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Emma Bagshaw, David A Enoch, Michael Blackney, Jan Posthumus, Daniel Kuessner
AIM: Invasive mold diseases (IMDs) are associated with significant morbidity and mortality. Approved treatments include voriconazole (VORI), liposomal amphotericin B (L-AMB), posaconazole (POSA) and isavuconazole (ISAV). A UK-based economic model was developed to explore the cost of treating IMDs with ISAV versus L-AMB followed by POSA. MATERIALS & METHODS: As indirect comparisons have demonstrated similar efficacy between the comparators, a cost-minimization approach was taken...
June 18, 2018: Future Microbiology
Diego Gomes da Rocha Voris, Luciana Dos Santos Dias, Josélia Alencar Lima, Keila Dos Santos Cople Lima, José Bento Pereira Lima, Antônio Luís Dos Santos Lima
Aedes aegypti is the vector responsible for transmitting pathogens that cause various infectious diseases, such as dengue, Zika, yellow fever, and chikungunya, worrying health authorities in the tropics. Due to resistance of mosquitoes to synthetic insecticides, the search for more effective insecticidal agents becomes crucial. The aim of this study was to verify the larvicidal, adulticidal, and anticholinesterase activities of the essential oils of the Illicium verum (EOIV), Pimenta dioica (EOPD), and Myristica fragrans (EOMF) against Ae...
May 28, 2018: Environmental Science and Pollution Research International
Evan S H Quah, L Lee Grismer, Perry L Jr Wood, Myint Kyaw Thura, Thaw Zin, Htet Kyaw, Ngwe Lwin, Marta S Grismer, Matthew L Murdoch
A newly discovered species of homalopsid snake from the genus Gyiophis Murphy & Voris is described from the lowlands of Mawlamyine District in Mon state, southeastern Myanmar. Gyiophis salweenensis sp. nov. is presumed to be closely related to G. maculosa Blanford and G. vorisi Murphy based on the similarities in pholidosis and patterning but can be separated from G. maculosa by the shape of its first three dorsal scale rows that are square, ventral scale pattern that lacks a central spot, and a faint stripe on dorsal scale rows 1-4...
March 6, 2017: Zootaxa
Sandra Doß, Heike Potschka, Fanny Doß, Steffen Mitzner, Martin Sauer
Purpose. Drug-induced liver injury (DILI) is the most common cause of liver injury and a serious clinical problem; antimycotics are involved in approximately 3% of all DILI cases. The hepatotoxicity of many drugs, including the antimycotics, is poorly screened in human models. Methods. In a standardized assay the cytotoxicity on hepatocytes of different concentrations ( C max, 5x C max, and 10x C max) of the antimycotics used for systemic infections was tested. Anidulafungin (ANI), liposomal amphotericerin B (L-AmB), caspofungin (CASPO), fluconazole (FLUCO), and voriconazole (VORI) were incubated with HepG2/C3A cells...
2017: BioMed Research International
Bernard Scorneaux, David Angulo, Katyna Borroto-Esoda, Mahmoud Ghannoum, Michael Peel, Stephen Wring
SCY-078 is an orally bioavailable ß-1,3-glucan synthesis inhibitor (GSI) and the first-in-class of structurally novel triterpene antifungals in clinical development for treating candidemia and invasive candidiasis. In vitro susceptibilities by broth microdilution, antifungal carryover, and time-kill dynamics were determined for three reference (ATCC) strains (Candida albicans 90028, Candida parapsilosis 90018, and Candida tropicalis 750), a quality-control (QC) strain (Candida krusei 6258), and four other strains (C...
March 2017: Antimicrobial Agents and Chemotherapy
Olivier S G Pauwels, Montri Sumontha
In their revision of the homalopsid genus Homalopsis Kuhl & Van Hasselt, Murphy et al. (2012) resurrected H. semizonata Blyth, 1855 and noted that ''Frith (1977) reported on two Homalopsis from Phuket, Thailand with 40 and 42 dorsal scale rows, and 159 and 162 ventrals-scale counts within the range of H. semizonata which is found along the same coast, about 900 km to the north''. Murphy et al. (2012), however, did not list H. semizonata from Thailand, and on their species' distribution map they indicated an interrogation mark along the southern coast of Myanmar and the southwestern coast of peninsular Thailand...
May 2, 2016: Zootaxa
Leonardo Oliveira Reis, Juliano Cesar Moro, Luis Fernando Bastos Ribeiro, Brunno Raphael Iamashita Voris, Marcos Vinicius Sadi
OBJECTIVE: To evaluate the clinical practice of non-muscle invasive bladder cancer (NMIBC) treatment in Brazil in relation to international guidelines: Sociedade Brasileira de Urologia (SBU), European Association of Urology (EAU) and American Urological Association (AUA). METHODS: Cross-sectional study using questionnaires about urological practice on treatment of NMIBC during the 32nd Brazilian Congress of Urology. A total of 650 question forms were answered. RESULTS: There were 73% of complete answers (total of 476 question forms)...
