibrillation-is-associated-with-impaired-left-ventricular-energetics-that-persists-despite-successful-catheter-ablation
#4
Rohan S Wijesurendra, Alexander Liu, Christian Eichhorn, Rina Ariga, Eylem Levelt, William T Clarke, Christopher T Rodgers, Theodoros D Karamitsos, Yaver Bashir, Matthew Ginks, Kim Rajappan, Tim Betts, Vanessa M Ferreira, Stefan Neubauer, Barbara Casadei
BACKGROUND: Lone atrial fibrillation (AF) may reflect a subclinical cardiomyopathy that persists after sinus rhythm (SR) restoration, providing a substrate for AF recurrence. To test this hypothesis, we investigated the effect of restoring SR by catheter ablation on left ventricular (LV) function and energetics in patients with AF but no significant comorbidities. METHODS: Fifty-three patients with symptomatic paroxysmal or persistent AF and without significant valvular disease, uncontrolled hypertension, coronary artery disease, uncontrolled thyroid disease, systemic inflammatory disease, diabetes mellitus, or obstructive sleep apnea (ie, lone AF) undergoing ablation and 25 matched control subjects in SR were investigated...
October 11, 2016: Circulation
https://www.readbyqxmd.com/read/27624063/the-role-of-common-genetic-variants-in-atrial-fibrillation
#5
Christian Paludan-Müller, Jesper H Svendsen, Morten S Olesen
This review focuses on the genetic basis of atrial fibrillation (AF) and the role of variants in the susceptibility of developing the disease. AF is the most common cardiac arrhythmia affecting 1-2% of the general population. Studies in the last decade have demonstrated that AF, and in particular lone AF, has a substantial genetic component. A number of genome-wide association studies (GWAS) have indicated that common genetic variants, more precisely the so called single-nucleotide polymorphisms (SNPs) are associated with AF...
August 26, 2016: Journal of Electrocardiology
https://www.readbyqxmd.com/read/27594877/associations-of-big-endothelin-1-and-c-reactive-protein-in-atrial-fibrillation
#6
Li-Hui Zheng, Wei Sun, Yan Yao, Bing-Bo Hou, Yu Qiao, Shu Zhang
BACKGROUND: Atrial fibrillation (AF) is associated with inflammation and endothelial dysfunction. However, the association between inflammation (as indexed by high-sensitivity C-reactive protein, hs-CRP) and endothelial function [as indexed by big endothelin-1 (ET-1)] in AF patients remains unclear. METHODS: We enrolled 128 patients with lone AF, among which 83 had paroxysmal AF, and 45 had persistent AF. Eighty-two age- and gender-matched controls of paroxysmal supraventricular tachycardia without AF history were evaluated...
July 2016: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/27554047/relationship-between-vitamin-d-level-and-left-atrial-fibrosis-in-patients-with-lone-paroxysmal-atrial-fibrillation-undergoing-cryoballoon-based-catheter-ablation
#7
Uğur Canpolat, Kudret Aytemir, Tuncay Hazirolan, Necla Özer, Ali Oto
BACKGROUND: Left atrial (LA) fibrosis is known as the hallmark for arrhythmogenic substrate in atrial fibrillation (AF). Quantification of LA fibrosis by using delayed-enhanced magnetic resonance imaging (DE-MRI) in AF patients is a pioneering noninvasive technique. Vitamin D (vitD) negatively regulates the renin-angiotensin system, binds to vitD receptors on cardiac myocytes, and has antioxidant properties that may ameliorate the inflammation and proarrhythmic substrate formation. However, its role in LA fibrosis is unclear...
August 20, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/27547548/computational-fluid-dynamics-modelling-of-left-valvular-heart-diseases-during-atrial-fibrillation
#8
Stefania Scarsoglio, Andrea Saglietto, Fiorenzo Gaita, Luca Ridolfi, Matteo Anselmino
BACKGROUND: Although atrial fibrillation (AF), a common arrhythmia, frequently presents in patients with underlying valvular disease, its hemodynamic contributions are not fully understood. The present work aimed to computationally study how physical conditions imposed by pathologic valvular anatomy act on AF hemodynamics. METHODS: We simulated AF with different severity grades of left-sided valvular diseases and compared the cardiovascular effects that they exert during AF, compared to lone AF...
