keyword
https://read.qxmd.com/read/36385105/cbp-hsf2-structural-and-functional-interplay-in-rubinstein-taybi-neurodevelopmental-disorder
#21
JOURNAL ARTICLE
Aurélie de Thonel, Johanna K Ahlskog, Kevin Daupin, Véronique Dubreuil, Jérémy Berthelet, Carole Chaput, Geoffrey Pires, Camille Leonetti, Ryma Abane, Lluís Cordón Barris, Isabelle Leray, Anna L Aalto, Sarah Naceri, Marine Cordonnier, Carène Benasolo, Matthieu Sanial, Agathe Duchateau, Anniina Vihervaara, Mikael C Puustinen, Federico Miozzo, Patricia Fergelot, Élise Lebigot, Alain Verloes, Pierre Gressens, Didier Lacombe, Jessica Gobbo, Carmen Garrido, Sandy D Westerheide, Laurent David, Michel Petitjean, Olivier Taboureau, Fernando Rodrigues-Lima, Sandrine Passemard, Délara Sabéran-Djoneidi, Laurent Nguyen, Madeline Lancaster, Lea Sistonen, Valérie Mezger
Patients carrying autosomal dominant mutations in the histone/lysine acetyl transferases CBP or EP300 develop a neurodevelopmental disorder: Rubinstein-Taybi syndrome (RSTS). The biological pathways underlying these neurodevelopmental defects remain elusive. Here, we unravel the contribution of a stress-responsive pathway to RSTS. We characterize the structural and functional interaction between CBP/EP300 and heat-shock factor 2 (HSF2), a tuner of brain cortical development and major player in prenatal stress responses in the neocortex: CBP/EP300 acetylates HSF2, leading to the stabilization of the HSF2 protein...
November 16, 2022: Nature Communications
https://read.qxmd.com/read/36347262/sexually-transmitted-infection-testing-among-transgender-and-non-binary-persons-results-of-a-community-based-cross-sectional-survey
#22
JOURNAL ARTICLE
Ashley Lacombe-Duncan, Shanna K Kattari, Leonardo Kattari, Ayden I Scheim, Brayden A Misiolek
BACKGROUND: Studies show higher rates of sexually transmitted infections (STIs) among transgender (trans) and non-binary (TNB) persons compared with the general population. Scant studies have examined non-HIV STI testing (henceforth referred to as STI testing); fewer inclusive of trans men and non-binary persons. We characterised the prevalence of STI testing and time since last STI test and gender-based differences in these outcomes among TNB persons. METHODS: Data were analysed from a 2018 community-based participatory cross-sectional survey (n=528)...
November 9, 2022: Sexual Health
https://read.qxmd.com/read/36244309/equine-insulin-dysregulation-causes-tissue-specific-alterations-of-proinflammatory-cytokines-and-acute-phase-proteins-in-a-nf-kb-independent-manner
#23
JOURNAL ARTICLE
W M N K Jayathilake, Martin Furr, Carlos Risco, Véronique A Lacombe
Similar to human diabetes, equine metabolic syndrome (EMS) causes insulin dysregulation leading to debilitating sequela including laminitis. The pathophysiological mechanisms underlying EMS and laminitis are not well known. Therefore, using an insulin-resistant equine model, we hypothesized that insulin dysregulation induces an increased expression of inflammatory proteins in a tissue specific manner. Two groups of horses (n = -5/group) were categorized as insulin-resistant (IR) or insulin-sensitive (IS), using a frequently sampled intra-venous glucose tolerance test...
October 8, 2022: Veterinary Immunology and Immunopathology
https://read.qxmd.com/read/36225152/hiv-testing-among-transgender-and-nonbinary-persons-in-michigan-united-states-results-of-a-community-based-survey
#24
JOURNAL ARTICLE
Ashley Lacombe-Duncan, Leonardo Kattari, Shanna K Kattari, Ayden I Scheim, Flyn Alexander, Sophie Yonce, Brayden A Misiolek
INTRODUCTION: Transgender (trans) and nonbinary people (TNB) are disproportionately impacted by HIV. HIV testing is critical to engage TNB people in HIV prevention and care. Yet, scant literature has examined social and structural factors associated with HIV testing among TNB people of diverse genders and in geographies with potentially lower trans acceptance. We: (1) characterized the prevalence of never having been tested for HIV; and (2) identified associated factors, among TNB people in Michigan, United States...
