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Nailfold videocapillaroscopy

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https://www.readbyqxmd.com/read/29782426/nailfold-videocapillaroscopy-changes-are-associated-with-the-presence-and-severity-of-systemic-sclerosis-related-interstitial-lung-disease
#1
Joana Caetano, Filipe S Paula, Marta Amaral, Susana Oliveira, José D Alves
OBJECTIVE: The aim of this study was to evaluate the association of nailfold videocapillaroscopy (NVC) changes with the presence and severity of interstitial lung disease (ILD) in systemic sclerosis. METHODS: This was a cross-sectional analysis of 48 systemic sclerosis patients (21 patients with ILD). The NVC characteristics considered were capillary organization, capillary loss (CL), avascular areas, enlarged and giant capillaries, hemorrhages, abnormally shaped capillaries, edema, and intermittent flux...
May 19, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29761614/diagnostic-value-of-nailfold-videocapillaroscopy-in-systemic-sclerosis-secondary-pulmonary-arterial-hypertension-a-meta-analysis
#2
Zhongbin Xia, Guiping Wang, Huashi Xiao, Shanshan Guo, Ying Liu, Fanru Meng, Dan Liu, Guoqing Li, Liang Zong
BACKGROUND: Microvascular changes play a decisive role in systemic sclerosis (SSc) and occur early in the course of the disease. Pulmonary arterial hypertension (PAH) represents one of the main clinical expressions of the vascular changes in SSc, and the abnormal changes especially capillary density and capillary width are detectable at nailfold videocapillaroscopy (NVC). AIM: The aim of this meta-analysis was to investigate the differences in capillary nailfold changes in SSc patients with and without PAH, and to estimate the early diagnostic value of NVC in systemic sclerosis secondary pulmonary arterial hypertension (SSc-PAH)...
May 15, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29733400/acute-and-chronic-effects-of-two-different-intravenous-iloprost-regimens-in-systemic-sclerosis-a-pragmatic-non-randomized-trial
#3
Tommaso Schioppo, Annalisa Orenti, Patrizia Boracchi, Orazio De Lucia, Antonella Murgo, Francesca Ingegnoli
Objectives: I.v. iloprost (ILO) may be used in the treatment of refractory RP and digital ulcers. We aim to evaluate the acute and chronic effects of two different ILO regimens by power Doppler US (PDUS) and nailfold videocapillaroscopy. Methods: In this 3-month single-centre pragmatic non-randomized trial, 96 SSc patients were included and stratified according to ILO treatment as: no ILO (group A), ILO once monthly (group B) and ILO for five consecutive days (group C)...
May 3, 2018: Rheumatology
https://www.readbyqxmd.com/read/29730685/the-microvascular-and-morphostructural-changes-of-nails-in-psoriatic-patients-with-nail-disease-a-link-between-ultrasound-and-videocapillaroscopy-findings-in-the-nailfold
#4
Sibel Bakirci Ureyen, Rabia Oztas Kara, Zeynep Erturk, Mahizer Yaldiz
OBJECTIVE: The objective of this study is to evaluate the link between nail fold vessel resistive index (NVRI) measured by ultrasound (US) and capillary loops diameters measured using nailfold videocapillarascopy (NVC), and to assess the morphological appearance of the nail bed in patients with psoriatic nail disease (PND) as compared with healthy controls (HCs). MATERIAL AND METHODS: This study was conducted in patients with PND and HCs. General demographic data were collected and clinical assessments were performed for all subjects...
May 2, 2018: Medical Ultrasonography
https://www.readbyqxmd.com/read/29686318/microcirculation-and-biomarkers-in-patients-with-resistant-or-mild-to-moderate-hypertension-a-cross-sectional-study
#5
Camillo L C Junqueira, Maria Eliane C Magalhães, Andréa Araújo Brandão, Esmeralci Ferreira, Fátima Z G A Cyrino, Priscila A Maranhão, Maria das Graças C Souza, Daniel Alexandre Bottino, Eliete Bouskela
Microcirculation influences peripheral vascular resistance and therefore contributes to arterial blood pressure. The aim of this study was to investigate the correlation between serum markers of inflammation and microcirculatory parameters observed by nailfold videocapillaroscopy (NVC) in patients with resistant (RH, 58 [50-63] years, n = 25) or mild-to-moderate hypertension (MMH, 56 [47-64] years, n = 25) compared to normotensive patients (control group (CG), 33 [27-52] years, n = 25). C-reactive protein (CRP), endothelin, adiponectin, I-CAM and V-CAM levels were obtained by laboratory analysis...
