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https://www.readbyqxmd.com/read/28214425/favorable-cardiovascular-risk-factor-profile-is-associated-with-lower-healthcare-expenditure-and-resource-utilization-among-adults-with-diabetes-mellitus-free-of-established-cardiovascular-disease-2012-medical-expenditure-panel-survey-meps
#1
David I Feldman, Javier Valero-Elizondo, Joseph A Salami, Jamal S Rana, Oluseye Ogunmoroti, Chukwuemeka U Osondu, Erica S Spatz, Salim S Virani, Ron Blankstein, Michael J Blaha, Emir Veledar, Khurram Nasir
BACKGROUND AND AIMS: Given the prevalence and economic burden of diabetes mellitus (DM), we studied the impact of a favorable cardiovascular risk factor (CRF) profile on healthcare expenditures and resource utilization among individuals without cardiovascular disease (CVD), by DM status. METHODS: 25,317 participants were categorized into 3 mutually-exclusive strata: "Poor", "Average" and "Optimal" CRF profiles (≥4, 2-3, 0-1 CRF, respectively). Two-part econometric models were utilized to study cost data...
February 9, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28211351/quality-indicators-of-asthma-care-derived-from-the-spanish-guidelines-for-asthma-management-gema-4-0-a-multidisciplinary-team-report
#2
S Quirce, J Delgado, L M Entrenas, M Grande, C Llorente, A López Viña, E Martínez Moragón, E Mascarós, J Molina, J M Olaguibel, L A Pérez de Llano, M Perpiñá Tordera, J A Quintano, M Rodríguez, M Román-Rodriguez, J Sastre, J A Trigueros, A L Valero, A C Zoni, V Plaza
No abstract text is available yet for this article.
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28211280/gastric-invagination-in-adults-as-a-rare-cause-of-constitutional-syndrome
#3
Cristina Dávila Arias, Ana Milena Muñoz, María Ángeles Valero González, Mariano Céspedes Mas
This article describes and illustrates the case of an adult patient with clinical symptoms of constitutional syndrome, postprandial discomfort and a mass in the left lateral abdominal region caused by a gastric intussusception with a fundal adenoma as the head of the invagination. The intussusception was diagnosed by MRI (magnetic resonance imaging).
February 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28208220/allergic-respiratory-disease-different-allergens-different-symptoms
#4
Antonio Valero, Santiago Quirce, Ignacio Dávila, Julio Delgado, Javier Domínguez-Ortega
BACKGROUND: Spanish population is rather homogeneous in its genetic and socio-cultural characteristics, but allergen sensitization shows wide geographical variations. We aimed at assessing whether sensitization to different allergens in the diverse geographical areas induced different clinical and quality of life characteristics in adult patients with a first-time diagnosis of rhinitis and/or asthma. METHODS: Two sequential, identically designed studies were carried out to evaluate such associations (PERFILAR I and II)...
February 16, 2017: Allergy
https://www.readbyqxmd.com/read/28199747/outcomes-in-patients-with-early-stage-breast-cancer-who-underwent-a-21-gene-expression-assay
#5
Carlos H Barcenas, Akshara Raghavendra, Arup K Sinha, Masood Pasha Syed, Limin Hsu, Modesto G Patangan, Mariana Chavez-MacGregor, Yu Shen, Gabriel H Hortobagyi, Vicente Valero, Sharon H Giordano, Naoto T Ueno, Debu Tripathy
BACKGROUND: Invasive disease-free survival (IDFS) rates are excellent in patients with breast cancer (BC) with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-), axillary lymph node-negative (LN-) tumors with a 21-gene expression assay recurrence score (RS) of 0 to 10. However, to the authors' knowledge, the outcomes among patients with an RS of 11 to 25 who are treated with endocrine therapy alone are unknown. METHODS: In this retrospective single-institution study, the authors described the characteristics of patients with HR+, HER2-, LN- BC who underwent a 21-gene expression assay...
