keyword
https://read.qxmd.com/read/38530791/capi-score-a-quantitative-algorithm-for-identifying-disease-patterns-in-nailfold-videocapillaroscopy
#1
JOURNAL ARTICLE
B C Gracia Tello, L Sáez Comet, G Lledó, M Freire Dapena, M A Mesa, M Martín-Cascón, A Guillén Del Castillo, E Martínez Robles, C P Simeón-Aznar, J A Todolí Parra, D C Varela, G Maldonado Vélez, A Marín Ballvé, J Aramburu Llorente, L Pérez Abad, E Ramos Ibáñez
OBJECTIVES: The European Alliance of Associations for Rheumatology (EULAR) supports the use of nailfold videocapillaroscopy (NVC) to identify disease patterns (DPs) associated with systemic sclerosis (SSc) and Raynaud's phenomenon (RP). Recently, EULAR proposed an easy-to-manage procedure, a so-called Fast Track algorithm, to differentiate SSc from non-SSc patterns in NVC specimens. However, subjectivity among capillaroscopists remains a limitation. Our aim was to perform a software-based analysis of NVC peculiarities in a cohort of samples from SSc and RP patients and, subsequently, build a Fast Track-inspired algorithm to identify DPs without the constraint of interobserver variability...
March 26, 2024: Rheumatology
https://read.qxmd.com/read/38466107/ocular-involvement-in-systemic-sclerosis-updated-review-and-new-insights-on-microvascular-impairment
#2
REVIEW
Matteo Mario Carlà, Gloria Gambini, Tomaso Caporossi, Federico Giannuzzi, Francesco Boselli, Emanuele Crincoli, Matteo Ripa, Stanislao Rizzo
Systemic sclerosis (SSc) is a chronic multisystemic disease characterized by immunological activation, diffuse vasculopathy, and generalized fibrosis exhibiting a variety of symptoms. A recognized precursor of SSc is Raynaud's phenomenon, which is part of the very early disease of systemic sclerosis (VEDOSS) in combination with nailfold videocapillaroscopy (NVC) impairment. The pathophysiology of ocular involvement, alterations in internal organs, and body integumentary system involvement in SSc patients are complicated and poorly understood, with multiple mechanisms presumptively working together...
March 11, 2024: Ocular Immunology and Inflammation
https://read.qxmd.com/read/38465507/re-evaluation-of-nailfold-capillaroscopy-in-discriminating-primary-from-secondary-raynaud-s-phenomenon-and-in-predicting-systemic-sclerosis-a-randomised-observational-prospective-cohort-study
#3
JOURNAL ARTICLE
Marta C Amaral, F Seguro Paula, Joana Caetano, Paul Rj Ames, J Delgado Alves
BACKGROUND: Primary Raynaud's phenomenon (pRP) is difficult to distinguish from secondary (sRP). Although nailfold capillaroscopy (NFC) may detect early alterations, no universal criteria yet discriminate between pRP from sRP. OBJECTIVES: To create and validate two NFC scores that could distinguish pRP from sRP and that could predict systemic sclerosis (SSc), respectively. METHODS: We performed NFC on two separate cohorts with isolated RP, and recorded number of capillaries per field, enlarged/giant capillaries, crossed/bizarre patterns, microhemorrhages, neoangiogenesis, rarefaction, edema, blood flow velocity, stasis...