April 23, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29537711/in-systemic-sclerosis-microvascular-and-hands-digital-arteries-damage-correlates-with-serum-levels-of-endostatin
#6
Antonietta Gigante, Luca Navarini, Domenico Margiotta, Biagio Barbano, Antonella Afeltra, Edoardo Rosato
OBJECTIVE: In SSc, vascular injury leads to endothelial dysfunction with reduced capillary blood flow and tissue hypoxia. In SSc, the angiogenesis is impaired and implicated in the microvascular damage. In severe vascular damage, VEGF is reduced and endostatin is increased. The aim of this study was to evaluate the correlation between endostatin serum levels and microvascular and digital arteries damage. METHODS: Seventeen patients with SSc were enrolled in this study...
May 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29527781/automated-assessment-of-absolute-nailfold-capillary-number-on-videocapillaroscopic-images-proof-of-principle-and-validation-in-systemic-sclerosis
#7
Maurizio Cutolo, Amelia C Trombetta, Karin Melsens, Carmen Pizzorni, Alberto Sulli, Barbara Ruaro, Sabrina Paolino, Ellen Deschepper, Vanessa Smith
BACKGROUND: Absolute nailfold capillary number should be a putative biomarker in selected rheumatic diseases but could be time-consuming and not highly repeatable. OBJECTIVE: To validate an automated software for absolute nailfold capillary number and density evaluation, on NVC images in SSc. METHODS: An automated software to count nailfold capillary number (AUTOCAPI) had been constructed, through an exploratory image set. Subsequently, application rules have been created to define the ROI in NVC images, through a training images set...
May 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29526628/the-role-of-capillaroscopy-and-thermography-in-the-assessment-and-management-of-raynaud-s-phenomenon
#8
REVIEW
Ariane L Herrick, Andrea Murray
Most patients with Raynaud's phenomenon (RP) have "benign" primary RP (PRP), but a minority have an underlying cause, for example a connective tissue disease such as systemic sclerosis (SSc). Secondary RP can be associated with structural as well as functional digital vascular changes and can be very severe, potentially progressing to digital ulceration or gangrene. The first step in management is to establish why the patient has RP. This short review discusses the role of nailfold capillaroscopy and thermography in the assessment of RP...
May 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29476351/can-nailfold-videocapillaroscopy-images-be-interpreted-reliably-by-different-observers-results-of-an-inter-reader-and-intra-reader-exercise-among-rheumatologists-with-different-experience-in-this-field
#9
Tatiana Sofía Rodriguez-Reyna, Chiara Bertolazzi, Angélica Vargas-Guerrero, Marwin Gutiérrez, Gabriela Hernández-Molina, Marcelo Audisio, Susana Roverano, Margarita González de Urizar, José Francisco Díaz Coto, Blanca Elizabeth Herrera Velasco, Mijahil Pavel Cornejo Ortega, Ana María Sapag Durán, Janeth Edelina Villegas Guzmán, Luís Fernando Medina Quintero, Mirtha Sabelli, Sandy Sapag Durán, Maurizio Cutolo
Nailfold videocapillaroscopy (VCP) allows non-invasive assessment of the microcirculation. Adequate training in this field is relevant for rheumatologists. There is increasing evidence of the reliability of VCP findings among different readers. OBJECTIVE: To evaluate inter- and intra-reader agreement of rheumatologists to identify normal images and systemic sclerosis (SSc) patterns on VCP ("early," "active," and "late" proposed by Cutolo et al.). Thirteen rheumatologists with different experience in nailfold VCP received training to standardize reading criteria...
February 23, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29451988/results-of-nailfold-capillaroscopy-in-patients-with-normal-tension-glaucoma
#10
Ewa Kosior-Jarecka, Joanna Bartosińska, Urszula Łukasik, Dominika Wróbel-Dudzińska, Dorota Krasowska, Grażyna Chodorowska, Tomasz Żarnowski
The aim of the study was to evaluate the results of nailfold videocapillaroscopic examination in patients with normal-tension glaucoma (NTG) in comparison to age-matched individuals without glaucoma and young healthy volunteers and to assess the relation between the results of this examination with clinical status in NTG group. MATERIAL AND METHODS: The studied group consisted of 188 patients: 80 patients with NTG and 2 control groups (58 young healthy and 50 age-matched volunteers). The nailfold videocapillaroscopy (NVC) was performed in all participants...