January 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
M L Stock, L A Barth, N K Van Engen, S T Millman, R Gehring, C Wang, E A Voris, L W Wulf, Léa Labeur, W H Hsu, J F Coetzee
The objective of this study was to investigate the effects of carprofen administered immediately before cautery dehorning on nociception and stress. Forty Holstein calves aged approximately 6 to 8 wk old were either placebo treated and sham dehorned ( = 10) or cautery dehorned following administration of carprofen (1.4 mg/kg) subcutaneously ( = 10) or orally ( = 10) or a subcutaneous and oral placebo ( = 10) in a randomized, controlled trial. All animals were given a cornual nerve block using lidocaine before dehorning...
February 2016: Journal of Animal Science
George C Vorys, Hanying Bai, Chandhanarat Chandhanayingyong, Chang H Lee, Jocelyn T Compton, Jon-Michael Caldwell, Thomas R Gardner, Jeremy J Mao, Francis Y Lee
BACKGROUND: Large segmental bone defects following tumor resection, high-energy civilian trauma, and military blast injuries present significant clinical challenges. Tissue engineering strategies using scaffolds are being considered as a treatment, but there is little research into optimal fixation of such scaffolds. METHODS: Twelve fresh-frozen paired cadaveric legs were utilized to simulate a critical sized intercalary defect in the tibia. Poly-ε-caprolactone and hydroxyapatite composite scaffolds 5 cm in length with a geometry representative of the mid-diaphysis of an adult human tibia were fabricated, inserted into a tibial mid-diaphyseal intercalary defect, and fixed with a 14-hole large fragment plate...
December 2015: Clinical Biomechanics
Lihua Yang, Lihua Yu, Xinxin Chen, Yanqun Hu, Bin Wang
BACKGROUND: Vincristine (VCR) is a major chemotherapy drug for treatment of childhood acute lymphoblastic leukemia (ALL). Triazole antifungal drugs (AFD) are the main agents for the prevention/treatment of invasive fungal infection (IFI), a common complication during the treatment of ALL. This study investigated the adverse drug reactions (ADRs) between VCR and AFD. MATERIAL AND METHODS: A retrospective study was performed on 68 children with ALL (39 boys and 29 girls, median age: 5 years) who were treated with VCR chemotherapy (a total of 136 cases, including both induction and reinduction phases) from January 2012 to December 2013 in our hospital...
2015: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Noriko Nakamura, Amy L Inselman, Gene A White, Ching-Wei Chang, Raul A Trbojevich, Estatira Sephr, Kristie L Voris, Ralph E Patton, Matthew S Bryant, Wafa Harrouk, Barry S McIntyre, Paul M D Foster, Deborah K Hansen
BACKGROUND: 2-Hydroxy-4-methoxybenzophenone (HMB) is an ultraviolet (UV) absorbing compound used in many cosmetic products as a UV-protecting agent and in plastics for preventing UV-induced photodecomposition. HMB has been detected in over 95% of randomly collected human urine samples from adults and from premature infants, and it may have estrogenic potential. METHODS: To determine the effects of maternal and lactational exposure to HMB on development and reproductive organs of offspring, time-mated female Harlan Sprague-Dawley rats were dosed with 0, 1000, 3000, 10,000, 25,000, or 50,000 ppm HMB (seven to eight per group) added to chow from gestation day 6 until weaning on postnatal day (PND) 23...
February 2015: Birth Defects Research. Part B, Developmental and Reproductive Toxicology
R N Lerch, N R Kitchen, C Baffaut, E D Vories
We document the 20-yr-long research effort to study the transport of N and P to surface and groundwater in Goodwater Creek Experimental Watershed. We also document related efforts in nearby claypan watersheds and watersheds with contrasting soil and hydrologic conditions across the northern Missouri-southern Iowa region. Details of the analytical methods, instrumentation, method detection limits, and quality assurance program used to generate the data are described along with a brief overview of significant findings...
January 2015: Journal of Environmental Quality
E John Sadler, Kenneth A Sudduth, Scott T Drummond, Earl D Vories, Patrick E Guinan
Knowledge of weather, particularly precipitation, is fundamental to interpreting watershed and hydrologic processes. The long-term weather record in the Goodwater Creek Experimental Watershed (GCEW) complements hydrologic and water quality data in the region. The GCEW also is the core of the Central Mississippi River Basin (CMRB) node of the Long-Term Agroecosystem Research network. Our objectives are to (i) describe the climatological context of the GCEW and CMRB settings, (ii) document instrumentation and the data collection, quality assurance, and reduction processes; (iii) provide examples of the data obtained and descriptive statistics; and (iv) document the availability of and access methods to obtain the data from the web-based data access portal at ...
