keyword
MENU ▼
Read by QxMD icon Read
search

macular degeneration and p

keyword
https://www.readbyqxmd.com/read/28801615/choroidal-remodeling-in-age-related-macular-degeneration-and-polypoidal-choroidal-vasculopathy-a-12-month-prospective-study
#1
Daniel Shu Wei Ting, Yasuo Yanagi, Rupesh Agrawal, Hwei Yee Teo, Sophia Seen, Ian Yew San Yeo, Ranjana Mathur, Choi Mun Chan, Shu Yen Lee, Edmund Yick Mun Wong, Doric Wong, Tien Yin Wong, Gemmy Chui Ming Cheung
Choroid thinning occurs in age-related macular degeneration (AMD). However, it remains unclear whether the reduction is due to reduction in choroidal vessels or shrinkage of choroidal stroma, or both. The purpose of this study was to evaluate the changes of the choroidal vascular and stromal area in 118 patients with typical AMD (t-AMD) and polypoidal choroidal vasculopathy (PCV) over a 12-month period. We used spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging (EDI) mode to measure the subfoveal choroidal thickness (CT), central retinal thickness (CRT) and choroidal vascularity index (CVI - ratio of luminal area to total choroidal area)...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28801117/incidence-and-outcomes-of-infectious-and-noninfectious-endophthalmitis-after-intravitreal-injections-for-age-related-macular-degeneration
#2
Vincent Daien, Vuong Nguyen, Rohan W Essex, Nigel Morlet, Daniel Barthelmes, Mark C Gillies
PURPOSE: To assess the incidence, cumulative rate, and long-term outcomes of infectious and noninfectious endophthalmitis after intravitreal injections (IVTs) of anti-vascular endothelial growth factor (VEGF) agents. DESIGN: Database study, prospectively designed. PARTICIPANTS: Treatment-naïve eyes with neovascular age-related macular degeneration (nAMD) tracked by the Fight Retinal Blindness! (FRB!) registry that commenced anti-VEGF therapy between January 1, 2006, and November 30, 2016...
August 8, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28799562/ophthalmic-features-of-spinocerebellar-ataxia-type-7
#3
A Campos-Romo, E O Graue-Hernandez, L Pedro-Aguilar, J C Hernandez-Camarena, D Rivera-De la Parra, V Galvez, R Diaz, A Jimenez-Corona, J Fernandez-Ruiz
PurposeTo analyze the relation between ophthalmologic and motor changes in spinocerebellar ataxia type 7 (SCA7).Patients and methodsThis was a case series study. Sixteen SCA7 patients underwent a comprehensive ophthalmic examination, including ocular extrinsic motility testing, color vision test, and optical coherence tomography of the optic nerve and macula. Changes in the corneal endothelium, electroretinographic patterns, and a complete neurologic evaluation using the Scale for the Assessment and Rating of Ataxia (SARA) were evaluated...
August 11, 2017: Eye
https://www.readbyqxmd.com/read/28794612/investigation-of-associations-of-arms2-cd14-and-tlr4-gene-polymorphisms-with-wet-age-related-macular-degeneration-in-a-greek-population
#4
Antonia Sarli, Iosif Skalidakis, Aliki Velissari, Chryssanthi Koutsandrea, Maria Stefaniotou, Michael B Petersen, Christos Kroupis, George Kitsos, Marilita M Moschos
BACKGROUND: Age-related macular degeneration (AMD) is a multifactorial degenerative ocular disease that leads to loss of central vision. Functional gene polymorphisms have already been associated with the disease (for example, ARMS2 A69S, rs10490924). AIM: The goal of our study was to verify the correlation of the aforementioned ARMS2 variation with the disease, to examine, for the first time, the role of the CD14 C260T variation (rs2569190), and to investigate the association of two TLR4 polymorphisms (Asp299Gly or rs4986790 and Thr399Ile or rs4986791) in a Greek population with the wet form of AMD...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28783458/tele-ophthalmology-for-age-related-macular-degeneration-and-diabetic-retinopathy-screening-a-systematic-review-and-meta-analysis
#5
Atsushi Kawaguchi, Noha Sharafeldin, Aishwarya Sundaram, Sandy Campbell, Matthew Tennant, Christopher Rudnisky, Ezekiel Weis, Karim F Damji
BACKGROUND: To synthesize high-quality evidence to compare traditional in-person screening and tele-ophthalmology screening. METHODS: Only randomized controlled trials (RCTs) were included in this systematic review and meta-analysis. The intervention of interest was any type of tele-ophthalmology, including screening of diseases using remote devices. Studies involved patients receiving care from any trained provider via tele-ophthalmology, compared with those receiving equivalent face-to-face care...
