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Nonconvulsive status epilepticus

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https://www.readbyqxmd.com/read/29125184/hepatic-and-hippocampal-cytochrome-p450-enzyme-overexpression-during-spontaneous-recurrent-seizures
#1
Leonie Runtz, Benoit Girard, Marion Toussenot, Julie Espallergues, Alexis Fayd'Herbe De Maudave, Alexandre Milman, Frederic deBock, Chaitali Ghosh, Nathalie C Guérineau, Jean-Marc Pascussi, Federica Bertaso, Nicola Marchi
OBJECTIVE: Available evidence points to a role of cytochrome P450 (Cyp) drug biotransformation enzymes in central nervous system diseases, including epilepsy. Deviations in drug pharmacokinetic profiles may impact therapeutic outcomes. Here, we ask whether spontaneous recurrent seizure (SRS) activity is sufficient to modulate the expression of major Cyp enzymes in the liver and brain. METHODS: Unilateral intrahippocampal (IH) kainic acid (KA) injections were used to elicit nonconvulsive status epilepticus (SE), epileptogenesis, and SRS, as monitored by video-electroencephalography...
November 10, 2017: Epilepsia
https://www.readbyqxmd.com/read/29081627/looking-beyond-the-obvious-cefepime-induced-nonconvulsive-status-epilepticus
#2
Vinayaka Anuhya, Sushil Kiran Kunder, Sharath Madhyastha, Veena Nayak, Raviraja V Acharya, Kusugodlu Ramamoorthi, Avinash Arivazhahan, Rahul Sai Gangula
Cephalosporins are a commonly used class of antibiotics in various types of infections. Cefepime, a fourth-generation cephalosporin, has been reported to cause neurotoxicity, which can present itself as varied manifestations. Nonconvulsive status epilepticus (NCSE) is a rare manifestation of this neurotoxicity. This condition often proves difficult to diagnose because it is chiefly an electroencephalogram-based diagnosis. The authors report a case of cefepime-induced NCSE in a 57-year-old female patient with compromised renal status...
July 2017: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/29071284/characterizing-cefepime-neurotoxicity-a-systematic-review
#3
REVIEW
Ayesha A Appa, Rupali Jain, Robert M Rakita, Shahin Hakimian, Paul S Pottinger
Neurotoxicity due to cefepime has not been well characterized. We performed a systematic review of the literature and included 5 additional cases from our center. Of the 198 cases found, the mean age was 67 years and 87% of patients had renal dysfunction. The most common clinical features were diminished level of consciousness (80%), disorientation/agitation (47%), and myoclonus (40%). It is worth noting that nonconvulsive status epilepticus was relatively common with 31% of cases, whereas only 11% had convulsive seizures...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29064811/-the-risk-of-epileptic-seizures-during-antibiotic-therapy
#4
Ewa Czapińska-Ciepiela
Numerous antibiotics may trigger epileptic seizures or status epilepticus by decreasing inhibitory transmission in the brain, thus lowering the seizure threshold. The most potent seizurogenic effect is exerted by penicillins, cephalosporins, fluorochinolons and carbapenems. Predisposing factors that facilitate development of epileptic seizures in the course of antibiotic therapy comprise all conditions accompanied by damage to the blood-brain barrier (including cerebral trauma and encephalitis), a high dose of an antibiotic or lack of adequate dose adjustment in patients with renal failure...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29037936/super-refractory-nonconvulsive-status-epilepticus-due-to-self-poisoning-with-metaldehyde
#5
José L Fernández-Torre, Alicia Paramio-Paz, Juan Carlos Rodríguez-Borregán, Pedro Orizaola, Pilar Bosque-Varela, Miguel A Hernández-Hernández
INTRODUCTION: Metaldehyde self-poisoning in adults is uncommon and, to the best of our knowledge, an episode of super-refractory nonconvulsive status epilepticus (sr-NCSE) following an suicide attempt has not been previously demonstrated. CASE REPORT: A 68-year-old woman was admitted to our Intensive Care Unit (ICU) in coma. On neurologic examination, the pupils were reactive, brainstem reflexes were present and plantar responses were flexor bilaterally. Routine laboratory tests were unremarkable...
