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https://www.readbyqxmd.com/read/28930787/use-of-google-trends-to-examine-interest-in-mohs-micrographic-surgery-2004-to-2016
#1
Daniel J Callaghan
BACKGROUND: Mohs micrographic surgery (MMS) is the gold standard for treatment of high-risk skin cancers. There has been an upward trend in the use of this procedure as demonstrated by data from Medicare and the National Ambulatory Medical Care Survey. OBJECTIVE: To assess interest in MMS among members of the general public as measured by number of online searches, and how that interest has changed over time. MATERIALS AND METHODS: Google Trends was used to plot interest in search terms including "Mohs surgery," "basal cell carcinoma," "squamous cell carcinoma," "melanoma," and "skin cancer" from January 1, 2004, to November 30, 2016...
September 19, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28925583/decreasing-incidence-of-cancer-after-liver-transplantation-a-nordic-population-based-study-over-three-decades
#2
A Nordin, F Åberg, E Pukkala, C R Pedersen, H H Storm, A Rasmussen, W Bennet, M Olausson, H Wilczek, B-G Ericzon, S Tretli, P-D Line, T H Karlsen, K M Boberg, H Isoniemi
Cancer remains one of the most serious long-term complications after liver transplantation (LT). Data for all adult LT patients between 1982 and 2013 was extracted from the Nordic Liver Transplant Registry. Through linkage with respective national cancer-registry data, we calculated standardized incidence ratios (SIRs) based on country, sex, calendar time, and age-specific incidence rates. Altogether 461 cancers were observed in 424 individuals out the 4246 LT patients during a mean 6.6-year follow-up. The overall SIR was 2...
September 19, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28924456/cutaneous-malignant-melanoma-incidences-analyzed-worldwide-by-sex-age-and-skin-type-over-personal-ultraviolet-b-dose-shows-no-role-for-sunburn-but-implies-one-for-vitamin-d3
#3
Dianne E Godar, Madhan Subramanian, Stephen J Merrill
Because the incidence of cutaneous malignant melanoma (CMM) was reported to increase with increasing terrestrial UVR (290-400 nm) doses in the US back in 1975 and a recent publication showed no association exists with UVR exposure at all, we set out to fully elucidate the role of UVR in CMM. To achieve this goal, we analyzed the CMM incidences over latitude and estimated the average personal UVR dose in the US and numerous countries (> 50) on 5 continents around the world. Using data from the International Agency for Research on Cancer in 2005, we performed worldwide analysis of CMM over UVR dose by sex, age group (0-14, 15-29, 30-49, 50-69, 70-85+) and Fitzpatrick skin types I-VI...
2017: Dermato-endocrinology
https://www.readbyqxmd.com/read/28923399/up-regulation-of-rho-associated-kinase-1-2-by-glucocorticoids-promotes-migration-invasion-and-metastasis-of-melanoma
#4
Gao-Xiang Huang, Yan Wang, Jie Su, Peng Zhou, Bo Li, Li-Juan Yin, Jian Lu
Although glucocorticoids (GCs) regulate proliferation, differentiation and apoptosis of tumor cells, their influence on metastasis of tumor cells is poorly understood. Melanoma is a type of skin cancers with high metastasis. We investigated the effect of GCs on metastasis of melanoma cells and its mechanism. We found that GCs significantly promoted the adhesion, migration, invasion of melanoma cells in vitro and lung metastasis in experimental melanoma metastasis mice. Dexamethasone (Dex), a synthetic GC, did not change the RhoA, RhoB and RhoC signalings, but significantly increased the expression and activity of Rho-associated kinase 1/2 (ROCK1/2)...
