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https://www.readbyqxmd.com/read/29755127/a-novel-long-non-coding-rna-linc-znf469-3-promotes-lung-metastasis-through-mir-574-5p-zeb1-axis-in-triple-negative-breast-cancer
#1
Po-Shun Wang, Cheng-Han Chou, Cheng-Han Lin, Yun-Chin Yao, Hui-Chuan Cheng, Hao-Yi Li, Yu-Chung Chuang, Chia-Ning Yang, Luo-Ping Ger, Yu-Chia Chen, Forn-Chia Lin, Tang-Long Shen, Michael Hsiao, Pei-Jung Lu
Triple-negative breast cancer (TNBC) patients usually lead to poor prognosis and survival because of metastasis. The major sites for TNBC metastasis include the lungs, brain, liver, and bone. Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts longer than 200 nucleotides and have been reported as important regulators in BC metastasis. However, the underlying mechanisms for lncRNAs regulating TNBC metastasis are not fully understood. Here we found that linc-ZNF469-3 was highly expressed in lung-metastatic LM2-4175 TNBC cells and overexpression of linc-ZNF469-3 enhanced invasion ability and stemness properties in vitro and lung metastasis in vivo...
May 14, 2018: Oncogene
https://www.readbyqxmd.com/read/29658958/treatment-with-src-inhibitor-dasatinib-results-in-elevated-metastatic-potential-in-the-4t1-murine-mammary-carcinoma-model
#2
Veronica S Hughes, Dietmar W Siemann
Introduction: The src inhibitor Dasatinib has been widely studied as an anti-metastatic agent. The aims of this study were to examine the effect of Src inhibition on the metastatic potential of the 4T1 murine mammary carcinoma. Context: Src is a non-receptor tyrosine kinase well-known to contribute to the metastatic potential of tumour cells. It does so through alteration of signalling pathways important to metastasis. Elevated levels of Src are common in many cancer types, and have been correlated with tumour progression and poor patient prognosis...
2018: Tumor & microenvironment
https://www.readbyqxmd.com/read/29626045/effect-of-emotional-content-on-online-video-sharing-among-health-care-professionals-and-researchers-diffusion-results-and-lessons-learnt-from-a-randomised-controlled-trial
#3
Junko Kiriya, Phil Edwards, Ian Roberts
OBJECTIVES: We assessed the effect of emotional content on the extent to which online videos are shared among health professionals. SETTING: We conducted a two-arm randomised controlled trial. We sent a link to one of two videos by email to participants asking them to watch the video and forward it to their colleagues. PARTICIPANTS: Health professionals and researchers (obstetrics, gynaecology and midwifery) with an email address apart from those in countries where access to YouTube is banned...
April 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29396489/increased-risk-of-coronary-heart-disease-among-patients-with-primary-sj%C3%A3-gren-s-syndrome-a-nationwide-population-based-cohort-study
#4
Xue-Fen Wu, Jing-Yang Huang, Jeng-Yuan Chiou, Huang-Hsi Chen, James Cheng-Chung Wei, Ling-Li Dong
To investigate the association between primary Sjögren's syndrome (pSS) and coronary heart disease (CHD), and the influence of medications for pSS patients on risk of CHD. The authors identified 4175 patients with a new diagnosis of pSS between 2002 and 2013 from the National Health Insurance Research database. The control-to-case ratio was 4:1. The risk and cumulative incidences of CHD were calculated. The adjusted hazard ratio (HR) of CHD for pSS patients was 1.17 (1.03-1.34) after adjusting for age, sex, comorbidities, and medications...
February 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29382402/associations-of-physical-activity-with-anxiety-symptoms-and-status-results-from-the-irish-longitudinal-study-on-ageing
#5
C P McDowell, B R Gordon, K L Andrews, C MacDonncha, M P Herring
AIMS: Anxiety is debilitating and associated with numerous mental and physical comorbidities. There is a need to identify and investigate low-risk prevention and treatment strategies. Therefore, the purpose of this study was to investigate cross-sectional and longitudinal associations between different volumes of moderate-to-vigorous physical activity (PA) and anxiety symptoms and status among older adults in Ireland. METHODS: Participants (n = 4175; 56.8% female) aged ⩾50 years completed the International PA Questionnaire (IPAQ) at baseline, and the anxiety subscale of the Hospital Anxiety and Depression Scale at baseline and follow-up (2009-2013)...