August 7, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28781927/gait-characteristics-of-age-related-macular-degeneration-patients
#6
Varshini Varadaraj, Aleksandra Mihailovic, Rebecca Ehrenkranz, Stephen Lesche, Pradeep Y Ramulu, Bonnielin K Swenor
PURPOSE: To identify potential differences between age-related macular degeneration (AMD) patients and controls in fall-relevant gait characteristics. METHODS: Spatiotemporal gait characteristics using the GAITRite walkway were collected from 29 AMD patients and 20 controls, aged 60 to 90 years, at the Wilmer Eye Institute. Multiple linear regressions, controlling for age, sex, body mass index (BMI), and comorbidities were used to assess associations between gait characteristics and AMD...
July 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28777387/increased-levels-of-circulating-cd34-cells-in-neovascular-age-related-macular-degeneration-relation-with-clinical-and-oct-features
#7
Caner Kara, Pınar Ç Özdal, Emrullah Beyazyıldız, Nurgül E Özcan, Mehmet Y Teke, Gülden Vural, Faruk Öztürk
PURPOSE: To investigate the levels of circulating CD34+ stem cells in patients with neovascular type age-related macular degeneration (AMD) and its relation with clinical and optical coherence tomography (OCT) findings. METHODS: The study consisted of 55 patients: 28 patients (18 male and 10 female) with neovascular type AMD as a study group and 27 patients (12 male and 15 female) scheduled for cataract surgery as a control group. The level of CD34+ stem cells was measured by flow cytometry...
August 2, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28775256/a-genome-wide-association-study-identified-a-novel-genetic-loci-ston1-gtf2a1l-lhcgr-fshr-for-bilaterality-of-neovascular-age-related-macular-degeneration
#8
Kyoko Kawashima-Kumagai, Kenji Yamashiro, Munemitsu Yoshikawa, Masahiro Miyake, Gemmy Cheung Chui Ming, Qiao Fan, Jia Yu Koh, Masaaki Saito, Masako Sugahara-Kuroda, Maho Oishi, Yumiko Akagi-Kurashige, Isao Nakata, Hideo Nakanishi, Norimoto Gotoh, Akio Oishi, Hiroshi Tamura, Sotaro Ooto, Akitaka Tsujikawa, Yasuo Kurimoto, Tetsuju Sekiryu, Fumihiko Matsuda, Chiea-Chuen Khor, Ching-Yu Cheng, Tien Yin Wong, Nagahisa Yoshimura
Bilateral neovascular age-related macular degeneration (AMD) causes much more handicaps for patients than unilateral neovascular AMD. Although several AMD-susceptibility genes have been evaluated for their associations to bilaterality, genome-wide association study (GWAS) on bilaterality has been rarely reported. In the present study, we performed GWAS using neovascular AMD cases in East Asian. The discovery stage compared 581,252 single nucleotide polymorphisms (SNPs) between 803 unilateral and 321 bilateral Japanese cases but no SNP showed genome-wide significance, while SNPs at six regions showed P-value < 1...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28772268/baseline-optical-coherence-tomography-findings-as-outcome-predictors-after-switching-from-ranibizumab-to-aflibercept-in-neovascular-age-related-macular-degeneration-following-a-treat-and-extend-regimen
#9
Cengiz Türksever, Christian Prünte, Katja Hatz
PURPOSE: To evaluate outcome predictors of aflibercept in neovascular age-related macular degeneration pretreated with ranibizumab based on a treat-and-extend regimen (TER). METHODS: We performed a retrospective evaluation of 18-month follow-up of 45 consecutive patients with limited response to ranibizumab. RESULTS: At month 18, mean central retinal thickness and intraretinal fluid (IRF) height were significantly reduced. The recurrence-free treatment interval (RFTI) increased from 7...
August 4, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28771565/segmented-inner-plexiform-layer-thickness-as-a-potential-biomarker-to-evaluate-open-angle-glaucoma-dendritic-degeneration-of-retinal-ganglion-cell
#10
Eun Kyoung Kim, Hae-Young Lopilly Park, Chan Kee Park
PURPOSE: To evaluate the changes of retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), and ganglion cell-inner plexiform layer (GCIPL) thicknesses and compare structure-function relationships of 4 retinal layers using spectral-domain optical coherence tomography (SD-OCT) in macular region of glaucoma patients. METHODS: In cross-sectional study, a total of 85 eyes with pre-perimetric to advanced glaucoma and 26 normal controls were enrolled...
