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Early Onset Atrial Fibrillation

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https://www.readbyqxmd.com/read/27909494/anemia-an-independent-predictor-of-adverse-outcomes-in-older-patients-with-atrial-fibrillation
#1
REVIEW
Ali N Ali MBChB MSc Mrcp Uk, Nandkishor V Athavale MBChB Md Frcp, Ahmed H Abdelhafiz MBChB MSc Md Frcp
Both anemia and atrial fibrillation are common in older people and their prevalence is age dependent which increases as population ages. Anemia, especially acute onset, predisposes to new onset atrial fibrillation which is likely to be mediated through inducing heart failure first and this predisposition seems to be potentiated by the presence of renal impairment. Anemia adds to the comorbidity burden of patients with atrial fibrillation and independently increases the risks of adverse outcomes such as increased hospitalization, mortality, bleeding and thromboembolic events...
April 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27892888/early-de-novo-atrial-fibrillation-after-coronary-artery-bypass-grafting-facts-and-features
#2
Ameeta Yaksh, Charles Kik, Paul Knops, Maarten J B van Ettinger, Ad J J C Bogers, Natasja M S de Groot
: Knowledge of the mechanism underlying post-operative atrial fibrillation (PoAF) is essential for development of preventive measures. The incidence and characteristics of both PoAF and supraventricular premature beats triggering PoAF, their interrelationship and alterations over time have never been examined. The goal of this study is therefore to examine the correlation between the incidence and characteristics of supraventricular premature beats (SVPBs) and PoAF episodes in patients undergoing CABG in the first five post-operative days...
November 10, 2016: American Heart Journal
https://www.readbyqxmd.com/read/27884663/early-impairment-in-left-ventricular-longitudinal-systolic-function-is-associated-with-an-increased-risk-of-incident-atrial-fibrillation-in-patients-with-type-2-diabetes
#3
Stefano Bonapace, Filippo Valbusa, Lorenzo Bertolini, Luciano Zenari, Guido Canali, Giulio Molon, Laura Lanzoni, Antonella Cecchetto, Andrea Rossi, Alessandro Mantovani, Giacomo Zoppini, Enrico Barbieri, Giovanni Targher
AIMS: It is known that type 2 diabetic patients are at high risk of atrial fibrillation (AF). However, the early echocardiographic determinants of AF vulnerability in this patient population remain poorly known. METHODS: We followed-up for 2years a sample of 180 consecutive outpatients with type 2 diabetes, who were free from AF and ischemic heart disease at baseline. All patients underwent a baseline echocardiographic-Doppler evaluation with tissue Doppler and 2-D strain analysis...
November 3, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27866651/cardiac-surgery-in-patients-with-previous-hepatic-or-renal-transplantation-a%C3%A2-pair-matched-study
#4
Mina Farag, Marina Nikolic, Rawa Arif, Bastian Schmack, Anton Sabashnikov, Mohamed Zeriouh, Aron-Frederik Popov, Arjang Ruhparwar, Matthias Karck, Alexander Weymann
BACKGROUND: The objective of this study was to compare outcomes of patients with previous solid organ transplant with those of a pair-matched population. METHODS: Data from our prospectively maintained cardiac surgery registry were obtained and identified 70 transplant recipients (21 hepatic, 49 renal) who were operated on at our department of cardiac surgery between 2000 and 2013; they formed the transplant group. Those patients were pair-matched regarding age, sex, and cardinal cardiac risk factors to form the pair-matched group...
November 17, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27863910/gabor-frames-for-classification-of-paroxysmal-and-persistent-atrial-fibrillation-episodes
#5
Nuria Ortigosa, Antonio Galbis, Carmen Fernández, Óscar Cano
In this study, we propose a new classification method for early differentiation of paroxysmal and persistent atrial fibrillation episodes, i.e. those which spontaneously or with external intervention will return to sinus rhythm within 7 days of onset from the ones where the arrhythmia is sustained for more than 7 days. Today, clinicians provide patients classification once the course of the arrhythmia has been disclosed. This classification problem is dealt with in this study. We study a sparse representation of surface electrocardiogram signals by means of Gabor frames and afterwards we apply a linear discriminant analysis...
