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https://www.readbyqxmd.com/read/29148027/sequential-tissue-plasminogen-activator-pneumatic-displacement-and-anti-vegf-treatment-for-submacular-hemorrhage
#1
Handan Bardak, Yavuz Bardak, Yeşim Erçalık, Burak Erdem, Gökhan Arslan, Semrin Timlioglu
PURPOSE: To report the results of our sequential intravitreal (IV) tissue plasminogen activator (tPA), pneumatic displacement (PD), and IV anti-vascular endothelial growth factor (VEGF) treatment in patients with neovascular age-related macular degeneration (nAMD)-related submacular hemorrhage (SMH). METHODS: A total of 16 eyes of 16 patients with SMH of less than 15 days duration were included in this retrospective pilot study. The tPA was applied on the day of diagnosis, and PD was performed the following day...
November 4, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29146306/real-world-vision-in-age-related-macular-degeneration-patients-treated-with-single-anti-vegf-drug-type-for-1-year-in-the-iris-registry
#2
Prethy Rao, Flora Lum, Kevin Wood, Craig Salman, Bhavya Burugapalli, Rebecca Hall, Sukhminder Singh, David W Parke, George A Williams
PURPOSE: The purpose of this study is to compare real-world visual acuity (VA) in patients with neovascular age-related macular degeneration (nAMD) treated with a single anti-vascular endothelial growth factor (VEGF) drug monotherapy for 1 year from the American Academy of Ophthalmology (AAO) Intelligent Research in Sight (IRIS) Registry. DESIGN: Retrospective, nonrandomized, comparative study. PARTICIPANTS: IRIS Registry patients with nAMD who received bevacizumab, ranibizumab, or aflibercept only for 1 year between 2013-2016...
November 13, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29145636/localization-and-functional-characterization-of-the-p-asn965ser-n965s-abca4-variant-in-mice-reveal-pathogenic-mechanisms-underlying-stargardt-macular-degeneration
#3
Laurie L Molday, Daniel Wahl, Marinko Sarunic, Robert S Molday
ABCA4 is a member of the superfamily of ATP-binding cassette (ABC) proteins that transports N-retinylidene-phosphatidylethanolamine (N-Ret-PE) across outer segment disc membranes thereby facilitating the removal of potentially toxic retinoid compounds from photoreceptor cells. Mutations in the gene encoding ABCA4 are responsible for Stargardt disease (STGD1), an autosomal recessive retinal degenerative disease that causes severe vision loss. To define the molecular basis for STGD1 associated with the p.Asn965Ser (N965S) mutation in the Walker A motif of nucleotide binding domain 1 (NBD1), we generated a p...
November 14, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29138977/-reasons-for-delayed-and-discontinued-therapy-in-age-related-macular-degeneration
#4
M W M Wintergerst, J Bouws, J Loss, B Heimes, D Pauleikhoff, F G Holz, R P Finger
BACKGROUND: Critical prerequisites for successful therapy of neovascular age-related macular degeneration (nvAMD) are an early initiation and continuous monitoring; however, delays in starting therapy and non-medically indicated discontinuation of therapy are frequent, which limits therapy efficacy and, thus, visual outcomes. OBJECTIVE: To identify the reasons for delay in therapy and non-medically indicated termination of therapy. MATERIAL AND METHODS: Patients who had started a new therapy (starters) and those who independently terminated therapy (dropouts) were interviewed by telephone with a specific, standardized questionnaire...
November 14, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29135888/exit-strategy-in-a-treat-and-extend-regimen-for-exudative-age-related-macular-degeneration
#5
Petra Arendt, Siqing Yu, Marion R Munk, Andreas Ebneter, Sebastian Wolf, Martin S Zinkernagel
PURPOSE: To evaluate the outcome of an exit strategy in a treat-and-extend regimen for neovascular age-related macular degeneration. METHODS: Five hundred and ninety-eight eyes of 488 patients with neovascular age-related macular degeneration receiving intravitreal anti-vascular endothelial growth factor injections according to a treat-and-extend regimen were included in this retrospective study. A treat-and-extend regimen with either interval extension by 2 weeks or shortening by 1 week was used...