October 2022: Journal of the International AIDS Society
https://read.qxmd.com/read/35977756/nivolumab-plus-rucaparib-for-metastatic-castration-resistant-prostate-cancer-results-from-the-phase-2-checkmate-9kd-trial
#25
JOURNAL ARTICLE
Karim Fizazi, Margitta Retz, Daniel P Petrylak, Jeffrey C Goh, Jose Perez-Gracia, Louis Lacombe, Stefanie Zschäbitz, Mauricio Burotto, Hakim Mahammedi, Gwenaelle Gravis, Diogo Assed Bastos, Steven L McCune, Juan Carlos Vázquez Limón, Edmond M Kwan, Daniel Castellano, Aude Fléchon, Fred Saad, Marc-Oliver Grimm, David R Shaffer, Andrew J Armstrong, Prabhu Bhagavatheeswaran, Neha P Amin, Keziban Ünsal-Kaçmaz, Xuya Wang, Jun Li, Andrea Loehr, Russell K Pachynski
BACKGROUND: CheckMate 9KD (NCT03338790) is a non-randomized, multicohort, phase 2 trial of nivolumab plus other anticancer treatments for metastatic castration-resistant prostate cancer (mCRPC). We report results from cohorts A1 and A2 of CheckMate 9KD, specifically evaluating nivolumab plus rucaparib. METHODS: CheckMate 9KD enrolled adult patients with histologically confirmed mCRPC, ongoing androgen deprivation therapy, and an Eastern Cooperative Oncology Group performance status of 0-1...
August 2022: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/35954173/uridine-diphosphate-glucuronosyl-transferase-2b28-ugt2b28-promotes-tumor-progression-and-is-elevated-in-african-american-prostate-cancer-patients
#26
JOURNAL ARTICLE
Anindita Ravindran, Kimiko L Krieger, Akash K Kaushik, Hélène Hovington, Sadia Mehdi, Danthasinghe Waduge Badrajee Piyarathna, Vasanta Putluri, Paul Basil, Uttam Rasaily, Franklin Gu, Truong Dang, Jong Min Choi, Rajni Sonavane, Sung Yun Jung, Lisha Wang, Rohit Mehra, Nancy L Weigel, Nagireddy Putluri, David R Rowley, Ganesh S Palapattu, Chantal Guillemette, Louis Lacombe, Éric Lévesque, Arun Sreekumar
Prostate cancer (PCa) is the second most diagnosed cancer in the United States and is associated with metabolic reprogramming and significant disparities in clinical outcomes among African American (AA) men. While the cause is likely multi-factorial, the precise reasons for this are unknown. Here, we identified a higher expression of the metabolic enzyme UGT2B28 in localized PCa and metastatic disease compared to benign adjacent tissue, in AA PCa compared to benign adjacent tissue, and in AA PCa compared to European American (EA) PCa...
July 29, 2022: Cells
https://read.qxmd.com/read/35086626/why-are-people-still-dying-of-drug-susceptible-tb-in-paris-in-the-21-st-century
#27
JOURNAL ARTICLE
A-L Beaumont, A Doumbia, N Château, J-L Meynard, J Pacanowski, N Valin, J Cadranel, V Lalande, C Verdet, L Lassel, G Pialoux, O Fain, M Morgand, K Lacombe, L Surgers
BACKGROUND: Although the burden of TB is lower in France than in low-income countries, patients continue to die from TB in Paris. Our goal was to describe TB-related deaths and to identify associated risk factors. METHODS: We conducted a retrospective cohort study in two hospitals in Paris between 2013 and 2018. All patients with drug-susceptible TB were included and followed until end of treatment. The primary outcome was death. We performed univariate and multivariate analysis using Cox proportional hazard model...
February 1, 2022: International Journal of Tuberculosis and Lung Disease
https://read.qxmd.com/read/34945053/spectral-photon-counting-ct-technology-in-chest-imaging
#28
REVIEW
Salim Aymeric Si-Mohamed, Jade Miailhes, Pierre-Antoine Rodesch, Sara Boccalini, Hugo Lacombe, Valérie Leitman, Vincent Cottin, Loic Boussel, Philippe Douek
The X-ray imaging field is currently undergoing a period of rapid technological innovation in diagnostic imaging equipment. An important recent development is the advent of new X-ray detectors, i.e., photon-counting detectors (PCD), which have been introduced in recent clinical prototype systems, called PCD computed tomography (PCD-CT) or photon-counting CT (PCCT) or spectral photon-counting CT (SPCCT) systems. PCD allows a pixel up to 200 microns pixels at iso-center, which is much smaller than that can be obtained with conventional energy integrating detectors (EID)...
