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https://www.readbyqxmd.com/read/28645916/structures-and-dynamics-of-hibernating-ribosomes-from-staphylococcus-aureus-mediated-by-intermolecular-interactions-of-hpf
#1
Iskander Khusainov, Quentin Vicens, Rustam Ayupov, Konstantin Usachev, Alexander Myasnikov, Angelita Simonetti, Shamil Validov, Bruno Kieffer, Gulnara Yusupova, Marat Yusupov, Yaser Hashem
In bacteria, ribosomal hibernation shuts down translation as a response to stress, through reversible binding of stress-induced proteins to ribosomes. This process typically involves the formation of 100S ribosome dimers. Here, we present the structures of hibernating ribosomes from human pathogen Staphylococcus aureus containing a long variant of the hibernation-promoting factor (SaHPF) that we solved using cryo-electron microscopy. Our reconstructions reveal that the N-terminal domain (NTD) of SaHPF binds to the 30S subunit as observed for shorter variants of HPF in other species...
June 23, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28630569/leadership-preferences-of-adolescent-players-in-sport-influence-of-coach-gender
#2
Angelita B Cruz, Hyun-Duck Kim
The authors investigated the coaching behavior preferences and the relationships of these preferences with variables such as gender, type of sport, playing experience, competitive level, and coach gender among young athletes in the national badminton league. Participants were 167 elementary and high school badminton players (91 girls and 76 boys; age range = 9-18 years; M = 13.5 (SD = 2.22) years) competing in the badminton event of a national league. Players' preferences for coaching behavior were measured using athlete preference version of the LSS to evaluate the five dimensions of leadership behavior in a sporting context...
June 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28623651/an-investigation-of-support-services-available-by-internet-searching-to-families-impacted-by-a-parent-s-cancer
#3
Ms Julia Morris, Jeneva Ohan, Angelita Martini
OBJECTIVE: Throughout a parent's cancer diagnosis and treatment, families are likely to turn to the Internet to find social, emotional and informational support services. It is important professionals understand the content and availability of support discoverable through web searches. This study identified and described web-based information regarding support services offered to families when a parent has cancer. METHODS: Pre-defined key search terms were searched across two public web browsers for a period of 3 months...
June 16, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28622703/qualitative-determination-of-human-chorionic-gonadotropin-in-vaginal-washings-for-the-early-diagnosis-of-premature-rupture-of-fetal-membranes
#4
Camila Buziquia Dartibale, Nelson Shozo Uchimura, Luiz Nery, Angelita Polato Schumeish, Liza Yurie Teruya Uchimura, Rosangela Getirana Santana, Taqueco Teruya Uchimura
Purpose This study aimed to evaluate and validate the qualitative human chorionic gonadotropin β subunit (β-hCG) test of the vaginal fluid washings of pregnant women with premature rupture of fetal membranes (PROM). Methods Cross-sectional study of pregnant women between gestational weeks 24 and 39 who underwent consultations in one of our institutions. They were divided into two groups: group A (pregnant women clinically diagnosed with PROM) and group B (pregnant women without loss of amniotic liquid)...
June 16, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28591069/world-gastroenterology-organisation-global-guidelines-gerd-global-perspective-on-gastroesophageal-reflux-disease
#5
Richard Hunt, David Armstrong, Peter Katelaris, Mary Afihene, Abate Bane, Shobna Bhatia, Min-Hu Chen, Myung Gyu Choi, Angelita Cristine Melo, Kwong Ming Fock, Alex Ford, Michio Hongo, Aamir Khan, Leonid Lazebnik, Greger Lindberg, Maribel Lizarzabal, Thein Myint, Joaquim Prado Moraes-Filho, Graciela Salis, Jaw Town Lin, Raj Vaidya, Abdelmounen Abdo, Anton LeMair
No abstract text is available yet for this article.