November 9, 2017: Retina
https://www.readbyqxmd.com/read/29135798/vitrectomy-with-subretinal-tissue-plasminogen-activator-and-gas-tamponade-for-subfoveal-hemorrhage-prognostic-factors-and-clinical-outcomes
#6
David J A Plemel, Steven R J Lapere, Christopher J Rudnisky, Matthew T S Tennant
PURPOSE: To study the prognostic factors and clinical outcomes of patients who underwent pars plana vitrectomy, subretinal injection of tissue plasminogen activator, and gas tamponade for the treatment of subfoveal hemorrhage (SFH). METHODS: A retrospective noncomparative interventional case series. RESULTS: Seventy-eight eyes from 77 patients were included. A total of 84.6% of eyes developed SFH from age-related macular degeneration. Partial or complete displacement of the SFH was achieved in 91...
November 10, 2017: Retina
https://www.readbyqxmd.com/read/29135322/retinal-structure-in-pre-clinical-age-related-macular-degeneration
#7
S Nusinowitz, Y Wang, P Kim, S Habib, R Baron, Y Conley, M Gorin
PURPOSE: To determine, if there are identifiable retinal structural changes associated with genetic risk for age-related macular degeneration (AMD). MATERIALS AND METHODS: Seventy-three subjects (range 51.5 to 68.9 years) participated in this prospective study. Subjects were recruited based on the presence of a family history of AMD in one or both parents. All participants underwent a complete ophthalmic exam and imagery for staging of disease severity and genetic testing to assess genetic risk for AMD development...
November 14, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29133652/hospital-anxiety-and-depression-scale-assessment-of-100-patients-before-and-after-using-low-vision-care-a-prospective-study-in-a-tertiary-eye-care-setting
#8
Pukhraj Rishi, Ekta Rishi, Aditya Maitray, Ashutosh Agarwal, Sridevi Nair, Sarika Gopalakrishnan
PURPOSE: Assessment of anxiety and depression in patients attending low vision care (LVC) using Hospital Anxiety and Depression Scale (HADS). METHODS: In this prospective, observational study, 100 patients with best-corrected visual acuity (BCVA) worse than 6/18 in the better eye or limitation of field of vision to <10° from center of fixation were assessed on the depression and anxiety subscales of HADS questionnaire before and after LVC. HADS is a 14-item scale with seven items each for anxiety and depression subscales...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29132549/association-of-copy-number-variations-in-complement-factor-h-related-genes-among-age-related-macular-degenerative-subjects
#9
Norshakimah Md Bakri, Vasudevan Ramachandran, Hoo Fan Kee, Visvaraja Subrayan, Hazlita Isa, Nor Fariza Ngah, Nur Afiqah Mohamad, Ching Siew Mooi, Chan Yoke Mun, Patimah Ismail, Fazliana Ismail, Erma Suryana Sukiman, Wan Alia Wan Sulaiman
Age-related macular degeneration (AMD) is the most widely recognised cause of irreversible vision loss and previous studies have suggested that the advancement of wet AMD is influenced by both modifiable and non-modifiable elements. Single nucleotide polymorphism (SNPs) and copy number of variations (CNVs) have been associated with AMD in various populations, however the results are conflicting. Our aim is to determine the CNVs of Complement Factor H-Related genes among Malaysian subjects with wet AMD. 130 patients with wet AMD and 120 healthy controls were included in this research...
December 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29131696/risk-factors-for-discontinuation-of-treatment-for-neovascular-age-related-macular-degeneration
#10
Inger Westborg, Aldana Rosso
PURPOSE: To investigate risk factors for treatment discontinuation for neovascular age-related macular degeneration (nAMD). METHODS: Data from the Swedish Macula Register and the Skåne Healthcare Register are reported on the treatment received by 932 nAMD patients diagnosed 2013-2015. Treatment discontinuation is defined as having a termination visit or lacking a control or treatment visit during the period of 10-14 months after the diagnostic visit. The risk of treatment discontinuation during the first year is estimated using a Poisson model and a classification tree...
