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https://www.readbyqxmd.com/read/28105745/thin-soft-skin-mounted-microfluidic-networks-with-capillary-bursting-valves-for-chrono-sampling-of-sweat
#1
Jungil Choi, Daeshik Kang, Seungyong Han, Sung Bong Kim, John A Rogers
Systems for time sequential capture of microliter volumes of sweat released from targeted regions of the skin offer the potential to enable analysis of temporal variations in electrolyte balance and biomarker concentration throughout a period of interest. Current methods that rely on absorbent pads taped to the skin do not offer the ease of use in sweat capture needed for quantitative tracking; emerging classes of electronic wearable sweat analysis systems do not directly manage sweat-induced fluid flows for sample isolation...
January 20, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28103991/-study-on-sweat-gland-regeneration-induced-by-microenvironment-of-three-dimensional-bioprinting
#2
B Yao, J F Xie, S Huang, X B Fu
Sweat glands are abundant in the body surface and essential for thermoregulation. Sweat glands fail to conduct self-repair in patients with large area of burn and trauma, and the body temperature of patients increases in hot climate, which may cause shock or even death. Now, co-culture system, reprogramming, and tissue engineering have made progresses in inducing sweat gland regeneration, but the inductive efficiency and duration need to be improved. Cellular microenvironment can regulate cell biological behavior, including cell migration and cell differentiation...
January 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28098399/myb-cd117-and-sox-10-expression-in-cutaneous-adnexal-tumors
#3
Mara Therese P Evangelista, Jeffrey P North
BACKGROUND: Elevated MYB expression has been documented in adenoid cystic carcinoma (ACC), cylindroma, and spiradenoma, but the specificity of this finding is unknown. CD117 and SOX-10 expression also occurs in some cutaneous adnexal tumors. This study assesses MYB, CD117, and SOX-10 expression in cutaneous adnexal tumors. METHODS: Retrospective analysis of 184 benign adnexal tumors (140 eccrine/apocrine, 40 follicular, and 10 sebaceous), and 30 malignant adnexal tumors was performed with MYB, SOX-10, and CD117 immunostaining...
January 18, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28095327/proteomic-and-peptidomic-analysis-of-human-sweat-with-emphasis-on-proteolysis
#4
Yijing Yu, Ioannis Prassas, Carla M J Muytjens, Eleftherios P Diamandis
: Sweat is produced by eccrine and apocrine glands and represents a biological fluid with established roles in thermo-regulation and host infection defense. The composition of sweat is highly dynamic and alters significantly in various skin and other disorders. Therefore, in-depth profiling of sweat protein composition is expected to augment our understanding of the pathobiology of several skin diseases and may lead to the identification of useful sweat-based disease biomarkers. We here reported an in-depth analysis of the human sweat proteome and peptidome...
January 14, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28093664/cell-proliferation-and-differentiation-during-the-three-dimensional-reconstitution-of-eccrine-sweat-glands
#5
Xuexue Li, Haihong Li, Mingjun Zhang, Liyun Chen, Bingna Zhang
The aim of this study is to characterize the cell proliferation and proliferating cell types during three-dimensional reconstitution of eccrine sweat glands. Eccrine sweat gland cells suspended in Matrigel were injected subcutaneously into the inguinal regions of nude mice. At 1, 2, 4, 6, 8, 14, 21, 28, 35 and 42 days post-implantation, Matrigel plugs were immunostained for Ki67, to detect cycling cells, and the Ki67 labeling index at different time points was calculated. Three pairs of antibodies, Ki67/K7, Ki67/K14 and Ki67/α-SMA, were used to identify proliferating cell types in the plugs, on days 28, 35 and 42, by immunofluorescence double staining...
