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https://www.readbyqxmd.com/read/28934278/intercalated-disc-in-failing-hearts-from-patients-with-dilated-cardiomyopathy-its-role-in-the-depressed-left-ventricular-function
#1
Ana Ortega, Estefanía Tarazón, Carolina Gil-Cayuela, María García-Manzanares, Luis Martínez-Dolz, Francisca Lago, José Ramón González-Juanatey, Juan Cinca, Esther Jorge, Manuel Portolés, Esther Roselló-Lletí, Miguel Rivera
Alterations in myocardial structure and reduced cardiomyocyte adhesions have been previously described in dilated cardiomyopathy (DCM). We studied the transcriptome of cell adhesion molecules in these patients and their relationships with left ventricular (LV) function decay. We also visualized the intercalated disc (ID) structure and organization. The transcriptomic profile of 23 explanted LV samples was analyzed using RNA-sequencing (13 DCM, 10 control [CNT]), focusing on cell adhesion genes. Electron microscopy analysis to visualize ID structural differences and immunohistochemistry experiments of ID proteins was also performed...
2017: PloS One
https://www.readbyqxmd.com/read/28931920/evaluation-of-circulating-levels-of-ccn2-connective-tissue-growth-factor-in-patients-with-st-elevation-myocardial-infarction
#2
Vibeke Ritschel, Christian Shetelig, Ingebjørg Seljeflot, Shanmuganathan Limalanathan, Pavel Hoffmann, Sigrun Halvorsen, Harald Arnesen, Jan Eritsland, Geir Øystein Andersen
CCN2/Connective tissue growth factor seems to be involved in development of cardiac hypertrophy and fibrosis, but a possible cardioprotective role in left ventricular (LV) remodelling following myocardial infarction has also been suggested. The main objectives of the study were therefore to investigate whether circulating CCN2 levels were associated with infarct size, LV function, adverse remodelling or clinical outcome in two cohorts of patients with ST-elevation myocardial infarction (STEMI). CCN2 was measured in 988 patients 18 hours after PCI and clinical events were recorded after 55 months in the BAMI cohort...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28931789/metabolic-syndrome-over-4-years-before-the-onset-of-cardiovascular-disease%C3%A3-nested-case-control-study
#3
Huanhuan Hu, Tohru Nakagawa, Toru Honda, Shuichiro Yamamoto, Akiko Nanri, Maki Konishi, Hiroko Okazaki, Keisuke Kuwahara, Ai Hori, Chihiro Nishiura, Ikuko Kashino, Teppei Imai, Akiko Nishihara, Shamima Akter, Toshiaki Miyamoto, Naoko Sasaki, Takayuki Ogasawara, Akihiko Uehara, Makoto Yamamoto, Taizo Murakami, Makiko Shimizu, Masafumi Eguchi, Takeshi Kochi, Satsue Nagahama, Kentaro Tomita, Isamu Kabe, Tetsuya Mizoue, Tomofumi Sone, Seitaro Dohi
BACKGROUND: We investigated the risk of cardiovascular disease (CVD) with duration of metabolic syndrome (MetS) for the past 4 years before the CVD event.Methods and Results:We performed a nested case-control study within the Japan Epidemiology Collaboration on Occupational Health Study. A total of 139 registered cases of CVD and 561 self-reported cases of CVD were identified and matched individually on age, sex, and worksite with 695 and 2,803 controls, respectively. MetS was defined by the Joint Interim Statement definition...
September 21, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28929619/assessment-of-subclinical-right-ventricular-systolic-dysfunction-in-coal-miners-using-myocardial-isovolumic-acceleration
#4
Ozge Ozcan Abacıoglu, Mehmet Kaplan, Serkan Abacıoglu, Ala Quisi
OBJECTIVE: Several studies have been conducted regarding the effects of coal mining on the respiratory system. However, there is a lack of data concerning potential effects of coal mining on the cardiovascular system. In this study, we aimed to evaluate the potential subclinical right and left ventricular dysfunction in coal miners. METHODS: This single-center, prospective study included a total of 102 patients. Patient and control groups consisted of 54 coal miners and 48 healthy men, respectively...
