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Early Onset Atrial Fibrillation

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https://www.readbyqxmd.com/read/29676832/circulating-mirnas-in-acute-new-onset-atrial-fibrillation-and-their-target-mrna-network
#1
Ananília Medeiros Gomes da Silva, Jéssica Nayara Góes de Araújo, Katiene Macêdo de Oliveira, Ana Eloísa Melo Novaes, Mariana Borges Lopes, Júlio César Vieira de Sousa, Antônio Amorim de Araújo Filho, André Ducati Luchessi, Adriana Augusto de Rezende, Mário Hiroyuki Hirata, Vivian Nogueira Silbiger
BACKGROUND: MicroRNAs (miRNAs) are involved in the pathogenesis of atrial fibrillation (AF), acting on development and progression. Our pilot study investigated the expression of six miRNAs and their miRNA-mRNA interactions in patients with acute new-onset AF, well-controlled AF, and normal sinus rhythm (controls). METHODS AND RESULTS: Plasma of acute new-onset AF patients (n = 5) was collected in the emergency room when patients presented with irregular and fast-atrial fibrillation rhythm...
April 20, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29665154/development-and-validation-of-a-risk-stratification-score-for-new-onset-atrial-fibrillation-in-stemi-patients-undergoing-primary-percutaneous-coronary-intervention
#2
Annamaria Mazzone, Marco Scalese, Umberto Paradossi, Serena Del Turco, Nicoletta Botto, Alberto De Caterina, Giuseppe Trianni, Marcello Ravani, Antonio Rizza, Sabrina Molinaro, Cataldo Palmieri, Sergio Berti, Giuseppina Basta
AIM: New-onset atrial fibrillation (NOAF) is a complication not infrequent in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) and has been associated with worse in-hospital and long-term prognosis. We aimed to develop and validate a risk score based on common clinical risk factors and routine blood biomarkers to assess the early incidence of NOAF post-pPCI, before discharge. METHODS: The risk score for NOAF occurrence during hospitalisation (about 5 days) was developed in a cohort of 1135 consecutive STEMI patients undergoing pPCI while was externally validated in a temporal cohort of 771 STEMI patients...
April 17, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29657061/risk-factors-for-new-onset-atrial-fibrillation-a-focus-on-asian-populations
#3
Yanguang Li, Daniele Pastori, Yutao Guo, Yutang Wang, Gregory Y H Lip
The incidence of new-onset atrial fibrillation (NOAF) is increasing both in the Asian populations and Western countries. Several demographic and clinical risk factors were independently associated with NOAF, including ageing, male sex, obesity, obstructive sleep apnea syndrome, hypertension, coronary artery disease, renal dysfunction and heart failure. However, some differences in the incidence of NOAF, the prevalence of some risk factors and lifestyle or environmental conditions may exist between Asian and Western countries...
June 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29571870/characteristics-of-the-ischemic-stroke-patients-whose-seizures-occur-at-stroke-presentation-at-a-single-institution-in-eastern-china
#4
Jian-Hua Cheng, Zheng Zhang, Qiang Ye, Zu-Sen Ye, Nian-Ge Xia
PURPOSE: We compared clinical characteristics and outcomes of the early-onset seizure post-stroke patients who had seizures occurring at stroke presentation (SSP) with other patients without SSP at a single institution in Eastern China. METHODS: We reviewed 20,947 ischemic stroke patients in our hospital electronic medical records system from January 2007 to December 2016. Among them, there were 91 (0.43%) patients with early-onset seizure post-stroke. Among these 91 patients, there were 35 (0...
April 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29571846/neutrophil-to-lymphocyte-ratio-and-early-clinical-outcomes-in-patients-with-acute-ischemic-stroke
#5
Sungwook Yu, Hisatomi Arima, Carin Bertmar, Stephen Clarke, Geoffrey Herkes, Martin Krause
BACKGROUND: The neutrophil to lymphocyte ratio (NLR) is closely linked to mortality in patients with cardiovascular disease. We investigated whether NLR is associated with early clinical outcomes in patients with acute ischemic stroke. METHODS: We collated data from a tertiary hospital's stroke registry including admitted patients with a first-ever acute ischemic stroke within 72 h of onset. White blood cell counts and peripheral differential counts were measured on admission...
