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Musculoskeletal medicine

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https://www.readbyqxmd.com/read/28639702/bone-marrow-aspirate-clot-a-technical-complication-or-a-smart-approach-for-musculoskeletal-tissue-regeneration
#1
REVIEW
F Salamanna, D Contartese, N Nicoli Aldini, G Barbanti Brodano, C Griffoni, A Gasbarrini, M Fini
One of the methods employed to improve healing of damaged tissues is the use of cellular based therapies. A number of regenerative medicine based strategies, from in vitro expanded mesenchymal stem cells (MSCs) to "one-step" procedures using bone marrow (BM) in toto (BM aspirate; BMA) or BM concentrate (BMC), have been developed. Recently, orthopedic researchers focused their attention on the clinical therapeutic potential of BMC and BMA for musculoskeletal regeneration. BMA is reported as an excellent source of cells and growth factors...
June 22, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28628049/early-access-to-physical-therapy-and-specialty-care-management-for-american-workers-with-musculoskeletal-injuries
#2
Timothy D Phillips, Michael J Shoemaker
OBJECTIVE: The aim of this study was to investigate the effect of very early access to physical therapy and specialty care management in a workers' compensation population. METHODS: A prospective pilot (n = 75) was conducted from 2012 to 2013 in which injured workers with musculoskeletal complaints received physical therapy and started care management during their initial occupational medicine clinic visit. Two retrospective comparator groups with workers' compensation claims from 2009 and 2012 were included in this study...
April 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28619299/comparative-cost-analysis-of-inpatient-integrative-medicine-results-of-a-pilot-study
#3
Thomas Ostermann, Romy Lauche, Holger Cramer, Gustav Dobos
BACKGROUND: Costs of integrative treatment alone and in comparison with other treatment approaches have scarcely been reported in the past. This study presents results of a comparative cost analysis of an inpatient integrative medicine treatment costs. METHODS: Data from 2006 for inpatients referred to a Department of Integrative Medicine in Germany were used. Case-related treatment costs were calculated, and transformed into Casemix-Indices and revenues per DRG...
June 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28617653/systematic-review-of-the-effect-of-taping-techniques-on-patellofemoral-pain-syndrome
#4
Catherine A Logan, Abhiram R Bhashyam, Ashley J Tisosky, Daniel B Haber, Anna Jorgensen, Adam Roy, Matthew T Provencher
CONTEXT: Taping is commonly used in the management of several musculoskeletal conditions, including patellofemoral pain syndrome (PFPS). Specific guidelines for taping are unknown. OBJECTIVE: To investigate the efficacy of knee taping in the management of PFPS. Our hypothesis was that tension taping and exercise would be superior to placebo taping and exercise as well as to exercise or taping alone. DATA SOURCES: The PubMed/MEDLINE, Cochrane, Rehabilitation and Sports Medicine Source, and CINAHL databases were reviewed for English-language randomized controlled trials (RCTs) evaluating the efficacy of various taping techniques that were published between 1995 and April 2015...
June 1, 2017: Sports Health
https://www.readbyqxmd.com/read/28604925/association-of-adverse-events-with-antibiotic-use-in-hospitalized-patients
#5
Pranita D Tamma, Edina Avdic, David X Li, Kathryn Dzintars, Sara E Cosgrove
Importance: Estimates of the incidence of overall antibiotic-associated adverse drug events (ADEs) in hospitalized patients are generally unavailable. Objective: To describe the incidence of antibiotic-associated ADEs for adult inpatients receiving systemic antibiotic therapy. Design, Setting, and Participants: Retrospective cohort of adult inpatients admitted to general medicine wards at an academic medical center. Exposures: At least 24 hours of any parenteral or oral antibiotic therapy...
June 12, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28597709/philippine-academy-of-rehabilitation-medicine-emergency-basic-relief-and-medical-aid-mission-project-november-2013-february-2014-the-role-of-physiatrists-in-super-typhoon-haiyan
#6
Filipinas Ganchoon, Rommel Bugho, Liezel Calina, Rochelle Dy, James Gosney
BACKGROUND: Physiatrists have provided humanitarian assistance in recent large-scale global natural disasters. Super Typhoon Haiyan, the deadliest and most costly typhoon in modern Philippine history, made landfall on 8 November 2013 resulting in significant humanitarian needs. METHODS: Philippine Academy of Rehabilitation Medicine physiatrists conducted a project of 23 emergency basic relief and medical aid missions in response to Super Typhoon Haiyan from November 2013 to February 2014...
June 9, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28595567/cartilage-tissue-regeneration-the-roles-of-cells-stimulating-factors-and-scaffolds
#7
Kui Huang, Qing Li, Yong Li, Zhihao Yao, Daowen Luo, Pengcheng Rao, Jingang Xiao
Cartilage tissue engineering is an emerging technique for the regeneration of cartilage tissue damaged as a result of trauma or disease. As the propensity for healing and regenerative capabilities of articular cartilage are limited, its repair remains one of the most challenging issues of musculoskeletal medicine. Clinical treatments intended to promote the success and complete repair of partial- and full-thickness articular cartilage defects are still unpredictable. However, one of the most exciting theories is that treatment of damaged articular cartilage can be realized with cartilage tissue engineering...
