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https://www.readbyqxmd.com/read/28079855/acute-sarcoid-myopathy-a-case-report-and-literature-review
#1
José Miguel Gómez-Verdú, Salvador Valero Cifuentes, Francisco Pastor Quirante, Francisco Román López-Andreu
Sarcoidosis is a worldwide spread disease with brad clinical spectrum, in which the pulmonary involvement is the main manifestation (more than 90% of cases); nevertheless, extrathoracic symptoms can predominate in the clinical picture and they may even be the first manifestation. One of them is the skeletal muscle involvement that normally is chronic and silent, with poor response to treatment with glucocorticoids. However, in some cases, it has an acute presentation. We present a case of a 61-year-old man with diagnosis of sarcoidosis whe were evaluated for proximal lower limb weakness within few days of evolution...
December 23, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/28072463/pilot-study-of-mobile-phone-technology-in-allergic-rhinitis-in-european-countries-the-mask-rhinitis-study
#2
J Bousquet, D P Caimmi, A Bedbrook, M Bewick, P W Hellings, P Devillier, S Arnavielhe, C Bachert, K C Bergmann, G W Canonica, N Chavannes, A A Cruz, R Dahl, P Demoly, G De Vries, E Mathieu-Dupas, A Fink Wagner, J Fonseca, N Guldemond, T Haahtela, B Hellqvist-Dahl, J Just, T Keil, L Klimek, M L Kowalski, M Kuitunen, P Kuna, V Kvedariene, D Laune, A M Pereira, P Carreiro-Martins, E Melén, M Morais-Almeida, J Mullol, A Muraro, R Murray, L Nogueira-Silva, N G Papadopoulos, G Passalacqua, F Portejoie, D Price, D Ryan, B Samolinski, A Sheikh, V Siroux, O Spranger, A Todo Bom, P V Tomazic, A Valero, E Valovirta, A Valiulis, O VandenPlas, S van der Meulen, M van Eerd, M Wickman, T Zuberbier
BACKGROUND: The use of Apps running on smartphones and tablets profoundly affects medicine. The MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) App (Allergy Diary) assesses allergic rhinitis symptoms, disease control and impact on patients' lives. It is freely available in 20 countries (iOS and Android platforms). AIMS: To assess in a pilot study whether (i) Allergy Diary users were able to properly provide baseline characteristics (ii) simple phenotypic characteristics based upon data captured by the Allergy Diary could be identified and (iii) information gathered by this study could suggest novel research questions...
January 10, 2017: Allergy
https://www.readbyqxmd.com/read/28062691/activating-mutations-and-translocations-in-the-guanine-exchange-factor-vav1-in-peripheral-t-cell-lymphomas
#3
Francesco Abate, Ana C da Silva-Almeida, Sakellarios Zairis, Javier Robles-Valero, Lucile Couronne, Hossein Khiabanian, S Aidan Quinn, Mi-Yeon Kim, Maria Antonella Laginestra, Christine Kim, Danilo Fiore, Govind Bhagat, Miguel Angel Piris, Elias Campo, Izidore S Lossos, Olivier A Bernard, Giorgio Inghirami, Stefano Pileri, Xosé R Bustelo, Raul Rabadan, Adolfo A Ferrando, Teresa Palomero
Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of non-Hodgkin lymphomas frequently associated with poor prognosis and for which genetic mechanisms of transformation remain incompletely understood. Using RNA sequencing and targeted sequencing, here we identify a recurrent in-frame deletion (VAV1 Δ778-786) generated by a focal deletion-driven alternative splicing mechanism as well as novel VAV1 gene fusions (VAV1-THAP4, VAV1-MYO1F, and VAV1-S100A7) in PTCL. Mechanistically these genetic lesions result in increased activation of VAV1 catalytic-dependent (MAPK, JNK) and non-catalytic-dependent (nuclear factor of activated T cells, NFAT) VAV1 effector pathways...
January 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28045654/information-systems-in-clinical-pharmacy-applied-to-parenteral-nutrition-management-and-traceability-a-systematic-review
#4
Josefa Martínez Gabarrón, Javier Sanz-Valero, Carmina Wanden-Berghe
OBJECTIVE: To review the scientific literature on clinical pharmacy information systems applied to parenteral nutrition (PN) management and traceability. METHOD: A systematic review of the documents retrieved from the MEDLINE (PubMed), Web of Science, Scopus, Cochrane Library, International Pharmaceutical Abstracts (IPA) and Google Scholar databases up to May, 2016. The terms used, as descriptors and free text, were: "Parenteral Nutrition" and "Drug Information Services"...
