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https://www.readbyqxmd.com/read/29222786/nerve-growth-factor-induced-angiogenesis-1-endothelial-cell-tube-formation-assay
#1
Philip Lazarovici, Adi Lahiani, Galit Gincberg, Dikla Haham, Arnon Fluksman, Ofra Benny, Cezary Marcinkiewicz, Peter I Lelkes
Nerve growth factor (NGF) is a neurotrophin promoting survival, proliferation, differentiation, and neuroprotection in the embryonal and adult nervous system. NGF also induces angiogenic effects in the cardiovascular system, which may be beneficial in engineering new blood vessels and for developing novel anti-angiogenesis therapies for cancer. Angiogenesis is a cellular process characterized by a number of events, including endothelial cell migration, invasion, and assembly into capillaries. In vitro endothelial tube formation assays are performed using primary human umbilical vein endothelial cells, human aortic endothelial cells, and other human or rodent primary endothelial cells isolated from the vasculature of both tumors and normal tissues...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29222540/validation-study-of-the-american-joint-committee-on-cancer-eighth-edition-prognostic-stage-compared-with-the-anatomic-stage-in-breast-cancer
#2
Anna Weiss, Mariana Chavez-MacGregor, Daphne Y Lichtensztajn, Min Yi, Audree Tadros, Gabriel N Hortobagyi, Sharon H Giordano, Kelly K Hunt, Elizabeth A Mittendorf
Importance: The American Joint Committee on Cancer (AJCC) eighth edition staging manual introduced a new prognostic stage for breast cancer incorporating biologic factors in addition to traditional anatomic factors. Objective: To perform a validation study of the AJCC eighth edition prognostic stage in a single-institution cohort and a large population database. Design, Setting, and Participants: Patients with breast cancer treated with surgery as an initial intervention were identified in a prospective institutional database from The University of Texas MD Anderson Cancer Center and the California Cancer Registry...
December 7, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29222080/the-12-item-self-report-world-health-organization-disability-assessment-schedule-whodas-2-0-administered-via-the-internet-to-individuals-with-anxiety-and-stress-disorders-a-psychometric-investigation-based-on-data-from-two-clinical-trials
#3
Erland Axelsson, Elin Lindsäter, Brjánn Ljótsson, Erik Andersson, Erik Hedman-Lagerlöf
BACKGROUND: The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) is a widespread measure of disability and functional impairment, which is bundled with the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) for use in psychiatry. Administering psychometric scales via the Internet is an effective way to reach respondents and allow for convenient handling of data. OBJECTIVE: The aim was to study the psychometric properties of the 12-item self-report WHODAS 2...
December 8, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/29217105/influence-of-muscle-strength-on-early-mobility-in-critically-ill-adult-patients-systematic-literature-review
#4
REVIEW
Audrey R Roberson, Angela Starkweather, Catherine Grossman, Edmund Acevedo, Jeanne Salyer
BACKGROUND: Muscle strength may be one indicator of readiness to mobilize that can be used to guide decisions regarding early mobility efforts and to progressively advance mobilization. OBJECTIVES: To provide a synthesis of current measures of muscle strength in the assessment of early mobilization in critically ill adult patients who are receiving MV therapy. METHODS: Research studies conducted between 2000-2015 were identified using PubMed, CINHAL, MEDLINE, and the Cochrane Database of Systematic Reviews databases using the search terms "muscle strength", "intensive care", "mechanical ventilation" and "muscle weakness"...
January 2018: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/29214466/large-scale-dna-organization-is-a-prognostic-marker-of-breast-cancer-survival
#5
Martial Guillaud, Qian Ye, Sam Leung, Anita Carraro, Alan Harrison, Malcolm Hayes, Alan Nichol, Mira Keyes
Breast cancer is the leading cause of cancer-related deaths among women worldwide. We investigated whether changes in large-scale DNA organization (LDO) of tumor epithelial nuclei are an indicator of the aggressiveness of the tumor. We tested our algorithm on a set of 172 duplicates TMA cores samples coming from 95 breast cancer patients. Thirty-five patients died of breast cancer, and 60 were still alive 10 years after surgery. Duplicates cores were used to create training and test set. The TMA slides were stained with Feulgen-thionin and imaged using our in-house high-resolution Imaging system...