February 16, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29447411/the-assessment-of-nailfold-capillaries-comparison-of-dermoscopy-and-nailfold-videocapillaroscopy
#11
Graham Dinsdale, Sebastien Peytrignet, Tonia Moore, Michael Berks, Christopher Roberts, Joanne Manning, John Allen, Marina Anderson, Maurizio Cutolo, Roger Hesselstrand, Kevin Howell, Carmen Pizzorni, Vanessa Smith, Alberto Sulli, Marie Wildt, Christopher Taylor, Andrea Murray, Ariane L Herrick
No abstract text is available yet for this article.
February 13, 2018: Rheumatology
https://www.readbyqxmd.com/read/29409385/evidence-for-increase-in-finger-blood-flow-evaluated-by-laser-doppler-flowmetry-following-iloprost-infusion-in-patients-with-systemic-sclerosis-a-week-long-observational-longitudinal-study
#12
C Rotondo, M Nivuori, A Chialà, E Praino, M Matucci Cerinic, M Cutolo, G Lapadula, F Iannone
OBJECTIVES: Iloprost plays an important role in the treatment of Raynaud's phenomenon (RP), but has transient vasodilatory effects owing to its very short half-time. We aimed to evaluate short- and medium-term haemodynamic effects of iloprost by measuring dorsal finger microvessel blood flow using laser Doppler flowmetry (LDF), in patients with RP associated with systemic sclerosis (SSc). METHOD: In 24 consecutive SSc patients with RP (disease duration 10.5 ± 1...
February 7, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29320840/microvascular-damage-evaluation-in-systemic-sclerosis-the-role-of-nailfold-videocapillaroscopy-and-laser-techniques
#13
B Ruaro, A Sulli, V Smith, C Pizzorni, S Paolino, E Alessandri, M Cutolo
Microvascular damage and a decrease in peripheral blood perfusion are typical features of systemic sclerosis (SSc) with serious clinical implications, not only for a very early diagnosis, but also for disease progression. Nailfold videocapillaroscopy is a validated and safe imaging technique able to detect peripheral capillary morphology, as well as to classify and to score any nailfold abnormalities into different microangiopathy patterns. Capillaroscopic analysis is now included in the ACR/EULAR classification criteria for SSc...
December 21, 2017: Reumatismo
https://www.readbyqxmd.com/read/28894946/an-international-survey-on-non-invasive-techniques-to-assess-the-microcirculation-in-patients-with-raynaud-s-phenomenon-sunshine-survey
#14
Francesca Ingegnoli, Nicola Ughi, Graham Dinsdale, Annalisa Orenti, Patrizia Boracchi, Yannick Allanore, Ivan Foeldvari, Alberto Sulli, Maurizio Cutolo, Vanessa Smith, Ariane L Herrick
To canvas opinion concerning the role of non-invasive techniques in the assessment of patients with Raynaud's phenomenon (Rp) in clinical and research settings: four nailfold capillaroscopy methods [videocapillaroscopy (NVC), dermoscopy, stereomicroscopy, digital USB microscopy], four laser Doppler methods (laser Doppler flowmetry, imaging, anemometry/velocimetry, laser speckle contrast analysis), thermographic imaging, and upper limb arterial Doppler ultrasound. Emails with a link to the survey were sent to physicians from the European Scleroderma Trials and Research group (EUSTAR), the EULAR Study Group on Microcirculation in Rheumatic Diseases (SG_MC/RD) and members of the pediatric rheumatology Email board...
November 2017: Rheumatology International
https://www.readbyqxmd.com/read/28834709/correlations-between-blood-perfusion-and-dermal-thickness-in-different-skin-areas-of-systemic-sclerosis-patients
#15
B Ruaro, A Sulli, C Pizzorni, S Paolino, V Smith, E Alessandri, A C Trombetta, J Alsheyyab, M Cutolo
OBJECTIVE: To identify possible correlations between skin blood perfusion (BP) and dermal thickness (DT) in different skin areas of systemic sclerosis (SSc) patients. METHODS: Sixty-two SSc patients, according to 2013 EULAR/ACR criteria, and 62 healthy subjects (CNT) were enrolled. Skin BP was analysed by laser speckle contrast analysis (LASCA) at the level of dorsum of the middle phalanx of the third fingers, dorsal aspect of the hands and zygoma. DT was assessed by both skin high frequency ultrasound (US) and modified Rodnan skin score (mRSS) in the same above reported areas...