September 2017: Echocardiography
https://www.readbyqxmd.com/read/28916672/effects-of-statin-intensity-and-adherence-on-the-long-term-prognosis-after-acute-ischemic-stroke
#5
Jinkwon Kim, Hye Sun Lee, Chung Mo Nam, Ji Hoe Heo
BACKGROUND AND PURPOSE: Statin is an established treatment for secondary prevention after ischemic stroke. However, the effects of statin intensity and adherence on the long-term prognosis after acute stroke are not well known. METHODS: This retrospective cohort study using a nationwide health insurance claim data in South Korea included patients admitted with acute ischemic stroke between 2002 and 2012. Statin adherence and intensity were determined from the prescription data for a period of 1 year after the index stroke...
September 15, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28913629/atherogenic-index-of-plasma-is-positively-associated-with-the-risk-of-all-cause-death-in-elderly-women-a%C3%A2-10-year-follow-up
#6
Matej Bendzala, Peter Sabaka, Martin Caprnda, Andrea Komornikova, Maria Bisahova, Ruth Baneszova, Daniel Petrovic, Robert Prosecky, Luis Rodrigo, Peter Kruzliak, Andrej Dukat
BACKGROUND: The blood concentrations of total cholesterol and low-density lipoprotein (LDL) do not predict survival in patients older than 60 years. The atherogenic index of plasma (AIP) is a logarithm of the triacylglycerol to high-density lipoprotein (HDL) ratio and a surrogate for the concentration of small dense LDL. It might be a better reflection of the risk of all-cause death in elderly patients. METHODS: We conducted a prospective observational study of patients with arterial hypertension older than 60 years...
September 14, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28912359/left-ventricular-strain-rate-is-reduced-during-voluntary-apnea-in-healthy-humans
#7
Joshua R Smith, Shelbi L Sutterfield, Dryden R Baumfalk, Kaylin D Didier, Shane M Hammer, Jacob Troy Caldwell, Carl J Ade
During an apneic event, sympathetic nerve activity increases resulting in subsequent increases in left ventricular afterload and myocardial work. It is unknown how cardiac mechanics are acutely impacted by the increased myocardial work during an apneic event. 10 healthy individuals (23 ± 3 yrs) performed multiple voluntary end-expiratory apnea (VEEA) maneuvers exposed to room air, while a subset (n=7) completed multiple VEEA exposed to hyperoxic air (100% FiO2). Beat-by-beat blood pressure, heart rate and stroke volume were measured continuously...
September 14, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28899642/evaluation-of-myocardial-function-according-to-early-diastolic-intraventricular-pressure-difference-in-fetuses
#8
Yuka Yamamoto, Ken Takahashi, Yo Takemoto, Maki Kobayashi, Keiichi Itatani, Toshiaki Shimizu, Atsuo Itakura, Satoru Takeda
BACKGROUND: Intraventricular pressure difference (IVPD), the diastolic suction during early diastole, is known as a useful marker of myocardial diastolic function in adults with different heart diseases, but there are no studies of fetal IVPD. The aim of this study was to determine whether IVPD exists and changes prenatally and whether IVPD correlates with preexisting parameters to evaluate fetal cardiac diastolic function and ventricular dominance. METHODS: Cross-sectional study data (stroke volume, fetal cardiac output, E/A ratio, and myocardial performance index) from 117 healthy fetuses at 17 to 36 weeks of gestation were retrospectively evaluated...
September 9, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28895173/cardiac-changes-in-moderately-malnourished-children-and-their-correlations-with-anthropometric-and-electrolyte-changes
#9
Osama El Razaky, Ahmed Naeem, Amr Donia, Doaa El Amrousy, Noha Elfeky
OBJECTIVE: To evaluate electrocardiographic and echocardiographic changes in moderately malnourished children and to correlate them with both anthropometric and electrolyte changes. PATIENTS AND METHOD: Sixty moderately malnourished children were taken as patient group, and 60 healthy children of matched age and sex were taken as control group. Weight, height, body mass index (BMI), serum albumin, and electrolytes were measured for all children. Electrocardiographic evaluation for calculated QT (QTc) and QT dispersion (QTd) was performed...
September 12, 2017: Echocardiography
https://www.readbyqxmd.com/read/28893266/myocardial-performance-index-in-female-athletes
#10
Zahraa Alsafi, Andreas Malmgren, Petri Gudmundsson, Martin Stagmo, Magnus Dencker
BACKGROUND: Long-term intensive training leads to morphological and mechanical changes in the heart generally known as "athlete's heart". Previous studies have suggested that the diastolic and systolic function of the ventricles is unaltered in athletes compared to sedentary. The purpose of this study was to investigate myocardial performance index (MPI) by pulsed wave Doppler (PWD) and by tissue Doppler imaging (TDI) in female elite athletes compared to sedentary controls. METHODS: The study consisted of 32 athletes (mean age 20 ± 2 years) and 34 sedentary controls (mean age 23 ± 2 years)...
