Leonardo A Mesquita, Bernardo F Spiazzi, Giovana F Piccoli, Daniela A Nogara, Gabriella R da Natividade, Henrique I Garbin, Laura F Wayerbacher, Vanessa M Wiercinski, Viviane A Baggio, Carolina P Zingano, Gilberto Schwartsmann, Gilberto Lopes, John R Petrie, Verônica Colpani, Fernando Gerchman
AIM: To evaluate the effect of metformin on cancer incidence in subjects with overweight/obesity and/or prediabetes/diabetes. MATERIALS AND METHODS: We searched MEDLINE, Embase and CENTRAL for randomized controlled trials (RCTs) in adults with overweight/obesity and/or prediabetes/diabetes that compared metformin to other interventions for ≥24 weeks. Independent reviewers selected and extracted data including population and intervention characteristics and new diagnoses of cancer...
February 23, 2024: Diabetes, Obesity & Metabolism