Andrea Kovacs, Roksana Karim, Wendy J Mack, Jiaao Xu, Zhi Chen, Eva Operskalski, Toni Frederick, Alan Landay, John Voris, La Shonda Spencer, Mary A Young, Phyllis C Tien, Michael Augenbraun, Howard D Strickler, Lena Al-Harthi
BACKGROUND: Because activation of T cells is associated with human immunodeficiency virus (HIV) pathogenesis, CD4 and CD8 activation levels in patients coinfected with HIV and hepatitis C virus (HCV) may explain conflicting reports regarding effects of HCV on HIV disease progression. METHODS: Kaplan-Meier and multivariate Cox regression models were used to study the risk of incident clinical AIDS and AIDS-related deaths among 813 HCV-negative women with HIV infection, 87 HCV-positive nonviremic women with HIV coinfection, and 407 HCV-positive viremic women with HIV coinfection (median follow-up time, 5...
March 15, 2010: Journal of Infectious Diseases