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Nailfold videocapillaroscopy

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https://www.readbyqxmd.com/read/27889559/plasma-endothelial-microparticles-reflect-the-extent-of-capillaroscopic-alterations-and-correlate-with-the-severity-of-skin-involvement-in-systemic-sclerosis
#1
Małgorzata Michalska-Jakubus, Otylia Kowal-Bielecka, Vanessa Smith, Maurizio Cutolo, Dorota Krasowska
INTRODUCTION AND AIM: Endothelial microparticles (EMPs) are membrane-coated vesicles shed from endothelial cells and are considered markers of the endothelial state. It has been shown that total numbers of circulating EMPs are increased in patients with systemic sclerosis (SSc), but their clinical correlations have not yet been investigated in detail. We aimed to assess possible relationships between circulating EMPs and clinical as well as laboratory features among SSc patients with special attention to possible association with alteration in microvascular morphology objectified on nailfold videocapillaroscopy and clinical signs of microvascular complications...
November 23, 2016: Microvascular Research
https://www.readbyqxmd.com/read/27851803/the-2013-american-college-of-rheumatology-european-league-against-rheumatism-classification-criteria-for-systemic-sclerosis-could-classify-systemic-sclerosis-patients-at-earlier-stage-data-from-a-chinese-eustar-center
#2
Dong Xu, Yong Hou, Yuanfang Zheng, Yue Zheng, Mengtao Li, Xiaofeng Zeng
OBJECTIVES: To evaluate the performance of the 2013 ACR/EULAR classification criteria for systemic sclerosis (SSc) in clinical practice in a Chinese patient cohort, and to compare outcomes with the 1980 ACR criteria. METHODS: Patients clinically diagnosed with SSc between September 2013 and May 2015 were prospectively recruited from the EUSTAR database of the Peking Union Medical College Hospital. Diagnosis of SSc was based on the evaluation of three experienced rheumatologists...
2016: PloS One
https://www.readbyqxmd.com/read/27767971/inflammation-induced-microvascular-dysfunction-in-obesity-a-translational-approach
#3
Maria das Graças Coelho de Souza, Luiz Guilherme Kraemer-Aguiar, Eliete Bouskela
Obesity is a crescent epidemic in the world, affecting more than half a billion of adults worldwide. Obesity is associated to main cardiovascular risk factors, such as insulin resistance, type 2 diabetes mellitus, high blood pressure and dyslipidemia. The excessive adiposity causes a dysregulation of adipokines secretion by adipose tissue, upregulating the expression of pro-inflammatory adipokines and downregulating the anti-inflammatory ones. This scenario contributes for the appearance of atherosclerosis...
October 18, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27744392/effects-of-longterm-treatment-with-bosentan-and-iloprost-on-nailfold-absolute-capillary-number-fingertip-blood-perfusion-and-clinical-status-in-systemic-sclerosis
#4
Amelia Chiara Trombetta, Carmen Pizzorni, Barbara Ruaro, Sabrina Paolino, Alberto Sulli, Vanessa Smith, Maurizio Cutolo
OBJECTIVE: To quantify in patients with systemic sclerosis (SSc) the absolute nailfold capillary number/mm (the absolute number of capillaries, observable in the first row, in 1 mm per field) and fingertip blood perfusion (FBP) during longterm therapy with the endothelin receptor antagonist bosentan (BOSE) and the synthetic analog of prostacyclin PGI2 iloprost (ILO) by multiple diagnostic tools. Observed values were correlated with clinical outcomes. METHODS: Thirty patients with SSc already receiving intravenous ILO (80 μg/day) for 5 continuous days (every 3 mos) were recruited in the clinic...
October 1, 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27722973/primary-raynaud-s-phenomenon-and-nailfold-videocapillaroscopy-age-related-changes-in-capillary-morphology
#5
Carmen Pizzorni, Alberto Sulli, Vanessa Smith, Barbara Ruaro, Amelia Chiara Trombetta, Maurizio Cutolo, Sabrina Paolino
This study aimed to detect by nailfold videocapillaroscopy (NVC) the presence of age-related capillary morphological patterns in a large cohort of subjects affected by primary Raynaud's phenomenon (PRP). NVC was performed in 877 patients affected by PRP, divided into three age groups: <35, 35-55 and >55 years. The following qualitative parameters were assessed and compared in the three groups of patients: apical dilations, irregular (non-homogeneous) dilations, venous branch dilations, microhaemorrhages, tortuosities and subpapillary venous plexus visibility...
