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Chronic fatigue syndrome

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https://www.readbyqxmd.com/read/27908630/non-linear-dose-response-of-aluminium-hydroxide-adjuvant-particles-selective-low-dose-neurotoxicity
#1
Guillemette Crépeaux, Housam Eidi, Marie-Odile David, Yasmine Baba-Amer, Eleni Tzavara, Bruno Giros, François-Jérôme Authier, Christopher Exley, Christopher A Shaw, Josette Cadusseau, Romain K Gherardi
Aluminium (Al) oxyhydroxide (Alhydrogel(®)), the main adjuvant licensed for human and animal vaccines, consists of primary nanoparticles that spontaneously agglomerate. Concerns about its safety emerged following recognition of its unexpectedly long-lasting biopersistence within immune cells in some individuals, and reports of chronic fatigue syndrome, cognitive dysfunction, myalgia, dysautonomia and autoimmune/inflammatory features temporally linked to multiple Al-containing vaccine administrations. Mouse experiments have documented its capture and slow transportation by monocyte-lineage cells from the injected muscle to lymphoid organs and eventually the brain...
November 28, 2016: Toxicology
https://www.readbyqxmd.com/read/27905944/methods-of-applying-the-1994-case-definition-of-chronic-fatigue-syndrome-impact-on-classification-and-observed-illness-characteristics
#2
E R Unger, J-M S Lin, H Tian, B M Gurbaxani, R S Boneva, J F Jones
BACKGROUND: Multiple case definitions are in use to identify chronic fatigue syndrome (CFS). Even when using the same definition, methods used to apply definitional criteria may affect results. The Centers for Disease Control and Prevention (CDC) conducted two population-based studies estimating CFS prevalence using the 1994 case definition; one relied on direct questions for criteria of fatigue, functional impairment and symptoms (1997 Wichita; Method 1), and the other used subscale score thresholds of standardized questionnaires for criteria (2004 Georgia; Method 2)...
March 12, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27904120/high-frequency-rtms-for-the-treatment-of-chronic-fatigue-syndrome-a-case-series
#3
Wataru Kakuda, Ryo Momosaki, Naoki Yamada, Masahiro Abo
Structural and functional abnormalities of the prefrontal cortex seem to correlate with fatigue in patients with chronic fatigue syndrome (CFS). We consecutively applied facilitatory high-frequency repetitive transcranial magnetic stimulation (rTMS) to the dorsolateral prefrontal cortex (DLPFC) of seven CFS patients over three days. Five patients completed the 3-day protocol without any adverse events. For the other two patients, we had to reduce the stimulation intensity in response to mild adverse reactions...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27898261/tiredness-and-fatigue-during-processes-of-illness-and-recovery-a-qualitative-study-of-women-recovered-from-fibromyalgia-syndrome
#4
Hedda Eik Grape, Kari Nyheim Solbrække, Marit Kirkevold, Anne Marit Mengshoel
Fibromyalgia syndrome (FMS), a chronic musculoskeletal pain condition, is often accompanied by fatigue. In this study, inspired by narrative approaches to health and illness, we explore how women who have regained their health after FMS describe tiredness along a storyline from before they fell ill, through their illness, recovery process, and present-day health. The data derive from qualitative interviews with eight Norwegian women who previously suffered from FMS but who no longer had the condition at the time of interview...
November 29, 2016: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/27894380/an-attention-and-interpretation-bias-for-illness-specific-information-in-chronic-fatigue-syndrome
#5
A M Hughes, T Chalder, C R Hirsch, R Moss-Morris
BACKGROUND: Studies have shown that specific cognitions and behaviours play a role in maintaining chronic fatigue syndrome (CFS). However, little research has investigated illness-specific cognitive processing in CFS. This study investigated whether CFS participants had an attentional bias for CFS-related stimuli and a tendency to interpret ambiguous information in a somatic way. It also determined whether cognitive processing biases were associated with co-morbidity, attentional control or self-reported unhelpful cognitions and behaviours...
