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https://www.readbyqxmd.com/read/29746338/oncological-and-survival-outcomes-in-watch-and-wait-patients-with-a-clinical-complete-response-after-neoadjuvant-chemoradiotherapy-for-rectal-cancer-a-systematic-review-and-pooled-analysis
#1
Mit Dattani, Richard J Heald, Ghaleb Goussous, Jack Broadhurst, Guilherme P São Julião, Angelita Habr-Gama, Rodrigo Oliva Perez, Brendan J Moran
OBJECTIVE: The aim of this study was to evaluate the oncological and survival outcomes of a Watch and Wait policy in rectal cancer after a clinical complete response (cCR) following neoadjuvant chemoradiotherapy. BACKGROUND: The detection of a cCR after neoadjuvant treatment may facilitate a nonoperative approach in selected patients. However, the long-term safety of this strategy remains to be validated. METHOD: This is a systematic review of the literature to determine the oncological outcomes in Watch and Wait patients...
May 9, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29603906/antibacterial-activity-and-in-vivo-wound-healing-potential-of-phenolic-extracts-from-jaboticaba-skin
#2
Gustavo Henrique Andrade Machado, Tamara Rezende Marques, Thaís Cristina Lima de Carvalho, André Carvalho Duarte, Flávia Cíntia de Oliveira, Michelle Carlota Gonçalves, Roberta Hilsdorf Piccoli, Angelita Duarte Corrêa
In this study, different phenolic extracts were obtained from the jaboticaba skin meal (JSM), whose phenolic compounds were characterized and their antibacterial activities were assessed. Moreover, the activity of lyophilized ethanolic extract of jaboticaba skin (EEJS) on wound healing was analyzed in rats. The JSM phenolic extracts were obtained in four ways: aqueous, methanolic, ethanolic, and acetone extracts. The phenolic compounds were characterized in these extracts by high performance liquid chromatography and their antibacterial activities were evaluated...
March 30, 2018: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29600246/evolution-of-sangiovese-wines-with-varied-tannin-and-anthocyanin-ratios-during-oxidative-aging
#3
Angelita Gambuti, Luigi Picariello, Alessandra Rinaldi, Luigi Moio
Changes in phenolic compounds, chromatic characteristics, acetaldehyde, and protein-reactive tannins associated with oxidative aging were studied in Sangiovese wines with varied tannin T/anthocyanin A ratios. For this purpose, three Sangiovese vineyards located in Tuscany were considered in the 2016 vintage. To obtain wines with different T/A ratios, two red wines were produced from each vinification batch: a free run juice with a lower T/A ratio and a marc pressed wine with a higher T/A ratio. An overall of six wines with T/A ratios ranging between 5 and 23 were produced...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29549783/the-psychological-social-and-behavioural-impact-of-a-parent-s-cancer-on-adolescent-and-young-adult-offspring-aged-10-24-at-time-of-diagnosis-a-systematic-review
#4
REVIEW
Julia Morris, Deborah Turnbull, David Preen, Ian Zajac, Angelita Martini
This study reviewed the literature regarding the psychological, social, and behavioural impact of parental cancer on offspring aged 10-24 years, at the time of the parent's first diagnosis. A systematic literature review was conducted following 2015 PRISMA guidelines. Seven studies met inclusion criteria. Offspring were impacted by their parent's cancer and experienced psychological and behavioural problems. Daughters and offspring who experienced more problems at their parent's diagnosis appeared to be most impacted...
June 2018: Journal of Adolescence
https://www.readbyqxmd.com/read/29512230/non-pharmacological-interventions-during-childbirth-for-pain-relief-anxiety-and-neuroendocrine-stress-parameters-a-randomized-controlled-trial
#5
Angelita José Henrique, Maria Cristina Gabrielloni, Patricia Rodney, Márcia Barbieri
AIM: This study aimed to investigate the effect of warm shower hydrotherapy and perineal exercises with a ball on pain, anxiety, and neuroendocrine stress parameters during childbirth. METHODS: This randomized controlled trial was conducted with 128 women during childbirth, admitted for hospital birth in São Paulo, Brazil, from June 2013 to February 2014. The participants were randomly assigned into one of the following intervention groups: received warm shower hydrotherapy (GA); performed perineal exercises with a ball (GB); and combined intervention group, which received warm shower hydrotherapy and perineal exercises with a ball (GC) (n = 39)...
March 7, 2018: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/29464046/identification-and-characterization-of-novel-enhanced-cell-penetrating-peptides-for-anti-cancer-cargo-delivery
#6
Xiguang Zhang, Jean Yves Brossas, Christophe Parizot, Jean Marc Zini, Angelita Rebollo
Cell penetrating peptides (CPP) are able cross the membrane and to transport cargos, presenting a great potential in drug delivery and diagnosis. In this paper, we have identified novel natural or synthetic CPPs. We have validated their rapid and efficient time and dose-dependent penetration, the absence of toxicity, the intracellular localization and the stability to proteases degradation, one of the main bottlenecks of peptides. Moreover, we have associate a cargo (an interfering peptide blocking the association of the serine/threonine phosphatase PP2A to its inhibitor, the oncogene SET) to the new generated shuttles and showed that they new bi-functional peptides keep the original properties of the shuttle and, in addition, are able to induce apoptosis due to the properties of the cargo...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29420434/quality-of-life-in-patients-with-rectal-cancer-after-chemoradiation-watch-and-wait-policy-versus-standard-resection-are-we-comparing-apples-to-oranges
#7
COMMENT
Bruna Borba Vailati, Angelita Habr-Gama, Adrian E Mattacheo, Guilherme Pagin São Julião, Rodrigo Oliva Perez
No abstract text is available yet for this article.