2017: PloS One
https://www.readbyqxmd.com/read/28769990/altered-activation-state-of-circulating-neutrophils-in-patients-with-neovascular-age-related-macular-degeneration
#11
Marie Krogh Nielsen, Sven Magnus Hector, Kelly Allen, Yousif Subhi, Torben Lykke Sørensen
BACKGROUND: Neutrophil dysfunction plays a key role in the development of diseases characterized by inflammation and angiogenesis. Here, we studied the systemic expression of neutrophil markers reflecting activation, adhesion, and resolution of inflammation in patients with neovascular age-related macular degeneration (AMD). RESULTS: This was a prospective case-control study of patients with neovascular AMD and age-matched healthy control individuals. Patients were recruited from an outpatient program, and control individuals were recruited amongst patients' relatives...
2017: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/28767736/cigarette-smoke-induced-autophagy-impairment-regulates-amd-pathogenesis-mechanisms-in-arpe-19-cells
#12
Viren Kumar Govindaraju, Manish Bodas, Neeraj Vij
Age related macular degeneration (AMD) is one of the leading causes of blindness. Genetics, environmental insult, and age-related factors all play a key role in altering proteostasis, the homeostatic process regulating protein synthesis, degradation and processing. These factors also play a role in the pathogenesis of AMD and it has been well established that cigarette smoking (CS) initiates AMD pathogenic mechanisms. The primary goal of this study is to elucidate whether CS can induce proteostasis/autophagy-impairment in retinal pigment epithelial (RPE) cells...
2017: PloS One
https://www.readbyqxmd.com/read/28765149/changes-in-multiple-cytokine-concentrations-in-the-aqueous-humour-of-neovascular-age-related-macular-degeneration-after-2-months-of-ranibizumab-therapy
#13
Shinichi Sakamoto, Hidenori Takahashi, Xue Tan, Yuji Inoue, Yoko Nomura, Yusuke Arai, Yujiro Fujino, Hidetoshi Kawashima, Yasuo Yanagi
PURPOSE: To determine changes in multiple cytokine concentrations in the anterior chamber during the induction phase of ranibizumab treatment in patients with neovascular age-related macular degeneration (AMD). METHODS: This prospective study included 48 treatment-naïve neovascular AMD eyes of 48 patients who received three consecutive monthly injections of ranibizumab at the Japan Community Health Care Organization Tokyo Shinjuku Medical Center between November 2010 and August 2012...
August 1, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28763559/adiponectin-mediates-dietary-omega-3-long-chain-polyunsaturated-fatty-acid-protection-against-choroidal-neovascularization-in-mice
#14
Zhongjie Fu, Raffael Liegl, Zhongxiao Wang, Yan Gong, Chi-Hsiu Liu, Ye Sun, Bertan Cakir, Samuel B Burnim, Steven S Meng, Chatarina Löfqvist, John Paul SanGiovanni, Ann Hellström, Lois E H Smith
Purpose: Neovascular age-related macular degeneration (AMD) is a major cause of legal blindness in the elderly. Diets with omega3-long-chain-polyunsaturated-fatty-acid (ω3-LCPUFA) correlate with a decreased risk of AMD. Dietary ω3-LCPUFA versus ω6-LCPUFA inhibits mouse ocular neovascularization, but the underlying mechanism needs further exploration. The aim of this study was to investigate if adiponectin (APN) mediated ω3-LCPUFA suppression of neovessels in AMD. Methods: The mouse laser-induced choroidal neovascularization (CNV) model was used to mimic some of the inflammatory aspect of AMD...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28761325/taxifolin-protects-rpe-cells-against-oxidative-stress-induced-apoptosis
#15
Xiaobin Xie, Jun Feng, Zefeng Kang, Shoukang Zhang, Lixia Zhang, Yan Zhang, Xuefei Li, Youzhi Tang
PURPOSE: Oxidative stress-induced damage to RPE cells has been suggested to be an important factor in the pathogenesis of age-related macular degeneration. Taxifolin, a flavonol, has been shown to exhibit significant antioxidant properties. The purpose of this study was to investigate the potential protective effects of taxifolin on RPE cells cultured under oxidative stress conditions and to elucidate the underlying mechanisms. METHODS: Human RPE (ARPE-19) cells were treated with different concentrations of taxifolin and 0...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28760679/amelioration-of-amyloid-%C3%AE-induced-retinal-inflammatory-responses-by-a-lxr-agonist-to901317-is-associated-with-inhibition-of-the-nf-%C3%AE%C2%BAb-signaling-and-nlrp3-inflammasome
#16
Chunyan Lei, Ru Lin, Jiaming Wang, Lifei Tao, Xinyu Fu, Yiguo Qiu, Bo Lei
Amyloid β (Aβ) is a pathogenic peptide associated with many neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. The retinal inflammation in response to Aβ is implicated in the pathogenesis of several ocular diseases including age-related macular degeneration, Alzheimer's-related optic neuropathy and glaucoma. In the present study, we found that a single intravitreal injection of oligomeric Aβ1-40 in mouse activated the NLRP3 inflammasome and the NF-κB signaling, induced the production of inflammatory cytokines including TNF-α and IL-6...
