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https://www.readbyqxmd.com/read/28802502/cutaneous-sweat-gland-carcinomas-with-basaloid-differentiation-an-update-with-emphasis-on-differential-diagnoses
#1
REVIEW
Katharina Flux, Thomas Brenn
This article focuses on primary cutaneous sweat gland carcinomas with basaloid differentiation, including cribriform apocrine carcinoma, endocrine mucin-producing sweat gland carcinoma, mucinous carcinoma, adenoid cystic carcinoma, spiradenocarcinoma, and digital papillary adenocarcinoma. These tumors are rare and pose a significant diagnostic challenge. Their clinical presentation is nonspecific and there is significant overlap of their histologic features. Confident diagnosis is necessary because their clinical behavior ranges from indolent, nonrecurring, nonmetastasizing tumors to those with potential for disseminated disease and mortality...
September 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28796813/a-novel-organotypic-3d-sweat-gland-model-with-physiological-functionality
#2
Patricia Klaka, Sabine Grüdl, Bernhard Banowski, Melanie Giesen, Andrea Sättler, Peter Proksch, Thomas Welss, Thomas Förster
Dysregulated human eccrine sweat glands can negatively impact the quality-of-life of people suffering from disorders like hyperhidrosis. Inability of sweating can even result in serious health effects in humans affected by anhidrosis. The underlying mechanisms must be elucidated and a reliable in vitro test system for drug screening must be developed. Here we describe a novel organotypic three-dimensional (3D) sweat gland model made of primary human eccrine sweat gland cells. Initial experiments revealed that eccrine sweat gland cells in a two-dimensional (2D) culture lose typical physiological markers...
2017: PloS One
https://www.readbyqxmd.com/read/28794552/histopathological-analysis-of-skin-adnexal-tumors-a-three-year-study-of-110-cases-at-a-tertiary-care-center
#3
Kanwalpreet Kaur, Karuna Gupta, Deepika Hemrajani, Ajay Yadav, Kalpana Mangal
BACKGROUND: Skin adnexal tumors (SAT) encompass wide spectrum of benign and malignant tumors that differentiate toward one or more adnexal structures found in normal skin. Overall incidence of SATs is low yet they can be challenging to diagnose. AIMS: The aim of this study is to study the spectrum and microscopic features of SATs. MATERIALS AND METHODS: It was a retrospective cross-sectional, descriptive study conducted over a period of 3 years...
July 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28781903/diagnostic-workup-and-treatment-of-a-rare-apocrine-hidrocystoma-affecting-the-oral-mucosa-a-clinical-and-histological-case-report
#4
Pier Paolo Poli, Luca Creminelli, Valeria Moramarco, Alessandro Del Gobbo, Franco Ferrante, Carlo Maiorana
Apocrine hidrocystomas are rare benign cystic tumors originating from the secretory portion of apocrine sweat glands. To the best of our knowledge, there is no evidence currently available reporting the presence of apocrine hidrocystomas in the oral cavity. Therefore, this case report aims to describe the clinical and histological features of an apocrine hidrocystoma affecting the oral mucosa. A 69-year-old male patient presented with a 1-year history of a solitary, well-circumscribed, submucosal mass in the left posterior buccal mucosa...
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/28765669/application-to-skin-physiology-using-optical-coherence-tomography
#5
Masato Ohmi
Background and aims: The sweat glands and peripheral vessels beneath the skin surface act as minute organs governed by the skin sympathetic nerves and have important physiological functions for body temperature control and nutrition support along with maintenance of a peripheral organization. Dynamics of the mental sweating of sweat glands and the peripheral vessels reflect the activity of a sympathetic nerve. The purpose of this paper is to study the dynamic observation and analysis of sweat glands and a peripheral vessels by optical coherence tomography (OCT)...
December 30, 2016: Laser Therapy
https://www.readbyqxmd.com/read/28759701/pharmacological-interventions-for-preventing-dry-mouth-and-salivary-gland-dysfunction-following-radiotherapy
#6
REVIEW
Philip Riley, Anne-Marie Glenny, Fang Hua, Helen V Worthington
BACKGROUND: Salivary gland dysfunction is an 'umbrella' term for the presence of either xerostomia (subjective sensation of dryness), or salivary gland hypofunction (reduction in saliva production). It is a predictable side effect of radiotherapy to the head and neck region, and is associated with a significant impairment of quality of life. A wide range of pharmacological interventions, with varying mechanisms of action, have been used for the prevention of radiation-induced salivary gland dysfunction...