April 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29571030/prediction-of-new-onset-atrial-fibrillation-after-first-ever-ischemic-stroke-a-comparison-of-chads-2-cha-2-ds-2-vasc-and-hatch-scores-and-the-added-value-of-stroke-severity
#6
Cheng-Yang Hsieh, Cheng-Han Lee, Darren Philbert Wu, Sheng-Feng Sung
BACKGROUND AND AIMS: Early detection of atrial fibrillation after stroke is important for secondary prevention in stroke patients without known atrial fibrillation (AF). We aimed to compare the performance of CHADS2 , CHA2 DS2 -VASc and HATCH scores in predicting AF detected after stroke (AFDAS) and to test whether adding stroke severity to the risk scores improves predictive performance. METHODS: Adult patients with first ischemic stroke event but without a prior history of AF were retrieved from a nationwide population-based database...
March 15, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29490874/risk-factors-for-the-development-of-incident-atrial-fibrillation-in-patients-with-cardiac-implantable-electronic-devices
#7
Kazuo Miyazawa, Yusuke Kondo, Miyo Nakano, María Asunción Esteve-Pastor, José Miguel Rivera-Caravaca, Keitaro Senoo, Yoshio Kobayashi, Gregory Y H Lip
INTRODUCTION: Cardiac implantable electronic devices (CIEDs) can detect atrial fibrillation (AF) early and accurately. Risk factors for the development of new-onset AF in patients with CIEDs remains uncertain. METHODS: Patients with CIEDs who visited Chiba University Hospital between January 2016 and December 2016 were enrolled. We only included patients without single chamber CIEDs or a known history of AF. RESULTS: Of 371 patients with CIEDs, 78 (21...
February 26, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29490322/updates-in-stroke-treatment
#8
Brian Mac Grory, Shadi Yaghi
In this article, we discuss major advances in the treatment and prevention of ischemic stroke that have taken placed in the past 3 years. The most important advance in acute stroke treatment is the validation and widespread adoption of intra-arterial therapies for the treatment of acute ischemic stroke. Five clinical trials spanning multiple continents were published in early 2015 that proved that intra-arterial treatment - both with and without tPA - is beneficial in improving functional recovery after stroke...
March 1, 2018: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/29481591/effect-of-new-onset-atrial-fibrillation-on-cause-specific-late-mortality-after-coronary-artery-bypass-grafting-surgery
#9
Thomas A Schwann, Laila Al-Shaar, Milo C Engoren, Mark R Bonnell, Matthew Goodwin, Alexandra N Schwann, Robert H Habib
OBJECTIVES: Postoperative atrial fibrillation (POAF) is a common complication after coronary artery bypass grafting. Although transient, POAF is linked to increased late mortality. We hypothesized that POAF increases late cerebrovascular (CeV) and composite cerebrovascular/cardiovascular/vascular (CV* = CeV + CV + Other-V) but not non-cardiovascular (Non-CV) mortality. METHODS: We analysed 8807 non-salvage coronary artery bypass grafting patients (1994-2011)...
February 21, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29410336/initial-attempt-to-select-patients-for-mechanical-thrombectomy-using-non-contrast-computed-tomography-and-symptom-based-criteria-single-center-experience
#10
Satoshi Koizumi, Toshikazu Kimura, Masaaki Shojima, Tomohiro Inoue
BACKGROUND: In the treatment of acute ischemic stroke (AIS), patients need to be selected for mechanical thrombectomy (MT) in the acute phase. Selection criteria vary, however, depending on the patient's situations. This study investigated the effectiveness of a non-contrast computed tomography (NCCT) and a symptom-based protocol for selecting patients for MT. METHODS: This retrospective study included 20 AIS patients. The first 8 patients (earlier group) were screened by magnetic resonance imaging (MRI)...
