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JOURNAL ARTICLE
R Gentry Wilkerson, Youssef Annous, Eli Farhy, Jonathan Hurst, Angela D Smedley
OBJECTIVES: Patients with suspected COVID-19 remain at risk for clinical deterioration after discharge and may benefit from home oxygen saturation (SpO2 ) monitoring using portable pulse oximeter devices. Our study aims to evaluate patient engagement and compliance with a home SpO2 monitoring program. METHODS: This is a single center, prospective pilot study of patients being discharged from the ED or urgent care after evaluation of symptoms consistent with COVID-19...
June 26, 2023: Health Policy and Technology
#2
JOURNAL ARTICLE
Wayne A Ray, Cecilia P Chung, C Michael Stein, Walter Smalley, Eli Zimmerman, William D Dupont, Adriana M Hung, James R Daugherty, Alyson Dickson, Katherine T Murray
IMPORTANCE: Diltiazem, a commonly prescribed ventricular rate-control medication for patients with atrial fibrillation, inhibits apixaban and rivaroxaban elimination, possibly causing overanticoagulation. OBJECTIVE: To compare serious bleeding risk for new users of apixaban or rivaroxaban with atrial fibrillation treated with diltiazem or metoprolol. DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study included Medicare beneficiaries aged 65 years or older with atrial fibrillation who initiated apixaban or rivaroxaban use and also began treatment with diltiazem or metoprolol between January 1, 2012, and November 29, 2020...
April 15, 2024: JAMA
#3
JOURNAL ARTICLE
Avinash Mishra, Anchal Tripathi, Atul Bhirud, Mohini Agrawal, Sandeep Gupta, Jks Parihar
Purpose: To report patients who first presented with various ocular manifestations and eventually ascertained to have underlying dengue. Methods: A prospective study was conducted at multiple tertiary eye-care centers in India from 2012 to 2022. Cases reporting initially with ocular features along with fever/past history of fever over the last two weeks or with clinical features of dengue were selected. After an ophthalmological examination, patients underwent complete serological and biochemical analysis and those with reduced platelet counts were evaluated for dengue...
2024: Romanian Journal of Ophthalmology
#4
Elie Adam, Marek Kowalski, Oluwaseun Akeju, Earl K Miller, Emery N Brown, Michelle M McCarthy, Nancy Kopell
Ketamine is an NMDA-receptor antagonist that produces sedation, analgesia and dissociation at low doses and profound unconsciousness with antinociception at high doses. At high and low doses, ketamine can generate gamma oscillations ( > 25 Hz) in the electroencephalogram (EEG). The gamma oscillations are interrupted by slow-delta oscillations (0.1-4 Hz) at high doses. Ketamine's primary molecular targets and its oscillatory dynamics have been characterized. However, how the actions of ketamine at the subcellular level give rise to the oscillatory dynamics observed at the network level remains unknown...
April 5, 2024: bioRxiv
#5
JOURNAL ARTICLE
Hugo Lopez, Angela Botticella, Farid Belkhir, Benjamin Besse, Elie Fadel, Olaf Mercier, Antonin Levy, Cécile Le Péchoux
PURPOSE: To assess the prognostic factors and patterns of failure of patients consecutively treated with surgery and postoperative radiation therapy (PORT) for thymic epithelial tumours (TET). PATIENTS AND METHODS: Data from 192 TET patients who were operated and received PORT at a single centre from 1990 to 2019 was retrospectively analysed. RESULTS: Most patients had thymoma (77 %, B247%), were classified Masaoka-Koga stage III (35 %) or IV (32 %) and had a R0 (75 %) resection...
April 11, 2024: Radiotherapy and Oncology
#6
JOURNAL ARTICLE
Reem A Mustafa, Ibrahim K El Mikati, M Hassan Murad, Monica Hultcrantz, Karen R Steingart, Bada Yang, Mariska M G Leeflang, Elie A Akl, Philipp Dahm, Holger J Schünemann
OBJECTIVES: To provide guidance on rating imprecision in a body of evidence assessing the accuracy of a single test. This guide will clarify when Grading of Recommendations Assessment, Development and Evaluation (GRADE) users should consider rating down the certainty of evidence by one or more levels for imprecision in test accuracy. STUDY DESIGN AND SETTING: A project group within the GRADE working group conducted iterative discussions and presentations at GRADE working group meetings to produce this guidance...
