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https://www.readbyqxmd.com/read/29465744/baseline-factors-predicting-a-response-to-neoadjuvant-chemotherapy-with-implications-for-non-surgical-management-of-triple-negative-breast-cancer
#1
R F D van la Parra, A B Tadros, C M Checka, G M Rauch, A Lucci, B D Smith, S Krishnamurthy, V Valero, W T Yang, H M Kuerer
BACKGROUND: Patients with triple-negative breast cancer (TNBC) and a pathological complete response (pCR) after neoadjuvant chemotherapy may be suitable for non-surgical management. The goal of this study was to identify baseline clinicopathological variables that are associated with residual disease, and to evaluate the effect of neoadjuvant chemotherapy on both the invasive and ductal carcinoma in situ (DCIS) components in TNBC. METHODS: Patients with TNBC treated with neoadjuvant chemotherapy followed by surgical resection were identified...
February 21, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29464270/diabetes-modifies-the-role-of-prostanoids-and-potassium-channels-which-regulate-the-hypereactivity-of-the-rabbit-renal-artery-to-bnp
#2
José M Centeno, Luis Miranda-Gómez, Mikahela A López-Morales, Teresa Jover-Mengual, María C Burguete, Vannina G Marrachelli, María Castelló-Ruiz, Alicia Aliena-Valero, Enrique Alborch, Francisco J Miranda
Diabetic nephropathy is associated with increased risk of cardiovascular disease. B-type natriuretic peptide (BNP) plays an important role in cardiovascular pathophysiology and therapeutics. The aim of the present study was to investigate the influence of experimental diabetes on the mechanisms that regulate the relaxant response of the rabbit renal artery to BNP. Arterial relaxations to BNP were enhanced in diabetic rabbits. Indomethacin enhanced BNP-induced relaxation in control rabbits but showed no effect in diabetic rabbits...
February 21, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29461685/enzymatic-production-of-biodiesel-strategies-to-overcome-methanol-inactivation
#3
REVIEW
Marina Lotti, Jürgen Pleiss, Francisco Valero, Pau Ferrer
Lipase-catalyzed transesterification of triglycerides and alcohols to obtain biodiesel is an environmentally friendly and sustainable route for fuels production since, besides proceeding in mild reaction conditions, it allows for the use of low-cost feedstocks that contain water and free fatty acids, for example non-edible oils and waste oils. In this contribution, we report on recent advances in the field and focus in particular on a major issue in the enzymatic process, the inactivation of most lipases caused by methanol, the preferred acyl acceptor used for alcoholysis...
February 20, 2018: Biotechnology Journal
https://www.readbyqxmd.com/read/29460033/factors-associated-with-improved-outcomes-for-metastatic-inflammatory-breast-cancer-patients
#4
Anna Weiss, Rhiana S Menen, Heather Y Lin, Yu Shen, Kelly J Rosso, Simona Shaitelman, Wendy Woodward, Vicente Valero, Naoto T Ueno, Isabelle Bedrosian, Gildy Babiera
PURPOSE: Controversy exists regarding the role of locoregional therapy for stage IV inflammatory breast cancer (IBC). This study aims to determine indicators of prognosis, including primary tumor resection, for stage IV IBC patients. METHODS: Using the National Cancer Data Base, female patients diagnosed 2010-2013 with unilateral a priori metastatic T4d invasive adenocarcinoma of the breast were identified. We conducted propensity score matched analysis to balance confounders of surgery versus no-surgery...
February 19, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29459996/robotic-surgery-in-public-hospitals-of-latin-america-a-castle-of-sand
#5
Fernando P Secin, Rafael Coelho, Juan I Monzó Gardiner, Jose Gadú Campos Salcedo, Roberto Puente, Levin Martínez, Diana Finkelstein, Rair Valero, Antonio León, Daniel Angeloni, José Rozanec, Milton Berger, Leandro Totti Cavazzola, Eliney Ferreira Faria, Roberto Días Machado, Felipe Lott, Franz Campos, Jorge G Morales Montor, Carlos Sánchez Moreno, Hugo Dávila Barrios
INTRODUCTION: There is no information about the evolution of robotic programs in public hospitals of Latin-America. OBJECTIVE: To describe the current status and functioning of robotic programs in Latin-American public hospitals since their beginning to date. METHODS: We conducted a survey among leading urologists working at public hospitals of Latin-America who had acquired the Da Vinci laparoscopic-assisted robotic system. Questions included: date the program started, its utilization by other services, number and kind of surgeries, surgery paying system, surgery related deaths, occurrence and reasons of robotic program interruptions and its use for training purposes...