February 15, 2017: Cancer
https://www.readbyqxmd.com/read/28192482/characterization-of-the-disruption-of-neural-control-strategies-for-dynamic-fingertip-forces-from-attractor-reconstruction
#6
Lorenzo Peppoloni, Emily L Lawrence, Emanuele Ruffaldi, Francisco J Valero-Cuevas
The Strength-Dexterity (SD) test measures the ability of the pulps of the thumb and index finger to compress a compliant and slender spring prone to buckling at low forces (<3N). We know that factors such as aging and neurodegenerative conditions bring deteriorating physiological changes (e.g., at the level of motor cortex, cerebellum, and basal ganglia), which lead to an overall loss of dexterous ability. However, little is known about how these changes reflect upon the dynamics of the underlying biological system...
2017: PloS One
https://www.readbyqxmd.com/read/28173876/high-plasticity-of-axonal-pathology-in-alzheimer-s-disease-mouse-models
#7
Lidia Blazquez-Llorca, Susana Valero-Freitag, Eva Ferreira Rodrigues, Ángel Merchán-Pérez, J Rodrigo Rodríguez, Mario M Dorostkar, Javier DeFelipe, Jochen Herms
Axonal dystrophies (AxDs) are swollen and tortuous neuronal processes that are associated with extracellular depositions of amyloid β (Aβ) and have been observed to contribute to synaptic alterations occurring in Alzheimer's disease. Understanding the temporal course of this axonal pathology is of high relevance to comprehend the progression of the disease over time. We performed a long-term in vivo study (up to 210 days of two-photon imaging) with two transgenic mouse models (dE9xGFP-M and APP-PS1xGFP-M)...
February 7, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/28168862/increased-systemic-cytokine-chemokine-expression-in-asthmatic-and-non-asthmatic-patients-with-bacterial-viral-or-mixed-lung-infection
#8
Maria J Giuffrida, Nereida Valero, Jesus Mosquera, Anyelo Duran, Francisco Arocha, Betulio Chacín, Luz Marina Espina, Jenifer Gotera, John Bermudez, Alibeth Mavarez, Melchor Alvarez-Mon
This study was aimed to determine the profiles of serum cytokines (IL-1β, TNF-α, IL-4, IL-5) and chemokines (MCP-1: monocyte chemoattract protein-1 and RANTES: regulated on activation normal T cell expressed and secreted) in individuals with an asthmatic versus a non-asthmatic background with bacterial, viral or mixed acute respiratory infection. Asthmatic (n=14) and non- asthmatic (n=29) patients with acute viral, bacterial or mixed (bacterial and viruses) respiratory infection were studied. Patients were also analyzed as individuals with pneumonia or bronchitis...
February 7, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28168147/self-supported-polypyrrole-polyvinylsulfate-films-electrochemical-synthesis-characterization-and-sensing-properties-of-their-redox-reactions
#9
Toribio F Otero, Lluis X Martinez-Soria, Johanna Schumacher, Laura Valero, Victor H Pascual
Thick films of polypyrrole/polyvinylsulfate (PPy/PVS) blends were electrogenerated on stainless-steel electrodes under potentiostatic conditions from aqueous solution. The best electropolymerization potential window was determined by cyclic voltammetry. After removing the film from the back metal, self-supported electrodes were obtained. Voltammetric, coulovoltammetric, and chronoamperometric responses from a LiClO4 aqueous solution indicated the formation of an energetically stable structure beyond a reduction threshold of the material...
February 2017: ChemistryOpen
https://www.readbyqxmd.com/read/28168140/self-supported-polypyrrole-polyvinylsulfate-films-electrochemical-synthesis-characterization-and-sensing-properties-of-their-redox-reactions
#10
Toribio F Otero, Lluis X Martinez-Soria, Johanna Schumacher, Laura Valero, Victor H Pascual
Invited for this month's cover picture is the group of Professor Toribio F. Otero at the Centre for Electrochemistry, Intelligent Materials and Devices at the Polytechnic University of Cartagena (Spain). The cover picture shows an electrochemical cell as well as three representative cyclic voltammetric responses, displaying the electrolyte potential window, the monomer oxidation-polymerization potential range, and the polymer oxidation-reduction potential window. For more details, read the full text of the Full Paper at 10...