September 15, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28919783/toll-like-receptors-7-and-8-expression-correlates-with-the-expression-of-immune-biomarkers-and-positively-predicts-the-clinical-outcome-of-patients-with-melanoma
#5
Moucheng Zhang, Zhilong Yan, Junjiang Wang, Xueqing Yao
BACKGROUND: Toll-like receptors (TLRs) play a critical role in cancer, yet the clinical relevance of TLR7/8 expression in melanoma remains unclear. This study aimed to evaluate the prognostic value of TLR7/8 mRNA levels in melanoma and their correlation with immune biomarkers relevant to disease progression. METHODS: Normalized gene expression and corresponding clinical data of patients with skin cutaneous melanoma were obtained from two public databases: the Cancer Genome Atlas and GSE19234...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28919418/the-nampt-e2f2-sirt1-axis-promotes-proliferation-and-inhibits-p53-dependent-apoptosis-in-human-melanoma-cells
#6
Hailong Zhao, Weiwei Tang, Xiaowen Chen, Siyu Wang, Xianyan Wang, Haiyan Xu, Lijuan Li
Melanoma is the most common primary malignant neoplasm in adults, causing more deaths than any other skin cancer, necessitating the development of new target-based approaches. Current evidence suggests SIRT1, the mammalian nicotinamide adenine dinucleotide (NAD(+))-dependent protein deacetylase, and nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting NAD(+) biosynthetic enzyme, together comprise a novel systemic regulatory network to play a pivotal role in cell proliferation and apoptosis. Nevertheless, how the regulation of this cofactor interfaces with signal transduction network remains poorly understood in melanoma...
September 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28915278/differential-diagnosis-of-seborrheic-keratosis-clinical-and-dermoscopic-features
#7
Ralph P Braun, Sabine Ludwig, Ashfaq A Marghoob
<p>Seborrheic keratosis (SK) is a benign epidermal keratinocytic tumor that is extremely common, particularly in individuals over the age of 50. Most individuals with SK will have more than one lesion and the presence of over 10 lesions in the same person is not uncommon. Although the clinical morphology of most SK with their stuck-on, symmetric, keratotic, and waxy appearance makes them easy to identify, many manifest a morphology resembling melanoma or squamous cell carcinoma. One can argue that such cases will ultimately not prove to be problematic since a simple biopsy will easily reveal their benign nature and eliminate any concerns...
September 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28914692/increasing-suicide-risk-among-cancer-patients-in-lithuania-from-1993-to-2012-a-cancer-registry-based-study
#8
Auguste Kaceniene, Agne Krilaviciute, Jurgita Kazlauskiene, Giedre Bulotiene, Giedre Smailyte
Certain groups of individuals seem to have an increased risk of committing suicide, and a number of studies have reported an increased risk of suicide among cancer patients. In this study, we aim to estimate the risk of suicide among cancer patients in Lithuania over the period 1993-2012. The records of patients diagnosed with primary cancer were extracted from the population-based Lithuanian Cancer Registry and 273 511 cases of first cancer were included in the analysis. Sex, age and calendar period-standardized mortality ratios (SMRs) were calculated by dividing the observed numbers of suicides among cancer patients by the expected number using national rates...
September 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28914690/incidence-trends-and-survival-of-skin-melanoma-and-squamous-cell-carcinoma-in-cluj-county-romania
#9
Ofelia Şuteu, Mihaiela L Blaga, Florian Nicula, Patricia Şuteu, Ovidiu Coza, Patriciu Achimaş-Cadariu, Daniela Coza
The aim of this study was to determine the incidence trends of cutaneous melanoma (CM) and squamous cell carcinoma (SCC) in Cluj County, from 1998 to 2011, and the 5-year net survival between 2006 and 2010. Data on all cases of CM and SCC between 1998 and 2011 were obtained from Cluj Cancer Registry. Incidence rates were age standardized by the direct method Age Standardized Incidence Rate (ASIR), using the world standard population. Trends and annual percentage change (APC) of incidence rates were calculated by joinpoint regression analysis...
