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biosimilar glp

Lavakumar Reddy Aramadhaka, Alyson Prorock, Bojan Dragulev, Yongde Bao, Jay W Fox
Like most natural product libraries animal venoms have long been recognized as potentially rich source of biologically active molecules with the potential to be mined for the discovery of drugs, drug leads and/or biosimilars. In this work we demonstrate as a proof of concept a novel approach to explore venoms for potential biosimilarity to other drugs based on their ability to alter the transcriptomes of test cell lines followed by informatic searches and Connectivity Mapping to match the action of the venom on the cell gene expression to that of other drugs in the Connectivity Map (C-Map) database...
July 2013: Toxicon: Official Journal of the International Society on Toxinology
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