Meng Guo, Hua Zhang, Fenghua Bian, Ge Li, Xinyi Mu, Jing Wen, Guankun Mao, Zhen Teng, Guoliang Xia, Meijia Zhang
Nest breakdown and primordial folliculogenesis of the mouse ovary can be inhibited by progesterone (P4) and Notch signaling inhibitors. However, the relationship between these two signals during this process remains unknown. In the present study, transcript levels of Jagged2, Notch1, and their target, Hey2, increased markedly in ovaries during the beginning stage of folliculogenesis (17.5 days post coitus (dpc) to birth). Maternal P4 levels decreased simultaneously. We found that maternal midpregnancy P4 levels significantly inhibited Jagged2, Notch1, and Hey2 expression, and follicle formation in vitro...
June 1, 2012: Frontiers in Bioscience (Elite Edition)