keyword
https://read.qxmd.com/read/38530568/efficacy-safety-and-immunogenicity-of-sun-s-ranibizumab-biosimilar-in-neovascular-age-related-macular-degeneration-a-phase-3-double-blind-comparative-study
#1
JOURNAL ARTICLE
Asim K Ghosh, Usha S Nikumbh, Chaitanya K Shukla, Rohit S Laul, Abhishek Dixit, Santosh K Mahapatra, Sameera Nayak, Urmil M Shah, Sandeep Parwal, Narendran Venkatapathy, Natasha Radhakrishnan, Anup Kelgaonkar, Sandeep Saxena, Divyansh Mishra, Vivek Pravin Dave, Perwez Khan, Manojkumar R Saswade, Malli S Shantilal, Kim Ramasamy, Smitha Sreekanta, Mandodari Rajurkar, Maulik Doshi, Sapan Behera, Piyush Patel, Shilpi Dhawan, Lalit Lakhwani
INTRODUCTION: The study aimed to evaluate comparability in terms of efficacy, safety and immunogenicity of Sun's ranibizumab biosimilar with reference ranibizumab in patients with neovascular age-related macular degeneration (nAMD). METHODS: This prospective, randomised, double-blind, two-group, parallel-arm, multicentre, phase 3 comparative study included patients with nAMD ≥ 50 years, randomised (in a 2:1 ratio) in a double-blind manner to receive 0...
March 26, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38528623/age-related-macular-degeneration-discordance-in-monozygotic-twin-pairs
#2
JOURNAL ARTICLE
Fabian Kananen, Jaakko Kaprio, Ilkka Immonen
PURPOSE: To examine age-related macular degeneration (AMD) and retinal pigment epithelium (RPE)-Bruch's membrane (BrM) complex volume associations in monozygotic twin pairs. METHODS: In this study, 106 elderly twins (53 twin pairs) from the Finnish Twin Cohort study were recruited. Each participant underwent dilated 35-degree digital colour fundus photography (CFP), and spectral domain optical coherence tomography (OCT) and replied to a structured study questionnaire...
March 25, 2024: Acta Ophthalmologica
https://read.qxmd.com/read/38519026/similar-risk-of-kidney-failure-among-patients-with-blinding-diseases-who-receive-ranibizumab-aflibercept-and-bevacizumab-an-ohdsi-network-study
#3
JOURNAL ARTICLE
Cindy X Cai, Akihiko Nishimura, Mary G Bowring, Erik Westlund, Diep Tran, Jia H Ng, Paul Nagy, Michael Cook, Jody-Ann McLeggon, Scott L DuVall, Michael E Matheny, Asieh Golozar, Anna Ostropolets, Evan Minty, Priya Desai, Fan Bu, Brian Toy, Michelle Hribar, Thomas Falconer, Linying Zhang, Laurence Lawrence-Archer, Michael V Boland, Kerry Goetz, Nathan Hall, Azza Shoaibi, Jenna Reps, Anthony G Sena, Clair Blacketer, Joel Swerdel, Kenar D Jhaveri, Edward Lee, Zachary Gilbert, Scott L Zeger, Deidra C Crews, Marc A Suchard, George Hripcsak, Patrick B Ryan
OBJECTIVE OR PURPOSE: A) To characterize the incidence of kidney failure associated with intravitreal anti-vascular endothelial growth factor (VEGF) exposure, and B) compare the risk of kidney failure in patients treated with ranibizumab, aflibercept, or bevacizumab. DESIGN: Retrospective cohort study across 12 databases in the Observational Health Data Sciences and Informatics (OHDSI) network. SUBJECTS, PARTICIPANTS, AND/OR CONTROLS: Subjects aged ≥18 years with ≥3 monthly intravitreal anti-VEGF medications for a blinding disease (diabetic retinopathy, diabetic macular edema, exudative age-related macular degeneration, or retinal vein occlusion)...