March 11, 2024: Expert Review of Clinical Immunology
https://read.qxmd.com/read/38333531/practice-pattern-for-the-use-of-intravenous-iloprost-for-the-treatment-of-peripheral-vasculopathy-in-systemic-sclerosis-a-case-control-study-from-the-italian-national-multicenter-spring-systemic-sclerosis-progression-investigation-registry
#4
JOURNAL ARTICLE
Valeria Riccieri, Greta Pellegrino, Edoardo Cipolletta, Dilia Giuggioli, Gianluigi Bajocchi, Silvia Bellando-Randone, Lorenzo Dagna, Giovanni Zanframundo, Rosario Foti, Fabio Cacciapaglia, Giovanna Cuomo, Alarico Ariani, Edoardo Rosato, Gemma Lepri, Francesco Girelli, Elisabetta Zanatta, Silvia Laura Bosello, Ilaria Cavazzana, Francesca Ingegnoli, Maria De Santis, Giuseppe Murdaca, Giuseppina Abignano, Nicoletta Romeo, Alessandra Della Rossa, Maurizio Caminiti, Annamaria Iuliano, Giovanni Ciano, Lorenzo Beretta, Gianluca Bagnato, Ennio Lubrano, Ilenia De Andres, Alessandro Giollo, Marta Saracco, Cecilia Agnes, Federica Lumetti, Amelia Spinella, Luca Magnani, Corrado Campochiaro, Giacomo De Luca, Veronica Codullo, Elisa Visalli, Claudio Di Vico, Antonietta Gigante, Francesca Saccon, Maria Grazia Lazzaroni, Franco Franceschini, Elena Generali, Gianna Mennillo, Simone Barsotti, Giuseppa Pagano Mariano, Francesca Calabrese, Federica Furini, Licia Vultaggio, Simone Parisi, Clara Lisa Peroni, Gerolamo Bianchi, Fabrizio Conti, Franco Cozzi, Salvatore D'Angelo, Andrea Doria, Enrico Fusaro, Marcello Govoni, Serena Guiducci, Florenzo Iannone, Carlo Salvarani, Gian Domenico Sebastiani, Clodoveo Ferri, Marco Matucci-Cerinic, Rossella De Angelis
BACKGROUND: Intravenous iloprost has been widely used for the treatment of systemic sclerosis peripheral vasculopathy. No agreement has been found on the regimen and the dosage of intravenous iloprost in different scleroderma subset conditions. This study aimed to evaluate the modalities of intravenous iloprost administration within a large cohort of systemic sclerosis patients from the SPRING Registry and to identify any associated clinical-demographic, instrumental or therapeutic data...
February 2024: Journal of Scleroderma and related Disorders
https://read.qxmd.com/read/38282194/chronic-spontaneous-urticaria-evidence-of-systemic-microcirculatory-changes
#5
JOURNAL ARTICLE
Yora Mostmans, Marcus Maurer, Bertrand Richert, Vanessa Smith, Karin Melsens, Viviane De Maertelaer, Ines Saidi, Francis Corazza, Olivier Michel
BACKGROUND: Chronic spontaneous urticaria (CSU) is a chronic inflammatory skin disease where activation of endothelial cells (ECs) at sites of skin lesions leads to increased blood flow, leakage of fluid into the skin, cellular infiltration, and vascular remodeling. To understand the disease duration and the sometimes vague systemic symptoms accompanying flares, the objective of this study was to examine if CSU comes with systemic vascular changes at the microcirculatory level. METHODS: We investigated CSU patients (n = 49) and healthy controls (HCs, n = 44) for microcirculatory differences by nailfold videocapillaroscopy (NVC) and for blood levels of the soluble EC biomarkers serum vascular endothelial growth factor (VEGF), soluble E-selectin, and stem cell factor (SCF)...
