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Plexiform neurilemmoma

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https://www.readbyqxmd.com/read/25980170/-1-case-of-vocal-cord-plexiform-schwannoma
#1
Qunfeng Yao
Summary A 36 years old patient with hoarseness for 2 years and got worsen for one month, electronic laryngoscopy showed a red smooth-faced wide based neoplasm on the posterior 2/3 of the right side of the vocal cords. The neoplasm was excised under suspension laryngoscope . The pathologic results showed:Cells were weave patterned, infiltrative growth, mitotic figure was rare. Immunohistochemical results showed CD34 (-), SMA (-), DM (-), S - 100 (+). The pathological diagnosis was plexiform schwannoma.
December 2014: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/25551830/soluble-axl-a-possible-circulating-biomarker-for-neurofibromatosis-type-1-related-tumor-burden
#2
Gunnar Johansson, Po-Chun Peng, Po-Yuan Huang, Hsiung-Fei Chien, Kuo-Tai Hua, Min-Liang Kuo, Chin-Tin Chen, Ming-Jen Lee
Neurofibromatosis type 1 (NF1) is the most common tumor predisposition disorder affecting 1/3500 worldwide. Patients are at risk of developing benign (neurofibromas) and malignant peripheral nerve sheath tumors (MPNST). The AXL receptor tyrosine kinase has been implicated in several kinds of cancers, but so far no studies have investigated the role of AXL in NF1 related tumorigenesis. Recently, the soluble fraction from the extracellular domain of AXL (sAXL) has been found in human plasma, and its level was correlated to poor prognosis in patients with renal cancer...
2014: PloS One
https://www.readbyqxmd.com/read/25306531/multiple-plexiform-schwannomas-in-the-plantar-aspect-of-the-foot-case-report-and-literature-review
#3
REVIEW
Xiao-na Li, Jian-ling Cui, Seemon Petrus Christopasak, Abhinav Kumar, Zhi-gang Peng
BACKGROUND: Plexiform schwannoma (PS) is a rare, peripheral nerve sheath tumor arranged in a plexiform pattern. CASE PRESENTATION: We report an unusual case of a 19-year-old woman, who complained of pain in the plantar aspect of the left foot. Magnetic resonance image (MRI) demonstrates three solitary nodules of varying sizes in the deep soft tissue of the plantar aspect of the foot that are homogeneously isointense to skeletal muscle on T1-weighted images and hyperintense on T2-weighted fat-suppressed images, especially the rim of the lesion...
2014: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/25109740/tagln-expression-is-upregulated-in-nf1-associated-malignant-peripheral-nerve-sheath-tumors-by-hypomethylation-in-its-promoter-and-subpromoter-regions
#4
Gun-Hoo Park, Su-Jin Lee, Hyunee Yim, Jae-Ho Han, Hyon J Kim, Young-Bae Sohn, Jung Min Ko, Seon-Yong Jeong
Neurofibromatosis type 1 (NF1) caused by NF1 gene mutation is a commonly inherited autosomal dominant disorder. Malignant peripheral nerve sheath tumors (MPNSTs), a type of aggressive sarcoma, are a major cause of mortality in NF1 patients. The malignant transformation of benign plexiform neurofibromas (PNs) to MPNSTs is a marked peculiarity in NF1 patients, yet the pathogenesis remains poorly understood. We found that an actin-associated protein transgelin (SM22) was highly expressed in NF1-deficient MPNST tissues compared to NF1-deficient PN tissues using immunohistological staining and primary cultured MPNST cells in western blot analysis...
October 2014: Oncology Reports
https://www.readbyqxmd.com/read/24717998/a-hybrid-schwannoma-of-median-nerve
#5
Erkam Komurcu, Burak Kaymaz, Gurhan Adam, Ferhat Gokmen, Asli Murath
Schwannomas are the most common benign neoplasms of the peripheral nerves in the upper extremity originating from the schwann cells of nerve sheath. They account for 5% of all tumours in upper extremity. Schwannomas are usually solitary, encapsulated and homogeneous masses and present with slowly growing masses, sometimes associated with pain and paresthesia. Pre-operative evaluation is based on ultrasonography and magnetic resonance imaging, but final diagnosis requires histopathology. It is important to distinguish plexiform schwannoma from plexiform neurofibroma because of the possibility of malignant transformation in plexiform neurofibroma...
March 2014: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/24681606/co-targeting-the-mapk-and-pi3k-akt-mtor-pathways-in-two-genetically-engineered-mouse-models-of-schwann-cell-tumors-reduces-tumor-grade-and-multiplicity
#6
Adrienne L Watson, Leah K Anderson, Andrew D Greeley, Vincent W Keng, Eric P Rahrmann, Amanda L Halfond, Natasha M Powell, Margaret H Collins, Tilat Rizvi, Christopher L Moertel, Nancy Ratner, David A Largaespada
Malignant peripheral nerve sheath tumors (MPNSTs) are soft tissue sarcomas that occur spontaneously, or from benign plexiform neurofibromas, in the context of the genetic disorder Neurofibromatosis Type 1 (NF1). The current standard treatment includes surgical resection, high-dose chemotherapy, and/or radiation. To date, most targeted therapies have failed to demonstrate effectiveness against plexiform neurofibromas and MPNSTs. Recently, several studies suggested that the mTOR and MAPK pathways are involved in the formation and progression of MPNSTs...
