keyword
MENU ▼
Read by QxMD icon Read
search

Glycogen and fatigue

keyword
https://www.readbyqxmd.com/read/27882212/resveratrol-and-exercise
#1
Saltuk Bugra Baltaci, Rasim Mogulkoc, Abdulkerim Kasim Baltaci
Although it is recommended for a healthy lifestyle, moderate exercise is known to lead to oxidative stress, inflammation and muscle injury. Hence there are efforts to develop dietary strategies to counter the oxidative stress caused by physical activity. Recently, there has been an interest in the capability of resveratrol (RES) to modulate physical performance and prevent oxidative stress. Despite the inconsistency among reports regarding the topic, it has been suggested that RES delays fatigue by hindering lipid peroxidation...
November 2016: Biomedical Reports
https://www.readbyqxmd.com/read/27834150/intranasal-delivery-of-microspheres-loaded-with-20-r-ginsenoside-rg3-enhances-anti-fatigue-effect-in-mice
#2
Wei Zhang, Xiaoyu Wang, Min Zhang, Min Xu, Wenyan Tang, Yi Zhang, Lei Lu, Jing Gao, Shen Gao
Nasal delivery of 20 (R) -ginsenoside Rg3 (Rg3) has a short-lived anti-fatigue effect owing to rapid clearance by nasal cilia. Thus, in order to extend the residence time of Rg3 in the nasal cavity, a new drug delivery system is needed. Chitosan microspheres loaded with Rg3 were prepared using a multi-step emulsification method. They had a spherical shape with a mean diameter of 44.9±12.6 µm. The drug-loading ratio was 10.25±0.08%, and the encapsulation ratio was 30.61±1.46%. Our in vitro mucoadhesion experiment demonstrated that 70...
November 9, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27806677/power-duration-relationship-physiology-fatigue-and-the-limits-of-human-performance
#3
Mark Burnley, Andrew M Jones
The duration that exercise can be maintained decreases as the power requirements increase. In this review, we describe the power-duration (PD) relationship across the full range of attainable power outputs in humans. We show that a remarkably small range of power outputs is sustainable (power outputs below the critical power, CP). We also show that the origin of neuromuscular fatigue differs considerably depending on the exercise intensity domain in which exercise is performed. In the moderate domain (below the lactate threshold, LT), fatigue develops slowly and is predominantly of central origin (residing in the central nervous system)...
November 3, 2016: European Journal of Sport Science
https://www.readbyqxmd.com/read/27783320/lignans-rich-extract-from-herpetospermum-caudigerum-alleviate-physical-fatigue-in-mice
#4
Shi-Ying Jin, Rui-Sheng Li, Bao-de Shen, Jin-Xia Bai, Ping-Hua Xu, Ling Dai, He Xu, Shi-Xiao Jin, Jin Han, Hai-Long Yuan
OBJECTIVE: To ascertain anti-fatigue constituents and mechanisms of Herpetospermum caudigerum. METHODS: The 80% ethanol extracts of Herpetospermum caudigerum were partitioned with chloroform, ethyl acetate and n-butanol, respectively. Male Kunming mice were divided into 13 groups with 16 mice in each group: a control group fed with water, 9 groups treated with 3 fractions of Herpetospermum caudigerum (chloroform fraction, ethyl acetate fraction and n-butanol fraction) at dose of 80, 160 and 320 mg/kg for the low-dose group, medium-dose group and high-dose group, 3 herpetrione (HPE) treated groups fed with HPE at dose of 15, 30, and 60 mg/kg for the low-dose group, medium-dose group and high-dose group...
November 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27775591/capsaicin-supplementation-reduces-physical-fatigue-and-improves-exercise-performance-in-mice
#5
Yi-Ju Hsu, Wen-Ching Huang, Chien-Chao Chiu, Yan-Lin Liu, Wan-Chun Chiu, Chun-Hui Chiu, Yen-Shuo Chiu, Chi-Chang Huang
Chili pepper is used as a food, seasoning and has been revered for its medicinal and health claims. It is very popular and is the most common spice worldwide. Capsaicin (CAP) is a major pungent and bioactive phytochemical in chili peppers. CAP has been shown to improve mitochondrial biogenesis and adenosine triphosphate (ATP) production. However, there is limited evidence around the effects of CAP on physical fatigue and exercise performance. The purpose of this study was to evaluate the potential beneficial effects of CAP on anti-fatigue and ergogenic functions following physiological challenge...