October 8, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27562035/serum-cxcl4-increase-in-primary-sj%C3%A3-gren-s-syndrome-characterizes-patients-with-microvascular-involvement-and-reduced-salivary-gland-infiltration-and-lymph-node-involvement
#6
Serena Vettori, Rosaria Irace, Antonella Riccardi, Daniela Iacono, Luciana Pellecchia, Lucia Vicedomini, Gabriele Valentini
CXCL4 is an antiangiogenic and immunomodulatory chemokine. We aimed to investigate serum levels of CXCL4 in primary Sjögren's syndrome (pSS), looking for associations with disease features. Thirty-nine consecutive pSS patients underwent clinical-serological assessment and nailfold videocapillaroscopy (NVC). Thirty-six patients and 30 controls affected by osteoarthritis were also investigated for serum levels of CXCL4 and soluble E-selectin (sE-selectin). CXCL4 was higher in pSS patients than in controls (1...
October 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27404031/short-term-effects-of-low-dose-estradiol-on-endothelial-function-and-blood-viscosity-in-nondiabetic-postmenopausal-overweight-women-a-double-blind-placebo-controlled-study
#7
Diogo G Panazzolo, Lucia H A da Silva, Priscila A Maranhão, Maria G C Souza, José F Nogueira Neto, Lenora M C S M Leão, Eliete Bouskela, Luiz G Kraemer-Aguiar
OBJECTIVE: The beneficial effects of estrogen on endothelial function depend on its integrity. This study evaluates the short-term effects of low-dose transdermal estradiol on endothelial function, insulin sensitivity, and blood viscosity in nondiabetic overweight/obese women. METHODS: Forty-four nondiabetic overweight/obese women with a history of recent menopause were randomly allocated, in a double-blind fashion, to receive transdermal estradiol (1 mg/d, n = 22) or placebo (n = 22)...
October 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27310203/effect-of-treatment-with-iloprost-with-or-without-bosentan-on-nailfold-videocapillaroscopic-alterations-in-patients-with-systemic-sclerosis
#8
Valentina Cestelli, Andreina Manfredi, Marco Sebastiani, Emanuela Praino, Francesca Cannarile, Dilia Giuggioli, Clodoveo Ferri
INTRODUCTION: Vascular involvement plays a decisive role in systemic sclerosis (SSc) pathogenesis; it is responsible for some important clinical manifestations of the disease such as Raynaud's phenomenon and digital ulcers (DU). Bosentan, a dual receptor endothelin antagonist, and iloprost, often in combination therapy, seems to be able to interfere with the scleroderma microangiopathy. OBJECTIVES: Aim of the study was to evaluate the effect of bosentan and iloprost on scleroderma microangiopathy, analyzed by means of capillaroscopic skin ulcer risk index (CSURI), in SSc patients treated for the prevention of DU...
June 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27307533/nailfold-videocapillaroscopy-alterations-in-dermatomyositis-and-systemic-sclerosis-toward-identification-of-a-specific-pattern
#9
Andreina Manfredi, Marco Sebastiani, Federica Campomori, Nicolò Pipitone, Dilia Giuggioli, Michele Colaci, Emanuela Praino, Clodoveo Ferri
OBJECTIVE: The term scleroderma pattern typically defines capillary abnormalities of scleroderma spectrum disorders, mainly systemic sclerosis (SSc) and dermatomyositis (DM). Our study aimed to investigate differences in nailfold videocapillaroscopy (NVC) between DM and SSc, with a cross-sectional and longitudinal evaluation. METHODS: NVC features of 29 consecutive patients with DM were compared with 90 patients with SSc categorized into the 3 subsets of scleroderma pattern: early, active, and late...
August 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27228628/a-new-way-of-thinking-about-systemic-sclerosis-the-opportunity-for-a-very-early-diagnosis
#10
Serena Guiducci, Silvia Bellando-Randone, Marco Matucci-Cerinic
Systemic sclerosis (SSc) is a heterogeneous chronic autoimmune disease that it is extremely difficult to diagnose in the early phase, resulting in a critical delay in therapy which is often begun when internal organ involvement is already irreversible. The ACR or LeRoy criteria have a low sensitivity for the early phases; these criteria were replaced by the ACR/EULAR 2013 criteria which improved the disease classification. Therefore, the SSc diagnosis may be delayed for several years after the onset of Raynaud's phenomenon (RP) and even after the onset of the first non-RP symptom...
