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https://www.readbyqxmd.com/read/29109582/pharmacy-in-brazil-progress-and-challenges-on-the-road-to-expanding-clinical-practice
#1
Angelita Cristine Melo, Dayani Galato, Hellen Karoline Maniero, Josélia Cintya Quintão Pena Frade, Tarcisio José Palhano, Wellington Barros da Silva, Walter da Silva Jorge João
No abstract text is available yet for this article.
September 2017: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/29107485/the-cryo-em-structure-of-a-novel-40s-kinetoplastid-specific-ribosomal-protein
#2
Jailson Brito Querido, Eder Mancera-Martínez, Quentin Vicens, Anthony Bochler, Johana Chicher, Angelita Simonetti, Yaser Hashem
Kinetoplastids are potentially lethal protozoan pathogens affecting more than 20 million people worldwide. There is a critical need for more specific targets for the development of safer anti-kinetoplastid therapeutic molecules that can replace the scarce and highly cytotoxic current drugs. The kinetoplastid ribosome represents a potential therapeutic target due to its relative structural divergence when compared with its human counterpart. However, several kinetoplastid-specific ribosomal features remain uncharacterized...
October 13, 2017: Structure
https://www.readbyqxmd.com/read/29097277/interfering-peptides-targeting-protein-protein-interactions-the-next-generation-of-drugs
#3
REVIEW
Heriberto Bruzzoni-Giovanelli, Valerie Alezra, Nicolas Wolff, Chang-Zhi Dong, Pierre Tuffery, Angelita Rebollo
Protein-protein interactions (PPIs) are well recognized as promising therapeutic targets. Consequently, interfering peptides (IPs) - natural or synthetic peptides capable of interfering with PPIs - are receiving increasing attention. Given their physicochemical characteristics, IPs seem better suited than small molecules to interfere with the large surfaces implicated in PPIs. Progress on peptide administration, stability, biodelivery and safety are also encouraging the interest in peptide drug development...
October 31, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/29067428/effect-of-therapeutic-hypothermia-initiated-after-6-hours-of-age-on-death-or-disability-among-newborns-with-hypoxic-ischemic-encephalopathy-a-randomized-clinical-trial
#4
RANDOMIZED CONTROLLED TRIAL
Abbot R Laptook, Seetha Shankaran, Jon E Tyson, Breda Munoz, Edward F Bell, Ronald N Goldberg, Nehal A Parikh, Namasivayam Ambalavanan, Claudia Pedroza, Athina Pappas, Abhik Das, Aasma S Chaudhary, Richard A Ehrenkranz, Angelita M Hensman, Krisa P Van Meurs, Lina F Chalak, Shannon E G Hamrick, Gregory M Sokol, Michele C Walsh, Brenda B Poindexter, Roger G Faix, Kristi L Watterberg, Ivan D Frantz, Ronnie Guillet, Uday Devaskar, William E Truog, Valerie Y Chock, Myra H Wyckoff, Elisabeth C McGowan, David P Carlton, Heidi M Harmon, Jane E Brumbaugh, C Michael Cotten, Pablo J Sánchez, Anna Maria Hibbs, Rosemary D Higgins
Importance: Hypothermia initiated at less than 6 hours after birth reduces death or disability for infants with hypoxic-ischemic encephalopathy at 36 weeks' or later gestation. To our knowledge, hypothermia trials have not been performed in infants presenting after 6 hours. Objective: To estimate the probability that hypothermia initiated at 6 to 24 hours after birth reduces the risk of death or disability at 18 months among infants with hypoxic-ischemic encephalopathy...
October 24, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29062856/synthesis-and-chemometrics-of-thymol-and-carvacrol-derivatives-as-larvicides-against-aedes-aegypti
#5
Viviane Barros Silva, Daniele Lima Travassos, Angelita Nepel, Andersson Barison, Emmanoel Vilaça Costa, Luciana Scotti, Marcus Tulius Scotti, Francisco Jaime Bezerra Mendonça-Junior, Roseli La Corte Dos Santos, Sócrates Cabral de Holanda Cavalcanti
BACKGROUND: Thymol and carvacrol have previously demonstrated larvicidal activity against Aedes aegypti (Diptera: Culicidae). In view of this fact, it was of our interest to obtain synthetic derivatives and evaluate their larvicidal activity on Ae. aegypti larvae. METHODS: Structural modifications were performed on thymol and carvacrol in an effort to understand the functional groups necessary for modulating their activities and to lead possibly to more effective larvae control agents...
