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ischemia reperfusion injury liver

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https://www.readbyqxmd.com/read/28930961/impact-of-a-novel-phosphoinositol-3-kinase-inhibitor-in-preventing-mitochondrial-dna-damage-and-damage-associated-molecular-pattern-accumulation-results-from-the-biochronicity-project
#1
George Edward Black, Kyle K Sokol, Donald M Moe, Jon D Simmons, David Muscat, Victor Pastukh, Gina Capley, Olena Gorodnya, Mykhaylo Ruchko, Mark B Roth, Mark Gillespie, Matthew J Martin
BACKGROUND: Despite improvements in the management of severely injured patients, development of multiple organ dysfunction syndrome (MODS) remains a morbid complication of traumatic shock. One of the key attributes of MODS is a profound bioenergetics crisis, for which the mediators and mechanisms are poorly understood. We hypothesized that metabolic uncoupling using an experimental phosphoinositol-3 kinase (PI3-K) inhibitor, LY294002 (LY), may prevent mitochondrial abnormalities that lead to the generation of mitochondrial DNA (mtDNA) damage and the release of mtDNA damage-associated molecular patterns (DAMPs)...
October 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28928734/c3a-enhances-the-formation-of-intestinal-organoids-through-c3ar1
#2
Naoya Matsumoto, Abhigyan Satyam, Mayya Geha, Peter H Lapchak, Jurandir J Dalle Lucca, Maria G Tsokos, George C Tsokos
C3a is important in the regulation of the immune response as well as in the development of organ inflammation and injury. Furthermore, C3a contributes to liver regeneration but its role in intestinal stem cell function has not been studied. We hypothesized that C3a is important for intestinal repair and regeneration. Intestinal organoid formation, a measure of stem cell capacity, was significantly limited in C3-deficient and C3a receptor (C3aR) 1-deficient mice while C3a promoted the growth of organoids from normal mice by supporting Wnt-signaling but not from C3aR1-deficient mice...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28920945/neutrophils-a-cornerstone-of-liver-ischemia-and-reperfusion-injury
#3
Thiago Henrique Caldeira de Oliveira, Pedro Elias Marques, Paul Proost, Mauro Martins M Teixeira
Ischemia-reperfusion injury (IRI) is the main cause of morbidity and mortality due to graft rejection after liver transplantation. During IRI, an intense inflammatory process occurs in the liver. This hepatic inflammation is initiated by the ischemic period but occurs mainly during the reperfusion phase, and is characterized by a large neutrophil recruitment to the liver. Production of cytokines, chemokines, and danger signals results in activation of resident hepatocytes, leukocytes, and Kupffer cells. The role of neutrophils as the main amplifiers of liver injury in IRI has been recognized in many publications...
September 18, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28901794/silybin-against-liver-ischemia-reperfusion-injury-something-old-something-new%C3%A2
#4
Mihai Oltean
Ischemia reperfusion injury (IRI) is a life threatening condition that may develop after elective liver surgery or liver transplantation. Numerous surgical and pharmacological approaches have shown varying degrees of protection against liver IRI. A group of protective compounds are the flavonoids but their intestinal absorbtion and bioavailability are low and impredictible. In this issue Tsaroucha et al. reports significantly decreased hepatocellular injury, Fas/FasL expression and inhibited HMGB1 release in rats receiving a hydrosoluble, lyophilized complex of SLB and hydroxypropyl-β-cyclodextrin (SLB-HP-β-CD) intravenously...
September 13, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28901476/dadle-improves-hepatic-ischemia-reperfusion-injury-in-mice-via-activation-of-the-nrf2-ho%C3%A2-1-pathway
#5
Yi Zhou, Jing Zhang, Biao Lei, Wenjin Liang, Jianhua Gong, Chuanxiang Zhao, Jidong Yu, Xuan Li, Bo Tang, Shengguang Yuan
Hepatic ischemia/reperfusion (I/R) injury is a common pathophysiological process that occurs following liver surgery, which is associated with oxidative stress, and can cause acute liver injury and lead to liver failure. Recently, the development of drugs for the prevention of hepatic I/R injury has garnered interest in the field of liver protection research. Previous studies have demonstrated that [D‑Ala2, D‑Leu5]‑Enkephalin (DADLE) exerts protective effects against hepatic I/R injury. To further clarify the specific mechanism underlying the effects of DADLE on hepatic I/R injury, the present study aimed to observe the effects of various doses of DADLE on hepatic I/R injury in mice...