November 15, 2016: Medical Engineering & Physics
https://www.readbyqxmd.com/read/27828845/early-effects-of-paroxysmal-atrial-fibrillation-on-plasma-markers-of-fibrinolysis
#6
Mariya Negreva, Svetoslav Georgiev, Katerina Vitlianova
There are no studies to date on the early changes in the hemostasis profile of patients with paroxysmal atrial fibrillation (PAF).Given the key role of the fibrinolytic system in maintaining blood fluidity, our aim was to examine its activity in patients with clinical manifestation of the disease <24 hours.We studied 51 nonanticoagulated patients with a first episode of the disease (26 men, 25 women; mean age 59.84 ± 1.60 years) and 52 controls (26 men, 26 women; mean age 59.50 ± 1.46 years) who matched the patients in terms of gender, age, comorbidities, and conducted treatment...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27828791/efficacy-and-safety-of-vernakalant-for-cardioversion-of-recent-onset-atrial-fibrillation-in-the-asia-pacific-region-a-phase-3-randomized-controlled-trial
#7
Gregory N Beatch, Kiran Bhirangi, Steen Juul-Moller, Jörg Rustige
Atrial fibrillation (AF) is a common clinically significant cardiac arrhythmia. This phase 3 randomized, double-blind, placebo-controlled trial assessed the efficacy and safety of vernakalant hydrochloride for the pharmacological conversion of AF to sinus rhythm (SR) in patients with recent-onset (>3 hours-≤7 days) symptomatic AF from the Asia-Pacific region. Patients received an infusion of vernakalant (3 mg/kg) or placebo over 10 minutes. If AF had not been terminated 15 minutes later, a second infusion of vernakalant (2 mg/kg) or placebo 15 minutes was administered...
November 7, 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27814760/clinical-predictors-of-seizure-recurrence-after-the-first-post-ischemic-stroke-seizure
#8
Hyeon Jin Kim, Kee Duk Park, Kyoung-Gyu Choi, Hyang Woon Lee
BACKGROUND: The number of patients suffering post-stroke seizure after ischemic stroke (PSSi) is quite considerable, especially because ischemic stroke is more prevalent than hemorrhage in the general population. This study aimed to determine the predicting factors for seizure recurrence in ischemic stroke survivors and develop a clinical scoring system for the prediction of risks for seizure recurrence after the first PSSi. METHODS: We reviewed 3792 ischemic stroke patients from the Ewha Stroke Registry...
November 5, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27809773/electrocardiographic-and-echocardiographic-predictors-of-paroxysmal-atrial-fibrillation-detected-after-ischemic-stroke
#9
Maria A Baturova, Seth H Sheldon, Jonas Carlson, Peter A Brady, Grace Lin, Alejandro A Rabinstein, Paul A Friedman, Pyotr G Platonov
BACKGROUND: Detection of atrial fibrillation after ischemic stroke is challenging due to its paroxysmal nature. We aimed to assess predictors of paroxysmal atrial fibrillation using non-invasive surface ECG and transthoracic echocardiography to select candidates for atrial fibrillation screening. METHODS: Ischemic stroke patients without documented atrial fibrillation (n = 110, 67 ± 10 years, 40 female) and a control group of age- and gender-matched patients with history of paroxysmal atrial fibrillation prior to stroke (n = 55, 67 ± 10 years, 19 female) comprised the study sample...
November 3, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27803121/new-onset-atrial-fibrillation-after-anatomic-lung-resection-predictive-factors-treatment-and-follow-up-in-a-uk-thoracic-centre
#10
Megan Garner, Tom Routledge, Juliet E King, John E Pilling, Lukacs Veres, Karen Harrison-Phipps, Andrea Bille, Leanne Harling
OBJECTIVES: Postoperative atrial fibrillation (POAF) increases morbidity, hospital stay and healthcare expenditure. This study aims to determine the perioperative factors correlating with POAF as well as to evaluate both treatment strategies and AF persistence beyond discharge. METHODS: The records of all patients undergoing anatomical lung resection over a 1-year period were retrospectively reviewed. Patients with a history of arrhythmia were excluded. POAF was defined by clinical diagnosis and electrocardiography...