July 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28589643/residual-risk-of-transmission-of-human-immunodeficiency-virus-and-hepatitis-c-virus-infections-by-blood-transfusion-in-northern-brazil
#6
Priscilla Cristina Moura Vieira, Letícia Martins Lamarão, Carlos Eduardo de Melo Amaral, Angelita Silva de Miranda Corrêa, Maria Salete Maciel de Lima, Katarine Antônia Dos Santos Barile, Karine Lisboa Damasceno de Almeida, Vinicius de Albuquerque Sortica, André Salim Kayath, Rommel Mario Rodríguez Burbano
BACKGROUND: Nucleic acid test (NAT) blood screening for human immunodeficiency virus (HIV) and hepatitis C virus (HCV) was introduced in northern Brazil in July 2012. There are several Brazilian articles that have evaluated transfusion transmission risks for HIV and HCV. However, to our knowledge, this article is the first to evaluate the impact of HIV and HCV NAT implementation for blood screening in northern Brazil. The aim of this study was to determine the prevalence and incidence rates of HIV and HCV among blood donors and to compare the residual risk of transfusion transmission of these infections, before (2009-2011) and after (2012-2014) NAT implementation...
June 7, 2017: Transfusion
https://www.readbyqxmd.com/read/28582611/dynamic-dna-origami-device-for-measuring-compressive-depletion-forces
#7
Michael W Hudoba, Yi Luo, Angelita Zacharias, Michael G Poirier, Carlos E Castro
The ability to self-assemble nanodevices with programmed structural dynamics that can sense and respond to the local environment could enable transformative applications in fields including molecular robotics, nanomanufacturing, and nanomedicine. The responsive function of biomolecules is often driven by alterations in conformational distributions mediated by highly sensitive interactions with the local environment. Here, we mimic this approach by engineering inherent nanoscale structural dynamics (nanodynamics) into a DNA device that exhibits a distribution of conformations including two stable states separated by a transition state where the energy barrier height is on the scale of the thermal energy, kBT = 4...
June 9, 2017: ACS Nano
https://www.readbyqxmd.com/read/28555192/the-use-of-xanthan-gum-as-vaccine-adjuvant-an-evaluation-of-immunostimulatory-potential-in-balb-c-mice-and-cytotoxicity-in-vitro
#8
Rodrigo Andrade Schuch, Thaís Larré Oliveira, Thaís Farias Collares, Leonardo Garcia Monte, Guilherme Roig Inda, Odir Antonio Dellagostin, Claire Tondo Vendruscolo, Angelita da Silveira Moreira, Daiane Drawanz Hartwig
The successful production of new, safe, and effective vaccines that generate immunological memory is directly related to adjuvant feature, which is responsible for increasing and/or modulating the immune response. Several compounds display adjuvant activity, including carbohydrates. These compounds play important roles in the immune response, as well as having biocompatible properties in vaccine formulations. One such carbohydrate is xanthan gum, a polysaccharide that is produced by the plant-pathogenic bacterium Xanthomonas spp...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28501249/new-strategies-in-rectal-cancer
#9
REVIEW
Guilherme Pagin São Julião, Angelita Habr-Gama, Bruna Borba Vailati, Sergio Eduardo Alonso Araujo, Laura Melina Fernandez, Rodrigo Oliva Perez
In recent years, our understanding of rectal cancer has improved, including how locally advanced disease responds to chemotherapy and radiation. This has led to new innovations and advances in the treatment of rectal cancer, which includes organ-preserving strategies for responsive disease, and minimally invasive approaces for the performance of total mesorectal excision/protectomyh for persistently advanced disease. This article discusses new strategies for rectal cancer therapy, including Watch and Wait, local excision, minimally invasive proctectomy, and transanal total mesorectal excision particularly in the setting of preoperative multimodality treatment...
June 2017: Surgical Clinics of North America
https://www.readbyqxmd.com/read/28498001/abce1-a-special-factor-that-orchestrates-translation-at-the-crossroad-between-recycling-and-initiation
#10
Eder Mancera-Martínez, Jailson Brito Querido, Leos Shivaya Valasek, Angelita Simonetti, Yaser Hashem
For many years initiation and termination of mRNA translation have been studied separately. However, a direct link between these two isolated stages has been suggested by the fact that some initiation factors also control termination and can even promote ribosome recycling; i.e. the last stage where post-terminating 80 S ribosomes are split to start a new round of initiation. Notably, it is now firmly established that, among other factors, ribosomal recycling critically requires the NTPase ABCE1. However, several earlier reports have proposed that ABCE1 also somehow participates in the initiation complex assembly...