January 31, 2018: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/29345927/embedded-multireference-coupled-cluster-theory
#6
David J Coughtrie, Robin Giereth, Daniel Kats, Hans-Joachim Werner, Andreas Köhn
Internally contracted multireference coupled cluster (icMRCC) theory is embedded within multireference perturbation theory (MRPT) to calculate energy differences in large strongly correlated systems. The embedding scheme is based on partitioning the orbital spaces of a complete active space self-consistent field (CASSCF) wave function, with a truncated virtual space constructed by transforming selected projected atomic orbitals (PAOs). MRPT is applied to the environment using a subtractive embedding approach that also allows for multilayer embedding...
February 13, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29297951/study-of-the-utility-and-problems-of-common-iliac-artery-balloon-occlusion-for-placenta-previa-with-accreta
#7
Yoshihisa Ono, Yoshihiko Murayama, Sumiko Era, Shigetaka Matsunaga, Tomonori Nagai, Hisato Osada, Yasushi Takai, Kazunori Baba, Satoru Takeda, Hiroyuki Seki
AIMS: We investigated whether common iliac artery balloon occlusion (CIABO) was effective for decreasing blood loss during cesarean hysterectomy (CH) in patients with placenta previa with accreta and was safe for mothers and fetuses. METHODS: Of the 67 patients who underwent CH for placenta previa with accreta at our facility from 1985 to 2014, 57 patients were eligible for the study. The amount of intraoperative bleeding during CH was compared between three groups: surgery without blood flow occlusion (13 patients), internal iliac artery ligation (15 patients) and CIABO (29 patients)...
March 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29261249/real-world-economic-value-of-a-21-gene-assay-in-early-stage-breast-cancer
#8
Stanley E Waintraub, Donna McNamara, Deena Mary Atieh Graham, Andrew L Pecora, John Min, Tommy Wu, Hyun Gi Noh, Jacqueline Connors, Ruth Pe Benito, Kelly Choi, Eric Schultz, Stuart L Goldberg
OBJECTIVES: Value-based payment reforms shift cost-containment responsibilities to the physician. Although gene expression profiling (GEP) utilizing a 21-gene panel among patients with early-stage, axillary lymph node-negative, hormone receptor-positive, HER2/neu oncogene-negative breast cancer is able to identify a cohort that may achieve excellent outcomes without adjuvant chemotherapy, high up-front costs (list price, $4175) could dissuade usage. STUDY DESIGN: Retrospective review of consecutive patients with breast cancer treated at a single cancer center...
December 1, 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28939714/kidney-disease-measures-and-left-ventricular-structure-and-function-the-atherosclerosis-risk-in-communities-study
#9
Kunihiro Matsushita, Lucia Kwak, Yingying Sang, Shoshana H Ballew, Hicham Skali, Amil M Shah, Josef Coresh, Scott Solomon
BACKGROUND: Heart failure is one of the most important complications of chronic kidney disease (CKD). However, few studies comprehensively investigated left ventricular (LV) structure and function in relation to 2 key CKD measures, estimated glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (ACR). METHODS AND RESULTS: Among 4175 ARIC (Atherosclerosis Risk in Communities) participants (aged 66-90 years during 2011-2013), we quantified the association of eGFR and ACR with echocardiogram parameters of LV mass, size, systolic function, and diastolic function...
September 22, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28923096/maternal-health-research-outputs-and-gaps-in-latin-america-reflections-from-the-mapping-study
#10
Emily Vargas-Riaño, Víctor Becerril-Montekio, Francisco Becerra-Posada, Mario Tristán
As part of the MASCOT/WOTRO multinational team conducting the maternal health literature mapping, four Latin American researchers were particularly interested in analysing information specific to their region. The mapping started with 45,959 papers uploaded from MEDLINE, CINAHL, Embase, LILACAS, PopLINE, PsycINFO and Web of Knowledge. From these, 4175 full texts were reviewed and 2295 papers were subsequently included. Latin America experienced an average maternal mortality decline of 40% between 1990 and 2013...
