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ischemia reperfusion injury liver

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https://www.readbyqxmd.com/read/29331341/effects-of-the-gut-liver-axis-on-ischemia-mediated-hepatocellular-carcinoma-recurrence-in-the-mouse-liver
#1
Lorenzo A Orci, Stéphanie Lacotte, Vaihere Delaune, Florence Slits, Graziano Oldani, Vladimir Lazarevic, Carlo Rossetti, Laura Rubbia-Brandt, Philippe Morel, Christian Toso
BACKGROUND & AIMS: There is growing evidence that liver graft ischemia-reperfusion (I/R) is a risk factor for hepatocellular carcinoma (HCC) recurrence, but the involved mechanisms are unclear. Here, we tested the hypothesis that mesenteric congestion due to portal blood flow interruption induces endotoxin-mediated Toll-Like Receptor 4 (Tlr4) engagement, resulting in elevated liver cancer burden. We also assessed the role of remote ischemic preconditioning (RIPC) in this context. METHODS: C57Bl/6j mice were exposed to standardized models of liver I/R injury and RIPC, by occluding hepatic and femoral blood vessels...
January 10, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29328470/cobalt-protoporphyrin-enhances-heme-oxygenase-1-expression-and-attenuates-liver-ischemia-reperfusion-injury-by-inhibiting-apoptosis
#2
Jing Li, Bin Wu, Dahong Teng, Xiaoye Sun, Junjie Li, Jiang Li, Guoliang Zhang, Jinzhen Cai
The aim of the present study was to investigate the preconditioning effect and underlying mechanisms of cobalt-protoporphyrin (CoPP) in a mouse model of liver ischemia‑reperfusion (I/R) injury. Mice were divided into five groups: Sham‑operated (control), I/R, I/R + CoPP, I/R + CoPP and zinc‑protoporphyrin (ZnPP) and I/R + ZnPP. Serum levels of aspartate transaminase (AST) and alanine aminotransferase (ALT) were detected using commercial kits. The expression of the pro‑apoptotic protein caspase‑3 was detected by immunohistochemistry and the expression levels of the anti‑apoptotic protein B‑cell lymphoma 2 (Bcl‑2) and heme oxygenase 1 (HO‑1) were analyzed by western blotting...
January 5, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29311400/hypericum-humifusum-leaves-attenuates-hepatic-ischemia-reperfusion-injury-in-a-rat-model
#3
Henda Ferchichi, Issam Salouage, Sarra Bacha, Nadia Kourda, Nadia Jebabli, Emna Gaies, Anis Klouz, Sameh Trabelsi
INTRODUCTION: Effective prevention strategies require specific actions during the different phases of ischemia-reperfusion (I-R) injury. The objective of our study is to evaluate the effect of aqueous extract of Hypericum humifusum leaves (HHL) on liver I-R model in Rat. MATERIAL AND METHODS: Animals were subjected to 90 min of hepatic ischemia followed by reperfusion (120 min). HHL extract (25 mg/mL/kg) was injected 15 min before reperfusion. To evaluate the effect of HHL extract on I-R, we have monitored transaminases levels, Malondialdehyde (MDA) concentration, histological lesions (apoptosis and necrosis) and compared the results to a reference oxidant vitamin E...
December 27, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29310325/meta-analysis-of-ischemic-preconditioning-ip-on-postoperative-outcomes-after-liver-resections
#4
Xingjun Guo, Gongpan Liu, Xiaobin Zhang
BACKGROUND: The protective role (decrease ischemia-reperfusion injury) of ischemic preconditioning (IP) before continuous vascular occlusion in liver resection is controversial. This meta-analysis aimed to compare the advantages and any potential disadvantages of IP maneuver. METHODS: A systematic search in the Embase, Medline, PubMed databases, and the Cochrane Library was performed using both medical subject headings (MeSH) and truncated word searches to identify all randomized controlled trials (RCTs) published on this topic...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29306480/corrigendum-to-induction-of-autophagy-reduces-ischemia-reperfusion-injury-in-steatotic-rat-livers-journal-of-surgical-research-216-2017-207-218
#5
Chunyi Kan, Anding Liu, Haoshu Fang, Olaf Dirsch, Uta Dahmen, Michael Boettcher
No abstract text is available yet for this article.