June 7, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28595566/a-systemic-review-of-the-sources-of-adult-mesenchymal-stem-cells-and-their-suitability-in-musculoskeletal-applications
#8
Rhiannon Nancarrow-Lei, Pouya Mafi, Reza Mafi, Wasim Khan
Background: Adult mesenchymal stem cells (MSCs) were first isolated from bone marrow by Friedenstein in 1976. These cells were clonogenic, non-haematopoietic, and able to replicate extensively in vitro. The fields of regenerative medicine and tissue engineering have grown dramatically since their inception. In the decades since, MSCs have been identified from mesoderm-, endoderm- and ectoderm-derived tissues. In light of our ageing population, the need for effective cell-based therapies for tissue repair and regeneration is ever-expanding...
June 8, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28574097/functionalized-biomimetic-calcium-phosphates-for-bone-tissue-repair
#9
Adriana Bigi, Elisa Boanini
The design and development of novel materials for biomineralized tissues is an extremely attractive field of research where calcium phosphates (CaPs)-based materials for biomedical applications play a leading role. The biological performance of these compounds can be enhanced through functionalization with biologically active ions and molecules. This review reports on some important recent achievements in creating functionalized biomimetic CaP materials for applications in the musculoskeletal field. Particular attention is focused on the modifications of these inorganic compounds with bioactive ions, growth factors and drugs, as well as on recent trends in some important CaP applications as biomaterials - namely, as bone cements, coatings of metallic implants and scaffolds for regenerative medicine...
May 29, 2017: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/28567371/the-use-of-finite-element-analyses-to-design-and-fabricate-three-dimensional-scaffolds-for-skeletal-tissue-engineering
#10
REVIEW
Wim J Hendrikson, Clemens A van Blitterswijk, Jeroen Rouwkema, Lorenzo Moroni
Computational modeling has been increasingly applied to the field of tissue engineering and regenerative medicine. Where in early days computational models were used to better understand the biomechanical requirements of targeted tissues to be regenerated, recently, more and more models are formulated to combine such biomechanical requirements with cell fate predictions to aid in the design of functional three-dimensional scaffolds. In this review, we highlight how computational modeling has been used to understand the mechanisms behind tissue formation and can be used for more rational and biomimetic scaffold-based tissue regeneration strategies...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28560466/real-life-effectiveness-of-spa-therapy-in-rheumatic-and-musculoskeletal-diseases-a-retrospective-study-of-819-patients
#11
Mine Karagülle, Sinan Kardeş, Müfit Zeki Karagülle
The objective of this study is to determine the use and efficacy of spa therapy in patients with a wide spectrum of rheumatic and musculoskeletal diseases under real-life clinical practice circumstances. In this retrospective observational study at the Medical Ecology and Hydroclimatology Department of Istanbul Faculty of Medicine, the records of all adult patients with rheumatic and musculoskeletal diseases who were prescribed a spa therapy in various health resorts in Turkey between 2002 and 2012 were analyzed...
May 30, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28558746/characteristics-of-therapeutic-alliance-in-musculoskeletal-physiotherapy-and-occupational-therapy-practice-a-scoping-review-of-the-literature
#12
Folarin Babatunde, Joy MacDermid, Norma MacIntyre
BACKGROUND: Most conventional treatment for musculoskeletal conditions continue to show moderate effects, prompting calls for ways to increase effectiveness, including drawing from strategies used across other health conditions. Therapeutic alliance refers to the relational processes at play in treatment which can act in combination or independently of specific interventions. Current evidence guiding the use of therapeutic alliance in health care arises largely from psychotherapy and medicine literature...
May 30, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28555307/the-influence-of-ancient-greek-thought-on-fifteenth-century-anatomy-galenic-influence-and-leonardo-da-vinci
#13
EDITORIAL
Richard Isaiah Tubbs, Jocelyn Gonzales, Joe Iwanaga, Marios Loukas, Rod J Oskouian, R Shane Tubbs
Leonardo da Vinci (1452-1519) can be called one of the earliest contributors to the history of anatomy and, by extension, the study of medicine. He may have even overshadowed Andreas Vesalius (1514-1564), the so-called founder of human anatomy, if his works had been published within his lifetime. While some of the best illustrations of their time, with our modern knowledge of anatomy, it is clear that many of da Vinci's depictions of human anatomy are inaccurate. However, he also made significant discoveries in anatomy and remarkable predictions of facts he could not yet discover with the technology available to him...