March 20, 2024: Ophthalmology Retina
https://read.qxmd.com/read/38517446/macular-pigment-assessment-in-indian-population-using-degree-of-polarization-threshold-impact-of-diet-on-macular-pigment-density
#4
JOURNAL ARTICLE
Payal Sangani, Shelby Temple, Shashank Bhandary, Raja Narayanan, Elizabeth Johnson, Anthony Vipin Das, Md Hasnat Ali, Brijesh Takkar
PURPOSE: To determine macular pigment (MP) density scores in healthy Indians and examine correlations with demographic and lifestyle variables. METHODS: We observed 484 Indians without an ocular pathology. Body mass index (BMI) and self-reported lifestyle factors (sunglasses usage, physical activity, and smoking) were noted. MP density was assessed as the threshold of perception of the shadow of their macular pigments on their retina using a new MP assessment tool (MP-eye)...
March 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38516283/quantifying-fluid-and-function-in-suboptimal-responders-switched-from-an-anti-vascular-endothelial-growth-factor-vegf-to-faricimab
#5
JOURNAL ARTICLE
David Sutter, Abigail Anderson, Sheila Wheatley, Veeral Sheth
Background Anti-vascular endothelial growth factor (VEGF) injections have been successful in reducing vision loss from neovascular age-related macular degeneration, a leading cause of blindness. Due to the high treatment burden and suboptimal responses, switching to bi-specific faricimab treatment may lead to improved outcomes. Methods This retrospective chart review evaluated if suboptimal responders to anti-VEGF injections had better outcomes when switched to faricimab. Suboptimal responders were defined as patients with a history of >3 months of injections and the presence of fluid after ≥3 injections...
March 2024: Curēus
https://read.qxmd.com/read/38512243/prevalence-of-myopic-maculopathy-among-the-very-old-the-ural-very-old-study
#6
JOURNAL ARTICLE
Mukharram M Bikbov, Timur R Gilmanshin, Gyulli M Kazakbaeva, Songhomitra Panda-Jonas, Jost B Jonas
PURPOSE: To assess the prevalence of myopic macular degeneration (MMD) in very old individuals. METHODS: The population-based Ural Very Old Study (UVOS) included 1526 (81.1%) of 1882 eligible inhabitants aged ≥85 years. Assessable fundus images were available for 930 (60.9%) individuals (mean age, 88.6 ± 2.7 years). MMD was defined by macular patchy atrophies (i.e., MMD stage 3 and 4 as defined by the Pathologic Myopia Study Group). RESULTS: MMD prevalence was 21 of 930 (2...
March 5, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38507599/prevalence-and-risk-factors-of-age-related-macular-degeneration-in-south-korea-korea-national-health-and-nutrition-examination-survey
#7
JOURNAL ARTICLE
Mi Yeon Song, Yeji Kim, Kyungdo Han, Jae Hui Kim
PURPOSE: To evaluate the prevalence and risk factors of age-related macular degeneration (AMD) in the Korean population. METHODS: In this cross-sectional study based on the Korea National Health and Nutrition Examination Survey (2017-2020) data 13,737 participants aged ≥ 40 years with assessable fundus images were included. The prevalence and risk factors of AMD were evaluated. The prevalence of early AMD, geographic atrophy (GA), and neovascular AMD were also assessed...
March 20, 2024: Ophthalmic Epidemiology
https://read.qxmd.com/read/38499857/retinal-sensitivity-changes-in-early-intermediate-amd-a-systematic-review-and-meta-analysis-of-visual-field-testing-under-mesopic-and-scotopic-lighting
#8
REVIEW
Matt Trinh, Michael Kalloniatis, Sieu K Khuu, Lisa Nivison-Smith
Visual fields under mesopic and scotopic lighting are increasingly being used for macular functional assessment. This review evaluates its statistical significance and clinical relevance, and the optimal testing protocol for early/intermediate age-related macular degeneration (AMD). PubMed and Embase were searched from inception to 14/05/2022. All quality assessments were performed according to GRADE guidelines. The primary outcome was global mean sensitivity (MS), further meta-analysed by: AMD classification scheme, device, test pattern, mesopic/scotopic lighting, stimuli size/chromaticity, pupil dilation, testing radius (area), background luminance, adaptation time, AMD severity, reticular pseudodrusen presence, and follow-up visit...