December 6, 2017: Medical Oncology
https://www.readbyqxmd.com/read/29207834/clinical-evaluation-of-quality-of-obturation-and-instrumentation-time-using-two-modified-rotary-file-systems-with-manual-instrumentation-in-primary-teeth
#6
Lavanya Govindaraju, Ganesh Jeevanandan, Emg Subramanian
Introduction: Pulp therapy in primary teeth has been performed using various instrumentation techniques. However, the conventional instrumentation technique used for root canal preparation in primary teeth is hand instrumentation. Various Nickel-Titanium (Ni-Ti) instruments are available to perform efficient root canal preparation in primary teeth. These Ni-Ti instruments has been designed to aid in better root canal preparation in permanent teeth but are rarely used in primary teeth...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29204011/effect-of-scapular-stabilization-exercise-during-standing-on-upper-limb-function-and-gait-ability-of-stroke-patients
#7
J O Kim, J Lee, B H Lee
Background: The purpose of this study was to determine the effect of scapular stabilization exercise during standing on a paretic side on upper limb function and gait ability of stroke patients. Methods: This study was a hospital-based, randomized controlled trial with a blinded assessor. A total of 17 patients with hemiplegic diagnosis after stroke were divided into two groups (9 patients in a study group and 8 patients in a control group). The study group received physical therapy and scapular stabilization exercise on a paretic side...
October 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29203173/evaluation-of-the-dynamic-predictors-of-fluid-responsiveness-in-dogs-receiving-goal-directed-fluid-therapy
#8
Maja J Drozdzynska, Yu-Mei Chang, Giacomo Stanzani, Ludovic Pelligand
OBJECTIVES: Goal-directed fluid therapy (GDFT) based on pulse pressure variation (PPV) was used in anaesthetized dogs undergoing abdominal surgeries. The aims were 1) to evaluate the success rate of the PPV ≥13% in detecting fluid responsiveness [delta stroke volume (ΔSV) ≥10%]; 2) to assess the correlation between PPV, systolic pressure variation (SPV), Plethysmograph Variability Index (PVI) and central venous pressure (CVP) and 3) to establish the threshold value for the PVI that would predict a PPV value of ≥13% and indirectly discriminate responders from nonresponders to fluid therapy...
June 17, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29203046/-post-traumatic-carotido-jugular-fistula-case-report-and-review-of-the-literature
#9
A Dammak, H Ben Jmaà, S Hadhri, H Cheikhrouhou, F Dhouib, S Haddar, L Kammoun, T Ben Jmaà, B Hammami, S Masmoudi, N Elleuch, M Ben Jmaà, I Frikha
The neck, being not protected by skeleton, is vulnerable to external trauma and injury which can involve blood vessels, muscles, nerves, and trachea. Carotid injuries can be potentially life-threatening by hemorrhage and stroke. We present a case of a 26-year-old manual worker who presented a neck injury caused by a metallic projectile. The injury involved the right common carotid artery with an internal jugular vein fistula, and tracheal damage. The patient was managed with surgical repair of the tracheal lesion, reconstruction of the carotid section using a PTFE graft bypass, and ligation of the internal jugular vein...
December 2017: Journal de Médecine Vasculaire
https://www.readbyqxmd.com/read/29202957/parental-influences-on-sperm-banking-attempts-among-adolescent-males-newly-diagnosed-with-cancer
#10
James L Klosky, Jessica S Flynn, Vicky Lehmann, Kathryn M Russell, Fang Wang, Robin N Hardin, Jasmine R Eddinger, Hui Zhang, Lauren A-M Schenck, Leslie R Schover
OBJECTIVE: To investigate the influence of parental sociodemographic, communication, and psychological factors on sperm collection attempts among at-risk adolescent males newly diagnosed with cancer. DESIGN: Prospective, single group, observational study design. SETTING: Pediatric oncology centers. PATIENT(S): Parents (N = 144) of 122 newly diagnosed adolescent males at increased risk for infertility secondary to cancer therapy...
