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https://www.readbyqxmd.com/read/28343365/sox10-immunohistochemistry-in-sweat-ductal-glandular-neoplasms
#1
David S Cassarino, Albert Su, Bruce A Robbins, David Altree-Tacha, Seong Ra
BACKGROUND: SOX10 is a newer Schwannian and melanocytic marker that has generated great interest for its relative sensitivity and specificity in the diagnosis of neural crest-derived tumors. Previous studies with SOX10 have shown positive immunohistochemical expression in cutaneous eccrine glands and negative expression in eccrine ducts, apocrine glands, and hair follicles. Thus, we hypothesized that some sweat gland tumors of presumed eccrine origin would be positive for SOX10, whereas apocrine-derived sweat gland tumors would not...
March 25, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28330446/eudor-a-multi-centre-research-program-a-naturalistic-european-multi-centre-clinical-study-of-edor-test-in-adult-patients-with-primary-depression
#2
Marco Sarchiapone, Miriam Iosue, Vladimir Carli, Mario Amore, Enrique Baca-Garcia, Anil Batra, Doina Cosman, Philippe Courtet, Guido Di Sciascio, Ricardo Gusmao, Tadeusz Parnowski, Peter Pestality, Pilar Saiz, Johannes Thome, Anders Tingström, Marcin Wojnar, Patrizia Zeppegno, Lars-Håkan Thorell
BACKGROUND: Electrodermal reactivity has been successfully used as indicator of interest, curiosity as well as depressive states. The measured reactivity depends on the quantity of sweat secreted by those eccrine sweat glands that are located in the hypodermis of palmar and plantar regions. Electrodermal hyporeactive individuals are those who show an unusual rapid habituation to identical non-significant stimuli. Previous findings suggested that electrodermal hyporeactivity has a high sensitivity and a high specificity for suicide...
March 23, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28300854/randomized-placebo-and-active-controlled-crossover-study-of-the-safety-and-efficacy-of-thvd-102-a-fixed-dose-combination-of-oxybutynin-and-pilocarpine-in-subjects-with-primary-focal-hyperhidrosis
#3
David M Pariser, Janakan Krishnaraja, Thomas M Tremblay, R Michael Rubison, Ted W Love, Benjamin F McGraw
BACKGROUND: While muscarinic antagonists (anticholinergics) have shown efficacy in treating primary focal hyperhidrosis (PFH), side effects - most commonly dry mouth - are intolerable for most patients. THVD-102, a fixed-dose combination product has been developed combining oxybutynin, a muscarinic antagonist, and pilocarpine, a muscarinic agonist. The pilocarpine is at a dose level and release profile optimized to correct salivary flow impaired by oxybutynin yet not interfere with the therapeutic muscarinic antagonist effect of oxybutynin upon the sweat glands...
February 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28299221/endocrine-mucin-producing-sweat-gland-carcinoma-a-histological-challenge
#4
Mary Anne Brett, Samih Salama, Gabriella Gohla, Salem Alowami
Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare adnexal tumor of the skin with low-grade cytological features and neuroendocrine differentiation. It has a predilection for the skin of the eyelid, but has also been reported in the face and rarely extra-facial locations. The tumor is seen more frequently in women and on average affects the elderly. It is histologically and immunohistochemically analogous to solid papillary carcinoma of the breast/endocrine ductal carcinoma in situ with a nodular, solid, papillary, and/or cribriforming architecture, neuroendocrine differentiation, and mucin production...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28297138/a-novel-homozygous-missense-mutation-in-hoxc13-leads-to-autosomal-recessive-pure-hair-and-nail-ectodermal-dysplasia
#5
Xiaoxiao Li, Meredith Lee Orseth, J Michael Smith, Mary Abigail Brehm, Nnenna Gebechi Agim, Donald Alexander Glass
Pure hair and nail ectodermal dysplasia (PHNED) is a rare disorder that presents with hypotrichosis and nail dystrophy while sparing other ectodermal structures such as teeth and sweat glands. We describe a homozygous novel missense mutation in the HOXC13 gene that resulted in autosomal recessive PHNED in a Hispanic child. The mutation c.812A>G (p.Gln271Arg) is located within the DNA-binding domain of the HOXC13 gene, cosegregates within the family, and is predicted to be maximally damaging. This is the first reported case of a missense HOXC13 mutation resulting in PHNED and the first reported case of PHNED identified in a North American family...