August 20, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28797111/angiogenic-t-cell-expansion-correlates-with-severity-of-peripheral-vascular-damage-in-systemic-sclerosis
#16
Mirko Manetti, Sara Pratesi, Eloisa Romano, Silvia Bellando-Randone, Irene Rosa, Serena Guiducci, Bianca Saveria Fioretto, Lidia Ibba-Manneschi, Enrico Maggi, Marco Matucci-Cerinic
The mechanisms underlying endothelial cell injury and defective vascular repair in systemic sclerosis (SSc) remain unclear. Since the recently discovered angiogenic T cells (Tang) may have an important role in the repair of damaged endothelium, this study aimed to analyze the Tang population in relation to disease-related peripheral vascular features in SSc patients. Tang (CD3+CD31+CXCR4+) were quantified by flow cytometry in peripheral blood samples from 39 SSc patients and 18 healthy controls (HC). Circulating levels of the CXCR4 ligand stromal cell-derived factor (SDF)-1α and proangiogenic factors were assessed in paired serum samples by immunoassay...
2017: PloS One
https://www.readbyqxmd.com/read/28619664/nailfold-capillaroscopic-changes-in-patients-with-idiopathic-pulmonary-arterial-hypertension-and-systemic-sclerosis-related-pulmonary-arterial-hypertension
#17
A Corrado, M Correale, N Mansueto, I Monaco, A Carriero, A Mele, R Colia, M Di Biase, F P Cantatore
Pulmonary arterial hypertension (PAH) represents one of the main clinical expressions of the vascular changes in systemic sclerosis (SSc). Lung microvascular changes can play a role in the pathogenesis of idiopathic PAH (IPAH) also. The aim of this study is to investigate the presence of capillaroscopic abnormalities in patients with IPAH and to evaluate the differences in capillary nailfold changes between patients with IPAH and patients with SSc with and without PAH. METHODS: 39 SSc patients (19 with PAH - SSc-PAH and 20 without - SSc-noPAH), 21 subjects with IPAH and 20 healthy subjects were recruited...
June 12, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28610600/the-cumulative-number-of-micro-haemorrhages-and-micro-thromboses-in-nailfold-videocapillaroscopy-is-a-good-indicator-of-disease-activity-in-systemic-sclerosis-a-validation-study-of-the-nemo-score
#18
Romina Andracco, Rosaria Irace, Eleonora Zaccara, Serena Vettori, Wanda Maglione, Antonella Riccardi, Francesca Pignataro, Roberta Ferrara, Domenico Sambataro, Gianluca Sambataro, Claudio Vitali, Gabriele Valentini, Nicoletta Del Papa
BACKGROUND: Some abnormalities in nailfold videocapillaroscopy (NVC), such as the presence of micro-haemorrhages (MHEs), micro-thromboses (MTs), giant capillaries (GCs) and reduction in the number of capillaries (nCs), suggest a disease activity (DA) phase in systemic sclerosis (SSc). In a previous paper, we showed that the number of micro-haemorrhages and micro-thromboses (the so-called NEMO score) was the NVC feature more closely associated with DA. The present study was aimed at validating the NEMO score as a measure of DA in patients with SSc...
June 13, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28602918/angiogenic-and-angiostatic-factors-in-renal-scleroderma-associated-vasculopathy
#19
Antonietta Gigante, Luca Navarini, Domenico Margiotta, Antonio Amoroso, Biagio Barbano, Rosario Cianci, Antonella Afeltra, Edoardo Rosato
BACKGROUND: The angiogenesis in systemic sclerosis (SSc) is impaired. An imbalance of pro-angiogenic factors and angiogenesis inhibitors has been implicated in the progression of peripheral microvascular damage, defective vascular repair and fibrosis. Intrarenal resistance index are considered markers of renal vasculopathy. The aim of the study is to evaluate angiogenic and angiostatic factors (VEGF and endostatin) in SSc patients and to correlate with intrarenal hemodynamic parameters...
June 8, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28598975/vitamin-d-deficiency-and-clinical-correlations-in-systemic-sclerosis-patients-a-retrospective-analysis-for-possible-future-developments
#20
Amelia Chiara Trombetta, Vanessa Smith, Emanuele Gotelli, Massimo Ghio, Sabrina Paolino, Carmen Pizzorni, Amber Vanhaecke, Barbara Ruaro, Alberto Sulli, Maurizio Cutolo
OBJECTIVE: Assessment of serum 25-hydroxyvitamin D (25(OH)D) correlations with clinical parameters and evaluation of the efficacy of standard oral supplementation in systemic sclerosis (SSc) patients. METHODS: 154 SSc patients were recruited, in all seasons. Serum 25(OH)D concentrations were evaluated using LIAISON 25-OH (Diasorin, Italy). Medsger disease severity scale (DSS), nailfold videocapillaroscopy (NVC) and all instrumental exam contemplated by international guidelines were performed...
2017: PloS One
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