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https://www.readbyqxmd.com/read/28819400/rapid-breast-cancer-disease-progression-following-cyclin-dependent-kinase-4-and-6-inhibitor-discontinuation
#1
Sami I Bashour, Iman Doostan, Khandan Keyomarsi, Vicente Valero, Naoto T Ueno, Powel H Brown, Jennifer K Litton, Kimberly B Koenig, Meghan Karuturi, Sausan Abouharb, Debasish Tripathy, Stacy L Moulder-Thompson, Nuhad K Ibrahim
Background: CDK 4 and 6 inhibitors (CDK4/6i), which arrest unregulated cancer cell proliferation, show clinical efficacy in breast cancer. Unexpectedly, a patient treated on a CDK4/6i-based trial, as first-line therapy in metastatic breast cancer, developed rapid disease progression following discontinuation of study drug while receiving standard second-line therapy off trial. We thus sought to expand this observation within a population of patients treated similarly at The University of Texas MD Anderson Cancer Center...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28817100/modulatory-effects-of-exogenously-applied-polyamines-on-postharvest-physiology-antioxidant-system-and-shelf-life-of-fruits-a-review
#2
REVIEW
Sunil Sharma, Sunil Pareek, Narashans Alok Sagar, Daniel Valero, Maria Serrano
Polyamines (PAs) are natural compounds involved in many growth and developmental processes in plants, and, specifically in fruits, play a vital role regulating its development, ripening and senescence processes. Putrescine (PUT), spermine (SPE), and spermidine (SPD) are prominent PAs applied exogenously to extend shelf life of fruits. They also originate endogenously during developmental phases of horticultural crops and simultaneously affect the quality attributes and shelf life. Their anti-ethylene nature is being exploited to enhance the shelf life when exogenously applied on fruits...
August 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28816578/cost-analysis-of-telerehabilitation-after-arthroscopic-subacromial-decompression
#3
Jose Manuel Pastora-Bernal, Rocío Martín-Valero, Francisco Javier Barón-López
Background Subacromial impingement syndrome poses a substantial socioeconomic burden, leading to significant consumption of healthcare. Health systems are calling for greater evidence of economic impacts of particular healthcare services. Telerehabilitation programmes have the potential to reduce costs and improve patient access as an alternative to traditional care. Cost analysis has been traditionally included in study protocols and results, although the reliability and research methodology have frequently been under debate...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/28815510/inhibition-of-%C3%AE-secretase-leads-to-an-increase-in-presenilin-1
#4
Aitana Sogorb-Esteve, María-Salud García-Ayllón, Marta Llansola, Vicente Felipo, Kaj Blennow, Javier Sáez-Valero
γ-Secretase inhibitors (GSIs) are potential therapeutic agents for Alzheimer's disease (AD); however, trials have proven disappointing. We addressed the possibility that γ-secretase inhibition can provoke a rebound effect, elevating the levels of the catalytic γ-secretase subunit, presenilin-1 (PS1). Acute treatment of SH-SY5Y cells with the GSI LY-374973 (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester, DAPT) augments PS1, in parallel with increases in other γ-secretase subunits nicastrin, presenilin enhancer 2, and anterior pharynx-defective 1, yet with no increase in messenger RNA expression...
August 16, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28766055/non-synonymous-wnt16-polymorphisms-alleles-are-associated-with-different-osteoarthritis-phenotypes
#5
Carmen García-Ibarbia, Sara Neila, Carlos Garcés, Maria A Alonso, María T Zarrabeitia, Carmen Valero, Fernando Ortiz, José A Riancho
Hereditary factors have a strong influence on osteoarthritis (OA). The Wnt pathway is involved in bone and cartilage homeostasis. Hence, we hypothesized that allelic variations of WNT16 could influence the OA phenotype. We studied 509 Caucasian patients undergoing joint replacement due to severe primary OA. Radiographs were used to classify the OA as atrophic or hypertrophic. Two nonsynonymous polymorphisms of WNT16 (rs2707466 and rs2908004) were analyzed. The association between the genotypes and the OA phenotype was analyzed by logistic regression and adjusted for age and body mass index...