January 3, 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29305862/stim1-deficiency-protects-the-liver-from-ischemia-reperfusion-injury-in-mice
#6
Yanyang Li, Chunyan Lou, Weiying Wang
Hepatic ischemia reperfusion (I/R) injury is unavoidable in various clinical conditions. Despite considerable investigation, the underlying molecular mechanism revealing liver I/R injury remains elusive. Stromal interaction molecule 1 (STIM1) plays essential role in regulating the induction of cellular responses to a number of stress conditions, including temperature changes, elevated ROS, and hypoxia. Here, to explore if STIM1 is involved in hepatic injury, wild type (WT) and STIM1-knockout (STIM1-/-) mice were subjected to I/R...
January 3, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29302794/evaluation-of-the-neuroprotective-effect-of-sirt3-in-experimental-stroke
#7
Rajkumar Verma, Rodney M Ritzel, Joshua Crapser, Brett D Friedler, Louise D McCullough
Sirtuins (Sirt) are a family of NAD+ dependent histone deacetylase (HDAC) proteins implicated in aging, cell cycle regulation, and metabolism. These proteins are involved in the epigenetic modification of neuromodulatory proteins after strokevia acetylation/deacetylation. The specific role of Sirt3, a mitochondrial sirtuin, in post-stroke injury has been relatively unexplored. Using male Sirt3 knockout (KO) mice and wild-type littermates (WT), we show that Sirt3 KO mice show significant neuroprotection at 3 days after ischemia/reperfusion (I/R) or stroke injury...
January 4, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29302205/endogenous-agmatine-induced-by-ischemic-preconditioning-regulates-ischemic-tolerance-following-cerebral-ischemia
#8
Jae Hwan Kim, Jae Young Kim, Jin Young Jung, Yong Woo Lee, Won Taek Lee, Seung Kon Huh, Jong Eun Lee
Ischemic preconditioning (IP) is one of the most important endogenous mechanisms that protect the cells against ischemia-reperfusion (I/R) injury. However, the exact molecular mechanisms remain unclear. In this study, we showed that changes in the level of agmatine were correlated with ischemic tolerance. Changes in brain edema, infarct volume, level of agmatine, and expression of arginine decarboxylase (ADC) and nitric oxide synthases (NOS; inducible NOS [iNOS] and neural NOS [nNOS]) were analyzed during I/R injury with or without IP in the rat brain...
December 2017: Experimental Neurobiology
https://www.readbyqxmd.com/read/29290907/morphological-alterations-and-redox-changes-associated-with-hepatic-warm-ischemia-reperfusion-injury
#9
Rim Jawad, Melroy D'souza, Lisa Arodin Selenius, Marita Wallenberg Lundgren, Olof Danielsson, Greg Nowak, Mikael Björnstedt, Bengt Isaksson
AIM: To study the effects of warm ischemia-reperfusion (I/R) injury on hepatic morphology at the ultrastructural level and to analyze the expression of the thioredoxin (TRX) and glutaredoxin (GRX) systems. METHODS: Eleven patients undergoing liver resection were subjected to portal triad clamping (PTC). Liver biopsies were collected at three time points; first prior to PTC (baseline), 20 min after PTC (post-ischemia) and 20 min after reperfusion (post-reperfusion)...
December 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/29286833/liver-x-receptors-activation-attenuates-ischemia-reperfusion-injury-of-liver-graft-in-rats
#10
Ming-Xiang Cheng, Ping Huang, Qiang He, Yong Chen, Jin-Zheng Li
PURPOSE: Suppression of the Toll like receptor 4 (TLR4)-nuclear factor-κB (NF-κB) signaling was critical in protection against liver IRI. Previous studies revealed that Liver X receptors (LXRs) activation could antagonize TLR4-NF-κB signaling. The purpose of this study is to determine whether LXRs agonist GW3965 can suppress the TLR4-NF-κB signaling during liver transplantation and protect ischemia-reperfusion injury (IRI). MATERIALS AND METHODS: Sprague Dawley (SD) rats were used to perform orthotropic liver transplantation...