January 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/28041617/-postoperative-surveillance-in-neurosurgical-patients-usefulness-of-neurological-assessment-scores-and-bispectral-index
#5
Silvia Herrero, Enrique Carrero, Ricard Valero, Jose Rios, Neus Fábregas
BACKGROUND AND OBJECTIVES: We examined the additive effect of the Ramsay scale, Canadian Neurological Scale (CNS), Nursing Delirium Screening Scale (Nu-DESC), and Bispectral Index (BIS) to see whether along with the assessment of pupils and Glasgow Coma Scale (GCS) it improved early detection of postoperative neurological complications. METHODS: We designed a prospective observational study of two elective neurosurgery groups of patients: craniotomies (CG) and non-craniotomies (NCG)...
December 29, 2016: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/28032871/debate-multidisciplinar-de-expertos-asma-no-controlada-causas-consecuencias-y-posibles-soluciones
#6
V Plaza Moral, T Carrillo, J Delgado, L M Entrenas, E Martinez Moragón, J M Olaguibel, L Pérez de Llano, M Perpiñá, J Sastre, A Valero, S Quirce
  Fundamento. Numerosos estudios constatan que aproximadamente la mitad de la población asmática no está bien controlada. El objetivo de este trabajo fue analizar entre expertos las causas, consecuencias y las posibles soluciones del asma no controlada (ANC).  Material y métodos. Debate entre expertos en asma de las especialidades de Neumología, Alergología y Atención Primaria, estructurado en tres fases 1) Cuestionario para pulsar la opinión de los participantes en los diferentes elementos implicados del ANC; 2) Reunión presencial de los expertos, en la que se discutieron los resultados de la encuesta y se presentaron y debatieron ponencias sobre el diagnóstico, tratamiento y seguimiento del ANC; 3) Formulación de 83 ítems que fueron sometidos a consenso entre todos los participantes mediante el método Delphi...
November 21, 2016: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/28029407/management-of-chronic-spontaneous-urticaria-in-routine-clinical-practice-a-delphi-method-questionnaire-among-specialists-to-test-agreement-with-current-european-guidelines-statements
#7
A Giménez-Arnau, M Ferrer, J Bartra, I Jáuregui, M Labrador-Horrillo, J Ortiz de Frutos, J F Silvestre, J Sastre, M Velasco, A Valero
BACKGROUND: Chronic spontaneous urticaria (CSU) is a frequent clinical entity that often presents a diagnostic and therapeutic challenge. OBJECTIVE: To explore the degree of agreement that exists among the experts caring for patients with CSU diagnosis, evaluation, and management. METHODS: An online survey was conducted to explore the opinions of experts in CSU, address controversial issues, and provide recommendations regarding its definition, natural history, diagnosis, and treatment...
October 28, 2016: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28027203/developing-standardised-advanced-training-in-neuroanaesthesia-results-of-a-europe-wide-survey
#8
Ricard Valero, Michael H Nathanson, Dafna Willner, Neus Fàbregas, Federico Bilotta
No abstract text is available yet for this article.
February 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28019644/allergic-rhinitis-severity-can-be-assessed-using-a-visual-analogue-scale-in-mild-moderate-and-severe
#9
A Del Cuvillo, V Santos, J Montoro, J Bartra, I Davila, M Ferrer, I Jauregui, J Sastre, J Mullol, A Valero
BACKGROUND: Allergic rhinitis is a global healthcare problem due to its high prevalence, impact on individuals and socioeconomic burden for the nations. Allergic rhinitis severity evaluation is the key to a correct treatment, prevention of comorbidities and improving the quality of life of patients. This evaluation should be made with a simple, easy, fast but accurate and reliable methodology, both in a primary care and specialist setting. The visual analogue scale (VAS) meets all requirements to be the ideal tool to assess allergic rhinitis severity and has already been validated by using a single cut-off point, but this classification in two degrees of severity suffer from not allocating the patients uniformly and from giving a blind interval to classify the patients when the score is between 5 to 6 cm...
