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https://www.readbyqxmd.com/read/29774147/social-group-disparities-in-the-incidence-and-prognosis-of-oesophageal-cancer
#1
REVIEW
Shao-Hua Xie, Jesper Lagergren
There are substantial disparities in the incidence and prognosis of oesophageal cancer across social population groups, including sex, race/ethnicity, geographical location and socio-economic status. Both squamous cell carcinoma and adenocarcinoma of the oesophagus are more common in men than in women, but the male predominance in adenocarcinoma is stronger and less well understood. The varying incidence and prognosis of oesophageal cancer across racial/ethnic groups show distinct patterns by histological type...
April 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29760376/the-novel-19q13-krab-zinc-finger-tumour-suppressor-znf382-is-frequently-methylated-in-oesophageal-squamous-cell-carcinoma-and-antagonises-wnt-%C3%AE-catenin-signalling
#2
Chong Zhang, Tingxiu Xiang, Shuman Li, Lin Ye, Yixiao Feng, Lijiao Pei, Lili Li, Xiangyu Wang, Ran Sun, Qian Tao, Guosheng Ren
Zinc finger proteins (ZFPs) are the largest transcription factor family in mammals. About one-third of ZFPs are Krüppel-associated box domain (KRAB)-ZFPs and involved in the regulation of cell differentiation/proliferation/apoptosis and neoplastic transformation. We recently identified ZNF382 as a novel KRAB-ZFP epigenetically inactivated in multiple cancers due to frequent promoter CpG methylation. However, its epigenetic alterations, biological functions/mechanism and clinical significance in oesophageal squamous cell carcinoma (ESCC) are still unknown...
May 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29737322/robotic-assisted-minimally-invasive-oesophagectomy-for-cancer-an-initial-experience
#3
Chinnusamy Palanivelu, Sumanta Dey, Sandeep Sabnis, Raghavendra Gupta, Bharath Cumar, Saravana Kumar, Ramesh Natarajan, Parthasarathi Ramakrishnan
Background: The morbidity related to radical oesophagectomy can be reduced by adopting minimally invasive techniques. Over 250 thoraco-laparoscopic oesophagectomy (TLE) was done in our centre over the last 15 years, before adopting robotic surgery as the latest innovation in the field of minimally invasive surgery. Here, we share our initial experience of robotic-assisted minimally invasive oesophagectomy (RAMIE) for carcinoma oesophagus. Methods: A prospective observational study conducted from February to December 2017...
May 4, 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29730158/how-to-get-the-most-out-of-costly-barrett-s-oesophagus-surveillance
#4
Barbara Braden, Evonne Jones-Morris
Current endoscopic surveillance protocols for Barrett's oesophagus have several limitations, mainly the poor cost-effectiveness and high miss rate. However, there is sufficient evidence that patients enrolled in a surveillance program have better survival chances of oesophageal cancer due to earlier tumor stages at diagnosis compared to patients with de novo diagnosed oesophagus cancer. Risk stratifications aim to identify patients at highest risk of developing adenocarcinoma of the oesophagus; most of them base on the length of the Barrett's segment and the presence of dysplasia...
April 22, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29725274/her-2-protein-overexpression-in-patients-with-gastric-and-oesophageal-adenocarcinoma-at-a-tertiary-care-facility-in-ghana
#5
David Larbi Simpong, Richard Harry Asmah, Cecilia Krampah, Patrick Kafui Akakpo, Patrick Adu, Du-Bois Asante, Simon Naporo, Andrew Anthony Adjei, Richard Kwasi Gyasi
The prognosis of gastric and oesophageal adenocarcinoma remains generally poor. However, mounting evidence suggests a positive role of human epidermal growth factor receptor-2 (HER-2) expression in the prognosis of patients with these cancers. In this work, the patterns of HER-2 protein expression were determined in patients with gastric or oesophageal adenocarcinoma. Retrospectively, we reviewed records of gastric and oesophageal biopsies received from 2008 to 2012 and their corresponding archived formalin-fixed paraffin-embedded tissue blocks selected for immunohistochemical analysis...
