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https://www.readbyqxmd.com/read/28741635/liposomes-loading-sodium-chloride-as-effective-thermo-seeds-for-microwave-ablation-of-hepatocellular-carcinoma
#1
Qunfang Zhou, Songsong Wu, Ningqiang Gong, Xin Li, Jianping Dou, Mengjuan Mu, Xiaoling Yu, Jie Yu, Ping Liang
Microwave ablation (MWA) is a promising minimally invasive therapy that has been widely used to treat hepatocellular carcinoma (HCC). However, the efficiency of MWA in treating HCC is evidently limited by the incomplete ablation of large tumors and tumors in high-risk locations. Here, we report the value of using liposomes packed with sodium chloride (NaCl-LPs) as effective thermo-seeds for MWA of HCC. The prepared liposomes exhibited excellent heat conversion ability by showing a more rapid temperature increase than free NaCl medium, blank liposomes or water under microwave irradiation...
July 25, 2017: Nanoscale
https://www.readbyqxmd.com/read/28741377/renal-cell-carcinoma-alternative-nephron-sparing-treatment-options-for-small-renal-masses-a-systematic-review
#2
Fieke M Prins, Linda G W Kerkmeijer, Anne A Pronk, Evert-Jan P A Vonken, Richard P Meijer, Axel Bex, Maurits M Barendrecht
<i>Background</i> The standard treatment of T1 renal cell carcinoma is (partial-) nephrectomy. For patients where surgery is not the treatment of choice, for example in the elderly, in case of severe comorbidity, inoperability or refusal of surgery, alternative treatment options are available. These treatment options include active surveillance, radiofrequency ablation, cryoablation, microwave ablation or stereotactic body radiotherapy. In the present overview, the efficacy, safety and outcome of these different options are summarized, particularly focusing on recent developments...
July 25, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28733518/ultrasound-guided-percutaneous-microwave-ablation-assisted-by-three-dimensional-visualization-operative-treatment-planning-system-and-percutaneous-transhepatic-cholangial-drainage-with-intraductal-chilled-saline-perfusion-for-larger-hepatic-hilum-hepatoce
#3
Xin Li, Jie Yu, Ping Liang, Xiaoling Yu, Zhigang Cheng, Zhiyu Han, Shaobo Duan, Jiasheng Zheng
To assess the clinical efficiency of ultrasound-guided percutaneous microwave ablation (US-PMWA) assisted by three-dimensional (3D) visualization operative treatment planning system and percutaneous transhepatic cholangial drainage with intraductal chilled saline perfusion (PTCD-ICSP) for larger hepatic hilum hepatocellular carcinoma (HH-HCC) (D ≥ 3 cm). The combination therapy was performed in 14 patients from Sep 2011 to May 2017. The major outcomes for assessment were biliary duct complications, local tumor recurrence, distant recurrence and overall survival rates...
July 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28730773/thermal-ablation-may-improve-outcomes-in-patients-with-colorectal-liver-metastasis-a-case-control-study
#4
Loukia S Poulou, Loukas Thanos, Panayiotis D Ziakas, Emmanouel Merikas, Apostolos Achimastos, Constantine Gennatas, Konstantinos N Syrigos
PURPOSE: Local thermal ablation may extend the scope of palliative therapy in patients with colorectal liver metastasis. We performed a retrospective, case-controlled study to compare patients with colorectal liver metastases that were treated with percutaneous radiofrequency (RF) or microwave (MW) thermal ablation, against the control group of chemotherapy alone. METHODS: We described baseline demographics, ablation sessions, procedure duration and related complications...
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28730772/a-comparative-study-of-laparoscopic-microwave-ablation-with-laparoscopic-radiofrequency-ablation-for-colorectal-liver-metastasis
#5
Bo Yang, Yuwei Li
PURPOSE: Laparoscopic thermal ablation is a common alternative to surgical resection for treating colorectal liver metastasis, particularly for metastases located in difficult-to-reach regions. This study aimed to compare the short- and longterm outcomes of laparoscopic radiofrequency ablation (LRFA) and laparoscopic microwave ablation (LMWA) used for treating colorectal liver metastasis. METHODS: Data from patients with colorectal liver metastasis who had undergone LRFA or LMWA from January 2010 to January 2016 were examined...