March 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/27125627/evaluation-of-estimated-glomerular-filtration-rate-and-clinical-variables-in-systemic-sclerosis-patients
#11
Antonietta Gigante, Biagio Barbano, Guido Granata, Silvia Quarta, Antonio Amoroso, Felice Salsano, Rosario Cianci, Edoardo Rosato
OBJECTIVES: The most important renal complication of systemic sclerosis (SSc) is scleroderma renal crisis (SRC). Many patients demonstrate less severe renal complications, most likely associated with reduced renal blood flow and a consequent reduction in glomerular filtration rate (GFR). The mechanism of this slowly progressive form of chronic renal disease is unclear. The aim of this study was to evaluate GFR by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and the 7-variable Modification of Diet and Renal Disease (MDRD) equations in SSc patients and to correlate estimated GFR (eGFR) with clinical variables of the disease...
June 2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27115103/capillaroscopy-2016-new-perspectives-in-systemic-sclerosis
#12
C Pizzorni, A Sulli, V Smith, A Lladó, S Paolino, M Cutolo, B Ruaro
Systemic sclerosis (SSc) is an autoimmune disorder of unknown aetiology characterized by early impairment of the microvascular system. Nailfold microangiopathy and decreased peripheral blood perfusion are typical clinical aspects of SSc. The best method to evaluate vascular injury is nailfold videocapillaroscopy, which detects peripheral capillary morphology, and classifies and scores the abnormalities into different patterns of microangiopathy. Microangiopathy appears to be the best evaluable predictor of the disease development and has been observed to precede the other symptoms by many years...
January 2016: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/27111549/nailfold-videocapillaroscopic-features-and-other-clinical-risk-factors-for-digital-ulcers-in-systemic-sclerosis-a-multicenter-prospective-cohort-study
#13
Maurizio Cutolo, Ariane L Herrick, Oliver Distler, Mike O Becker, Emma Beltran, Patrick Carpentier, Clodoveo Ferri, Murat Inanç, Panayiotis Vlachoyiannopoulos, Harbajan Chadha-Boreham, Emmanuelle Cottreel, Thomas Pfister, Daniel Rosenberg, Juan V Torres, Vanessa Smith
OBJECTIVE: To identify nailfold videocapillaroscopic features and other clinical risk factors for new digital ulcers (DUs) during a 6-month period in patients with systemic sclerosis (SSc). METHODS: In this multicenter, prospective, observational cohort study, the videoCAPillaroscopy (CAP) study, we evaluated 623 patients with SSc from 59 centers (14 countries). Patients were stratified into 2 groups: a DU history group and a no DU history group. At enrollment, patients underwent detailed nailfold videocapillaroscopic evaluation and assessment of demographic characteristics, DU status, and clinical and SSc characteristics...
October 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27003713/serum-uric-acid-as-a-marker-of-microvascular-damage-in-systemic-sclerosis-patients
#14
Antonietta Gigante, Biagio Barbano, Giuseppe Barilaro, Silvia Quarta, Maria Ludovica Gasperini, Francesca Di Mario, Antonella Romaniello, Antonio Amoroso, Rosario Cianci, Edoardo Rosato
BACKGROUND: Microvascular damage of skin and internal organs is a hallmark of systemic sclerosis (SSc). Serum uric acid (UA) represents a marker of inflammation and endothelial dysfunction. The aims of this study were to evaluate the correlation between serum UA and intrarenal arterial stiffness evaluated by Doppler ultrasound in SSc patients with normal renal function. We also evaluated the correlation between serum UA and other clinical variables of the disease. METHODS: Forty-five SSc patients underwent clinical assessment, Doppler ultrasound of intrarenal arteries with evaluation of resistive index (RI), pulsatile index (PI), and systolic/diastolic ratio (S/D), echocardiography with systolic pulmonary artery pressure (PAPs), baseline pulmonary function tests, and nailfold videocapillaroscopy (NVC)...
July 2016: Microvascular Research
https://www.readbyqxmd.com/read/26995556/evaluation-of-nailfold-videocapillaroscopy-in-central-serous-chorioretinopathy
#15
Muhammet Kazim Erol, Ayse Balkarli, Devrim Toslak, Berna Dogan, Dogan Durmaz, Elçin Süren, Salih Altun, Mehmet Bulut, Veli Cobankara
BACKGROUND: Nailfold videocapillaroscopy (NVC) is a diagnostic tool to evaluate micro-vasculature. The presence of choroidal vasculopathy is apparent in central serous chorioretinopathy (CSCR). OBJECTIVES: This study was aimed at assessing capillaroscopic nailfold findings in patients with CSCR. To the best of our knowledge, there is no study assessing NVC findings in CSCR in the literature. METHOD: Sixty-one patients with CSCR who met the inclusion criteria, and 82 age- and sex-matched healthy controls were included to the study...
