Fumin Jia, Jianguo Zhang, Huimin Wang, Zhanhua Liang, Weiguo Liu, Xuelian Wang, Yiming Liu, Yi Guo, Zhipei Ling, Xiaodong Cai, Xi Wu, Jianjun Wu, Wen Lv, Xin Xu, Wenbin Zhang, Luming Li
BACKGROUND: Deep-brain stimulation targeting the subthalamic nucleus (STN) can be used to treat motor symptoms and dyskinesia in the advanced stages of Parkinson's disease (PD). High-frequency stimulation (HFS) of the STN can lead to consistent, long-term improvement of PD symptoms. However, the effects of HFS on the axial symptoms of PD, specifically freezing of gait, can be limited or cause further impairment. While this can be alleviated via relatively low-frequency stimulation (LFS) in selected patients, LFS does not control all motor symptoms of PD...
December 19, 2019: Trials