September 11, 2017: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/28891228/investigating-a-biomarker-driven-approach-to-target-collagen-turnover-in-diabetic-heart-failure-with-preserved-ejection-fraction-patients-effect-of-torasemide-vs-furosemide-on-serum-c-terminal-propeptide-of-procollagen-type-i-drop-pip-trial
#11
Tobias Daniel Trippel, Sophie Van Linthout, Dirk Westermann, Ruhdja Lindhorst, Anja Sandek, Stefanie Ernst, Anna Bobenko, Mario Kasner, Frank Spillmann, Arantxa González, Begoña López, Susana Ravassa, Burkert Pieske, Walter J Paulus, Javier Díez, Frank Edelmann, Carsten Tschöpe
AIM: Heart failure with preserved ejection fraction (HFpEF) is associated with myocardial remodelling including severe pro-fibrotic changes contributing to an increase in left ventricular stiffness and diastolic dysfunction. Serum C-terminal propeptide of procollagen type I (PIP) strongly correlates with the turnover of extracellular cardiac matrix proteins and fibrosis. Torasemide, but not furosemide, was described to reduce collagen type I synthesis in clinically unstable patients with heart failure with reduced ejection fraction...
September 11, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28891162/integrating-invasive-hemodynamic-parameters-into-risk-stratification-of-acute-myocardial-infarction-and-cardiogenic-shock
#12
EDITORIAL
Gennaro Giustino, George D Dangas
A ratio of systolic blood pressure over left ventricle end-diastolic pressure (SBP/LVEDP) ≤4 identifies patients with ST-elevation myocardial infarction (STEMI) at greater risk of in-hospital mortality or that may require the use of mechanical circulatory support (MCS). The predictive performance of the SBP/LVEDP ratio was comparable to non-invasive hemodynamic parameters (the shock index and the modified shock index) and established clinical risk stratification tools (the TIMI risk score). Alongside established clinical risk factors, invasive hemodynamic parameters may help in identifying STEMI patients who may benefit from early MCS...
September 1, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28890913/markers-of-cardiovascular-dysfunction-in-adolescents-with-anorexia-nervosa
#13
Reshmi Morris, Aparna Prasad, Joseph Asaro, Marla Guzman, Leslie Sanders, Amanda Hauck, Gautam K Singh, Philip T Levy
Background. Cardiovascular complications contribute to the high morbidity and mortality rate among children with anorexia nervosa (AN). Advances in cardiac imaging permit a more comprehensive assessment of myocardial performance in children that could not be previously obtained with conventional imaging. Myocardial strain analysis is an emerging quantitative echocardiographic technique to characterize global and regional ventricular function in children. Objective. To assess global and regional left ventricular (LV0 function in children newly diagnosed with AN with conventional and quantitative 2-dimensional speckle tracking echocardiographic (2DSTE)-derived strain imaging...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/28885350/usefulness-of-three-dimensional-spherical-index-to-assess-different-types-of-left-ventricular-remodeling-a-meta-analysis
#14
Decai Zeng, Hui Chen, Chun Lan Jiang, Ji Wu
BACKGROUND: Left ventricular (LV) remodeling after myocardial injury, volume or pressure overload is characterized by a change in LV shape from an ellipse to more of a sphere. The usefulness of 3-dimensional (3D) sphericity index (SpI) for accurate evaluation of LV remodeling remains uncertain despite extensive research. METHODS: We searched Pubmed, Embase, Web of Science, and Cochrane databases to identify relevant studies from January 1, 1990 to August 1, 2016...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28883853/cardiac-surgery-related-cardio-renal-syndrome-assessed-by-conventional-and-novel-biomarkers-under-or-overestimated-diagnosis
#15
Jowita Biernawska, Joanna Bober, Katarzyna Kotfis, Anna Bogacka, Edyta Barnik, Maciej Żukowski
INTRODUCTION: Serum creatinine is a 'gold standard' criterion of recognizing and staging of acute kidney injury (AKI) despite it being a suboptimal, delayed indicator. The interpretation of increased values of biomarkers imposes great difficulty regarding cardiac surgery procedures performed with cardiopulmonary bypass and may lead to under- or overestimated diagnosis. The aim of this study was to evaluate the clinical utility of the sole serum creatinine or urine neutrophil gelatinase-associated lipocalin (NGAL) concentration used for identification of patients with AKI after cardiac surgery...