September 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28898461/risks-of-different-skin-tumor-combinations-after-a-first-melanoma-squamous-cell-carcinoma-and-basal-cell-carcinoma-in-dutch-population-based-cohorts-1989-2009
#10
R J T van der Leest, L M Hollestein, L Liu, T Nijsten, E de Vries
BACKGROUND: Skin cancer patients are primarily at increased risk of developing subsequent skin cancers of the same type. Shared risk factors might also increase the occurrence of a different type of subsequent skin cancer. OBJECTIVE: To investigate risks of different skin tumor combinations after a first melanoma, squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). METHODS: All melanoma and SCC patients included in the national Netherlands Cancer Registry (NCR) and all BCC patients included in the regional Eindhoven Cancer Registry (ECR) between 1989 and 2009 were followed until diagnosis of a subsequent different skin cancer (melanoma, SCC or BCC), date of death or end of study...
September 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28895666/current-standards-of-surgical-management-in-primary-melanoma
#11
Matthew C Perez, Sonia T Orcutt, Jonathan S Zager
Melanoma accounts for the majority of skin cancer-related deaths, and its incidence continues to rise worldwide. While advanced disease has historically been associated with poor long-term survival, early-stage disease has a favorable prognosis and therefore, early diagnosis is paramount. Resection of primary melanoma requires a balance of maximizing oncological outcome while minimizing morbidity. Wide excision with 1-2 cm margins, depending on depth of the tumor, is the standard of care for surgical treatment of primary, invasive melanoma...
September 12, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28890210/photodynamic-therapy-an-option-in-mycosis-fungoides
#12
Pileri Alessandro, Sgubbi Paola, Agostinelli Claudio, Infusino Salvatore Domenico, Vaccari Sabina, Patrizi Annalisa
BACKGROUND: Photodynamic therapy (PDT) is a well-known and effective treatment for non-melanoma skin-cancer. Numerous studies have also shown its effectiveness in mycosis fungoides. The aim of the study was to analyse MF patients treated with PDT at the Dermatology Unit of Bologna University. METHODS: We retrospectively analysed MF patients treated with PDT over the last ten years. Each PDT protocol consisted of the appliance for 3h under an occlusive film dressing on each lesion of a one-mm-thick layer of 16% methyl aminolaevulinate (MAL) 160mg/g cream (Metvix(®), Galderma, Paris, France)...
September 7, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28888850/ultrasound-based-follow-up-does-not-increase-survival-in-early-stage-melanoma-patients-a-comparative-cohort-study
#13
S Ribero, S Podlipnik, S Osella-Abate, E Sportoletti-Baduel, E Manubens, A Barreiro, V Caliendo, M Chavez-Bourgeois, C Carrera, P Cassoni, J Malvehy, M T Fierro, S Puig
INTRODUCTION: Different protocols have been used to follow up melanoma patients in stage I-II. However, there is no consensus on the complementary tests that should be requested or the appropriate intervals between visits. Our aim is to compare an ultrasound-based follow-up with a clinical follow-up. PATIENTS AND METHODS: Analysis of two prospectively collected cohorts of melanoma patients in stage IB-IIA from two tertiary referral centres in Barcelona (clinical-based follow-up [C-FU]) and Turin (ultrasound-based follow-up [US-FU])...
September 7, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28887295/photoaging-mobile-apps-in-school-based-melanoma-prevention-pilot-study
#14
Titus Josef Brinker, Christian Martin Brieske, Christoph Matthias Schaefer, Fabian Buslaff, Martina Gatzka, Maximilian Philip Petri, Wiebke Sondermann, Dirk Schadendorf, Ingo Stoffels, Joachim Klode
BACKGROUND: Around 90% of melanomas are caused by exposure to ultraviolet (UV) radiation and are therefore eminently preventable. Tanning behavior is mostly initiated in early adolescence, often with the belief that it increases attractiveness; the problems related to malignant melanoma and other skin cancers are too far in the future to fathom. Given the substantial amount of time children and adolescents spend in schools, as well as with their mobile phones, addressing melanoma prevention via both of these ways is crucial...