November 13, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/29131493/gaming-to-improve-vision-21-st-century-self-monitoring-for-patients-with-age-related-macular-degeneration
#11
Hessom Razavi, Elizabeth Baglin, Pyrawy Sharangan, Emily Caruso, Nicole Tindill, Susan Griffin, Robyn Guymer
IMPORTANCE: Improved vision self-monitoring tools are required for people at risk of neovascular complications from age related macular degeneration (AMD). BACKGROUND: To report the self-monitoring habits of participants with intermediate AMD using the Amsler grid chart, and the use of personal electronic devices and gameplay in this over 50 year old cohort. DESIGN: Single-centre descriptive study carried out at the Centre for Eye Research (CERA), Melbourne, Australia...
November 13, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29117065/reduced-ganglion-cell-volume-on-optical-coherence-tomography-in-patients-with-geographic-atrophy
#12
Hema L Ramkumar, Brian Nguyen, Dirk-Uwe Bartsch, Luke J Saunders, Ilkay Kilic Muftuoglu, Qisheng You, William R Freeman
PURPOSE: Geographic atrophy (GA) is the sequelae of macular degeneration. Automated inner retinal analysis using optical coherence tomography is flawed because segmentation software is calibrated for normal eyes. The purpose of this study is to determine whether ganglion cell layer (GCL) volume is reduced in GA using manual analysis. METHODS: Nineteen eyes with subfoveal GA and 22 controls were selected for morphometric analyses. Heidelberg scanning laser ophthalmoscope optical coherence tomography images of the optic nerve and macula were obtained, and the Viewing Module was used to manually calibrate retinal layer segmentation...
November 7, 2017: Retina
https://www.readbyqxmd.com/read/29115893/the-impact-of-epiretinal-membrane-in-neovascular-age-related-macular-degeneration-treatment-a-spectral-domain-optical-coherence-tomography-study
#13
Irini Chatziralli, Panagiotis Stavrakas, George Theodossiadis, Konstantinos Ananikas, Eleni Dimitriou, Panagiotis Theodossiadis
PURPOSE: The purpose of this prospective study was to evaluate the impact of epiretinal membrane (ERM) on anatomical and functional results in patients with wet age-related macular degeneration (AMD) treated with intravitreal anti-vascular endothelial growth (anti-VEGF) injections. METHODS: Participants in the study were 48 patients with either wet AMD alone (AMD group, n = 27) or AMD and ERM (AMD/ERM group, n = 21). All patients received intravitreal anti-VEGF injections (three monthly injections and PRN thereafter) and were followed up for at least 12 months...
November 8, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/29115605/genetic-variations-in-bestrophin%C3%A2-1-and-associated-clinical-findings-in-two-chinese-patients-with-juvenile%C3%A2-onset-and-adult%C3%A2-onset-best-vitelliform-macular-dystrophy
#14
Ying Lin, Tao Li, Chenghong Ma, Hongbin Gao, Chuan Chen, Yi Zhu, Bingqian Liu, Yu Lian, Ying Huang, Haichun Li, Qingxiu Wu, Xiaoling Liang, Chenjin Jin, Xinhua Huang, Jianhua Ye, Lin Lu
Best vitelliform macular dystrophy (BVMD) is a hereditary retinal disease characterized by the bilateral accumulation of large egg yolk‑like lesions in the sub‑retinal and sub‑retinal pigment epithelium spaces. Macular degeneration in BVMD can begin in childhood or adulthood. The variation in the age of onset is not clearly understood. The present study characterized the clinical characteristics of two Chinese patients with either juvenile‑onset BVMD or adult‑onset BVMD and investigated the underlying genetic variations...
October 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29113742/change-in-choroidal-thickness-after-intravitreal-injection-for-treatment-of-neovascular-age-related-macular-degeneration-ranibizumab-versus-aflibercept
#15
F Kaya
PURPOSE: To compare the changes in subfoveal choroidal thickness after intravitreal ranibizumab or aflibercept injections for neovascular age-related macular degeneration (nAMD). METHODS: In this retrospective study, 28 eyes with nAMD treated with 3 consecutive monthly injections of ranibizumab (IVR) and 24 eyes with nAMD treated with 3 consecutive monthly injections of aflibercept (IVA) between September 2012 and June 2016 were reviewed. The follow-up time was 6 months...