May 12, 2017: RNA Biology
https://www.readbyqxmd.com/read/28481852/baseline-t-classification-predicts-early-tumor-regrowth-after-nonoperative-management-in-distal-rectal-cancer-after-extended-neoadjuvant-chemoradiation-and-initial-complete-clinical-response
#11
Angelita Habr-Gama, Guilherme Pagin São Julião, Joaquim Gama-Rodrigues, Bruna Borba Vailati, Cinthia Ortega, Laura Melina Fernandez, Sérgio Eduardo Alonso Araújo, Rodrigo Oliva Perez
BACKGROUND: Selected patients with rectal cancer and complete clinical response after neoadjuvant chemoradiation have been managed nonoperatively with acceptable outcomes. However, ≈20% of these patients will develop early tumor regrowth. Identification of these patients could select candidates for more intensive follow-up. OBJECTIVE: The purpose of this study was to investigate the influence of baseline radiological T classification on recurrences after a complete clinical response managed nonoperatively after chemoradiation...
June 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28448642/inferior-survival-rates-after-chemoradiation-for-rectal-cancer-without-surgery
#12
Angelita Habr-Gama, Guilherme Pagin São Julião, Rodrigo O Perez
No abstract text is available yet for this article.
June 1, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28436197/magnetic-resonance-imaging-following-neoadjuvant-chemoradiation-and-transanal-endoscopic-microsurgery-for-rectal-cancer
#13
Guilherme P São Julião, Cinthia Denise Ortega, Bruna Borba Vailati, Angelita Habr-Gama, Laura Melina Fernandez, Joaquim Gama-Rodrigues, Sergio Eduardo Araujo, Rodrigo O Perez
AIM: Full thickness local excision after neoadjuvant chemoradiotherapy (CRT) for patients with rectal cancer and incomplete clinical response has been a treatment strategy for organ preservation. Follow up of these patients is challenging since anatomic distortion and postoperative changes may be clinically indistinguishable from tumor recurrence. Magnetic resonance imaging (MRI) may have a role in detecting recurrence. The aim of this study is to describe the MRI findings during follow-up in patients having local excision following CRT with and without local recurrence...
April 24, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28430975/behavioral-response-of-the-brown-marmorated-stink-bug-hemiptera-pentatomidae-to-semiochemicals-deployed-inside-and-outside-anthropogenic-structures-during-the-overwintering-period
#14
William R Morrison, Angelita Acebes-Doria, Emily Ogburn, Thomas P Kuhar, James F Walgenbach, J Christopher Bergh, Louis Nottingham, Anthony Dimeglio, Patricia Hipkins, Tracy C Leskey
The brown marmorated stink bug, Halyomorpha halys (Stål), is an invasive species from Asia capable of causing severe agricultural damage. It can also be a nuisance pest when it enters and exits anthropogenic overwintering sites. In recent years, pheromone lures and traps for H. halys have been developed and used to monitor populations in field studies. To date, no study has investigated the applicability of these monitoring tools for use indoors by building residents during the overwintering period. Herein, we 1) assessed when in late winter (diapause) and spring (postdiapause) H...
June 1, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28400922/pheochromocytoma-and-stress-cardiomyopathy-insight-into-pathogenesis
#15
Sahil Agrawal, Jamshid Shirani, Lohit Garg, Amitoj Singh, Santo Longo, Angelita Longo, Mark Fegley, Lauren Stone, Muhammad Razavi, Nicoleta Radoianu, Sudip Nanda
AIM: To investigate the occurrence of cardiomyopathy (CMP) in a cohort of patients with histologically proven pheochromocytoma (pheo), and to determine if catecholamine excess was causative of the left ventricular (LV) dysfunction. METHODS: A retrospective chart review spanning years 1998 through 2014 was undertaken and patients with a diagnosis of pheo confirmed with histopathologic examination were included. Presenting electrocardiograms and cardiac imaging studies were reviewed...
