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https://www.readbyqxmd.com/read/28433996/factor-xii-as-a-risk-marker-for-hemorrhagic-stroke-a-prospective-cohort-study
#1
Kristina Johansson, Jan-Håkan Jansson, Lars Johansson, Ingemar Bylesjö, Torbjörn K Nilsson, Mats Eliasson, Stefan Söderberg, Marcus Lind
BACKGROUND: Coagulation factor XII (FXII) is involved in pathological thrombus formation and is a suggested target of anticoagulants. It is unclear whether FXII levels are correlated with cardiovascular risk factors and whether they are associated with myocardial infarction or ischemic or hemorrhagic stroke. The aim of this study was to investigate the correlation between FXII and cardiovascular risk factors in the general population. We also aimed to study the associations between FXII levels and future myocardial infarction and ischemic and hemorrhagic stroke...
April 21, 2017: Cerebrovascular Diseases Extra
https://www.readbyqxmd.com/read/28431047/impact-of-the-syntax-scores-i-and-ii-in-patients-with-diabetes-and-multivessel-coronary-disease-a-pooled-analysis-of-patient-level-data-from-the-syntax-precombat-and-best-trials
#2
Rafael Cavalcante, Yohei Sotomi, Massimo Mancone, Cheol Whan Lee, Jung-Min Ahn, Yoshinobu Onuma, Pedro A Lemos, Robert-Jan van Geuns, Seung-Jung Park, Patrick W Serruys
Aims: To assess the impact of the SYNTAX scores I and II in outcomes after percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) for patients with diabetes and multivessel disease (MVD). Methods and Results: We performed a patient-level pooled analysis of three large randomized trials of patients with MVD. The impact of coronary anatomic complexity as measured by the SYNTAX score in the differences in outcomes following PCI and CABG was assessed at a median follow-up of 5 years...
April 18, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28427850/five-year-changes-in-cardiac-structure-and-function-in-patients-with-rheumatoid-arthritis-compared-with-the-general-population
#3
John M Davis, Grace Lin, Jae K Oh, Cynthia S Crowson, Sara J Achenbach, Terry M Therneau, Eric L Matteson, Richard J Rodeheffer, Sherine E Gabriel
BACKGROUND: Patients with rheumatoid arthritis (RA) have increased risk of heart failure with preserved ejection fraction. The development and progression of left ventricular dysfunction before onset of clinical heart failure are unknown. The objective of this study was to evaluate longitudinal changes in cardiac structure and function of patients with RA compared with persons in the general population. METHODS: A prospective longitudinal study of a population-based cohort of 160 patients with RA and a population-based cohort of 1391 persons without RA (non-RA cohort) was performed...
March 31, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28425767/chronic-total-coronary-occlusion-treatment-results
#4
Martin Kirk Christensen, Phillip Fischer Freeman, Jeppe Groendal Rasmussen, Anton Boel Villadsen, Bent Raungaard, Svend Eggert Jensen, Leif Thuesen
OBJECTIVES: To describe the clinical and procedural coronary chronic total occlusion (CTO) treatment results in a Nordic PCI centre during the implementation of a CTO treatment program. DESIGN: In a retrospective registry study, we assessed; (1) indication for the procedure, (2) Canadian Cardiovascular Society angina pectoris score (CCS)/New York Heart Association (NYHA) heart failure score, (3) lesion complexity and (4) adverse events during hospital stay and three months following the index procedure...
April 20, 2017: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/28419023/interrelations-of-epicardial-fat-volume-left-ventricular-t1-relaxation-times-and-myocardial-strain-in-hypertensive-patients-a-cardiac-magnetic-resonance-study
#5
Rami Homsi, Daniel Kuetting, Alois Sprinkart, Nina Steinfeld, Michael Meier-Schroers, Julian Luetkens, Jennifer Nadal, Darius Dabir, Stefan Fischer, Juergen Gieseke, Hans Schild, Daniel Thomas
PURPOSE: This cardiac magnetic resonance study was performed to assess myocardial fibrosis by evaluating T1-relaxation time (T1), to measure left ventricular (LV) strain, and to determine epicardial fat volume (EFV) in hypertensive patients with no history of cardiovascular (CV) events and to relate the results to the presence of coronary atherosclerotic artery disease (CAD) in these patients. MATERIALS AND METHODS: A total of 123 subjects were examined at 1.5 T...
