keyword
https://read.qxmd.com/read/34008156/roles-of-the-notch-signaling-pathway-in-ovarian-functioning
#1
JOURNAL ARTICLE
Shuhan Guo, Song Quan, Siyi Zou
The Notch signaling pathway regulates cell invasion, adhesion, proliferation, apoptosis, and differentiation via cell-to-cell interactions and plays important physiological roles in the ovary. This review summarizes current knowledge about the Notch signaling pathway in relation to ovarian functions and reveals the potential underlying mechanisms. We conducted an in-depth review of relevant literature to determine the current status of research into the Notch signaling pathway in relation to ovarian functioning and reveal potential underlying mechanisms...
October 2021: Reproductive Sciences
https://read.qxmd.com/read/26645720/the-expression-of-markers-related-to-ovarian-germline-stem-cells-in-the-mouse-ovarian-surface-epithelium-and-the-correlation-with-notch-signaling-pathway
#2
JOURNAL ARTICLE
Zezheng Pan, Mengli Sun, Jia Li, Fangyue Zhou, Xia Liang, Jian Huang, Tuochen Zheng, Liping Zheng, Yuehui Zheng
BACKGROUND/AIMS: Ovarian germline stem cells (OGSCs) have been shown to mainly exist in the ovarian surface epithelium (OSE), but the activity changes of germline stem cells during different reproductive stages and the potential regulatory signaling pathway are still unknown. The Notch signaling pathway plays a key role in cell development, primordial follicles and stem cell proliferation. However, whether it plays a role in the proliferation of OGSCs is unknown. Here, we analyzed the activity changes of germline stem cells and the correlation between germline stem cells and the Notch signaling pathway...
2015: Cellular Physiology and Biochemistry
https://read.qxmd.com/read/26289531/involvement-of-notch-signaling-in-early-chick-ovarian-follicle-development
#3
JOURNAL ARTICLE
Jun Li, Dan Zhao, Changquan Guo, Jian Li, Yuling Mi, Caiqiao Zhang
The formation of primordial follicles is a crucial process in the establishment of follicle pools required for the female's reproductive life span. For laying hens, ample follicles are a prerequisite for high laying performance. Notch signaling plays critical roles in germ cell cysts breakdown and in the formation of primordial follicles. Here, we investigated the role of Notch signaling in the ovarian development of post-hatch chicks. Results showed that around post-hatch day 4 (H4), the germ cell cysts broke apart, oocytes became surrounded by squamous pregranulosa cells, and the primordial follicles were then formed...
January 2016: Cell Biology International
https://read.qxmd.com/read/24430295/primordial-follicle-assembly-was-regulated-by-notch-signaling-pathway-in-the-mice
#4
JOURNAL ARTICLE
Chun-Lei Chen, Xia-Fei Fu, Lin-Qing Wang, Jun-Jie Wang, Hua-Gang Ma, Shun-Feng Cheng, Zhu-Mei Hou, Jin-Mei Ma, Guo-Bo Quan, Wei Shen, Lan Li
Notch signaling pathway, a highly conserved cell signaling system, exists in most multicellular organisms. The objective of this study was to examine Notch signaling pathway in germ cell cyst breakdown and primordial follicle formation. The receptor and ligand genes of Notch pathway (Notch1, Notch2, Jagged1, Jagged2 and Hes1) were extremely down-regulated after newborn mouse ovaries were cultured then exposed to DAPT or L-685,458 in vitro (P < 0.01). Since DAPT or L-685,548 inhibits Notch signaling pathway, the expression of protein LHX8 and NOBOX was significantly reduced during the formation of the primordial follicles...
March 2014: Molecular Biology Reports
https://read.qxmd.com/read/24398584/notch-pathway-regulates-female-germ-cell-meiosis-progression-and-early-oogenesis-events-in-fetal-mouse
#5
JOURNAL ARTICLE
Yan-Min Feng, Gui-Jin Liang, Bo Pan, Xun-Si Qin, Xi-Feng Zhang, Chun-Lei Chen, Lan Li, Shun-Feng Cheng, Massimo De Felici, Wei Shen
A critical process of early oogenesis is the entry of mitotic oogonia into meiosis, a cell cycle switch regulated by a complex gene regulatory network. Although Notch pathway is involved in numerous important aspects of oogenesis in invertebrate species, whether it plays roles in early oogenesis events in mammals is unknown. Therefore, the rationale of the present study was to investigate the roles of Notch signaling in crucial processes of early oogenesis, such as meiosis entry and early oocyte growth. Notch receptors and ligands were localized in mouse embryonic female gonads and 2 Notch inhibitors, namely DAPT and L-685,458, were used to attenuate its signaling in an in vitro culture system of ovarian tissues from 12...
2014: Cell Cycle
https://read.qxmd.com/read/22652674/p4-down-regulates-jagged2-and-notch1-expression-during-primordial-folliculogenesis
#6
JOURNAL ARTICLE
Meng Guo, Hua Zhang, Fenghua Bian, Ge Li, Xinyi Mu, Jing Wen, Guankun Mao, Zhen Teng, Guoliang Xia, Meijia Zhang
Nest breakdown and primordial folliculogenesis of the mouse ovary can be inhibited by progesterone (P4) and Notch signaling inhibitors. However, the relationship between these two signals during this process remains unknown. In the present study, transcript levels of Jagged2, Notch1, and their target, Hey2, increased markedly in ovaries during the beginning stage of folliculogenesis (17.5 days post coitus (dpc) to birth). Maternal P4 levels decreased simultaneously. We found that maternal midpregnancy P4 levels significantly inhibited Jagged2, Notch1, and Hey2 expression, and follicle formation in vitro...
June 1, 2012: Frontiers in Bioscience (Elite Edition)
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