November 1, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27795802/intravenous-thrombolysis-with-rt-pa-in-stroke-experience-of-the-moroccan-stroke-unit
#11
Naima Chtaou, Lamyae Rachdi, Aouatef El Midaoui, Zouhair Souirti, Nils Wahlgren, Mohammed Faouzi Belahsen
The majority of strokes are due to blockage of an artery in the brain by a blood clot. Prompt treatment with thrombolytic drugs can restore blood flow before major brain damage has occurred. We report the case series of all patients who were treated with rt-PA at Stroke Unit of HASSAN II University hospital between 2010 and 2013. There were 52 patients treated with intravenous rtPA during the study period. The mean age was 63 years with the no gender predominance (sex ratio 1.02). Hypertension was the most common vascular risk factor (31%) and 17% of patients suffered from atrial fibrillation...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27756709/gain-of-function-mutations-in-gata6-lead-to-atrial-fibrillation
#12
Nathan R Tucker, Saagar Mahida, Jiangchuan Ye, Elizabeth J Abraham, Julie A Mina, Victoria A Parsons, Michael A McLellan, Marisa A Shea, Alan Hanley, Emelia J Benjamin, David J Milan, Honghuang Lin, Patrick T Ellinor
BACKGROUND: The genetic basis of atrial fibrillation (AF) and congenital heart disease remains incompletely understood. OBJECTIVE: We sought to determine the causative mutation in a family with AF, atrial septal and ventricular septal defects. METHODS: We evaluated a pedigree with 16 family members, one with an atrial septal defect, one with a ventricular septal defect and three with AF; we performed whole exome sequencing in three affected family members...
October 15, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27753830/sy-03-3-overview-of-somatic-mutations-and-epigenetic-regulation-of-aldosterone-producing-adenoma-apa
#13
Satoshi Umemura
Primary aldosteronism (PA) is a heterogeneous group of disorders including both sporadic and familial forms (familial hyperaldosteronism type I, II and III). PA is the most frequent endocrine cause of secondary hypertension and associated with a higher rate of cardiovascular complications, compared with essential hypertension.Here I review the recent progress in understanding of the genetic and molecular mechanisms leading to autonomous aldosterone production in PA.Systematic screening detects primary aldosteronism in 5 to 10% of all patients with hypertension and in approximately 20% of patients with resistant hypertension...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27742809/a-frameshift-deletion-in-the-sarcomere-gene-myl4-causes-early-onset-familial-atrial-fibrillation
#14
Daniel F Gudbjartsson, Hilma Holm, Patrick Sulem, Gisli Masson, Asmundur Oddsson, Olafur Th Magnusson, Jona Saemundsdottir, Hafdis Th Helgadottir, Hannes Helgason, Hrefna Johannsdottir, Solveig Gretarsdottir, Sigurjon A Gudjonsson, Inger Njølstad, Maja-Lisa Løchen, Larry Baum, Ronald C W Ma, Gunnlaugur Sigfusson, Augustine Kong, Guðmundur Thorgeirsson, Jon Th Sverrisson, Unnur Thorsteinsdottir, Kari Stefansson, David O Arnar
AIMS: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in man, causing substantial morbidity and mortality with a major worldwide public health impact. It is increasingly recognized as a highly heritable condition. This study aimed to determine genetic risk factors for early-onset AF. METHODS AND RESULTS: We sequenced the whole genomes of 8453 Icelanders and imputed genotypes of the 25.5 million sequence variants we discovered into 1799 Icelanders with early-onset AF (diagnosed before 60 years of age) and 337 453 controls...
October 14, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27659151/trends-in-isolated-coronary-artery-bypass-grafting-over-the-last-decade
#15
Michel Kindo, Tam Hoang Minh, Stéphanie Perrier, Jonathan Bentz, Arnaud Mommerot, Philippe Billaud, Jean-Philippe Mazzucotelli
OBJECTIVES: The purpose of this study was to assess the impact on hospital mortality and morbidity of extensive myocardial revascularization, using arterial grafts in patients undergoing isolated coronary artery bypass grafting (CABG). METHODS: Our prospective perioperative database was used to define two groups of patients who underwent isolated CABG with cardiopulmonary bypass, based on the years in which the operation was performed: Group A (2000-2003; 898 patients) and Group B (2009-2012; 1249 patients)...