June 2017: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/29032297/postoperative-complications-following-primary-penile-inversion-vaginoplasty-among-330-male-to-female-transgender-patients
#6
Thomas W Gaither, Mohannad A Awad, E Charles Osterberg, Gregory P Murphy, Angelita Romero, Marci L Bowers, Benjamin N Breyer
PURPOSE: Studies of surgical complications of penile inversion vaginoplasty are limited due to small sample sizes. We describe postoperative complications after penile inversion vaginoplasty and evaluated age, body mass index and years on hormone replacement therapy as risk factors for complications. MATERIALS AND METHODS: We retrospectively reviewed the records of male to female patients who presented for primary penile inversion vaginoplasty to a high volume surgeon (MLB) from 2011 to 2015...
October 12, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28982710/identification-of-extremely-premature-infants-at-low-risk-for-early-onset-sepsis
#7
MULTICENTER STUDY
Karen M Puopolo, Sagori Mukhopadhyay, Nellie I Hansen, C Michael Cotten, Barbara J Stoll, Pablo J Sanchez, Edward F Bell, Abhik Das, Angelita M Hensman, Krisa P Van Meurs, Myra H Wyckoff
BACKGROUND: Premature infants are at high risk of early-onset sepsis (EOS) relative to term infants, and most are administered empirical antibiotics after birth. We aimed to determine if factors evident at birth could be used to identify premature infants at lower risk of EOS. METHODS: Study infants were born at 22 to 28 weeks' gestation in Neonatal Research Network centers from 2006 to 2014. EOS was defined by isolation of pathogenic species from blood or cerebrospinal fluid culture at ≤72 hours age...
November 2017: Pediatrics
https://www.readbyqxmd.com/read/28957005/systemic-histomoniasis-in-a-leucistic-indian-peafowl-pavo-cristatus-from-southern-brazil
#8
Mariana de Mello Zanim Michelazzo, João Pedro Sasse, Marielen de Souza, Victor Hugo Brunaldi Marutani, Ana Angelita Sampaio Baptista, João Luis Garcia, Amauri Alcindo Alfieri, Selwyn Arlington Headley
The pathological and molecular findings associated with Histomonas meleagridis are described in a leucistic Indian peafowl (Pavo cristatus) from Southern Brazil. The most significant gross findings were multifocal necrotizing hepatitis and diphtheric typhlitis. Histopathologic evaluation of the liver, ceca, kidney, spleen, and small intestine revealed systemic histomoniasis (SH) associated with intralesional and intravascular accumulations of histomonad organisms consistent with H. meleagridis. PCR was used to amplify the DNA of H...
September 2017: Avian Diseases
https://www.readbyqxmd.com/read/28816770/prevalence-of-disability-in-patients-with-musculoskeletal-pain-and-rheumatic-diseases-in-a-population-from-cuenca-ecuador
#9
Sergio Vicente Guevara-Pacheco, Astrid Feican-Alvarado, Jorge Delgado-Pauta, Angelita Lliguisaca-Segarra, Ingris Pelaez-Ballestas
OBJECTIVE: The aim of this study was to determine the prevalence of disability in patients with musculoskeletal pain and rheumatic diseases in Cuenca, Ecuador. METHODS: We performed a cross-sectional analytical study with randomized sampling in 4877 subjects, from urban and rural areas. COPCORD (Community Oriented Program for Control of Rheumatic Diseases)-validated questionnaire was administered house-to-house to identify subjects with nontraumatic musculoskeletal pain and rheumatic diseases...
September 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28801081/effects-of-therapeutic-touch-on-healing-of-the-skin-in-rats
#10
André Luiz Thomaz de Souza, David Patrick Carvalho Rosa, Bruno Anjos Blanco, Patrícia Passaglia, Angelita Maria Stabile
CONTEXT: Therapeutic touch is a complementary treatment directed toward the balance of the energy field surrounding living beings. OBJECTIVE: This study's aim was to investigate the effect of therapeutic touch on wound area contraction and fibroblast proliferation in rat skin. DESIGN: This study was conducted using 24 male Wistar rats with dorsal wounds of diameter 8mm. The rats were divided into the following two groups: a control group: in this, the wounds were sanitized with filtered water and neutral-pH soap and a treatment group: in this, the wounds were sanitized as in the control group but the rats also underwent to daily sessions of therapeutic touch...