December 29, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29278454/hypothermic-machine-perfusion-in-liver-transplantation
#11
R Cutler Quillin, James V Guarrera
A finite supply of donor organs has led many transplant centers to accept marginal liver allografts with increasing frequency. These allografts may be at higher risk of primary non-function, early allograft dysfunction and other recipient complications following liver transplantation. Machine perfusion preservation is an emerging technology that limits ischemia-reperfusion injury associated with preservation and may lead to improved outcomes following transplantation. Increased used of machine perfusion in liver preservation may permit an expansion of the donor pool...
December 26, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29273372/preischemic-transfusion-of-old-packed-rbcs-exacerbates-early-phase-warm-hepatic-ischemia-reperfusion-injury-in-rats
#12
Eun Kyung Choi, Jongyoon Baek, Sangyoung Park, Suk Hwan Baek, Joon-Hyuk Choi, Chae Hoon Lee, Eon-Gi Sung, Daelim Jee
BACKGROUND: Hepatic innate immune cells are considered to play a central role in the early phase of hepatic ischemia reperfusion (IR) injury. Transfusion of old red blood cells (RBCs) is known to prime immune cells, and transfusion before IR may exacerbate liver injury because of the expected hyperresponsiveness of immune cells. MATERIALS AND METHODS: Twenty-four Sprague-Dawley rats were divided into four groups: sham operation (Sham); hepatic IR only (IR Control); and two transfusion groups, preischemic (Pre-T) and postischemic (Post-T), in which allogeneic RBCs stored for 2 weeks were transfused before hepatic IR or after reperfusion, respectively...
February 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29273365/sinusoidal-protection-by-sphingosine-1-phosphate-receptor-1-agonist-in-liver-ischemia-reperfusion-injury
#13
Takahiro Ito, Naohisa Kuriyama, Hiroyuki Kato, Akitoshi Matsuda, Shugo Mizuno, Masanobu Usui, Hiroyuki Sakurai, Shuji Isaji
BACKGROUND: Functional and structural damages in sinusoidal endothelial cells (SECs) have a crucial role during hepatic ischemia-reperfusion injury (IRI). In regulating endothelial function, sphingosine-1-phosphate receptor 1 (S1PR1), which is a G protein-coupled receptor, has an important role. The present study aimed to clarify whether SEW2871, a selective S1PR1 agonist, can attenuate hepatic damage caused by hepatic IRI, focusing on SEC functions. METHODS: In vivo, using a 60-min partial-warm IRI model, mice were treated with SEW2871 or without it (with vehicle)...
February 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29261831/evaluation-of-early-allograft-function-using-the-liver-graft-assessment-following-transplantation-risk-score-model
#14
Vatche G Agopian, Michael P Harlander-Locke, Daniela Markovic, Wethit Dumronggittigule, Victor Xia, Fady M Kaldas, Ali Zarrinpar, Hasan Yersiz, Douglas G Farmer, Jonathan R Hiatt, Ronald W Busuttil
Importance: Early allograft dysfunction (EAD) following a liver transplant (LT) unequivocally portends adverse graft and patient outcomes, but a widely accepted classification or grading system is lacking. Objective: To develop a model for individualized risk estimation of graft failure after LT and then compare the model's prognostic performance with the existing binary EAD definition (bilirubin level of ≥10 mg/dL on postoperative day 7, international normalized ratio of ≥1...
December 20, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29251315/hepatic-recruitment-of-cd11b-ly6c-inflammatory-monocytes-promotes-hepatic-ischemia-reperfusion-injury
#15
Peng Song, Junbin Zhang, Yunwei Zhang, Zhiping Shu, Peng Xu, Long He, Chao Yang, Jinxiang Zhang, Hui Wang, Yiqing Li, Qin Li
Monocytes infiltrate damaged liver tissue during noninfectious liver injury and often have dual roles, perpetuating inflammation and promoting resolution of inflammation and fibrosis. However, how monocyte subsets distribute and are differentially recruited in the liver remain unclear. In the current study, the subpopulations of infiltrating monocytes were examined following liver ischemia/reperfusion (I/R) injury in mice using flow cytometry. CD11b+Ly6C high (Ly6Chi) cells (inflammatory monocytes) and CD11b+Ly6C low cells (reparative monocytes) were recruited into the liver following I/R injury...