August 29, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28893351/hepatic-ischemia-reperfusion-mechanisms-of-tissue-injury-repair-and-regeneration
#6
Takanori Konishi, Alex Lentsch
Hepatic ischemia reperfusion (I/R) injury is a major complication of liver surgery, including liver resection, liver transplantation, and trauma surgery. Much has been learned about the inflammatory injury response induced by I/R, including the cascade of proinflammatory mediators and recruitment of activated leukocytes. In this review, we discuss the complex network of events that culminate in liver injury after I/R, including cellular, protein, and molecular mechanisms. In addition we address the known endogenous regulatory mediators that function to maintain homeostasis and resolve injury...
September 11, 2017: Gene Expression
https://www.readbyqxmd.com/read/28887256/remote-ischemic-preconditioning-decreases-the-magnitude-of-hepatic-ischemia-reperfusion-injury-on-a-swine-model-of-supraceliac-aortic-cross-clamping
#7
G Martikos, A Kapelouzou, M Peroulis, A Paspala, D Athanasiadis, A Maheras, T D Liakakos, K Moulakakis, S Vasdekis, A M Lazaris
BACKGROUND: Temporary hepatic ischemia is inevitable during open aortic surgery when supraceliac clamping is necessary, as in thoracoabdominal or pararenal aneurysms. Remote ischemic preconditioning (RIPC) has been described as a potential protective means against ischemia - reperfusion injury (IRI) in various tissues including the liver. The aim of this experimental study was to detect the effect of RIPC on liver IRI in a model of supraceliac aortic cross-clamping. METHODS: An animal study was performed...
September 5, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28887166/dusp14-protects-against-hepatic-ischemia-reperfusion-injury-via-tak1-suppression
#8
Xiaozhan Wang, Wenzhe Mao, Chun Fang, Song Tian, Xueyong Zhu, Ling Yang, Zan Huang, Hongliang Li
BACKGROUND AND AIMS: Hepatic ischemia-reperfusion (I/R) injury is characterized by severe inflammation and extensive cell death. Multiple signaling pathways, including NF-κB and MAPK/Jnk, play important roles in this process. Identifying the unknown critical regulators of these signaling pathways may provide potential targets for therapeutic application. Dual specific phosphatase 14 (DUSP14) acts as a negative regulator of NF-κB signaling. However, the function of Dusp14 in hepatic I/R injury remains unknown...
September 5, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28885495/isoglycyrrhizinate-magnesium-enhances-hepatoprotective-effect-of-fk506-on-ischemia-reperfusion-injury-through-hmgb1-inhibition-in-a-rat-model-of-liver-transplantation
#9
Zhang Weichen, Li Feibo, Ye Yufu, Liu Yuanxing, Yu Songfeng, Cen Chao, Chen Xuliang, Zhou Lin, Tang Xiaofeng, Yu Jun, Zheng Shusen
BACKGROUND: Ischemia-reperfusion injury (IRI) after liver transplantation impairs graft function and affects prognosis of recipients. Isoglycyrrhizinate magnesium (Iso) is a hepatoprotective drug usually used after liver injury. In this study, we intended to explore whether Iso alone have protective effect after IRI in a rat model of liver transplantataion. We also aimed to study whether Iso could enhance the hepatoprotective effect of FK506 (tacrolimus) and underlying mechanism. METHODS: Rats after liver transplantation were treated with different concentration of FK506 with or without, Iso or lower-dose FK506 plus Iso...
September 6, 2017: Transplantation
https://www.readbyqxmd.com/read/28884828/neutrophil-extracellular-traps-in-acrolein-promoted-hepatic-ischemia-reperfusion-injury-therapeutic-potential-of-nox2-and-p38mapk-inhibitors
#10
Arumugam Suyavaran, Kesthuru Subbiah Girish, K Kemparaju, Chinnasamy Thirunavukkarasu
Neutrophil is a significant contributor to ischemia reperfusion (IR) induced liver tissue damage. However, the underlying mechanisms of IR induced innate immune activation and liver damage is not quite clear. Our study sheds light on the role of chronic oxidative stress end products in worsening the IR inflammatory process by neutrophil recruitment and activation following liver surgery. We employed specific inhibitors for molecular targets - NOX2 (NADPH oxidase 2) and P38 MAPK (Mitogen activated protein kinase) signal to counteract neutrophil activation and neutrophil extracellular trap (NET) release induced liver damage in IR injury...