July 1, 2017: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/28791283/increasing-incidence-of-colorectal-cancer-in-adolescents-and-young-adults-aged-15-39-years-in-western-australia-1982-2007-examination-of-colonoscopy-history
#11
Lakkhina Troeung, Nita Sodhi-Berry, Angelita Martini, Eva Malacova, Hooi Ee, Peter O'Leary, Iris Lansdorp-Vogelaar, David B Preen
AIMS: To examine trends in colorectal cancer (CRC) incidence and colonoscopy history in adolescents and young adults (AYAs) aged 15-39 years in Western Australia (WA) from 1982 to 2007. DESIGN: Descriptive cohort study using population-based linked hospital and cancer registry data. METHOD: Five-year age-standardized and age-specific incidence rates of CRC were calculated for all AYAs and by sex. Temporal trends in CRC incidence were investigated using Joinpoint regression analysis...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28754333/effect-of-allopurinol-and-uric-acid-normalization-on-serum-lipids-hyperuricemic-subjects-a-systematic-review-with-meta-analysis
#12
REVIEW
Verônica Moreira Ferreira de Castro, Angelita Cristine de Melo, Vinícius Silva Belo, Valéria Ernestânia Chaves
Although uric acid is not part of any definition of metabolic syndrome, a number of studies have shown strong associations between the concentration of uric acid and metabolic syndrome or its components. The purpose of this systematic review with meta-analysis was to evaluate, using prospective interventional studies, the effects of allopurinol therapy and uric acid normalization on serum concentrations of triacylglycerol, total-cholesterol, LDL-cholesterol and HDL-cholesterol in hyperuricemic subjects. A systematic search of the PubMed and Scopus databases was performed following the guidelines described in the PRISMA statement...
July 25, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28742703/organ-preservation-in-ct2n0-rectal-cancer-after-neoadjuvant-chemoradiation-therapy-the-impact-of-radiation-therapy-dose-escalation-and-consolidation-chemotherapy
#13
Angelita Habr-Gama, Guilherme Pagin São Julião, Bruna Borba Vailati, Jorge Sabbaga, Patricia Bailão Aguilar, Laura Melina Fernandez, Sergio Eduardo Alonso Araújo, Rodrigo Oliva Perez
OBJECTIVE: To demonstrate the difference in organ-preservation rates and avoidance of definitive surgery among cT2N0 rectal cancer patients undergoing 2 different chemoradiation (CRT) regimens. BACKGROUND: Patients with cT2N0 rectal cancer are more likely to develop complete response to neoadjuvant CRT. Organ preservation has been considered an alternative treatment strategy for selected patients. Radiation dose-escalation and consolidation chemotherapy have been associated with increased rates of response and may improve chances of organ preservation among these patients...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28719026/in-vitro-antiproliferative-and-antibacterial-activities-of-essential-oils-from-four-species-of-guatteria
#14
Anderson R Santos, Thalita Gilda S Benghi, Angelita Nepel, Francisco A Marques, Adriana Q Lobão, Marta Cristina T Duarte, Ana Lúcia T G Ruiz, João E Carvalho, Beatriz H L N S Maia
The essential oils (EOs) extracted from four species of the genus Guatteria, G. australis, G. ferruginea, G. latifolia, and G. sellowiana were analyzed. A total of 24, 22, 25, and 19 constituents of the oils from four species, respectively, were identified by GC/MS. These oils showed qualitative and quantitative differences. All the oils contained the oxygenated sesquiterpenes spathulenol (11.04 - 40.29%) and caryophyllene oxide (7.74 - 40.13%) as predominant constituents. Evaluation of antiproliferative activity of the EOs showed strong selectivity (1...
July 18, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28704519/e2f1-somatic-mutation-within-mirna-target-site-impairs-gene-regulation-in-colorectal-cancer
#15
Camila M Lopes-Ramos, Bruna P Barros, Fernanda C Koyama, Paola A Carpinetti, Julia Pezuk, Nayara T S Doimo, Angelita Habr-Gama, Rodrigo O Perez, Raphael B Parmigiani
BACKGROUND: Genetic studies have largely concentrated on the impact of somatic mutations found in coding regions, and have neglected mutations outside of these. However, 3' untranslated regions (3' UTR) mutations can also disrupt or create miRNA target sites, and trigger oncogene activation or tumor suppressor inactivation. METHODS: We used next-generation sequencing to widely screen for genetic alterations within predicted miRNA target sites of oncogenes associated with colorectal cancer, and evaluated the functional impact of a new somatic mutation...
