keyword
MENU ▼
Read by QxMD icon Read
search

Islet transplant

keyword
https://www.readbyqxmd.com/read/28814629/modular-tissue-engineering-for-the-vascularization-of-subcutaneously-transplanted-pancreatic-islets
#1
Alexander E Vlahos, Nicholas Cober, Michael V Sefton
The transplantation of pancreatic islets, following the Edmonton Protocol, is a promising treatment for type I diabetics. However, the need for multiple donors to achieve insulin independence reflects the large loss of islets that occurs when islets are infused into the portal vein. Finding a less hostile transplantation site that is both minimally invasive and able to support a large transplant volume is necessary to advance this approach. Although the s.c. site satisfies both these criteria, the site is poorly vascularized, precluding its utility...
August 16, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28803916/mitigating-ischemic-injury-of-stem-cell-derived-insulin-producing-cells-after-transplant
#2
Gaetano Faleo, Holger A Russ, Steven Wisel, Audrey V Parent, Vinh Nguyen, Gopika G Nair, Jonathan E Freise, Karina E Villanueva, Gregory L Szot, Matthias Hebrok, Qizhi Tang
The advent of large-scale in vitro differentiation of human stem cell-derived insulin-producing cells (SCIPC) has brought us closer to treating diabetes using stem cell technology. However, decades of experiences from islet transplantation show that ischemia-induced islet cell death after transplant severely limits the efficacy of the therapy. It is unclear to what extent human SCIPC are susceptible to ischemia. In this study, we show that more than half of SCIPC die shortly after transplantation. Nutrient deprivation and hypoxia acted synergistically to kill SCIPC in vitro...
August 8, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28801292/-oxidized-low-density-lipoprotein-modulates-differentiation-of-murine-memory-cd8-t-cell-subpopulations
#3
Hua Zheng, Ze-Hang Lin, Yan-Mei Zhang, Chen-Fei Zhou, Xuan Liu, Sha Wu
OBJECTIVE: To investigate effect of oxidized low-density lipoprotein (ox-LDL) on memory CD8(+) T cell subpopulation differentiation in mice with autoimmune diabetes. METHODS: Cultured splenic CD8(+) T cells from pre-diabetic NOD mice isolated with magnetic beads were treated with 30 µg/mL ox-LDL and 10 U/mL interleukin-2 (IL-2) for 24 h and the control cells were treated with IL-2 only. Flow cytometry was used to determine the percentage of splenic CD8(+)IFN-γ(+) T cells, expressions of CD8, CD44 and CD62L on the T cells, and the activation of T cell factor-1 (TCF-1) and STAT-3...
August 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28795955/editorial-pancreatic-islet-cell-transplantation
#4
Marlon F Levy
No abstract text is available yet for this article.
August 8, 2017: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/28795677/-one-case-of-concurrent-hemorrhage-after-pancreatic-islet-transplantation-by-percutaneous-transhepatic-portal-approach
#5
Boya Zhang, Guanghui Pei, Yamin Zhang, Zhiping Wang, Lianjiang Wang, Yan Xie, Jinshan Wang, Shusen Wang
The percutaneous transhepatic portal approach is the most commonly used technique for islet transplantation, largely owing to its safety and minimally invasive characteristic. Bleeding complications after islet transplantation are rare. A case of type 1 diabetes mellitus (T1DM) was treated in Tianjin First Center Hospital, who had a massive intra-abdominal hemorrhage after percutaneous transhepatic portal vein catheterization for islet transplantation. Through the review of the overall development of the case, we aim to improve the awareness of the complications of islet transplantation, to reduce the incidence of complications after percutaneous transhepatic portal vein transplantation, and to provide experience...
August 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28793270/pancreatic-islet-blood-flow-dynamics-in-primates
#6
Juan A Diez, Rafael Arrojo E Drigo, Xiaofeng Zheng, Olga V Stelmashenko, Minni Chua, Rayner Rodriguez-Diaz, Masahiro Fukuda, Martin Köhler, Ingo Leibiger, Sai Bo Bo Tun, Yusuf Ali, George J Augustine, Veluchamy A Barathi, Per-Olof Berggren
Blood flow regulation in pancreatic islets is critical for function but poorly understood. Here, we establish an in vivo imaging platform in a non-human primate where islets transplanted autologously into the anterior chamber of the eye are monitored non-invasively and longitudinally at single-cell resolution. Engrafted islets were vascularized and innervated and maintained the cytoarchitecture of in situ islets in the pancreas. Blood flow velocity in the engrafted islets was not affected by increasing blood glucose levels and/or the GLP-1R agonist liraglutide...
August 8, 2017: Cell Reports
https://www.readbyqxmd.com/read/28791576/tolerogenic-nanoparticles-to-treat-islet-autoimmunity
#7
REVIEW
Tobias Neef, Stephen D Miller
PURPOSE OF REVIEW: The current standard therapy for type 1 diabetes (T1D) is insulin replacement. Autoimmune diseases are typically treated with broad immunosuppression, but this has multiple disadvantages. Induction of antigen-specific tolerance is preferable. The application of nanomedicine to the problem of T1D can take different forms, but one promising way is the development of tolerogenic nanoparticles, the aim of which is to mitigate the islet-destroying autoimmunity. We review the topic and highlight recent strategies to produce tolerogenic nanoparticles for the purpose of treating T1D...
