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leucemia linfoide

Chiara Gregorj, Maria R Ricciardi, Maria T Petrucci, Maria C Scerpa, Fabiana De Cave, Paola Fazi, Marco Vignetti, Antonella Vitale, Marco Mancini, Giuseppe Cimino, Salvatore Palmieri, Francesco Di Raimondo, Giorgina Specchia, Francesco Fabbiano, Nicola Cantore, Federico Mosna, Andrea Camera, Mario Luppi, Luciana Annino, Eustachio Miraglia, Giuseppe Fioritoni, Francesca Ronco, Giovanna Meloni, Franco Mandelli, Michael Andreeff, Michele Milella, Robin FoĆ , Agostino Tafuri et al.
Extracellular signal-regulated kinase-1/2 (ERK1/2) is frequently found constitutively activated (p-ERK1/2) in hematopoietic diseases, suggesting a role in leukemogenesis. The aim of this study was to assess the expression and clinical role of p-ERK1/2 in adult acute lymphoblastic leukemia (ALL). In 131 primary samples from adult de novo ALL patients enrolled in the Gruppo Italiano per le Malattie Ematologiche dell'Adulto (GIMEMA) Leucemia Acute Linfoide (LAL) 2000 protocol and evaluated by flow cytometry, constitutive ERK1/2 activation was found in 34...
June 15, 2007: Blood
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