January 2015: Journal of Environmental Quality
E John Sadler, Robert N Lerch, Newell R Kitchen, Stephen H Anderson, Claire Baffaut, Kenneth A Sudduth, Anthony A Prato, Robert J Kremer, Earl D Vories, D Brent Myers, Robert Broz, Randall J Miles, Fred J Young
Many challenges currently facing agriculture require long-term data on landscape-scale hydrologic responses to weather, such as from the Goodwater Creek Experimental Watershed (GCEW), located in northeastern Missouri, USA. This watershed is prone to surface runoff despite shallow slopes, as a result of a significant smectitic clay layer 30 to 50 cm deep that restricts downward flow of water and gives rise to a periodic perched water table. This paper is the first in a series that documents the database developed from GCEW...
January 2015: Journal of Environmental Quality
Nguyen Van Cao, Nguyen Thien Tao, Amelia Moore, Alfred Montoya, Arne Redsted Rasmussen, Kenneth Broad, Harold K Voris, Zoltan Takacs
Conservation of sea snakes is virtually nonexistent in Asia, and its role in human-snake interactions in terms of catch, trade, and snakebites as an occupational hazard is mostly unexplored. We collected data on sea snake landings from the Gulf of Thailand, a hotspot for sea snake harvest by squid fishers operating out of the ports of Song Doc and Khanh Hoi, Ca Mau Province, Vietnam. The data were collected during documentation of the steps of the trading process and through interviewers with participants in the trade...
December 2014: Conservation Biology: the Journal of the Society for Conservation Biology
G A Eschenauer, E J Kwak, A Humar, B A Potoski, L G Clarke, R K Shields, R Abdel-Massih, F P Silveira, P Vergidis, C J Clancy, M H Nguyen
Guidelines recommend targeted antifungal prophylaxis for liver transplant (LT) recipients based on tiers of risk, rather than universal prophylaxis. The feasibility and efficacy of tiered, targeted prophylaxis is not well established. We performed a retrospective study of LT recipients who received targeted prophylaxis (n = 145; voriconazole [VORI; 54%], fluconazole [8%], no antifungal [38%]) versus universal VORI prophylaxis (n = 237). Median durations of targeted and universal prophylaxis were 11 and 6 days, respectively (p < 0...
January 2015: American Journal of Transplantation
Maren E Mason, Nathan D Voris, Hunter A Ortis, Amy A Geeding, Ray M Kaplan
OBJECTIVE: To compare larvicidal regimens of fenbendazole and moxidectin for reduction and suppression of cyathostomin fecal egg counts (FEC) in a transient herd of embryo transfer-recipient mares. DESIGN: Randomized, complete block, clinical trial. ANIMALS: 120 mares from 21 states, residing on 1 farm. PROCEDURES: An initial fecal sample was collected from each mare; mares with an FEC ≥ 200 eggs/g were assigned to treatment groups...
October 15, 2014: Journal of the American Veterinary Medical Association
Tenley Voris, Robert Quinn, Mohammed Elahi, Hashim Alani
An unusual case of a patient who presented with a subcutaneous soft tissue lesion of the back is described. The patient had no preceding history of cutaneous malignancy or local trauma. Excision of the lesion revealed a diagnosis consistent with basal cell carcinoma with deep infiltration. The site was re-excised with a generous margin to ensure complete removal. There has been no recurrence for 18 months. This case is presented to underscore the rarity and importance of its existence.
2003: Canadian Journal of Plastic Surgery, Journal Canadien de Chirurgie Plastique
Yvon F Bryan, Andrew Voris, Joseph May
No abstract text is available yet for this article.
2013: International Anesthesiology Clinics
Edwin R Cadet, Andrew K Chan, George C Vorys, Thomas Gardner, Bob Yin
BACKGROUND: Debate exists on whether hip labral tears should be surgically repaired, partially resected, or reconstructed. Furthermore, limited data exist regarding the fluid seal properties of hip labrum repair and/or reconstruction with iliotibial band autograft when compared with the labrum-intact condition. Hypothesis/ PURPOSE: The purpose of this study was to investigate the fluid seal properties of hip labral repair and reconstruction techniques. We hypothesized that hip labral repair preserves the acetabular labral fluid seal greater than labral tear, partial-resection, and reconstruction conditions...
October 2012: American Journal of Sports Medicine
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