May 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28415098/p569diastolic-dyssynchrony-is-associated-with-exercise-intolerance-in-hypertensive-patients-with-left-ventricular-hypertrophy
#6
I H Jung, H S Seo, M J Kim
Background: Left ventricular hypertrophy (LVH) is associated with intra-ventricular dyssynchrony at systolic phase during exercise in hypertensive patients. However, dypsnea on exertion is much more correlated with diastolic phase. We investigated whether LVH is associated with diastolic dyssynchrony during exercise in patients with hypertension. Methods: Ninety hypertensive patients with exertional dyspnea and 30 control individuals were enrolled. Exercise stress echocardiography was performed using a symptom limited, multistage supine bicycle test...
December 1, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28409231/preoperative-right-ventricular-dysfunction-is-a-strong-predictor-of-3%C3%A2-years-survival-after-cardiac-surgery
#7
Jérôme Peyrou, Christophe Chauvel, Atul Pathak, Marc Simon, Patrick Dehant, Eric Abergel
BACKGROUND: Prognostic value of right ventricular (RV) systolic function is well established in valvular disease, heart failure but has not been evaluated in patients undergoing cardiac surgery. OBJECTIVES: The aim of the present study was to evaluate the prognostic value of preoperative RV dysfunction extensively evaluated on the basis of a large set of echocardiographic parameters [S', RV fractional area change (RVFAC), right myocardial performance index (RMPI), isovolumic acceleration (IVA), RV dP/dt and basal longitudinal strain (BLS)] in a large population of unselected patient awaiting cardiac surgery...
April 13, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28408189/genetic-effects-on-the-correlation-structure-of%C3%A2-cvd-risk-factors-exome-wide-data-from-a-ghanaian-population
#8
REVIEW
Nuri Kodaman, Rafal S Sobota, Folkert W Asselbergs, Matthew T Oetjens, Jason H Moore, Nancy J Brown, Melinda C Aldrich, Scott M Williams
Plasma concentration of plasminogen activator inhibitor-1 (PAI-1) is highly correlated with several cardiovascular disease (CVD) risk factors. It also plays a direct role in CVD, including myocardial infarction and stroke, by impeding the dissolution of thrombi in the blood. Insofar as PAI-1 links CVD's risk factors to its endpoints, genetic variants modulating the relationship between PAI-1 and risk factors may be of particular clinical and biological interest. The high heritability of PAI-1, which has not been explained by genetic association studies, may also, in large part, be due to this relationship with CVD risk factors...
April 10, 2017: Global Heart
https://www.readbyqxmd.com/read/28403481/do-flow-and-pulsatility-index-within-the-accepted-ranges-predict-long-term-outcomes-after-coronary-artery-bypass-grafting
#9
Maximiliano De Leon, Roberto Stanham, Gerardo Soca, Victor Dayan
Background Transit-time flow measurement (TTFM) is the gold standard for intraoperative detection of graft failure. Several reports show that TTFM and distal coronary bed quality (DCBQ) may also be useful for midterm detection of graft failure. Nonetheless, there are no data regarding their predictive role on long-term outcomes. Methods Patients with three-vessel disease who underwent isolated coronary artery bypass grafting (CABG) in 2006 and received at least one graft to the left anterior descending artery (LAD) or to the first obtuse marginal (OM1) or posterior descending artery (PDA) were included...
April 12, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28394363/interleukin-18-mediates-cardiac-dysfunction-induced-by-western-diet-independent-of-obesity-and-hyperglycemia-in-the-mouse
#10
S Carbone, P J H Lee, A G Mauro, E Mezzaroma, R Buzzetti, B Van Tassell, A Abbate, S Toldo
Obesity and diabetes are independent risk factors for heart failure and are associated with the consumption of diet rich in saturated fat and sugar, Western diet (WD), known to induce cardiac dysfunction in the mouse through incompletely characterized inflammatory mechanisms. We hypothesized that the detrimental cardiac effects of WD are mediated by interleukin-18 (IL-18), pro-inflammatory cytokine linked to cardiac dysfunction. C57BL/6J wild-type male mice and IL-18 knockout male mice were fed high-saturated fat and high-sugar diet for 8 weeks...