March 18, 2024: Eye
https://read.qxmd.com/read/38494487/preserving-visual-acuity-a-compelling-12-year-case-study-of-controlling-neovascular-age-related-macular-degeneration
#9
JOURNAL ARTICLE
Rita O Tomás, António Campos, Nuno Oliveira, Pedro Soares, João P Sousa
INTRODUCTION: In neovascular age-related macular degeneration (nAMD) trials, anti-VEGF injection frequency decreases after the first year, while outcomes remain primarily related to the number of injections. To the best of our knowledge, there are no reports of maintaining the best corrected visual acuity (BCVA) for more than 7 years in extension studies. OBJECTIVE: To report a 12-year follow-up of a real-world case of nAMD where BCVA was preserved from declining...
March 18, 2024: BMC Ophthalmology
https://read.qxmd.com/read/38490478/tear-cytokine-levels-are-reduced-in-patients-treated-with-intravitreal-injections
#10
JOURNAL ARTICLE
Agni Malmin, Vilde M Thomseth, Per T Førland, HansC D Aass, Sjur Reppe, Markus V Olsen, Birger Lindtjørn, Xiangjun Chen, IngaB K Haugen, Tor P Utheim, Vegard A Forsaa
PURPOSE: To investigate cytokine levels in the tear fluid of patients receiving serial intravitreal injections (IVI) with anti-vascular endothelial growth factor (anti-VEGF) for neovascular age-related macular degeneration (nAMD). METHODS: Concentrations of six cytokines (IFN-γ, IL-1β, IL-6, IL-8, TNF and VEGF) in tears of patients receiving anti-VEGF in one eye were assayed using multiplex cytometric bead array. The fellow untreated eye served as control...
March 13, 2024: Ocular Surface
https://read.qxmd.com/read/38489060/impact-of-prolonged-persisting-subretinal-fluid-on-the-outcome-of-aflibercept-treatment-in-neovascular-age-related-macular-degeneration
#11
JOURNAL ARTICLE
Ji Hyun Lee, Jae Hui Kim
Purpose: To evaluate the effect of prolonged residual subretinal fluid (SRF) on the outcomes of aflibercept treatment in neovascular age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV). Methods: This retrospective study included patients diagnosed with neovascular AMD or PCV who presented with fovea-involving residual SRF that persisted for a minimum of 6 months while undergoing aflibercept treatment. Changes in best-corrected visual acuity (BCVA) during persistent SRF were evaluated...
March 2024: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38488462/heimler-syndrome-with-a-complaint-of-blurred-vision-caused-by-compound-heterozygous-variants-in-pex1
#12
JOURNAL ARTICLE
Yanchen Zhang, Zhixing Li, Bing Lin, Xiaoling Liu, Zuhua Sun
INTRODUCTION: Heimler syndrome (HS) is a rare disorder that includes sensorineural hearing loss (SNHL), nail abnormalities, and enamel hypoplasia. Patients with this syndrome can also exhibit ocular manifestations. At present, only a few cases of HS have been reported, existing knowledge of this syndrome is limited, and many cases have been misdiagnosed or even missed. This is the first report of Heimler syndrome with blurred vision as the first complaint, which was diagnosed by genetic analysis in the ophthalmology department...
