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https://www.readbyqxmd.com/read/29351487/contribution-of-parasympathetic-muscarinic-augmentation-of-insulin-secretion-to-olanzapine-induced-hyperinsulinemia
#1
Michael R Rickels, Elys M Perez, Amy J Peleckis, Erica Alshehabi, Huong-Lan Nguyen, Darko Stefanovski, Karl Rickels, Karen L Teff
Atypical antipsychotic drugs have been associated with the development of obesity and diabetes. In particular, olanzapine can induce peripheral insulin resistance and compensatory hyperinsulinemia independent of weight gain or psychiatric disease. To determine if this compensatory increase in insulin is mediated by parasympathetic muscarinic stimulation, we randomized fifteen healthy subjects 2:1 to receive double-blind olanzapine or placebo for 9 days under diet and activity controlled inpatient conditions...
December 19, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29350950/local-melting-attracts-grain-boundaries-in-colloidal-polycrystals
#2
Caitlin E Cash, Jeremy Wang, Maya M Martirossyan, B Kemper Ludlow, Alejandro E Baptista, Nina M Brown, Eli J Weissler, Jatin Abacousnac, Sharon J Gerbode
We find that laser-induced local melting attracts and deforms grain boundaries in 2D colloidal crystals. When a melted region in contact with the edge of a crystal grain recrystallizes, it deforms the grain boundary-this attraction is driven by the multiplicity of deformed grain boundary configurations. Furthermore, the attraction provides a method to fabricate artificial colloidal crystal grains of arbitrary shape, enabling new experimental studies of grain boundary dynamics and ultimately hinting at a novel approach for fabricating materials with designer microstructures...
January 5, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29349211/who-votes-for-public-health-u-s-senator-characteristics-associated-with-voting-in-concordance-with-public-health-policy-recommendations-1998-2013
#3
Jonathan Purtle, Neal D Goldstein, Eli Edson, Annamarie Hand
Background: The voting behaviors of elected officials shape the public's health. Little is known, however, about the characteristics of elected officials who vote in concordance with public health policy recommendations. This article presents the results of study conducted with the aims of: 1) testing the hypothesis that US Democrat Senators vote in concordance with American Public Health Association (APHA) policy recommendations more frequently than US Republican Senators, 2) identifying US Senator characteristics independently associated with voting in concordance with APHA, and 3) assessing trends in APHA voting concordance by political party...
December 2017: SSM—Population Health
https://www.readbyqxmd.com/read/29347987/determinants-of-long-term-outcome-in-icu-survivors-results-from-the-frog-icu-study
#4
Etienne Gayat, Alain Cariou, Nicolas Deye, Antoine Vieillard-Baron, Samir Jaber, Charles Damoisel, Qin Lu, Xavier Monnet, Isabelle Rennuit, Elie Azoulay, Marc Léone, Heikel Oueslati, Bertrand Guidet, Diane Friedman, Antoine Tesnière, Romain Sonneville, Philippe Montravers, Sébastien Pili-Floury, Jean-Yves Lefrant, Jacques Duranteau, Pierre-François Laterre, Nicolas Brechot, Karine Chevreul, Morgane Michel, Bernard Cholley, Matthieu Legrand, Jean-Marie Launay, Eric Vicaut, Mervyn Singer, Matthieu Resche-Rigon, Alexandre Mebazaa
BACKGROUND: Intensive care unit (ICU) survivors have reduced long-term survival compared to the general population. Identifying parameters at ICU discharge that are associated with poor long-term outcomes may prove useful in targeting an at-risk population. The main objective of the study was to identify clinical and biological determinants of death in the year following ICU discharge. METHODS: FROG-ICU was a prospective, observational, multicenter cohort study of ICU survivors followed 1 year after discharge, including 21 medical, surgical or mixed ICUs in France and Belgium...