February 19, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29451394/clinical-application-of-microsampling-versus-conventional-sampling-techniques-in-the-quantitative-bioanalysis-of-antibiotics-a-systematic-review
#6
Yarmarly C Guerra Valero, Steven C Wallis, Jeffrey Lipman, Christophe Stove, Jason A Roberts, Suzanne L Parker
Conventional sampling techniques for clinical pharmacokinetic studies often require the removal of large blood volumes from patients. This can result in a physiological or emotional burden, particularly for neonates or pediatric patients. Antibiotic pharmacokinetic studies are typically performed on healthy adults or general ward patients. These may not account for alterations to a patient's pathophysiology and can lead to suboptimal treatment. Microsampling offers an important opportunity for clinical pharmacokinetic studies in vulnerable patient populations, where smaller sample volumes can be collected...
February 16, 2018: Bioanalysis
https://www.readbyqxmd.com/read/29442527/decreased-generation-of-c-terminal-fragments-of-apoer2-and-increased-reelin-expression-in-alzheimer-s-disease
#7
Trinidad Mata-Balaguer, Inmaculada Cuchillo-Ibañez, Miguel Calero, Isidro Ferrer, Javier Sáez-Valero
Increasing evidence indicates that altered reelin signaling could contribute to synaptic dysfunction in Alzheimer's disease (AD). We found that reelin protein and mRNA levels were increased in the AD brain (particularly at advanced Braak stages in apolipoprotein E4 noncarriers), compared with that of control subjects. The β-amyloid protein (Aβ) impairs reelin activity and increases reelin expression through a mechanism that is not yet understood. To explore that mechanism, we examined the effect of Aβ42on DNA methylation of the RELN promoter and the processing of reelin receptor apolipoprotein E receptor 2 (ApoER2) in differentiated SH-SY5Y cells because ApoER2 C-terminal fragments (CTFs), generated after reelin binding, regulate reelin expression...
February 9, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29438857/modelling-the-growth-of-listeria-monocytogenes-in-mediterranean-fish-species-from-aquaculture-production
#8
Araceli Bolívar, Jean Carlos Correia Peres Costa, Guiomar D Posada-Izquierdo, Antonio Valero, Gonzalo Zurera, Fernando Pérez-Rodríguez
Over the last couple of decades, several studies have evaluated growth dynamics of L. monocytogenes in lightly processed and ready-to-eat (RTE) fishery products mostly consumed in Nordic European countries. Other fish species from aquaculture production are of special interest since their relevant consumption patterns and added value in Mediterranean countries, such as sea bream and sea bass. In the present study, the growth of L. monocytogenes was evaluated in fish-based juice (FBJ) by means of optical density (OD) measurements in a temperature range 2-20 °C under different atmosphere conditions (i...
February 5, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29426586/safety-of-raav2-2-nd4-gene-therapy-for-leber-hereditary-optic-neuropathy
#9
Catherine Vignal, Scott Uretsky, Serge Fitoussi, Anne Galy, Laure Blouin, Jean-François Girmens, Samuel Bidot, Nitza Thomasson, Céline Bouquet, Sonia Valero, Sandrine Meunier, Jean-Philippe Combal, Bernard Gilly, Barrett Katz, José-Alain Sahel
No abstract text is available yet for this article.
February 6, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29414318/genes-related-to-cell-mediated-cytotoxicity-and-interferon-response-are-induced-in-the-retina-of-european-sea-bass-upon-intravitreal-infection-with-nodavirus
#10
Yulema Valero, Bassima Boughlala, Marta Arizcun, Sonal Patel, Ingrid U Fiksdal, M Ángeles Esteban, Joaquín De Juan, José Meseguer, Elena Chaves-Pozo, Alberto Cuesta
Viral diseases are responsible for high rates of mortality and subsequent economic losses in modern aquaculture. The nervous necrosis virus (NNV) produces viral encephalopathy and retinopathy (VER), which affects the central nervous system, is considered one of the most serious viral diseases in marine aquaculture. Although some studies have localized NNV in the retina cells, none has dealt with immunity in the retina. Thus, for the first time, we intravitreally infected healthy specimens of European sea bass (Dicentrarchus labrax) with NNV with the aim of characterizing the immune response in the retina...