September 22, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27642883/sy-03-3-overview-of-somatic-mutations-and-epigenetic-regulation-of-aldosterone-producing-adenoma-apa
#16
Satoshi Umemura
Primary aldosteronism (PA) is a heterogeneous group of disorders including both sporadic and familial forms (familial hyperaldosteronism type I, II and III). PA is the most frequent endocrine cause of secondary hypertension and associated with a higher rate of cardiovascular complications, compared with essential hypertension.Here I review the recent progress in understanding of the genetic and molecular mechanisms leading to autonomous aldosterone production in PA.Systematic screening detects primary aldosteronism in 5 to 10% of all patients with hypertension and in approximately 20% of patients with resistant hypertension...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27624593/prognostic-value-of-left-atrial-strain-in-outpatients-with-de-novo-heart-failure
#17
Laura Sanchis, Rut Andrea, Carlos Falces, Teresa Lopez-Sobrino, Silvia Montserrat, Felix Perez-Villa, Bart Bijnens, Marta Sitges
BACKGROUND: Left atrial (LA) dysfunction has been related to symptom onset in patients with heart failure (HF). However, the potential prognostic role of LA function has been scarcely studied in outpatients with new-onset HF symptoms. METHODS: Consecutive outpatients with suspected HF onset evaluated at a one-stop clinic were screened. HF diagnosis was performed according to current guidelines. LA function was analyzed in patients in sinus rhythm by speckle-tracking echocardiography, determining LA peak strain rate after atrial contraction (LASRa) as a surrogate of atrial contractile function...
September 10, 2016: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/27600461/prognostic-significance-of-new-onset-atrial-fibrillation-in-patients-with-non-hodgkin-s-lymphoma-treated-with-anthracyclines
#18
Michitaka Amioka, Akinori Sairaku, Tetsuro Ochi, Takenori Okada, Hideki Asaoku, Taiichi Kyo, Yasuki Kihara
Cancer therapeutics-related cardiac dysfunction induced by anthracycline is highly problematic, and its early recognition is of importance. Atrial fibrillation (AF) is sometimes seen after anthracycline chemotherapy. We aimed to test whether new-onset AF predicts anthracycline-induced heart failure. We prospectively studied 249 lymphoma patients who received anthracyclines. The patients were followed up with a frequent electrocardiographic examination. Fifteen patients (6%) newly developed AF after the chemotherapy, and during a mean follow-up of 34 months, they had a higher incidence of acute heart failure (40% vs 3...
August 12, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27594874/predictors-of-new-onset-atrial-fibrillation-in-elderly-patients-with-coronary-artery-disease-after-coronary-artery-bypass-graft
#19
Rubanenko O Anatoĺevna, Fatenkov O Veniaminovich, Khokhlunov S Mikhaylovich
OBJECTIVE: To identify the factors associated with the development of postoperative atrial fibrillation (POAF) after coronary artery bypass graft (CABG) in elderly patients with coronary artery disease (CAD). METHODS: A total of 81 patients with CAD who underwent CABG were enrolled in the study. Patients were divided into two groups: Group 1, without postoperative atrial fibrillation (59 patients, 74.6% men, mean age 65.8 ± 4.0 years); Group 2, with early new-onset atrial fibrillation after CABG (22 patients, 90...
July 2016: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/27593538/usefulness-of-a-combination-of-interatrial-block-and-a-high-chads2-score-to-predict-new-onset-atrial-fibrillation
#20
Jin-Tao Wu, Shan-Ling Wang, Ying-Jie Chu, De-Yong Long, Jian-Zeng Dong, Xian-Wei Fan, Hai-Tao Yang, Hong-Yan Duan, Li-Jie Yan, Peng Qian, Chao-Kuan Yang
Interatrial block (IAB) is associated with an increased risk of atrial fibrillation (AF). The aim of this retrospective study was to investigate the association of a combination of IAB and the CHADS2 score, an AF-related risk score for ischemic stroke, with new onset AF in patients in sinus rhythm. A total of 1,571 patients (803 males, 768 females; mean age: 58 ± 16 years) were included in this study. IAB was defined as a P-wave duration > 120 ms in the 12-lead electrocardiogram, and a high CHADS2 score as ≥ 2 points...
September 28, 2016: International Heart Journal
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