January 2024: Clinical and Translational Allergy
https://read.qxmd.com/read/38190091/microvascular-status-in-juvenile-sj%C3%A3-gren-s-disease-the-first-nailfold-videocapillaroscopy-investigation
#6
JOURNAL ARTICLE
Adriano Lercara, Clara Malattia, Elvis Hysa, Marco Gattorno, Andrea Cere, Claudio Lavarello, Tamara Vojinovic, Emanuele Gotelli, Sabrina Paolino, Alberto Sulli, Carmen Pizzorni, Vanessa Smith, Maurizio Cutolo
INTRODUCTION: Juvenile Sjögren's disease (jSjD) is a rare autoimmune disease characterized by exocrine gland involvement and systemic manifestations, including small vessel vasculitis and Raynaud's phenomenon (RP). We aimed to investigate the microvascular status in jSjD patients by nailfold videocapillaroscopy (NVC) and the potential correlations with clinical and serological features. METHODS: Clinical data from thirteen consecutive jSjD patients (11 females and 2 males), with a mean age of 16 ± 4 years, diagnosed before 16 years of age (mean age at diagnosis 12 ± 3) according to the 2016 American College of Rheumatology/EULAR criteria for adult SjD, were collected including age- and sex-matched healthy controls (HCs)...
January 8, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38167073/nailfold-videocapillaroscopy-in-antineutrophil-cytoplasmic-antibody-associated-vasculitis
#7
JOURNAL ARTICLE
Megan M Sullivan, Andy Abril, Nabeel Aslam, Colleen T Ball, Florentina Berianu
OBJECTIVE: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of illnesses that cause inflammation and alterations to small vessels in the body. Some of the most common and detrimental manifestations, including alveolar hemorrhage and glomerulonephritis, are caused by this capillary inflammation. We sought to clarify whether patients with AAV would have abnormal nailfold capillaries when evaluated with nailfold videocapillaroscopy. METHODS: Patients with a current diagnosis of AAV and a control group were identified for enrollment...
January 2, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38131558/proximal-nailfold-videocapillaroscopy-findings-of-patients-with-idiopathic-macular-telangiectasia-type-2
#8
JOURNAL ARTICLE
Birumut Gedik, Muhammet K Erol, Mehmet Bulut, Berna Dogan, Yigit C Bozdogan, Rojbin Ekinci, Ayse Ayan
PURPOSE: Idiopathic macular telangiectasia type 2 (IMT) is a neurodegenerative disease characterized by bilateral, idiopathic, and perifoveal retinal telangiectatic vessel formations. We aimed to compare proximal nailfold videocapillaroscopy (NV) findings between patients with IMT and healthy individuals and evaluate the optical coherence tomography angiography (OCTA) parameters of the patients with IMT according to their NV findings. METHODS: The study included 43 patients with IMT and 92 healthy controls of similar age and gender without any additional diseases...
January 1, 2024: Indian Journal of Ophthalmology
https://read.qxmd.com/read/37978075/peripheral-and-ocular-microvascular-alterations-in-systemic-sclerosis-observations-from-capillaroscopic-assessments-perfusion-peripheral-analysis-and-optical-coherence-tomography-angiography
#9
JOURNAL ARTICLE
Carlo Alberto Cutolo, Andrea Cere, Paola Toma, Tommaso Cannavacciuolo, Chiara Toma, Serena Balito, Veronica Gerli, Vanessa Smith, Alberto Sulli, Sabrina Paolino, Emanuele Gotelli, Carlo Enrico Traverso, Massimo Nicolò, Maurizio Cutolo, Elvis Hysa
To investigate the correlations between finger microvascular morphology and function in patients with systemic sclerosis (SSc) and the status of ocular microcirculation, as detected by nailfold videocapillaroscopy (NVC), laser speckle contrast analysis (LASCA), and optical coherence tomography angiography (OCTA). The enrollment included 32 SSc patients, classified according to the 2013 ACR/EULAR criteria, and 27 sex- and age-matched healthy controls. The participants underwent comprehensive rheumatological and ophthalmological examinations, as well as NVC, LASCA, and OCTA analysis on the same day at a single center from March to October 2022...
