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https://www.readbyqxmd.com/read/29148332/medicare-advantage-and-traditional-medicare-hospitalization-intensity-and-readmissions
#1
Rachel Mosher Henke, Zeynal Karaca, Teresa B Gibson, Eli Cutler, Marguerite L Barrett, Katharine Levit, Jayne Johann, Lauren Hersch Nicholas, Herbert S Wong
Medicare Advantage plans have incentives and tools to optimize patient care. Therefore, Medicare Advantage hospitalizations may have lower cost and higher quality than similar traditional Medicare hospitalizations. We applied a coarsened matching approach to 2013 Healthcare Cost and Utilization Project hospital discharge data from 22 states to compare hospital cost, length of stay, and readmissions for Traditional Medicare and Medicare Advantage. We found that Medicare Advantage hospitalizations were substantially less expensive and shorter for mental health stays but costlier and longer for injury and surgical stays...
March 1, 2017: Medical Care Research and Review: MCRR
https://www.readbyqxmd.com/read/29146853/genome-sequences-of-four-subcluster-l2-mycobacterium-phages-finemlucis-miley16-wilder-and-zakai
#2
Christopher D Herren, Alexandra Peister, Timothy S Breton, Maggie S Hill, Marcy S Anderson, Adeline W Chang, Sydney B Klein, Mackenzie M Thornton, Stacy J Vars, Kasey E Wagner, Paige L Wiebe, Thomas G Williams, Coraima P Yanez, Jasanta M Ackles, Darius Artis, Ryan J Brazier, Ronald J Bryant, Kerel O Callwood, Isaiah H Carter, Cameron L DeBose, Christian D Edwards, Isaiah C Ezemba, Renshal R Joaquin, Zakai M Meghoo-Peddie, Ziha G Meghoo-Peddie, Ryan W Moore, Christopher E Smith, Adam J Turner, Raymond L Vorters, Jeffrey J Wider, Liesel L Krout, Mia S Comis, Madison J Davick, Eli E Michaud, Bailey E Shevenell, Sarah E Stanley, Chelsey I Frank, Jacob R Montgomery, Lawrence S Blumer, Jean A Doty, Martha Smith-Caldas, Welkin H Pope, Steven G Cresawn, Daniel A Russell, Rebecca A Garlena, Deborah Jacobs-Sera, Graham F Hatfull
Four subcluster L2 mycobacteriophages, Finemlucis, Miley16, Wilder, and Zakai, that infect Mycobacterium smegmatis mc(2)155 were isolated. The four phages are closely related to each other and code for 12 to 14 tRNAs and 130 to 132 putative protein-coding genes, including tyrosine integrases, cro, immunity repressors, and excise genes involved in the establishment of lysogeny.
November 16, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29145084/low-voltage-electric-potential-as-a-driving-force-to-hinder-biofouling-in-self-supporting-carbon-nanotube-membranes
#3
Chidambaram Thamaraiselvan, Avner Ronen, Sofia Lerman, Moran Balaish, Yair Ein-Eli, Carlos G Dosoretz
This study aimed at evaluating the contribution of low voltage electric field, both alternating (AC) and direct (DC) currents, on the prevention of bacterial attachment and cell inactivation to highly electrically conductive self-supporting carbon nanotubes (CNT) membranes at conditions which encourage biofilm formation. A mutant strain of Pseudomonas putida S12 was used a model bacterium and either capacitive or resistive electrical circuits and two flow regimes, flow-through and cross-flow filtration, were studied...
November 3, 2017: Water Research
https://www.readbyqxmd.com/read/29143821/erratum-the-neuropeptide-nmu-amplifies-ilc2-driven-allergic-lung-inflammation
#4
Antonia Wallrapp, Samantha J Riesenfeld, Patrick R Burkett, Raja-Elie E Abdulnour, Jackson Nyman, Danielle Dionne, Matan Hofree, Michael S Cuoco, Christopher Rodman, Daneyal Farouq, Brian J Haas, Timothy L Tickle, John J Trombetta, Pankaj Baral, Christoph S N Klose, Tanel Mahlakõiv, David Artis, Orit Rozenblatt-Rosen, Isaac M Chiu, Bruce D Levy, Monika S Kowalczyk, Aviv Regev, Vijay K Kuchroo
This corrects the article DOI: 10.1038/nature24029.