March 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28295553/serum-carcinoembryonic-antigen-specifically-increases-among-various-serum-markers-of-adenocarcinoma-in-hypohidrosis-or-conditions-related-to-hypohidrosis
#6
Masaru Honma, Hiroyoshi Nozaki, Hiroko Nagahata, Mizue Fujii, Takashi Shibuya, Kyoko Kanno, Masako Minami-Hori, Akemi Ishida-Yamamoto
Anhidrosis/hypohidrosis are conditions presenting various level of sweating dysfunction. Among them, acquired idiopathic generalized anhidrosis (AIGA) presents inadequate decrease or loss of sweating without apparent neurological and dermatological symptoms except cholinergic urticaria. Recently, serum level of carcinoembryonic antigen (CEA), one of the most well-known tumor markers, has been proposed as a clinical marker reflecting activity of AIGA. This study was performed to verify the specificity and independence of serum CEA level from the other serum tumor markers especially related to adenocarcinoma...
March 11, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28286062/mirnas-are-required-for-post-induction-stage-sweat-gland-development
#7
Chang-Yi Cui, Yulan Piao, Dean P Campbell, Ryuga Ishii, Marc Michel, Alexei Sharov, David Schlessinger
No abstract text is available yet for this article.
March 9, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28285811/-composite-pheochromocytoma-a-rare-adrenal-tumor
#8
Gwladys Robinet, Nathalie Rioux-Leclercq, Andréa Manunta, Romain Mathieu, Frédérique Tissier, Benoit Peyronnet, Solène-Florence Kammerer-Jacquet
INTRODUCTION: Composite pheochromocytoma is a rare tumor of the adrenal medulla composed of pheochromocytoma and neuroblastic tumor. We report the case of a composite pheochromocytoma detected in a patient with neurofibromatosis type 1. CASE REPORT: A 61-year-old male patient presented occasional sweats with palpitation and moderate high blood pressure. Urinary catecholamine level was increased. CT scan showed a heterogeneous tumor limited to the adrenal gland. Histologically, the tumor showed two components: pheochromocytoma and ganglioneuroma and was diagnosed as a composite pheochromocytoma...
March 9, 2017: Annales de Pathologie
https://www.readbyqxmd.com/read/28277254/-malignant-transformation-of-an-eccrine-spiradenoma
#9
J Jacquemus, S Dalle, M Faure, B Chouvet, O Beatrix, B Balme
INTRODUCTION: Malignant eccrine spiradenoma is a rare and aggressive tumor, developed on the epithelium of eccrine sweat glands. Typically, it occurs after malignant transformation of benign eccrine spiradenoma, but sometimes it happens de novo. OBSERVATION: We report a case of malignant eccrine spiradenoma in a 62-year-old woman. The patient presented a rapid increase in size of a long-standing tumoral lesion of her forearm. There was no secondary lesion on the chest, abdomen or pelvis at the CT-scanner...