January 16, 2017: Journal of Molecular Histology
https://www.readbyqxmd.com/read/28093596/diagnostic-value-of-linear-fluorescence-along-the-basement-membrane-of-sweat-gland-ducts-in-bullous-pemphigoid
#6
Işın Sinem Bağcı, Orsolya N Horváth, Enno Schmidt, Thomas Ruzicka, Miklós Sárdy
Linear IgG deposits along the basement membrane of adnexa are useful in the diagnosis of bullous pemphigoid (BP), but no controlled studies have been performed. This study evaluated linear IgG fluorescence of the basement membrane of sweat gland ducts (SGD) and other adnexa in perilesional biopsies from patients with BP (n = 64) and controls (n = 82), using direct immunofluorescence microscopy. Fluorescence intensity was graded semi-quantitatively. Positive SGDs were found in 58 (90.6%) patients with BP and 44 (53...
January 17, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28079852/ichthyosiform-sarcoidosis-report-of-three-cases-from-japan-and-literature-review
#7
Takako Miura, Yasunobu Kato, Toshiyuki Yamamoto
Cutaneous lesions of sarcoidosis present with various manifestations including specific and non-specific cutaneous lesions. Ichthyosiform sarcoidosis is a rare form of cutaneous sarcoidosis, presenting with asymptomatic, adherent, polygonal scales, mainly appearing on the lower limbs.  Ichthyosiform sarcoidosis has a predilection for dark-skinned races, and cases affecting Japanese patients have rarely been reported in English literature.  We herein describe three Japanese cases of ichthyosiform sarcoidosis on the lower limbs...
December 23, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/28075427/evaluation-of-sudomotor-function-in-adult-patients-with-long-lasting-type-1-diabetes
#8
Agnieszka Gandecka, Aleksandra Araszkiewicz, Stanisław Piłaciński, Bogna Wierusz-Wysocka, Dorota Zozulińska-Ziółkiewicz
INTRODUCTION    The function of sweat glands appears to be impaired in patients with diabetic complications.  OBJECTIVES    The aim of the study was to evaluate the sudomotor function in adult patients with type 1 diabetes (DM1) and healthy controls and its relationship with metabolic control and diabetic complications. PATIENTS AND METHODS    The study included 404 adult patients with DM 1 (194 women) aged 41 years (IQR: 32-51), disease duration 23 years (IQR: 18-31). Electrochemical skin conductance (ESC) was measured with SUDOSCAN+ on feet and hands in the study group and in the control group of 84 healthy volunteers...
January 10, 2017: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/28070642/distinct-expression-profile-of-stem-cell-markers-lgr5-and-lgr6-in-basaloid-skin-tumors
#9
Bo Gun Jang, Cheol Lee, Hye Sung Kim, Myung Soo Shin, Min Seok Cheon, Jae Wang Kim, Woo Ho Kim
Mammalian epidermis, which is composed of hair follicles, sebaceous glands, and interfollicular epidermis, is maintained by discrete stem cells. In vivo lineage tracing demonstrated that murine LGR5 cells are mainly responsible for hair follicle regeneration whereas LGR6 cells generate sebaceous glands and interfollicular epidermis. However, little is known about their expression in the human skin tumors. In this study, we investigated the expression profile of LGR5 and LGR6 in a variety of human skin tumors including basaloid tumors with follicular differentiation (94 basal cell carcinomas, 18 trichoepitheliomas, 3 basaloid follicular hamartomas, and 12 pilomatricomas) and tumors with ductal differentiation (7 eccrine poromas, 8 hidradenomas, and 5 spiradenomas)...
January 9, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28045201/mutational-spectrum-of-eda-and-edar-genes-in-a-cohort-of-mexican-mestizo-patients-with-hypohidrotic-ectodermal-dysplasia
#10
Nancy Monroy-Jaramillo, José David Abad-Flores, Constanza García-Delgado, América Villaseñor-Domínguez, Carlos Mena-Cedillos, Mirna Eréndira Toledo-Bahena, Adriana María Valencia-Herrera, Adriana Sánchez-Boiso, Yumiko Imelda Akaki-Carreño, Blanca Del Río Navarro, Jesús Aguirre-Hernández, Marisol López-López, Alicia Cervantes, Marco Cerbón, Verónica Fabiola Morán-Barroso
Hypohidrotic ectodermal dysplasia (HED) has a prevalence of 1:5,000-10,000 newborns and it is characterized by hypotrichosis and abnormalities in teeth and sweat glands.(1) Most patients have an X-linked (XLHED) pattern of inheritance due to mutations in EDA which encodes for ectodysplasin. In addition, three HED-associated autosomal genes are known: EDAR which encodes for an ectodysplasin receptor; EDARADD corresponding to a cytoplasmic adaptor molecule and WNT10A which encodes for a signaling molecule of the WNT/β-catenin pathway...