November 15, 2017: Nature
https://www.readbyqxmd.com/read/29141964/acute-decompensated-pulmonary-hypertension
#5
Laurent Savale, Jason Weatherald, Xavier Jaïs, Constance Vuillard, Athénaïs Boucly, Mitja Jevnikar, David Montani, Olaf Mercier, Gerald Simonneau, Elie Fadel, Olivier Sitbon, Marc Humbert
Acute right heart failure in chronic precapillary pulmonary hypertension is characterised by a rapidly progressive syndrome with systemic congestion resulting from impaired right ventricular filling and/or reduced right ventricular flow output. This clinical picture results from an imbalance between the afterload imposed on the right ventricle and its adaptation capacity. Acute decompensated pulmonary hypertension is associated with a very poor prognosis in the short term. Despite its major impact on survival, its optimal management remains very challenging for specialised centres, without specific recommendations...
December 31, 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29138392/bay-region-functionalisation-of-ar-bian-ligands-and-their-use-within-highly-absorptive-cationic-iridium-iii-dyes
#6
Kamrul Hasan, Jingyi Wang, Amlan K Pal, Claus Hierlinger, Véronique Guerchais, Han Sen Soo, Felipe García, Eli Zysman-Colman
We report the synthesis, UV-vis absorption, electrochemical characterisation, and DFT studies of five panchromatic, heteroleptic iridium complexes (four of which are new) supported by Ar-BIAN ligands. In particular, the synthesis of an ester-functionalised Ar-BIAN ligand was carried out by a mechanochemical milling approach, which was advantageous over conventional metal templating solution methods in terms of reaction time and product purity. The introduction of ester and carboxylate functionalities at the bay region of the acenaphthene motif increases each ligand's π-accepting capacity and imparts grafting capabilities to the iridium complexes...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29137218/importance-of-fish-genetics-in-light-chain-amyloidosis
#7
EDITORIAL
Morie A Gertz, Angela Dispenzieri, Eli Muchtar
No abstract text is available yet for this article.
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29134868/-you-ve-changed-low-self-concept-clarity-predicts-lack-of-support-for-partner-change
#8
Lydia F Emery, Wendi L Gardner, Eli J Finkel, Kathleen L Carswell
People often pursue self-change, and having a romantic partner who supports these changes increases relationship satisfaction. However, most existing research focuses only on the experience of the person who is changing. What predicts whether people support their partner's change? People with low self-concept clarity resist self-change, so we hypothesized that they would be unsupportive of their partner's changes. People with low self-concept clarity did not support their partner's change (Study 1a), because they thought they would have to change, too (Study 1b)...
November 1, 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/29134607/the-cost-effectiveness-of-dulaglutide-1-5mg-versus-exenatide-qw-for-the-treatment-of-patients-with-type-2-diabetes-mellitus-in-france
#9
Mickael Basson, Dionysios Ntais, Ruba Ayyub, Donna Wright, Julia Lowin, Florence Chartier, Stéphane Roze, Kirsi Norrbacka
INTRODUCTION: Dulaglutide is a novel onceweekly administered glucagon-like peptide 1 receptor agonist (GLP-1 RA) for the management of type 2 diabetes mellitus (T2DM). The objective of this analysis was to estimate the cost-effectiveness of dulaglutide 1.5 mg versus exenatide QW for the management of T2DM in France. METHODS: The QuintilesIMS CORE Diabetes Model was used to estimate the expected lifetime direct medical costs and outcomes of T2DM from the perspective of the French National Health Service...
November 13, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29134193/snowball-earth-climate-dynamics-and-cryogenian-geology-geobiology
#10
Paul F Hoffman, Dorian S Abbot, Yosef Ashkenazy, Douglas I Benn, Jochen J Brocks, Phoebe A Cohen, Grant M Cox, Jessica R Creveling, Yannick Donnadieu, Douglas H Erwin, Ian J Fairchild, David Ferreira, Jason C Goodman, Galen P Halverson, Malte F Jansen, Guillaume Le Hir, Gordon D Love, Francis A Macdonald, Adam C Maloof, Camille A Partin, Gilles Ramstein, Brian E J Rose, Catherine V Rose, Peter M Sadler, Eli Tziperman, Aiko Voigt, Stephen G Warren
Geological evidence indicates that grounded ice sheets reached sea level at all latitudes during two long-lived Cryogenian (58 and ≥5 My) glaciations. Combined uranium-lead and rhenium-osmium dating suggests that the older (Sturtian) glacial onset and both terminations were globally synchronous. Geochemical data imply that CO2 was 10(2) PAL (present atmospheric level) at the younger termination, consistent with a global ice cover. Sturtian glaciation followed breakup of a tropical supercontinent, and its onset coincided with the equatorial emplacement of a large igneous province...