August 8, 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28780165/the-na-ca-2-exchanger-and-the-plasma-membrane-ca-2-atpase-in-%C3%AE-cell-function-and-diabetes
#8
REVIEW
André Herchuelz, Nathalie Pachera
The rat pancreatic β-cell expresses 6 splice variants of the Plasma Membrane Ca(2+)-ATPase (PMCA) and two splice variants of the Na(+)/Ca(2+) exchanger 1 (NCX1). In the β-cell Na(+)/Ca(2+) exchange displays a high capacity, contributes to both Ca(2+) outflow and influx and participates to the control of insulin release. Gain of function studies show that overexpression of PMCA2 or NCX1 leads to endoplasmic reticulum (ER) Ca(2+) depletion with subsequent ER stress, decrease in β-cell proliferation and β-cell death by apoptosis...
August 2, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28775287/non-invasive-in-vivo-determination-of-viable-islet-graft-volume-by-111-in-exendin-3
#9
Wael A Eter, Inge Van der Kroon, Karolina Andralojc, Mijke Buitinga, Stefanie M A Willekens, Cathelijne Frielink, Desiree Bos, Lieke Joosten, Otto C Boerman, Maarten Brom, Martin Gotthardt
Pancreatic islet transplantation is a promising therapy for patients with type 1 diabetes. However, the duration of long-term graft survival is limited due to inflammatory as well as non-inflammatory processes and routine clinical tests are not suitable to monitor islet survival. (111)In-exendin-SPECT (single photon emission computed tomography) is a promising method to non-invasively image islets after transplantation and has the potential to help improve the clinical outcome. Whether (111)In-exendin-SPECT allows detecting small differences in beta-cell mass (BCM) and measuring the actual volume of islets that were successfully engrafted has yet to be demonstrated...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28759462/pig-islet-xenotransplantation
#10
Maheswaran Dhanasekaran, Johnathan J George, Gopalakrishnan Loganathan, Siddharth Narayanan, Michael G Hughes, Stuart K Williams, Appakalai N Balamurugan
PURPOSE OF REVIEW: The current article reviews the rationale, sources and preparation of pig islets for xenotransplantation, and presents current progress in solving the problems associated with establishing pig islet transplant as a clinical treatment for type 1 diabetes. SUMMARY: Islet transplantation is an effective treatment option for type 1 diabetes, but the available supply of human pancreases is insufficient to meet the need and demand for obtaining islets...
July 28, 2017: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/28754712/engineered-islet-cell-clusters-transplanted-into-subcutaneous-space-are-superior-to-pancreatic-islets-in-diabetes
#11
Shiva Pathak, Shobha Regmi, Biki Gupta, Tung Thanh Pham, Chul Soon Yong, Jong Oh Kim, Simmyung Yook, Jae-Ryong Kim, Min Hui Park, Young Kyung Bae, Jee-Heon Jeong
An alternative route for pancreatic islet transplantation is the subcutaneous space; however, inadequate vascularization in the subcutaneous space limits the availability of oxygen and nutrients to the subcutaneously transplanted islets, which leads to the development of a necrotic core in the islets, thereby causing islet dysfunction. Thus, we aimed to prevent the early apoptosis of pancreatic islets after transplantation into subcutaneous space by preparing islet clusters of appropriate size. We prepared fully functional islet-cell clusters (ICCs) by using the hanging drop technique...
July 28, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28751653/biochemical-profiling-of-diabetes-disease-progression-by-multivariate-vibrational-microspectroscopy-of-the-pancreas
#12
Christoffer Nord, Maria Eriksson, Andrea Dicker, Anna Eriksson, Eivind Grong, Erwin Ilegems, Ronald Mårvik, Bård Kulseng, Per-Olof Berggren, András Gorzsás, Ulf Ahlgren
Despite the dramatic increase in the prevalence of diabetes, techniques for in situ studies of the underlying pancreatic biochemistry are lacking. Such methods would facilitate obtaining mechanistic understanding of diabetes pathophysiology and aid in prognostic and/or diagnostic assessments. In this report we demonstrate how a multivariate imaging approach (orthogonal projections to latent structures - discriminant analysis) can be applied to generate full vibrational microspectroscopic profiles of pancreatic tissues...
July 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28748581/coronary-artery-calcium-may-stabilize-following-islet-cell-transplantation-in-patients-with-type-1-diabetes
#13
J M Madrigal, R S Monson, B Hatipoglu, J Oberholzer, G T Kondos, K A Varady, K K Danielson
Islet cell transplantation can functionally cure type 1 diabetes, and also improve carotid-intima media thickness. This study provides a preliminary description of changes in coronary artery calcium following islet transplantation, and associated factors. Coronary artery calcium was measured in 14 patients with type 1 diabetes (11 had measures both pre- and post-transplant [mean 2.3 years]) in the University of Illinois at Chicago's clinical trial. Multivariable mixed-effects linear regression of repeated measures was used to quantify calcium change, and determine if this change was longitudinally associated with risk/protective factors...