December 26, 2016: Rhinology
https://www.readbyqxmd.com/read/28008364/interfacial-pressure-and-shear-sensor-system-for-fingertip-contact-applications
#10
Maria Valero, Nick Hale, Jing Tang, Liudi Jiang, Mike McGrath, Jianliang Gao, Piotr Laszczak, David Moser
This Letter presents a capacitive-based sensor system for fingertip contact applications. It is capable of simultaneously measuring normal (pressure) and tangential (shear) stresses at the interface between a fingertip and external objects. This could be potentially exploitable for applications in the fields of upper limb prosthetics, robotics, hand rehabilitation and so on. The system was calibrated and its performance was tested using a test machine. To do so, specific test protocols reproducing typical stress profiles in fingertip contact interactions were designed...
December 2016: Healthcare Technology Letters
https://www.readbyqxmd.com/read/28000455/programa-de-comedores-escolares-de-la-comunidad-de-madrid-2001-2015-dise%C3%A3-o-protocolo-metodolog%C3%A3-a-y-actualizaci%C3%A3-n
#11
Teresa Valero Gaspar, Susana Del Pozo de la Calle, Emma Ruiz Moreno, Osé Manuel Ávila Torres, Gregorio Varela-Moreiras, Carmen Cuadrado Vives
Introducción: a finales del siglo xx, no se conocía con precisión si la comida del comedor escolar contribuía adecuadamente a la dieta de la población infantil. Además, este servicio complementario no se contemplaba en el proyecto educativo del centro pese a considerarse fundamental en todas sus dimensiones.Objetivo: describir el origen y desarrollo del programa de comedores escolares de la Comunidad de Madrid (CM) en 15 años desde su implantación.Métodos: se elaboró una normativa a cumplir por las empresas de restauración, y que contemplaba aspectos nutricionales y de composición y variedad de los menús, que se utilizó en los concursos para acceder a la prestación del servicio de comedor escolar, publicados en los años 2001, 2002, 2005, 2009 y 2013...
November 29, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27999855/building-bridges-for-innovation-in-ageing-synergies-between-action-groups-of-the-eip-on-aha
#12
J Bousquet, M Bewick, A Cano, P Eklund, G Fico, N Goswami, N A Guldemond, D Henderson, M J Hinkema, G Liotta, A Mair, W Molloy, A Monaco, I Monsonis-Paya, A Nizinska, H Papadopoulos, A Pavlickova, S Pecorelli, A Prados-Torres, R E Roller-Wirnsberger, D Somekh, C Vera-Muñoz, F Visser, J Farrell, J Malva, K Andersen Ranberg, T Camuzat, A M Carriazo, G Crooks, Z Gutter, G Iaccarino, E Manuel de Keenoy, G Moda, L Rodriguez-Mañas, T Vontetsianos, C Abreu, J Alonso, C Alonso-Bouzon, J Ankri, M T Arredondo, F Avolio, A Bedbrook, A Z Białoszewski, H Blain, R Bourret, M F Cabrera-Umpierrez, A Catala, R O'Caoimh, M Cesari, N H Chavannes, J Correia-da-Sousa, T Dedeu, M Ferrando, M Ferri, W J Fokkens, F Garcia-Lizana, O Guérin, P W Hellings, T Haahtela, M Illario, M C Inzerilli, K C Lodrup Carlsen, P Kardas, T Keil, M Maggio, A Mendez-Zorrilla, E Menditto, J Mercier, J P Michel, R Murray, M Nogues, I O'Byrne-Maguire, D Pappa, A S Parent, M Pastorino, C Robalo-Cordeiro, B Samolinski, P Siciliano, A M Teixeira, S I Tsartara, A Valiulis, O Vandenplas, T Vasankari, B Vellas, M Vollenbroek-Hutten, M Wickman, A Yorgancioglu, T Zuberbier, M Barbagallo, G W Canonica, L Klimek, S Maggi, W Aberer, C Akdis, I M Adcock, I Agache, C Albera, F Alonso-Trujillo, M Angel Guarcia, I Annesi-Maesano, J Apostolo, S H Arshad, V Attalin, A Avignon, C Bachert, I Baroni, E Bel, M Benson, C Bescos, F Blasi, C Barbara, K C Bergmann, P L Bernard, S Bonini, P J Bousquet, B Branchini, C E Brightling, V Bruguière, C Bunu, A Bush, D P