March 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28269142/dynamic-analysis-of-mental-sweating-of-eccrine-sweat-gland-of-human-fingertip-by-time-sequential-piled-up-en-face-optical-coherence-tomography-images
#10
Masato Ohmi, Yuki Wada
In this paper, we demonstrate dynamic analysis of mental sweating for sound stimulus of a few tens of eccrine sweat glands by the time-sequential piled-up en face optical coherence tomography (OCT) images with the frame spacing of 3.3 sec. In the experiment, the amount of excess sweat can be evaluated simultaneously for a few tens of sweat glands by piling up of all the en face OCT images. Non-uniformity was observed in mental sweating where the amount of sweat in response to sound stimulus is different for each sweat gland...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28258566/aquaporins-and-gland-secretion
#11
Christine Delporte
Aquaporins (AQPs ) are expressed in most exocrine and endocrine secretory glands. Consequently, summarizing the expression and functions of AQPs in secretory glands represents a daunting task considering the important number of glands present in the body, as well as the number of mammalian AQPs - thirteen. The roles played by AQPs in secretory processes have been investigated in many secretory glands. However, despite considerable research, additional studies are clearly needed to pursue our understanding of the role played by AQPs in secretory processes...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28256768/topics-in-histopathology-of-sweat-gland-and-sebaceous-neoplasms
#12
REVIEW
Shin-Ichi Ansai
This article reviews several topics regarding sweat gland and sebaceous neoplasms. First, the clinicopathological characteristics of poroid neoplasms are summarized. It was recently reported that one-fourth of poroid neoplasms are composite tumors and one-fourth are apocrine type lesions. Recent progress in the immunohistochemical diagnosis of sweat gland neoplasms is also reviewed. CD117 can help to distinguish sweat gland or sebaceous tumors from other non-Merkel cell epithelial tumors of the skin. For immunohistochemical differential diagnosis between sweat gland carcinoma (SGC) other than primary cutanesous apocrine carcinoma and skin metastasis of breast carcinoma (SMBC), a panel of antibodies may be useful, including p63 (SGC(+) , SMBC(-) ), CK5/6 (SGC(+) , SMBC(-) ), podoplanin (SGC(+) , SMBC(-) ) and mammaglobin (SGC(-) , SMBC(+) )...
March 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28251170/presentation-of-massive-orbital-hidrocystoma-at-birth-case-report-and-review-of-the-literature
#13
Bahram Eshraghi, Mohammad-Ali Abtahi, Seyed Ali Sonbolastan, Zahra Kasaie, Seyed-Hossein Abtahi
BACKGROUND: Hidrocystoma, or sudoriferous cyst, is an eyelid tumor originating from apocrine or eccrine sweat glands. Its presence in the orbit is relatively rare. CASE PRESENTATION: A full-term female child with severe right eye extrusion was referred to our department two hours after birth. We performed cyst aspiration under ultrasonic guidance; 15 cc straw-colored fluid was obtained and proptosis resolved significantly. Orbital magnetic resonance imaging (MRI) showed a large unilocular retrobulbar mass with hypo-intensity in T1 and hyper-intensity in T2...
2017: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/28240705/skin-tattoos-alter-sweat-rate-and-na-concentration
#14
Maurie Joe Luetkemeier, Joseph Michael Hanisko, Kyle Mathiew Aho
The popularity of tattoos has increased tremendously in the last 10-years particularly among athletes and military personnel. The tattooing process involves permanently depositing ink under the skin at a similar depth as eccrine sweat glands (3-5 mm). PURPOSE: The purpose of this study was to compare the sweat rate and sweat Na concentration of tattooed vs. non-tattooed skin. METHODS: The participants were 10 healthy males (age = 21 ± 1 yr) all with a unilateral tattoo covering a circular area at least 5...
February 25, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28227371/dynamic-analysis-of-mental-sweating-of-eccrine-sweat-gland-of-human-fingertip-by-time-sequential-piled-up-en-face-optical-coherence-tomography-images
#15
Masato Ohmi, Yuki Wada, Masato Ohmi, Yuki Wada, Masato Ohmi, Yuki Wada
In this paper, we demonstrate dynamic analysis of mental sweating for sound stimulus of a few tens of eccrine sweat glands by the time-sequential piled-up en face optical coherence tomography (OCT) images with the frame spacing of 3.3 sec. In the experiment, the amount of excess sweat can be evaluated simultaneously for a few tens of sweat glands by piling up of all the en face OCT images. Non-uniformity was observed in mental sweating where the amount of sweat in response to sound stimulus is different for each sweat gland...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28219137/-analysis-of-the-application-and-funding-projects-of-national-natural-science-foundation-of-china-in-the-field-of-burns-and-plastic-surgery-from-2010-to-2016
#16
Z C Zhang, D Dou, X Y Wang, D H Xie, Z C Yan
We analyzed the data of application and funding projects of the National Natural Science Foundation of China (NSFC) during 2010-2016 in the field of burns and plastic surgery and summarized the NSFC funding pattern, the research hotspots, and weaknesses in this field. The NSFC has funded 460 projects in the field of burns and plastic surgery, with total funding of RMB 227.96 million. The scientific issues involved in the funding projects include orthotherapy against malformations, wound repair, basic research of burns, skin grafting, scars prevention, and regeneration of hair follicle and sweat glands...