October 20, 2016: Nutrients
https://www.readbyqxmd.com/read/27766021/dehydroepiandrosterone-supplementation-combined-with-whole-body-vibration-training-affects-testosterone-level-and-body-composition-in-mice
#6
Wen-Chyuan Chen, Yi-Ming Chen, Chi-Chang Huang, Yen-Dun Tzeng
Dehydroepiandrosterone (DHEA), the most abundant sex steroid, is primarily secreted by the adrenal gland and a precursor hormone used by athletes for performance enhancement. Whole-body vibration (WBV) is a well-known light-resistance exercise by automatic adaptations to rapid and repeated oscillations from a vibrating platform, which is also a simple and convenient exercise for older adults. However, the potential effects of DHEA supplementation combined with WBV training on to body composition, exercise performance, and hormone regulation are currently unclear...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27713820/fibromyalgia-syndrome-metabolic-and-autophagic-processes-in-intermittent-cold-stress-mice
#7
Lisa Oezel, Hanna Then, Anna L Jung, Samir Jabari, Gabriel A Bonaterra, Thaddeus T Wissniowski, Susanne F Önel, Matthias Ocker, Kati Thieme, Ralf Kinscherf, Pietro Di Fazio
Fibromyalgia is characterized by widespread musculoskeletal pain, fatigue, and depression. The aim was to analyze potential mitochondrial dysfunction or autophagy in mice after exposure to intermittent cold stress (ICS). Muscle and liver specimens were obtained from 36 mice. Lactate dehydrogenase (LDH) activity was measured. Microtubule-associated protein light chain 3 (MAP1LC3B) and glycogen content were determined histologically; muscle ultrastructure by electron microscopy. Mitochondrial- and autophagy-related markers were analyzed by RT-qPCR and Western blotting...
October 2016: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/27679573/orm-promotes-skeletal-muscle-glycogen-accumulation-via-ccr5-activated-ampk-pathway-in-mice
#8
Zhen Qin, Jing-Jing Wan, Yang Sun, Peng-Yuan Wang, Ding-Feng Su, Hong Lei, Xia Liu
We found previously that acute phase protein orosomucoid reacts to fatigue and activates C-C chemokine receptor type 5 to increase muscle glycogen storage and enhance muscle endurance (Lei et al., 2016). To explore the underlying molecular mechanisms, we investigated the role of AMP-activated protein kinase, a critical fuel sensor in skeletal muscle, in C-C chemokine receptor type 5-mediated orosomucoid action. It was found orosomucoid increased skeletal muscle AMP-activated protein kinase activation in a time- and dose- dependent manner, which was largely prevented by pharmacological blocking or knockout of C-C chemokine receptor type 5...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27636512/anti-fatigue-effect-by-active-dipeptides-of-fermented-porcine-placenta-through-inhibiting-the-inflammatory-and-oxidative-reactions
#9
Sun-Young Nam, Hyung-Min Kim, Hyun-Ja Jeong
BACKGROUND: Recently, we reported an anti-fatigue effect of fermented porcine placenta (FPP). Glycine-leucine (GL) and leucine-glycine (LG) dipeptides are main peptides of FPP. However, the therapeutic effects and underlying mechanisms of GL and LG dipeptides on fatigue are still unclear. METHODS: Herein, we examined the anti-fatigue properties of GL and LG dipeptides using RAW264.7 macrophages and forced swimming test (FST) animal model. RESULTS: Our data revealed that lipopolysaccharide (LPS)-induced interleukin (IL)-1β, tumor necrosis factor-α, and IL-6 productions were markedly inhibited by GL or LG in RAW264...
September 13, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27601853/antifatigue-effects-of-ethanol-extracts-and-polysaccharides-isolated-from-abelmoschus-esculentus
#10
Yu-Xian Li, Zhong-Han Yang, Yin Lin, Wei Han, Shan-Shan Jia, Ke Yuan
BACKGROUND: The aim of this study is to determine the antifatigue active fraction from Abelmoschus esculentus. The in vivo antifatigue effects of ethanol extracts and polysaccharides from A. esculentus fruit have been determined. The polysaccharides of A. esculentus were determined as the best effective fractions of antifatigue effects. MATERIALS AND METHODS: About 360 Kunming male mice were randomly divided into nine subgroups: normal control subgroup, model subgroup, positive subgroup and the ethanol extracts of A...