Caimmi, M A Calderon, G Canovas, V Cardona, K H Carlsen, A Cesario, E Chkhartishvili, R Chiron, T Chivato, K F Chung, M d'Angelantonio, G De Carlo, D Cholley, F Chorin, B Combe, B Compas, D J Costa, E Costa, O Coste, A-L Coupet, G Crepaldi, A Custovic, R Dahl, S E Dahlen, P Demoly, P Devillier, A Didier, A T Dinh-Xuan, R Djukanovic, D Dokic, G Du Toit, R Dubakiene, A Dupeyron, R Emuzyte, A Fiocchi, A Wagner, M Fletcher, J Fonseca, B Fougère, A Gamkrelidze, G Garces, J Garcia-Aymeric, B Garcia-Zapirain, B Gemicioğlu, C Gouder, B Hellquist-Dahl, I Hermosilla-Gimeno, D Héve, C Holland, M Humbert, M Hyland, S L Johnston, J Just, M Jutel, I P Kaidashev, M Khaitov, O Kalayci, A F Kalyoncu, W Keijser, H Kerstjens, J Knezović, M Kowalski, G H Koppelman, T Kotska, M Kovac, I Kull, P Kuna, V Kvedariene, V Lepore, W MacNee, M Maggio, A Magnan, I Majer, P Manning, M Marcucci, T Marti, M Masoli, E Melen, N Miculinic, F Mihaltan, B Milenkovic, J Millot-Keurinck, H Mlinarić, I Momas, S Montefort, M Morais-Almeida, T Moreno-Casbas, R Mösges, J Mullol, R Nadif, M Nalin, E Navarro-Pardo, K Nekam, G Ninot, D Paccard, S Pais, E Palummeri, P Panzner, N K Papadopoulos, C Papanikolaou, G Passalacqua, E Pastor, M Perrot, D Plavec, T A Popov, D S Postma, D Price, N Raffort, J C Reuzeau, J M Robine, F Rodenas, F Robusto, N Roche, A Romano, V Romano, J Rosado-Pinto, F Roubille, F Ruiz, D Ryan, T Salcedo, P Schmid-Grendelmeier, H Schulz, H J Schunemann, E Serrano, A Sheikh, M Shields, N Siafakas, N Scichilone, P Siciliano, I Skrindo, H A Smit, S Sourdet, E Sousa-Costa, O Spranger, T Sooronbaev, V Sruk, P J Sterk, A Todo-Bom, J Touchon, D Tramontano, M Triggiani, S I Tsartara, A L Valero, E Valovirta, E van Ganse, M van Hage, M van den Berge, O Vandenplas, M T Ventura, I Vergara, G Vezzani, D Vidal, G Viegi, M Wagemann, B Whalley, M Wickman, N Wilson, P K Yiallouros, M Žagar, A Zaidi, M Zidarn, E J Hoogerwerf, J Usero, R Zuffada, A Senn, B de Oliveira-Alves
The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27997390/effect-of-filter-media-thickness-on-the-performance-of-sand-drying-beds-used-for-faecal-sludge-management
#13
M Manga, B E Evans, M A Camargo-Valero, N J Horan
The effect of sand filter media thickness on the performance of faecal sludge (FS) drying beds was determined in terms of: dewatering time, contaminant load removal efficiency, solids generation rate, nutrient content and helminth eggs viability in the dried sludge. A mixture of ventilated improved pit latrine sludge and septage in the ratio 1:2 was dewatered using three pilot-scale sludge drying beds with sand media thicknesses of 150, 250 and 350 mm. Five dewatering cycles were conducted and monitored for each drying bed...
December 2016: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/27987457/synergistic-performance-of-lecithin-and-glycerol-monostearate-in-oil-water-emulsions
#14
María I Moran-Valero, Víctor M Pizones Ruiz-Henestrosa, Ana M R Pilosof
The effects of the combination of two low-molecular weight emulsifiers (lecithin and glycerol-monostearate (GMS)) on the stability, the dynamic interfacial properties and rheology of emulsions have been studied. Different lecithin/GMS ratios were tested in order to assess their impact in the formation and stabilization of oil in water emulsions. The combination of the two surfactants showed a synergistic behaviour, mainly when combined at the same ratio. The dynamic film properties and ζ-potential showed that lecithin dominated the surface of oil droplets, providing stability to the emulsions against flocculation and coalescence, while allowing the formation of small oil droplets...