September 18, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28549381/cervical-cancer-screening-in-rural-mountainous-honduras-knowledge-attitudes-and-barriers
#11
Rachel J Pryor, Nadia Masroor, Michael Stevens, Kakotan Sanogo, Pedro José Hernández O'Hagan, Gonzalo Bearman
INTRODUCTION: Because cervical cancer is the leading cause of cancer mortality in Honduras, this study assessed knowledge, attitudes and barriers to cervical cancer screening services by Papanicolaou smear (pap smear) for women in rural, remote Honduras served by Virginia Commonwealth University's Global Health and Health Disparities Program (GH2DP). METHODS: Two interviewers administered an institutional review board approved, 20 question survey by convenience sample methodology to adult female patients visiting GH2DP clinics in June 2014...
April 2017: Rural and Remote Health
https://www.readbyqxmd.com/read/28512489/effect-of-deep-cryogenic-treatment-on-cyclic-fatigue-of-endodontic-rotary-nickel-titanium-instruments
#12
Mohammad Yazdizadeh, Masoumeh Skini, Seyyed Mohsen Hoseini Goosheh, Mansour Jafarzadeh, Milad Shamohammadi, Vahid Rakhshan
INTRODUCTION: Cyclic fatigue is the common reason for breakage of rotary instruments. This study was conducted to evaluate the effect of cryogenic treatment (CT) in improving the resistance to cyclic fatigue of endodontic rotary instruments. METHODS AND MATERIALS: In this in vitro study, 20 RaCe and 20 Mtwo files were randomly divided into two groups of negative control and CT. CT files were stored in liquid nitrogen at -196(°)C for 24 h, and then were gradually warmed to the room temperature...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28215269/is-there-an-association-between-short-sleep-duration-and-adolescent-anxiety-disorders
#13
Robert E Roberts, Hao T Duong
OBJECTIVE: The purpose of this study is to provide the first data on the prospective, reciprocal association between short sleep duration and DSM-IV anxiety disorders among adolescents. METHODS: A community-based two-wave cohort study included 4175 youths aged 11-17 years at baseline, with 3134 of these followed up a year later, drawn from a metropolitan area with a population of over 4 million. Anxiety is defined as any DSM-IV anxiety disorder in the past year generalized anxiety: panic disorder, agoraphobia without panic, social phobia, and post-traumatic stress disorder...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28182250/determinants-of-the-recommended-phase-2-dose-of-molecular-targeted-agents
#14
Aaron R Hansen, Natalie Cook, Eitan Amir, Lillian L Siu, Albiruni Ryan Abdul Razak
BACKGROUND: The recommended phase 2 dose (RP2D) of anticancer agents is determined traditionally by dose-limiting toxicities. Nontoxicity or biological endpoints such as pharmacokinetics, pharmacodynamics, and efficacy can also be used to identify RP2D, which may be relevant to molecularly targeted agents (MTAs). METHODS: A systematic review identified all monotherapy phase 1 studies of MTAs in solid tumors published between 2001 and 2013. Dose, dosing schedule, and determinants of RP2D were collected from each study...
April 15, 2017: Cancer
https://www.readbyqxmd.com/read/28173823/effectiveness-of-a-clinical-practice-change-intervention-in-increasing-the-provision-of-nicotine-dependence-treatment-in-inpatient-psychiatric-facilities-an-implementation-trial
#15
Paula M Wye, Emily A Stockings, Jenny A Bowman, Chris Oldmeadow, John H Wiggers
BACKGROUND: Despite clinical practice guidelines recommending the routine provision of nicotine dependence treatment to smokers in inpatient psychiatric facilities, the prevalence of such treatment provision is low. The aim of this study was to examine the effectiveness of a clinical practice change intervention in increasing clinician recorded provision of nicotine dependence treatment to patients in inpatient psychiatric facilities. METHODS: We undertook an interrupted time series analysis of nicotine dependence treatment provision before, during and after a clinical practice change intervention to increase clinician recorded provision of nicotine dependence treatment for all hospital discharges (aged >18 years, N = 4175) over a 19 month period in two inpatient adult psychiatric facilities in New South Wales, Australia...