March 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29413272/contact-radiation-therapy-for-achieving-organ-preservation-in-rectal-cancer-after-standard-neoadjuvant-chemoradiation-looking-for-a-place-in-the-sun
#8
EDITORIAL
Angelita Habr-Gama, Rodrigo O Perez
No abstract text is available yet for this article.
March 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29412280/palliative-therapy-in-adults-with-cancer-a-cross-sectional-study
#9
Angelita Visentin, Maria de Fátima Mantovani, Luciana Puchalski Kalinke, Shirley Boller, Leila Maria Mansano Sarquis
OBJECTIVE: To characterize the socioeconomic and clinical profile of adult cancer patients in palliative therapy. METHOD: Cross-sectional study in an oncology hospital in Paraná, with 124 adult patients who started palliative therapy in the period from Jan. 2 to June 30, 2015. RESULTS: Of the participating population, 60.5% were women, 68.5% white, 48.4% married, 72.6% catholic and with income of one to two minimum wages. Non-smokers, 45...
March 2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29395519/identification-of-suitable-adjuvant-for-vaccine-formulation-with-the-neospora-caninum-antigen-ncsrs2
#10
Amanda Fernandes Pinheiro, Bárbara Couto Roloff, Angelita da Silveira Moreira, Maria Elisabeth Aires Berne, Renato Andreotti Silva, Fábio Pereira Leivas Leite
The parasite Neospora caninum is the main cause of abortion in cattle in many countries around the world, so a vaccine is a rational approach method for the control of the disease. An effective vaccine should be able to prevent both, the horizontal and vertical transmission of N. caninum. In this study, the immune vaccinal response of the recombinant protein rNcSRS2 of N. caninum expressed in Pichia pastoris and formulated with water-in-oil emulsion, xanthan gum, and alum hydroxide was assessed in an experimental murine model...
February 21, 2018: Vaccine
https://www.readbyqxmd.com/read/29386885/peptides-derived-from-plasmodium-falciparum-leucine-rich-repeat-1-bind-to-serine-threonine-phosphatase-type-1-and-inhibit-parasite-growth-in-vitro
#11
Christine Pierrot, Xiguang Zhang, Gigliola Zanghi, Aline Fréville, Angelita Rebollo, Jamal Khalife
No abstract text is available yet for this article.
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29242038/nmr-based-phytochemical-analysis-of-vitis-vinifera-cv-falanghina-leaves-characterization-of-a-previously-undescribed-biflavonoid-with-antiproliferative-activity
#12
Luciana Tartaglione, Angelita Gambuti, Paola De Cicco, Giuseppe Ercolano, Angela Ianaro, Orazio Taglialatela-Scafati, Luigi Moio, Martino Forino
Vitis vinifera cv Falanghina is an ancient grape variety of Southern Italy. A thorough phytochemical analysis of the Falanghina leaves was conducted to investigate its specialised metabolite content. Along with already known molecules, such as caftaric acid, quercetin-3-O-β-d-glucopyranoside, quercetin-3-O-β-d-glucuronide, kaempferol-3-O-β-d-glucopyranoside and kaempferol-3-O-β-d-glucuronide, a previously undescribed biflavonoid was identified. For this last compound, a moderate bioactivity against metastatic melanoma cells proliferation was discovered...
March 2018: Fitoterapia
https://www.readbyqxmd.com/read/29228375/influence-of-temperature-on-in-vitro-zoosporogenesis-of-pythium-insidiosum
#13
Cristina Gomes Zambrano, Angelita Reis Gomes, Carolina Litchina Brasil, Júlia de Souza Silveira Valente, Carolina Quintana Braga, Maria Isabel de Azevedo, Sônia de Avila Botton, Daniela Isabel Brayer Pereira
This study verified the influence of different temperatures on P. insidiosum in vitro zoosporogenesis. P. insidiosum isolates (n = 26) were submitted to zoosporogenesis and incubated at 5°C, 15°C, 20°C and 37°C (1st stage). Grass fragments were evaluated under optical microscopy at 4, 8, and 24 hours of incubation. Afterward, all isolates were incubated at 37°C and assessed at the same periods of time (2nd stage). The development of hyphae, presence of vesicles, zoosporangia and zoospores were checked...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29219915/not-taking-no-for-an-answer
#14
Angelita Habr-Gama
No abstract text is available yet for this article.