December 9, 2021: Journal of Clinical Medicine
https://read.qxmd.com/read/34724563/2021-update-on-mrd-in-acute-myeloid-leukemia-a-consensus-document-from-the-european-leukemianet-mrd-working-party
#29
JOURNAL ARTICLE
Michael Heuser, Sylvie D Freeman, Gert J Ossenkoppele, Francesco Buccisano, Christopher S Hourigan, Lok Lam Ngai, Jesse M Tettero, Costa Bachas, Constance Baer, Marie-Christine Béné, Veit Bücklein, Anna Czyz, Barbara Denys, Richard Dillon, Michaela Feuring-Buske, Monica L Guzman, Torsten Haferlach, Lina Han, Julia K Herzig, Jeffrey L Jorgensen, Wolfgang Kern, Marina Y Konopleva, Francis Lacombe, Marta Libura, Agata Majchrzak, Luca Maurillo, Yishai Ofran, Jan Philippe, Adriana Plesa, Claude Preudhomme, Farhad Ravandi, Christophe Roumier, Marion Subklewe, Felicitas Thol, Arjan A van de Loosdrecht, Bert A van der Reijden, Adriano Venditti, Agnieszka Wierzbowska, Peter J M Valk, Brent L Wood, Roland B Walter, Christian Thiede, Konstanze Döhner, Gail J Roboz, Jacqueline Cloos
Measurable residual disease (MRD) is an important biomarker in acute myeloid leukemia (AML) that is used for prognostic, predictive, monitoring, and efficacy-response assessments. The European LeukemiaNet (ELN) MRD Working Party evaluated standardization and harmonization of MRD in an ongoing manner and has updated the 2018 ELN MRD recommendations based on significant developments in the field. New and revised recommendations were established during in-person and online meetings, and a 2-stage Delphi poll was conducted to optimize consensus...
December 30, 2021: Blood
https://read.qxmd.com/read/34690281/the-hepatitis-c-cascade-of-care-in-hiv-hepatitis-c-virus-coinfected-individuals-in-europe-regional-and-intra-regional-differences
#30
JOURNAL ARTICLE
Olga Fursa, Amanda Mocroft, Jeffrey V Lazarus, Sarah Amele, Jens Lundgren, Raimonda Matulionyte, Line D Rasmussen, Jürgen K Rockstroh, Milosz Parczewski, David Jilich, Santiago Moreno, Anna Vassilenko, Karine Lacombe, Gilles Wandeler, Elena Borodulina, Johanna Brännström, Lothar Wiese, Chloe Orkin, Georg M N Behrens, Kamal Mansinho, Jose Joaquin Portu, Lars Peters
BACKGROUND: Following the introduction of direct-acting antiviral therapy in 2013, WHO launched the first Global Health Sector Strategy on Viral Hepatitis. We describe a hepatitis C virus (HCV) cascade of care in people with HIV (PWH) across Europe in terms of reaching the WHO elimination targets of diagnosing 90% and treating 80% of HCV-infected individuals. METHODS: HIV/HCV-coinfected participants in the EuroSIDA cohort under prospective follow-up at October 1, 2019, were described using a nine-stage cascade of care...
March 1, 2022: AIDS
https://read.qxmd.com/read/34656860/the-arabidopsis-protein-npf6-2-nrt1-4-is-a-plasma-membrane-nitrate-transporter-and-a-target-of-protein-kinase-cipk23
#31
JOURNAL ARTICLE
Laura Morales de Los Ríos, Claire Corratgé-Faillie, Natalia Raddatz, Imelda Mendoza, Marika Lindahl, Alexis de Angeli, Benoit Lacombe, Francisco J Quintero, José M Pardo
Nitrate and potassium nutrition is tightly coordinated in vascular plants. Physiological and molecular genetics studies have demonstrated that several NPF/NRT1 nitrate transporters have a significant impact on both uptake and the root-shoot partition of these nutrients. However, how these traits are biochemically connected remain controversial since some NPF proteins, e.g. NPF7.3/NRT1.5, have been suggested to mediate K+ /H+ exchange instead of nitrate fluxes. Here we show that NPF6.2/NRT1.4, a protein that gates nitrate accumulation at the leaf petiole of Arabidopsis thaliana, also affects the root/shoot distribution of potassium...