February 7, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28157707/near-infrared-fluorescent-imaging-of-choline-kinase-alpha-expression-and-inhibition-in-breast-tumors
#16
Sean P Arlauckas, Manoj Kumar, Anatoliy V Popov, Harish Poptani, Edward J Delikatny
Choline kinase alpha (ChoKα) overexpression is associated with an aggressive tumor phenotype. ChoKα inhibitors induce apoptosis in tumors, however validation of their specificity is difficult in vivo. We report the use of optical imaging to assess ChoKα status in cells and in vivo using JAS239, a carbocyanine-based ChoKα inhibitor with inherent near infrared fluorescence. JAS239 attenuated choline phosphorylation and viability in a panel of human breast cancer cell lines. Antibody blockade prevented cellular retention of JAS239 indicating direct interaction with ChoKα independent of the choline transporters and catabolic choline pathways...
March 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28096694/luteolin-inhibits-lung-metastasis-cell-migration-and-viability-of-triple-negative-breast-cancer-cells
#17
Matthew T Cook, Yayun Liang, Cynthia Besch-Williford, Salman M Hyder
Most breast cancer-related deaths from triple-negative breast cancer (TNBC) occur following metastasis of cancer cells and development of tumors at secondary sites. Because TNBCs lack the three receptors targeted by current chemotherapeutic regimens, they are typically treated with extremely aggressive and highly toxic non-targeted treatment strategies. Women with TNBC frequently develop metastatic lesions originating from drug-resistant residual cells and have poor prognosis. For this reason, novel therapeutic strategies that are safer and more effective are sought...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28025662/the-effect-of-a-live-high-train-high-exercise-regimen-on-behavioural-temperature-regulation
#18
RANDOMIZED CONTROLLED TRIAL
Shawnda A Morrison, Urša Ciuha, Daniela Zavec-Pavlinić, Ola Eiken, Igor B Mekjavic
PURPOSE: Acute hypoxia alters the threshold for sensation of cutaneous thermal stimuli. We hypothesised that hypoxia-induced alterations in cutaneous temperature sensation may lead to modulation of the perception of temperature, ultimately influencing behavioural thermoregulation and that the magnitude of this effect could be influenced by daily physical training. METHODS: Fourteen men were confined 10 days to a normobaric hypoxic environment (PIO2 = 88.2 ± 0...
February 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28012117/complete-genome-sequence-analysis-of-chicken-astrovirus-isolate-from-india
#19
Amrutlal K Patel, Ramesh J Pandit, Jalpa R Thakkar, Ankit T Hinsu, Vinod C Pandey, Joy K Pal, Kantilal S Prajapati, Subhash J Jakhesara, Chaitanya G Joshi
OBJECTIVE: Chicken astroviruses have been known to cause severe disease in chickens leading to increased mortality and "white chicks" condition. Here we aim to characterize the causative agent of visceral gout suspected for astrovirus infection in broiler breeder chickens. METHODS: Total RNA isolated from allantoic fluid of SPF embryo passaged with infected chicken sample was sequenced by whole genome shotgun sequencing using ion-torrent PGM platform. The sequence was analysed for the presence of coding and non-coding features, its similarity with reported isolates and epitope analysis of capsid structural protein...
March 2017: Veterinary Research Communications
https://www.readbyqxmd.com/read/27935361/acute-impairment-of-saccadic-eye-movements-is-associated-with-delayed-cerebral-ischemia-after-aneurysmal-subarachnoid-hemorrhage
#20
Matthew J Rowland, Payashi Garry, Jon Westbrook, Rufus Corkill, Chrystalina A Antoniades, Kyle T S Pattinson
OBJECTIVE Delayed cerebral ischemia (DCI) causing cerebral infarction remains a significant cause of morbidity and mortality following aneurysmal subarachnoid hemorrhage (aSAH). Early brain injury in the first 72 hours following rupture is likely to play a key role in the pathophysiology underlying DCI but remains difficult to quantify objectively. Current diagnostic modalities are based on the concept of vasoconstriction causing cerebral ischemia and infarction and are either invasive or have a steep learning curve and user variability...
October 2017: Journal of Neurosurgery
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