August 1, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28757257/assessment-of-dually-labelled-pegylated-liposomes-transplacental-passage-and-placental-penetration-using-a-combination-of-two-ex-vivo-human-models-the-dually-perfused-placenta-and-the-suspended-villous-explants
#6
Lucie Valero, Khair Alhareth, Sophie Gil, Christelle Simasotchi, Caroline Roques, Daniel Scherman, Nathalie Mignet, Thierry Fournier, Karine Andrieux
Uptake and passage of nanocarriers through the placenta are critical information to develop new therapeutic approaches during pregnancy. In order to assess nanocarriers transplacental passage and penetration into the placenta, we studied and optimized two ex-vivo human models: the dually perfused placenta and the placenta explants. Doubly labelled PEGylated liposomes were used as models to provide data on the penetration and transplacental passage of drugs and liposomes. A HPLC method was set-up to quantify both carboxyfluorescein and lipid-rhodamine...
July 27, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28751618/mitochondria-sustain-store-operated-currents-in-colon-cancer-cells-but-not-in-normal-colonic-cells-reversal-by-non-steroidal-anti-inflammatory-drugs
#7
Miriam Hernández-Morales, Diego Sobradillo, Ruth A Valero, Eva Muñoz, Daniel Ubierna, Mary P Moyer, Lucía Núñez, Carlos Villalobos
Tumor cells undergo a critical remodeling of intracellular Ca2+ homeostasis that contribute to important cancer hallmarks. Store-operated Ca2+ entry (SOCE), a Ca2+ entry pathway modulated by mitochondria, is dramatically enhanced in colon cancer cells. In addition, most cancer cells display the Warburg effect, a metabolic switch from mitochondrial metabolism to glycolysis that provides survival advantages. Accordingly, we investigated mitochondria control of store-operated currents (SOCs) in two cell lines previously selected for representing human normal colonic cells and colon cancer cells...
July 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28736021/infectious-complications-and-multidrug-resistant-bacteria-in-patients-with-hematopoietic-stem-cell-transplantation-in-the-first-12-months-after-transplant
#8
A César-Arce, P Volkow-Fernández, L M Valero-Saldaña, B Acosta-Maldonado, D Vilar-Compte, P Cornejo-Juárez
BACKGROUND: Hematopoietic stem cell transplantation (HSCT) has been used as treatment in different hematologic and solid malignancies. The aim of this study was to describe the frequency of infectious complications, microbiology, and outcome in patients undergoing HSCT in Mexico during the pre-engraftment period and the impact on mortality rates at 12 months. METHODS: We conducted a retrospective study of all hematologic malignancies that received HSCT from January 2009 and December 2014, at an oncology reference center...
July 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28735722/-is-the-introduction-of-clinical-management-programs-for-patients-with-chronic-obstructive-pulmonary-disease-useful-comparison-of-the-effectiveness-of-two-interventions-on-the-clinical-progress-and-care-received
#9
Ingrid Solanes, Ignasi Bolíbar, Maria Antònia Llauger, Meritxell Peiro, Pepi Valverde, Mar Fraga, Casimira Medrano, Teresa Bigorra, Montserrat Freixas, Iskra Ligüerre, Maria Antònia Pou, Leandra Domínguez, Carles Valero, Judit Solà, Jordi Giner, Vicente Plaza
OBJECTIVE: To evaluate the effectiveness of two management programs on patients with chronic obstructive pulmonary disease (COPD). DESIGN: A study with a quasi-experimental design was used to evaluate the effectiveness of two interventions (I1, I2) for the care of patients with COPD after a mean follow-up of 31.2months. SETTING: Primary Care Centres in two Barcelona Health Areas and their referral hospitals. PARTICIPANTS: Patients with COPD selected by simple random sampling using any disease code corresponding to COPD...
July 20, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28728796/-lifetime-psychiatric-disorders-a-comparision-study-between-offspring-of-parents-with-bipolar-disorder-type-i-versus-the-offspring-of-community-controls-parents
#10
Juan David Palacio-Ortiz, Cristian Esteban Peña-Quintero, María Alejandra Gómez-Valero, Paula Andrea Bustamante-Gómez, Pilar Helena Arroyave-Sierra, Cristian David Vargas-Upeguí, Carlos López-Jaramillo
INTRODUCTION: Literature reports show that Bipolar Offspring (BO) present with a wide range of psychiatric disorders. Comparison between BO and Control Parent Offspring (CPO) may help to identify which psychopathological findings are specific to this high-risk group. OBJECTIVE: To compare the psychopathological characteristics between a group of BO type-I and a group of CPO, by identifying the presence of psychiatric disorders according the DSM-IV-TR. METHODS: A descriptive-correlational, cross-sectional and comparative study was conducted with 127 offspring of parents with bipolar disorder type-I from the multimodal intervention program (PRISMA) and with 150 CPO between 6 and 30 years of age...