March 15, 2024: European Journal of Ophthalmology
https://read.qxmd.com/read/38486642/impact-of-coronavirus-disease-2019-on-intravitreal-antivascular-endothelial-growth-factor-injection-rates-in-nigerians
#13
JOURNAL ARTICLE
Ogugua Ndubuisi Okonkwo, Adekunle Olubola Hassan, Tayo Bogunjoko, Ayodele Akinye, Toyin Akanbi, Chineze Agweye
AIM: To quantify the impact of coronavirus disease 2019 (COVID-19) on the rate of intravitreal antivascular endothelial growth factor (VEGF) injections (IVI) in eye hospitals in Nigeria. MATERIALS AND METHODS: A retrospective, observational, comparative study. The IVIs given 12 months before (pre-COVID) and 12 months after the first announcement of the COVID-19 lockdown (COVID) in Nigeria in four hospitals were used as the sample for this study. All eyes were treatment naïve...
2024: Journal of the West African College of Surgeons
https://read.qxmd.com/read/38485215/using-artificial-intelligence-to-improve-human-performance-efficient-retinal-disease-detection-training-with-synthetic-images
#14
JOURNAL ARTICLE
Hitoshi Tabuchi, Justin Engelmann, Fumiatsu Maeda, Ryo Nishikawa, Toshihiko Nagasawa, Tomofusa Yamauchi, Mao Tanabe, Masahiro Akada, Keita Kihara, Yasuyuki Nakae, Yoshiaki Kiuchi, Miguel O Bernabeu
BACKGROUND: Artificial intelligence (AI) in medical imaging diagnostics has huge potential, but human judgement is still indispensable. We propose an AI-aided teaching method that leverages generative AI to train students on many images while preserving patient privacy. METHODS: A web-based course was designed using 600 synthetic ultra-widefield (UWF) retinal images to teach students to detect disease in these images. The images were generated by stable diffusion, a large generative foundation model, which we fine-tuned with 6285 real UWF images from six categories: five retinal diseases (age-related macular degeneration, glaucoma, diabetic retinopathy, retinal detachment and retinal vein occlusion) and normal...
March 14, 2024: British Journal of Ophthalmology
https://read.qxmd.com/read/38485112/saffron-therapy-for-the-ongoing-treatment-of-age-related-macular-degeneration
#15
JOURNAL ARTICLE
Geoffrey K Broadhead, John Grigg, Peter J McCluskey, Thomas Hong, Timothy E Schlub, Eugenia Chu, Andrew A Chang
OBJECTIVE: To assess the long-term efficacy and safety of oral saffron, a natural antioxidant, in treating mild/moderate age-related macular degeneration (AMD). METHODS AND ANALYSIS: Open-label, extension trial of 93 adults (>50 years) with mild/moderate AMD and vision >20/70 Snellen equivalent in at least 1 eye. Exclusion criteria included confounding visual lesions or significant gastrointestinal disease impairing absorption.Participants were given oral saffron supplementation (20 mg/day) for 12 months...
March 13, 2024: BMJ Open Ophthalmology
https://read.qxmd.com/read/38484787/long-term-follow-up-and-regeneration-of-retinal-pigment-epithelium-rpe-after-tears-of-the-epithelium-in-exudative-age-related-macular-degeneration-amd
#16
JOURNAL ARTICLE
Nicolas Skalicky, Katja Hatz-Wurziger
BACKGROUND: The goals of this study are to evaluate potential long-term visual deterioration associated with retinal pigment epithelial (RPE) tears in patients with neovascular age-related macular degeneration (nAMD) and to find treatment-related and morphological factors that might influence the outcomes. PATIENTS AND METHODS: This retrospective study enrolled 21 eyes of 21 patients from the database of Vista Eye Clinic Binningen, Switzerland, diagnosed with RPE tears, as confirmed by spectral domain optical coherence tomography (SD-OCT), with a minimum follow-up period of 12 months...