December 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/29202816/the-treatment-of-migraine-patients-within-chiropractic-analysis-of-a-nationally-representative-survey-of-1869-chiropractors
#11
Craig Moore, Jon Adams, Andrew Leaver, Romy Lauche, David Sibbritt
BACKGROUND: While the clinical role of manual therapies in migraine management is unclear, the use of chiropractors for this condition is considerable. The aim of this study is to evaluate the prevalence and characteristics of chiropractors who frequently manage patients with migraine. METHODS: A national cross-sectional survey of chiropractors collected information on practitioner characteristics, clinical management characteristics and practice settings. A secondary analysis was conducted on 1869 respondents who reported on their migraine caseload to determine the predictors associated with the frequent management of patients with migraine...
December 4, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29202668/quality-of-life-and-care-needs-in-women-with-estrogen-positive-metastatic-breast-cancer-a-qualitative-study
#12
Gitte Lee Mortensen, Ivan Bredbjerg Madsen, Randi Krogsgaard, Bent Ejlertsen
BACKGROUND: In recent years, the prognosis of metastatic breast cancer (MBC) has improved with more effective therapies applicable to a wider range of patients. To many patients, a MBC diagnosis thus initiates a prolonged course of illness and treatment. This qualitative study aimed to explore the long-term health-related quality of life (HRQoL) and support needs in MBC patients of all ages in the Danish context. MATERIAL AND METHODS: Eighteen MBC patients participated in five qualitative focus group interviews that were analyzed using content analysis and a constructivist approach...
December 5, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29200833/positive-airway-pressure-adherence-and-subthreshold-adherence-in-posttraumatic-stress-disorder-patients-with-comorbid-sleep-apnea
#13
Barry J Krakow, Jessica J Obando, Victor A Ulibarri, Natalia D McIver
Study objectives: Patients with comorbid posttraumatic stress disorder (PTSD) and obstructive sleep apnea (OSA) manifest low adherence to continuous positive airway pressure (CPAP) due to fixed, pressure-induced expiratory pressure intolerance (EPI), a subjective symptom and objective sign aggravated by anxiety sensitivity and somatosensory amplification. As advanced PAP therapy modes (ie, auto-bilevel PAP [ABPAP] or adaptive servo-ventilation [ASV]) may address these side effects, we hypothesized such treatment would be associated with decreased expiratory intolerance and increased adherence in posttraumatic stress patients with co-occurring OSA...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29199692/anaplastic-lymphoma-kinase-immunohistochemistry-in-lung-adenocarcinomas-evaluation-of-performance-of-standard-manual-method-using-d5f3-antibody
#14
D Jain, K Jangra, P S Malik, S Arulselvi, K Madan, S Mathur, M C Sharma
OBJECTIVE: Immunohistochemistry (IHC) with anaplastic lymphoma kinase (ALK) antibodies is considered as an economical screening method in lung adenocarcinomas. Automated Ventana D5F3-IHC is approved by US Food and Drug Administration for targeted therapy; however, the automated IHC apparatus are not widely used in most laboratories. We evaluated the performance of ALK IHC using the manual semiquantitative method to assess the concordance with Ventana ALK IHC assay. MATERIALS AND METHODS: We tested 156 cases of primary lung adenocarcinomas for ALK protein expression by D5F3-IHC...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29198341/concomitant-use-of-corticosteroids-and-immune-checkpoint-inhibitors-in-patients-with-hematologic-or-solid-neoplasms-a-systematic-review
#15
REVIEW
A Garant, C Guilbault, T Ekmekjian, Z Greenwald, P Murgoi, T Vuong
PURPOSE: Clinical trials studying immune checkpoint inhibitors exclude patients on corticosteroids, due to the hypothesis that corticosteroids may antagonize immunotherapy. We performed a systematic review of the literature looking at the clinical outcomes of cancer patients treated with immune checkpoint inhibitors and concomitant corticosteroids. METHODS: The following databases were searched for relevant studies: MEDLINE, Embase Classic+Embase, BIOSIS Previews, the Cochrane Database of Systematic Reviews, the CENTRAL Registry of Controlled Trials, Web of Science and Scopus...
