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https://www.readbyqxmd.com/read/28731053/oct-angiography-documented-reperfusion-of-translocated-autologous-full-thickness-rpe-choroid-graft-for-complicated-neovascular-age-related-macular-degeneration
#1
M Veckeneer, C Augustinus, E Feron, P-P Schauwvlieghe, J Ruys, I Cosemans, J Van Meurs
PurposeThe purpose of this study is to investigate the reperfusion of translocated retinal pigment epithelium (RPE)-choroid graft in the treatment of patients with neovascular age-related macular degeneration (nAMD), using OCT angiography (OCTA), a novel non-invasive, high-resolution imaging modality.Patients and methodsEighteen eyes of 18 consecutive patients suffering from complicated nAMD underwent RPE-choroid patch graft translocation surgery using a peripheral retinotomy and flap-over technique. We analyzed functional and anatomical outcome using visual acuity, Spectral Domain OCT and OCTA...
July 21, 2017: Eye
https://www.readbyqxmd.com/read/28731052/real-world-visual-acuity-outcomes-between-ranibizumab-and-aflibercept-in-treatment-of-neovascular-amd-in-a-large-us-data-set
#2
A Lotery, R Griner, A Ferreira, F Milnes, P Dugel
PurposeTo examine 12-month real-world visual acuity outcomes and treatment patterns in neovascular age-related macular degeneration (nAMD) eyes, including those with pigment epithelial detachment (PED), receiving ranibizumab or aflibercept.Patients and methodsElectronic medical records were used to identify ranibizumab or aflibercept-treated nAMD eyes with 12 months follow-up from first prescription. The primary objective was to compare mean change in visual acuity (VA) between index and month 12, in eyes treated with ranibizumab and aflibercept to assess the non-inferiority of ranibizumab vs aflibercept using a -5 letter non-inferiority margin...
July 21, 2017: Eye
https://www.readbyqxmd.com/read/28730556/stem-cell-derived-retinal-pigment-epithelium-the-role-of-pigmentation-as-maturation-marker-and-gene-expression-profile-comparison-with-human-endogenous-retinal-pigment-epithelium
#3
A Bennis, J G Jacobs, L A E Catsburg, J B Ten Brink, C Koster, R O Schlingemann, J van Meurs, T G M F Gorgels, P D Moerland, V M Heine, A A Bergen
In age-related macular degeneration (AMD) the retinal pigment epithelium (RPE) deteriorates, leading to photoreceptor decay and severe vision loss. New therapeutic strategies aim at RPE replacement by transplantation of pluripotent stem cell (PSC)-derived RPE. Several protocols to generate RPE have been developed where appearance of pigmentation is commonly used as indicator of RPE differentiation and maturation. It is, however, unclear how different pigmentation stages reflect developmental stages and functionality of PSC-derived RPE cells...
July 21, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28730106/mitochondrial-expression-and-activity-of-p-glycoprotein-under-oxidative-stress-in-outer-blood-retinal-barrier
#4
Yue-Hong Zhang, Juan Li, Wei-Zhong Yang, Zhuan-Hua Xian, Qi-Ting Feng, Xiang-Cai Ruan
AIM: To investigate the role of oxidative stress in regulating the functional expression of P-glycoprotein (P-gp) in mitochondria of D407 cells. METHODS: D407 cells were exposed to different ranges of concentrations of H2O2. The mitochondrial location of P-gp in the cells subjected to oxidative stress was detected by confocal analysis. Expression of P-gp in isolated mitochondria was assessed by Western blot. The pump activity of P-gp was evaluated by performing the efflux study on isolated mitochondria with Rhodamine 123 (Rho-123) alone and in the presence of P-gp inhibitor (Tariquidar) using flow cytometry analysis...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28729948/algorithms-for-the-automated-analysis-of-age-related-macular-degeneration-biomarkers-on-optical-coherence-tomography-a-systematic-review
#5
REVIEW
Maximilian W M Wintergerst, Thomas Schultz, Johannes Birtel, Alexander K Schuster, Norbert Pfeiffer, Steffen Schmitz-Valckenberg, Frank G Holz, Robert P Finger
PURPOSE: To assess the quality of optical coherence tomography (OCT) grading algorithms for retinal biomarkers of age-related macular degeneration (AMD). METHODS: Following a systematic review of the literature data on detection and quantification of AMD retinal biomarkers by available algorithms were extracted and descriptively synthesized. Algorithm quality was assessed using a modified version of the Quality Assessment of Diagnostic Accuracy Studies 2 checklist with a focus on accuracy against established reference standards and risk of bias...