October 13, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28979770/novel-clinical-features-of-nonconvulsive-status-epilepticus
#6
REVIEW
Masao Nagayama, Sunghoon Yang, Romergryko G Geocadin, Peter W Kaplan, Eisei Hoshiyama, Azusa Shiromaru-Sugimoto, Mitsuru Kawamura
Nonconvulsive status epilepticus (NCSE) has rapidly expanded from classical features such as staring, repetitive blinking, chewing, swallowing, and automatism to include coma, prolonged apnea, cardiac arrest, dementia, and higher brain dysfunction, which were demonstrated mainly after the 2000s by us and other groups. This review details novel clinical features of NCSE as a manifestation of epilepsy, but one that is underdiagnosed, with the best available evidence. Also, we describe the new concept of epilepsy-related organ dysfunction (Epi-ROD) and a novel electrode and headset which enables prompt electroencephalography...
2017: F1000Research
https://www.readbyqxmd.com/read/28963903/fatty-acid-amide-hydrolase-inhibitor-urb597-may-protect-against-kainic-acid-induced-damage-to-hippocampal-neurons-dependence-on-the-degree-of-injury
#7
Irina B Mikheeva, Liubov Shubina, Nataliya Matveeva, Luybov L Pavlik, Valentina F Kitchigina
OBJECTIVE: Status epilepticus (SE) provokes changes, which lead to neuronal alterations. Endocannabinoids (eCBs) can affect the neuronal survival during excitotoxicity and brain damage. Using a kainic acid (KA)-induced experimental SE model, we investigated whether cellular changes entail damage to endoplasmic reticulum (ER), mitochondria, and nuclei in hippocampal cells (CA1 field), and whether these alterations can be diminished by treatment with URB597, an inhibitor of eCB enzymatic degradation...
September 22, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28922287/pregabalin-toxicity-manifesting-as-reversible-encephalopathy-with-continuous-triphasic-waves-in-electroencephalogram
#8
Mihir Parekh, Gopal Krishna Dash, Isthiaque Ahamed
A 74-year-old man with peripheral neuropathy due to diabetes presented with deliberate ingestion of 450 mg of pregabalin (PBG) over a period of 8 hours followed by altered mental status. A bedside electroencephalogram was performed to rule out nonconvulsive status epilepticus, which showed continuous triphasic waves (TWs) with slow background activity. He recovered after 48 hours of stopping PBG, and his repeat electroencephalogram after 72 hours did not show any TWs. We present a rare case of PBG-induced TWs thereby highlighting the extent of the etiologic spectrum of TWs and discussing the literature related to this association...
September 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28866335/predictors-of-outcomes-and-refractoriness-in-status-epilepticus-a-prospective-study
#9
Murat Mert Atmaca, Nerses Bebek, Betül Baykan, Ayşen Gökyiğit, Candan Gürses
OBJECTIVE: The objective of this study was to determine the predictors of outcomes and refractoriness in status epilepticus (SE). METHODS: This is a prospective study of 59 adult patients with SE who were admitted to the Emergency Department between February 2012 and December 2013. The effects of clinical, demographic, and electrophysiologic features of patients with SE were evaluated. To evaluate outcome in SE, STESS, mSTESS, and EMSE scales were used. RESULTS: Logistic regression analysis showed that being aged ≥65years (p=0...