September 8, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28886814/integrating-skin-cancer-related-technologies-into-clinical-practice
#15
REVIEW
Richard R Winkelmann, Aaron S Farberg, Alex M Glazer, Clay J Cockerell, Arthur J Sober, Daniel M Siegel, Sancy A Leachman, Whitney A High, Orit Markowitz, Brian Berman, David M Pariser, Gary Goldenberg, Theodore Rosen, Darrell S Rigel
Early diagnosis and treatment of melanoma improve survival. New technologies are emerging that may augment the diagnosis, assessment, and management of melanoma but penetrance into everyday practice is low. In the current health care climate, greater emphasis will be placed on the incorporation of technology for clinically suspicious pigmented lesions to facilitate better, more cost-effective management.
October 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28886812/smartphone-based-applications-for-skin-monitoring-and-melanoma-detection
#16
REVIEW
Elizabeth Chao, Chelsea K Meenan, Laura K Ferris
With the advancement of mobile technologies, smartphone applications (apps) have become widely available and gained increasing attention as a novel tool to deliver dermatologic care. This article presents a review of various apps for skin monitoring and melanoma detection and a discussion of current limitations in the field of dermatology. Concerns regarding quality, transparency, and reliability have emerged because there are currently no established quality standards or regulatory oversight of mobile medical apps...
October 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28886808/assessing-skin-cancer-using-epidermal-genetic-information-retrieved-by-adhesive-patch-skin-surface-sampling
#17
REVIEW
Nayoung Lee, Alon Scope, Harold Rabinovitz
The detection of melanoma can be challenging. Many patients have clinically equivocal lesions in cosmetically sensitive areas or have multiple suspicious lesions. Epidermal genetic information retrieval is a noninvasive diagnostic method involving the application of adhesive tape onto the skin's surface to recover genomic material from the epidermis. This genomic material can then be used in assays to determine gene expression profiles. Studies have shown the potential of this technology to aid clinicians in differentiating between melanomas and nevi...
October 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28886807/proteomic-mass-spectrometry-imaging-for-skin-cancer-diagnosis
#18
REVIEW
Rossitza Lazova, Erin H Seeley
Mass spectrometry imaging can be successfully used for skin cancer diagnosis, particularly for the diagnosis of challenging melanocytic lesions. This method analyzes proteins within benign and malignant melanocytic tumor cells and, based on their differences, which constitute a unique molecular signature of 5 to 20 proteins, can render a diagnosis of benign nevus versus malignant melanoma. Mass spectrometry imaging may assist in the differentiation between metastases and nevi as well as between proliferative nodules in nevi and melanoma arising in a nevus...
October 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28886804/electrical-impedance-spectroscopy-in-skin-cancer-diagnosis
#19
REVIEW
Ralph P Braun, Johanna Mangana, Simone Goldinger, Lars French, Reinhard Dummer, Ashfaq A Marghoob
Electrical impedance spectroscopy (EIS) is a noninvasive method that aims to help diagnose skin cancer. The EIS device consists of a handheld probe with a disposable electrode that is applied directly on the skin and uses electrical impendence differences to differentiate between normal and abnormal skin lesions. The EIS algorithm is best used on lesions that are deemed clinically or dermoscopically suspicious and has a high sensitivity in detecting malignant melanoma. The greatest usefulness of EIS is achieved in conjunction with a physician who has experience with this modality and excellent training in the clinical detection of suspicious lesions...
October 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28886798/enhancing-skin-cancer-diagnosis-with-dermoscopy
#20
REVIEW
Zachary J Wolner, Oriol Yélamos, Konstantinos Liopyris, Tova Rogers, Michael A Marchetti, Ashfaq A Marghoob
Dermoscopy increases the sensitivity for skin cancer detection, decreases the number of benign lesions biopsied for each malignant diagnosis, and enables the diagnosis of thinner melanomas compared with naked eye examination. Multiple meta-analyses have identified that dermoscopy improves the diagnostic accuracy for melanoma when compared with naked eye examination. In addition, studies have established that dermoscopy can aid in the detection of keratinocyte carcinomas. Dermoscopy triage algorithms have been developed to help novices decide when a biopsy or a referral is most appropriate...
October 2017: Dermatologic Clinics
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