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Chronic fatigue syndrome

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https://www.readbyqxmd.com/read/29348374/-neurologic-abnormalities-in-myalgic-encephalomyelitis-chronic-fatigue-syndrome-a-review
#1
Anthony L Komaroff, Ryosuke Takahashi, Takashi Yamamura, Masanori Sawamura
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is an illness characterized by fatigue lasting for at least six months, post-exertional malaise, unrefreshing sleep, cognitive impairment and orthostatic intolerance. ME/CFS has been a controversial illness because it is defined exclusively by subjective complaints. However, recent studies of neuroimaging as well as analysis of blood markers, energy metabolism and mitochondrial function have revealed many objective biological abnormalities. Specifically, it is suspected that the symptoms of ME/CFS may be triggered by immune activation - either inside or outside the brain - through release of inflammatory cytokines...
January 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29348373/-immunopathogenesis-of-myalgic-encephalomyelitis-chronic-fatigue-syndrome-me-cfs
#2
Takashi Yamamura, Hirohiko Ono, Wakiro Sato
A recent study on the pathogenesis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) has revealed an elevation of inflammatory and anti-inflammatory cytokines in the sera and cerebrospinal fluids of the patients and presence of autoantibodies in subgroups of ME/CFS patients. Furthermore, investigator-initiated clinical trials have proved the efficacy of anti-CD20 antibody (rituximab), that eliminate B cells, in the treatment of ME/CFS. Based on these findings, we hypothesize that immune abnormalities, such as enhanced autoimmune responses, may play an essential role in the neuroinflammatory pathogenesis of ME/CFS...
January 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29348372/-new-diagnostic-biomarkers-for-chronic-fatigue-syndrome
#3
Emi Yamano, Yosky Kataoka
Chronic fatigue syndrome (CFS) is a persistent and unexplained pathological state characterized by exertional and severely debilitating fatigue, with/without symptoms of infection or neuropsychiatric symptoms, and with a minimum duration of 6 consecutive months. The pathogenesis of CFS is not fully understood. There are no firmly established diagnostic biomarkers or treatment, due to incomplete understanding of the etiology of CFS and diagnostic uncertainty. We performed comprehensive metabolomic analyses of blood samples obtained from patients with CFS and healthy controls to establish an objective diagnosis of CFS...
January 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29348371/-neuroinflammation-in-the-brain-of-patients-with-myalgic-encephalomyelitis-chronic-fatigue-syndrome
#4
Yasuhito Nakatomi, Hirohiko Kuratsune, Yasuyoshi Watanabe
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by chronic, profound, disabling, and unexplained fatigue; cognitive impairment; and chronic widespread pain. By using positron emission tomography, our study demonstrated neuroinflammation in the brain of patients with ME/CFS. Neuroinflammation was found to be widespread in the brain areas of the patients with ME/CFS and was associated with the severity of their neuropsychological symptoms. The ongoing research would lead to the establishment of objective diagnostic criteria and development of an appropriate therapy...
January 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29348370/-diagnosis-and-treatment-of-myalgic-encephalomyelitis-chronic-fatigue-syndrome
#5
Hirohiko Kuratsune
We present here the Japanese clinical diagnostic criteria for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) that were proposed in 2016 by the Japanese Ministry of Health, Labour and Welfare study group. The clinical diagnosis criteria of ME/CFS were created to be used by healthcare agencies in charge of primary care practice. We also explain the current prognosis in ME/CFS and medical treatments used in major medical institutions in Japan.
January 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29348369/-history-of-researches-on-myalgic-encephalomyelitis-chronic-fatigue-syndrome
#6
Yasuyoshi Watanabe, Hirohiko Kuratsune
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease characterized by chronic, profound, disabling, and unexplained fatigue. The first patient with ME/CFS in Japan was identified and described in 1990 by Prof. Teruo Kitani and Dr. Hirohiko Kuratsune of the Research Institute for Microbial Diseases, Osaka University. Since then, a variety of studies have been performed to determine the objective biomarkers of the disease. Although it is hypothesized that brain inflammation is involved in the pathophysiology of ME/CFS, there is to date no direct evidence of neuroinflammation in patients with ME/CFS...
January 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29340774/-exercise-to-me-is-a-scary-word-perceptions-of-fatigue-sleep-dysfunction-and-exercise-in-people-with-fibromyalgia-syndrome-a-focus-group-study
#7
D Russell, I C Álvarez Gallardo, I Wilson, C M Hughes, G W Davison, B Sañudo, J G McVeigh
Fibromyalgia syndrome (FMS) is a common and complex chronic pain condition. Exercise is recommended in the management of the FMS; however, people with FMS often find exercise exacerbates their condition and causes overwhelming fatigue. The objective of this study was to explore the perceptions of fatigue and sleep dysfunction, and exercise in people with FMS. Three, 60-90 min focus groups were conducted with people with FMS (n = 14). Participants were recruited from patient support groups who had experienced therapeutic exercise in the management of their condition...