July 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/28720943/non-enzymatic-browning-due-to-storage-is-reduced-by-using-clarified-lemon-juice-as-acidifier-in-industrial-scale-production-of-canned-peach-halves
#11
Domingo Saura, Salud Vegara, Nuria Martí, Manuel Valero, José Laencina
Non-enzymatic browning (NEB) in canned peach halves in syrup during storage was investigated. Absorbance at 420 nm (A420), colorimetric parameters (CIELab, TCD and La/b), fructose, glucose and sucrose, total sugar, organic acids, ascorbic acid (AA), dehydroascorbic acid, and 2,3-diketogulonic acid were used to estimate the extent of NEB during 1 year of storage at 30 °C and the relationships between each of these parameters and A420 were established. The investigation was carried out to explore the possibility of replacing the E330 commonly used as acidifier by turbid or clarified lemon juice (TLJ or CLJ) to obtain a product having good nutrition with better retention of quality...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28719984/cytotoxic-and-immunomodulatory-potential-activity-of-physalis-peruviana-fruit-extracts-on-cervical-cancer-hela-and-fibroblast-l929-cells
#12
Helen Mier-Giraldo, Luis Eduardo Díaz-Barrera, Lucy Gabriela Delgado-Murcia, Manuel Fernando Valero-Valdivieso, Gabriela Cáez-Ramírez
It was purposed to evaluate the biological potential of ethanol and isopropanol crude extracts of ripe Physalis peruviana fruits. Cytotoxic and immunomodulatory effects of the expression of interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 (MCP-1) were evaluated on human cervical cancer (HeLa) and murine fibroblast (L929) cells. The composition was evaluated by high-performance liquid chromatography diode-array detection and high-performance liquid chromatography ultraviolet/visible detection...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/28712672/noise-induced-cochlear-synaptopathy-in-rhesus-monkeys-macaca-mulatta
#13
M D Valero, J A Burton, S N Hauser, T A Hackett, R Ramachandran, M C Liberman
Cochlear synaptopathy can result from various insults, including acoustic trauma, aging, ototoxicity, or chronic conductive hearing loss. For example, moderate noise exposure in mice can destroy up to ∼50% of synapses between auditory nerve fibers (ANFs) and inner hair cells (IHCs) without affecting outer hair cells (OHCs) or thresholds, because the synaptopathy occurs first in high-threshold ANFs. However, the fiber loss likely impairs temporal processing and hearing-in-noise, a classic complaint of those with sensorineural hearing loss...
July 8, 2017: Hearing Research
https://www.readbyqxmd.com/read/28712671/analysis-of-stereotactic-biopsies-performed-on-suspicious-calcifications-identified-within-24-months-after-completion-of-breast-conserving-surgery-and-radiation-therapy-for-early-breast-cancer-can-biopsy-be-obviated
#14
Rosalind P Candelaria, Palita Hansakul, Alastair M Thompson, Huong Le-Petross, Vicente Valero, Roland Bassett, Monica L Huang, Lumarie Santiago, Beatriz E Adrada
BACKGROUND: To determine the cancer yield of stereotactic biopsy of suspicious calcifications identified within 24 months after breast conservation therapy (BCT). METHODS: Retrospective review of stereotactic biopsies performed during 2009-2013 for suspicious calcifications in the ipsilateral breast of patients who completed BCT. RESULTS: 94/2773 (3.4%) had stereotactic biopsies for suspicious calcifications in the ipsilateral breast; 7/94 (7...
July 1, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28711520/exploring-substrate-specificities-of-a-recombinant-rhizopus-oryzae-lipase-in-biodiesel-synthesis
#15
Albert Canet, M Dolors Benaiges, Francisco Valero, Patrick Adlercreutz
The alcoholysis of triolein was used to explore the specific features of a recombinant Rhizopus oryzae lipase (rROL) for biodiesel synthesis. For this purpose, different acylglycerols were compared as substrates in lipase-catalysed transesterification. rROL was shown to exhibit a higher specificity towards 1-monoolein than triolein compared to other R. oryzae lipases, being more than 4-fold more specific; in contrast, rROL did not accept 2-monoolein as substrate, concluding that it is highly 1,3-positional specific...