February 2017: ChemistryOpen
https://www.readbyqxmd.com/read/28161879/effect-of-inulin-on-the-viability-of-l-plantarum-during-storage-and-in-vitro-digestion-and-on-composition-parameters-of-vegetable-fermented-juices
#11
Estefanía Valero-Cases, María José Frutos
The prebiotic effect of different concentrations of inulin (0, 1 and 2%) on the growth and survival of Lactobacillus plantarum (LP) CECT 220 in blended carrot and orange juices was investigated after 24 h of fermentation, during 30 days of storage at 4 °C and through the phases of gastrointestinal digestion after different storage periods. Microbiological and chemical determinations were also carried out in all juices. The lactic fermentation increased the shelf life of the fermented juices with inulin...
February 4, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/28159566/a-systematic-review-of-self-administered-questionnaires-for-the-functional-assessment-of-patients-with-knee-disabilities-adapted-into-spanish
#12
S Gómez-Valero, F García-Pérez, M T Flórez-García, J C Miangolarra-Page
OBJECTIVE: The aim of this study was to conduct a systematic review of self-administered knee-disability functional assessment questionnaires adapted to Spanish, analysing the quality of the transcultural adaptation procedure and the psychometric properties of the new version. MATERIAL AND METHODS: A search was conducted in the main biomedical databases to find knee-function assessment scales adapted into Spanish, in order to assess their questionnaire adaptation process as well as their psychometric properties...
January 31, 2017: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/28157787/nonclinical-evaluation-of-the-new-topical-hemostatic-agent-tt-173-for-skin-grafting-procedures
#13
Santiago Rojas Codina, José Raúl Herance, Alberto Centeno, Javier Valero, Belén Arias, Ignasi Miquel, Pilar Sánchez, Esther Rincón, Ramón López, Jesús Murat
Blood loss during grafting surgery represents a major concern of this procedure and the development of hemostatic agents for this indication is highly desirable. TT-173 is the first biologically active treatment based on tissue factor instead of thrombin. This study sought to investigate the efficacy, systemic absorption, and toxicology of TT-173 in animal models to support clinical evaluation of the product in donor sites of patients subjected to skin grafting. Procoagulant efficacy of 148 μg of TT-173 was evaluated in pigs in presence and absence of anticoagulant treatment with unfractioned heparin...
January 31, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28154975/actn3-genotype-influences-exercise-induced-muscle-damage-during-a-marathon-competition
#14
Juan Del Coso, Marjorie Valero, Juan José Salinero, Beatriz Lara, Germán Díaz, César Gallo-Salazar, Diana Ruiz-Vicente, Francisco Areces, Carlos Puente, Juan Carlos Carril, Ramón Cacabelos
PURPOSE: Exercise-induced muscle damage has been identified as one of the main causes of the progressive decrease in running and muscular performance in marathoners. The aim of this investigation was to determine the influence of the ACTN3 genotype on exercise-induced muscle damage produced during a marathon. METHODS: Seventy-one experienced runners competed in a marathon race. Before and after the race, a sample of venous blood was obtained and maximal voluntary leg muscle power was measured during a countermovement jump...
February 2, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28135148/long-term-prognostic-risk-after-neoadjuvant-chemotherapy-associated-with-residual-cancer-burden-and-breast-cancer-subtype
#15
W Fraser Symmans, Caimiao Wei, Rebekah Gould, Xian Yu, Ya Zhang, Mei Liu, Andrew Walls, Alex Bousamra, Maheshwari Ramineni, Bruno Sinn, Kelly Hunt, Thomas A Buchholz, Vicente Valero, Aman U Buzdar, Wei Yang, Abenaa M Brewster, Stacy Moulder, Lajos Pusztai, Christos Hatzis, Gabriel N Hortobagyi
Purpose To determine the long-term prognosis in each phenotypic subset of breast cancer related to residual cancer burden (RCB) after neoadjuvant chemotherapy alone, or with concurrent human epidermal growth factor receptor 2 (HER2)-targeted treatment. Methods We conducted a pathologic review to measure the continuous RCB index (wherein pathologic complete response has RCB = 0; residual disease is categorized into three predefined classes of RCB index [RCB-I, RCB-II, and RCB-III]), and yp-stage of residual disease...
