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https://www.readbyqxmd.com/read/28106907/subsequent-malignancies-among-long-term-survivors-of-hodgkin-lymphoma-and-non-hodgkin-lymphoma-a-pooled-analysis-of-german-cancer-registry-data-1990-2012
#1
Nadia Baras, Stefan Dahm, Jörg Haberland, Martin Janz, Katharina Emrich, Klaus Kraywinkel, Abdulgabar Salama
The increased risk of subsequent primary malignancies (SPM) in survivors of adult-onset Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) remains a challenging clinical problem worldwide. The German cancer registry database, pooled from 14 federal states, was used to calculate the standardized incidence ratio (SIR) and excess absolute risk (EAR) of SPM in 128 587 patients registered with first primary HL/NHL between 1990 and 2012. Conversely, SIRs were also calculated for a subsequent HL/NHL following other first cancers...
January 20, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28072456/systemic-inflammatory-markers-and-outcome-in-patients-with-locally-advanced-adenocarcinoma-of-the-oesophagus-and-gastro-oesophageal-junction
#2
V P Jagadesham, S M Lagarde, A Immanuel, S M Griffin
BACKGROUND: Raised levels of systemic inflammatory markers are associated with poor survival in patients with cancer. The aim of this study was to assess the prognostic value of markers of systemic inflammation in patients with adenocarcinoma of the oesophagus or gastro-oesophageal junction. METHODS: Data from a consecutive series of patients undergoing transthoracic oesophagectomy following neoadjuvant therapy at a single centre were analysed. Fibrinogen, albumin, C-reactive protein, leucocyte differential and platelet counts were measured before surgery...
January 10, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28058012/evolving-management-of-metaplasia-and-dysplasia-in-barrett-s-epithelium
#3
REVIEW
Richard P T Evans, Moustafa Mabrouk Mourad, Simon G Fisher, Simon R Bramhall
Oesophageal cancer affects more than 450000 people worldwide and despite continued medical advancements the incidence of oesophageal cancer is increasing. Oesophageal cancer has a 5 year survival of 15%-25% and now globally attempts are made to more aggressively diagnose and treat Barrett's oesophagus the known precursor to invasive disease. Currently diagnosis the of Barrett's oesophagus is predominantly made after endoscopic visualisation and histopathological confirmation. Minimally invasive techniques are being developed to improve the viability of screening programs...
December 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28053340/population-screening-and-treatment-of-helicobacter-pylori-infection
#4
REVIEW
Anthony O'Connor, Colm A O'Morain, Alexander C Ford
Helicobacter pylori is an important human pathogen, associated with a substantial burden from both malignant and non-malignant diseases. The bacterium is classed as a human carcinogen, being strongly linked with gastric cancer, the third most common cause of cancer death worldwide and is also associated with common conditions such as dyspepsia and peptic ulcer. Eradication of H. pylori reduces the incidence of gastric cancer and peptic ulcer, as well as the prevalence and costs of managing dyspepsia. Economic analyses suggest that eradication of H...
January 5, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28053055/cancer-incidence-and-mortality-risks-in-a-large-us-barrett-s-oesophagus-cohort
#5
Michael B Cook, Sally B Coburn, Jameson R Lam, Philip R Taylor, Jennifer L Schneider, Douglas A Corley
OBJECTIVE: Barrett's oesophagus (BE) increases the risk of oesophageal adenocarcinoma by 10-55 times that of the general population, but no community-based cancer-specific incidence and cause-specific mortality risk estimates exist for large cohorts in the USA. DESIGN: Within Kaiser Permanente Northern California (KPNC), we identified patients with BE diagnosed during 1995-2012. KPNC cancer registry and mortality files were used to estimate standardised incidence ratios (SIR), standardised mortality ratios (SMR) and excess absolute risks...
January 4, 2017: Gut
https://www.readbyqxmd.com/read/28052061/integrated-genomic-characterization-of-oesophageal-carcinoma
#6
(no author information available yet)
Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and Eastern populations. Beyond known histopathological and epidemiologic distinctions, molecular features differentiated oesophageal squamous cell carcinomas from oesophageal adenocarcinomas. Oesophageal squamous cell carcinomas resembled squamous carcinomas of other organs more than they did oesophageal adenocarcinomas...