February 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29246201/multiparametric-functional-magnetic-resonance-imaging-for-evaluation-of-hepatic-warm-ischemia-reperfusion-injury-in-a-rabbit-model
#16
Qian Ji, Zhi Qiang Chu, Tao Ren, Shi Chao Xu, Long Jiang Zhang, Wen Shen, Guang Ming Lu
BACKGROUND: To assess the feasibility of noninvasive and quantitative evaluation of hepatic pathophysiological changes in rabbit hepatic warm ischemia-reperfusion injury (WIRI) models by using intravoxel incoherent motion (IVIM), diffusion tensor imaging (DTI) and blood oxygen level dependent (BOLD) MRI. METHODS: Twenty rabbits were randomly divided into hepatic WIRI model group and sham-operation group (n = 10 for each group). Hepatic WIRI was induced in rabbit by occluding hepatic inflow for 30 min and reperfusion for 6 h...
December 15, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29236799/perconditioning-associated-to-hypertonic-saline-solution-on-liver-function-improvement-after-ischemia-reperfusion-injury
#17
Rubens Fernando Gonçalves Ribeiro, Rodrigo Paracampo Couteiro, Andrew Moraes Monteiro, Ivone Aline da Silva Rodrigues, Lainy Carollyne da Costa Cavalcante, Eduardo Henrique Herbster Gouveia, Lucas Nascimento Galvão, Luiz Renato Oliveira Lopes, Edson Yuzur Yasojima, Marcus Vinicius Henriques Brito
PURPOSE: To evaluate the effects of hypertonic saline solution associated to remote ischemic perconditioning in liver ischemia/reperfusion injury in rats. METHODS: 25 male rats (Wistar) were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of liver ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during liver ischemia; Hypertonic saline solution group (HSS) treated with hypertonic saline solution (4ml/kg); Remote ischemic perconditioning + Hypertonic saline solution group (Per+HSS) with both treatments...
November 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29230676/gut-microbial-balance-and-liver-transplantation-alteration-management-and-prediction
#18
REVIEW
Xinyao Tian, Zhe Yang, Fangzhou Luo, Shusen Zheng
Liver transplantation is a conventional treatment for terminal stage liver diseases. However, several complications still hinder the survival rate. Intestinal barrier destruction is widely observed among patients receiving liver transplant and suffering from ischemia-reperfusion or rejection injuries because of the relationship between the intestine and the liver, both in anatomy and function. Importantly, the resulting alteration of gut microbiota aggravates graft dysfunctions during the process. This article reviews the research progress for gut microbial alterations and liver transplantation...
December 12, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/29228666/granulocyte-colony-stimulating-factor-treatment-in-non-alcoholic-fatty-liver-disease-beyond-marrow-cell-mobilization
#19
Ho Hyun Nam, Dae Won Jun, Kiseok Jang, Waqar Khalid Saeed, Jai Sun Lee, Hyeon Tae Kang, Yeon Ji Chae
Protective effects of granulocyte colony stimulating factor (G-CSF) in acute liver injury via marrow cell mobilization have been reported in several studies. But exact mode of action and optimal protocol of G-CSF has been still doubt in chronic disease. Here we investigated mode of action and optimization of G-CSF as a treatment for non-alcoholic fatty liver disease (NAFLD). Various doses of conventional G-CSF (30 μg/kg once weekly, once daily for 5 days, twice weekly) and long acting G-CSF (30 μg/kg once a month) were evaluated in two kinds of NAFLD animal models to optimize the G-CSF protocol...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29227984/microrna-146b-5p-identified-in-porcine-liver-donation-model-is-associated-with-early-allograft-dysfunction-in-human-liver-transplantation
#20
Cheukfai Li, Qiang Zhao, Wei Zhang, Maogen Chen, Weiqiang Ju, Linwei Wu, Ming Han, Yi Ma, Xiaofeng Zhu, Dongping Wang, Zhiyong Guo, Xiaoshun He
BACKGROUND Poor transplant outcome was observed in donation after brain death followed by circulatory death (DBCD), since the donor organs suffered both cytokine storm of brain death and warm ischemia injury. MicroRNAs (miRNAs) have emerged as promising disease biomarkers, so we sought to establish a miRNA signature of porcine DBCD and verify the findings in human liver transplantation. MATERIAL AND METHODS MiRNA expression was determined with miRNA sequencing in 3 types of the porcine model of organ donation, including donation after brain death (DBD) group, donation after circulatory death (DCD) group, and DBCD group...
December 11, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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