February 2, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29407532/the-involvement-of-crf1-receptor-within-the-basolateral-amygdala-and-dentate-gyrus-in-the-naloxone-induced-conditioned-place-aversion-in-morphine-dependent-mice
#11
E Valero, I Gómez-Milanés, P Almela, B Ribeiro Do Couto, M L Laorden, M V Milanés, C Núñez
Drug withdrawal-associated aversive memories trigger relapse to drug-seeking behavior. Corticotrophin-releasing factor (CRF) is an important mediator of the reinforcing properties of drugs of abuse. However, the involvement of CRF1 receptor (CRF1R) in aversive memory induced by opiate withdrawal has yet to be elucidated. We used the conditioned-place aversion (CPA) paradigm to evaluate the role of CRF1R on opiate withdrawal memory acquisition, along with plasticity-related processes that occur after CPA within the basolateral amygdala (BLA) and dentate gyrus (DG)...
January 30, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29401756/in-depth-proteomic-characterization-of-classical-and-non-classical-monocyte-subsets
#12
Víctor Segura, M Luz Valero, Laura Cantero, Javier Muñoz, Eduardo Zarzuela, Fernando García, Kerman Aloria, Javier Beaskoetxea, Jesús M Arizmendi, Rosana Navajas, Alberto Paradela, Paula Díez, Rosa Mª Dégano, Manuel Fuentes, Alberto Orfao, Andrés García Montero, Alba Garin-Muga, Fernando J Corrales, Manuel M Sánchez Del Pino
Monocytes are bone marrow-derived leukocytes that are part of the innate immune system. Monocytes are divided into three subsets: classical, intermediate and non-classical, which can be differentiated by their expression of some surface antigens, mainly CD14 and CD16. These cells are key players in the inflammation process underlying the mechanism of many diseases. Thus, the molecular characterization of these cells may provide very useful information for understanding their biology in health and disease. We performed a multicentric proteomic study with pure classical and non-classical populations derived from 12 healthy donors...
February 5, 2018: Proteomes
https://www.readbyqxmd.com/read/29394389/blackwater-fever-in-a-non-immune-patient-with-plasmodium-falciparum-malaria-after-intravenous-artesunate
#13
N Rodriguez-Valero, P Castro, G Martinez, J Marco Hernandez, S Fernandez, J Gascon, J M Nicolas
Blackwater fever was typically reported after quinine administration, although it is poor recognized in patients receiving artesunate. This case describes a blackwater fever in a non-immune patient after artesunate for severe malaria. It highlights the importance of monitoring haemolytic parameters in severe malaria to avoid renal impairment or severe anaemia.
January 1, 2018: Journal of Travel Medicine
https://www.readbyqxmd.com/read/29391261/nanomedicine-as-a-potential-approach-to-empower-the-new-strategies-for-the-treatment-of-preeclampsia
#14
REVIEW
Lucie Valero, Khair Alhareth, Sophie Gil, Edouard Lecarpentier, Vassilis Tsatsaris, Nathalie Mignet, Thierry Fournier, Karine Andrieux
Preeclampsia is a serious pregnancy disorder characterized by the onset of high blood pressure and proteinuria. Although the understanding of the disease is increasing, it remains without treatment, other than the delivery of the baby and the placenta. This review sets out to discuss some new developments and strategies in the treatment of preeclampsia. We briefly review the current knowledge on the preeclamptic pathophysiology. We then examine the recent trends in preeclampsia treatment and, in particular, the tracks of potential therapeutic targets...
January 31, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29390599/-antibiotic-diffusion-to-central-nervous-system
#15
REVIEW
J M Cabrera-Maqueda, L Fuentes Rumí, G Valero López, A E Baidez Guerrero, E García Molina, J Díaz Pérez, E García-Vázquez
Central nervous system (CNS) infections caused by pathogens with a reduced sensitivity to drugs are a therapeutic challenge. Transport of fluid and solutes is tightly controlled within CNS, where vasculature exhibits a blood-brain barrier (BBB).The entry of drugs, including antibiotics, into the cerebro-spinal fluid (CSF) is governed by molecular size, lipophilicity, plasma protein binding and their affinity to transport systems at the BBB. The ratio of the AUCCSF (Area under the curve in CSF)/AUCS (Area under the curve in serum) is the most accurate parameter to characterize drug penetration into the CSF...
