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Dong Chen, Jiang Liu, Hui-Ying Zhao, Yi-Peng Chen, Zun Xiang, Xi Jin
AIM: To investigate the expression pattern of plasma long noncoding RNAs (lncRNAs) in Chrohn's disease (CD) patients. METHODS: Microarray screening and qRT-PCR verification of lncRNAs and mRNAs were performed in CD and control subjects, followed by hierarchy clustering, GO and KEGG pathway analyses. Significantly dysregulated lncRNAs were categorized into subgroups of antisense lncRNAs, enhancer lncRNAs and lincRNAs. To predict the regulatory effect of lncRNAs on mRNAs, a CNC network analysis was performed and cross linked with significantly changed lncRNAs...
May 21, 2016: World Journal of Gastroenterology: WJG
Kelly B Jouris, Jennifer L McDaniel, Edward P Weiss
Omega-3 fatty acids (omega-3) have anti-inflammatory properties. However, it is not known if omega-3 supplementation attenuates exercise-induced inflammation. We tested the hypothesis that omega-3 supplementation reduces inflammation that is induced by eccentric arm curl exercise. Healthy adult men and women (n=11; 35 ± 10 y) performed eccentric biceps curls on two occasions, once after 14d of dietary omega-3 restriction (control trial) and again after 7d of 3,000 mg/d omega-3 supplementation (omega-3 trial)...
2011: Journal of Sports Science & Medicine
Jacob Juel, Arne Vidar Tind Wøyen, Mogens Vyberg, Ulrik Tage-Jensen
A 38-year-old man with a ten year long history of primary sclerosing cholangitis without previous symptoms of inflammatory bowel disease was admitted to hospital after a few weeks with abdominal pain, diarrhoea and fever. A computed tomography revealed that the colon was dilated to a diameter of 17 cm. Based on a diagnosis of toxic megacolon, a subtotal colectomy and an ileostomy were carried out. Gross and histological examination showed changes compatible with Crohn's disease. Ten years' history of primary sclerosing cholangitis before onset of inflammatory bowel disease is very unusual, and toxic colon as the initial symptom of Crohn's disease is rare...
August 26, 2013: Ugeskrift for Laeger
G H Tee, G Kaur, P Ramanathan, N M Amal, K Chinna
About 1.8 million people die annually from acute diarrheal disease globally. A nationwide cross-sectional survey was conducted via face-to-face interview with eligible subjects to determine the incidence and health seeking behavior of Malaysians with acute diarrheal disease (ADD). An acute diarrheal episode was defined as having three or more loose stools in any 24 hour period during the four weeks period prior to the interview. The exclusion criteria included pre-existing chronic diarrhea, such as with cancer of the bowel, ulcerative colitis or Chrohn's disease...
March 2011: Southeast Asian Journal of Tropical Medicine and Public Health
James E Clark, Negin Sarafraz, Michael S Marber
Chronic heart failure is debilitating, often fatal, expensive to treat and common. In most patients it is a late consequence of myocardial infarction (MI). The intracellular signals following infarction that lead to diminished contractility, apoptosis, fibrosis and ultimately heart failure are not fully understood but probably involve p38-mitogen activated protein kinases (p38), a family of serine/threonine kinases which, when activated, cause cardiomyocyte contractile dysfunction and death. Pharmacological inhibitors of p38 suppress inflammation and are undergoing clinical trials in rheumatoid arthritis, Chrohn's disease, psoriasis and surgery-induced tissue injury...
November 2007: Pharmacology & Therapeutics
L Casciola, G Ceccarelli, M Stefanoni, A Spaziani, D Conti, A Bartoli, L Di Zitti, R Valeri, R Bellochi, M Rambotti
AIM: About 2/3 of the Western population over the age of 80 years are affected by colic diverticulosis; 25% will develop diverticular disease with or without complications: fistula, obstruction, pericolic abscess, free perforation or hemorrhage. Laparoscopic approach for benign diseases of the colon such as diverticulosis, Chrohn's disease, etc. is unanimously considered as a very effective procedure. We have performed a retrospective analysis of 9 years with laparoscopic approach of the diverticular disease...
February 2006: Minerva Chirurgica
No abstract text is available yet for this article.