January 16, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29330767/ivabradine-for-the-treatment-of-postural-orthostatic-tachycardia-syndrome-a-systematic-review
#8
REVIEW
Megan E Gee, Alicia K Watkins, Jamie N Brown, Emily J A Young
INTRODUCTION: Postural orthostatic tachycardia syndrome (POTS) impacts millions of patients, but there is currently no gold standard treatment for this condition. Ivabradine is a novel heart rate (HR) lowering agent that acts on the sinoatrial node cells by selectively inhibiting the If-current. OBJECTIVE: The objective of this systematic review is to evaluate the evidence for the efficacy and safety of ivabradine for the treatment of POTS. METHODS: MEDLINE (from 1956 to August 2017) and EMBASE (from 1957 to August 2017) were queried with the following search term: "postural orthostatic tachycardia syndrome" OR "postural tachycardia syndrome" OR "chronic orthostatic intolerance" AND "ivabradine...
January 12, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29318645/endometriosis-increased-the-risk-of-bladder-pain-syndrome-interstitial-cystitis-a-population-based-study
#9
Chia-Chang Wu, Shiu-Dong Chung, Herng-Ching Lin
OBJECTIVE: Previous studies have suggested an association between bladder pain syndrome/interstitial cystitis (BPS/IC) and endometriosis. However, no nation-wide population study has yet reported an association between them. In this study, we examined the risk of BPS/IC among subjects with endometriosis during a 3-year follow-up in Taiwan using a population-based dataset. STUDY DESIGN: This study comprised 9191 subjects with endometriosis, and 27 573 subjects randomly selected as controls...
January 10, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29317049/autoimmunity-against-a-glycolytic-enzyme-as-a-possible-cause-for-persistent-symptoms-in-lyme-disease
#10
Paolo Maccallini, Serena Bonin, Giusto Trevisan
Some patients with a history of Borrelia burgdorferi infection develop a chronic symptomatology characterized by cognitive deficits, fatigue, and pain, despite antibiotic treatment. The pathogenic mechanism that underlines this condition, referred to as post-treatment Lyme disease syndrome (PTLDS), is currently unknown. A debate exists about whether PTLDS is due to persistent infection or to post-infectious damages in the immune system and the nervous system. We present the case of a patient with evidence of exposure to Borrelia burgdorferi sl and a long history of debilitating fatigue, cognitive abnormalities and autonomic nervous system issues...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29311748/integrated-analysis-of-gene-expression-differences-in-twins-discordant-for-disease-and-binary-phenotypes
#11
Sivateja Tangirala, Chirag J Patel
While both genes and environment contribute to phenotype, deciphering environmental contributions to phenotype is a challenge. Furthermore, elucidating how different phenotypes may share similar environmental etiologies also is challenging. One way to identify environmental influences is through a discordant monozygotic (MZ) twin study design. Here, we assessed differential gene expression in MZ discordant twin pairs (affected vs. non-affected) for seven phenotypes, including chronic fatigue syndrome, obesity, ulcerative colitis, major depressive disorder, intermittent allergic rhinitis, physical activity, and intelligence quotient, comparing the spectrum of genes differentially expressed across seven phenotypes individually...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29305552/venetoclax-for-patients-with-chronic-lymphocytic-leukemia-who-progressed-during-or-after-idelalisib-therapy
#12
Steven Coutre, Michael Choi, Richard R Furman, Herbert Eradat, Leonard Heffner, Jeffrey A Jones, Brenda Chyla, Lang Zhou, Suresh Agarwal, Tina Waskiewicz, Maria Verdugo, Rod A Humerickhouse, Jalaja Potluri, William G Wierda, Matthew S Davids
B-cell receptor pathway inhibitors (BCRi) have transformed treatment for chronic lymphocytic leukemia (CLL); however, efficacy of therapies for patients whose disease is refractory to/relapses after (R/R) BCRi is unknown. Venetoclax is a selective, orally bioavailable BCL-2 inhibitor with activity in patients with CLL, including those who are heavily pretreated or have 17p deletion. This phase 2 study prospectively evaluated venetoclax in patients with R/R CLL after ibrutinib or idelalisib; here we report on patients who received idelalisib as the last BCRi prior to enrollment...
January 5, 2018: Blood
https://www.readbyqxmd.com/read/29300036/a-reboot-for-chronic-fatigue-syndrome-research
#13
Amy Maxmen
No abstract text is available yet for this article.
January 4, 2018: Nature
https://www.readbyqxmd.com/read/29297728/chronic-fatigue-and-immune-deficiency-syndrome-cfids-cellular-metabolism-and-ionizing-radiation-a-review-of-contemporary-scientific-literature-and-suggested-directions-for-future-research
#14
Andrej Rusin, Colin Seymour, Carmel Mothersill
PURPOSE: To investigate biochemical pathways known to be involved in radiation response and in CFIDS to determine if there might be common underlying mechanisms leading to symptoms experienced by those accidentally or deliberately exposed to radiation and those suffering from CFIDS. If such a link were established, to suggest testable hypotheses to investigate the mechanisms with the aim of identifying new therapeutic targets. CONCLUSIONS: Evidence for involvement of the alpha-synuclein, cytochrome c oxidiase, αB-crystallin, RNase L, and lactate dehydrogenase/STAT1 pathways is strong and suggests a common underlying mechanism involving mitochondrial dysfunction mediated by ROS and disruption of ATP production...