October 11, 2021: Plant Physiology and Biochemistry: PPB
https://read.qxmd.com/read/34488870/the-pan-ppar-agonist-lanifibranor-reduces-development-of-lung-fibrosis-and-attenuates-cardiorespiratory-manifestations-in-a-transgenic-mouse-model-of-systemic-sclerosis
#32
JOURNAL ARTICLE
Emma Derrett-Smith, Kristina E N Clark, Xu Shiwen, David J Abraham, Rachel K Hoyles, Olivier Lacombe, Pierre Broqua, Jean Louis Junien, Irena Konstantinova, Voon H Ong, Christopher P Denton
BACKGROUND: The TβRII∆k-fib transgenic (TG) mouse model of scleroderma replicates key fibrotic and vasculopathic complications of systemic sclerosis through fibroblast-directed upregulation of TGFβ signalling. We have examined peroxisome proliferator-activated receptor (PPAR) pathway perturbation in this model and explored the impact of the pan-PPAR agonist lanifibranor on the cardiorespiratory phenotype. METHODS: PPAR pathway gene and protein expression differences from TG and WT sex-matched littermate mice were determined at baseline and following administration of one of two doses of lanifibranor (30 mg/kg or 100 mg/kg) or vehicle administered by daily oral gavage up to 4 weeks...
September 6, 2021: Arthritis Research & Therapy
https://read.qxmd.com/read/34453843/potency-ranking-of-per-and-polyfluoroalkyl-substances-using-high-throughput-transcriptomic-analysis-of-human-liver-spheroids
#33
JOURNAL ARTICLE
A J F Reardon, A Rowan-Carroll, S S Ferguson, K Leingartner, R Gagne, B Kuo, A Williams, L Lorusso, J A Bourdon-Lacombe, R Carrier, I Moffat, C L Yauk, E Atlas
Per- and polyfluoroalkyl substances (PFAS) are some of the most prominent organic contaminants in human blood. Although the toxicological implications of human exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) are well established, data on lesser-understood PFAS are limited. New approach methodologies (NAMs) that apply bioinformatic tools to high-throughput data are being increasingly considered to inform risk assessment for data-poor chemicals. The aim of this study was to compare the potencies (i...
August 28, 2021: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/34198000/tocilizumab-and-covid-19-timing-of-administration-assessment
#34
JOURNAL ARTICLE
Q Richier, V Jachiet, V Bonnemains, L Plaçais, N Abisror, M Garnier, J Pacanowski, R Dhote, O Hinchschberger, M Michel, B Bienvenu, C Comarmond, K Lacombe, A Mekinian
Recent evidence showed greater efficacy of tocilizumab (TCZ) in the subgroups of COVID-19 patients who presented with symptoms for less than 7 days and in those only receiving oxygen. We retrospectively analyzed a compassionate use cohort to determine the best timing for TCZ injection. We showed no association between the timing of injection after symptom onset and the efficacy of TCZ on mortality. We then investigated whether the oxygen level at the time of TCZ injection impacted the mortality rate. Our study finally suggested that TCZ could be less effective when oxygen requirement is >11 L/min and we hypothesized that earlier administration could be associated with better outcome...
June 28, 2021: Infectious diseases now
https://read.qxmd.com/read/33828339/molecular-simulations-and-mechanistic-analysis-of-the-effect-of-co-2-sorption-on-thermodynamics-structure-and-local-dynamics-of-molten-atactic-polystyrene
#35
JOURNAL ARTICLE
Eleonora Ricci, Niki Vergadou, Georgios G Vogiatzis, Maria Grazia De Angelis, Doros N Theodorou
A simulation strategy encompassing different scales was applied to the systematic study of the effects of CO2 uptake on the properties of atactic polystyrene (aPS) melts. The analysis accounted for the influence of temperature between 450 and 550 K, polymer molecular weights ( M w ) between 2100 and 31000 g/mol, and CO2 pressures up to 20 MPa on the volumetric, swelling, structural, and dynamic properties of the polymer as well as on the CO2 solubility and diffusivity by performing molecular dynamics (MD) simulations of the system in a fully atomistic representation...
May 26, 2020: Macromolecules
https://read.qxmd.com/read/33772556/high-throughput-transcriptomic-analysis-of-human-primary-hepatocyte-spheroids-exposed-to-per-and-polyfluoroalkyl-substances-pfas-as-a-platform-for-relative-potency-characterization
#36
JOURNAL ARTICLE
A Rowan-Carroll, A Reardon, K Leingartner, R Gagné, A Williams, M J Meier, B Kuo, J Bourdon-Lacombe, I Moffat, R Carrier, A Nong, L Lorusso, S S Ferguson, E Atlas, C Yauk
Per- and poly-fluoroalkyl substances (PFAS) are widely found in the environment because of their extensive use and persistence. Although several PFAS are well studied, most lack toxicity data to inform human health hazard and risk assessment. This study focussed on four model PFAS: perfluorooctanoic acid (PFOA; 8 carbon), perfluorobutane sulfonate (PFBS; 4 carbon), perfluorooctane sulfonate (PFOS; 8 carbon), and perfluorodecane sulfonate (PFDS; 10 carbon). Human primary liver cell spheroids (pooled from 10 donors) were exposed to 10 concentrations of each PFAS and analyzed at four time-points...