March 14, 2024: Klinische Monatsblätter Für Augenheilkunde
https://read.qxmd.com/read/38484366/identification-of-key-lncrnas-in-age-related-macular-degeneration-through-integrated-bioinformatics-and-experimental-validation
#17
JOURNAL ARTICLE
Yuying Ji, Chengguo Zuo, Nanying Liao, Liwei Yao, Ruijun Yang, Hui Chen, Feng Wen
This study aimed to identify key long noncoding RNAs (lncRNAs) in age-related macular degeneration (AMD) patients and to identify relevant pathological mechanisms of AMD development. We identified 407 differentially expressed mRNAs and 429 differentially expressed lncRNAs in retinal pigment epithelium (RPE) and retina in the macular region of AMD patients versus controls (P < 0.05 and |log2FC| > 0.585) from GSE135092. A total of 14 key differentially expressed mRNAs were obtained through external data validation from GSE115828...
March 14, 2024: Aging
https://read.qxmd.com/read/38483688/can-objective-parameters-in-optical-coherence-tomography-be-useful-markers-in-the-treatment-and-follow-up-of-type-1-and-type-2-macular-neovascularizations-related-to-neovascular-age-related-macular-degeneration
#18
JOURNAL ARTICLE
Osman Özen, Ayşe Gül Koçak Altıntaş
PURPOSE: The aim of this study was to compare the responses of type 1 and type 2 macular neovascularizations (MNV) caused by neovascular type age-related macular degeneration (n-AMD) to intravitreal anti-vascular endothelial growth factor (VEGF) treatments using quantitative parameters determined by optical coherence tomography (OCT). Additionally, it was also intended to assess the connections between these quantitative parameters and changes in best-corrected visual acuity (BCVA) and the number of intravitreal anti-VEGF injections required within a year...
March 14, 2024: International Ophthalmology
https://read.qxmd.com/read/38483610/comparing-2-dimensional-macular-pigment-optical-density-with-objective-and-subjective-perimetry-and-visual-acuity-in-age-related-macular-degeneration
#19
JOURNAL ARTICLE
Bhim B Rai, Faran Sabeti, Joshua P van Kleef, Corinne F Carle, Emilie M F Rohan, Rohan W Essex, Richard C Barry, Ted Maddess
PURPOSE: To compare diagnostic power for different severities of age-related macular degeneration (AMD) of two-dimensional macular pigment optical densities (2D-MPOD) and spatially matched objective perimetry, with standard perimetry and best-corrected visual acuity (BCVA). METHODS: The ObjectiveField Analyser (OFA) provided objective perimetry, and a Heidelberg Spectralis optical coherence tomography (OCT) measured 2D-MPOD in AMD patients, both completed twice over 0...
March 14, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38483382/phase-2-trial-evaluating-minocycline-for-geographic-atrophy-in-age-related-macular-degeneration-a-nonrandomized-controlled-trial
#20
JOURNAL ARTICLE
Tiarnan D L Keenan, Clare Bailey, Maria Abraham, Christine Orndahl, Supriya Menezes, Sunil Bellur, Thilaka Arunachalam, Cathy Kangale-Whitney, Sowmya Srinivas, Ayesha Karamat, Muneeswar Nittala, Denise Cunningham, Brett G Jeffrey, Henry E Wiley, Alisa T Thavikulwat, SriniVas Sadda, Catherine A Cukras, Emily Y Chew, Wai T Wong
IMPORTANCE: Existing therapies to slow geographic atrophy (GA) enlargement in age-related macular degeneration (AMD) have relatively modest anatomic efficacy, require intravitreal administration, and increase the risk of neovascular AMD. Additional therapeutic approaches are desirable. OBJECTIVE: To evaluate the safety and possible anatomic efficacy of oral minocycline, a microglial inhibitor, for the treatment of GA in AMD. DESIGN, SETTING, AND PARTICIPANTS: This was a phase 2, prospective, single-arm, 45-month, nonrandomized controlled trial conducted from December 2016 to April 2023...
March 14, 2024: JAMA Ophthalmology
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