July 31, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28754083/associations-between-ectodermal-dysplasia-psychological-distress-and-quality-of-life-in-a-group-of-adults-with-oligodontia
#7
Solfrid Sørgjerd Saltnes, Janicke Liaaen Jensen, Rønnaug Sæves, Hilde Nordgarden, Amy Østertun Geirdal
OBJECTIVE: The aim of this study was to assess demographics, self-reported signs of ectodermal dysplasia (problems with hair, nails, skin and sweat glands), present teeth, previous dental treatment, psychological distress and QoL in individuals with oligodontia, and to explore the associations between these factors. We also aimed to compare the level of psychological distress and QoL between the study group and normative samples. METHODS: Forty-seven individuals with oligodontia registered at a resource centre in Norway were included in the study...
July 28, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28748670/whole-genome-detection-of-signature-of-positive-selection-in-african-cattle-reveals-selection-for-thermotolerance
#8
Mengistie Taye, Wonseok Lee, Kelsey Caetano-Anolles, Tadelle Dessie, Olivier Hanotte, Okeyo Ally Mwai, Stephen Kemp, Seoae Cho, Sung Jong Oh, Hak-Kyo Lee, Heebal Kim
As African indigenous cattle evolved in a hot tropical climate, they have developed an inherent thermotolerance; survival mechanisms include a light-colored and shiny coat, increased sweating, and cellular and molecular mechanisms to cope with high environmental temperature. Here, we report the positive selection signature of genes in African cattle breeds which contribute for their heat tolerance mechanisms. We compared the genomes of five indigenous African cattle breeds with the genomes of four commercial cattle breeds using cross-population composite likelihood ratio (XP-CLR) and cross-population extended haplotype homozygosity (XP-EHH) statistical methods...
July 27, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28747449/loss-of-cutaneous-large-and-small-fibers-in-naive-and-l-dopa-treated-pd-patients
#9
Maria Nolano, Vincenzo Provitera, Fiore Manganelli, Rosa Iodice, Annamaria Stancanelli, Giuseppe Caporaso, Annamaria Saltalamacchia, Francesca Califano, Bernardo Lanzillo, Marina Picillo, Paolo Barone, Lucio Santoro
OBJECTIVE: To study small and large fiber pathology in drug-naive and l-dopa-treated patients affected by Parkinson disease (PD) in early phases, before the occurrence of neuropathic electrophysiologic abnormalities. METHODS: We enrolled 85 patients with idiopathic PD (male/female 49/36, age 61.3 ± 9.7 years) without electrophysiologic signs of neuropathy, including 48 participants naive to l-dopa treatment. All patients underwent clinical, functional, and morphologic assessment of sensory and autonomic nerves through dedicated questionnaires, quantitative sensory testing, sympathetic skin response, dynamic sweat test, and punch biopsies from glabrous and hairy skin...
July 26, 2017: Neurology
https://www.readbyqxmd.com/read/28736232/stage-specific-embryonic-antigen-4-ssea-4-as-a-distinguishing-marker-between-eccrine-and-apocrine-origin-of-ducts-of-sweat-glands
#10
Julia Borowczyk-Michalowska, Eliza Zimolag, Piotr Konieczny, Anna Chrapusta, Zbigniew Madeja, Justyna Drukala
No abstract text is available yet for this article.
July 20, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28732801/bicarbonate-in-cystic-fibrosis
#11
REVIEW
Karl Kunzelmann, Rainer Schreiber, Hans Beat Hadorn
BACKGROUND: Cystic fibrosis (CF, mucoviscidosis) is caused by mutations in the gene encoding CF transmembrane conductance regulator (CFTR), which is a chloride and bicarbonate channel necessary for fluid secretion and extracellular alkalization. For a long time, research concentrated on abnormal Cl(-) and Na(+) transport, but neglected bicarbonate as a crucial factor in CF. METHODS: The present short review reports early findings as well as recent insights into the role of CFTR for bicarbonate transport and its defects in CF...
