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Clonal keratosis

Nam Kyung Roh, Hyung Jin Hahn, Yang Won Lee, Yong Beom Choe, Kyu Joong Ahn
BACKGROUND: Seborrheic keratosis (SK) is one of the most common epidermal tumors of the skin. However, only a few large-scale clinicohistopathological investigations have been conducted on SK or on the possible correlation between histopathological SK subtype and location. OBJECTIVE: The aim of this study was to analyze the clinical and histopathological features of a relatively large number of cases of diagnosed SK. METHODS: Two hundred and seventy-one pathology slides of skin tissue from patients with clinically diagnosed SK and 206 cases of biopsy-proven SK were analyzed...
April 2016: Annals of Dermatology
Lorenzo Squillace, Milena Cappello, Caterina Longo, Elvira Moscarella, Roberto Alfano, Giuseppe Argenziano
BACKGROUND: Seborrheic keratoses (SKs) may sometimes mimic benign and malignant skin tumors, and a biopsy can be necessary in order to rule out malignancy. METHODS: From the database of our pigmented lesion clinic, we evaluated the dermoscopic features of difficult-to-diagnose SKs that were biopsied between January 2010 and December 2014. RESULTS: SKs represented 3.8% of all excised lesions (161/ 4,182). Specifically, 91 (56.5%) were excised to rule out melanoma, 63 (39...
2016: Dermatology: International Journal for Clinical and Investigative Dermatology
F Persechino, C Longo, A M Cesinaro, E Cinotti, S Ciardo, G Pellacani, S Bassoli
No abstract text is available yet for this article.
February 2016: Annales de Dermatologie et de Vénéréologie
Shiro Niiyama, Toshiaki Oharaseki, Hideki Mukai
Hidroacanthoma simplex is a benign tumor of the skin, macroscopically resembling seborrheic keratosis or Bowen's disease and histologically mimicking clonal-type seborrheic keratosis. We observed a plaque of 70 × 50 mm on the right flank part. From clinical appearance, we suspected Bowen's disease; however, based on immunohistochemical findings, we made a diagnosis of hidroacanthoma simplex.
September 2015: Case Reports in Dermatology
Noriyuki Misago, Takuya Inoue, Shuji Toda
We herein report a patient who clinically presented with a yellowish, flat plaque that histopathologically showed a benign lesion mainly composed of intraepidermal basaloid nests with sebaceous differentiation. This lesion was considered to be fundamentally apocrine poroma (hidroacanthoma simplex type) with sebaceous differentiation. Nests composed of typical poroid cells were seen, and the results of immunostaining for lumican supported this diagnosis and excluded the possibility of clonal seborrheic keratosis...
February 2016: Journal of Cutaneous Pathology
Sheena Ramyead, Salvador J Diaz-Cano, Lucia Pozo-Garcia
No abstract text is available yet for this article.
August 2015: Journal of the American Academy of Dermatology
Mirjana Popadić
No abstract text is available yet for this article.
May 2015: Journal of the American Academy of Dermatology
M Majores, E Bierhoff
Actinic (solar) keratosis is an intraepidermal squamous neoplasm of sun-damaged skin and by far the most frequent neoplastic skin lesion. A subdivison into three grades has been proposed with increasing acceptance not least because of the therapeutic consequences. The transition to invasive squamous cell carcinoma is reported in 5-10 % and with immunosuppression in 30 % of patients.Bowen's disease is a variant of squamous cell carcinoma in situ of the skin and the mucocutaneous junction. The differentiation from bowenoid papulosis as a lesion associated with human papillomavirus (HPV), actinic (solar) keratosis grade III, intraepidermal poroid lesions and in cases of clonal type from clonal seborrhoic keratosis and Paget's disease is very important...