July 27, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28748550/porcine-c-peptide-measurement-to-assess-graft-function-in-xenogeneic-porcine-islet-transplantation-editorial-commentary
#14
Henk-Jan Schuurman
No abstract text is available yet for this article.
July 26, 2017: Xenotransplantation
https://www.readbyqxmd.com/read/28738406/trophic-molecules-derived-from-human-mesenchymal-stem-cells-enhance-survival-function-and-angiogenesis-of-isolated-islets-after-transplantation-erratum
#15
(no author information available yet)
No abstract text is available yet for this article.
August 2017: Transplantation
https://www.readbyqxmd.com/read/28737658/regulation-of-clinical-xenotransplantation-time-for-a-reappraisal
#16
David K C Cooper, Richard N Pierson, Bernhard J Hering, Muhammad M Mohiuddin, Jay A Fishman, Joachim Denner, Curie Ahn, Agnes M Azimzadeh, Leo H Buhler, Peter J Cowan, Wayne J Hawthorne, Takaaki Kobayashi, David H Sachs
The continual critical shortage of organs and cells from deceased human donors has stimulated research in the field of cross-species transplantation (xenotransplantation), with the pig selected as the most suitable potential source of organs. Since the US Food and Drug Administration concluded a comprehensive review of xenotransplantation in 2003, considerable progress has been made in the experimental laboratory to improve cell and organ xenograft survival in several pig-to-nonhuman primate systems that offer the best available models to predict clinical outcomes...
August 2017: Transplantation
https://www.readbyqxmd.com/read/28736020/mechanism-for-the-instant-blood-mediated-inflammatory-reaction-in-rat-islet-transplantation
#17
Y Cheng, B Wang, H Li, N Zhao, Y Liu
OBJECTIVE: The purpose of this study was to investigate the mechanisms involved in the development of instant blood-mediated inflammatory reaction (IBMIR) triggered by pancreatic islet transplantation in an in vitro system. MATERIALS AND METHODS: Pancreatic islets were prepared and blood was taken from male and female Wistar rats. An in vitro heparinized tubing loop model on a rocking device that was placed in a 37°C incubator was used to generate blood flow inside the loops...
July 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28735354/transplantation-sites-for-human-and-murine-islets
#18
Rebecca A Stokes, Kim Cheng, Amit Lalwani, Michael M Swarbrick, Helen E Thomas, Thomas Loudovaris, Tom W Kay, Wayne J Hawthorne, Philip J O'Connell, Jenny E Gunton
AIMS/HYPOTHESIS: Beta cell replacement is a potential cure for type 1 diabetes. In humans, islet transplants are currently infused into the liver via the portal vein, although this site has disadvantages. Here, we investigated alternative transplantation sites for human and murine islets in recipient mice, comparing the portal vein with quadriceps muscle and kidney, liver and spleen capsules. METHODS: Murine islets were isolated from C57BL6/J mice and transplanted into syngeneic recipients...
July 22, 2017: Diabetologia
https://www.readbyqxmd.com/read/28734022/3d-printed-vascularized-device-for-subcutaneous-transplantation-of-human-islets
#19
Marco Farina, Andrea Ballerini, Daniel Fraga, Eugenia Nicolov Matthew Hogan, Danilo Demarchi, Francesco Scaglione, Omaima Sabek, Philip Horner, Usha Thekkedath, Osama Gaber, Alessandro Grattoni
Transplantation of pancreatic islets or stem cell derived insulin secreting cells is an attractive treatment strategy for diabetes. However, islet transplantation is associated with several challenges including function-loss associated with dispersion and limited vascularization as well as the need for continuous immunosuppression. To overcome these limitations, here we present a novel 3D printed and functionalized encapsulation system for subcutaneous engraftment of islets or islet like cells. The devices were 3D printed with polylactic acid and the surfaces treated and patterned to increase the hydrophilicity, cell attachment and proliferation...
July 22, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28731996/-pancreatitis-genes-and-islet-cells-auto-transplant-updates-and-new-horizons
#20
Edgardo D Rivera Rivera
Pancreatitis is an inflammation of the pancreas that can progress from an acute presentation to an acute recurring presentation and eventually to chronic pancreatitis, which is characterized by irreversible morphological changes and scarring of the pancreas. The entity known as hereditary pancreatitis has been recognized in the literature for years and certainly the discovery of the PRSS1 gene in 1996 marked the beginning of a new era of genetic discoveries associated with the disease. Since then, multiple genes have been described as the causing agents of pancreatitis or disease modifiers, some of the most important ones being the PRSS1, SPINK1, CFTR, CASR, CTRC, CLDN2, and CPA1...
April 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
keyword
keyword
10281
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"