July 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27525900/genetic-evaluation-of-ampd1-cpt2-and-pgym-metabolic-enzymes-in-patients-with-chronic-fatigue-syndrome
#11
P E Maltese, L Venturini, E Poplavskaya, M Bertelli, S Cecchin, M Granato, S Y Nikulina, A Salmina, N Aksyutina, E Capelli, G Ricevuti, L Lorusso
Chronic fatigue syndrome (CFS) is a disease that can seriously impair one's quality of life; patients complain of excessive fatigue and myalgia following physical exertion. This disease may be associated with abnormalities in genes affecting exercise tolerance and physical performance. Adenosine monophosphate deaminase (AMPD1), carnitine palmitoyltransferase II (CPT2), and the muscle isoform of glycogen phosphorylase (PYGM) genes provide instructions for producing enzymes that play major roles in energy production during work...
2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27488667/katp-channel-deficiency-in-mouse-fdb-causes-an-impairment-of-energy-metabolism-during-fatigue
#12
Kyle Scott, Maria Benkhalti, Nicholas D Calvert, Mathieu Paquette, Li Zhen, Mary-Ellen Harper, Osama Y Al-Dirbashi, Jean-Marc Renaud
The skeletal muscle ATP-sensitive K(+) (KATP) channel is crucial in preventing fiber damage and contractile dysfunction, possibly by preventing damaging ATP depletion. The objective of this study was to investigate changes in energy metabolism during fatigue in wild-type and inwardly rectifying K(+) channel (Kir6.2)-deficient (Kir6.2(-/-)) flexor digitorum brevis (FDB), a muscle that lacks functional KATP channels. Fatigue was elicited with one tetanic contraction every second. Decreases in ATP and total adenylate levels were significantly greater in wild-type than Kir6...
October 1, 2016: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/27439540/effect-of-fermented-porcine-placenta-on-physical-fatigue-in-mice
#13
Hee-Yun Kim, Na-Ra Han, Na-Rae Kim, Mikyung Lee, Jongbae Kim, Chang-Ju Kim, Hyun-Ja Jeong, Hyung-Min Kim
The fatigue spreads among the people who live under stressful life and brings about a negative impact on physical function. Here we evaluated the anti-fatigue effects of fermented porcine placenta (FPP) and main constituents, lysine (Lys) and leucine (Leu) with treadmill stress test and forced swimming test (FST) in animal models. The mice were administrated with FPP, Lys, and Leu for 21 days. After treadmill exercise, FPP, Lys, and Leu significantly reduced fatigue-related biochemical parameters, including lactate, lactate dehydrogenase, glucose, creatine kinase, urea nitrogen, cortisol, and pro-inflammatory cytokines, whereas superoxide dismutase activity and glycogen levels were significantly increased by FPP, Lys, and Leu...
November 2016: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27434080/no-muscle-is-an-island-integrative-perspectives-on-muscle-fatigue
#14
Jane A Kent, Niels Ørtenblad, Michael C Hogan, David C Poole, Timothy I Musch
Muscle fatigue has been studied with a variety approaches, tools and technologies. The foci of these studies have ranged tremendously, from molecules to the entire organism. Single cell and animal models have been used to gain mechanistic insight into the fatigue process. The theme of this review is the concept that the mechanisms of muscle fatigue do not occur in isolation in vivo: muscular work is supported by many complex physiological systems, any of which could fail during exercise and thus contribute to fatigue...
November 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27408821/hypothyroidism-in-late-onset-pompe-disease
#15
Joseph Schneider, Lynn A Burmeister, Kyle Rudser, Chester B Whitley, Jeanine Jarnes Utz
PURPOSE: In Pompe disease, a deficiency of acid α-glucosidase enzyme activity leads to pathologic accumulation of glycogen in tissues. Phenotype heterogeneity in Pompe includes an infantile form and late-onset forms (juvenile- and adult-onset forms). Symptoms common to all phenotypes include progressive muscle weakness and worsening respiratory function. Patients with late-onset forms of Pompe disease commonly complain of chronic fatigue and generalized muscle weakness prior to being diagnosed with Pompe disease, and this may lead to consideration of hypothyroidism in the differential diagnosis...