November 2017: Science Advances
https://www.readbyqxmd.com/read/29133608/systemic-vasculitis-with-dermatomyositis-hearing-loss-neuropathy-and-multiorgan-dysfunction
#11
Priya S Dhawan, P James B Dyck, Jennifer A Tracy, Elie Naddaf
No abstract text is available yet for this article.
November 14, 2017: Neurology
https://www.readbyqxmd.com/read/29132436/towards-fair-and-effective-north-south-collaboration-realising-a-programme-for-demand-driven-and-locally-led-research
#12
Maarten Olivier Kok, John Owusu Gyapong, Ivan Wolffers, David Ofori-Adjei, Elis Joost Ruitenberg
BACKGROUND: At the turn of the 90s, studies showed that health research contributed little to health and development in low- and middle-income countries because it was oriented towards international priorities and dominated by researchers from the North. A new approach to North-South collaboration was required that would support demand-driven and locally led research in the South. The aim of this study was to analyse the development and functioning of a programme for demand-driven and locally led research in Ghana that was supported by a North-South collaboration...
November 13, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/29132309/significant-differences-in-terms-of-codon-usage-bias-between-bacteriophage-early-and-late-genes-a-comparative-genomics-analysis
#13
Oriah Mioduser, Eli Goz, Tamir Tuller
BACKGROUND: Viruses undergo extensive evolutionary selection for efficient replication which effects, among others, their codon distribution. In the current study, we aimed at understanding the way evolution shapes the codon distribution in early vs. late viral genes in terms of their expression during different stages in the viral replication cycle. To this end we analyzed 14 bacteriophages and 11 human viruses with available information about the expression phases of their genes. RESULTS: We demonstrated evidence of selection for distinct composition of synonymous codons in early and late viral genes in 50% of the analyzed bacteriophages...
November 13, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29131846/how-many-species-and-under-what-names-using-dna-barcoding-and-genbank-data-for-west-central-african-amphibian-conservation
#14
Jessica L Deichmann, Daniel G Mulcahy, Hadrien Vanthomme, Elie Tobi, Addison H Wynn, Breda M Zimkus, Roy W McDiarmid
Development projects in west Central Africa are proceeding at an unprecedented rate, often with little concern for their effects on biodiversity. In an attempt to better understand potential impacts of a road development project on the anuran amphibian community, we conducted a biodiversity assessment employing multiple methodologies (visual encounter transects, auditory surveys, leaf litter plots and pitfall traps) to inventory species prior to construction of a new road within the buffer zone of Moukalaba-Doudou National Park, Gabon...
2017: PloS One
https://www.readbyqxmd.com/read/29129177/copd-x-australian-and-new-zealand-guidelines-for-the-diagnosis-and-management-of-chronic-obstructive-pulmonary-disease-2017-update
#15
Ian A Yang, Juliet L Brown, Johnson George, Sue Jenkins, Christine F McDonald, Vanessa M McDonald, Kirsten Phillips, Brian J Smith, Nicholas A Zwar, Eli Dabscheck
Chronic obstructive pulmonary disease (COPD) is characterised by persistent respiratory symptoms and chronic airflow limitation, and is associated with exacerbations and comorbidities. Advances in the management of COPD are updated quarterly in the national COPD guidelines, the COPD-X plan, published by Lung Foundation Australia in conjunction with the Thoracic Society of Australia and New Zealand and available at http://copdx.org.au. Main recommendations: Spirometry detects persistent airflow limitation (post-bronchodilator FEV1/FVC < 0...
November 20, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/29128965/abemaciclib-first-global-approval
#16
Esther S Kim
Abemaciclib (Verzenio™) is an orally administered inhibitor of cyclin-dependent kinases 4 and 6 that is being developed by Eli Lilly and Company. Abemaciclib has been approved in the USA for the treatment of hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer, in combination with fulvestrant in women with disease progression following endocrine therapy, and as monotherapy in adult patients with disease progression following endocrine therapy and prior chemotherapy in the metastatic setting...