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28728304/-percutaneous-microwave-radiofrequency-ablation-liver-partition-and-portal-vein-embolization-for-planned-hepatectomy-for-colorectal-liver-metastases-with-insufficient-future-liver-remnant
#6
Y B Zhang, D F Hong, X M Fan, Z Y Luo, G L Shen
No abstract text is available yet for this article.
July 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28721494/a-comprehensive-characterization-of-parameters-affecting-high-frequency-irreversible-electroporation-lesions
#7
Tyler Miklovic, Eduardo L Latouche, Matthew R DeWitt, Rafael V Davalos, Michael B Sano
Several focal therapies are being investigated clinically to treat tumors in which surgery is contraindicated. Many of these ablation techniques, such as radiofrequency ablation and microwave ablation, rely on thermal damage mechanisms which can put critical nerves or vasculature at risk. Irreversible electroporation (IRE) is a minimally invasive, non-thermal technique to destroy tumors. A series of short electric pulses create nanoscale defects in the cell membrane, eventually leading to cell death. Typical IRE protocols deliver a series of 50-100 µs monopolar pulses...
July 18, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28707652/thermal-ablation-in-the-management-of-adrenal-metastasis-originating-from-non-small-cell-lung-cancer-a-5-year-single-center-experience
#8
Evanthia I Botsa, Ioanna L Thanou, Aspasia T Papatheodoropoulou, Loukas I Thanos
BACKGROUND: Treatment of adrenal metastasis from lung carcinoma may prolong survival in the selected patients. However, not all patients can undergo surgery; thus, minimally invasive ablation procedures such as radiofrequency ablation (RFA) and microwave ablation (MWA) have gained acceptance as alternative treatment methods. This study summarized a 5-year single-center experience regarding the evaluation of safety and efficacy of computed tomography (CT)-guided thermal ablation in the management of adrenal metastasis originating from non-small cell lung cancer (NSCLC)...
July 13, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28701568/feasibility-and-efficacy-of-microwave-ablation-combined-with-iodine-125-seed-implantation-in-local-control-of-recurrent-retroperitoneal-liposarcomas-initial-clinical-experience
#9
Mingjian Lu, Wang Yao, Tao Zhang, Wenzhe Fan, Zhihui Zhong, Jiaping Li, Fujun Zhang
INTRODUCTION: The objective of the present study was to evaluate the feasibility, safety, and short-term efficacy of microwave ablation (MWA) combined with iodine-125 ((125)I) seed implantation in recurrent retroperitoneal liposarcomas (rRPLs). MATERIALS AND METHODS: From September 2012 to March 2015, 11 patients were enrolled in this prospective study. Eleven tumors (median, 9 cm; range, 5.5-12.5 cm) were treated with computerized tomography-guided MWA for 11 sessions and (125)I seed implantation for 18 sessions...
July 12, 2017: Oncologist
https://www.readbyqxmd.com/read/28693505/effects-of-radiofrequency-ablation-versus-other-ablating-techniques-on-hepatocellular-carcinomas-a-systematic-review-and-meta-analysis
#10
Wen Luo, Yunfei Zhang, Guangbin He, Ming Yu, Minjuan Zheng, Liwen Liu, Xiaodong Zhou
BACKGROUND: Percutaneous ablation has quickly arisen as one of the important alternative treatments for hepatocellular carcinoma (HCC). We aimed to compare the therapeutic effects of radiofrequency ablation (RFA) and other ablative techniques on HCCs. METHODS: Databases were searched to identify literature on complete tumor ablation (CTA), overall survival (OS), local tumor recurrence (LTR), and complications of RFA in the treatment of HCC, compared with those of microwave ablation (MWA), percutaneous ethanol injection (PEI), PEI plus RFA, cryoablation (CRA), laser ablation (LSA), and high-intensity focused ultrasound...
