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Tomáš Paus, Angelita Pui-Yee Wong, Catriona Syme, Zdenka Pausova
This Mini-Review describes sex differences in 66 quantitative characteristics of the brain and body measured in a community-based sample of 1,024 adolescents 12-18 years of age, members of the Saguenay Youth Study. Using an extensive phenotyping protocol, we have obtained measures in a number of domains, including brain structure, cognition, mental health, substance use, body composition, metabolism, cardiovascular reactivity, and life style. For each measure, we provide estimates of effect size (Cohen's d) and sex-specific correlations with age (Pearson R)...
January 2, 2017: Journal of Neuroscience Research
Manfred P Lutz, John R Zalcberg, Rob Glynne-Jones, Theo Ruers, Michel Ducreux, Dirk Arnold, Daniela Aust, Gina Brown, Krzysztof Bujko, Christopher Cunningham, Serge Evrard, Gunnar Folprecht, Jean-Pierre Gerard, Angelita Habr-Gama, Karin Haustermans, Torbjörn Holm, Koert F Kuhlmann, Florian Lordick, Gilles Mentha, Markus Moehler, Iris D Nagtegaal, Alessio Pigazzi, Salvatore Pucciarelli, Arnaud Roth, Harm Rutten, Hans-Joachim Schmoll, Halfdan Sorbye, Eric Van Cutsem, Jürgen Weitz, Florian Otto
No abstract text is available yet for this article.
October 4, 2016: European Journal of Cancer
Angelita Roma P Hebreo, Monalisa L Dungca
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
Angelita Roma P Hebreo, Cynthia D Ang-Munoz, Joycie Eulah H Abiera, Monalisa L Dungca, Betty D Mancao
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
Jemma Bhoday, Fraser Smith, Muhammed R Siddiqui, Svetlana Balyasnikova, Robert I Swift, Rodrigo Perez, Angelita Habr-Gama, Gina Brown
BACKGROUND: Pathological complete response after chemoradiotherapy for rectal cancer occurs in 10% to 30% of patients. The best method to identify such patients remains unclear. Clinical assessment of residual mucosal abnormality is considered the most accurate method. In our institution, magnetic resonance tumor regression grade is performed as routine to assess response. OBJECTIVE: The purpose of this study was to compare the sensitivity of magnetic tumor regression grade against residual mucosal abnormality in detecting patients with a pathological complete response...
October 2016: Diseases of the Colon and Rectum
Franck Martin, Jean-François Ménétret, Angelita Simonetti, Alexander G Myasnikov, Quentin Vicens, Lydia Prongidi-Fix, S Kundhavai Natchiar, Bruno P Klaholz, Gilbert Eriani
Eukaryotic mRNAs often contain a Kozak sequence that helps tether the ribosome to the AUG start codon. The mRNA of histone H4 (h4) does not undergo classical ribosome scanning but has evolved a specific tethering mechanism. The cryo-EM structure of the rabbit ribosome complex with mouse h4 shows that the mRNA forms a folded, repressive structure at the mRNA entry site on the 40S subunit next to the tip of helix 16 of 18S ribosomal RNA (rRNA). Toe-printing and mutational assays reveal that an interaction exists between a purine-rich sequence in h4 mRNA and a complementary UUUC sequence of helix h16...
August 24, 2016: Nature Communications
Bruna S da Silva, Diego L Rovaris, Jaqueline B Schuch, Nina R Mota, Renata B Cupertino, Angelita P Aroche, Guilherme P Bertuzzi, Rafael G Karam, Eduardo S Vitola, Luciana Tovo-Rodrigues, Eugenio H Grevet, Claiton H D Bau
BACKGROUND: The corticotropin-releasing hormone receptor 1 (CRHR1) gene has been repeatedly implicated in Major Depressive Disorder (MDD) in humans and animal models; however, the findings are not absolutely convergent. Since recent evidence from genome-wide association studies suggests that narrowing the phenotypic heterogeneity may be crucial in genetic studies of MDD, the aim of this study was to evaluate the effects of CRHR1 polymorphisms on MDD while addressing the influence of sex and smoking status...
November 15, 2016: Journal of Affective Disorders
Rodrigo O Perez, Angelita Habr-Gama, Guilherme P São Julião, Bruna B Vailati, Laura M Fernandez, Joaquim Gama-Rodrigues, Anamaria A Camargo
No abstract text is available yet for this article.