August 31, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28858905/electroencephalogram-abnormalities-during-positional-changes-in-brain-sagging-syndrome
#10
Benziger Bensam, Heustein L Sy, Nadia Sotudeh, Paulomi K Bhalla, Sean T Hwang, David E LeDoux
PURPOSE: Brain sagging after craniotomy and clipping of a ruptured aneurysm is a rare complication. Clinical and electrographic changes in patients with a final diagnosis of intracranial hypotension are not well described, and can be mistaken on rare occasions for other entities such as nonconvulsive status epilepticus. There may be resulting delay in the diagnosis and treatment of this potentially life-threatening disorder. METHODS: Case report and imaging. RESULTS: We present a case of intracranial hypotension in which concerning continuous electroencephalogram (cEEG) and quantitative EEG (qEEG) findings were noted during active sagging of the brain, which resolved with supine positioning...
August 30, 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/28844159/do-video-eeg-monitoring-findings-in-icu-patients-with-acute-stroke-predict-development-of-seizures-and-survival-during-follow-up
#11
Halil Onder, Ethem Murat Arsava, Mehmet Akif Topcuoglu, Nese Dericioglu
PURPOSE: Ischemic or hemorrhagic stroke are among the most common causes of seizures, especially in the elderly. EEG is the only technique that can detect epileptiform abnormalities (EA) and nonconvulsive status epilepticus (NCSE), which may negatively affect recovery of these patients. Herein we aimed to investigate the potential predictive value of long-term EEG findings in terms of poststroke seizures (PSS) and survival, in stroke patients followed up in the neurological intensive care unit (NICU)...
November 2017: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/28808577/transition-from-intravenous-to-enteral-ketamine-for-treatment-of-nonconvulsive-status-epilepticus
#12
Michael A Pizzi, Prasuna Kamireddi, William O Tatum, Jerry J Shih, Daniel A Jackson, William D Freeman
BACKGROUND: Nonconvulsive status epilepticus (NCSE) is a diagnosis that is often challenging and one that may progress to refractory NCSE. Ketamine is a noncompetitive N-methyl-d-aspartate antagonist that increasingly has been used to treat refractory status epilepticus. Current Neurocritical Care Society guidelines recommend intravenous (IV) ketamine infusion as an alternative treatment for refractory status epilepticus in adults. On the other hand, enteral ketamine use in NCSE has been reported in only 6 cases (1 adult and 5 pediatric) in the literature to date...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/28802513/nonconvulsive-status-epilepticus-after-electroconvulsive-therapy-a-review-of-literature
#13
Awais Aftab, Ashley VanDercar, Ayham Alkhachroum, Christine LaGrotta, Keming Gao
BACKGROUND: The clinical presentation and risk factors of nonconvulsive status epilepticus (NCSE) in the context of electroconvulsive therapy (ECT) are poorly understood, and guidance regarding diagnosis and management remains scarce. In this article, we identify case reports of ECT-induced NCSE from literature, and discuss the presentation, diagnosis, and management of these cases in the context of what is known about NCSE from the neurology literature. METHODS: A literature search on PubMed for case reports of NCSE after ECT...
July 15, 2017: Psychosomatics
https://www.readbyqxmd.com/read/28682826/misleading-eeg-lateralization-associated-with-midline-shift
#14
Gena R Ghearing, Sergiu Abramovici, Alexandra Popescu, Maria E Baldwin
Midline discharges, lateralized periodic discharges, and seizures have been described with ipsilateral lesions that result in midline shift (MLS). Periodic discharges and seizures arising contralateral to a known lesion have not previously been described as a sign of MLS. We present four patients with focal brain lesions, resulting in MLS and epileptiform discharges arising from the contralateral hemisphere. Patient 1 underwent a right anterior temporal lobectomy. On postoperative day 2, computed tomography demonstrated a right to left MLS of 12 mm, and EEG was remarkable for left temporal nonconvulsive status epilepticus...