November 17, 2023: Rheumatology International
https://read.qxmd.com/read/37976114/microvascular-status-and-skin-thickness-in-adults-with-hypermobile-ehlers-danlos-syndrome-a-pilot-investigation
#10
JOURNAL ARTICLE
Alberto Sulli, Elvis Hysa, Andrea Cere, Francesca Lalli, Alessandro Pinelli, Silvia Sammorì, Emanuele Gotelli, Carmen Pizzorni, Fransiska Malfait, Marco Castori, Vanessa Smith, Maurizio Cutolo
OBJECTIVES: Hypermobile Ehlers-Danlos Syndrome (hEDS) is a hereditary connective tissue disorder characterised by joint hypermobility, chronic musculoskeletal pain, and skin abnormalities and easy bruising. Morphological and functional microvascular status has not yet been studied in hEDS, and dermal thickness (DT) has been poorly investigated, therefore the aim of our study was to investigate it. METHODS: We conducted a study to investigate microvascular morphology by nailfold videocapillaroscopy (NVC), peripheral blood perfusion (PBP) by laser speckle contrast analysis (LASCA), and DT by high-frequency skin ultrasound (22 MHz probe) in adults with hEDS compared to sex- and age-matched controls...
November 8, 2023: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/37948719/microcirculatory-alterations-in-stable-coronary-artery-disease-patients-with-concomitant-covid-19
#11
JOURNAL ARTICLE
Vasyl Z Netiazhenko, Serhii I Mostovyi, Olga M Safonova, Kyrylo O Mikhaliev
OBJECTIVE: The aim: To evaluate the alterations in microcirculation of stable coronary artery disease (SCAD) patients with concomitant COVID-19. PATIENTS AND METHODS: Materials and methods: The cross-sectional study analyzed the data from 80 patients, being subdivided as follows: group 1 (G1) - SCAD without COVID-19 (n=30); group 2 (G2) - SCAD with concomitant COVID-19 (n=25); group 3 (G3) - COVID-19 without SCAD (n=25). The control group included 30 relatively healthy volunteers...
2023: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://read.qxmd.com/read/37624917/significant-nailfold-capillary-loss-and-late-capillaroscopic-pattern-are-associated-with-pulmonary-arterial-hypertension-in-systemic-sclerosis
#12
JOURNAL ARTICLE
Rossella De Angelis, Valeria Riccieri, Edoardo Cipolletta, Nicoletta Del Papa, Francesca Ingegnoli, Silvia Bosello, Amelia Spinella, Greta Pellegrino, Marco de Pinto, Silvia Papa, Giuseppe Armentaro, Dilia Giuggioli
OBJECTIVES: To evaluate differences in nailfold videocapillaroscopy (NVC) findings between systemic sclerosis-SSc patients with and without a diagnosis of pulmonary arterial hypertension (PAH). METHODS: 110 SSc patients were enrolled in this cross-sectional, case-control, multi-centre study. Patients were divided into cases (SSc-PAH confirmed by right hearth catheterization-RHC) and controls (SSc-nonPAH with low probability of PAH). NVC patterns (early, active, and late) and morphological parameters (microvascular density, non-specific abnormalities, giant capillaries, micro-haemorrhages, avascular areas) were considered using a semiquantitative scoring system...
August 25, 2023: Rheumatology
https://read.qxmd.com/read/37534953/nailfold-videocapillaroscopy-patterns-in-systemic-sclerosis-implications-for-cutaneous-subsets-disease-features-and-prognostic-value-for-survival
#13
JOURNAL ARTICLE
Carles Tolosa-Vilella, Maria Del Mar Rodero-Roldán, Alfredo Guillen-Del-Castillo, Adela Marín-Ballvé, Rafael Boldova-Aguar, Begoña Marí-Alfonso, Carlos Feijoo-Massó, Dolores Colunga-Argüelles, Manuel Rubio-Rivas, Luis Trapiella-Martínez, Nerea Iniesta-Arandia, Eduardo Callejas-Moraga, Francisco J García-Hernández, Luis Sáez-Comet, Cristina González-Echávarri, Norberto Ortego-Centeno, Mayka Freire, Jose Antonio Vargas-Hitos, Juan J Ríos-Blanco, Jose Antonio Todolí-Parra, Ignasi Rodríguez-Pintó, Antonio-J Chamorro, Xavier Pla-Salas, Ana Belén Madroñero-Vuelta, Manuel Ruiz-Muñoz, Vicent Fonollosa-Pla, Carmen Pilar Simeón-Aznar
OBJECTIVES: To assess the associations and prognostic value of scleroderma patterns by nailfold videocapillaroscopy (NVC) in patients with systemic sclerosis (SSc) and cutaneous subsets. METHODS: At baseline, 1356 SSc patients from the RESCLE registry were compared according to the scleroderma pattern as Late pattern and non-Late pattern, which included Early and Active patterns. Patient characteristics, disease features, survival time and causes of death were analysed...