June 1957: Jornal da Sociedade Das Ciências Médicas de Lisboa
Marko Duvnjak, Lucija Virovic
The inflammatory bowel disease is common term for heterogenous group of the chronic recidivant idiopathic diseases with bowel inflammation as a common sign. Although within common term, traditionally we distinguish two diseases, Chrohns disease (CD) and ulcerative colitis (UC), in certain clinical situations those terms are not sufficient to describe all variants of inflammatory bowel diseases. Today increasingly, we have more and more knowledge about clinical, immunological, genetical heterogenicity in Crohns disease and ulcerative colitis...
2002: Medicinski Arhiv
S J van Deventer
The cause of inflammatory bowel diseases is unknown, but T-cells play an important part in the pathogenesis of Crohn's disease. It was shown in recent years that activated T-cells produce certain cytokines that cause inflammation (interferon-alpha, tumour necrosis factor-alpha or TNF-alpha), but also cytokines (interleukin-10 or IL-10, transforming growth factor-alpha) which on the contrary inhibit inflammation. On the basis of this knowledge, the mucosal inflammatory reaction can be counteracted in a rational manner: antibodies against TNF-alpha in most patients with Crohn's disease who failed to respond to corticosteroids led to substantial reduction of disease activity...
October 11, 1997: Nederlands Tijdschrift Voor Geneeskunde
K Lehr, O Schober, H Hundeshagen, R Pichlmayr
Significant intracellular potassium depletion was documented in 57 patients with Crohn's disease by measurements of total body potassium, body water compartments, and red cell Na,K-ATPase units. Total body potassium deficits paralleled the activity of illness, but were not correlated to serum potassium levels. Treatment before surgery to improve individual body potassium content resulted in a reduced surgical mortality and complication rate compared with a retrospective series of 56 patients in whom pretreatment had simply been aimed at normalizing serum albumin and other standard serum parameters...
December 1982: Annals of Surgery
G Bendixen
No abstract text is available yet for this article.
1970: Tijdschrift Voor Gastro-enterologie
A Lazarov, M Sahpazov, M Lazarevski
No abstract text is available yet for this article.
1971: Godis̆en Zbornik Na Medicinskiot Fakultet Vo Skopje
P Jouanneau, P Teniere
No abstract text is available yet for this article.
March 1973: Annales de Chirurgie
E Soppi, J Eskola, O P Lehtonen, R Leino
Different immune functions of 10 patients with glutein-sensitive enteropathy (GSE), 9 with Crohn's disease (CD), 11 with ulcerative colitis (UC) and 13 healthy controls were characterized. The numbers of suppressor T cells in GSE were comparable to those of the controls; otherwise, the lymphocyte subpopulations were decreased in these bowel diseases. In the whole-blood cultures, the lymphocyte proliferative responses to PHA were normal in the bowel diseases, but the responses to Con A were decreased in CD. In cultures with D-penicillamine, the inhibition of the helper effect of CD patients was more pronounced in PHA-stimulated cultures than in Con A-stimulated cultures...
September 1988: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
J Alexander-Williams
No abstract text is available yet for this article.
September 1976: Diseases of the Colon and Rectum
R S Fishman, C R Fleming, D H Stephens
Crohn's colitis has recently been shown to predispose the patient to cancer of the colon. Unfortunately, many of the manifestations of colonic malignancy, such as polypoid intraluminal masses and strictures, can be simulated roentgenographically by Crohn's colitis. We present five patients in whom this diagnostic difficulty arose. As established by total or subtotal colectomy, none proved to have malignancy; instead, pronounced transmural inflammation and, in two cases, multiple large pseudopolyps were found to account for the roentgenographically indeterminate lesions...
July 1978: Mayo Clinic Proceedings
P Kirkegaard, F Weile, F W Henriksen, O V Nielsen, J Christiansen
Resection with the object of cure was undertaken in 20 patients with Crohn's disease in the terminal ileum. These patients were followed up more than five years after operation. Recurrence took place in eight patients, in half of them more than five years after the primary operation. Six patients were submitted to reoperation and two died. Seven out of the eight recurrences were localized to the anastomosis. These results may support the results of a bigger Swedish material which favours more radical primary resections in Crohn's disease...
1978: Acta Chirurgica Scandinavica
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