2018: TheScientificWorldJournal
https://www.readbyqxmd.com/read/29708994/profiles-of-patient-and-tumour-characteristics-in-relation-to-health-related-quality-of-life-after-oesophageal-cancer-surgery
#6
Poorna Anandavadivelan, Anna Wikman, Asif Johar, Pernilla Lagergren
Strong deterioration in health-related quality of life (HRQOL) is a major concern in a sub-group of long-term oesophageal cancer survivors. This study aimed to identify potential clustering of patients and tumour variables that predicts such deterioration. Patient and tumour variables were collected in a prospective cohort of patients who underwent surgery for oesophageal cancer in Sweden 2001-2005. Latent cluster analysis identified statistically significant clustering of these variables. Multivariable logistic regression adjusted for age, BMI, tumour stage and marital status was used to determine odds ratios (ORs) with 95% confidence intervals (CIs) between patient profiles and HRQOL at 3 and 5 years from surgery...
2018: PloS One
https://www.readbyqxmd.com/read/29693248/risk-for-virus-and-non-virus-related-malignancies-following-immunosuppression-in-a-cohort-of-liver-transplant-recipients-italy-1985-2014
#7
Martina Taborelli, Pierluca Piselli, Giuseppe Maria Ettorre, Augusto Lauro, Laura Galatioto, Umberto Baccarani, Maria Rendina, Sarah Shalaby, Raffaella Petrara, Francesco Nudo, Luca Toti, Daniele Sforza, Giovanni Fantola, Claudia Cimaglia, Alessandro Agresta, Giovanni Vennarecci, Antonio Daniele Pinna, Salvatore Gruttadauria, Andrea Risaliti, Alfredo Di Leo, Patrizia Burra, Massimo Rossi, Giuseppe Tisone, Fausto Zamboni, Diego Serraino
This cohort study assessed, in Italy, the overall pattern of risk for de novo malignancies following liver transplantation (LT). The study group included 2832 individuals who underwent LT between 1985 and 2014 in nine centres throughout all of Italy. Person-years (PYs) at cancer risk were computed from 30 days after LT to the date of cancer diagnosis, to the date of death, or to the end of follow-up. Excess cancer risk, as compared to the general population, was estimated using standardized incidence ratios (SIRs) and 95% confidence intervals (CIs)...
April 25, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29679113/increased-evidence-for-the-prognostic-value-of-fdg-uptake-on-late-treatment-pet-in-non-tumour-affected-oesophagus-in-irradiated-patients-with-oesophageal-carcinoma
#8
Yimin Li, Frank Hofheinz, Christian Furth, Chen Lili, Wu Hua, Pirus Ghadjar, Sebastian Zschaeck
PURPOSE: 18 F-FDG uptake in irradiated non-tumour-affected oesophagus (NTO) on restaging PET is a potential surrogate for the measurement of radiation-induced inflammation. Radiation-induced inflammation itself has been shown to be of high prognostic relevance in patients undergoing preoperative radiochemotherapy (RCT) for locally advanced oesophageal cancer. We assessed the prognostic relevance of FDG uptake in the NTO in an independent cohort of patients treated with definitive RCT...
April 21, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29669820/cancer-mortality-in-an-international-cohort-of-reinforced-plastics-workers-exposed-to-styrene-a-reanalysis
#9
Dana Loomis, Neela Guha, Manolis Kogevinas, Vincenzo Fontana, Valerio Gennaro, Henrik A Kolstad, Damien Martin McElvenny, Markku Sallmén, Rodolfo Saracci
OBJECTIVE: To investigate the carcinogenicity of styrene by reanalysing data from a previous international cohort study of workers in the reinforced plastics industry. METHODS: Mortality from cancers of prior interest was analysed with more detailed consideration of exposure-response relations and an updated classification of leukaemias and lymphomas in data from a previous international cohort study of 37 021 reinforced plastics workers exposed to airborne styrene...
April 17, 2018: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29665326/towards-developing-a-meaningful-grading-system-for-cervical-squamous-cell-carcinoma
#10
W Glenn McCluggage
Cervical cancer is one of the commonest cancers worldwide, especially in developing countries. In early stage disease, a variety of pathological parameters are of prognostic value but currently this does not include tumour grade which, for a number of reasons, is of limited or no value in cervical squamous cell carcinomas. In a recent article in this journal, Jesinghaus and colleagues investigated a novel histopathological grading system based on tumour budding and cell nest size, which has been shown to outperform conventional grading systems for squamous cell carcinoma at several other sites such as lung, oral cavity, and oesophagus in terms of patient prognostication...