July 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28729371/geographic-atrophy-phenotype-identification-by-cluster-analysis
#6
Jordi Monés, Marc Biarnés
BACKGROUND/AIMS: To identify ocular phenotypes in patients with geographic atrophy secondary to age-related macular degeneration (GA) using a data-driven cluster analysis. METHODS: This was a retrospective analysis of data from a prospective, natural history study of patients with GA who were followed for ≥6 months. Cluster analysis was used to identify subgroups within the population based on the presence of several phenotypic features: soft drusen, reticular pseudodrusen (RPD), primary foveal atrophy, increased fundus autofluorescence (FAF), greyish FAF appearance and subfoveal choroidal thickness (SFCT)...
July 20, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28724817/real-world-evidence-of-safety-profile-of-intravitreal-bevacizumab-avastin-in-an-indian-scenario
#7
Prashant Jain, Jay Sheth, Giridhar Anantharaman, Mahesh Gopalakrishnan
PURPOSE: The purpose of this study was to evaluate the safety profile of intravitreal bevacizumab (Avastin) as an off-label pharmacotherapeutic agent for various ocular conditions. METHODS: Retrospective analysis was carried out on 3806 injections of 1761 patients that were administered with intravitreal bevacizumab injection at a tertiary eye care center in India. The injections were administered on a pro re nata basis for various indications such as age-related macular degeneration (AMD), diabetic macular edema (DME), and retinal vein occlusion (RVO)...
July 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28723848/progression-of-macular-atrophy-in-eyes-with-type-1-neovascularization-and-age-related-macular-degeneration-receiving-long-term-intravitreal-anti-vascular-endothelial-growth-factor-therapy-an-optical-coherence-tomographic-angiography-analysis
#8
Joseph G Christenbury, Nopasak Phasukkijwatana, Fatimah Gilani, K Baily Freund, SriniVas Sadda, David Sarraf
PURPOSE: To evaluate the size and location of macular atrophy in eyes with Type-1 neovascularization (NV) and age-related macular degeneration receiving chronic intravitreal anti-vascular endothelial growth factor therapy. METHODS: A retrospective review of a case series of 27 eyes with Type-1 NV and retinal pigment epithelial detachment (PED) having a minimum of 12 months follow-up was performed. Demographic information and visual acuity at baseline and the final follow-up were collected...
July 18, 2017: Retina
https://www.readbyqxmd.com/read/28721006/incidence-of-outer-retinal-tubulation-in-eyes-with-choroidal-neovascularization-under-intravitreal-anti-vascular-endothelial-growth-factor-therapy-in-a-japanese-population
#9
Seiji Takagi, Michiko Mandai, Noriko Miyamoto, Akihiro Nishida, Yasuhiko Hirami, Hirofumi Uyama, Midori Yamamoto, Masayo Takahashi, Goji Tomita, Yasuo Kurimoto
PURPOSE: The purpose of this study was to investigate the occurrence of outer retinal tubulation (ORT) among patients with different types of choroidal neovascularization (CNV) over time. MATERIALS AND METHODS: In this retrospective chart review, disease type was classified as typical age-related macular degeneration (t-AMD), polypoidal choroidal vasculopathy (PCV), retinal angiomatous proliferation (RAP), or myopic CNV (mCNV). Spectral domain-optical coherence tomography (SD-OCT) images were evaluated for the appearance of ORT and subretinal fibrosis and fluid...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28717807/vitamin-d-status-and-prevalent-early-age-related-macular-degeneration-in-african-americans-and-caucasians-the-atherosclerosis-risk-in-communities-aric-study
#10
A E Millen, J Nie, M W Sahli, J A Mares, K J Meyers, B E K Klein, M J LaMonte, P L Lutsey, C A Andrews, R Klein
OBJECTIVES: Vitamin D status has been hypothesized to protect against development of early age-related macular degeneration (AMD) via its anti-inflammatory properties and its possible beneficial influence on blood pressure control. We investigated the association between vitamin D status and prevalent early AMD in a community-based cohort. DESIGN: This was a cross-sectional study. SETTING: This was a secondary data analysis of already existing data from the Atherosclerosis Risk in Communities Study (ARIC) cohort collected from 1990 to 1995...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28715845/apatinib-an-inhibitor-of-vascular-endothelial-growth-factor-receptor-2-suppresses-pathologic-ocular-neovascularization-in-mice