December 11, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27979629/estimation-of-potential-donors-after-cardiocirculatory-death-in-elche-university-general-hospital-alicante-spain
#15
E Tenza, R Valero, V Arraez
OBJECTIVE: To evaluate the number and characteristics of potential organ donors among cardiocirculatory death cases. DESIGN AND SETTING: A retrospective observational study was made of individuals between 15-65 years of age who died in the period 2006-2014 in Elche University General Hospital (Alicante, Spain). INTERVENTION: A univariate analysis and binary logistic regression predictive model were performed to discriminate factors related to donation contraindication...
December 12, 2016: Medicina Intensiva
https://www.readbyqxmd.com/read/27971744/an-update-of-real-world-cost-utility-evaluation-of-multiple-myeloma-treatments-in-stem-cells-transplant-patients
#16
F Parada-Saavedra, J A Schoenenberger, M Gilabert Sotoca, I Mangues-Bafalluy, J Rius-Perera, L Vallez-Valero
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27970314/tct-148-role-of-chronic-total-occlusion-in-patients-undergoing-primary-angioplasty
#17
Eva Rumiz, Alberto Berenguer, Juan Vicente Vilar, Dario Sanmiguel, Andres Cubillos, Pablo Almela, Isidoro López, Ernesto Valero, Salvador Morell
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27967273/eccentric-overload-training-in-team-sports-functional-performance-constant-bilateral-vertical-vs-variable-unilateral-multidirectional-movements
#18
Oliver Gonzalo-Skok, Julio Tous-Fajardo, Carlos Valero-Campo, César Berzosa, Ana Vanessa Bataller, José Luis Arjol-Serrano, Gerard Moras, Alberto Mendez-Villanueva
PURPOSE: This study analyzed the effects of two different eccentric overload training (EOT) programs, using a rotational conical-pulley, on functional performance in team-sports players. A traditional movement paradigm (i.e., squat) including several sets of one bilateral and vertical movement was compared to a novel paradigm including a different exercise in each set of unilateral and multidirectional movements. METHODS: Forty-eight amateur/semiprofessional team-sport players were randomly assigned to an EOT program including either the same bilateral-vertical (CBV, n=24) movement (squat) or different unilateral-multidirectional (VUMD, n=24) movements...
December 14, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27965588/unilateral-eccentric-contraction-of-the-plantarflexors-leads-to-bilateral-alterations-in-leg-dexterity
#19
Akira Nagamori, Francisco J Valero-Cuevas, James M Finley
Eccentric contractions can affect musculotendon mechanical properties and disrupt muscle proprioception, but their behavioral consequences are poorly understood. We tested whether repeated eccentric contractions of plantarflexor muscles of one leg affected the dexterity of either leg. Twenty healthy male subjects (27.3 ± 4.0 yrs) compressed a compliant and slender spring prone to buckling with each isolated leg. The maximal instability they could control (i.e., the maximal average sustained compression force, or lower extremity dexterity force, LEDforce) quantified the dexterity of each leg...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27951706/competitive-and-synergistic-interactions-between-polymer-micelles-drugs-and-cyclodextrins-the-importance-of-drug-solubilization-locus
#20
Margarita Valero, Franca Castiglione, Andrea Mele, Marcelo A da Silva, Isabelle Grillo, Gustavo González-Gaitano, Cécile A Dreiss
Polymeric micelles, in particular PEO-PPO-based Pluronic, have emerged as promising drug carriers, while cyclodextrins (CD), cyclic oligosaccharides with an apolar cavity, have long been used for their capacity to form inclusion complexes with drugs. Dimethylated β-cyclodextrin (DIMEB) has the capacity to fully breakup F127 Pluronic micelles, while this effect is substantially hindered if drugs are loaded within the micellar aggregates. Four drugs were studied at physiological temperature: lidocaine (LD), pentobarbital sodium salt (PB), sodium naproxen (NP), and sodium salicylate (SAL); higher temperatures shift the equilibrium toward higher drug partitioning and lower drug/CD binding compared to 25 °C ( Valero, M...
December 13, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
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