April 2018: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/29657608/the-use-of-endoscopic-ultrasonography-in-the-detection-and-differentiation-of-pathology-in-the-wall-of-the-upper-gastrointestinal-tract
#11
Przemysław Dyrla, Jerzy Gil, Stanisław Niemczyk, Marek Saracyn, Krzysztof Kosik, Sebastian Czarkowski, Arkadiusz Lubas
Introduction: The growing incidence of gastrointestinal diseases forces to improve imaging techniques. Identification of lesions located inside the wall of intestinal tract or in close proximity often was not possible using endoscopy or computed tomography. Aim: To assess the usefulness of endosonography (EUS) in the differentiation between compression from the outside and intramural lesions of the upper gastrointestinal tract. Material and methods: For 4 years 20,012 patients with performed gastroscopies were enrolled in the study...
2018: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/29649250/what-drives-centralisation-in-cancer-care
#12
Melvin J Kilsdonk, Sabine Siesling, Boukje A C van Dijk, Michel W Wouters, Wim H van Harten
BACKGROUND: To improve quality of care, centralisation of cancer services in high-volume centres has been stimulated. Studies linking specialisation and high (surgical) volumes to better outcomes already appeared in the 1990's. However, actual centralisation was a difficult process in many countries. In this study, factors influencing the centralisation of cancer services in the Netherlands were determined. MATERIAL AND METHODS: Centralisation patterns were studied for three types of cancer that are known to benefit from high surgical caseloads: oesophagus-, pancreas- and bladder cancer...
2018: PloS One
https://www.readbyqxmd.com/read/29602454/optimise-the-microbial-flora-with-milk-and-yoghurt-to-prevent-disease
#13
James A Morris
Pathogenic bacteria, which are temporary or permanent members of our microbial flora, cause or contribute to a wide range of human disease at all ages. Conditions include Alzheimer's disease, atherosclerosis, diabetes mellitus, obesity, cancer, autoimmunity and psychosis, amongst others. The mechanism of damage is inflammation which can be chronic or acute. An optimal microbial flora includes a wide range of pathogenic bacteria in low dose. This allows specific immunity to be developed and maintained with minimal inflammatory damage...
May 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29582802/the-surgical-outcome-of-minimally-invasive-pharyngo-laryngo-oesophagectomy-in-prone-position
#14
Mariko Ogino, Yuma Ebihara, Akihiro Homma, Kimitaka Tanaka, Yoshitsugu Nakanishi, Toshimichi Asano, Takehiro Noji, Yo Kurashima, Soichi Murakami, Toru Nakamura, Takahiro Tsuchikawa, Keisuke Okamura, Toshiaki Shichinohe, Satoshi Hirano
PURPOSE: Pharyngo-laryngo-oesophagectomy (PLE) which is mainly indicated for cervical oesophageal cancer or synchronous double cancer of the thoracic oesophagus and the pharynx or larynx, is extremely invasive. Since minimally invasive oesophagectomy (MIE) using video-assisted thoracic surgery has become popular recently, the procedure can be adopted to PLE. Moreover, the use of the prone position (PP) in MIEs has been increasing recently because technical advantages and fewer post-operative complications were reported...
March 23, 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29573846/a-prospective-phase-i-ii-study-of-docetaxel-cisplatin-and-continuous-capecitabine-in-advanced-oesophago-gastric-cancer-nwcog-3
#15
S Gollins, S Massalha, A Mullard, R M Williams, A Lloyd, J Morris, A Garcia-Alonso
AIMS: This open-label prospective phase I/II dose-escalation study determined the maximum tolerated dose (MTD) and then evaluated response, safety and feasibility of a novel combination of docetaxel, cisplatinum and capecitabine (DCC) in chemotherapy-naive patients with advanced oesophago-gastric carcinoma. MATERIALS AND METHODS: Patients with adenocarcinoma or squamous cell carcinoma of the oesophagus or stomach, of good performance status, deemed too advanced for curative treatment, were given systematically increasing doses of 3 weekly DCC to ascertain the MTD...