February 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28212277/clinical-and-molecular-evidence-of-abcc11-protein-expression-in-axillary-apocrine-glands-of-patients-with-axillary-osmidrosis
#17
Yu Toyoda, Tappei Takada, Tsuneaki Gomi, Hiroshi Nakagawa, Toshihisa Ishikawa, Hiroshi Suzuki
Accumulating evidence suggests that the risk of axillary osmidrosis is governed by a non-synonymous single nucleotide polymorphism (SNP) 538G>A in human ATP-binding cassette C11 (ABCC11) gene. However, little data are available for the expression of ABCC11 protein in human axillary apocrine glands that produce apocrine sweat-a source of odor from the armpits. To determine the effect of the non-synonymous SNP ABCC11 538G>A (G180R) on the ABCC11 in vivo, we generated transiently ABCC11-expressing transgenic mice with adenovirus vector, and examined the protein levels of each ABCC11 in the mice with immunoblotting using an anti-ABCC11 antibody we have generated in the present study...
February 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28209107/gastro-intestinal-manifestations-in-cystic-fibrosis-patients
#18
REVIEW
S Van Biervliet, C de Clercq, D Declercq, E Van Braeckel, S Van Daele, F De Baets, D De Looze
Cystic fibrosis (CF) is a life-limiting disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR). This defective chloride channel, present in different organ systems such as respiratory system, gastrointestinal tract, reproductive system and sweat glands, disturbs the ion and water transport over the membranes leading to the well known CF symptoms. CF has outgrown paediatric care, as half of CF patients are currently adults. The CF gastrointestinal tract has its own particularities...
September 2016: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/28202441/effect-of-hypohydration-on-postsynaptic-cutaneous-vasodilation-and-sweating-in-healthy-men
#19
Matthew A Tucker, Ashley Six, Nicole E Moyen, Alf Z Satterfield, Matthew S Ganio
Hypohydration decreases cutaneous vasodilation and sweating during heat stress, but it is unknown if these decrements are from postsynaptic (i.e. sweat gland/blood vessel) alterations. PURPOSE: To determine if hypohydration affects postsynaptic cutaneous vasodilation and sweating responses. METHODS: 12 healthy men participated in euhydrated (EU) and hypohydrated (HY) trials, with hypohydration induced via fluid restriction and passive heat-stress. Changes in cutaneous vascular conductance (CVC; %max) in response to incremental intradermal infusion of the endothelium-independent vasodilator sodium nitroprusside (SNP) and the endothelium-dependent vasodilator methacholine chloride (MCh) were assessed by laser Doppler flowmetry...
February 15, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28190856/virilism-and-ectopic-expression-of-hsd17b5-in-mature-cystic-teratoma
#20
Yohei Kawaguchi, Hiroko Mizuno, Mai Horikawa, Mayuko Kano, Kengo Yamada, Fumiko Yamakawa, Takashi Maekawa, Yuto Yamazaki, Keely M McNamara, Hironobu Sasano, Masayuki Hayashi
Mature cystic teratoma (MCT) is rarely involved in the overproduction of steroid hormones in contrast to sex cord stromal tumors. A 31-year-old woman visited our hospital with hirsutism, hoarseness, and hair loss from the scalp. Serum testosterone and free-testosterone levels were 7.3 ng/ml and 2.3 pg/ml, respectively, which were markedly in excess of the age adjusted female standard levels. Basal blood levels of steroid hormones and serum levels of 17-hydroxyprogesterone at 1 h after intravenous injection of adrenocorticotropic hormone demonstrated that 21-hydroxylase deficiency was not the underlying cause of her virilization...
2017: Tohoku Journal of Experimental Medicine
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