September 8, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28880403/natural-igm-initiates-an-inflammatory-response-important-for-both-hepatic-ischemia-reperfusion-injury-and-regeneration
#11
Keely Marshall, Junfei Jin, Carl Atkinson, Ali Alawieh, Fei Qiao, Biao Lei, Kenneth D Chavin, Songqing He, Stephen Tomlinson
RATIONALE: Complement plays a role in both hepatic ischemia reperfusion (IR) injury (IRI) and liver regeneration, but it is not clear how complement is activated in either process. We investigated the role of self-reactive IgM antibodies in activating complement after hepatic IR and liver resection. MAIN RESULTS: Natural IgM antibodies that recognize danger associated molecular patterns (neoepitopes) activate complement following both hepatic IR and liver resection...
September 7, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28877040/ischemic-conditioning-in-solid-organ-transplantation-is-it-worth-giving-your-right-arm-for
#12
Luxme Nadarajah, Muhammed M Yaqoob, Kieran McCafferty
PURPOSE OF REVIEW: Ischemia reperfusion injury (IRI) is an inevitable complication in solid organ transplantation. Limiting this injury can increase patient and graft survival and can decrease complications associated with transplantation. We provide an extensive literature review analyzing the available evidence for ischemic conditioning in solid organ transplantation, including kidney, liver, heart, and lung. RECENT FINDINGS: Ischemic conditioning strategies are a group of interventions, characterized by episodes of ischemia and reperfusion to an organ which confirm tissue protection...
September 5, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28861157/tim-1-attenuates-the-protection-of-ischemic-preconditioning-for-ischemia-reperfusion-injury-in-liver-transplantation
#13
Yu Zhang, Yuanxing Liu, Hui Chen, Xiaoxiao Zheng, Shangzhi Xie, Wei Chen, Haofeng Ji, Shusen Zheng
Ischemic preconditioning (IPC) has been introduced to protect grafts against ischemic reperfusion injury (IRI) during liver transplantation (LT) in recent years. However, the underlying molecular mechanisms of IPC are not fully understood. We aimed to confirm whether the efficacy of IPC is dependent on T cell Immunoglobulin and Mucin domain-containing molecules-1 (TIM-1). Quantitative real-time reverse transcription PCR and western blotting were used to detect the expression of genes of interest. Graft function was assessed using the levels of alanine transaminase (ALT) and aspartate transaminase (AST), percentage of apoptosis cells and pathological examination...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28857857/isoflurane-preconditioning-alleviated-murine-liver-ischemia-and-reperfusion-injury-by-restoring-ampk-mtor-mediated-autophagy
#14
Zhuqing Rao, Xiongxiong Pan, Hui Zhang, Jie Sun, Jingjin Li, Ting Lu, Mei Gao, Siying Liu, Dan Yu, Zhengnian Ding
BACKGROUND: Isoflurane has a pharmacological preconditioning effect against ischemia injury in the heart, kidney, and brain, but whether and how isoflurane preconditioning protects livers against ischemia and reperfusion (IR) injury is unclear. METHODS: Mice were randomly divided into an isoflurane preconditioning (ISO) group and control group, receiving 1.5% isoflurane or carrier gas for 40 minutes, respectively (n = 8/group). A partial warm liver IR model was used, and liver injury was evaluated...
October 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28854316/remnant-liver-ischemia-as-a-prognostic-factor-for-cancer-specific-survival-after-resection-of-colorectal-liver-metastases
#15
Suguru Yamashita, Aradhana M Venkatesan, Takashi Mizuno, Thomas A Aloia, Yun S Chun, Jeffrey E Lee, Jean-Nicolas Vauthey, Claudius Conrad
Importance: Ischemia-reperfusion injury during hepatic resection has been shown to accelerate progression of liver cancer. However, the prognostic relevance of remnant liver ischemia (RLI) after resection of colorectal liver metastases (CLMs) is unknown to date. Objectives: To assess the prognostic influence of RLI after resection of CLMs and to identify correlates of greater extent of RLI. Design, Setting, and Participants: This study was a retrospective analysis at The University of Texas MD Anderson Cancer Center based on prospectively collected data...