March 21, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29573203/cruciferous-vegetables-and-risk-of-cancers-of-the-gastrointestinal-tract
#16
REVIEW
Ian Terence Johnson
Cancers of the oropharyngeal tissues, oesophagus, stomach and colorectum are amongst the most common causes of death from cancer throughout the world. Higher consumption of fruits and vegetables is thought to be protective, and cruciferous vegetables are of particular interest because of their unique role as a source of biologically active glucosinolate breakdown products. A literature review of primary studies and meta-analyses indicates that higher consumption of cruciferous vegetables probably reduces the risk of colorectal and gastric cancers by approximately 8% and 19% respectively...
March 23, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29563637/trends-and-projections-in-adenocarcinoma-and-squamous-cell-carcinoma-of-the-oesophagus-in-england-from-1971-to-2037
#17
Judith Offman, Francesca Pesola, Peter Sasieni
BACKGROUND: The aim of this study was to assess the incidence and trends of oesophageal adenocarcinomas (OACs) and squamous cell carcinomas (OSCCs) in England from 1971 to 2037. METHODS: Data on 220,026 oesophageal cancers diagnosed in England between 1971 and 2013 were extracted. Multiple imputation was used to predict morphology data were missing. Incidence rates were modelled and extrapolated to 2037 using age-period-cohort models. RESULTS: The OAC age-standardised incidence rate (ASRs) increase was greatest from 1972 to 1992 (from 4...
March 22, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29555576/aberrant-high-expression-level-of-morc2-is-a-common-character-in-multiple-cancers
#18
Ding Qian-Shan, Zhang Li, Wang Bi-Cheng, Zeng Zhi, Zou Xian-Qiong, Cao Peng-Bo, M S Zhou Guang-Ming, Tang Meng, Wu Lu, B S Wu Lian-Lian, Yu Hong-Gang, Guo Yong, Zhou Fu-Xiang
Microrchidia 2 (MORC2) plays important roles in DNA damage repair and lipogenesis, but the clinical and functional role of MORC2 in cancer remains largely unexplored. In this study, we showed that MORC2 was widely expressed in human tissues while significantly up-regulated in most cancer types employing immunohistochemical staining and analysis of mRNA expression profile of more than 2000 human tissue samples from 15 different organs (lung, prostate, liver, breast, brain, stomach, colon/rectum, pancreas, ovary, endometrium, skin, nasopharynx, kidney, oesophagus and bladder)...
March 16, 2018: Human Pathology
https://www.readbyqxmd.com/read/29548561/cancer-trials-ireland-icorg-06-34-a-multi-centre-clinical-trial-using-three-dimensional-conformal-radiation-therapy-to-reduce-the-toxicity-of-palliative-radiation-for-lung-cancer
#19
Ronan L McDermott, John G Armstrong, Pierre Thirion, Mary Dunne, Marie Finn, Cormac Small, Mary Byrne, Carmel O'Shea, Lydia O'Sullivan, Aoife Shannon, Emma Kelly, Dayle J Hacking
TITLE: Cancer Trials Ireland (ICORG) 06-34: A multi-centre clinical trial using three-dimensional conformal radiation therapy to reduce the toxicity of palliative radiation for lung cancer. NCT01176487. BACKGROUND & PURPOSE: Trials of radiation therapy for the palliation of intra-thoracic symptoms from locally advanced non-small cell lung cancer (NSCLC) have concentrated on optimising fractionation and dose schedules. In these trials, the rates of oesophagitis induced by this "palliative" therapy have been unacceptably high...
March 13, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29532460/hormonal-and-reproductive-factors-and-risk-of-upper-gastrointestinal-cancers-in-men-a-prospective-cohort-study-within-the-uk-biobank
#20
Úna C Mc Menamin, Andrew T Kunzmann, Michael B Cook, Brian T Johnston, Liam J Murray, Andrew D Spence, Marie M Cantwell, Chris R Cardwell
Incidence of upper gastrointestinal cancers of the oesophagus and stomach show a strong unexplained male predominance. Hormonal and reproductive factors have been associated with upper gastrointestinal cancers in women but there is little available data on men. To investigate this, we included 219,425 men enrolled in the UK Biobank in 2006-2010. Baseline assessments provided information on hormonal and reproductive factors (specifically hair baldness, number of children fathered, relative age at first facial hair and relative age voice broke) and incident oesophageal or gastric cancers were identified through linkage to U...
March 13, 2018: International Journal of Cancer. Journal International du Cancer
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