2017: PloS One
https://www.readbyqxmd.com/read/28704411/complete-factorial-design-to-adjust-ph-and-sugar-concentrations-in-the-inoculum-phase-of-ralstonia-solanacearum-to-optimize-p-3hb-production
#16
Karine Laste Macagnan, Mariane Igansi Alves, Amanda Ávila Rodrigues, Lígia Furlan, Rosane da Silva Rodrigues, Patrícia Diaz de Oliveira, Claire Tondo Vendruscolo, Angelita da Silveira Moreira
Poly(3-hydroxybutyrate) (P(3HB)) is a biodegradable plastic biopolymer that accumulates as lipophilic inclusions in the cytoplasm of some microorganisms. The biotechnological process by which P(3HB) is synthesized occurs in two phases. The first phase involves cell growth in a complex culture medium, while the second phase involves polymer accumulation in the presence of excess carbon sources. As such, the efficiency of the second phase depends on the first phase. The aim of this study was to evaluate culture media with different concentrations of sucrose and glucose and different pH values in the inoculum phase of Ralstonia solanacearum RS with the intention of identifying methods by which the biomass yield could be increased, subsequently enhancing the yield of P(3HB)...
2017: PloS One
https://www.readbyqxmd.com/read/28678960/aqueous-extract-of-psidium-guajava-leaves-phenolic-compounds-and-inhibitory-potential-on-digestive-enzymes
#17
Anderson A Simão, Tamara R Marques, Silvana Marcussi, Angelita D Corrêa
Leaves of Psidium guajava L. (guava) have been widely used in the popular way for prevention and treatment of various diseases. Thus, the objective of this study was to evaluate the inhibitory potential of leaves aqueous extract from three cultivars of P. guajava (Pedro Sato, Paluma and Século XXI) on α-amylase, α-glycosidase, lipase, and trypsin enzymes, in the presence or not of simulated gastric fluid and to determine the content of phenolic compounds by high performance liquid chromatography. All cultivars presented the same composition in phenolic compounds, but in different proportions...
June 29, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28645916/structures-and-dynamics-of-hibernating-ribosomes-from-staphylococcus-aureus-mediated-by-intermolecular-interactions-of-hpf
#18
Iskander Khusainov, Quentin Vicens, Rustam Ayupov, Konstantin Usachev, Alexander Myasnikov, Angelita Simonetti, Shamil Validov, Bruno Kieffer, Gulnara Yusupova, Marat Yusupov, Yaser Hashem
In bacteria, ribosomal hibernation shuts down translation as a response to stress, through reversible binding of stress-induced proteins to ribosomes. This process typically involves the formation of 100S ribosome dimers. Here, we present the structures of hibernating ribosomes from human pathogen Staphylococcus aureus containing a long variant of the hibernation-promoting factor (SaHPF) that we solved using cryo-electron microscopy. Our reconstructions reveal that the N-terminal domain (NTD) of SaHPF binds to the 30S subunit as observed for shorter variants of HPF in other species...
July 14, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28630569/leadership-preferences-of-adolescent-players-in-sport-influence-of-coach-gender
#19
Angelita B Cruz, Hyun-Duck Kim
The authors investigated the coaching behavior preferences and the relationships of these preferences with variables such as gender, type of sport, playing experience, competitive level, and coach gender among young athletes in the national badminton league. Participants were 167 elementary and high school badminton players (91 girls and 76 boys; age range = 9-18 years; M = 13.5 (SD = 2.22) years) competing in the badminton event of a national league. Players' preferences for coaching behavior were measured using athlete preference version of the LSS to evaluate the five dimensions of leadership behavior in a sporting context...
June 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28623651/an-investigation-of-support-services-available-by-internet-searching-to-families-impacted-by-a-parent-s-cancer
#20
Julia Nellie Morris, Jeneva Ohan, Angelita Martini
OBJECTIVE: Throughout a parent's cancer diagnosis and treatment, families are likely to turn to the Internet to find social, emotional and informational support services. It is important professionals understand the content and availability of support discoverable through web searches. This study identified and described web-based information regarding support services offered to families when a parent has cancer. METHODS: Pre-defined key search terms were searched across two public web browsers for a period of 3 months...
June 16, 2017: Psycho-oncology
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