September 2016: Diseases of the Colon and Rectum
Dalton A Dos Anjos, Rodrigo O Perez, Angelita Habr-Gama, Guilherme P São Julião, Bruna B Vailati, Laura M Fernandez, João B de Sousa, Carlos A Buchpiguel
BACKGROUND: Previous studies using PET/CT imaging have failed to accurately identify complete responders to neoadjuvant chemoradiation among patients with rectal cancer. The use of metabolic parameters alone or imprecise delineation of baseline and residual tumor volumes may have contributed for these disappointing findings. OBJECTIVE: The purpose of this study was to determine the accuracy of complete response identification in rectal cancer after neoadjuvant chemoradiation by sequential PET/CT imaging with a decrease in tumor metabolism and volume using optimal tumor volume delineation...
September 2016: Diseases of the Colon and Rectum
Fabiana Bettoni, Cibele Masotti, Angelita Habr-Gama, Bruna R Correa, Joaquim Gama-Rodrigues, Maria R Vianna, Bruna B Vailati, Guilherme P São Julião, Laura M Fernandez, Pedro A Galante, Anamaria A Camargo, Rodrigo O Perez
OBJECTIVE: Demonstrate intratumoral genetic heterogeneity in rectal cancer. BACKGROUND: Several clinical management decisions in rectal cancer may be influenced by pretreatment biopsy information. However, in the setting of significant intratumoral heterogeneity, biopsies may not be representative of the entirety of the tumor and limit the reliability of the information provided from them for clinical decision management. METHODS: Three fragments from a single rectal adenocarcinoma were chosen for whole-exome sequencing followed by mutation detection analysis...
July 29, 2016: Annals of Surgery
Leociley R A Menezes, Cinara O D Sousa Costa, Ana Carolina B da C Rodrigues, Felipe R do E Santo, Angelita Nepel, Lívia M Dutra, Felipe M A Silva, Milena B P Soares, Andersson Barison, Emmanoel V Costa, Daniel P Bezerra
Xylopia laevigata (Annonaceae), known locally as "meiú" or "pindaíba", is widely used in folk medicine in Northeastern Brazil. In the present work, we performed phytochemical analyses of the stem of X. laevigata, which led to the isolation of 19 alkaloids: (-)-roemerine, (+)-anonaine, lanuginosine, (+)-glaucine, (+)-xylopine, oxoglaucine, (+)-norglaucine, asimilobine, (-)-xylopinine, (+)-norpurpureine, (+)-N-methyllaurotetanine, (+)-norpredicentrine, (+)-discretine, (+)-calycinine, (+)-laurotetanine, (+)-reticuline, (-)-corytenchine, (+)-discretamine and (+)-flavinantine...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Diego L Rovaris, Angelita P Aroche, Bruna S da Silva, Djenifer B Kappel, Júlio C Pezzi, Mateus L Levandowski, Adriana R B Hess, Jaqueline B Schuch, Rosa M M de Almeida, Rodrigo Grassi-Oliveira, Claiton H D Bau
Crack cocaine addicted inpatients that present more severe withdrawal symptoms also exhibit higher rates of depressive symptoms. There is strong evidence that the identification of genetic variants in depression is potentialized when reducing phenotypic heterogeneity by studying selected groups. Since depression has been associated to dysregulation of the hypothalamic-pituitary-adrenal axis, this study evaluated the effects of SNPs in stress-related genes on depressive symptoms of crack cocaine addicts at early abstinence and over the detoxification treatment (4th, 11th and 18th day post admission)...
September 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
Angelita Simonetti, Jailson Brito Querido, Alexander G Myasnikov, Eder Mancera-Martinez, Adeline Renaud, Lauriane Kuhn, Yaser Hashem
mRNA translation initiation in eukaryotes requires the cooperation of a dozen eukaryotic initiation factors (eIFs) forming several complexes, which leads to mRNA attachment to the small ribosomal 40S subunit, mRNA scanning for start codon, and accommodation of initiator tRNA at the 40S P site. eIF3, composed of 13 subunits, 8 core (a, c, e, f, h, l, k, and m) and 5 peripheral (b, d, g, i, and j), plays a central role during this process. Here we report a cryo-electron microscopy structure of a mammalian 48S initiation complex at 5...