January 4, 2017: Nature
https://www.readbyqxmd.com/read/28027900/amorphous-aggregate-adducts-of-linker-histone-h1-turn-highly-immunologic-in-the-cancers-of-oesophagus-stomach-gall-bladder-and-ovary
#7
Abdul Rouf Mir, Moinuddin, Safia Habib
Hyperglycaemic influence on carcinogenesis and tumour progression is emerging as a link between diabetes and cancer. This work establishes the disturbed structural integrity of nucleosomal linker histone H1 by methyglyoxal (MG) and then correlates the role of modified H1 in the auto-immunopathogenesis of multiple cancers. MG modification caused a loss of free ε-amino groups in H1 and raised its β-sheet structural component with a consequence of non amyloid aggregation. It changed the folding-unfolding denaturation pattern of H1 and attached itself to the lysine residues of the protein eventually making up N(ε)-(carboxyethyl) lysine...
December 24, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28019086/the-risk-of-secondary-cancer-in-nasopharyngeal-carcinoma-paediatric-patients-due-to-intensity-modulated-radiotherapy-and-mega-voltage-cone-beam-computed-tomography
#8
Reham S Sherif, Ehab M Attalla, Wael M Elshemey, Noha G Madian
INTRODUCTION: There is a growing interest in the study of radiation-induced secondary cancer. The aim of this work is (i) to estimate the peripheral doses attributable to intensity modulated radiotherapy (IMRT) and mega-voltage cone beam computed tomography (MV-CBCT) for some organs at risk (OARs) which surround the target being treated (Nasopharynx) in paediatric patients. (ii) To estimate the risk of radiation-induced secondary cancers attributable to patient setup verification imaging dose using MV-CBCT for Nasopharyngeal Carcinoma (NPC) in paediatric patients and comparing it with that attributable to the therapeutic dose using IMRT...
December 25, 2016: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/27938785/review-surveillance-of-patients-with-barrett-oesophagus
#9
REVIEW
Sielte Maes, Prateek Sharma, Raf Bisschops
There has been a rapid increase in the incidence of oesophageal adenocarcinoma in most Western countries over the past thirty years. Barrett's oesophagus (BE) is a common premalignant lesion of oesophageal adenocarcinoma, although the risk of developing cancer in BE remains low. Therefore, screening is not recommended in the general population. Surveillance of BE is recommended to detect high grade dysplasia or carcinoma in an early stage, although there is no clear evidence that surveillance leads to a reduced mortality...
December 2016: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/27938783/cost-effectiveness-of-surveillance-for-gi-cancers
#10
REVIEW
Amir-Houshang Omidvari, Reinier G S Meester, Iris Lansdorp-Vogelaar
Gastrointestinal (GI) diseases are among the leading causes of death in the world. To reduce the burden of GI diseases, surveillance is recommended for some diseases, including for patients with inflammatory bowel diseases, Barrett's oesophagus, precancerous gastric lesions, colorectal adenoma, and pancreatic neoplasms. This review aims to provide an overview of the evidence on cost-effectiveness of surveillance of individuals with GI conditions predisposing them to cancer, specifically focussing on the aforementioned conditions...
December 2016: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/27927666/epigenetic-biomarkers-in-progression-from-non-dysplastic-barrett-s-oesophagus-to-oesophageal-adenocarcinoma-a-systematic-review-protocol
#11
T Nieto, C L Tomlinson, J Dretzke, S Bayliss, M Dilworth, A D Beggs, O Tucker
INTRODUCTION: Barrett's oesophagus (BO), a metaplastic condition affecting the lower oesophagus due to long-standing gastro-oesophageal reflux and chronic inflammation, is a precursor lesion for oesophageal adenocarcinoma (OADC). There is no clinical test to predict which patients with BO will progress to OADC. The British Society of Gastroenterology recommends endoscopic surveillance of patients with BO. Epigenetic changes have been well characterised in the neoplastic progression of ulcerative colitis to colonic carcinoma, another gastrointestinal cancer associated with chronic inflammation...