January 18, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29347404/scale-invariant-green-kubo-relation-for-time-averaged-diffusivity
#5
Philipp Meyer, Eli Barkai, Holger Kantz
In recent years it was shown both theoretically and experimentally that in certain systems exhibiting anomalous diffusion the time- and ensemble-averaged mean-squared displacement are remarkably different. The ensemble-averaged diffusivity is obtained from a scaling Green-Kubo relation, which connects the scale-invariant nonstationary velocity correlation function with the transport coefficient. Here we obtain the relation between time-averaged diffusivity, usually recorded in single-particle tracking experiments, and the underlying scale-invariant velocity correlation function...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347086/aggregation-fragmentation-diffusion-model-for-trail-dynamics
#6
Kyle Kawagoe, Greg Huber, Marc Pradas, Michael Wilkinson, Alain Pumir, Eli Ben-Naim
We investigate statistical properties of trails formed by a random process incorporating aggregation, fragmentation, and diffusion. In this stochastic process, which takes place in one spatial dimension, two neighboring trails may combine to form a larger one, and also one trail may split into two. In addition, trails move diffusively. The model is defined by two parameters which quantify the fragmentation rate and the fragment size. In the long-time limit, the system reaches a steady state, and our focus is the limiting distribution of trail weights...
July 2017: Physical Review. E
https://www.readbyqxmd.com/read/29345397/characteristics-of-patients-who-progress-from-bridging-to-long-term-oxygen-therapy
#7
Kovi Levin, Brigitte Borg, Belinda Miller, Kirk Kee, Eli Dabscheck
BACKGROUND AND OBJECTIVE: Patients with persistent hypoxia following an acute hospital admission may be discharged with "bridging" domiciliary oxygen as per criteria defined by the Thoracic Society of Australia and New Zealand. The need for continuous Long-Term Oxygen Therapy (LTOT) is then reassessed at a clinic review 1-2 months later. The aim of this study is to describe the characteristics of patients discharged from an acute hospital admission with continuous Short Term Oxygen Therapy (STOT), and subsequently to investigate for differences between subjects who proceeded to qualify for continuous LTOT versus those who were able to cease STOT at review...
January 18, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29344696/reconstruction-of-the-medial-patellotibial-ligament-results-in-favorable-clinical-outcomes-a-systematic-review
#8
Charles A Baumann, Eli L Pratte, Seth L Sherman, Elizabeth A Arendt, Betina B Hinckel
PURPOSE: The medial patellotibial ligament (MPTL), the medial patellofemoral ligament (MPFL), and the medial patellomeniscal ligament (MPML) support the stability of the patellofemoral joint. The purpose of this systematic review was to report the surgical techniques and clinical outcomes of the repair or reconstruction of the MPTL in isolation or concomitant with the MPFL and/or other procedures. METHODS: A systematic review of the literature was conducted. Inclusion criteria were articles in the English language that reported clinical outcomes of the reconstruction of the MPTL in isolation or in combination with the MPFL and/or other procedures...
January 17, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29343839/musical-auditory-stimulus-acutely-influences-heart-rate-dynamic-responses-to-medication-in-subjects-with-well-controlled-hypertension
#9
Eli Carlos Martiniano, Milana Drumond Ramos Santana, Érico Luiz Damasceno Barros, Maria do Socorro da Silva, David Matthew Garner, Luiz Carlos de Abreu, Vitor E Valenti
Music can improve the efficiency of medical treatment when correctly associated with drug action, reducing risk factors involving deteriorating cardiac function. We evaluated the effect of musical auditory stimulus associated with anti-hypertensive medication on heart rate (HR) autonomic control in hypertensive subjects. We evaluated 37 well-controlled hypertensive patients designated for anti-hypertensive medication. Heart rate variability (HRV) was calculated from the HR monitor recordings of two different, randomly sorted protocols (control and music) on two separate days...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343501/sequential-bmp7-tgf-%C3%AE-1-signaling-and-microbiota-instruct-mucosal-langerhans-cell-differentiation
#10
Tal Capucha, Noam Koren, Maria Nassar, Oded Heyman, Tsipora Nir, Maayan Levy, Gili Zilberman-Schapira, Katya Zelentova, Luba Eli-Berchoer, Martin Zenke, Thomas Hieronymus, Asaf Wilensky, Herve Bercovier, Eran Elinav, Björn E Clausen, Avi-Hai Hovav
Mucosal Langerhans cells (LCs) originate from pre-dendritic cells and monocytes. However, the mechanisms involved in their in situ development remain unclear. Here, we demonstrate that the differentiation of murine mucosal LCs is a two-step process. In the lamina propria, signaling via BMP7-ALK3 promotes translocation of LC precursors to the epithelium. Within the epithelium, TGF-β1 finalizes LC differentiation, and ALK5 is crucial to this process. Moreover, the local microbiota has a major impact on the development of mucosal LCs, whereas LCs in turn maintain mucosal homeostasis and prevent tissue destruction...