July 12, 2017: New Biotechnology
https://www.readbyqxmd.com/read/28707031/silencing-of-p2x7r-by-rna-interference-in-the-hippocampus-can-attenuate-morphological-and-behavioral-impact-of-pilocarpine-induced-epilepsy
#16
Rebeca Padrão Amorim, Michelle Gasparetti Leão Araújo, Jorge Valero, Iscia Lopes-Cendes, Vinicius Davila Bitencourt Pascoal, João Oliveira Malva, Maria José da Silva Fernandes
Cell signaling mediated by P2X7 receptors (P2X7R) has been suggested to be involved in epileptogenesis, via modulation of intracellular calcium levels, excitotoxicity, activation of inflammatory cascades, and cell death, among other mechanisms. These processes have been described to be involved in pilocarpine-induced status epilepticus (SE) and contribute to hyperexcitability, resulting in spontaneous and recurrent seizures. Here, we aimed to investigate the role of P2X7R in epileptogenesis in vivo using RNA interference (RNAi) to inhibit the expression of this receptor...
July 13, 2017: Purinergic Signalling
https://www.readbyqxmd.com/read/28705809/the-oncogenic-role-of-the-spliced-somatostatin-receptor-sst5tmd4-variant-in-prostate-cancer
#17
Daniel Hormaechea-Agulla, Juan M Jiménez-Vacas, Enrique Gómez-Gómez, Fernando L López, Julia Carrasco-Valiente, José Valero-Rosa, María M Moreno, Rafael Sánchez-Sánchez, Rosa Ortega-Salas, Francisco Gracia-Navarro, Michael D Culler, Alejandro Ibáñez-Costa, Manuel D Gahete, María J Requena, Justo P Castaño, Raúl M Luque
sst5TMD4, a splice variant of the sst5 gene, is overexpressed and associated with aggressiveness in various endocrine-related tumors, but its presence, functional role, and mechanisms of actions in prostate cancer (PCa)-the most common cancer type in males-is completely unexplored. In this study, formalin-fixed, paraffin-embedded prostate pieces from patients with localized PCa, which included tumoral and nontumoral adjacent regions (n = 45), fresh biopsies from patients with high-risk PCa (n = 52), and healthy fresh prostates from cystoprostatectomies (n = 14) were examined...
July 13, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28697136/circulating-epithelial-cells-in-intraductal-papillary-mucinous-neoplasms-and-cystic-pancreatic-lesions
#18
Katherine E Poruk, Vicente Valero, Jin He, Nita Ahuja, John L Cameron, Matthew J Weiss, Anne Marie Lennon, Michael Goggins, Laura D Wood, Christopher L Wolfgang
OBJECTIVES: Circulating epithelial cells (CECs) are identified in the blood of patients with intraductal papillary mucinous neoplasms (IPMNs) despite the absence of malignancy. We assessed the blood of patients undergoing resection for IPMN or other benign pancreatic lesions for CECs. METHODS: Peripheral blood was collected from 26 patients prior to pancreatic resection and filtered by the ISET (Isolation by Size of Epithelial Tumor Cells) method. Circulating epithelial cells were identified with antibodies to cytokeratin and Pdx1 (pancreas and duodenal homeobox protein 1), a pancreas marker...
August 2017: Pancreas
https://www.readbyqxmd.com/read/28696578/does-education-modify-the-effect-of-ethnicity-in-the-expression-of-ideal-cardiovascular-health-the-baptist-health-south-florida-employee-study
#19
Oluseye Ogunmoroti, Ovie A Utuama, Erin D Michos, Javier Valero-Elizondo, Victor Okunrintemi, Ziyad Ben Taleb, Raed Bahelah, Sankalp Das, Maribeth Rouseff, Don Parris, Arthur Agatston, Theodore Feldman, Emir Veledar, Wasim Maziak, Khurram Nasir
BACKGROUND: Despite the progress made to decrease risk factors for cardiovascular diseases, disparities still exist. We examined how education and ethnicity interact to determine disparities in cardiovascular health (CVH) as defined by the American Heart Association. HYPOTHESIS: Education modifies the effect of ethnicity on CVH. METHODS: Individual CVH metrics (smoking, physical activity, body mass index, diet, total cholesterol, blood pressure, and blood glucose) were defined as ideal, intermediate, or poor...
July 11, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28693698/meta-analysis-of-family-based-selective-prevention-programs-for-drug-consumption-in-adolescence
#20
María Valero de Vicente, Lluís Ballester Brage, María C Orte Socías, Joan A Amer Fernández
BACKGROUND: Substance consumption (SC) begins in adolescence and has been linked to protection factors such as family relationships (FR) and positive parenting (PP). There are few studies concerning the effectiveness of prevention programs based on the family, even though assessing interventions is one of the objectives of preventive science. The aim of this study was to analyze the evidence on family-based selective prevention programs in relation to drug consumption in adolescents. METHODOLOGY: A meta-analysis of 9 studies with 102 measures grouped in three dimensions, FR, PP and SC, ranging between 2001 and 2015, was conducted...
August 2017: Psicothema
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