February 2015: Der Pathologe
Yota Sato, Taku Fujimura, Erika Tamabuchi, Takahiro Haga, Setsuya Aiba
Hidroacanthoma simplex (HAS), also known as intraepidermal eccrine poroma, is a rare eccrine adnexal tumor that tends to be misdiagnosed as other types of benign skin tumor, including clonal seborrheic keratosis. Notably, HAS is sometimes misdiagnosed and treated by cryosurgery as seborrheic keratosis, which could trigger the later development of porocarcinoma. Therefore, accurate diagnosis of HAS is indispensable for dermatologists to avoid the development of malignant tumors by an unsuitable treatment. In this report, we present the characteristic dermoscopy findings of HAS...
May 2014: Case Reports in Dermatology
Jason C Reutter, Kim R Geisinger, Jennifer Laudadio
OBJECTIVE: We sought to determine the prevalence of human papillomavirus (HPV) subtypes in vulvar seborrheic keratoses (SK) by polymerase chain reaction (PCR) in women with a theoretically low risk of recent HPV transmission. We also attempted to identify which histopathologic features best correlated with HPV and specific subtypes. METHODS: Twenty-eight cases of vulvar SK in women older than 50 years old were retrospectively pulled from our files from a 7-year period...
April 2014: Journal of Lower Genital Tract Disease
C Longo, I Zalaudek, E Moscarella, A Lallas, S Piana, G Pellacani, G Argenziano
BACKGROUND: The diagnosis of clonal seborrheic keratosis may be challenging clinically and histologically. OBJECTIVE: In our study, we describe the common aspects of this benign entity that show peculiar dermoscopic and confocal findings. METHODS: A total of nine clonal seborrheic keratosis were analyzed. RESULTS: Upon dermoscopy, it reveals the presence of globular-like structures and sharply demarcated borders whereas confocal microscopy displays the typical intraepidermal nesting of pigmented keratinocytes that permits to have a reliable in vivo diagnosis...
October 2014: Journal of the European Academy of Dermatology and Venereology: JEADV
Sarah E Yagerman, Ashfaq A Marghoob
No abstract text is available yet for this article.
August 2013: Journal of the American Academy of Dermatology
Nobuko Yoshimi, Yasutomo Imai, Ayako Kakuno, Airo Tsubura, Kiyofumi Yamanishi, Ichiro Kurokawa
OBJECTIVES: Seborrheic keratosis (SK) is classified into six types: hyperkeratotic; acanthotic; irritated; clonal; reticulated; and adenoid. However, the origins of the respective types of SK remain unclear. METHODS: To clarify the histogenetic origins of SK, we performed immunohistochemical studies of keratin (K) and filaggrin expression, taking into account the histopathological classifications of SK. RESULTS: Hyperkeratotic SK mainly expressed K1, K10, and filaggrin...
June 2014: International Journal of Dermatology
Ryoko Takayama, Shin-Ichi Ansai, Toshiyuki Ishiwata, Tetsushi Yamamoto, Yoko Matsuda, Zenya Naito, Seiji Kawana
Lumican, a member of the small leucine-rich proteoglycan family, regulates the assembly and diameter of collagen fibers in the extracellular matrix of various tissues. The lumican expression correlates with pathological conditions and the growth and metastasis of various malignancies. In cutaneous neoplasms, the lumican expression is lower in advanced-stage malignant melanomas that invade the dermis than in early-stage melanomas. Furthermore, we have recently reported that the expression pattern of lumican is different from that of actinic keratosis and the Bowen disease...
August 2014: American Journal of Dermatopathology
Alan S Boyd, Lloyd E King
The intraepidermal epithelioma (of Borst-Jadasson) constitutes a much discussed and debated entity. Currently, this diagnosis is rarely made in part, as ascribing clinical features to such lesions has, to date, proven difficult. In addition, intraepidermal proliferation of atypical cells with clonal features is more likely diagnosed as squamous cell carcinomas in situ, porocarcinomas or inflamed seborrheic keratoses. However, cutaneous tumors exhibiting microscopic and immunohistochemical features of clonally profligate malignant basaloid cells solely of epidermal origin do rarely exist...