January 31, 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29383137/polycomb-protein-ring1a-limits-hematopoietic-differentiation-in-myelodysplastic-syndromes
#16
Anna Palau, Anne-Kathrin Garz, Jeannine Diesch, Anabel Zwick, Roberto Malinverni, Vanesa Valero, Katrina Lappin, Raquel Casquero, Andreas Lennartsson, Johannes Zuber, Tomàs Navarro, Ken I Mills, Katharina S Götze, Marcus Buschbeck
Genetic lesions affecting epigenetic regulators are frequent in myelodysplastic syndromes (MDS). Polycomb proteins are key epigenetic regulators of differentiation and stemness that act as two multimeric complexes termed polycomb repressive complexes 1 and 2, PRC1 and PRC2, respectively. While components and regulators of PRC2 such as ASXL1 and EZH2 are frequently mutated in MDS and AML, little is known about the role of PRC1. To analyze the role of PRC1, we have taken a functional approach testing PRC1 components in loss- and gain-of-function experiments that we found overexpressed in advanced MDS patients or dynamically expressed during normal hematopoiesis...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29374384/a-phase-ii-study-of-tipifarnib-and-gemcitabine-in-metastatic-breast-cancer
#17
Clinton Yam, Rashmi K Murthy, Vicente Valero, Janio Szklaruk, Girish S Shroff, Carol J Stalzer, Aman U Buzdar, James L Murray, Wei Yang, Gabriel N Hortobagyi, Stacy L Moulder, Banu Arun
Background Tipifarnib is an orally active, competitive inhibitor of farnesyltransferase which has shown encouraging signs of activity either alone or when combined with other agents. Clinical studies of tipifarnib in combination with anti-estrogen therapy have yielded disappointing results. In contrast, tipifarnib appears to be synergistic in combination with anthracycline based chemotherapy. Here we report the results of the first prospective phase II trial evaluating the efficacy of the novel combination of tipifarnib and gemcitabine in the treatment of metastatic breast cancer...
January 27, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29370097/alternative-splicing-of-alpha-and-beta-synuclein-genes-plays-differential-roles-in-synucleinopathies
#18
REVIEW
Ana Gámez-Valero, Katrin Beyer
The synuclein family is composed of three members, two of which, α- and β-synuclein, play a major role in the development of synucleinopathies, including Parkinson's disease (PD) as most important movement disorder, dementia with Lewy bodies (DLB) as the second most frequent cause of dementia after Alzheimer's disease and multiple system atrophy. Whereas abnormal oligomerization and fibrillation of α-synuclein are now well recognized as initial steps in the development of synucleinopathies, β-synuclein is thought to be a natural α-synuclein anti-aggregant...
January 25, 2018: Genes
https://www.readbyqxmd.com/read/29367184/activating-technology-for-connected-health-in-cancer-protocol-for-a-research-and-training-program
#19
Nicola Mountford, Enrique Dorronzoro Zubiete, Threase Kessie, Begonya Garcia-Zapirain, Roberto Nuño-Solinís, David Coyle, Kristin B Munksgaard, Luis Fernandez-Luque, Octavio Rivera Romero, Matilde Mora Fernandez, Pedro Valero Jimenez, Ailish Daly, Ruth Whelan, Brian Caulfield
BACKGROUND: As cancer survival rates increase, the challenge of ensuring that cancer survivors reclaim their quality of life (QoL) becomes more important. This paper outlines the research element of a research and training program that is designed to do just that. OBJECTIVE: Bridging sectors, disciplines, and geographies, it brings together eight PhD projects and students from across Europe to identify the underlying barriers, test different technology-enabled rehabilitative approaches, propose a model to optimize the patient pathways, and examine the business models that might underpin a sustainable approach to cancer survivor reintegration using technology...
January 24, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29366281/genetic-testing-of-familial-hypercholesterolemia-monogenic-form-and-polygenic-contribution-to-cardiovascular-risk
#20
Philippe Couvert, Philippe Giral, Pierre-Yves Boelle, Valérie Carreau, Sophie Béliard, Jean-Marc Lacorte, Philippe Lesnik, Francois Paillard, René Valéro, Annelies Rotthier, Eric Bruckert, Alain Carrié
No abstract text is available yet for this article.
August 2017: Atherosclerosis
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