July 4, 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/28680316/electroencephalographic-patterns-recorded-by-continuous-eeg-monitoring-in-patients-with-change-of-consciousness-in-the-neurological-intensive-care-unit
#15
Ebru Altindağ, Zeynep Vildan Okudan, Sedef Tavukçu Özkan, Yakup Krespi, Betül Baykan
INTRODUCTION: Our aim was to examine the frequency of various electrographic patterns including periodic discharges (PD), repetitive spike waves (RSW), rhythmic delta activities (RDA), nonconvulsive seizures (NCS) and nonconvulsive status epilepticus (NCSE) in continuous EEG monitoring (cEEG) of the critically ill patients with change of consciousness and the presence of specific clinical and laboratory findings associated with these important patterns in this study. METHODS: Patients with changes of consciousness in the neurological intensive care unit (NICU) were consecutively monitored with cEEG during 2 years...
June 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/28659426/emergency-response-to-out-of-hospital-status-epilepticus-a-10-year-observational-cohort-study
#16
Saskia Semmlack, Désirée Yeginsoy, Rainer Spiegel, Kai Tisljar, Stephan Rüegg, Stephan Marsch, Raoul Sutter
OBJECTIVE: To determine the implications of first responses of emergency medical services (EMS) to out-of-hospital status epilepticus (SE) on outcome. METHODS: From 2005 to 2014, prehospital and in-hospital data were assessed in consecutive adults admitted to an academic medical center with out-of-hospital SE. Logistic regression was performed to identify variables with a robust association between missed epileptic events by the EMS and no recovery to functional baseline in survivors...
July 25, 2017: Neurology
https://www.readbyqxmd.com/read/28542864/circadian-clustering-of-spontaneous-epileptic-seizures-emerges-after-pilocarpine-induced-status-epilepticus
#17
Julika Pitsch, Albert J Becker, Susanne Schoch, Johannes Alexander Müller, Marco de Curtis, Vadym Gnatkovsky
OBJECTIVE: Seizures in mesial temporal lobe epilepsy (MTLE) associated with hippocampal sclerosis are thought to develop with various latency intervals after an initial transient brain insult. To study seizure dynamics after an initial transient precipitating insult in a systematic fashion, we utilized continuous video-electroencephalography (EEG) monitoring after the induction of status epilepticus (SE) in a mouse MTLE model. METHODS: Continuous 24/7 video/telemetric hippocampal EEG recordings in the systemic pilocarpine MTLE mouse model...
July 2017: Epilepsia
https://www.readbyqxmd.com/read/28460495/acute-ischemic-stroke-in-nonconvulsive-status-epilepticus-underestimated-results-from-an-eight-year-cohort-study
#18
Christopher Traenka, Gian Marco De Marchis, Lisa Hert, David J Seiffge, Alexandros Polymeris, Nils Peters, Leo H Bonati, Stefan Engelter, Philippe Lyrer, Stephan Rüegg, Raoul Sutter
No abstract text is available yet for this article.
May 2017: Journal of Stroke
https://www.readbyqxmd.com/read/28455892/psychotic-symptoms-as-a-complication-of-electroconvulsive-therapy-a-case-report
#19
Anna Antosik-Wójcińska, Magdalena Chojnacka, Łukasz Święcicki
We report a patient who experienced atypical symptoms in the course of electroconvulsive therapy (ECT). During ECT treatment patient experienced psychotic symptoms which should be differentiated with prolonged delirium and nonconvulsive status epilepticus. 46-year-old female was referred to hospital with a diagnosis of major depressive disorder with no psychotic features in the course of recurrent depression. Despite several changes of pharmacological treatment no improvement was achieved, therefore it was decided to initiate ECT...
February 26, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/28445615/status-epilepticus-in-dogs-and-cats-part-1-etiopathogenesis-epidemiology-and-diagnosis
#20
REVIEW
Susan Blades Golubovic, John H Rossmeisl
OBJECTIVE: To review current knowledge of the etiopathogenesis, diagnosis, and consequences of status epilepticus (SE) in veterinary patients. DATA SOURCES: Human and veterinary literature, including clinical and laboratory research and reviews. ETIOPATHOGENESIS: Status epilepticus is a common emergency in dogs and cats, and may be the first manifestation of a seizure disorder. It results from the failure of termination of an isolated seizure...
May 2017: Journal of Veterinary Emergency and Critical Care
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