November 4, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29110124/-who-visits-an-ophthalmologist-and-how-often-results-of-the-german-nationwide-adult-health-survey-degs1
#16
A K Schuster, C Wolfram, B Bertram, N Pfeiffer
BACKGROUND: The prevalence of eye diseases increases in the second half of life, especially cataract, glaucoma and age-related macular degeneration. In this study we examined the influencing factors for visiting an ophthalmologist in the last 12 months. METHODS: Visits to an ophthalmologist's practice in the last 12 months and the frequency were surveyed in the German nationwide adult health survey wave 1 (DEGS1) study (baseline examination from 2008 to 2011, N = 7987, 52...
November 6, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29106914/geographic-and-demographic-variation-in-use-of-ranibizumab-versus-bevacizumab-for-neovascular-age-related-macular-degeneration-in-the-united-states
#17
Emily W Gower, Joshua D Stein, Nakul S Shekhawat, Shravani Mikkilineni, Taylor S Blachley, Nicholas M Pajewski
PURPOSE: To examine demographic and geographic variation in the use of ranibizumab and bevacizumab for the treatment of neovascular age-related macular degeneration (AMD) among Medicare beneficiaries. DESIGN: Retrospective cohort study. METHODS: Using a 100% sample of Medicare claims data, we evaluated Medicare beneficiaries (N = 195 812) with an index claim for neovascular AMD between July 1, 2006, and June 30, 2009, to determine whether beneficiaries first received ranibizumab or bevacizumab following initial diagnosis...
October 26, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29103961/high-resolution-imaging-in-male-germ-cell-associated-kinase-mak-related-retinal-degeneration
#18
Young Ju Lew, Nicholas Rinella, Jia Qin, Joanna Chiang, Anthony T Moore, Travis C Porco, Austin Roorda, Jacque L Duncan
PURPOSE: To describe the characteristics of MAK-related retinal degeneration using optical coherence tomography angiography (OCTA) and adaptive optics scanning laser ophthalmoscopy (AOSLO). DESIGN: Cross-sectional study. METHODS: Six patients with rod-cone degeneration and disease-causing mutations in MAK were evaluated with visual acuity, spectral domain OCT, confocal AOSLO and OCTA. Foveal avascular zone (FAZ) area, vessel densities and perfusion densities of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) in the central macula in all 6 patients were compared with 5 normal subjects...
November 2, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29103793/consensus-definition-for-atrophy-associated-with-age-related-macular-degeneration-on-oct-classification-of-atrophy-report-3
#19
Srinivas R Sadda, Robyn Guymer, Frank G Holz, Steffen Schmitz-Valckenberg, Christine A Curcio, Alan C Bird, Barbara A Blodi, Ferdinando Bottoni, Usha Chakravarthy, Emily Y Chew, Karl Csaky, Ronald P Danis, Monika Fleckenstein, K Bailey Freund, Juan Grunwald, Carel B Hoyng, Glenn J Jaffe, Sandra Liakopoulos, Jordi M Monés, Daniel Pauleikhoff, Philip J Rosenfeld, David Sarraf, Richard F Spaide, Ramin Tadayoni, Adnan Tufail, Sebastian Wolf, Giovanni Staurenghi
PURPOSE: To develop consensus terminology and criteria for defining atrophy based on OCT findings in the setting of age-related macular degeneration (AMD). DESIGN: Consensus meeting. PARTICIPANTS: Panel of retina specialists, image reading center experts, retinal histologists, and optics engineers. METHODS: As part of the Classification of Atrophy Meetings (CAM) program, an international group of experts surveyed the existing literature, performed a masked analysis of longitudinal multimodal imaging for a series of eyes with AMD, and reviewed the results of this analysis to define areas of agreement and disagreement...
November 2, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29101353/in-vivo-multimodal-imaging-of-drusenoid-lesions-in-rhesus-macaques
#20
Glenn Yiu, Eric Tieu, Christian Munevar, Brittany Wong, David Cunefare, Sina Farsiu, Laura Garzel, Jeffrey Roberts, Sara M Thomasy
Nonhuman primates are the only mammals to possess a true macula similar to humans, and spontaneously develop drusenoid lesions which are hallmarks of age-related macular degeneration (AMD). Prior studies demonstrated similarities between human and nonhuman primate drusen based on clinical appearance and histopathology. Here, we employed fundus photography, spectral domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF), and infrared reflectance (IR) to characterize drusenoid lesions in aged rhesus macaques...
November 3, 2017: Scientific Reports
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