#11
Koung Li Kim, Wonhee Suh
Purpose: Vascular endothelial growth factor (VEGF) signaling via VEGF receptor 2 (VEGFR2) plays a crucial role in pathologic ocular neovascularization. In this study, we investigated the antiangiogenic effect of apatinib, a pharmacologic inhibitor of VEGFR2 tyrosine kinase, against oxygen-induced retinopathy (OIR) and laser-induced choroidal neovascularization (CNV) in mice. Methods: Western blotting and in vitro angiogenesis assays were performed using human retinal microvascular endothelial cells (HRMECs)...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28715590/optical-coherence-tomography-features-preceding-the-onset-of-advanced-age-related-macular-degeneration
#12
Daniela Ferrara, Rachel E Silver, Ricardo N Louzada, Eduardo A Novais, Giliann K Collins, Johanna M Seddon
Purpose: Age-related macular degeneration (AMD) is a progressive disease with multifactorial etiology. There is a need to identify clinical features that are harbingers of advanced disease. We evaluated morphologic features of the retina and choroid on optical coherence tomography (OCT) to determine if they predict progression to advanced disease. Methods: Progressors transitioned from early or intermediate AMD to advanced disease (n = 40 eyes), and were matched on baseline AMD grade and follow-up interval to nonprogressors who did not develop advanced AMD (n = 40 eyes)...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28713647/evaluation-of-two-systems-for-fundus-controlled-scotopic-and-mesopic-perimetry-in-eye-with-age-related-macular-degeneration
#13
Julia S Steinberg, Marlene Saßmannshausen, Maximilian Pfau, Monika Fleckenstein, Robert P Finger, Frank G Holz, Steffen Schmitz-Valckenberg
PURPOSE: The purpose of this study was to evaluate and compare the MP-1S (Nidek Technologies, Padova, Italy) and the S-MAIA (CenterVue, Padova, Italy) for mesopic and scotopic fundus-controlled perimetry (FCP) in age-related macular degeneration (AMD). METHODS: Eleven eyes from 11 patients underwent mesopic and, after 30 minutes of dark adaptation, scotopic (MP-1S: Goldmann V, 200 ms, background luminance 0.0032 cd/m(2); S-MAIA: Goldman III, 200 ms, background luminance <0...
July 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28712657/prevalence-of-age-related-macular-degeneration-in-europe-the-past-and-the-future
#14
Johanna M Colijn, Gabriëlle H S Buitendijk, Elena Prokofyeva, Dalila Alves, Maria L Cachulo, Anthony P Khawaja, Audrey Cougnard-Gregoire, Bénédicte M J Merle, Christina Korb, Maja G Erke, Alain Bron, Eleftherios Anastasopoulos, Magda A Meester-Smoor, Tatiana Segato, Stefano Piermarocchi, Paulus T V M de Jong, Johannes R Vingerling, Fotis Topouzis, Catherine Creuzot-Garcher, Geir Bertelsen, Norbert Pfeiffer, Astrid E Fletcher, Paul J Foster, Rufino Silva, Jean-François Korobelnik, Cécile Delcourt, Caroline C W Klaver
PURPOSE: Age-related macular degeneration (AMD) is a frequent, complex disorder in elderly of European ancestry. Risk profiles and treatment options have changed considerably over the years, which may have affected disease prevalence and outcome. We determined the prevalence of early and late AMD in Europe from 1990 to 2013 using the European Eye Epidemiology (E3) consortium, and made projections for the future. DESIGN: Meta-analysis of prevalence data. PARTICIPANTS: A total of 42 080 individuals 40 years of age and older participating in 14 population-based cohorts from 10 countries in Europe...
July 14, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28707091/-fluorescein-indocyanine-green-and-optical-coherence-tomography-angiography-in-patients-with-native-exudative-age-related-macular-degeneration
#15
L J B Pauleikhoff, K Blobner, K Wehrmann, N Feucht, C P Lohmann, M Maier
INTRODUCTION: The newly developed optical coherence tomography angiography (OCT-A) has provided new means to depict the vascular plexus in neovascular age-related macular degeneration (nAMD). If these images are to be used as a basis for therapeutic decisions, it is of vital importance to classify choroidal neovascularization (CNV) as either classical or occult. This study aimed at comparing the findings in OCT-A imaging of CNV with the traditional multimodal imaging through fluorescein angiography (FLA) and indocyanine green angiography (ICGA)...