January 2024: Journal of Clinical Epidemiology
#7
JOURNAL ARTICLE
Arnon Elizur, Shirel Rachel-Jossefi, Marianna Rachmiel, Eli Eisenberg, Yitzhak Katz
BACKGROUND: The effect of the amount of transient cow's milk formula (CMF) consumed during the first days of life on IgE-cow's milk allergy (IgE-CMA) is unknown. METHODS: A cohort of 58 patients with IgE-CMA was identified from a large scale population-based study of 13,019 infants followed from birth. A group of 116 infants matched for sex and breastfeeding only duration (beyond the nursery period), and another random group of 259 healthy infants were used as controls...
April 2024: Clinical and Translational Allergy
#8
JOURNAL ARTICLE
Joshua S Friedman, Benjamin H Durham, Anne S Reiner, Mariko Yabe, Kseniya Petrova-Drus, Ahmet Dogan, Melissa Pulitzer, Klaus J Busam, Jasmine H Francis, Raajit K Rampal, Gary A Ulaner, Ryan Reddy, Randy Yeh, Vaios Hatzoglou, Mario E Lacouture, Veronica Rotemberg, Roei D Mazor, Oshrat Hershkovitz-Rokah, Ofer Shpilberg, Gaurav Goyal, Ronald S Go, Jithma P Abeykoon, Karen Rech, Diana Morlote, Shiraz Fidai, Vedavyas Gannamani, Maryam Zia, Omar Abdel-Wahab, Katherine S Panageas, Marc K Rosenblum, Eli L Diamond
Histiocytic neoplasms are diverse clonal haematopoietic disorders, and clinical disease is mediated by tumorous infiltration as well as uncontrolled systemic inflammation. Individual subtypes include Langerhans cell histiocytosis (LCH), Rosai-Dorfman-Destombes disease (RDD) and Erdheim-Chester disease (ECD), and these have been characterized with respect to clinical phenotypes, driver mutations and treatment paradigms. Less is known about patients with mixed histiocytic neoplasms (MXH), that is two or more coexisting disorders...
April 12, 2024: British Journal of Haematology
#9
REVIEW
Anne-Gael Cordier, Elie Zerbib, Amélia Favier, Yohann Dabi, Emile Daraï
Pregnancy-related complications (PRC) impact maternal and fetal morbidity and mortality and place a huge burden on healthcare systems. Thus, effective diagnostic screening strategies are crucial. Currently, national and international guidelines define patients at low risk of PRC exclusively based on their history, thus excluding the possibility of identifying patients with de novo risk (patients without a history of disease), which represents most women. In this setting, previous studies have underlined the potential contribution of non-coding RNAs (ncRNAs) to detect patients at risk of PRC...
March 29, 2024: Diagnostics
#10
JOURNAL ARTICLE
Hadas Ben-Eli, Eyal Banin, Jaime Levy, Miryam Glik, Sarah Afriat, Yasmin Magal, Rivka Harari, Aviya Benyamin, Shira Shein, Itay Chowers
Background : Visual acuity (VA) assessments are crucial in ophthalmology but traditionally rely on in-clinic evaluations. The emergence of telemedicine has spurred interest in creating dependable self-administered VA tests for use beyond standard clinical environments. This study evaluated the practicality and validity of a self-administered near VA card test against traditional Snellen and Rosenbaum Pocket Vision Screener (RPVS) methods for home monitoring and enhancing clinical workflow. Methods : In a cross-sectional study, a near VA card (Hadassah Self-Visual Acuity Screener (HSVA)) was developed with written and videotaped instructions for self-use...
April 2, 2024: Journal of Clinical Medicine
#11
JOURNAL ARTICLE
Yuri Durodié, Thomas Decoster, Ben Van Herbruggen, Jono Vanhie-Van Gerwen, Eli De Poorter, Adrian Munteanu, Bram Vanderborght
Ultra-wideband (UWB) has gained increasing interest for providing real-time positioning to robots in GPS-denied environments. For a robot to act on this information, it also requires its heading. This is, however, not provided by UWB. To overcome this, either multiple tags are used to create a local reference frame connected to the robot or a single tag is combined with ego-motion estimation from odometry or Inertial Measurement Unit (IMU) measurements. Both odometry and the IMU suffer from drift, and it is common to use a magnetometer to correct the drift on the heading; however, magnetometers tend to become unreliable in typical GPS-denied environments...