September 2016: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/27402793/in-the-absence-of-phosphate-shuttling-exercise-reveals-the-in-vivo-importance-of-creatine-independent-mitochondrial-adp-transport
#16
Paula M Miotto, Graham P Holloway
The transport of cytosolic adenosine diphosphate (ADP) into the mitochondria is a major control point in metabolic homeostasis, as ADP concentrations directly affect glycolytic flux and oxidative phosphorylation rates within mitochondria. A large contributor to the efficiency of this process is thought to involve phosphocreatine (PCr)/Creatine (Cr) shuttling through mitochondrial creatine kinase (Mi-CK), whereas the biological importance of alterations in Cr-independent ADP transport during exercise remains unknown...
September 15, 2016: Biochemical Journal
https://www.readbyqxmd.com/read/27284418/deep-sea-water-improves-exercise-and-inhibits-oxidative-stress-in-a-physical-fatigue-mouse-model
#17
Huijie Fan, Zhangbin Tan, Yue Hua, Xiaofang Huang, Yiting Gao, Yuting Wu, Bin Liu, Yingchun Zhou
Physical fatigue is extremely common and occurs daily, and is considered to be associated with oxidative stress. The diverse functions of deep sea water (DSW) have recently gained increasing attention. Previous studies have emphasized the anti-fatigue effect of DSW, but the intrinsic mechanism behind the effect remains to be elucidated. In the imprinting control region (ICR) mice model, DSW delayed the exhaustive swimming time. In addition, DSW decreased the area under the blood lactate (BLA) curve, which was associated with the area under the BLA curve of pre-swimming, post-swimming and post-rest...
June 2016: Biomedical Reports
https://www.readbyqxmd.com/read/27277193/acute-paraquat-exposure-determines-dose-dependent-oxidative-injury-of-multiple-organs-and-metabolic-dysfunction-in-rats-impact-on-exercise-tolerance
#18
Rômulo D Novaes, Reggiani V Gonçalves, Marli C Cupertino, Eliziária C Santos, Solange M Bigonha, Geraldo J M Fernandes, Izabel R S C Maldonado, Antônio J Natali
This study investigated the pathological morphofunctional adaptations related to the imbalance of exercise tolerance triggered by paraquat (PQ) exposure in rats. The rats were randomized into four groups with eight animals each: (a) SAL (control): 0.5 ml of 0.9% NaCl solution; (b) PQ10: PQ 10 mg/kg; (c) PQ20: PQ 20 mg/kg; and (d) PQ30: PQ 30 mg/kg. Each group received a single injection of PQ. After 72 hours, the animals were subjected to an incremental aerobic running test until fatigue in order to determine exercise tolerance, blood glucose and lactate levels...
April 2016: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/27229694/-persistently-elevated-hepatic-transaminases-a-patient-with-late-onset-pompe-disease
#19
K J C Sanders, M C E Hermans, G H Koek
BACKGROUND: Pompe disease is a rare hereditary glycogen storage disease. Disease progression can be delayed by enzyme replacement therapy, which makes early identification important. Sometimes, the clinical presentation can be atypical, which may result in late recognition. CASE DESCRIPTION: A 23-year-old male presented with mild fatigue and persistently elevated liver transaminase levels. Biochemical, metabolic, viral, autoimmune, and toxicological examination, augmented with imaging and liver biopsy, initially did not result in a diagnosis...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27199539/a-multi-parametric-protocol-to-study-exercise-intolerance-in-mcardle-s-disease
#20
Giulia Ricci, Federica Bertolucci, Annalisa Logerfo, Costanza Simoncini, Riccardo Papi, Ferdinando Franzoni, Giacomo Dell'Osso, Adele Servadio, Maria Chiara Masoni, Gabriele Siciliano
McArdle's disease is the most common metabolic myopathy of muscle carbohydrate metabolism, due to deficiency of myophosphorylase and alteration of glycogen breakdown in muscle. The clinical manifestations usually begin in young adulthood, with exercise intolerance, exercise-induced muscle cramps, pain and recurrent episodes of myoglobinuria. Many patients experience the second wind phenomenon, characterized by an improved tolerance for aerobic exercise approximately after eight minutes of motor activity, secondary to the increased availability of blood glucose and free fatty acids associated to an enhanced glucose uptake by muscle cells...
December 2015: Acta Myologica: Myopathies and Cardiomyopathies: Official Journal of the Mediterranean Society of Myology
keyword
keyword
102819
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"