January 3, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28034762/treatment-of-sweat-gland-carcinoma-with-topical-aminolevulinic-acid-photodynamic-therapy-an-effective-treatment-method-to-improve-surgical-outcomes
#11
Xian He, Yadong Yang, Yang Yang, Yuanyuan Wang, Wensheng Wang, Yanying Song, Yongfang Zen, Yunchuan Yang, Xingcun Zhang, Guoling Li, Yang Gao, Yuangang Lu
BACKGROUND: Sweat gland carcinoma is an extremely rare skin cancer, which is hard to diagnose and completely exsect without causing functional and cosmetic problems. Moreover, the high rate of recurrence is hard to handle in the treatment of sweat gland carcinoma. Photodynamic therapy is a novel treatment protocol which can selectively destroy tumor cell with good functional and cosmetic outcomes. METHODS: This is a case about a 53 years old patient with sweat gland carcinoma on his right foot, which received surgery and photodynamic therapy...
December 26, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28027826/clinicopathologic-analysis-of-atypical-hand-foot-and-mouth-disease-in-adult-patients
#12
Julie Second, Charles Velter, Sophie Calès, François Truchetet, Dan Lipsker, Bernard Cribier
BACKGROUND: Hand, foot, and mouth disease is a contagious viral infection usually affecting children. A resurgence of cases in adults, mainly caused by coxsackievirus A6 and with an atypical and more severe presentation, has taken place. OBJECTIVE: The goal was to examine the clinical, histologic, and immunohistochemical features of this disease in adults. METHODS: This is a retrospective study on documented cases of adult hand, foot, and mouth disease from France's Dermatology Department of Strasbourg University Hospital and Bel-Air Hospital in Thionville...
December 24, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28027799/regulation-of-epithelial-ion-transport-in-exocrine-glands-by-store-operated-ca-2-entry
#13
REVIEW
Axel R Concepcion, Stefan Feske
Store-operated Ca(2+) entry (SOCE) is a conserved mechanism of Ca(2+) influx that regulates Ca(2+) signaling in many cell types. SOCE is activated by depletion of endoplasmic reticulum (ER) Ca(2+) stores in response to physiological agonist stimulation. After it was first postulated by J.W. Putney Jr. in 1986, SOCE has been described in a large number of non-excitable cell types including secretory cells of different exocrine glands. Here we discuss the mechanisms by which SOCE controls salt and fluid secretion in exocrine glands, with a special focus on eccrine sweat glands...
December 21, 2016: Cell Calcium
https://www.readbyqxmd.com/read/28010819/transition-duration-of-ingested-deuterium-oxide-to-eccrine-sweat-during-exercise-in-the-heat
#14
Adam Church, Fanny Lee, Michael J Buono
The time necessary for the initial appearance of ingested water as sweat during exercise in the heat remains unknown. Based on the current literature, we estimated fluid transition through the body, from ingestion to appearance as sweat, to have a minimum time duration of approximately three minutes. The purpose of this study was to test this prediction and identify the time necessary for the initial enrichment of deuterium oxide (D2O) in sweat following ingestion during exercise in the heat. Eight participants performed moderate intensity (40% of maximal oxygen uptake) treadmill exercise in an environmental chamber (40°C, 40% rH) to induce active sweating...
January 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28008606/derivation-of-marker-gene-signatures-from-human-skin-and-their-use-in-the-interpretation-trancriptional-changes-associated-with-dermatological-disorders
#15
Barbara Bo-Ju Shih, Ajit Johnson Nirmal, Denis John Headon, Arne Nalpon Akbar, Neil Andrew Mabbott, Tom Charles Freeman
Numerous studies have explored the altered transcriptional landscape associated with skin diseases to understand the nature of these disorders. However, data interpretation represents a significant challenge due to a lack of good maker sets for many of the specialised cell types that make up this tissue, whose composition may fundamentally alter during disease. Here we have sought to derive expression signatures that define the various cell types and structures that make up human skin, and demonstrate how they can be used to aid the interpretation of transcriptomic data derived from this organ...