July 10, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28688254/monitoring-ice-variations-in-qinghai-lake-from-1979-to-2016-using-passive-microwave-remote-sensing-data
#11
Yu Cai, Chang-Qing Ke, Zheng Duan
Lake ice is a sensitive indicator of climate change. Based on the disparities between the brightness temperatures of lake ice and water, passive microwave data can be used to monitor the ice variations of a lake. With focus on the analysis of long time series variability of lake ice, this study extracts four characteristic dates related to lake ice (the annual freeze start, freeze completion, ablation start and ablation completion dates) for Qinghai Lake from 1979 to 2016 using Scanning Multichannel Microwave Radiometer (SMMR) and Special Sensor Microwave Imager (SSM/I) passive microwave brightness temperature data...
July 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28685607/state-of-the-ablation-nation-a-review-of-ablative-therapies-for-cure-in-the-treatment-of-hepatocellular-carcinoma
#12
Umer Salati, Aisling Barry, Frank Y Chou, Roy Ma, David M Liu
Primary liver cancer, mainly hepatocellular carcinoma, is one of the most common malignancies worldwide. Surgical management, either resection or transplantation, is considered definitive treatment, however, less than 20% of patients are ultimately candidates. Thermal ablation modalities such as radiofrequency ablation and microwave ablation have evolved such that these modalities have been applied with curative intent. Moreover, thermal ablation has demonstrated efficacy in treating early-stage tumors and can be offered as first-line treatment in patients with uncomplicated disease...
July 7, 2017: Future Oncology
https://www.readbyqxmd.com/read/28682866/efficacy-and-safety-of-ultrasound-guided-percutaneous-microwave-ablation-for-the-treatment-of-hepatic-alveolar-echinococcosis-a-preliminary-study
#13
Yangdan Cairang, Lingqiang Zhang, Bin Ren, Li Ren, Lizhao Hou, Haijiu Wang, Ying Zhou, Qingxi Zhang, Jun Shao, Haining Fan
The present study aims to assess the efficacy and safety of ultrasound-guided percutaneous microwave ablation (MWA) for hepatic alveolar echinococcosis (HAE) preliminarily.Seventeen patients diagnosed to HAE and treated with MWA (80 watts, 4 min) were retrospectively analyzed. The upper abdominal computed tomography (CT) was performed at 1, 6, 12 months after the MWA treatment. The complications were evaluated to assess the safety.The diameters of the lesions in the HAE patients ranged from 1.9 to 4.7 cm...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28681222/transarterial-chemoembolization-monotherapy-versus-combined-transarterial-chemoembolization-microwave-ablation-therapy-for-hepatocellular-carcinoma-tumors-%C3%A2-5%C3%A2-cm-a-propensity-analysis-at-a-single-center
#14
Qi-Feng Chen, Zhen-Yu Jia, Zheng-Qiang Yang, Wen-Long Fan, Hai-Bin Shi
PURPOSE: To compare effectiveness of transarterial chemoembolization (TACE) combined with microwave ablation (MWA; TACE-MWA) with TACE alone for treating hepatocellular carcinoma (HCC) tumors ≤5 cm. MATERIALS AND METHODS: We reviewed data of 244 patients treated for HCC by TACE-MWA or TACE from June 2014 to December 2015. Median follow-up period was 505 days (TACE-MWA group: 485 days; TACE group: 542 days). Patients were propensity score matched (1:2 ratio); outcomes of TACE-MWA and TACE groups were compared...