July 29, 2017: Neuroscience
https://www.readbyqxmd.com/read/28746191/whole-exome-sequencing-unveils-a-frameshift-mutation-in-cngb3-for-cone-dystrophy-a-case-report-of-an-indian-family
#17
Shashank Gupta, Amit Chaurasia, Ekta Pathak, Rajeev Mishra, Vidya Nair Chaudhry, Prashaant Chaudhry, Ashim Mukherjee, Mousumi Mutsuddi
RATIONALE: Genetic elucidation of cone-dominated retinal dystrophies in Indian subcontinent is much needed to identify and catalog underlying genetic defects. In this context, the present study recruited a consanguineous Indian family affected with autosomal recessive cone dystrophy (CD). Considering the huge genetic heterogeneity and recessive inheritance of the disease, we chose to dissect out causal variant in this family by whole exome sequencing (WES). PATIENT CONCERNS: In the recruited family, three of the six siblings had complaints of poor visual acuity, photophobia, and disturbed colour vision since early childhood...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28740360/visual-processing-in-patients-with-age-related-macular-degeneration-performing-a-face-detection-test
#18
Pasi Vottonen, Kai Kaarniranta, Ari Pääkkönen, Ina M Tarkka
PURPOSE: People with age-related macular degeneration (AMD) have difficulties in familiar face recognition and facial expression discrimination. Our aim was to evaluate the visual processing of faces in AMD patients and whether this would be improved by anti-vascular endothelial growth factor therapy. This was a prospective interventional cohort study. PATIENTS: Twelve patients with monocular wet AMD and 6 control subjects were recruited. Face detection processes were studied using cortical event-related potentials (ERPs)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28738845/lutein-and-zeaxanthin-isomers-modulates-lipid-metabolism-and-the-inflammatory-state-of-retina-in-obesity-induced-high-fat-diet-rodent-model
#19
Mehmet Tuzcu, Cemal Orhan, Omer Ersin Muz, Nurhan Sahin, Vijaya Juturu, Kazım Sahin
BACKGROUND: Several studies associated high-fat intakes with a high incidence of age-related macular degeneration (AMD). Lutein and Zeaxanthin isomers (L/Zi) may counteract reactive oxygen species produced by oxidative stress. The present study was conducted to determine the possible effects of L/Zi administration on lipid profile, protein genes associated with oxidative stress and inflammation pathways in the obesity induced by a high-fat diet (HFD) in rodents. METHODS: Twenty-eight male Wistar rats were allocated into four groups as follows: (i) Control, (ii) Control + L/Zi, (iii) High Fat Diet (HFD), and (iv) HFD+ L/Z...
July 24, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28736371/-multifocal-electroretinography-for-therapeutic-effect-evaluation-of-intravitreal-injection-lucentis-for-wet-age-related-macular-degeneration
#20
Rui-Hong Ju, Man-Sha He, Jin-Tong Hou, Meng-Yuan Li, Jing-Lin Zhang, Zhe-Ming Wu
OBJECTIVE: To evaluate the changes in retinal functions using multifocal electroretinography (mfERG) following intravitreal injection of Lucentis for treatment of wet age-related macular degeneration. METHODS: This prospective study was conducted in 14 patients (9 men and 5 women, 14 eyes) with wet age-related macular degeneration receiving treatment with intravitreal injections of ranibizumab (Lucentis) in our hospital between October, 2014 and January, 2016. All the patients received the treatment following a 1+PRN protocol and after the initial injection, the patients were followed up monthly for 6 months to decide if additional injections were needed...
July 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
keyword
keyword
102809
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"