January 17, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29340991/neoadjuvant-chemotherapy-for-hypopharyngeal-squamous-cell-carcinoma-and-personalized-medicine-in-head-and-neck-cancer
#11
EDITORIAL
Eli Gordin
No abstract text is available yet for this article.
January 16, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29340781/suicidal-thoughts-and-behaviors-among-college-students-and-same-aged-peers-results-from-the-world-health-organization-world-mental-health-surveys
#12
Philippe Mortier, Randy P Auerbach, Jordi Alonso, William G Axinn, Pim Cuijpers, David D Ebert, Jennifer G Green, Irving Hwang, Ronald C Kessler, Howard Liu, Matthew K Nock, Stephanie Pinder-Amaker, Nancy A Sampson, Alan M Zaslavsky, Jibril Abdulmalik, Sergio Aguilar-Gaxiola, Ali Al-Hamzawi, Corina Benjet, Koen Demyttenaere, Silvia Florescu, Giovanni De Girolamo, Oye Gureje, Josep Maria Haro, Chiyi Hu, Yueqin Huang, Peter De Jonge, Elie G Karam, Andrzej Kiejna, Viviane Kovess-Masfety, Sing Lee, John J Mcgrath, Siobhan O'neill, Vladimir Nakov, Beth-Ellen Pennell, Marina Piazza, José Posada-Villa, Charlene Rapsey, Maria Carmen Viana, Miguel Xavier, Ronny Bruffaerts
PURPOSE: The primary aims are to (1) obtain representative prevalence estimates of suicidal thoughts and behaviors (STB) among college students worldwide and (2) investigate whether STB is related to matriculation to and attrition from college. METHODS: Data from the WHO World Mental Health Surveys were analyzed, which include face-to-face interviews with 5750 young adults aged 18-22 spanning 21 countries (weighted mean response rate = 71.4%). Standardized STB prevalence estimates were calculated for four well-defined groups of same-aged peers: college students, college attriters (i...
January 16, 2018: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29340648/a-novel-strategy-for-quantifying-choriocapillaris-flow-voids-using-swept-source-oct-angiography
#13
Qinqin Zhang, Fang Zheng, Elie H Motulsky, Giovanni Gregori, Zhongdi Chu, Chieh-Li Chen, Chunxia Li, Luis de Sisternes, Mary Durbin, Philip J Rosenfeld, Ruikang K Wang
Purpose: To achieve reproducible imaging of the choriocapillaris and associated flow voids using swept-source OCT angiography (SS-OCTA). Methods: Subjects were enrolled and SS-OCTA was performed using the 3 × 3 mm scan pattern. Blood flow was identified using the complex optical microangiography (OMAG) algorithm. The choriocapillaris was defined as a slab from the outer boundary of Bruch's membrane (BM) to approximately 20 μm below BM. Compensation for the shadowing effect caused by the RPE and BM complex on the choriocapillaris angiogram was achieved by using the structural information from the same slab...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29339979/brca1-and-brca2-mutation-spectrum-an-update-on-mutation-distribution-in-a-large-cancer-genetics-clinic-in-norway
#14
Cecilie Heramb, Teresia Wangensteen, Eli Marie Grindedal, Sarah Louise Ariansen, Sheba Lothe, Ketil Riddervold Heimdal, Lovise Mæhle
Background: Founder mutations in the two breast cancer genes, BRCA1 and BRCA2, have been described in many populations, among these are Ashkenazi-Jewish, Polish, Norwegian and Icelandic. Founder mutation testing in patients with relevant ancestry has been a cost-efficient approach in such populations. Four Norwegian BRCA1 founder mutations were defined by haplotyping in 2001, and accounted for 68% of BRCA1 mutation carriers at the time. After 15 more years of genetic testing, updated knowledge on the mutation spectrum of both BRCA1 and BRCA2 in Norway is needed...