August 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28878848/quantification-of-contraction-synchronicity-and-contraction-work-in-coronary-artery-disease
#16
Takanaga Niimi, Mamoru Nanasato, Hisatoshi Maeda
PURPOSE: This study quantified the contraction synchronicity (CS; with 100% representing full synchrony and -100% dyssynchrony) and contraction work (CW, millijoules per centimeter squared; representing myocardial area) in patients with reduced left ventricular ejection fraction (LVEF) associated with coronary artery disease (CAD). METHODS: CS, CW and LVEF in 104 subjects (54 CAD patients and 50 control subjects without CAD) were measured using rest electrocardiography-gated single-photon emission computed tomography (ECG SPECT)...
September 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28878683/association-between-diastolic-dysfunction-with-inflammation-and-oxidative-stress-in-females-ob-ob-mice
#17
Michelle Sartori, Filipe F Conti, Danielle da Silva Dias, Fernando Dos Santos, Jacqueline F Machi, Zaira Palomino, Dulce E Casarini, Bruno Rodrigues, Kátia De Angelis, Maria-Claudia Irigoyen
Objective: To evaluate autonomic and cardiovascular function, as well as inflammatory and oxidative stress markers in ob/ob female mice. Methods: Metabolic parameters, cardiac function, arterial pressure (AP), autonomic, hormonal, inflammatory, and oxidative stress markers were evaluated in 12-weeks female wild-type (WT group) and ob/ob mice (OB group). Results: OB animals showed increased body weight, blood glucose, and triglyceride levels, along with glucose intolerance, when compared to WT animals. Ejection fraction (EF) and AP were similar between groups; however, the OB group presented diastolic dysfunction, as well as an impairment on myocardial performance index...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28877886/pulmonary-right-ventricular-resynchronization-in-congenital-heart-disease-acute-improvement-in-right-ventricular-mechanics-and-contraction-efficiency
#18
Jan Janoušek, Jan Kovanda, Miroslav Ložek, Viktor Tomek, Pavel Vojtovič, Roman Gebauer, Peter Kubuš, Miroslav Krejčíř, Joost Lumens, Tammo Delhaas, Frits Prinzen
BACKGROUND: Electromechanical discoordination may contribute to long-term pulmonary right ventricular (RV) dysfunction in patients after surgery for congenital heart disease. We sought to evaluate changes in RV function after temporary RV cardiac resynchronization therapy. METHODS AND RESULTS: Twenty-five patients aged median 12.0 years after repair of tetralogy of Fallot and similar lesions were studied echocardiographically (n=23) and by cardiac catheterization (n=5) after primary repair (n=4) or after surgical RV revalvulation for significant pulmonary regurgitation (n=21)...
September 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28867322/recurrent-bleeding-after-perimesencephalic-hemorrhage
#19
Frans Kauw, Birgitta K Velthuis, Ufuk Kizilates, Irene C van der Schaaf, Gabriel J E Rinkel, Mervyn D I Vergouwen
BACKGROUND: Perimesencephalic hemorrhage (PMH) is a type of subarachnoid hemorrhage with excellent long-term outcomes. Only one well-documented case of in-hospital rebleeding after PMH is described in the literature, which occurred after initiating antithrombotic treatment because of myocardial ischemia. In this case report we describe a patient with PMH without antithrombotic treatment who had two episodes of recurrent bleeding on the day of ictus. In order to validate the radiological findings we conducted a case-control study...
August 31, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28866441/cardiac-magnetic-resonance-evaluation-of-left-ventricular-myocardial-strain-in-pulmonary-hypertension
#20
Kimberly Kallianos, Gabriel C Brooks, Kanae Mukai, Florent Seguro de Carvalho, Jing Liu, David M Naeger, Teresa De Marco, Karen G Ordovas
RATIONALE AND OBJECTIVES: We investigated the feasibility of detecting left ventricular (LV) cardiac magnetic resonance (CMR) strain abnormalities using feature-tracking in patients with pulmonary hypertension (PH). MATERIALS AND METHODS: CMR was performed in 16 patients with all groups of PH and in 13 controls. Global and regional peak circumferential strains (%) (which have been shown to be robust by CMR), peak diastolic strain rate (%/s), and dyssynchrony index (ms) were quantified with feature-tracking software...
August 30, 2017: Academic Radiology
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