December 7, 2016: BMJ Open
https://www.readbyqxmd.com/read/27920642/recurrent-complete-pharyngo-oesophageal-stricture-treated-by-multidisciplinary-anterograde-retrograde-endoscopic-dilation
#12
Paulo Castro Soares, Salim Bouayed, Pavel Dulguerov, Jean-Louis Frossard
Complete pharyngo-oesophageal stricture (PES) after radiotherapy for head and neck cancer is a relatively rare and difficult complication to manage. Historically this condition has been treated surgically, but endoscopic approaches are now available. We present a 61-year-old man with an epidermoid carcinoma of the supraglottic stage and a micro-invasive epidermoid carcinoma of the oropharynx treated surgically and subsequently by adjuvant radiotherapy. Eight months after the end of the radiotherapy, a complete PES was diagnosed and treated with a combined anterograde-retrograde endoscopic dilation (CARD)...
September 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/27902130/cytosponge-test-could-be-an-alternative-to-endoscopy
#13
(no author information available yet)
A 'sponge on a string' pill test can identify people with Barrett's oesophagus who are at low risk of developing oesophageal cancer, say University of Cambridge researchers.
November 30, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27888615/unconjugated-secondary-bile-acids-activate-the-unfolded-protein-response-and-induce-golgi-fragmentation-via-a-src-kinase-dependant-mechanism
#14
Ruchika Sharma, Francis Quilty, John F Gilmer, Aideen Long, Anne-Marie Byrne
Bile acids are components of gastro-duodenal refluxate and regarded as causative agents in oesophageal disease but the precise mechanisms are unknown. Here we demonstrate that a specific subset of physiological bile acids affect the protein secretory pathway by inducing ER stress, activating the Unfolded Protein Response (UPR) and causing disassembly of the Golgi apparatus in oesophageal cells. Deoxycholic acid (DCA), Chemodeoxycholic acid (CDCA) and Lithocholic acid (LCA) activated the PERK arm of the UPR, via phosphorylation of eIF2α and up-regulation of ATF3, CHOP and BiP/GRP78...
November 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27870056/cure-of-cancer-for-seven-cancer-sites-in-the-flemish-region
#15
Geert Silversmit, David Jegou, Evelien Vaes, Elke Van Hoof, Els Goetghebeur, Liesbet Van Eycken
Cumulative relative survival curves for many cancers reach a plateau several years after diagnosis, indicating that the cancer survivor group has reached "statistical" cure. Parametric mixture cure model analysis on grouped relative survival curves provide an interesting way to determine the proportion of statistically cured cases and the mean survival time of the fatal cases in particular for population-based cancer registries. Based on the relative survival data from the Belgian Cancer Registry, parametric cure models were applied to seven cancer sites (cervix, colon, corpus uteri, skin melanoma, pancreas, stomach and oesophagus), at the Flemish Regional level for the incidence period 1999-2011...
March 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27842506/is-alcohol-consumption-a-risk-factor-for-prostate-cancer-a-systematic-review-and-meta-analysis
#16
Jinhui Zhao, Tim Stockwell, Audra Roemer, Tanya Chikritzhs
BACKGROUND: Research on a possible causal association between alcohol consumption and risk of prostate cancer is inconclusive. Recent studies on associations between alcohol consumption and other health outcomes suggest these are influenced by drinker misclassification errors and other study quality characteristics. The influence of these factors on estimates of the relationship between alcohol consumption and prostate cancer has not been previously investigated. METHODS: PubMed and Web of Science searches were made for case-control and cohort studies of alcohol consumption and prostate cancer morbidity and mortality (ICD-10: C61) up to December 2014...
November 15, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27829946/double-stenting-for-malignant-oesophago-respiratory-fistula
#17
Janusz Włodarczyk, Jarosław Kużdżał
INTRODUCTION: The close anatomical relationship between the oesophagus and bronchial tree results in formation of an oesophago-respiratory fistula in a subset of patients with advanced oesophageal or lung cancer. In those patients stenting of both the oesophagus and tracheobronchial tree is a valid option of palliative treatment. AIM: To determine the effectiveness, tolerance, quality of life, safety and survival after double stenting procedures. MATERIAL AND METHODS: Retrospective analysis of a prospectively collected database was performed, concerning consecutive patients with oesophago-respiratory fistulas treated with double stenting...