July 18, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/28730221/usefulness-of-ultrastructure-studies-for-the-estimation-of-the-postmortem-interval-a-systematic-review
#12
Sorin Hostiuc, Mugurel Constantin Rusu, Vasile Sorin Mănoiu, Alexandra Diana Vrapciu, IonuŢ Negoi, Maria Viorela Popescu
Establishing the postmortem interval (PMI) is vital in legal medicine as it allows to retrospectively estimate the hour of death, which is essential for the police as a starting point for their inquiries (especially in violent deaths). Ultrastructure studies aimed specifically to detect autolytic changes are scarcely identified in the scientific literature. Moreover, they are performed in a variety of conditions (different temperatures, species, in vitro ÷ in situ, and so on), making the results difficult to interpret for legal medicine purposes...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28722532/bi-institutional-retrospective-study-on-the-demographics-and-basic-clinical-presentation-of-hidrocystomas
#13
Michelle Maeng, Paul Petrakos, Mei Zhou, Benjamin Levine, Gary Lelli, Pete Setabutr
Hidrocystomas are benign, cystic lesions of eccrine and apocrine sweat glands. The literature on hidrocystomas is sparse, consisting of a handful of case reports and limited retrospective reviews. This is the first known bi-institutional, retrospective, chart review aimed to elucidate the demographics and basic clinical presentation of hidrocystomas. Medical records of adult patients with a pathological diagnosis of hidrocystoma from September 1, 2008 to August 1, 2015 in the Oculoplastic and Reconstructive Surgery Service at the Illinois Eye and Ear Infirmary (UIC) and Department of Ophthalmology of Weill Cornell Medical College (Cornell) were reviewed...
July 19, 2017: Orbit
https://www.readbyqxmd.com/read/28721214/porocarcinoma-presentation-and-management-a-meta-analysis-of-453-cases
#14
REVIEW
Abdulwahid M Salih, F H Kakamad, Hiwa O Baba, Rawezh Q Salih, M R Hawbash, Shvan H Mohammed, Snur Othman, Yadgar A Saeed, Imad J Habibullah, Aso S Muhialdeen, Rebaz O Nawroly, Zuhair D Hammood, Nawshirwan H Abdulkarim
BACKGROUND: porocarcinoma is a rare sort of skin cancer developing from sweat glands. Its clinical course and management are not well understood. OBJECTIVES: the current meta-analysis is to address the presentation and management of porocarcinoma. DATA SOURCES: Web of Science, PubMed, MEDLINE on OVID and Google scholar were searched for English-language studies published before December 1, 2016. RESULTS: The review of literature revealed 453 cases...
August 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28717319/changes-in-histopathology-and-cytokeratin-ae1-ae3-expression-in-skin-graft-with-different-time-on-indonesian-local-cats
#15
Erwin, Etriwati, Gunanti, Ekowati Handharyani, Deni Noviana
AIM: A good skin graft histopathology is followed by formation of hair follicle, sweat gland, sebaceous gland, blood vessel, lightly dense connective tissue, epidermis, and dermis layer. This research aimed to observe histopathology feature and cytokeratin AE1/AE3 expression on cat skin post skin grafting within a different period of time. MATERIALS AND METHODS: Nine male Indonesian local cats aged 1-2 years old weighing 3-4 kg were separated into three groups. First surgery created defect wound of 2 cm × 2 cm in size to whole groups...
June 2017: Veterinary World
https://www.readbyqxmd.com/read/28714085/neural-control-of-sweat-secretion-a-review
#16
REVIEW
Y Hu, C Converse, M C Lyons, W H Hsu
Humans have 4 million exocrine sweat glands, which can be classified into two types: eccrine and apocrine glands. Sweat secretion is a constitutive feature, which is directly involved in thermoregulation and metabolism. Sweat secretion is regulated by both the central nervous system(1) and autonomic nervous system.(2) In peripheral areas, the ANS, especially the sympathetic nervous system (SNS), mediates the transmission of neurotransmitters to sweat glands. Two principal chemical mediators, acetylcholine and noradrenaline (NA)/adrenaline (ADR), are released by the SNS, which stimulate sweat secretion...