March 19, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/26976953/digital-ischaemia-during-cooling-is-independently-related-to-nailfold-capillaroscopic-pattern-in-patients-with-raynaud-s-phenomenon
#16
Anniek M van Roon, Andries J Smit, Arie M van Roon, Hendrika Bootsma, Douwe J Mulder
OBJECTIVE: The aim of the study was to assess the association between plethysmographically measured vasospasms during stepwise cooling and recovery, as an index for digital ischaemia, and nailfold capillaroscopic pattern (NCP) severity in patients with primary or secondary RP, including SSc. METHODS: In 381 consecutive patients with suspected RP without a history of digital ulcers, NCP (assessed by widefield videocapillaroscopy), fingertip photoelectric plethysmography during cooling and recovery and clinical characteristics were analysed...
June 2016: Rheumatology
https://www.readbyqxmd.com/read/26969104/dynamic-nailfold-videocapillaroscopy-may-be-used-for-early-detection-of-microvascular-dysfunction-in-obesity
#17
Priscila A Maranhão, Maria das Graças Coelho de Souza, Luiz Guilherme Kraemer-Aguiar, Eliete Bouskela
OBJECTIVES: It has been hypothesized that obesity is the primary cause of microvascular dysfunction (MD), which could be a pathway to increase blood pressure and decrease insulin sensitivity. Due to the high prevalence of this metabolic disorder in the world today, the aim of this study was to investigate which is the most appropriate videocapillaroscopic method, between nailfold and dorsal finger, to assess microvascular function in obese patients since both techniques are non-invasive and could be used for early detection as well as for follow-up...
July 2016: Microvascular Research
https://www.readbyqxmd.com/read/26940067/nailfold-videocapillaroscopy-in-healthy-children-and-adolescents-description-of-normal-patterns
#18
Daniela G P Piotto, Juliana Sekiyama, Cristiane Kayser, Mariana Yamada, Claudio A Len, Maria T Terreri
OBJECTIVES: to describe normal patterns of nailfold videocapillaroscopy (NVC) in healthy children and adolescents; to quantify the relationship between age and capillary dimensions, intercapillary distance and number of capillaries/mm; to evaluate the inter and intraobserver concordance. METHODS: Cross-sectional study including 100 healthy participants aged 5 to 18 years. Capillary dimensions (capillary loop length, capillary width and intercapillary distance) and number of capillaries/mm were evaluated in 900 capillaries using stereomicroscope under 100x magnification...
March 1, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/26932291/novel-ideas-the-increased-skin-viscoelasticity-a-possible-new-fifth-sign-for-the-very-early-diagnosis-of-systemic-sclerosis
#19
Hristo Dobrev
INTRODUCTION: Diagnosis of systemic sclerosis (SSc) at very early stage could allow starting an appropriate therapy and improving the patient outcome. Skin involvement is often the first non-Raynaud's phenomenon (RP) symptom. Its uncovering may play an important role for the initial diagnosis. OBJECTIVE: To introduce a simplified method for non-invasive evaluation of skin mechanical properties in patients with clinically evident or suspected SSc. MATERIAL AND METHODS: A total of 94 patients and 162 healthy subjects were studied...
2013: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/26932289/early-diagnostic-and-predictive-value-of-capillaroscopy-in-systemic-sclerosis
#20
Maurizio Cutolo, Carmen Pizzorni, Alberto Sulli, Vanessa Smith
Nailfold microvascular impairment represents an early feature of systemic sclerosis (SSc) and its progression through different patterns of capillary damage and their validated scoring, is evaluable by nailfold videocapillaroscopy (NVC) in a safe and reliable manner. The presence of specific morphological microvascular alterations at the NVC (i.e., presence of giant capillaries) is fundamental and mandatory for the early diagnosis of SSc, together with the presence of the Raynaud's phenomenon. Furthermore, a recent longitudinal study showed a dynamic transition of microvascular damage through different NVC patterns of microangiopathy in almost 50% of SSc patients and clinical symptoms progressed in accordance with the NVC morphologic changes in 60% of the SSc patients...
2013: Current Rheumatology Reviews
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