November 11, 2017: Drugs
https://www.readbyqxmd.com/read/29128430/-a-reporting-tool-for-practice-guidelines-in-health-care-the-right-statement
#17
Yaolong Chen, Kehu Yang, Ana Marušić, Amir Qaseem, Joerg J Meerpohl, Signe Flottorp, Elie A Akl, Holger J Schünemann, Edwin S Y Chan, Yngve Falck-Ytter, Faruque Ahmed, Sarah Barber, Chiehfeng Chen, Mingming Zhang, Bin Xu, Jinhui Tian, Fujian Song, Hongcai Shang, Kun Tang, Qi Wang, Susan L Norris, Valérie C Labonté, Ralph Möhler, Ina Kopp, Monika Nothacker, Joerg J Meerpohl
The quality of reporting practice guidelines is often poor, and there is no widely accepted guidance or standards for such reporting in health care. The international RIGHT (Reporting Items for practice Guidelines in HealThcare) Working Group was established to address this gap. The group followed an existing framework for developing guidelines for health research reporting and the EQUATOR (Enhancing the QUAlity and Transparency Of health Research) Network approach. It developed a checklist and an explanation and elaboration statement...
November 9, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/29128335/hereditary-angioedema-with-normal-c1-inhibitor-and-f12-mutations-in-42-brazilian-families
#18
Camila Lopes Veronez, Adriana S Moreno, Rosemeire Navickas Constantino-Silva, Luana S M Maia, Mariana P L Ferriani, Fábio F M Castro, Solange Rodrigues Valle, Victor Koji Nakamura, Nathália Cagini, Rozana Fátima Gonçalves, Eli Mansour, Faradiba Sarquis Serpa, Gabriela Andrade Coelho Dias, Miguel Alberto Piccirillo, Eliana Toledo, Marli de Souza Bernardes, Sven Cichon, Christiane Stieber, L Karla Arruda, João Bosco Pesquero, Anete Sevciovic Grumach
BACKGROUND: Hereditary angioedema (HAE) with normal C1 inhibitor (C1-INH) is a rare condition with clinical features similar to those of HAE with C1-INH deficiency. Mutations in the F12 gene have been identified in subsets of patients with HAE with normal C1-INH, mostly within families of European descent. OBJECTIVES: Our aim was to describe clinical characteristics observed in Brazilians from 42 families with HAE and F12 gene mutations (FXII-HAE), and to compare these findings with those from other populations...
November 8, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29126956/effect-of-graduated-compression-stockings-on-venous-lower-limb-hemodynamics-in-healthy-amateur-runners
#19
Oswaldo Teno Castilho Junior, Nei Rodrigues Alves Dezotti, Marcelo Bellini Dalio, Edwaldo Edner Joviliano, Carlos Eli Piccinato
OBJECTIVE: The objective of this study was to analyze the effect of graduated compression stockings (GCS) on venous lower limb hemodynamics in healthy amateur runners. METHODS: Ten runners were evaluated during rest and after a 10-km run without and with knee-high GCS of 20 to 30 mm Hg. Air plethysmography evaluated venous filling index (VFI), ejection fraction, and residual volume fraction (RVF) in both limbs. Capillary lactate level and heart rate were also measured...
November 7, 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29122003/docosahexaenoic-acid-mechanisms-of-action-on-the-bovine-oocyte-cumulus-complex
#20
Sebastien Elis, Mouhamad Oseikria, Anais Vitorino Carvalho, Priscila Silvana Bertevello, Emilie Corbin, Ana-Paula Teixeira-Gomes, Jérôme Lecardonnel, Catherine Archilla, Véronique Duranthon, Valérie Labas, Svetlana Uzbekova
BACKGROUND: Supplementation of bovine oocyte-cumulus complexes during in vitro maturation (IVM) with 1 μM of docosahexaenoic acid (DHA), C22:6 n-3 polyunsaturated fatty acid, was reported to improve in vitro embryo development. The objective of this paper was to decipher the mechanisms of DHA action. RESULTS: Transcriptomic analysis of 1 μM DHA-treated and control cumulus cells after 4 h IVM showed no significant difference in gene expression. MALDI-TOF mass spectrometry analysis of lipid profiles in DHA-treated and control oocytes and cumulus cells after IVM showed variations of only 3 out of 700 molecular species in oocytes and 7 out of 698 species in cumulus cells (p < 0...
November 9, 2017: Journal of Ovarian Research
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