December 23, 2016: Journal of Pathology
https://www.readbyqxmd.com/read/28008050/how-to-grow-hair-or-sweat-glands
#16
EDITORIAL
Laura M Zahn
No abstract text is available yet for this article.
December 23, 2016: Science
https://www.readbyqxmd.com/read/28008008/spatiotemporal-antagonism-in-mesenchymal-epithelial-signaling-in-sweat-versus-hair-fate-decision
#17
Catherine P Lu, Lisa Polak, Brice E Keyes, Elaine Fuchs
The gain of eccrine sweat glands in hairy body skin has empowered humans to run marathons and tolerate temperature extremes. Epithelial-mesenchymal cross-talk is integral to the diverse patterning of skin appendages, but the molecular events underlying their specification remain largely unknown. Using genome-wide analyses and functional studies, we show that sweat glands are specified by mesenchymal-derived bone morphogenetic proteins (BMPs) and fibroblast growth factors that signal to epithelial buds and suppress epithelial-derived sonic hedgehog (SHH) production...
December 23, 2016: Science
https://www.readbyqxmd.com/read/27990394/great-saphenous-vein-dilatation-with-reflux-at-the-saphenofemoral-junction-a-rare-underlying-association-of-eccrine-angiomatous-hamartoma
#18
Sanjiv Choudhary, Quazi Sabiha, Adarsh Lata Singh
Eccrine angiomatous hamartoma (EAH) is an exceedingly rare benign tumor-like lesion prevalent in childhood, which can produce pain and marked sweating. Histological features include proliferation of eccrine sweat glands and angiomatous capillary channels. It may be rarely associated with underlying pathological conditions. A 15-year-old female patient presented with multiple tender reddish papules and nodules coalescing to form plaques of 10 × 8 cm over the anterior aspect of the right lower thigh since birth...
November 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27981794/reproductive-tract-histology-in-south-american-fur-seal-pups-arctophoca-australis
#19
Helena Katz, Olle Johansson
In the present study, a detailed histological description of the female reproductive tract of South American fur seal (Arctophoca australis) pups has been conducted. The uterine tube was covered by cuboidal to columnar epithelium; nerve fibers were present in the mesosalpinx and beneath the muscular layer. The uterus was bipartitus; the endometrial surface of the horns was lined by a simple cuboidal or columnar epithelium with deep tubular glands; caudally ("the transition area"), the epithelium changed to pseudostratified columnar, few tubular glands were present and the myometrium increased in width...
December 16, 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/27981668/activation-of-protease-activated-receptor-2-mediates-cutaneous-vasodilatation-but-not-sweating-roles-of-nitric-oxide-synthase-and-cyclooxygenase
#20
Naoto Fujii, Brendan D McNeely, Sarah Y Zhang, Yasmine C Abdellaoui, Mercy O Danquah, Glen P Kenny
Protease-activated receptor 2 (PAR2) is present in human skin including keratinocytes, endothelial cells of skin microvessels, and eccrine sweat glands. However, whether PAR2 functionally contributes to the regulation of cutaneous blood flow and sweating remains entirely unclear in humans in vivo. We hypothesized that activation of PAR2 directly stimulates cutaneous vasodilatation and sweating via actions of nitric oxide synthase (NOS) and cyclooxygenase (COX). In twelve physically active young males (29 ± 5 years), cutaneous vascular conductance (CVC) and sweat rate were measured at four intradermal microdialysis forearm skin sites that were treated with 1) lactated Ringer's solution (Control), 2) 10 mm N(ω) -nitro-L -arginine (NOS inhibitor), 3) 10 mm ketorolac (COX inhibitor), or 4) a combination of both inhibitors...
December 16, 2016: Experimental Physiology
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