July 21, 2016: Molecular Cell
Clizia Capuani, Marcello Melone, Angelita Tottene, Luca Bragina, Giovanna Crivellaro, Mirko Santello, Giorgio Casari, Fiorenzo Conti, Daniela Pietrobon
Migraine is a common disabling brain disorder. A subtype of migraine with aura (familial hemiplegic migraine type 2: FHM2) is caused by loss-of-function mutations in α2 Na(+),K(+) ATPase (α2 NKA), an isoform almost exclusively expressed in astrocytes in adult brain. Cortical spreading depression (CSD), the phenomenon that underlies migraine aura and activates migraine headache mechanisms, is facilitated in heterozygous FHM2-knockin mice with reduced expression of α2 NKA The mechanisms underlying an increased susceptibility to CSD in FHM2 are unknown...
2016: EMBO Molecular Medicine
Jennifer Foster, Jodi DeLibertis, Angelita Nixon
No abstract text is available yet for this article.
July 2016: Journal of Midwifery & Women's Health
Hyung J Cho, Neil Desai, Angelita Florendo, Christine Marshall, Jaime Michalski, Nathan Lee, Andrew Dunn
Short stay admissions that are outside of observation unit models hold challenges for throughput and decreasing length of stay (LOS). In our institution at Mount Sinai Hospital in New York City, United States, we noticed a lack of communication about potential next-day discharges from the day and night admission teams to the inpatient teams. Our hospitalist division started the Early Discharge Initiation Project (E-DIP), a system of flagging and communicating potential discharges to improve this problem. We used a multidisciplinary approach with PDSA cycles, engaging members of all teams involved in this process, including the nocturnists...
2016: BMJ Quality Improvement Reports
Marian Valentini Pezzi, Eneida Rejane Rabelo-Silva, Angelita Paganin, Emiliane Nogueira de Souza
PURPOSE: Determine the outcomes and interventions for patients undergoing cardiac catheterization with nursing diagnosis of impaired tissue integrity. METHODS: Survey with e-questionnaires sent for expert nurses in two rounds. FINDINGS: Only one nursing outcome was approved: tissue integrity-skin and mucosa and five related interventions, namely, pressure control, topical drug administration, care of incision site, care of injuries, and infection control...
October 2016: International Journal of Nursing Knowledge
Lauren Tingey, Mary F Cwik, Summer Rosenstock, Novalene Goklish, Francene Larzelere-Hinton, Angelita Lee, Rosemarie Suttle, Melanie Alchesay, Kirk Massey, Allison Barlow
BACKGROUND: American Indian (AI) adolescents are disproportionately burdened by alcohol abuse and heavy binge use, often leading to problematic drinking in adulthood. However, many AI communities also have large proportions of adults who abstain from alcohol. OBJECTIVE: To understand these concurrent and divergent patterns, we explored the relationship between risk and protective factors for heavy binge alcohol use among a reservation-based sample of AI adolescents...
June 17, 2016: American Journal of Drug and Alcohol Abuse
Angelita Martini, Julia N Morris, David Preen
OBJECTIVE: This paper reviewed the relationship between non-clinical, client-oriented promotional campaigns to raise bowel cancer awareness and screening engagement. METHOD: An integrative literature review using predefined search terms was conducted to summarise the accumulated knowledge. Data was analysed by coding and categorising, then synthesized through development of themes. RESULTS: Eighteen of 116 studies met inclusion criteria. Promotional campaigns had varying impact on screening uptake for bowel cancer...
October 2016: Patient Education and Counseling
Anaelís C Campos, James Albiero, Alessandra B Ecker, Cristina M Kuroda, Lívia E F Meirelles, Angelita Polato, Maria C B Tognim, Márcia A Wingeter, Jorge J V Teixeira
BACKGROUND: First detected in the United States in 1996, Klebsiella pneumoniae carbapenemase (KPC) has spread internationally among gram-negative bacteria, especially K pneumoniae. These microorganisms can cause serious infections in hospitalized patients, and there are few therapeutic options, culminating in increased mortality. The objective of this study was to describe the occurrence of outbreaks that were caused by KPC-producing K pneumoniae, emphasizing the interventions that were implemented to contain the outbreaks...
May 5, 2016: American Journal of Infection Control
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