2018: Hereditary Cancer in Clinical Practice
https://www.readbyqxmd.com/read/29339687/subclinical-left-ventricular-systolic-dysfunction-in-patients-with-severe-aortic-stenosis-a-speckle-tracking-echocardiography-study
#15
Betül Cengiz, Şükrü Taylan Şahin, Selen Yurdakul, Serkan Kahraman, Ayşen Bozkurt, Saide Aytekin
OBJECTIVE: In patients with aortic stenosis (AS), the left ventricular (LV) geometry changes due to the increased LV afterload. However, subclinical myocardial dysfunction can develop despite a normal LV ejection fraction (EF). This study was an investigation of subclinical LV systolic dysfunction in patients with severe AS with a normal LV EF using a strain imaging method, speckle-tracking echocardiography (STE), and an evaluation of its correlation with novel indices to assess the severity of AS...
January 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29339509/biodegradable-piezoelectric-force-sensor
#16
Eli J Curry, Kai Ke, Meysam T Chorsi, Kinga S Wrobel, Albert N Miller, Avi Patel, Insoo Kim, Jianlin Feng, Lixia Yue, Qian Wu, Chia-Ling Kuo, Kevin W-H Lo, Cato T Laurencin, Horea Ilies, Prashant K Purohit, Thanh D Nguyen
Measuring vital physiological pressures is important for monitoring health status, preventing the buildup of dangerous internal forces in impaired organs, and enabling novel approaches of using mechanical stimulation for tissue regeneration. Pressure sensors are often required to be implanted and directly integrated with native soft biological systems. Therefore, the devices should be flexible and at the same time biodegradable to avoid invasive removal surgery that can damage directly interfaced tissues. Despite recent achievements in degradable electronic devices, there is still a tremendous need to develop a force sensor which only relies on safe medical materials and requires no complex fabrication process to provide accurate information on important biophysiological forces...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29337810/the-authors-reply
#17
Hervé Dupont, Yazine Mahjoub, Taieb Chouaki, Emmanuel Lorne, Elie Zogheib
No abstract text is available yet for this article.
February 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29336453/semimetallic-carbon-honeycombs-new-three-dimensional-graphene-allotropes-with-dirac-cones
#18
Shuaiwei Wang, Donghai Wu, Baocheng Yang, Eli Ruckenstein, Houyang Chen
Classic two-dimensional (2D) graphene possesses outstanding properties due to Dirac cone structures. When scaling up to three-dimensional (3D) structures, their high porosity and large surface-area-to-volume ratio made them have more promising engineering perspectives. However, the currently synthesized and density-functional-theory-predicted 3D graphene structures, termed as carbon honeycombs (CHCs), are metallic. Herein, we propose new families of stable semimetallic CHC structures, which have lower energies than the previous experimentally reported structure and they would be realized experimentally...
January 16, 2018: Nanoscale
https://www.readbyqxmd.com/read/29335911/biotechnology-software-in-the-digital-age-are-you-winning
#19
Cornelia Johanna Franziska Scheitz, Lawrence J Peck, Eli S Groban
There is a digital revolution taking place and biotechnology companies are slow to adapt. Many pharmaceutical, biotechnology, and industrial bio-production companies believe that software must be developed and maintained in-house and that data are more secure on internal servers than on the cloud. In fact, most companies in this space continue to employ large IT and software teams and acquire computational infrastructure in the form of in-house servers. This is due to a fear of the cloud not sufficiently protecting in-house resources and the belief that their software is valuable IP...
January 16, 2018: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29334490/differential-impact-of-local-and-regional-aortic-stiffness-on-left-ventricular-remodeling-a-cardiovascular-magnetic-resonance-study
#20
Thiago Quinaglia, Mourad Z Bensalah, Emilie Bollache, Nadjia Kachenoura, Gilles Soulat, Pierre Boutouyrie, Stéphane Laurent, Elie Mousseaux
BACKGROUND: Left ventricular (LV) remodeling and aortic stiffness have independent predictive value for all causes and cardiovascular mortality. Because elastic properties of the arterial wall vary along the aortic pathway, we hypothesized that local and regional aortic stiffness could differently impact on LV remodeling. METHODS AND RESULTS: Regional aortic stiffness was determined from carotid-femoral pulse wave velocity (cfPWV) measured by aplanation tonometry...
January 13, 2018: Journal of Hypertension
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