2016: PeerJ
https://www.readbyqxmd.com/read/27479212/common-variants-in-the-tbx5-gene-associated-with-atrial-fibrillation-in-a-chinese-han-population
#9
Rongfeng Zhang, Xiaochen Tian, Lianjun Gao, Huihua Li, Xiaomeng Yin, Yingxue Dong, Yanzong Yang, Yunlong Xia
BACKGROUND: PR interval variations have recently been associated with an increased risk of long-term atrial fibrillation (AF), heart block and all-cause mortality. Genome-wide association studies have linked the PR interval with several common variants in the TBX5 gene. Several variants in the TBX5 gene, including rs7312625 and rs883079, have been associated with AF. The purpose of this study was to determine the association of single-nucleotide polymorphisms (SNPs) in the TBX5 gene, rs7312625 and rs883079, with AF in Chinese Han patients...
2016: PloS One
https://www.readbyqxmd.com/read/27439924/-relationship-between-serum-level-of-cd40-ligand-and-persistent-lone-atrial-fibrillation
#10
Evin Bozçalı, Veli Polat, Gönül Kutlu, Selçuk Opan, Nurcan Paker, Turgut Uygun, Barış Ökçün, Osman Karakaya
OBJECTIVE: Inflammation is thought to play a role in the pathogenesis of atrial fibrillation. The relationship between CD40 ligand (CD40L), a prothrombotic and proinflammatory molecule, and lone atrial fibrillation was presently investigated for the first time. Levels of serum CD40L were also tested, regarding potential to distinguish patients with lone atrial fibrillation from healthy individuals. METHODS: Presently included were 35 patients with lone persistent atrial fibrillation and a control group of 30 healthy individuals...
July 2016: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/27439920/-serum-cd40-ligand-levels-and-persistent-lone-atrial-fibrillation
#11
EDITORIAL
Timuçin Altın
No abstract text is available yet for this article.
July 2016: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/27412960/a-comprehensive-insight-of-novel-antioxidant-therapies-for-atrial-fibrillation-management
#12
Esteban Orenes-Piñero, Mariano Valdés, Gregory Y H Lip, Francisco Marín
Atrial fibrillation (AF) is the most common arrhythmia in clinical practice and is associated with decreased quality of life, and increased mortality and morbidity from stroke and thromboembolism. The underlying mechanisms involved in the development of AF have yet to be fully elucidated. However, once initiated, AF tends to self-perpetuate, due to structural and electrical remodeling in the atria. Currently, therapies for AF, such as, antiarrhythmic drugs and catheter ablation, have significant limitations...
August 2015: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/27394409/association-between-heart-rate-at-rest-and-incident-atrial-fibrillation-from-the-copenhagen-electrocardiographic-study
#13
Morten W Skov, Troels N Bachmann, Peter V Rasmussen, Morten S Olesen, Adrian Pietersen, Claus Graff, Bent Lind, Johannes J Struijk, Lars Køber, Stig Haunsø, Jesper H Svendsen, Thomas A Gerds, Anders G Holst, Jonas B Nielsen
Heart rate (HR) at rest is a well-known marker of cardiovascular morbidity and mortality. Results on the association between HR and incident atrial fibrillation (AF) have, however, been conflicting. Using digital electrocardiograms from 281,451 primary care patients, we aimed to describe the association between HR at rest and the hazards of incident AF. Secondary end points were death from all causes and pacemaker implantation. Data on drug use, co-morbidity, and outcomes were collected from nationwide administrative health care registries...
September 1, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27359949/associations-between-physical-activity-and-atrial-fibrillation-is-resting-heart-rate-a-mediator-the-troms%C3%A3-study-806-board-122-june-1-2-00-pm-3-30-pm
#14
Bente Morseth, Sidsel Graff-Iversen, Bjarne K Jacobsen, Lone Jørgensen, Audhild Nyrnes, Dag S Thelle, Peter Vestergaard, Maja-Lisa Løchen
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27346453/association-of-genetic-variants-at-the-4q25-locus-with-atrial-fibrillation-in-indian-population
#15
Aparna Bhanushali, Akhil Nair, Ganesh Jagdale, Tilak Suvarna, Bibhu R Das
INTRODUCTION: Atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical settings known to impair cardiac function. Genome-wide association studies identified SNPs on chromosome 4q25 to be associated with AF. Till date no information is available from India related to the association of these variants with AF. MATERIALS AND METHODS: Two hundred and sixty-seven individuals comprising of 170 patients with Coronary Artery Disease (CAD), 41 patients with AF, and 56 healthy controls were genotyped for rs10033464 and rs2200733 at 4q25 locus...