March 28, 2024: Sensors
#12
JOURNAL ARTICLE
David J Eldridge, Jingyi Ding, Josh Dorrough, Manuel Delgado-Baquerizo, Osvaldo Sala, Nicolas Gross, Yoann Le Bagousse-Pinguet, Max Mallen-Cooper, Hugo Saiz, Sergio Asensio, Victoria Ochoa, Beatriz Gozalo, Emilio Guirado, Miguel García-Gómez, Enrique Valencia, Jaime Martínez-Valderrama, César Plaza, Mehdi Abedi, Negar Ahmadian, Rodrigo J Ahumada, Julio M Alcántara, Fateh Amghar, Luísa Azevedo, Farah Ben Salem, Miguel Berdugo, Niels Blaum, Bazartseren Boldgiv, Matthew Bowker, Donaldo Bran, Chongfeng Bu, Rafaella Canessa, Andrea P Castillo-Monroy, Ignacio Castro, Patricio Castro-Quezada, Simone Cesarz, Roukaya Chibani, Abel Augusto Conceição, Anthony Darrouzet-Nardi, Yvonne C Davila, Balázs Deák, Paloma Díaz-Martínez, David A Donoso, Andrew David Dougill, Jorge Durán, Nico Eisenhauer, Hamid Ejtehadi, Carlos Ivan Espinosa, Alex Fajardo, Mohammad Farzam, Ana Foronda, Jorgelina Franzese, Lauchlan H Fraser, Juan Gaitán, Katja Geissler, Sofía Laura Gonzalez, Elizabeth Gusman-Montalvan, Rosa Mary Hernández, Norbert Hölzel, Frederic Mendes Hughes, Oswaldo Jadan, Anke Jentsch, Mengchen Ju, Kudzai F Kaseke, Melanie Köbel, Anika Lehmann, Pierre Liancourt, Anja Linstädter, Michelle A Louw, Quanhui Ma, Mancha Mabaso, Gillian Maggs-Kölling, Thulani P Makhalanyane, Oumarou Malam Issa, Eugene Marais, Mitchel McClaran, Betty Mendoza, Vincent Mokoka, Juan P Mora, Gerardo Moreno, Seth Munson, Alice Nunes, Gabriel Oliva, Gastón R Oñatibia, Brooke Osborne, Guadalupe Peter, Margerie Pierre, Yolanda Pueyo, R Emiliano Quiroga, Sasha Reed, Ana Rey, Pedro Rey, Víctor Manuel Reyes Gómez, Víctor Rolo, Matthias C Rillig, Peter C le Roux, Jan Christian Ruppert, Ayman Salah, Phokgedi Julius Sebei, Anarmaa Sharkhuu, Ilan Stavi, Colton Stephens, Alberto L Teixido, Andrew David Thomas, Katja Tielbörger, Silvia Torres Robles, Samantha Travers, Orsolya Valkó, Liesbeth van den Brink, Frederike Velbert, Andreas von Heßberg, Wanyoike Wamiti, Deli Wang, Lixin Wang, Glenda M Wardle, Laura Yahdjian, Eli Zaady, Yuanming Zhang, Xiaobing Zhou, Fernando T Maestre
Perennial plants create productive and biodiverse hotspots, known as fertile islands, beneath their canopies. These hotspots largely determine the structure and functioning of drylands worldwide. Despite their ubiquity, the factors controlling fertile islands under conditions of contrasting grazing by livestock, the most prevalent land use in drylands, remain virtually unknown. Here we evaluated the relative importance of grazing pressure and herbivore type, climate and plant functional traits on 24 soil physical and chemical attributes that represent proxies of key ecosystem services related to decomposition, soil fertility, and soil and water conservation...
April 12, 2024: Nature Plants
#13
JOURNAL ARTICLE
Konsta Teppo, K E Juhani Airaksinen, Jussi Jaakkola, Olli Halminen, Birgitta Salmela, Elis Kouki, Jari Haukka, Jukka Putaala, Miika Linna, Aapo L Aro, Pirjo Mustonen, Juha Hartikainen, Gregory Y H Lip, Mika Lehto
BACKGROUND AND AIMS: Female sex has been linked with higher risk of ischaemic stroke (IS) in atrial fibrillation (AF), but no prior study has examined temporal trends in the IS risk associated with female sex. METHODS: The registry-linkage Finnish AntiCoagulation in Atrial Fibrillation (FinACAF) study included all patients with AF in Finland from 2007 to 2018. Ischaemic stroke rates and rate ratios were computed. RESULTS: Overall, 229 565 patients with new-onset AF were identified (50...
April 12, 2024: European Heart Journal
#14
JOURNAL ARTICLE
Sengo Kobayashi, Satoshi Okano
The effective use of oxygen as an alloying element in Ti alloys is attractive due to the reduction of production cost and the increase in strength and hardness of the alloy. Although the oxygen addition in a Ti alloy increases strength and hardness, it may induce brittleness. An appropriate combination of alloying elements and thermomechanical treatment must be clarified for the use of oxygen as an alloying element. Ti-(0, 1.0, 2.0, 3.0)Mo-(0, 1.5, 3.0)O alloys were developed, and their microstructure and mechanical properties were examined...