March 30, 2014: Oncotarget
https://www.readbyqxmd.com/read/24556484/case-presentations-and-review-of-plexiform-schwannoma-in-the-foot
#7
REVIEW
Samirah A Mohammed, Martin M Pressman, Brian Schmidt, Nina Babu
Plexiform schwannoma is a soft tissue tumor that rarely presents in the lower extremity. We have reported on 2 cases of plexiform schwannomas that occurred in the foot and ankle. Owing to the relative obscurity of this condition in the lower extremity, we have also provided an overview of plexiform schwannomas and discussed the differences between this and other suspicious nodular soft tissue masses. The first patient was a 38-year-old female, who had a soft tissue mass located on the lateral aspect of her right foot that became symptomatic...
March 2014: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/24455054/ancient-schwannoma-of-the-hard-palate-an-uncommon-case-report-and-review
#8
Maria L Gainza-Cirauqui, Asier Eguía-Del Valle, Rafael Martínez-Conde, Juan C Coca-Meneses, José M Aguirre-Urizar
Schwannoma or neurilemmoma is an infrequent benign tumor in the oral cavity that originates from the Schwann cells on the neural sheath of the peripheral nerves. Schwannomas are frequently located in the soft tissues of head and neck region, but only a 1 to 12% of them are located in the oral cavity. Some histological variants of schwannoma have been described including the cellular, plexiform, epithelioid, ancient, and melanocytic types. The "ancient schwannoma" is an uncommon variant of this tumor that shows specific histological characteristics, and is rare in the oral cavity with less than 15 cases described on the literature...
February 1, 2013: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/24165375/multinodular-plexiform-schwannoma-of-the-ulnar-nerve
#9
Chiao Yee Lim, Tze Hau Low, Ruban Sivanoli, Kok Kheng Teh, Ravindran Thuraisingham
No abstract text is available yet for this article.
January 2014: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/23947092/plexiform-schwannoma-of-the-clitoris-in-a-young-girl-a-case-report
#10
Abdul Ghani Nur Azurah, Sonia Grover, Duncan McGregor
BACKGROUND: Schwannoma (neurilemoma) is a benign, slow-growing tumor of the nerve sheath. These tumors are rarely found in the female genitalia and to date only 1 case of clitoral schwannoma has been reported in a young girl. We report here the second case of schwannoma of the clitoris. CASE: A 6-year-old girl presented with an enlarging clitoris. An alteration in her clitoral appearance had first been noted at 2 years of age. However, the size had further increased in the year prior to presentation...
July 2013: Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/23363231/plexiform-schwannoma-of-the-rectum
#11
REVIEW
Shinya Kawaguchi, Rei Yamamoto, Mitsuhiro Yamamura, Jun Oyamada, Hyoe Sato, Hirofumi Fuke, Tadashi Yabana
Plexiform schwannoma is a benign peripheral nerve sheath tumor composed exclusively of Schwann cells arranged in a plexiform pattern. Most plexiform schwannomas are skin tumors and visceral localization is very rare. To our knowledge, there are six cases localized in visceral organs. We describe herein the first known case of plexiform schwannoma of the rectum resected by endoscopic submucosal dissection (ESD). A 77-year-old woman presented with a short history of anal pain. Sigmoidoscopy demonstrated a submucosal tumor, 20 mm in diameter, of the rectum below the peritoneal reflection (Rb)...
January 2014: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/23270209/plexiform-multinodular-schwannoma-of-soft-palate-report-of-a-case
#12
Stylianos Kapetanakis, Ioannis Vasileiadis, Aristotelis Petousis, Aliki Fiska, Anna Stavrianaki
Plexiform schwannoma is a rare benign neoplasm of the neural sheath characterized by a multinodular plexiform growth pattern. Only 5% of schwannomas have a plexiform or multinodular growth pattern. Schwannoma apparently derives from the Schwann cells. Extracranially, 25% of all schwannomas are located in the head and neck region, but only 1% show an intraoral origin. The intraoral lesions show a predilection for the tongue, followed by the palate, buccal mucosa, lip and gingival. Microscopic examination is necessary to confirm the diagnosis...
July 2012: Folia Medica
https://www.readbyqxmd.com/read/22976661/plexiform-hypoglossal-schwannoma-of-the-tongue-and-the-submandibular-region
#13
Akmam H Al-Mahdi, Luay E Al-Khurrhi, Ghada Z Atto, Ameer Dhaher
Hypoglossal schwannomas usually develop in the intracranial portion of the brain. Incidence of hypoglossal schwannomas of the submandibular region is extremely rare. A 27-year-old patient presented to us with hypoglossal schwannoma of the tongue and the submandibular region. The tumor was excised intraorally combined with submandibular approach. Histopathologic examination revealed a plexiform schwannoma (a rare variant).