July 17, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28692463/syringotropic-mycosis-fungoides-a-rare-form-of-cutaneous-t-cell-lymphoma-enabling-a-histopathologic-sigh-of-relief
#17
Larisa M Lehmer, Kyle T Amber, Sébastien M de Feraudy
Syringotropic mycosis fungoides (STMF) is a very rare variant of cutaneous T-cell lymphoma. It follows a much milder disease course than its clinically indistinguishable adnexal counterpart, folliculotropic mycosis fungoides (FMF). We report a case of a 36-year-old man who presented with erythematous, studded papules and plaques on the left upper extremity and right anterior thigh diagnosed as mycosis fungoides (MF) Stage 1A on initial superficial shave biopsy. Lesions recurred after initial improvement with narrow-band ultraviolet light therapy demonstrating a concentration of abnormal lymphocytes around eccrine sweat glands on repeat biopsy consistent with STMF...
May 18, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28689642/cells-in-3d-reconstitutued-eccrine-sweat-gland-cell-spheroids-differentiate-into-gross-cystic-disease-fluid-protein-15-expressing-dark-secretory-cells-and-carbonic-anhydrase-ii-expressing-clear-secretory-cells
#18
Haihong Li, Liyun Chen, Mingjun Zhang, Bingna Zhang
Secretory coils of eccrine sweat glands are composed of myoepithelial cells, dark secretory cells and clear secretory cells. The two types of cells play important roles in sweat secretion. In our previous study, we demonstrated that the 3D-reconstituted eccrine sweat gland cell spheroids differentiate into secretory coil-like structures. However, whether the secretory coil-like structures further differentiate into dark secretory cells and clear secretory cells were is still unknown. In this study, we detected the differentiation of clear and dark secretory cells in the 3D-reconstituted eccrine sweat gland cell spheroids using the dark secretory cell-specific marker, GCDFP-15, and clear secretory cell-specific marker, CAII by immunofluorescence staining...
July 6, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28686597/altered-paracellular-cation-permeability-due-to-a-rare-cldn10b-variant-causes-anhidrosis-and-kidney-damage
#19
Joakim Klar, Jörg Piontek, Susanne Milatz, Muhammad Tariq, Muhammad Jameel, Tilman Breiderhoff, Jens Schuster, Ambrin Fatima, Maria Asif, Muhammad Sher, Katrin Mäbert, Anja Fromm, Shahid M Baig, Dorothee Günzel, Niklas Dahl
Claudins constitute the major component of tight junctions and regulate paracellular permeability of epithelia. Claudin-10 occurs in two major isoforms that form paracellular channels with ion selectivity. We report on two families segregating an autosomal recessive disorder characterized by generalized anhidrosis, severe heat intolerance and mild kidney failure. All affected individuals carry a rare homozygous missense mutation c.144C>G, p.(N48K) specific for the claudin-10b isoform. Immunostaining of sweat glands from patients suggested that the disease is associated with reduced levels of claudin-10b in the plasma membranes and in canaliculi of the secretory portion...
July 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28686209/detailed-characterization-of-sympathetic-chain-ganglia-schg-neurons-supplying-the-skin-of-the-porcine-hindlimb
#20
Anna Kozłowska, Anita Mikołajczyk, Mariusz Majewski
It is generally known that in the skin sympathetic fibers innervate various dermal structures, including sweat glands, blood vessels, arrectores pilorum muscles and hair follicles. However, there is a lack of data about the distribution and chemical phenotyping of the sympathetic chain ganglia (SChG) neurons projecting to the skin of the pig, a model that is physiologically and anatomically very representative for humans. Thus, the present study was designed to establish the origin of the sympathetic fibers supplying the porcine skin of the hind leg, and the pattern(s) of putative co-incidence of dopamine-β-hydroxylase (DβH) with pituitary adenylate cyclase-activating polypeptide (PACAP), somatostatin (SOM), neuronal nitric oxide synthase, substance P, vasoactive intestinal peptide, neuropeptide Y (NPY), leu5-enkephalin and galanin (GAL) using combined retrograde tracing and double-labeling immunohistochemistry...
July 7, 2017: International Journal of Molecular Sciences
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