August 2023: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/37525698/towards-early-diagnosis-of-mixed-connective-tissue-disease-updated-perspectives
#14
REVIEW
Chiara Alfia Ferrara, Gaetano La Rocca, Giuseppe Ielo, Alessandro Libra, Gianluca Sambataro
Mixed Connective Tissue Disease (MCTD) is an autoimmune disease first described by Sharp et al in 1972, characterized by the presence of anti-Ribonucleoprotein antibodies directed against the U1 complex (anti-U1RNP). The condition shares clinical characteristics with Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Systemic Sclerosis. Diagnosis is quite difficult due to its rarity, the lack of validated classification criteria, and its heterogeneous clinical presentation. While in the early stages its nuanced clinical features might lead to it being incorrectly classified as other Connective Tissue Diseases (CTDs) or even not recognized, in cases of longstanding disease its classification as a CTD is clear but challenging to discriminate from overlap syndromes...
2023: ImmunoTargets and Therapy
https://read.qxmd.com/read/37510932/comparison-of-nailfold-videocapillaroscopy-with-retinal-and-choroidal-vascular-parameters-in-patients-with-central-serous-chorioretinopathy
#15
JOURNAL ARTICLE
Małgorzata Latalska, Joanna Bartosińska, Sławomir Dresler, Mario Damiano Toro, Dorota Krasowska, Robert Rejdak
AIM: This study seeks to evaluate the results of nailfold videocapillaroscopies (NVCs) among patients with central serous chorioretinopathy (CSC) and their correlation with the choroid and retinal parameters. MATERIAL AND METHODS: The examined group included 152 patients with acute, recurrent, chronic and neovascular CSC (34 F, 118 M, mean age 45.9 ± 8.9) and 41 healthy controls (12 F, 29 M, mean age 47 ± 11.5). The NVC examination, ophthalmoscopy, angio-OCT and OCT were performed...
July 21, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37451812/microvascular-damage-in-autoimmune-connective-tissue-diseases-a-capillaroscopic-analysis-from-20-years-of-experience-in-a-eular-training-and-research-referral-centre-for-imaging
#16
JOURNAL ARTICLE
Elvis Hysa, Carmen Pizzorni, Silvia Sammorì, Emanuele Gotelli, Andrea Cere, Carlotta Schenone, Giorgia Ferrari, Rosanna Campitiello, Veronica Gerli, Sabrina Paolino, Alberto Sulli, Vanessa Smith, Maurizio Cutolo
OBJECTIVE: Nailfold videocapillaroscopy (NVC) allows the detection of microvascular damage in autoimmune connective tissue diseases (CTDs). The prevalence of the morphological capillary findings was retrospectively evaluated in a wide cohort of patients with Raynaud's phenomenon secondary to a CTD at the time of the first single NVC, independently from their current treatment, autoantibody profile and comorbidities. METHODS: One-thousand-one-hundred-eighty-one patients affected by CTDs were included from 2001 to 2021...
