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https://www.readbyqxmd.com/read/28944724/rapid-prototyping-of-a-cyclic-olefin-copolymer-microfluidic-device-for-automated-oocyte-culturing
#1
Miguel Berenguel-Alonso, Maria Sabés-Alsina, Roser Morató, Oriol Ymbern, Laura Rodríguez-Vázquez, Oriol Talló-Parra, Julián Alonso-Chamarro, Mar Puyol, Manel López-Béjar
Assisted reproductive technology (ART) can benefit from the features of microfluidic technologies, such as the automation of time-consuming labor-intensive procedures, the possibility to mimic in vivo environments, and the miniaturization of the required equipment. To date, most of the proposed approaches are based on polydimethylsiloxane (PDMS) as platform substrate material due to its widespread use in academia, despite certain disadvantages, such as the elevated cost of mass production. Herein, we present a rapid fabrication process for a cyclic olefin copolymer (COC) monolithic microfluidic device combining hot embossing-using a low-temperature cofired ceramic (LTCC) master-and micromilling...
October 2017: SLAS Technology
https://www.readbyqxmd.com/read/28943875/chasing-after-non-cyanobacterial-nitrogen-fixation-in-marine-pelagic-environments
#2
Pia H Moisander, Mar Benavides, Sophie Bonnet, Ilana Berman-Frank, Angelicque E White, Lasse Riemann
Traditionally, cyanobacterial activity in oceanic photic layers was considered responsible for the marine pelagic dinitrogen (N2) fixation. Other potentially N2-fixing bacteria and archaea have also been detected in the pelagic water column, however, the activity and importance of these non-cyanobacterial diazotrophs (NCDs) remain poorly constrained. In this perspective we summarize the N2 fixation rates from recently published studies on photic and aphotic layers that have been attributed to NCD activity via parallel molecular measurements, and discuss the status, challenges, and data gaps in estimating non-cyanobacterial N2 fixation NCNF in the ocean...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28943863/determination-of-geochemical-bio-signatures-in-mars-like-basaltic-environments
#3
Karen Olsson-Francis, Victoria K Pearson, Elisabeth D Steer, Susanne P Schwenzer
Bio-signatures play a central role in determining whether life existed on early Mars. Using a terrestrial basalt as a compositional analog for the martian surface, we applied a combination of experimental microbiology and thermochemical modeling techniques to identify potential geochemical bio-signatures for life on early Mars. Laboratory experiments were used to determine the short-term effects of biota on the dissolution of terrestrial basalt, and the formation of secondary alteration minerals. The chemoorganoheterotrophic bacterium, Burkholderia sp...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28941978/barriers-to-accessing-abortion-services-and-perspectives-on-using-mifepristone-and-misoprostol-at-home-in-great-britain
#4
Abigail R A Aiken, Katherine A Guthrie, Marlies Schellekens, James Trussell, Rebecca Gomperts
OBJECTIVE: To examine reasons for seeking abortion services outside the formal healthcare system in Great Britain, where abortion is legally available. STUDY DESIGN: We conducted a mixed-methods study among women resident in England, Scotland, and Wales who requested at-home medication abortion through online telemedicine initiative Women on Web (WoW) between November 22nd 2016 and March 22nd 2017. We examined the demographics and circumstances of all women requesting early medication abortion and conducted a content analysis of a sample of their anonymized emails to the service to explore their reasons for seeking help...
September 18, 2017: Contraception
https://www.readbyqxmd.com/read/28941791/methicillin-resistant-staphylococcus-aureus-mrsa-in-iran-a-systematic-review-and-meta-analysis
#5
REVIEW
Masoud Dadashi, Mohammad Javad Nasiri, Fatemeh Fallah, Parviz Owlia, Bahareh Hajikhani, Mohammad Emaneini, Mirsasan Mirpour
Methicillin-resistant Staphylococcus aureus (MRSA) remains one of the most prevalent multidrug-resistant organisms causing health care- infections. In Iran, limited data are available about how the prevalence of MRSA has changed over the past years. In the present study, we aimed to determine the exact prevalence of MRSA in different parts of Iran. Several databases including Medline, Embase, Web of sciences and Iranian databases were searched from Mar 2000 to Jan 2016 to identify studies addressing the prevalence of MRSA in Iran...