November 29, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27886247/acupuncture-and-moxibustion-have-different-effects-on-fatigue-by-regulating-the-autonomic-nervous-system-a-pilot-controlled-clinical-trial
#6
Qing Shu, Hua Wang, Daniela Litscher, Song Wu, Li Chen, Ingrid Gaischek, Lu Wang, Wenjuan He, Huanjiao Zhou, Gerhard Litscher, Fengxia Liang
In order to investigate the different effects of acupuncture and moxibustion on chronic fatigue syndrome (CFS) and alterations in the autonomic nervous system by measuring heart rate variability (HRV). Forty-five participants were recruited and randomly divided into 3 groups using a randomization schedule. The control group (CG, n = 15) and the acupuncture group (AG, n = 15) were treated by manipulation acupuncture, and the moxibustion group (MG, n = 15) was treated by indirect moxibustion. Primary outcomes were the scores of the Fatigue Assessment Instrument (FAI)...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27884793/sex-stress-and-sleep-apnoea-decreased-susceptibility-to-upper-airway-muscle-dysfunction-following-intermittent-hypoxia-in-females
#7
REVIEW
Ken D O'Halloran, Philip Lewis, Fiona McDonald
Obstructive sleep apnoea syndrome (OSAS) is a devastating respiratory control disorder more common in men than women. The reasons for the sex difference in prevalence are multifactorial, but are partly attributable to protective effects of oestrogen. Indeed, OSAS prevalence increases in post-menopausal women. OSAS is characterized by repeated occlusions of the pharyngeal airway during sleep. Dysfunction of the upper airway muscles controlling airway calibre and collapsibility is implicated in the pathophysiology of OSAS, and sex differences in the neuro-mechanical control of upper airway patency are described...
November 21, 2016: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/27884012/gut-microbiota-bacterial-translocation-and-interactions-with-diet-pathophysiological-links-between-major-depressive-disorder-and-non-communicable-medical-comorbidities
#8
Anastasiya Slyepchenko, Michael Maes, Felice N Jacka, Cristiano A Köhler, Tatiana Barichello, Roger S McIntyre, Michael Berk, Iria Grande, Jane A Foster, Eduard Vieta, André F Carvalho
BACKGROUND: Persistent low-grade immune-inflammatory processes, oxidative and nitrosative stress (O&NS), and hypothalamic-pituitary-adrenal axis activation are integral to the pathophysiology of major depressive disorder (MDD). The microbiome, intestinal compositional changes, and resultant bacterial translocation add a new element to the bidirectional interactions of the gut-brain axis; new evidence implicates these pathways in the patho-aetiology of MDD. In addition, abnormalities in the gut-brain axis are associated with several chronic non-communicable disorders, which frequently co-occur in individuals with MDD, including but not limited to irritable bowel syndrome (IBS), chronic fatigue syndrome (CFS), obesity, and type 2 diabetes mellitus (T2DM)...
November 25, 2016: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/27883945/recent-advances-in-the-treatment-of-lower-risk-non-del-5q-myelodysplastic-syndromes-mds
#9
REVIEW
Antonio Almeida, Pierre Fenaux, Alan F List, Azra Raza, Uwe Platzbecker, Valeria Santini
Patients with lower-risk myelodysplastic syndromes (MDS) are affected primarily by symptoms of chronic anemia and fatigue rather than progression to acute myeloid leukemia. Severe thrombocytopenia, although less common in lower-risk MDS, is associated with increased risk of bleeding. For anemic patients, the principal aim of treatment is to improve anemia and decrease red blood cell transfusions. For transfusion-dependent patients with lower-risk MDS without chromosome 5q deletion [non-del(5q) MDS], there are limited effective treatments...
November 13, 2016: Leukemia Research
https://www.readbyqxmd.com/read/27881065/lipids-at-the-cross-road-of-autoimmunity-in-multiple-sclerosis
#10
Marcella Reale, Silvia Sánchez-Ramón
Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system (CNS) characterized by demyelination and neurodegeneration, driven by a Th17/Th1-immune response, which afflicts mainly young women. Although MS causes are not completely known, it is notorious that the disease is characterized by an extended focal degradation of the myelin sheath, with ulterior axon and neuronal damage. Lipid molecules play a main dual role in MS, both as target molecules of myelin destruction and as mediators of inflammation...
November 22, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27846770/the-relationship-between-balance-and-vitamin-25-oh-d-in-fibromyalgia-patients
#11
Meliha Kasapoğlu Aksoy, Lale Altan, Burcu Ökmen Metin
: INTRODUCTİON: Fibromyalgia syndrome (FMS) is a chronic disease characterized by diffuse pain of unknown cause, fatigue, sleep disorders, cognitive dysfunction and sensitivity. Fibromyalgia was shown to be associated with balance problems and increased incidence of falls. There are many theoretical mechanisms related to the impact of vitamin D on postural control. The aim of the current study was to investigate the relationship between vitamin 25(OH)D levels and pain, balance and daily activities in patients with FMS...
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27846583/for-chronic-fatigue-syndrome-a-shifting-tide-at-nih
#12
Meredith Wadman
No abstract text is available yet for this article.