July 2023: RMD Open
https://read.qxmd.com/read/37443598/methods-of-assessing-nailfold-capillaroscopy-compared-to-video-capillaroscopy-in-patients-with-systemic-sclerosis-a-critical-review-of-the-literature
#17
REVIEW
Zechen Ma, Douwe Johannes Mulder, Robert Gniadecki, Jan Willem Cohen Tervaert, Mohammed Osman
INTRODUCTION: Nailfolds of patients with systemic sclerosis (SSc) provide an opportunity to directly visualize microvascular remodeling in SSc. Nailfold video capillaroscopy (NVC) remains the gold standard for assessing nailfold capillaroscopy (NFC). However, access to NVC is limited by expense and expertise. This review aims to synthesize current research on other NFC devices compared to NVC. METHODS: The literature search included the primary research of adult patients with SSc as defined by the 2013 ACR/EULAR criteria...
June 28, 2023: Diagnostics
https://read.qxmd.com/read/37419757/nailfold-capillaroscopy
#18
REVIEW
Vanessa Smith, Claudia Ickinger, Elvis Hysa, Marcus Snow, Tracy Frech, Alberto Sulli, Maurizio Cutolo
Nailfold capillaroscopy is a safe and well-established method for the assessment of structural alterations of the microcirculation. It is a crucial tool in the investigation and monitoring of patients presenting with Raynaud's phenomenon. Detection of the characteristic "scleroderma pattern" on capillaroscopy may indicate an underlying rheumatic disease, particularly systemic sclerosis (SSc). Herein, we highlight the practical aspects of videocapillaroscopy, including image acquisition and analysis, with mention of dermoscopy...
July 5, 2023: Best Practice & Research. Clinical Rheumatology
https://read.qxmd.com/read/37414357/peripheral-nailfold-capillary-microscopic-abnormalities-in-rheumatoid-arthritis-are-associated-with-arterial-stiffness-results-from-a-cross-sectional-study
#19
JOURNAL ARTICLE
Elena Angeloudi, Panagiota Anyfanti, Athanasia Dara, Eleni Pagkopoulou, Eleni Bekiari, Vasiliki Sgouropoulou, Alexandros Garyfallos, Michael Doumas, George D Kitas, Theodoros Dimitroulas
Vascular injury eventually resulting in the establishment of cardiovascular disease is a serious complication in rheumatoid arthritis (RA). Nailfold videocapillaroscopy (NVC) is a non-invasive imaging modality that enables the quantitative and qualitative assessment of the peripheral microvasculature. Nevertheless, capillaroscopic patterns remain inadequately defined in RA, especially regarding their clinical significance as potential markers of systemic vascular impairment. Consecutive RA patients underwent NVC using a standardized protocol, to assess the following parameters: capillary density, avascular areas, capillary dimensions, microhemorrhages, subpapillary venous plexus, and presence of ramified, bushy, crossed and tortuous capillaries...
July 4, 2023: Microvascular Research
https://read.qxmd.com/read/37370974/nailfold-videocapillaroscopy-in-patients-with-rheumatoid-arthritis-and-psoriatic-arthropathy-on-anti-tnf-alpha-therapy
#20
JOURNAL ARTICLE
Daniela Anghel, Carmen Adella Sîrbu, Oana-Georgiana Petrache, Daniela Opriș-Belinski, Maria Magdalena Negru, Violeta-Claudia Bojincă, Cristina Florentina Pleșa, Florentina Ioniță Radu
Videocapillaroscopy is a simple, non-invasive investigation that allows the "in vivo" study of the nailfold capillaries. This method is inexpensive, easily accepted by patients and the results can be easily interpreted. It is mainly used in patients with Raynaud's phenomenon and systemic sclerosis, but this examination can also be performed on patients who are suspected of having microcirculation alterations, such as rheumatoid arthritis and psoriatic arthritis. It may aid in the diagnosis, evaluation and prognosis of other rheumatic diseases, besides systemic sclerosis...
June 15, 2023: Diagnostics
keyword
keyword
102825
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.