September 20, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28941727/intravenous-treatment-with-human-recombinant-apoa-i-milano-reduces-beta-amyloid-cerebral-deposition-in-the-app23-transgenic-mouse-model-of-alzheimer-s-disease
#6
Sofía Fernández-de Retana, Alex Montañola, Paula Marazuela, Maialen De La Cuesta, Aina Batlle, Marc Fatar, Saskia Grudzenski, Joan Montaner, Mar Hernández-Guillamon
Beyond the crucial role of apolipoprotein A-I (ApoA-I) on peripheral cholesterol metabolism, this apolipoprotein has also been implicated in beta amyloid (Aβ)-related neuropathologies. ApoA-I-Milano (M) is a mutated variant, which showed increased vasoprotective properties compared to ApoA-I-wild type in models of atherosclerosis and cardiovascular damage. We speculated that ApoA-I-M may also protect Aβ-affected vasculature and reverse some of the pathological features associated with Alzheimer's disease (AD)...
September 5, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28939553/should-we-abandon-finishing-the-course-of-antimicrobials
#7
EDITORIAL
Chris Del Mar, David F M Looke
No abstract text is available yet for this article.
September 22, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28939446/next-generation-terminology-infrastructure-to-support-interprofessional-care-planning
#8
Sarah Collins, Stephanie Klinkenberg-Ramirez, Kira Tsivkin, Perry L Mar, Dina Iskhakova, Hari Nandigam, Lipika Samal, Roberto A Rocha
OBJECTIVE: Develop a prototype of an interprofessional terminology and information model infrastructure that can enable care planning applications to facilitate patient-centered care, learn care plan linkages and associations, provide decision support, and enable automated, prospective analytics. DESIGN: The study steps included a 3 step approach: 1) Process model and clinical scenario development, and 2) Requirements analysis, and 3) Development and validation of information and terminology models...
September 19, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28938898/case-matched-study-of-short-term-effects-of-3d-vs-2d-laparoscopic-radical-resection-of-rectal-cancer
#9
QingMin Zeng, Fuming Lei, ZhaoYa Gao, YanZhao Wang, Qing Kun Gao
BACKGROUND: The purpose of this study is to compare and evaluate the security and efficacy of 3D vs 2D laparoscopy in rectal cancer treatment. METHODS: Forty-six patients who suffered from rectal cancer and went on laparoscopic radical resection of rectal carcinoma in Peking University Shougang Hospital from Feb. 2015 to Mar. 2016 were included in the study. They were randomly divided into two groups. The 23 patients operated with the 3D system were compared with 23 patients operated with the 2D system by perioperative data...
September 22, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28936748/quantity-and-quality-of-sweating-in-atopic-dermatitis
#10
Marlies Wruhs, Andreas Gleiß, Andreas Steiner, Paul Sator
Sweat may be an important factor in triggering an exacerbation of atopic dermatitis. It was the aim of this study to evaluate a possible correlation between atopic patients and hyperhidrosis-measured by a questionnaire-and to find out whether there are qualitative differences in sweat response-measured by sudomotor activity (sympathetic skin response test, SSR). Included were 100 study participants, of whom 50 were patients with atopic dermatitis and 50 were serving as control group. The frequency of hyperhidrosis is higher in atopic patients than in the control group (30 vs...