January 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29217398/is-neoadjuvant-chemoradiation-with-dose-escalation-and-consolidation-chemotherapy-sufficient-to-increase-surgery-free-and-distant-metastases-free-survival-in-baseline-ct3-rectal-cancer
#15
Guilherme Pagin São Julião, Angelita Habr-Gama, Bruna Borba Vailati, Patricia Bailão Aguilar, Jorge Sabbaga, Sérgio Eduardo Alonso Araújo, Adrian Mattacheo, Flavia Andrea Alexandre, Laura Melina Fernandez, Diogo Bugano Gomes, Joaquim Gama-Rodrigues, Rodrigo Oliva Perez
Patients with cT3 rectal cancer are less likely to develop complete response to neoadjuvant chemoradiation (nCRT) and still face significant risk for systemic relapse. In this setting, radiation (RT) dose-escalation and consolidation chemotherapy in "extended" nCRT regimens have been suggested to improve primary tumor response and decrease the risks of systemic recurrences. For these reasons we compared surgery-free and distant-metastases free survival among cT3 patients undergoing standard or extended nCRT...
January 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29184475/management-of-the-complete-clinical-response
#16
REVIEW
Angelita Habr-Gama, Guilherme Pagin São Julião, Bruna Borba Vailati, Ivana Castro, Debora Raffaele
Organ preservation is considered in the management of selected patients with rectal cancer. Complete clinical response observed after neoadjuvant chemoradiation for rectal cancer is one of these cases. Patients who present complete clinical response are candidates to the watch-and-wait approach, when radical surgery is not immediately performed and is offered only to patients in the event of a local relapse. These patients are included in a strict follow-up, and up of 70% of them will never be operated during the follow-up...
November 2017: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29109582/pharmacy-in-brazil-progress-and-challenges-on-the-road-to-expanding-clinical-practice
#17
Angelita Cristine Melo, Dayani Galato, Hellen Karoline Maniero, Josélia Cintya Quintão Pena Frade, Tarcisio José Palhano, Wellington Barros da Silva, Walter da Silva Jorge João
No abstract text is available yet for this article.
September 2017: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/29107485/the-cryo-em-structure-of-a-novel-40s-kinetoplastid-specific-ribosomal-protein
#18
Jailson Brito Querido, Eder Mancera-Martínez, Quentin Vicens, Anthony Bochler, Johana Chicher, Angelita Simonetti, Yaser Hashem
Kinetoplastids are potentially lethal protozoan pathogens affecting more than 20 million people worldwide. There is a critical need for more specific targets for the development of safer anti-kinetoplastid therapeutic molecules that can replace the scarce and highly cytotoxic current drugs. The kinetoplastid ribosome represents a potential therapeutic target due to its relative structural divergence when compared with its human counterpart. However, several kinetoplastid-specific ribosomal features remain uncharacterized...
December 5, 2017: Structure
https://www.readbyqxmd.com/read/29097277/interfering-peptides-targeting-protein-protein-interactions-the-next-generation-of-drugs
#19
REVIEW
Heriberto Bruzzoni-Giovanelli, Valerie Alezra, Nicolas Wolff, Chang-Zhi Dong, Pierre Tuffery, Angelita Rebollo
Protein-protein interactions (PPIs) are well recognized as promising therapeutic targets. Consequently, interfering peptides (IPs) - natural or synthetic peptides capable of interfering with PPIs - are receiving increasing attention. Given their physicochemical characteristics, IPs seem better suited than small molecules to interfere with the large surfaces implicated in PPIs. Progress on peptide administration, stability, biodelivery and safety are also encouraging the interest in peptide drug development...
February 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29067428/effect-of-therapeutic-hypothermia-initiated-after-6-hours-of-age-on-death-or-disability-among-newborns-with-hypoxic-ischemic-encephalopathy-a-randomized-clinical-trial
#20
RANDOMIZED CONTROLLED TRIAL
Abbot R Laptook, Seetha Shankaran, Jon E Tyson, Breda Munoz, Edward F Bell, Ronald N Goldberg, Nehal A Parikh, Namasivayam Ambalavanan, Claudia Pedroza, Athina Pappas, Abhik Das, Aasma S Chaudhary, Richard A Ehrenkranz, Angelita M Hensman, Krisa P Van Meurs, Lina F Chalak, Amir M Khan, Shannon E G Hamrick, Gregory M Sokol, Michele C Walsh, Brenda B Poindexter, Roger G Faix, Kristi L Watterberg, Ivan D Frantz, Ronnie Guillet, Uday Devaskar, William E Truog, Valerie Y Chock, Myra H Wyckoff, Elisabeth C McGowan, David P Carlton, Heidi M Harmon, Jane E Brumbaugh, C Michael Cotten, Pablo J Sánchez, Anna Maria Hibbs, Rosemary D Higgins
Importance: Hypothermia initiated at less than 6 hours after birth reduces death or disability for infants with hypoxic-ischemic encephalopathy at 36 weeks' or later gestation. To our knowledge, hypothermia trials have not been performed in infants presenting after 6 hours. Objective: To estimate the probability that hypothermia initiated at 6 to 24 hours after birth reduces the risk of death or disability at 18 months among infants with hypoxic-ischemic encephalopathy...
October 24, 2017: JAMA: the Journal of the American Medical Association
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