May 29, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28553357/human-adipose-derived-stem-cells-exhibit-enhanced-proliferative-capacity-and-retain-multipotency-longer-than-donor-matched-bone-marrow-mesenchymal-stem-cells-during-expansion-in-vitro
#14
Kimberley L Burrow, Judith A Hoyland, Stephen M Richardson
Bone marrow-derived mesenchymal stem cells (MSCs) and adipose-derived multipotent/mesenchymal stem cells (ASCs) have been proposed as the ideal cell types for a range of musculoskeletal tissue engineering and regenerative medicine therapies. However, extensive in vitro expansion is required to generate sufficient cells for clinical application and previous studies have demonstrated differences in the proliferative capacity and the impact of expansion on differentiation capacity of both MSCs and ASCs. Significantly, these studies routinely use cells from different donors, making direct comparisons difficult...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28551498/nasal-chondrocytes-as-a-neural-crest-derived-cell-source-for-regenerative-medicine
#15
REVIEW
Karoliina Pelttari, Marcus Mumme, Andrea Barbero, Ivan Martin
Cells deriving from neural crest are generally acknowledged during embryonic development for their multipotency and plasticity, accounting for their capacity to generate various cell and tissue types even across germ layers. At least partial preservation of some of these properties in adulthood makes neural crest derived cells of large interest for regenerative purposes. Chondrocytes from fully mature nasal septum cartilage in adults are also derivatives of neural crest cells and were recently demonstrated to be able not only to maintain functionality across serial cloning, as surrogate self-renewal test, but also to respond and adapt to heterotopic transplantation sites...
May 25, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28534604/the-influence-of-expectations-on-improvements-in-pain-and-function-in-patients-with-neck-back-shoulder-complaints-a-cohort-study
#16
Sigrid Skatteboe, Cecilie Røe, Morten W Fagerland, Lars-Petter Granan
BACKGROUND: In musculoskeletal research, patients' expectations have recently received increased attention. However, few prospective studies have investigated these expectations or their prognostic significance and possible clinical value. AIM: To investigate the influence of patients' expectations on improvements in pain and functional status six months after an outpatient physical medicine assessment. DESIGN: A prospective cohort study. SETTING: Physical Medicine and Rehabilitation (PMR) outpatient clinic...
May 23, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28527504/telehealth-in-physical-medicine-and-rehabilitation-a-narrative-review
#17
REVIEW
Adam S Tenforde, Jaye E Hefner, Jodi E Kodish-Wachs, Mary A Iaccarino, Sabrina Paganoni
Telehealth refers to health care interactions that leverage telecommunication devices to provide medical care outside the traditional face-to-face, in-person medical encounter. Technology advances and research have expanded use of telehealth in health care delivery. Physical medicine and rehabilitation providers may use telehealth to deliver care to populations with neurologic and musculoskeletal conditions, commonly treated in both acute care and outpatient settings. Patients with impaired mobility and those living in locations with reduced access to care may particularly benefit...
May 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28509821/minimum-information-for-studies-evaluating-biologics-in-orthopaedics-mibo-platelet-rich-plasma-and-mesenchymal-stem-cells
#18
Iain R Murray, Andrew G Geeslin, Ewan B Goudie, Frank A Petrigliano, Robert F LaPrade
BACKGROUND: A comprehensive approach to the evaluation of biologic therapies for musculoskeletal conditions is required to guide appropriate future use. Clinical studies evaluating platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) are limited by inadequate reporting of scientific details critical to outcome. We developed minimum reporting requirements for clinical studies evaluating PRP and MSCs using Delphi consensus methods. METHODS: The need for consensus on the minimum reporting requirements for studies evaluating biologics was identified at the American Academy of Orthopaedic Surgeons/Orthopaedic Research Society (AAOS/ORS) Biologic Treatments for Orthopaedic Injuries Symposium in 2015 and the American Orthopaedic Society for Sports Medicine (AOSSM) Biologic Treatments for Sports Injuries II Think Tank in 2015...
May 17, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28503221/management-of-musculoskeletal-pain-in-retail-drug-outlets-within-a-nigerian-community-a-descriptive-study
#19
Samirah N Abdu-Aguye, Aishatu Shehu, Ubaidullah I Ahmad
OBJECTIVE: This work aimed to describe attitudes and practices of both community pharmacies and patent and proprietary medicine vendor (PPMV) outlets towards over-the-counter (OTC) analgesic use for musculoskeletal pain states within Zaria, Nigeria. METHODS: The study was carried out in 2 phases from May to August 2016. Phase one was a cross-sectional survey of 40 retail drug outlets (10 community pharmacies and 30 PPMVs). A simulated patient scenario of a young adult male complaining of acute onset back pain was used to collect data on the type and quality of analgesic recommended, duration of consultation, as well as nature of information provided during the drug dispensing process...
January 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/28502741/high-metabolic-activity-of-tissue-nonspecific-alkaline-phosphatase-not-only-in-young-but-also-in-adult-bone-as-demonstrated-using-a-new-histochemical-detection-protocol
#20
I Piotr Maly, Elisabeth Eppler, Magdalena Müller-Gerbl
Tissue-nonspecific alkaline phosphatase (TNAP) is playing a key role in bone calcification, as has been demonstrated in different mammalian species including human and rodents. However, to investigate age-related changes during life history, histochemical demonstration of TNAP is severely hampered, particularly in the elderly, by technical difficulties associated with sectioning calcified tissue. Sufficient fixation must precede decalcification since poorly fixed bone tissue is exposed to the deleterious effects of decalcification reagents...
May 11, 2017: General and Comparative Endocrinology
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