September 21, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28936675/reconnection-to-mechanical-ventilation-for-1%C3%A2-h-after-a-successful-spontaneous-breathing-trial-reduces-reintubation-in-critically-ill-patients-a-multicenter-randomized-controlled-trial
#11
M Mar Fernandez, Alejandro González-Castro, Monica Magret, M Teresa Bouza, Marcos Ibañez, Carolina García, Begoña Balerdi, Arantxa Mas, Vanesa Arauzo, José M Añón, Francisco Ruiz, José Ferreres, Roser Tomás, Marta Alabert, Ana Isabel Tizón, Susana Altaba, Noemi Llamas, Rafael Fernandez
BACKGROUND: Spontaneous breathing trials (SBT) can be exhausting, but the preventive role of rest has never been studied. This study aimed to evaluate whether reconnection to mechanical ventilation (MV) for 1 h after the effort of a successful SBT could reduce the need for reintubation in critically ill patients. METHODS: Randomized multicenter trial conducted in 17 Spanish medical-surgical intensive care units (Oct 2013-Jan 2015). Patients under MV for longer than 12 h who fulfilled criteria for planned extubation were randomly allocated after a successful SBT to direct extubation (control group) or reconnection to the ventilator for a 1-h rest before extubation (rest group)...
September 22, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28935849/acute-myeloid-leukemia-with-mutated-nucleophosmin-1-an-immunogenic-aml-subtype-and-potential-candidate-for-immune-checkpoint-inhibition
#12
Jochen Greiner, Susanne Hofmann, Michael Schmitt, Marlies Götz, Markus Wiesneth, Hubert Schrezenmeier, Donald Bunjes, Hartmut Döhner, Lars Bullinger
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September 21, 2017: Haematologica
https://www.readbyqxmd.com/read/28934809/ct-and-mri-techniques-for-imaging-around-orthopedic-hardware
#13
Thuy Duong Do, Reto Sutter, Stephan Skornitzke, Marc-André Weber
Orthopedic hardware impairs image quality in cross-sectional imaging. With an increasing number of orthopedic implants in an aging population, the need to mitigate metal artifacts in computed tomography and magnetic resonance imaging is becoming increasingly relevant. This review provides an overview of the major artifacts in CT and MRI and state-of-the-art solutions to improve image quality. All steps of image acquisition from device selection, scan preparations and parameters to image post-processing influence the magnitude of metal artifacts...
September 21, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28933891/the-codevelopment-of-sympathy-and-overt-aggression-from-middle-childhood-to-early-adolescence
#14
Antonio Zuffianò, Tyler Colasante, Marlis Buchmann, Tina Malti
We assessed the extent to which feelings of sympathy and aggressive behaviors codeveloped from 6 to 12 years of age in a representative sample of Swiss children (N = 1,273). Caregivers and teachers reported children's sympathy and overt aggression in 3-year intervals. Second-order latent curve models indicated general mean-level declines in sympathy and overt aggression over time, although the decline in sympathy was relatively small. Importantly, both trajectories were characterized by significant interindividual variability...
September 21, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28933529/simultaneous-production-of-anabaenopetins-and-namalides-by-the-cyanobacterium-nostoc-sp-cena543
#15
Tania K Shishido, Jouni Jokela, David P Fewer, Matti Wahlsten, Marli F Fiore, Kaarina Sivonen
Anabaenopeptins are a diverse group of cyclic peptides, which contain an unusual ureido linkage. Namalides are shorter structural homologs of anabaenopeptins, which also contain an ureido linkage. The biosynthetic origins of namalides are unknown despite a strong resemblance to anabaenopeptins. Here we show the cyanobacterium Nostoc sp. CENA543 strain producing new (nostamide B-E (2, 4, 5 and 6)) and known variants of anabaenopeptins (schizopeptin 791 (1) and anabaenopeptin 807 (3)). Surprisingly, Nostoc sp...
September 21, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28933147/antimicrobial-chitosan-and-chitosan-derivatives-a-review-of-the-structure-activity-relationship
#16
Priyanka Sahariah, Már Másson
This review gives an updated overview of the current state-of-the-art for antimicrobial chitosan and chitosan derivatives and the effects of structural modifications on activity and toxicity. The various synthetic routes introduced for chemical modification of chitosan are discussed and the most common functional groups are highlighted. Different analytical techniques used for structural characterization of the synthesized chitosan derivatives are discussed and critically evaluated. For the purpose of this review, the antimicrobial chitosan derivatives have been classified on the basis of the type of functional group conjugated to the polymer backbone...