February 1, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29383177/a-novel-kcnd3-mutation-associated-with-early-onset-lone-atrial-fibrillation
#11
Yuan Huang, Jiawei Yang, Wanyi Xie, Qince Li, Zhipeng Zeng, Haibo Sui, Zhonggui Shan, Zhengrong Huang
Atrial fibrillation (AF) is the most common arrhythmia in the clinic. While previous studies have identified AF-associated mutations in several genes, the genetic basis for AF remains unclear. Here, we identified a novel T361S missense mutation in potassium voltage-gated channel, shal-related subfamily, member 3 (KCND3) from a Chinese Han family ancestor with lone AF. The wild-type (WT) or mutant T361S of Kv4.3 protein (encoded by KCND3) were co-expressed with the auxiliary subunit K+ channel-Interacting Protein (KChIP2) in HEK293 cells, and transient outward potassium current (Ito) were recorded using patch-clamp methods, and the surface or total protein levels of Kv4...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29275952/late-onset-of-atrial-fibrillation-in-patients-undergoing-mitral-valve-repair-for-type-ii-dysfunction
#12
Naonori Kawamoto, Tomoyuki Fujita, Satsuki Fukushima, Yusuke Shimahara, Yuta Kume, Yorihiko Matsumoto, Kizuku Yamashita, Junjiro Kobayashi
BACKGROUND: There are few reports regarding factors related to late-onset of atrial fibrillation (Af) after mitral valve repair, which can compromise long-term outcome. We analyzed the risk factors for late Af after mitral valve repair. METHODS AND RESULTS: Between 2001 and 2015, 318 patients (214 males; median, 57.7 years) underwent mitral valve repair for degenerative mitral insufficiency (MI) without concomitant aortic valve disease in our institute. Patients with a history of paroxysmal or chronic Af preoperatively were excluded...
April 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29273767/the-rs2108622-polymorphism-is-related-to-the-early-risk-of-ischemic-stroke-in-non-valvular-atrial-fibrillation-subjects-under-oral-anticoagulation
#13
L Colàs-Campàs, J L Royo, M V Montserrat, C Marzo, J Molina-Seguín, I Benabdelhak, S Cambray, F Purroy
Oral anticoagulant treatments, such as vitamin K antagonists (VKAs), are the main treatments administered to atrial fibrillation (AF) patients in order to prevent ischemic stroke (IS). However, the genes involved in the VKA metabolism can undergo variations in a single nucleotide (SNP). These SNPs may then affect the VKA target enzyme (VKORC1), VKA degradation enzyme (CYP2C9), and vitamin K bioavailability enzyme (CYP4F2). We genotyped these SNPs in a cohort of patients with non-valvular AF who were under VKA treatment after suffering an IS...
December 22, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/29260030/pre-stroke-glycemic-control-is-associated-with-early-neurologic-deterioration-in-acute-atrial-fibrillation-related-ischemic-stroke
#14
J-S Kim, R-Y Kim, J-K Cha, H W Rha, M-J Kang, D-H Kim, H-S Park, J-H Choi, J-T Huh, I-K Lee
Background: It has been suggested that AF-related ischemic stroke (IS) that is accompanied by atherosclerotic burden have poorer outcomes. The aim of this study was to investigate the importance of pre-stroke glycemic control (PSGC) on the early neurologic deterioration (END) of patients with acute AF-related IS. Methods: We retrospectively recruited 121 patients with AF-related IS who also had Diabetes mellitus (DM). The HbA1C level was measured in all subjects...
September 2017: ENeurologicalSci
https://www.readbyqxmd.com/read/29250223/california-study-of-ablation-caabl-early-utilization-after-index-hospitalization-for-non-valvular-atrial-fibrillation
#15
Uma Srivatsa, Beate Danielsen, Ezra Amsterdam, Yingbo Yang, Dali Fan, Nayereh Pezeshkian, Richard H White
Background: Catheter ablation (ABL) for non-valvular AF (NVAF) is recommended for symptomatic patients refractory to medical therapy and its success is related to the duration of the arrhythmia prior to intervention.Our aim was to assess the early utilization and the factors that prompted ABL in patients hospitalized for new onset NVAF. Methods: Using de-identified administrative discharge records for hospitalizations and emergency department (ED) visits, we determined the patients who had a first-time (since 1991) health record diagnosis of AF between2005 - 2011...
June 2017: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/29237688/heritability-of-atrial-fibrillation
#16
Lu-Chen Weng, Seung Hoan Choi, Derek Klarin, J Gustav Smith, Po-Ru Loh, Mark Chaffin, Carolina Roselli, Olivia L Hulme, Kathryn L Lunetta, Josée Dupuis, Emelia J Benjamin, Christopher Newton-Cheh, Sekar Kathiresan, Patrick T Ellinor, Steven A Lubitz
BACKGROUND: Previous reports have implicated multiple genetic loci associated with AF, but the contributions of genome-wide variation to AF susceptibility have not been quantified. METHODS AND RESULTS: We assessed the contribution of genome-wide single-nucleotide polymorphism variation to AF risk (single-nucleotide polymorphism heritability, h 2 g ) using data from 120 286 unrelated individuals of European ancestry (2987 with AF) in the population-based UK Biobank...