August 30, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28851669/nrf2-inhibits-nlrp3-inflammasome-activation-through-regulating-trx1-txnip-complex-in-cerebral-ischemia-reperfusion-injury
#16
Yanghao Hou, Yueting Wang, Qi He, Lingyu Li, Hui Xie, Yong Zhao, Jing Zhao
The nod-like receptor protein 3 (NLRP3) inflammasome has a critical role in inflammation damage in ischemic injury, and the activation of the inflammasome is closely related to the interaction with thioredoxin interacting protein (TXNIP), which dissociates from the thioredoxin1 (Trx1)/TXNIP complex under oxidative stress. However, the negative regulator of NLRP3 inflammasome activation has not been fully investigated. Nuclear factor erythroid 2-related factor 2 (Nrf2) takes on a critical part in the antioxidant stress system, that controls the driven genes of antioxidant response element (ARE)...
August 26, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28842295/macrophage-heme-oxygenase-1-sirt1-p53-axis-regulates-sterile-inflammation-in-liver-ischemia-reperfusion-injury
#17
Kojiro Nakamura, Min Zhang, Shoichi Kageyama, Bibo Ke, Takehiro Fujii, Rebecca A Sosa, Elaine F Reed, Nakul Datta, Ali Zarrinpar, Ronald W Busuttil, Jesus A Araujo, Jerzy W Kupiec-Weglinski
BACKGROUND &AIMS: Hepatic ischemia-reperfusion injury (IRI), an exogenous antigen-independent local inflammation and hepatocellular death, represents a risk factor for acute and chronic rejection in liver transplantation. METHODS: To gain insights into molecular communication in the mechanism of liver IRI, we analyzed human liver transplants in parallel with primary murine macrophage cell cultures and IR-stressed livers in myeloid-specific HO-1 (heme oxygenase-1) gene mutant mice for anti-inflammatory and cytoprotective functions of macrophage-specific HO-1 / SIRT1 (sirtuin 1) / p53 (tumor suppressor protein) signaling RESULTS: Decreased HO-1 expression in human post-reperfusion liver transplant biopsies correlated with deteriorated hepatocellular function (serum ALT; p<0...
August 23, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28837866/protective-effect-of-aspirin-triggered-resolvin-d1-on-hepatic-ischemia-reperfusion-injury-in-rats-the-role-of-mir-146b
#18
Tao Zhang, Huan-Huan Xiu, Jia-Xin Liu, Yi Ma, Kang-Qing Xu, Wen-Qi Huang
PURPOSE: Inflammatory responses play an important role in the tissue injury during liver ischemia/reperfusion (I/R). We previously reported that resolvin D1 (RvD1) administrated prior to hepatic I/R attenuates liver injury through inhibition of inflammatory response. In this study, we investigated the effects of the aspirin-triggered resolvin D1 (AT-RvD1) on hepatic I/R and the role of miR-146b in this process. METHODS: Partial warm ischemia was performed in the left and middle hepatic lobes of Sprague-Dawley rats for 1h, followed by 6h of reperfusion...
August 21, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28832798/avoiding-liver-injury-with-papaverine-and-ascorbic-acid-due-to-infrarenal-cross-clamping-an-experimental-study
#19
Serhat Huseyin, Orkut Guclu, Volkan Yüksel, Gulen Sezer Alptekin Erkul, Nuray Can, Fatma Nesrin Turan, Suat Canbaz
Objective: Ischemia-reperfusion injury after acute ischemia treatment is a serious condition with high mortality and morbidity. Ischemia-reperfusion injury may result in organ failure particularly in kidney, lung, liver, and heart. In our study, we investigated the effects of papaverine and vitamin C on ischemia-reperfusion injury developed in the rat liver after occlusion-reperfusion of rat aorta. Methods: 32 Sprague-Dawley female rats were randomized into four groups (n=8)...
May 2017: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28829487/effect-and-mechanism-of-propofol-in-hepatic-ischemia-reperfusion-injury-of-rat
#20
L Wei, W-Y Chen, T Hu, Y-X Tang, B-B Pan, M Jin, G-Y Kong
OBJECTIVE: Hepatic ischemia/reperfusion (I/R) injury remains to be one of the most common clinical diseases. This study aimed to explore the potential effect and mechanism of propofol in protecting rat liver from I/R injury. MATERIALS AND METHODS: The hepatic I/R model was established in Sprague-Dawley (SD) rats by perfusing the liver with heparinized cold saline through the portal vein for 20 min. The rats were then received a 100 mg/kg/d propofol administration for the continuously 10 days...
August 2017: European Review for Medical and Pharmacological Sciences
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