September 21, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28932962/reduction-of-artifacts-caused-by-orthopedic-hardware-in-the-spine-in-spectral-detector-ct-examinations-using-virtual-monoenergetic-image-reconstructions-and-metal-artifact-reduction-algorithms
#17
Nils Große Hokamp, V Neuhaus, N Abdullayev, K Laukamp, S Lennartz, A Mpotsaris, J Borggrefe
OBJECTIVE: Aim of this study was to assess the artifact reduction in patients with orthopedic hardware in the spine as provided by (1) metal-artifact-reduction algorithms (O-MAR) and (2) virtual monoenergetic images (MonoE) as provided by spectral detector CT (SDCT) compared to conventional iterative reconstruction (CI). METHODS: In all, 28 consecutive patients with orthopedic hardware in the spine who underwent SDCT-examinations were included. CI, O-MAR and MonoE (40-200 keV) images were reconstructed...
September 21, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28932560/cost-and-effectiveness-of-lung-lobectomy-by-video-assisted-thoracic-surgery-for-lung-cancer
#18
Juan J Mafé, Beatriz Planelles, Santos Asensio, Jorge Cerezal, María-Del-Mar Inda, Javier Lacueva, Maria-Dolores Esteban, Luis Hernández, Concepción Martín, Benno Baschwitz, Ana M Peiró
BACKGROUND: Video-assisted thoracic surgery (VATS) emerged as a minimally invasive surgery for diseases in the field of thoracic surgery. We herein reviewed our experience on thoracoscopic lobectomy for early lung cancer and evaluated Health System use. METHODS: A cost-effectiveness study was performed comparing VATS vs. open thoracic surgery (OPEN) for lung cancer patients. Demographic data, tumor localization, dynamic pulmonary function tests [forced vital capacity (FVC), forced expiratory volume in one second (FEV1), diffusion capacity (DLCO) and maximal oxygen uptake (VO2max)], surgical approach, postoperative details, and complications were recorded and analyzed...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28932349/novel-synthetic-adhesive-as-an-effective-alternative-to-fibrin-based-adhesives
#19
Pramod Kadaba Srinivasan, Vera Sperber, Mamdouh Afify, Hirokazu Tanaka, Kenji Fukushima, Babette Kögel, Felix Gremse, René Tolba
AIM: To compare a novel, fully synthetic, polyurethane based glue (MAR-1) to fibrin sealant in a partial liver resection rat model. METHODS: After 50% resection of the lateral left liver lobe in male Wistar rats (n = 7/group/time point), MAR-1, Fibrin or NaCl was applied. After 14, 21 and 90 postoperative days, sealant degradation, intra-abdominal adhesions were scored, and histological examination of liver tissue was performed. RESULTS: (Mean ± SEM) (MAR-1 vs Fibrin vs NaCl)...
August 28, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28932200/is-increased-intracellular-calcium-in-red-blood-cells-a-common-component-in-the-molecular-mechanism-causing-anemia
#20
Laura Hertz, Rick Huisjes, Esther Llaudet-Planas, Polina Petkova-Kirova, Asya Makhro, Jens G Danielczok, Stephane Egee, Maria Del Mar Mañú-Pereira, Richard van Wijk, Joan-Lluis Vives Corrons, Anna Bogdanova, Lars Kaestner
For many hereditary disorders, although the underlying genetic mutation may be known, the molecular mechanism leading to hemolytic anemia is still unclear and needs further investigation. Previous studies revealed an increased intracellular Ca(2+) in red blood cells (RBCs) from patients with sickle cell disease, thalassemia, or Gardos channelopathy. Therefore we analyzed RBCs' Ca(2+) content from 35 patients with different types of anemia (16 patients with hereditary spherocytosis, 11 patients with hereditary xerocytosis, 5 patients with enzymopathies, and 3 patients with hemolytic anemia of unknown cause)...
2017: Frontiers in Physiology
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