March 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28334178/inter-regional-variations-in-gene-expression-and-age-related-cortical-thinning-in-the-adolescent-brain
#16
Angelita Pui-Yee Wong, Leon French, Gabriel Leonard, Michel Perron, G Bruce Pike, Louis Richer, Suzanne Veillette, Zdenka Pausova, Tomáš Paus
Age-related decreases in cortical thickness observed during adolescence may be related to fluctuations in sex and stress hormones. We examine this possibility by relating inter-regional variations in age-related cortical thinning (data from the Saguenay Youth Study) to inter-regional variations in expression levels of relevant genes (data from the Allen Human Brain Atlas); we focus on genes coding for glucocorticoid receptor (NR3C1), androgen receptor (AR), progesterone receptor (PGR), and estrogen receptors (ESR1 and ESR2)...
February 25, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28265736/extralevator-abdominal-perineal-excision-versus-standard-abdominal-perineal-excision-impact-on-quality-of-the-resected-specimen-and-postoperative-morbidity
#17
Angelita Habr-Gama, Guilherme P São Julião, Adrian Mattacheo, Luiz Felipe de Campos-Lobato, Edgar Aleman, Bruna B Vailati, Joaquim Gama-Rodrigues, Rodrigo Oliva Perez
BACKGROUND: Abdominal perineal excision (APE) has been associated with a high risk of positive circumferential resection margin (CRM+) and local recurrence rates in the treatment of rectal cancer. An alternative extralevator approach (ELAPE) has been suggested to improve the quality of resection by avoiding coning of the specimen decreasing the risk of tumor perforation and CRM+. The aim of this study is to compare the quality of the resected specimen and postoperative complication rates between ELAPE and "standard" APE...
March 6, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28241775/rigorous-evaluation-of-a-pregnancy-prevention-program-for-american-indian-youth-and-adolescents-study-protocol-for-a-randomized-controlled-trial
#18
Lauren Tingey, Rachel Chambers, Novalene Goklish, Francene Larzelere, Angelita Lee, Rosemarie Suttle, Summer Rosenstock, Kristin Lake, Allison Barlow
BACKGROUND: American Indian adolescents have one of the highest rates of teen pregnancy and repeat teen births in the US. Substance use is a significant risk factor for unprotected sex, and American Indian adolescents have the highest substance use-related morbidity and mortality of any US racial group. Despite these disparities, there are no existing, evidence-based programs for pregnancy prevention that have been rigorously evaluated among American Indian teens. METHODS: The proposed study is a randomized controlled trial to test the efficacy of a comprehensive sexual and reproductive health program developed in partnership with an American Indian community...
February 27, 2017: Trials
https://www.readbyqxmd.com/read/28230754/green-hydroselenation-of-aryl-alkynes-divinyl-selenides-as-a-precursor-of-resveratrol
#19
Gelson Perin, Angelita M Barcellos, Eduardo Q Luz, Elton L Borges, Raquel G Jacob, Eder J Lenardão, Luca Sancineto, Claudio Santi
A simple and efficient protocol to prepare divinyl selenides has been developed by the regio- and stereoselective addition of sodium selenide species to aryl alkynes. The nucleophilic species was generates in situ, from the reaction of elemental selenium with NaBH₄, utilizing PEG-400 as the solvent. Several divinyl selenides were obtained in moderate to excellent yields with selectivity for the (Z,Z)-isomer by a one-step procedure that was carried out at 60 °C in short reaction times. The methodology was extended to tellurium, giving the desired divinyl tellurides in good yields...
February 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28218968/structural-thermal-physical-mechanical-and-barrier-properties-of-chitosan-films-with-the-addition-of-xanthan-gum
#20
Maria de Morais Lima, Lucia Cesar Carneiro, Daniela Bianchini, Alvaro Renato Guerra Dias, Elessandra da Rosa Zavareze, Carlos Prentice, Angelita da Silveira Moreira
Films based on chitosan and xanthan gum were prepared using casting technique aiming to investigate the potential of these polymers as packaging materials. Six formulations of films were studied varying the proportion of chitosan and xanthan gum: 100:0 (chitosan:xanthan gum, w/w, C100XG0 film); 90:10 (chitosan:xanthan gum, w/w, C90XG10 film); 80:20 (chitosan:xanthan gum, w/w, C80XG20 film); 70:30 (chitosan:xanthan gum, w/w, C70XG30 film); 60:40 (chitosan:xanthan gum, w/w, C60XG40 film); and 50:50 (chitosan:xanthan gum, w/w, C50XG50 film)...
March 2017: Journal of Food Science
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