September 2012: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/22965512/plexiform-schwannoma-of-the-duodenum-accompanying-pyloric-stenosis-report-of-a-case
#14
Ali Aktekın, Selvinaz Özkara, Kaan Merıç, Meryem Günay Gürleyık, Fügen Aker, Abdullah Sağlam
Plexiform schwannoma is a benign peripheral nerve sheath tumor and is composed of Schwann cells arranged in a plexiform pattern. Most plexiform schwannomas are skin tumors, and there has been no case report of this tumor originating in the duodenum. We describe the first known case of plexiform schwannoma of the duodenum. A 60-year-old man presented with a short history of food intolerance, epigastric discomfort, fullness and bloatedness, sometimes vomiting, and weight loss, without any clinical picture of neurofibromatosis...
August 2012: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/22937797/recurrent-orbital-schwannomas-clinical-course-and-histopathologic-correlation
#15
Michelle Kron, Brenda L Bohnsack, Steven M Archer, Jonathan B McHugh, Alon Kahana
BACKGROUND: Schwannomas are slow-growing typically encapsulated tumors composed of differentiated Schwann cells, the primary class of peripheral glial cells. Complete excision is the treatment of choice for orbital schwannomas that cause pain, disfigurement, diplopia, or optic neuropathy. The presence of multiple schwannomas in a single patient suggests possible association with neurofibromatosis type 2 (NF2) or schwannomatosis. CASE PRESENTATION: We present 2 patients who experienced recurrent orbital schwannoma without evidence for neurofibromatosis...
2012: BMC Ophthalmology
https://www.readbyqxmd.com/read/22847037/unusual-intramaxillary-plexiform-schwannoma
#16
Pravin N Lambade, Dipti Lambade, Tapan K Saha, R S Dolas, Akshay Dhobley
BACKGROUND: Neoplasms of peripheral nerve in the head and neck region are of common occurrence, but origin in the oral and para-oral tissues is uncommon and they rarely occur centrally within the jaws. Schwannoma is a benign neoplasm originating from the neural sheath of peripheral soft tissues, but its occurrence within the jaw bones is most unusual. Plexiform schwannoma is a unique variant of Schwann cell tumours having plexiform pattern. Literature revealed only one case of plexiform schwannoma of the jaw bones, i...
June 2013: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/22714859/plexiform-schwannoma-of-the-nasal-tip-surgical-approach
#17
Renata Caroline Mendonça Ferraz, Juliana Antoniolli Duarte, Reginaldo Raimundo Fujita, Shirlei Shizue Nagata Pignatari
No abstract text is available yet for this article.
June 2012: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/22551922/technical-aspects-of-the-anterior-transmanubrial-approach-in-thoracic-inlet-tumor-surgery
#18
REVIEW
Antonio Francisco Honguero Martínez, Carlos A Rombolá, Pablo León Atance
Surgical treatment of thoracic inlet tumors represents a challenge to the surgeon due to its location and anatomical elements contained in that region. Several surgical approaches have been proposed, each of them showing some advantages but drawbacks as well. In our opinion, the anterior transmanubrial approach described in 1997 is one of the most convenient. The objective of this paper is to describe and comment on some technical aspects of the procedure in order to aid surgeons who intend to perform this surgical approach...
November 2012: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/22416678/plexiform-melanocytic-schwannoma-a-mimic-of-melanoma
#19
Iwei Yeh, Zsolt Argenyi, Swapna S Vemula, Paul S Furmanczyk, Danielle Bouffard, Timothy H McCalmont
We present a unique dermal tumor for which we propose the term plexiform melanocytic schwanomma. The proliferation consisted of lobules of epithelioid and spindled cells with S100, Melan-A and HMB-45 positivity but without obvious melanin pigmentation. The nuclei were moderately pleomorphic in some areas, and in a few areas the mitotic index was elevated. Schwannian differentiation was inferred from the presence of areas with nuclear palisading resembling Verocay bodies, from plexiform architecture and from the presence of a thin rim of EMA positivity around the tumor...
May 2012: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/22327363/pathology-of-peripheral-nerve-sheath-tumors-diagnostic-overview-and-update-on-selected-diagnostic-problems
#20
REVIEW
Fausto J Rodriguez, Andrew L Folpe, Caterina Giannini, Arie Perry
Peripheral nerve sheath tumors are common neoplasms, with classic identifiable features, but on occasion, they are diagnostically challenging. Although well-defined subtypes of peripheral nerve sheath tumors were described early in the history of surgical pathology, controversies regarding the classification and grading of these tumors persist. Advances in molecular biology have provided new insights into the nature of the various peripheral nerve sheath tumors, and have begun to suggest novel targeted therapeutic approaches...
March 2012: Acta Neuropathologica
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