2024: Frontiers in Bioengineering and Biotechnology
#15
JOURNAL ARTICLE
Jeremy E Orr, Atul Malhotra, Eli Gruenberg, Traci Marin, Scott A Sands, Raichel M Alex, Robert L Owens, Christopher N Schmickl
STUDY OBJECTIVES: Opioid medications are commonly used and are known to impact both breathing and sleep, and are linked with adverse health outcomes including death. Clinical data indicate that chronic opioid use causes central sleep apnea, and might also worsen obstructive sleep apnea. The mechanisms by which opioids influence sleep-disordered breathing pathogenesis are not established. METHODS: Patients who underwent clinically-indicated polysomnography confirming sleep-disordered breathing (SDB) (AHI≥5/hr) were included...
April 12, 2024: Sleep
#16
JOURNAL ARTICLE
Christina James, Ulrike Möller, Christiane Spillner, Sabine König, Olexandr Dybkov, Henning Urlaub, Christof Lenz, Ralph H Kehlenbach
ELYS is a nucleoporin that localizes to the nuclear side of the nuclear pore complex (NPC) in interphase cells. In mitosis, it serves as an assembly platform that interacts with chromatin and then with nucleoporin subcomplexes to initiate post-mitotic NPC assembly. Here we identify ELYS as a major binding partner of the membrane protein VAPB during mitosis. In mitosis, ELYS becomes phosphorylated at many sites, including a predicted FFAT (two phenylalanines in an acidic tract) motif, which mediates interaction with the MSP (major sperm protein)-domain of VAPB...
April 11, 2024: EMBO Reports
#17
JOURNAL ARTICLE
Vaibhav Sahai, Michael Rothe, Pam K Mangat, Elizabeth Garrett-Mayer, Vijay Suhag, Elie G Dib, Inderjit Mehmi, Kunal C Kadakia, Evan Pisick, Herbert L Duvivier, Phat Le, Rui Li, David P Michelin, Ryan E Wilcox, Gina N Grantham, Dominique C Hinshaw, Abigail Gregory, Susan Halabi, Richard L Schilsky
PURPOSE: Targeted Agent and Profiling Utilization Registry is a phase II basket trial evaluating the antitumor activity of commercially available targeted agents in patients with advanced cancer with genomic alterations known to be drug targets. Results of a cohort of patients with solid tumors with BRAF alterations treated with regorafenib are reported. METHODS: Eligible patients had measurable disease (RECIST v.1.1), Eastern Cooperative Oncology Group performance status 0-1, adequate organ function, and no standard treatment options...
April 2024: JCO Precision Oncology
#18
JOURNAL ARTICLE
Olaf Mercier, Frédéric Kolb, Elie Fadel
No abstract text is available yet for this article.
April 11, 2024: European Journal of Cardio-thoracic Surgery
#19
JOURNAL ARTICLE
Maximiliano Klug, Chad D Strange, Mylene T Truong, Zehavit Kirshenboim, Efrat Ofek, Eli Konen, Edith Michelle Marom
Thymic imaging is challenging because the imaging appearance of a variety of benign and malignant thymic conditions are similar. CT is the most commonly used modality for mediastinal imaging, while MRI and fluorine 18 fluorodeoxyglucose (FDG) PET/CT are helpful when they are tailored to the correct indication. Each of these imaging modalities has limitations and technical pitfalls that may lead to an incorrect diagnosis and mismanagement. CT may not be sufficient for the characterization of cystic thymic processes and differentiation between thymic hyperplasia and thymic tumors...
May 2024: Radiographics: a Review Publication of the Radiological Society of North America, Inc
#20
JOURNAL ARTICLE
Ophir Freund, Ariel Melloul, Sabrina Fried, Eyal Kleinhendler, Avraham Unterman, Evgeni Gershman, Avishay Elis, Amir Bar-Shai
Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a common cause for emergency department (ED) visits. Still, large scale studies that assess the management of AECOPD in the ED are limited. Our aim was to evaluate treatment characteristics of AE-COPD in the ED on a national scale. A prospective study as part of the COPD Israeli survey, conducted between 2017 and 2019, in 13 medical centers. Patients hospitalized with AECOPD were included and interviewed. Clinical data related to their ED and hospital stay were collected...
April 11, 2024: Internal and Emergency Medicine
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