April 2013: Pathology, Research and Practice
Olga Simionescu, Bogdan Ovidiu Popescu, Mariana Costache, Emilia Manole, Stefan Spulber, Mihaela Gherghiceanu, Andreas Blum
The aetiology of seborrheic keratoses (SK), the most common benign epithelial tumours, and any relationship with malignancy are not yet known. As a protective anti-cancer mechanism, apoptosis reflects cellular loss as a reaction to proliferative activity. The objective of this study was to quantify apoptosis in different SK types (acanthotic, hyperkeratotic, reticulated, irritated and clonal) and correlate the dermoscopic picture with apoptosis rate. After a qualitative and quantitative analysis of dermoscopic images, we defined a new quantitative dermoscopic score (C3V2F, crypts, millia cysts, colours, hairpin vessels, irregular vessels, fissures) from 0 to 22, which enabled us to establish cut-offs correlating with apoptosis rates...
June 2012: Journal of Cellular and Molecular Medicine
Almut Böer-Auer, Meriem Jones, Olesya V Lyasnichaya
BACKGROUND: The histopathologic pattern of clonal seborrheic keratosis (SK) is quite similar to the nested pattern of pagetoid Bowen's disease [squamous cell carcinoma in situ (SCCIS)], and differentiation between the two can be challenging, especially when only small pieces are available for interpretation. METHODS: Eleven examples of clonal SK and 13 examples of pagetoid SCCIS were examined histopathologically (tabulating necrotic keratinocytes, suprabasal mitoses, infiltrate, parakeratosis housing plump nuclei, crowding of nuclei) and immunohistochemically (using Ki-67, bcl-2, cytokeratin 7 and cytokeratin 10)...
February 2012: Journal of Cutaneous Pathology
Viviana Lora, Brigitte Chouvet, Jean Kanitakis
The true nature of the so-called intraepidermal epithelioma of Borst-Jadassohn is poorly understood; whether this represents a distinct tumor or a morphological phenomenon [Borst-Jadassohn phenomenon (BJP)] shared by different entities has been debated. So far, no detailed immunohistochemical studies have been performed to address this issue. The aim of our study was to get further insight into the pathogenesis of the intraepidermal epithelioma of Borst-Jadassohn/BJP. Tumors showing the BJP [mainly clonal seborrheic keratoses (cSK) and clonal Bowen disease (cBD)] were studied and compared with typical (nonclonal) counterparts...
July 2011: American Journal of Dermatopathology
Christian Hafner, Agustí Toll, Alejandro Fernández-Casado, Julie Earl, Miriam Marqués, Francesco Acquadro, Marinela Méndez-Pertuz, Miguel Urioste, Núria Malats, Julie E Burns, Margaret A Knowles, Juan C Cigudosa, Arndt Hartmann, Thomas Vogt, Michael Landthaler, Ramón M Pujol, Francisco X Real
Malignant tumors result from the accumulation of genetic alterations in oncogenes and tumor suppressor genes. Much less is known about the genetic changes in benign tumors. Seborrheic keratoses (SK) are very frequent benign human epidermal tumors without malignant potential. We performed a comprehensive mutational screen of genes in the FGFR3-RAS-MAPK and phosphoinositide 3-kinase (PI3K)-AKT pathways from 175 SK, including multiple lesions from each patient. SK commonly harbored multiple bona fide oncogenic mutations in FGFR3, PIK3CA, KRAS, HRAS, EGFR, and AKT1 oncogenes but not in tumor suppressor genes TSC1 and PTEN...
November 30, 2010: Proceedings of the National Academy of Sciences of the United States of America
Neira Puizina-Ivić, Damir Sapunar, Dujomir Marasović, Lina Mirić
The Bcl-2 protein has been shown to suppress cell death and protects cell against apoptosis induced by different death-inducing signals. In this study the authors have analyzed imunohistochemically the expression of Bcl-2 protein in the histopathological variants of the most common malignant tumors of the skin--basal cell carcinoma (BCC) and squamous cell tumor (SCC), as well as in the precancerous lesion actinic keratosis (AK) and in benign tumor seborrheic keratosis (SK). Bcl-2 expression in solid, adenoid and cystic variants of BCC exhibited immunoreactivity of tumor stroma with more intense staining among peripheral palisading cells...
October 2008: Collegium Antropologicum
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