April 10, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/28389968/predictors-of-left-ventricular-remodeling-after-st-elevation-myocardial-infarction
#11
Tom Hendriks, Minke H T Hartman, Pieter J J Vlaar, Niek H J Prakken, Yldau M Y van der Ende, Chris P H Lexis, Dirk J van Veldhuisen, Iwan C C van der Horst, Erik Lipsic, Robin Nijveldt, Pim van der Harst
Adverse left ventricular (LV) remodeling after acute ST-elevation myocardial infarction (STEMI) is associated with morbidity and mortality. We studied clinical, biochemical and angiographic determinants of LV end diastolic volume index (LVEDVi), end systolic volume index (LVESVi) and mass index (LVMi) as global LV remodeling parameters 4 months after STEMI, as well as end diastolic wall thickness (EDWT) and end systolic wall thickness (ESWT) of the non-infarcted myocardium, as compensatory remote LV remodeling parameters...
April 7, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28382386/effects-of-hemoglobin-level-on-myocardial-washout-rate-of-thallium-201-in-patients-with-normal-myocardial-perfusion-assessed-by-single-photon-emission-computed-tomography
#12
Satoshi Kurisu, Yoji Sumimoto, Hiroki Ikenaga, Noriaki Watanabe, Ken Ishibashi, Yoshihiro Dohi, Yukihiro Fukuda, Yasuki Kihara
Myocardial perfusion single-photon emission computed tomography (SPECT) is often performed even in patients with suspected coronary artery disease complicated by anemia. We assessed the effects of hemoglobin level on myocardial washout rate of Thallium-201 (Tl-201) in patients with normal myocardial perfusion assessed by SPECT. The study population consisted of 231 patients with summed stress score of zero on SPECT. The mean myocardial washout rate of Tl-201 in the left ventricle was calculated from the stress and the redistribution Bull's eye map...
April 5, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28381584/predicting-the-risk-of-bleeding-during-dual-antiplatelet-therapy-after-acute-coronary-syndromes
#13
Joakim Alfredsson, Benjamin Neely, Megan L Neely, Deepak L Bhatt, Shaun G Goodman, Pierluigi Tricoci, Kenneth W Mahaffey, Jan H Cornel, Harvey D White, Keith Aa Fox, Dorairaj Prabhakaran, Kenneth J Winters, Paul W Armstrong, E Magnus Ohman, Matthew T Roe
OBJECTIVES: Dual antiplatelet therapy (DAPT) with aspirin + a P2Y12 inhibitor is recommended for at least 12 months for patients with acute coronary syndrome (ACS), with shorter durations considered for patients with increased bleeding risk. However, there are no decision support tools available to predict an individual patient's bleeding risk during DAPT treatment in the post-ACS setting. METHODS: To develop a longitudinal bleeding risk prediction model, we analysed 9240 patients with unstable angina/non-ST segment elevation myocardial infarction (NSTEMI) from the Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes (TRILOGY ACS) trial, who were managed without revascularisation and treated with DAPT for a median of 14...
April 5, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28381254/effect-of-food-intake-on-myocardial-performance-index
#14
Ylva Gårdinger, Anna Dieden, Joanna Hlebowicz, Ola Björgell, Magnus Dencker
BACKGROUND: Myocardial performance index (MPI) has been investigated in a variety of populations, but the effect of food intake has not been evaluated. We assessed whether myocardial performance index is affected by food intake in healthy subjects. METHODS: Twenty-three healthy subjects aged 25.6 ± 4.5 years were investigated. MPI was measured before, 30 min after, and 110 min after a standardized meal. RESULTS: MPI decreased significantly (P < 0...
April 5, 2017: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/28380133/association-between-obstructive-sleep-apnea-and-myocardial-infarction-a-systematic-review
#15
Fernanda Porto, Yuri Saho Sakamoto, Cristina Salles
Obstructive sleep apnea (OSA) has been associated to cardiovascular risk factors. However, the association between OSA and cardiovascular disease is still controversial. The objective of the present study was to verify the association between OSA and myocardial infarction (MI). This is a systematic review of the literature performed through electronic data sources MEDLINE/PubMed, PubMed Central, Web of Science and BVS -Biblioteca Virtual em Saúde (Virtual Health Library). The descriptors used were: 'obstructive sleep apnea' AND 'polysomnography' AND 'myocardial infarction' AND 'adults NOT 'treatment...