December 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/29237675/gene-based-risk-stratification-for-cardiac-disorders-in-lmna-mutation-carriers
#17
Suguru Nishiuchi, Takeru Makiyama, Takeshi Aiba, Kenzaburo Nakajima, Sayako Hirose, Hirohiko Kohjitani, Yuta Yamamoto, Takeshi Harita, Mamoru Hayano, Yimin Wuriyanghai, Jiarong Chen, Kenichi Sasaki, Nobue Yagihara, Taisuke Ishikawa, Kenji Onoue, Nobuyuki Murakoshi, Ichiro Watanabe, Kimie Ohkubo, Hiroshi Watanabe, Seiko Ohno, Takahiro Doi, Satoshi Shizuta, Tohru Minamino, Yoshihiko Saito, Yasushi Oginosawa, Akihiko Nogami, Kazutaka Aonuma, Kengo Kusano, Naomasa Makita, Wataru Shimizu, Minoru Horie, Takeshi Kimura
BACKGROUND: Mutations in LMNA ( lamin A/C ), which encodes lamin A and C, typically cause age-dependent cardiac phenotypes, including dilated cardiomyopathy, cardiac conduction disturbance, atrial fibrillation, and malignant ventricular arrhythmias. Although the type of LMNA mutations have been reported to be associated with susceptibility to malignant ventricular arrhythmias, the gene-based risk stratification for cardiac complications remains unexplored. METHODS AND RESULTS: The multicenter cohort included 77 LMNA mutation carriers from 45 families; cardiac disorders were retrospectively analyzed...
December 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/29197413/timing-of-oral-anticoagulant-therapy-in-acute-ischemic-stroke-with-atrial-fibrillation-study-protocol-for-a-registry-based-randomised-controlled-trial
#18
Signild Åsberg, Ziad Hijazi, Bo Norrving, Andreas Terént, Patrik Öhagen, Jonas Oldgren
BACKGROUND: Oral anticoagulation therapy is recommended for the prevention of recurrent ischemic stroke in patients with atrial fibrillation (AF). Current guidelines do not provide evidence-based recommendations on optimal time-point to start anticoagulation therapy after an acute ischemic stroke. Non-vitamin K antagonist oral anticoagulants (NOACs) may offer advantages compared to warfarin because of faster and more predictable onset of action and potentially a lower risk of intracerebral haemorrhage also in the acute phase after an ischemic stroke...
December 2, 2017: Trials
https://www.readbyqxmd.com/read/29161419/incidence-of-postoperative-atrial-fibrillation-recurrence-in-patients-discharged-in-sinus-rhythm-after-cardiac-surgery-a-systematic-review-and-meta-analysis
#19
Nicole Lowres, Georgina Mulcahy, Kai Jin, Robyn Gallagher, Lis Neubeck, Ben Freedman
Postoperative atrial fibrillation (POAF) is associated with increased stroke risk and mortality post-discharge. POAF is often considered transient; however, recurrence is likely under-recognized as symptoms are an unreliable guide. Surveillance post-discharge may identify asymptomatic POAF recurrences in patients discharged in sinus rhythm. Therefore, we performed a systematic review and meta-analysis of studies investigating POAF recurrence post-discharge, in patients with new-onset POAF following cardiac surgery who reverted to sinus rhythm prior to discharge...
November 17, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29107160/resumption-of-antithrombotic-agents-in-chronic-subdural-hematoma-a-systematic-review-and-meta-analysis
#20
REVIEW
Kevin Phan, David Abi-Hanna, Jack Kerferd, Victor M Lu, Adam A Dmytriw, Yam-Ting Ho, Jacob Fairhall, Rajesh Reddy, Peter Wilson
BACKGROUND: The clinical decision whether and when to resume antithrombotics in patients with chronic subdural hematomas (CSDH) postoperatively is limited by a lack of quality evidence exploring this topic. Our study aims to assess the available evidence of patient complication outcomes, specifically hemorrhagic and thromboembolic events, following the resumption or non-resumption of antithrombotic agents postoperatively in CSDH patients already on these agents before CSDH. METHODS: We followed recommended PRISMA guidelines for systematic reviews...
January 2018: World Neurosurgery
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