June 27, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27345155/mechanistic-insights-into-mitral-regurgitation-due-to-atrial-fibrillation-atrial-functional-mitral-regurgitation
#16
Jackson J Liang, Frank E Silvestry
Mitral regurgitation (MR) is common, and definitive management of significant MR often requires percutaneous or surgical correction. Lone atrial fibrillation has been proposed to result in "atrial functional mitral regurgitation (AFMR)" via left atrial enlargement and mitral annular dilation. Patients with AFMR may represent a subgroup in which a rhythm control strategy may be preferred and catheter ablation is a promising nonsurgical therapy. This review discusses the anatomy of the mitral valve apparatus and MR classification schemes...
May 2, 2016: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27297859/atrial-fibrillation-without-comorbidities-prevalence-incidence-and-prognosis-from-the-framingham-heart-study
#17
Eun-Jeong Kim, Xiaoyan Yin, João D Fontes, Jared W Magnani, Steve A Lubitz, David D McManus, Sudha Seshadri, Ramachandran S Vasan, Patrick T Ellinor, Martin G Larson, Emelia J Benjamin, Michiel Rienstra
BACKGROUND: The epidemiology of atrial fibrillation (AF) without comorbidities, known as 'lone AF', is uncertain. Although it has been considered a benign condition, we hypothesized that it confers a worse prognosis compared with a matched sample without AF. METHODS: We described the proportion of AF without comorbidities (clinical, subclinical cardiovascular disease and triggers) among the entire AF sample in Framingham Heart Study (FHS). We compared AF without comorbidities with typical AF, and age-, sex- and cohort-matched individuals without AF, using Cox proportional hazards analysis in relation to combined cardiovascular events (stroke, heart failure, myocardial infarction), and mortality...
July 2016: American Heart Journal
https://www.readbyqxmd.com/read/27225323/radiofrequency-ablation-of-atrial-tachyarrhythmias-in-adults-with-tetralogy-of-fallot-predictors-of-success-and-outcome
#18
Vivienne A Ezzat, Matthew J Ryan, Justin O'Leary, Cono Ariti, John Deanfield, Bejal Pandya, Shay Cullen, Fiona Walker, Fakhar Khan, Dominic J Abrams, Pier D Lambiase, Martin D Lowe
BACKGROUND: Adults with tetralogy of Fallot experience atrial tachyarrhythmias; however, there are a few data on the outcomes of radiofrequency ablation. We examined the characteristics, outcome, and predictors of recurrence of atrial tachyarrhythmias after radiofrequency ablation in tetralogy of Fallot patients. Methods/results Retrospective data were collected from 2004 to 2013. In total, 56 ablations were performed on 37 patients. We identified two matched controls per case: patients with tetralogy of Fallot but no radiofrequency ablation and not known to have atrial tachyarrhythmias...
May 26, 2016: Cardiology in the Young
https://www.readbyqxmd.com/read/27076225/decreased-left-atrial-strain-parameters-are-correlated-with-prolonged-total-atrial-conduction-time-in-lone-atrial-fibrillation
#19
Chunyan Guo, Jiexin Liu, Shumei Zhao, Yixing Teng, Luhua Shen
To investigate left atrium (LA) strain properties of patients with lone atrial fibrillation (LAF) and to assess relationships between LA strain parameters and total atrial conduction time measured with tissue Doppler imaging (PA-TDI). The study population consisted of 53 patients with LAF. The control group was comprised of 50 normal volunteers. Conventional echocardiography indices were measured. Mitral annular velocities and PA-TDI were assessed with TDI. Two-dimensional speckle-tracking echocardiography (2D-STE) was used to assess LA segmental strain and strain rate...
July 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27026284/second-generation-cryoballoon-ablation-in-the-setting-of-lone-paroxysmal-atrial-fibrillation-single-procedural-outcome-at-12-months
#20
Valentina DE Regibus, Giacomo Mugnai, Darragh Moran, Burak Hünük, Erwin Ströker, Ebru Hacioglu, Diego Ruggiero, Hugo Enrique Coutiño-Moreno, Ken Takarada, Pedro Brugada, Carlo DE Asmundis, Gian-Battista Chierchia
BACKGROUND: Lone atrial fibrillation (LAF) develops in younger individuals without cardiovascular or pulmonary disease. As pulmonary vein isolation has been recognized as an optimal treatment for drug-resistant atrial fibrillation, cryoballoon ablation with second-generation balloon (CB-A) may be an ideal solution for LAF patients. OBJECTIVE: The aim of this study was to investigate acute success, periprocedural complications and outcome over a 12-month follow-up period in a cohort of patients having undergone PV isolation (PVI) for LAF using CB-A technology...
June 2016: Journal of Cardiovascular Electrophysiology
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