March 30, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28378733/-prognostic-factors-in-patients-with-non-st-segment-elevation-acute-coronary-syndrome-concurrent-with-type-2-diabetes-mellitus-according-to-the-results-of-the-registry
#16
A P Golikov, S A Berns, R I Stryuk, E A Shmidt, A A Golikova, O L Barbarash
AIM: To investigate factors that influence annual prognosis in patients with non-ST-segment elevation acute coronary syndrome ((NSTEACS) concurrent with type 2 diabetes mellitus (DM2). SUBJECTS AND METHODS: The registry of patients with NSTEACS (non-ST-segment elevation myocardial infarction (NSTEMI), unstable angina) included 415 patients, of them 335 had no carbohydrate metabolic disorders, 80 had DM2. The follow-up period, during which the prognosis was evaluated in the patients, was one year after hospital discharge following the index NSTEACS event...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28377800/evaluation-of-tp-e-interval-tp-e-qt-ratio-and-tp-e-qtc-ratio-in-patients-with-subclinical-hypothyroidism
#17
Ahmet Gürdal, Hatice Eroğlu, Füsun Helvaci, Mutlu Çağan Sümerkan, Kamber Kasali, Şükrü Çetin, Gökhan Aksan, Kadriye Kiliçkesmez
BACKGROUND: Prolongation of the peak-to-end interval of the T wave (Tp-e) has been reported as associated with ventricular arrhythmias. The aim of this study was to investigate the ventricular repolarization by using the Tp-e interval, Tp-e/QT ratio and Tp-e/ QTc ratio in patients with subclinical hypothyroidism (SH). METHODS: We studied 56 volunteers: These were 28 patients with SH (mean age 45 ± 11 years) and 28 healthy subjects (mean age 34 ± 8 years). All basic biochemical parameters were analyzed and electrocardiograms (ECGs) were recorded...
March 2017: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28374415/biventricular-function-on-early-echocardiograms-in-neonatal-hypoxic-ischemic-encephalopathy
#18
Sanjeev Aggarwal, Girija Natarajan
AIM: To compare early (<24 hours) echocardiograms (ECHOs) in infants with perinatal hypoxic-ischemic encephalopathy (HIE) undergoing a)therapeutic hypothermia (TH) b) normothermia and c) normal controls. METHODS: This was a single center retrospective review of clinical early ECHOs of term infants with moderate or severe HIE and controls (with a normal ECHO <72 hours of age). Right (RVO) and left ventricular output (LVO), RV and LV myocardial performance index (MPI), systolic to diastolic duration ratio (S/D) and eccentricity indices (EI) in systole and diastole were compared using ANOVA...
April 4, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28370497/cardiac-pathophysiology-in-twin-twin-transfusion-syndrome-new-insights-into-its-evolution
#19
Christoph Wohlmuth, David Boudreaux, Kenneth J Moise, Anthony Johnson, Ramesha Papanna, Michael Bebbington, Helena M Gardiner
OBJECTIVES: In twin-twin transfusion syndrome (TTTS) unbalanced transfer of vasoactive mediators and fluid from the 'donor' to the 'recipient' alters cardiovascular function. We evaluated cardiac function in 145 monochorionic-diamniotic (MCDA) pregnancies with and without TTTS. METHODS: Echocardiography was performed in uncomplicated MCDA, n = 26; TTTS stage I+II, n = 61; TTTS stage III+IV, n = 58, before selective fetoscopic laser photocoagulation (SFLP) in TTTS, and afterwards in 41 (34%) at a mean of 1...
March 31, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28370301/evaluation-of-left-ventricular-function-in-preterm-infants-with-bronchopulmonary-dysplasia-using-various-echocardiographic-techniques
#20
Renata Bokiniec, Paweł Własienko, Maria Borszewska-Kornacka, Joanna Szymkiewicz-Dangel
AIM: Echocardiographic evaluation of left ventricular function in preterm infants with and without bronchopulmonary dysplasia. METHODS: In 82 preterm infants (32 in no-bronchopulmonary-dysplasia group, 35 in mild-bronchopulmonary-dysplasia group, and 15 in severe-bronchopulmonary-dysplasia group), echocardiography was performed on the first day of life, at 28 days of life, and at 36 weeks postconceptional age. RESULTS: The mean E/A ratio at 36 PCA was 0...
April 2017: Echocardiography
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