2016: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/27816465/european-code-against-cancer-4th-edition-alcohol-drinking-and-cancer
#18
Chiara Scoccianti, Michele Cecchini, Annie S Anderson, Franco Berrino, Marie-Christine Boutron-Ruault, Carolina Espina, Timothy J Key, Michael Leitzmann, Teresa Norat, Hilary Powers, Martin Wiseman, Isabelle Romieu
Alcohol consumption is the third leading risk factor for disease and mortality in Europe. As evaluated by the International Agency for Research on Cancer (IARC) Monographs, a causal relationship is established for consumption of alcoholic beverages and cancers of the oral cavity, pharynx, larynx, oesophagus, liver, colorectum and female breast, even at low and moderate alcohol intakes. The higher the amount of alcohol consumed, the higher the risk of developing cancer. In Europe, an estimated 10% (95% CI: 7%-13%) of all cancer cases in men and 3% (95% CI: 1%-5%) of all cancer cases in women are attributable to alcohol consumption...
December 2016: Cancer Epidemiology
https://www.readbyqxmd.com/read/27813082/cancer-risks-in-nairobi-2000-2014-by-ethnic-group
#19
Anne Korir, Emma Yu Wang, Peter Sasieni, Nathan Okerosi, Victor Ronoh, D Maxwell Parkin
We investigated the ethnic differences in the risk of several cancers in the population of Nairobi, Kenya, using data from the Nairobi Cancer Registry. The registry records the variable "Tribe" for each case, a categorisation that includes, as well as 22 tribal groups, categories for Kenyans of European and of Asian origin, and non-Kenyan Africans. Tribes included in the final analysis were Kikuyu, Kamba, Kisii, Kalenjin, Luo, Luhya, Somalis, Asians, non-Kenyans, Caucasians, Other tribes and unknown. The largest group was taken as the reference category for the calculation of odds ratios; this was African Kenyans (for comparisons by race), and Kikuyus (the tribe with the largest numbers of cancer registrations (38% of the total)) for comparisons between the Kenyan tribes...
February 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27812016/circulating-vitamin-d-in-relation-to-cancer-incidence-and-survival-of-the-head-and-neck-and-oesophagus-in-the-epic-cohort
#20
Anouar Fanidi, David C Muller, Øivind Midttun, Per Magne Ueland, Stein Emil Vollset, Caroline Relton, Paolo Vineis, Elisabete Weiderpass, Guri Skeie, Magritt Brustad, Domenico Palli, Rosario Tumino, Sara Grioni, Carlotta Sacerdote, H B As Bueno-de-Mesquita, Petra H Peeters, Marie-Christine Boutron-Ruault, Marina Kvaskoff, Claire Cadeau, José María Huerta, Maria-José Sánchez, Antonio Agudo, Cristina Lasheras, J Ramón Quirós, Saioa Chamosa, Elio Riboli, Ruth C Travis, Heather Ward, Neil Murphy, Kay-Tee Khaw, Antonia Trichopoulou, Pagona Lagiou, Eleni-Maria Papatesta, Heiner Boeing, Tilman Kuehn, Verena Katzke, Annika Steffen, Anders Johansson, Paul Brennan, Mattias Johansson
Experimental and epidemiological data suggest that vitamin D play a role in pathogenesis and progression of cancer, but prospective data on head and neck cancer (HNC) and oesophagus cancer are limited. The European Prospective Investigation into Cancer and Nutrition (EPIC) study recruited 385,747 participants with blood samples between 1992 and 2000. This analysis includes 497 case-control pairs of the head and neck and oesophagus, as well as 443 additional controls. Circulating 25(OH)D3 were measured in pre-diagnostic samples and evaluated in relation to HNC and oesophagus cancer risk and post-diagnosis all-cause mortality...
November 4, 2016: Scientific Reports
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