July 5, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28680636/ablative-techniques-for-the-treatment-of-benign-and-malignant-breast-tumours
#15
REVIEW
Mirjam C L Peek, Michael Douek
Minimally invasive techniques like high intensity focused ultrasound, radiofrequency ablation, cryo-ablation, laser ablation and microwave ablation have been used to treat both breast fibroadenomata and breast cancer as an alternative to surgical excision, potentially reducing the complications, improving cosmesis and reducing hospital stay. This review describes the most common minimally invasive techniques available, their history and some of the studies performed with these techniques in both benign and malignant lesions...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28678756/does-primary-tumor-location-impact-the-prognosis-of-colorectal-liver-metastases-patients-after-microwave-ablation-lessons-from-10-years-experience
#16
REVIEW
Fubo Zhou, Xiaoling Yu, Ping Liang, Zhiyu Han, Zhigang Cheng, Jie Yu, Fangyi Liu, Yi Hu
Thermal ablation has been considered as an alternative for local curative intent in patients with unresectable colorectal liver metastases. The influence of primary tumor location on the prognosis of colorectal liver metastases patients who have undergone microwave ablation has yet to be determined. We reviewed 295 patients who underwent microwave ablation for colorectal liver metastases at our institution between March 2006 and March 2016. Univariate and multivariate analyses were performed to identify predictors of overall and progression-free survival...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28678572/percutaneous-image-guided-thermal-ablation-for-multifocal-renal-cell-carcinoma-10-year-experience-at-a-single-center
#17
Wenhui Zhou, Raul N Uppot, Adam S Feldman, Ronald S Arellano
OBJECTIVE: The objective of our study was to assess the technical success, safety, and oncologic and renal function outcomes of CT-guided percutaneous thermal ablation for synchronous multiple renal masses in a single session. MATERIALS AND METHODS: A retrospective analysis of 23 patients (16 men and 7 women; median age, 70 years) with biopsy-proven multifocal renal cell carcinoma (RCC) masses treated with radiofrequency ablation (RFA), cryoablation, or microwave ablation (MWA) was performed...
July 5, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28673652/innovation-best-practices-in-the-medical-device-industry
#18
Partha P Ray, Joseph F Amaral, Piet Hinoul
Advances in patient care often germinate from keen clinical insights and a needs-based approach to innovation. Although there is an important role for incremental improvements to existing solutions, transformational innovation is what truly drives real shifts in clinical outcomes and subsequently patient satisfaction, market access, and economic value. A good example of this is the evolution of the coronary stent market. The best innovation programs are focused on unmet needs rather than solutions, call for a careful articulation of the specific problems to be solved, involve a deep dive within a clinical area, and seek to prioritize research and development investments into areas where the greatest impact can be expected...
June 2017: Techniques in Vascular and Interventional Radiology
https://www.readbyqxmd.com/read/28657845/the-role-of-percutaneous-image-guided-thermal-ablation-for-the-treatment-of-pulmonary-malignancies
#19
Samdeep K Mouli, Ieva Kurilova, Constantinos T Sofocleous, Robert J Lewandowski
OBJECTIVE: Image-guided thermal ablation is a minimally invasive treatment option for patients with primary and secondary pulmonary malignancies. Modalities include radiofrequency ablation, microwave ablation, and cryoablation. CONCLUSION: Although no large randomized studies exist comparing ablation to surgery or radiotherapy, numerous studies have reported safety and efficacy for the treatment of both primary and metastatic disease in select patients. Future studies will refine patient selection, procedural technique, and assessment for local recurrence and will evaluate long-term survival...
June 28, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28651746/the-management-of-colorectal-liver-metastases
#20
B Maher, E Ryan, M Little, P Boardman, B Stedman
Colorectal cancer remains a leading cause of cancer-related death in Europe. Approximately one-quarter of patients have synchronous hepatic metastases and metachronous liver metastases occur in a further 30%. The scope of surgery in management of colorectal metastases has evolved to include selected patients with extra-hepatic disease for whom R0 resection is considered feasible; however, locoregional treatments are increasingly recognised as viable management options in those patients deemed unsuitable for surgery and there is an expanding body of evidence regarding their ability to achieve local control and increase progression-free survival in the liver...
August 2017: Clinical Radiology
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