January 3, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29284500/cytokine-signatures-in-chronic-fatigue-syndrome-patients-a-case-control-study-and-the-effect-of-anakinra-treatment
#15
Megan E Roerink, Hans Knoop, Ewald M Bronkhorst, Henk A Mouthaan, Luuk J A C Hawinkels, Leo A B Joosten, Jos W M van der Meer
BACKGROUND: Cytokine disturbances have been suggested to be associated with the Chronic Fatigue Syndrome/Myalgic encephalomyelitis (CFS/ME) for decades. METHODS: Fifty female CFS patients were included in a study on the effect of the interleukin-1-receptor antagonist anakinra or placebo during 4 weeks. EDTA plasma was collected from patients before and directly after treatment. At baseline, plasma samples were collected at the same time from 48 healthy, age-matched female neighborhood controls...
December 29, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29283590/tutorial-the-practical-application-of-longitudinal-structural-equation-mediation-models-in-clinical-trials
#16
Kimberley A Goldsmith, David P MacKinnon, Trudie Chalder, Peter D White, Michael Sharpe, Andrew Pickles
The study of mediation of treatment effects, or how treatments work, is important to understanding and improving psychological and behavioral treatments, but applications often focus on mediators and outcomes measured at a single time point. Such cross-sectional analyses do not respect the implied temporal ordering that mediation suggests. Clinical trials of treatments often provide repeated measures of outcomes and, increasingly, of mediators as well. Repeated measurements allow the application of various types of longitudinal structural equation mediation models...
December 28, 2017: Psychological Methods
https://www.readbyqxmd.com/read/29279512/bilateral-adrenal-hemorrhage-in-a-patient-with-antiphospholipid-syndrome-during-chronic-graft-versus-host-disease
#17
Mariko Minami, Tsuyoshi Muta, Masahiro Adachi, Masakazu Higuchi, Kenichi Aoki, Ryosuke Ogawa
We present the case of a 56-year-old man with an upper respiratory infection followed by fatigue, hypotension, and hyponatremia. Bilateral adrenal hemorrhage was confirmed, based on T2-weighted magnetic resonance imaging. The patient had previously undergone allogeneic hematopoietic stem cell transplantation and had been diagnosed with antiphospholipid syndrome (APS) during the development of chronic graft-versus-host disease. A prompt diagnosis and steroid replacement, in addition to anticoagulant therapy, resulted in a favorable outcome...
December 27, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29278731/a-test-of-the-adaptive-network-explanation-of-functional-disorders-using-a-machine-learning-analysis-of-symptoms
#18
Christos Melidis, Susan L Denham, Michael E Hyland
The classification and etiology of functional disorders is controversial. Evidence supports both psychological and biological (disease) models that show, respectively, that functional disorders should be classified as one (bodily distress syndrome) and many (e.g., irritable bowel syndrome (IBS), fibromyalgia syndrome (FMS), and chronic fatigue syndrome (CFS)). Two network models (symptom network and adaptive network) can explain the specificity and covariation of symptomatology, but only the adaptive network model can explain the covariation of the somatic symptoms of functional disorders...
December 23, 2017: Bio Systems
https://www.readbyqxmd.com/read/29275790/the-clinical-utility-of-metacognitive-beliefs-and-processes-in-emotional-distress-in-people-with-multiple-sclerosis
#19
Philip Heffer-Rahn, Peter L Fisher
AIM: Multiple sclerosis (MS) is a chronic demyelinating disease that poses significant life challenges. Depression and anxiety often occur in people with MS (PwMS). An information processing model of psychopathology, the Self-Regulatory Executive Function (S-REF) model specifies that maladaptive metacognitive beliefs play a fundamental role in the development and maintenance of distress. The model also asserts that a style of thinking known as the cognitive attentional syndrome (CAS), which consists of worry and rumination, focusing on sources of threat, and unhelpful coping responses, is common across all psychological conditions...
January 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29275786/glucocorticoid-receptor-dna-methylation-and-childhood-trauma-in-chronic-fatigue-syndrome-patients
#20
Elise Beau Vangeel, Stefan Kempke, Jelena Bakusic, Lode Godderis, Patrick Luyten, Leen Van Heddegem, Veerle Compernolle, Philippe Persoons, Diether Lambrechts, Benedetta Izzi, Kathleen Freson, Stephan Claes
OBJECTIVE: Although the precise mechanisms are not yet understood, previous studies have suggested that chronic fatigue syndrome (CFS) is associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation and trauma in early childhood. Consistent with findings suggesting that early life stress-induced DNA methylation changes may underlie dysregulation of the HPA axis, we previously found evidence for the involvement of glucocorticoid receptor (GR) gene (NR3C1) methylation in whole blood of CFS patients...
January 2018: Journal of Psychosomatic Research
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