March 27, 2021: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/33674879/analytic-sensitivity-of-3-nucleic-acid-detection-assays-in-diagnosis-of-sars-cov-2-infection
#37
JOURNAL ARTICLE
Jakob T Sieker, Coby Horowitz, Cheng-Tsung K Hu, Meriane Lacombe-Daphnis, Bernadette Chirokas, Coteia Pina, Nicholas E Heger, Arthur R Rabson, Ming Zhou, Steven A Bogen, Gary L Horowitz
BACKGROUND: Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by reverse transcription PCR is the primary method to diagnose coronavirus disease 2019 (COVID-19). However, the analytic sensitivity required is not well defined and it is unclear how available assays compare. METHODS: For the Abbott RealTime SARS-CoV-2 assay (m2000; Abbott Molecular), we determined that it could detect viral concentrations as low as 26 copies/mL, we defined the relationship between cycle number and viral concentrations, and we tested naso- and oropharyngeal swab specimens from 8538 consecutive individuals...
March 1, 2021: Journal of Applied Laboratory Medicine
https://read.qxmd.com/read/33409325/influence-of-hepatitis-c-coinfection-and-treatment-on-risk-of-diabetes-mellitus-in-hiv-positive-persons
#38
JOURNAL ARTICLE
Amanda Mocroft, Jens D Lundgren, Juergen K Rockstroh, Inka Aho, Gilles Wandeler, Lars Nielsen, Simon Edwards, Jean-Paul Viard, Karine Lacombe, Gerd Fätkenheuer, Giovanni Guaraldi, Montserrat Laguno, Josep Llibre, Hila Elinav, Leo Flamholc, Martin Gisinger, Dzmitry Paduta, Irina Khromova, David Jilich, Blazej Rozplochowski, Cristiana Oprea, Lars Peters
Background: The role of hepatitis C virus (HCV) coinfection and HCV-RNA in the development of diabetes mellitus (DM) in HIV-positive persons remains unclear. Methods: Poisson regression was used to compare incidence rates of DM (blood glucose >11.1 mmol/L, HbA1C >6.5% or >48 mmol/mol, starting antidiabetic medicine or physician reported date of DM onset) between current HIV/HCV groups (anti-HCV-negative, spontaneously cleared HCV, chronic untreated HCV, successfully treated HCV, HCV-RNA-positive after HCV treatment)...
December 2020: Open Forum Infectious Diseases
https://read.qxmd.com/read/33288230/-covid-19-still-a-place-for-tocilizumab
#39
JOURNAL ARTICLE
Q Richier, L Plaçais, K Lacombe, O Hermine
No abstract text is available yet for this article.
November 27, 2020: La Revue de Médecine Interne
https://read.qxmd.com/read/33033018/the-seattle-flu-study-a-multiarm-community-based-prospective-study-protocol-for-assessing-influenza-prevalence-transmission-and-genomic-epidemiology
#40
JOURNAL ARTICLE
Helen Y Chu, Michael Boeckh, Janet A Englund, Michael Famulare, Barry Lutz, Deborah A Nickerson, Mark Rieder, Lea M Starita, Amanda Adler, Elisabeth Brandstetter, Chris D Frazer, Peter D Han, Reena K Gulati, James Hadfield, Michael Jackson, Anahita Kiavand, Louise E Kimball, Kirsten Lacombe, Kira Newman, Thomas R Sibley, Jennifer K Logue, Victoria Rachel Lyon, Caitlin R Wolf, Monica Zigman Suchsland, Jay Shendure, Trevor Bedford
INTRODUCTION: Influenza epidemics and pandemics cause significant morbidity and mortality. An effective response to a potential pandemic requires the infrastructure to rapidly detect, characterise, and potentially contain new and emerging influenza strains at both an individual and population level. The objective of this study is to use data gathered simultaneously from community and hospital sites to develop a model of how influenza enters and spreads in a population. METHODS AND ANALYSIS: Starting in the 2018-2019 season, we have been enrolling individuals with acute respiratory illness from community sites throughout the Seattle metropolitan area, including clinics, childcare facilities, Seattle-Tacoma International Airport, workplaces, college campuses and homeless shelters...
October 7, 2020: BMJ Open
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