July 13, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28703135/genome-wide-association-study-of-neovascular-age-related-macular-degeneration-in-the-thai-population
#16
Paisan Ruamviboonsuk, Mongkol Tadarati, Panisa Singhanetr, Sukanya Wattanapokayakit, Punna Kunhapan, Thanyapat Wanitchanon, Nuanjun Wichukchinda, Taisei Mushiroda, Masato Akiyama, Yukihide Momozawa, Michiaki Kubo, Surakameth Mahasirimongkol
We performed a genome-wide association study on 377 cases of neovascular age-related macular degeneration (AMD) and 1074 controls to determine the association of previously reported genetic variants associated with neovascular AMD in the Thai population. All patients were of Thai ancestry. We confirmed the association of age-related maculopathy susceptibility 2 (ARMS2) rs10490924 (P=7.38 × 10(-17)), HTRA1 rs11200638 (P=5.47 × 10(-17)) and complement factor H gene (CFH) rs800292 (P=2.53 × 10(-8)) with neovascular AMD, all loci passing the genome-wide significance level (P<5...
July 13, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28697703/retrospective-analysis-of-the-effect-of-aflibercept-loading-dose-on-the-retinal-vessel-diameters-in-patients-with-treatment-naive-neovascular-amd
#17
Mehmet Tetikoğlu, Muhammed Mustafa Kurt, Hacı Murat Sağdık, Serdar Aktaş, Medine Aslı Yıldırım, Fatih Özcura
BACKGROUND: To evaluate the effects of intravitreal aflibercept (IVA) on retinal vessel diameters in patients with neovascular age-related macular degeneration (AMD). DESIGN, SETTING, AND PARTICIPANTS: A retrospective study conducted at the Kutahya Dumlupinar University Faculty of Medicine included fifteen eyes of fifteen patients with treatment naive neovascular AMD. METHODS: All eyes received IVA injections once per month for 3 months; untreated contralateral eyes were used as controls...
July 11, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28691893/sleep-and-mood-changes-in-advanced-age-after-blue-blocking-yellow-intra-ocular-lens-iols-implantation-during-cataract-surgical-treatment-a-randomized-controlled-trial
#18
Olivia Zambrowski, Elsa Tavernier, Eric H Souied, Thomas Desmidt, Amélie Le Gouge, David Bellicaud, Béatrice Cochener, Nadège Limousin, Caroline Hommet, Elisabeth Autret-Leca, Pierre-Jean Pisella, Vincent Camus
OBJECTIVES: Both advanced age and depression are characterized by changes in sleep patterns. Light exposure is one of the main synchronizers of circadian cycles and influences sleep by inhibiting melatonin secretion, which is mostly sensitive to light of low wavelengths (blue). Blue-blocking (yellow) intraocular lenses (IOLs) have supplanted the usual UV-blocking (clear) IOLs during cataract surgery to prevent age-related macular degeneration, however, the impact of yellow IOLs on sleep and mood is unclear...
July 10, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28689897/the-prevalence-and-causes-of-vision-loss-in-indigenous-and-non-indigenous-australians-the-national-eye-health-survey
#19
Joshua Foreman, Jing Xie, Stuart Keel, Peter van Wijngaarden, Sukhpal Singh Sandhu, Ghee Soon Ang, Jennifer Fan Gaskin, Jonathan Crowston, Rupert Bourne, Hugh R Taylor, Mohamed Dirani
PURPOSE: To conduct a nationwide survey on the prevalence and causes of vision loss in Indigenous and non-Indigenous Australians. DESIGN: Nationwide, cross-sectional, population-based survey. PARTICIPANTS: Indigenous Australians aged 40 years or older and non-Indigenous Australians aged 50 years and older. METHODS: Multistage random-cluster sampling was used to select 3098 non-Indigenous Australians and 1738 Indigenous Australians from 30 sites across 5 remoteness strata (response rate of 71...
July 6, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28689178/sacubitril-valsartan-beyond-natriuretic-peptides
#20
REVIEW
Jagdeep S S Singh, Louise M Burrell, Myriam Cherif, Iain B Squire, Andrew L Clark, Chim C Lang
Natriuretic peptides, especially B-type natriuretic peptide (BNP), have primarily been regarded as biomarkers in heart failure (HF). However, they are also possible therapeutic agents due to their potentially beneficial physiological effects. The angiotensin receptor-neprilysin inhibitor, sacubitril/valsartan, simultaneously augments the natriuretic peptide system (NPS) by inhibiting the enzyme neprilysin (NEP) and inhibits the renin-angiotensin-aldosterone system (RAAS) by blocking the angiotensin II receptor...
July 8, 2017: Heart: Official Journal of the British Cardiac Society
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