Haiyin Wu, Zhenquan Huang, Xuan Wang, Mingyu Chen, Wei Chen, Yao Hua, Jian Ren, Luyao Shen, Yixuan Song, Ying Zhou, Chunxia Luo, Yuhui Lin, Yilong Wang, Lei Chang, Fei Li, Dongya Zhu
BACKGROUND: Poststroke depression and anxiety, independent predictor of poor functional outcomes, are common in the acute phase of stroke. Up to now, there is no fast-onset antidepressive and anxiolytic agents suitable for the management of acute stroke. ZL006-05, a dual-target analgesic we developed, dissociates nitric oxide synthase from postsynaptic density-95 while potentiates α2-containing γ-aminobutyric acid type A receptor. This study aims to determine whether ZL006-05 can be used as an antistroke agent with fast-onset antidepressant and anxiolytic effects...
April 25, 2023: Stroke and Vascular Neurology