December 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29197180/acupuncture-for-neuropathic-pain-in-adults
#16
REVIEW
Zi Yong Ju, Ke Wang, Hua Shun Cui, Yibo Yao, Shi Min Liu, Jia Zhou, Tong Yu Chen, Jun Xia
BACKGROUND: Neuropathic pain may be caused by nerve damage, and is often followed by changes to the central nervous system. Uncertainty remains regarding the effectiveness and safety of acupuncture treatments for neuropathic pain, despite a number of clinical trials being undertaken. OBJECTIVES: To assess the analgesic efficacy and adverse events of acupuncture treatments for chronic neuropathic pain in adults. SEARCH METHODS: We searched CENTRAL, MEDLINE, Embase, four Chinese databases, ClinicalTrials...
December 2, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29197129/patient-self-care-of-periodontal-pocket-infections
#17
REVIEW
Nicole Birgit Arweiler, Thorsten M Auschill, Anton Sculean
Treatment of periodontitis aims to control the infection caused by the periodontal pathogenic flora and includes mechanical debridement of root surfaces to disrupt the supragingival and subgingival biofilm. As periodontal pockets of ≤ 5 mm can be perform in a stable condition and may not need additional therapy, the ability and the willingness of the patient to perform good oral hygiene on a long-term basis are of utmost importance for ensuring long-term success of periodontal treatment. In this context, the aim of all home-care measures must be the optimal control of plaque biofilm in order to prevent or treat gingival inflammation as a primary stage of periodontitis...
December 1, 2017: Periodontology 2000
https://www.readbyqxmd.com/read/29193781/impact-of-tumour-motion-compensation-and-delineation-methods-on-fdg-pet-based-dose-painting-plan-quality-for-nsclc-radiation-therapy
#18
Hannah Mary Thomas, Paul E Kinahan, James Jebaseelan E Samuel, Stephen R Bowen
INTRODUCTION: To quantitatively estimate the impact of different methods for both boost volume delineation and respiratory motion compensation of [18F] FDG PET/CT images on the fidelity of planned non-uniform 'dose painting' plans to the prescribed boost dose distribution. METHODS: Six locally advanced non-small cell lung cancer (NSCLC) patients were retrospectively reviewed. To assess the impact of respiratory motion, time-averaged (3D AVG), respiratory phase-gated (4D GATED) and motion-encompassing (4D MIP) PET images were used...
November 28, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29192305/association-of-quantitative-metastatic-lymph-node-burden-with-survival-in-hypopharyngeal-and-laryngeal-cancer
#19
Allen S Ho, Sungjin Kim, Mourad Tighiouart, Cynthia Gudino, Alain Mita, Kevin S Scher, Anna Laury, Ravi Prasad, Stephen L Shiao, Nabilah Ali, Chrysanta Patio, Jon Mallen-St Clair, Jennifer E Van Eyk, Zachary S Zumsteg
Importance: Nodal staging for laryngohypopharyngeal cancers is based primarily on size and laterality, with less value placed on absolute number of metastatic lymph nodes (LNs). We are aware of no studies to date that have specifically addressed the prognostic effect of quantitative nodal burden in larynx or hypopharynx malignancies. Objective: To assess the independent impact of quantitative metastatic LN burden on mortality risk. Design, Setting, and Participants: Univariate and multivariable models were constructed to evaluate the association between patients' number of metastatic LNs and their survival, adjusting for factors such as nodal size, laterality, extranodal extension, margin status, and adjuvant treatment...
November 30, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29191232/active-versus-passive-adverse-event-reporting-after-pediatric-chiropractic-manual-therapy-study-protocol-for-a-cluster-randomized-controlled-trial
#20
Katherine A Pohlman, Linda Carroll, Ross T Tsuyuki, Lisa Hartling, Sunita Vohra
BACKGROUND: Patient safety performance can be assessed with several systems, including passive and active surveillance. Passive surveillance systems provide opportunity for health care personnel to confidentially and voluntarily report incidents, including adverse events, occurring in their work environment. Active surveillance systems systematically monitor patient encounters to seek detailed information about adverse events that occur in work environments; unlike passive surveillance, active surveillance allows for collection of both numerator (number of adverse events) and denominator (number of patients seen) data...
December 1, 2017: Trials
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