January 30, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28133884/entangled-fates-of-holobiont-genomes-during-invasion-nested-bacterial-and-host-diversities-in-caulerpa-taxifolia
#16
S Arnaud-Haond, T Aires, R Candeias, S J L Teixeira, C M Duarte, M Valero, E A Serrão
Successful prevention and mitigation of biological invasions requires retracing the initial steps of introduction, as well as understanding key elements enhancing the adaptability of invasive species. We studied the genetic diversity of the green alga Caulerpa taxifolia and its associated bacterial communities in several areas around the world. The striking congruence of α and ß diversity of the algal genome and endophytic communities reveals a tight association, supporting the holobiont concept as best describing the unit of spreading and invasion...
January 30, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28126447/ehtic-study-evaluation-of-a-new-hemostatic-agent-based-on-tissue-factor-in-skin-grafting-procedures
#17
Santiago Rojas, M Dolores Pérez Del Caz, Juan Ramón Esteban Vico, Eloísa Villaverde, Abel Llinas, José Ramón Martínez, Carlos Brage, Javier Valero, Alba González Rodríguez, Juan Garcia Barreiro, Eugenia López-Suso, Jose Luis Fernandez-Cañamaque, Ramón López, Jesus Murat
BACKGROUND: Excessive bleeding is a major concern in scar debridement and grafting procedures. TT-173 is a new topical hemostatic agent based on recombinant human tissue factor that has shown promising results in patients who underwent tooth extraction. EHTIC study sought to evaluate the efficacy and safety of TT-173 to reduce the bleeding in donor sites of skin grafting procedures. METHODS: EHTIC study was a phase II, randomized, parallel, double blind, placebo controlled trial...
January 23, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28125276/molecular-factors-involved-in-the-hypolipidemic-and-insulin-sensitizing-effects-of-a-ginger-zingiber-officinale-roscoe-extract-in-rats-fed-a-high-fat-diet
#18
Natalia de Las Heras, María Valero-Muñoz, Beatriz Martín-Fernández, Sandra Ballesteros, Antonio López-Farré, Baltasar Ruiz-Roso, Vicente Lahera
Hypolipidemic and hypoglycemic properties of ginger in animal models have been reported. However, information related to the mechanisms and factors involved in the metabolic effects of ginger at a hepatic level are limited. The aim of the present study was to investigate molecular factors involved in the hypoglycemic and hypolipidemic effects of a hydroethanolic ginger extract (GE) in the liver of rats fed a high-fat diet (HFD). The study was conducted in male Wistar rats divided into the following 3 groups: (i) Rats fed a standard diet (3...
February 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28118384/multi-robot-coalitions-formation-with-deadlines-complexity-analysis-and-solutions
#19
Jose Guerrero, Gabriel Oliver, Oscar Valero
Multi-robot task allocation is one of the main problems to address in order to design a multi-robot system, very especially when robots form coalitions that must carry out tasks before a deadline. A lot of factors affect the performance of these systems and among them, this paper is focused on the physical interference effect, produced when two or more robots want to access the same point simultaneously. To our best knowledge, this paper presents the first formal description of multi-robot task allocation that includes a model of interference...
2017: PloS One
https://www.readbyqxmd.com/read/28109639/factors-associated-with-a-long-mean-hospital-stay-in-patients-hospitalized-with-tuberculosis
#20
María Del Carmen Vera Sánchez-Rojas, Emma Muñoz Pérez, Ángeles Muñoz Pérez, Salvador Valero Cifuentes, Eva García Villalba, María de la Paz Egea Campoy, Alfredo Cano Sánchez, Enrique Bernal Morell
No abstract text is available yet for this article.
January 18, 2017: Archivos de Bronconeumología
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