November 11, 2016: Science
https://www.readbyqxmd.com/read/27845196/chronic-fatigue-syndrome-and-chronic-widespread-pain-in-adolescence-population-birth-cohort-study
#13
Tom Norris, Kevin Deere, Jon H Tobias, Esther Crawley
: Whilst many studies have investigated the overlap between pain phenotypes and chronic fatigue syndrome (CFS) in adults, little is known about the relationship between these conditions in adolescents. The study's aim was therefore to identify whether a relationship exists between chronic widespread pain (CWP) and CFS in adolescents and investigate whether the two share common associations with a set of covariates. A questionnaire was administered to offspring of the Avon Longitudinal Study of Parents and Children at age 17, asking about site, duration, and pain intensity, from which participants with CWP were identified...
November 11, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27842587/experiences-of-general-practitioner-continuity-among-women-with-chronic-fatigue-syndrome-myalgic-encephalomyelitis-a-cross-sectional-study
#14
Anne Helen Hansen, Olaug S Lian
BACKGROUND: Continuity of care is important for patients with chronic illness in need of coordinated healthcare services from multiple providers. Little is known about how patients with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) experience continuity of GP care. This study explores how women with CFS/ME experience GP care across the three dimensions of continuity: informational, management, and relational continuity. METHODS: This cross-sectional study uses questionnaire data collected from members of The Norwegian ME Association...
November 14, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27835969/a-targeted-genome-association-study-examining-transient-receptor-potential-ion-channels-acetylcholine-receptors-and-adrenergic-receptors-in-chronic-fatigue-syndrome-myalgic-encephalomyelitis
#15
Samantha Johnston, Donald Staines, Anne Klein, Sonya Marshall-Gradisnik
BACKGROUND: Chronic Fatigue Syndrome, also known as Myalgic Encephalomyelitis (CFS/ME) is a debilitating condition of unknown aetiology. It is characterized by a range of physiological effects including neurological, sensory and motor disturbances. This study examined candidate genes for the above clinical manifestations to identify single nucleotide polymorphism (SNP) alleles associated with CFS/ME compared with healthy controls. METHODS: DNA was extracted and whole genome genotyping was performed using the HumanOmniExpress BeadChip array...
November 11, 2016: BMC Medical Genetics
https://www.readbyqxmd.com/read/27834303/single-nucleotide-polymorphisms-and-genotypes-of-transient-receptor-potential-ion-channel-and-acetylcholine-receptor-genes-from-isolated-b-lymphocytes-in-myalgic-encephalomyelitis-chronic-fatigue-syndrome-patients
#16
Sonya Marshall-Gradisnik, Samantha Johnston, Anu Chacko, Thao Nguyen, Peter Smith, Donald Staines
OBJECTIVE: The pathomechanism of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is unknown; however, a small subgroup of patients has shown muscarinic antibody positivity and reduced symptom presentation following anti-CD20 intervention. Given the important roles of calcium (Ca(2+)) and acetylcholine (ACh) signalling in B cell activation and potential antibody development, we aimed to identify relevant single nucleotide polymorphisms (SNPs) and genotypes in isolated B cells from CFS/ME patients...
November 10, 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/27827985/reply-to-comment-on-detection-of-mycotoxin-in-patients-with-chronic-fatigue-syndrome-toxins-2013-5-605-617-by-mark-j-mendell
#17
Joseph Brewer, Jack Dwayne Thrasher, Dennis Hooper
The authors of [1] have received further correspondence from Mark J. Mendell [2] concerning the above paper.[...].
November 7, 2016: Toxins
https://www.readbyqxmd.com/read/27827984/comment-on-detection-of-mycotoxins-in-patients-with-chronic-fatigue-syndrome-toxins-2013-5-605-617
#18
Mark J Mendell
The paper by Brewer et al. (2013) has a key methodologic flaw [1].[...].
November 7, 2016: Toxins
https://www.readbyqxmd.com/read/27827983/reply-to-comment-on-detection-of-mycotoxins-in-patients-with-chronic-fatigue-syndrome-toxins-2013-5-605-617-by-john-w-osterman-m-d
#19
Joseph Brewer, Jack Dwayne Thrasher, Dennis Hooper
This paper [1] was an observational case study.[...].
November 7, 2016: Toxins
https://www.readbyqxmd.com/read/27827982/comment-on-detection-of-mycotoxins-in-patients-with-chronic-fatigue-syndrome-toxins-2013-5-605-617
#20
John W Osterman
The paper by Brewer et al. entitled "Detection of Mycotoxins in Patients with Chronic Fatigue Syndrome.[...].
November 7, 2016: Toxins
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