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https://www.readbyqxmd.com/read/29728130/low-dose-clomiphene-citrate-as-a-mild-stimulation-protocol-in-women-with-unsuspected-poor-in-vitro-fertilization-result-can-generate-more-oocytes-with-optimal-cumulative-pregnancy-rate
#1
Humphrey Ochin, Xiang Ma, Lin Wang, Xuan Li, Jie Song, Yan Meng, Jiandong Shen, Yu-Gui Cui, Jiayin Liu
BACKGROUND: The use of long protocol during controlled ovarian stimulation for assisted reproduction attracts high dosage of gonadotropins. High dose of gonadotropins can be detrimental to oocyte development, which affects its quality and compromises the treatment outcome. Mild stimulation protocols that attract low dose gonadotropins could be useful alternative regimen to address such problems. This study evaluated the efficacy of low dose clomiphene citrate based protocol plus low dose gonadotropins on predicted normal responder patients who had unsuspected poor in vitro fertilization (IVF) result, following an initial stimulation with long gonadotropin-releasing hormone (GnRH) agonist protocol...
May 4, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29695208/comparison-of-modified-agonist-mild-stimulation-and-antagonist-protocols-for-in-vitro-fertilization-in-patients-with-diminished-ovarian-reserve
#2
Rong Yu, Hao Jin, Xuefeng Huang, Jinju Lin, Peiyu Wang
Objective To compare the efficacy of three protocols for ovarian stimulation in patients with diminished ovarian reserve during in vitro fertilization (IVF) treatment. Methods This prospective randomized study enrolled patients with diminished ovarian reserve who underwent cycles of IVF or intracytoplasmic sperm injection. The patients were randomly divided into three groups: a modified gonadotrophin releasing hormone (GnRH) agonist protocol (group A); (ii) a mild stimulation protocol (group B); or (iii) an antagonist protocol (group C)...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29673660/comparison-of-antagonist-mild-and-long-agonist-protocols-in-terms-of-follicular-fluid-total-antioxidant-capacity
#3
Begum Aydogan Mathyk, Berna Aslan Cetin, Duygu Vardagli, Emel Zengin, Nigar Sofiyeva, Tulay Irez, Pelin Ocal
OBJECTIVE: A high dose of prolonged gonadotropins can yield higher numbers of oocytes and embryos. The high dose or prolonged regimens can be associated with ovarian hyperstimulation syndrome (OHSS), multiple gestations, emotional stress, economical burden and treatment dropout. In mild stimulation lower doses and shorter duration times of gonadotropin are used in contrast to the conventional long stimulation protocol in IVF. It has been proposed that supraphysiologic levels of hormones may adversely affect endometrium and oocyte/embryo...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29672007/how-general-semen-quality-influences-the-blastocyst-formation-rate-analysis-of-4205-ivf-cycles
#4
Mariana M Piccolomini, Tatiana Cs Bonetti, Eduardo La Motta, Paulo C Serafini, Jose R Alegretti
OBJECTIVE: To select embryos with higher implantation potential, the extended culture has been the most frequently applied strategy worldwide, and consequently leads to higher live birth rates per transfer. Sperm quality is a determining feature, and it may influence the outcomes of IVF from fertilization to embryo development. Therefore, we hypothesize that blastocyst formation may also be impaired by general semen quality. METHODS: We analyzed 4205 IVF cycles...
April 19, 2018: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29670831/predicting-visual-disability-in-glaucoma-with-combinations-of-vision-measures
#5
Stephanie Lin, Aleksandra Mihailovic, Sheila K West, Chris A Johnson, David S Friedman, Xiangrong Kong, Pradeep Y Ramulu
Purpose: We characterized vision in glaucoma using seven visual measures, with the goals of determining the dimensionality of vision, and how many and which visual measures best model activity limitation. Methods: We analyzed cross-sectional data from 150 older adults with glaucoma, collecting seven visual measures: integrated visual field (VF) sensitivity, visual acuity, contrast sensitivity (CS), area under the log CS function, color vision, stereoacuity, and visual acuity with noise...
April 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29609229/-cumulative-live-birth-rates-per-oocytes-retrieved-cycle-evaluation-of-clinical-outcomes-of-ivf-icsi
#6
C X Wu, T Zhang, L Shu, J Huang, F Y Diao, W Ding, Y Gao, W Wang, Y D Mao, Y G Cui, J Y Liu
Objective: Using of cumulative live birth rate (CLBR) per oocytes retrieved cycle, to assess the clinical outcomes of in vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI) , and to explore impact factors on CLBR following utilization of all fresh and frozen embryos in one complete IVF/ICSI cycle using gonadotropin-releasing hormone (GnRH) agonist, GnRH-antagonist and clomiphene mild stimulation protocols. Methods: Of the patients who underwent IVF/ICSI from January 1st, 2014 to December 31st, 2015 in the First Affiliated Hospital, Nanjing Medical University, a total of 6 142 oocytes retrieved cycles were included...
March 25, 2018: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29579270/analysis-of-segregation-patterns-of-quadrivalent-structures-and-the-effect-on-genome-stability-during-meiosis-in-reciprocal-translocation-carriers
#7
Shuo Zhang, Caixia Lei, Junping Wu, Haiyan Sun, Jing Zhou, Saijuan Zhu, Jialong Wu, Jing Fu, Yijuan Sun, Daru Lu, Xiaoxi Sun, Yueping Zhang
STUDY QUESTION: Do specific factors affect the segregation patterns of a quadrivalent structure and can the quadrivalent affect genome stability during meiosis? SUMMARY ANSWER: Meiotic segregation patterns can be affected by the carrier's gender and age, location of breakpoints and chromosome type, and the quadrivalent structure can increase genome instability during meiosis. WHAT IS KNOWN ALREADY: Carriers of reciprocal translocations have an increased genetic reproductive risk owing to the complex segregation patterns of a quadrivalent structure...
April 1, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29538638/natural-conception-rates-in-couples-with-unexplained-or-mild-male-subfertility-scheduled-for-fertility-treatment-a-secondary-analysis-of-a-randomized-controlled-trial
#8
R van Eekelen, R I Tjon-Kon-Fat, P M M Bossuyt, N van Geloven, M J C Eijkemans, A J Bensdorp, F van der Veen, B W Mol, M van Wely
STUDY QUESTION: What is the natural conception rate over the course of 12 months in couples with unexplained or mild male subfertility who are scheduled for fertility treatment and have a predicted unfavourable prognosis for natural conception? SUMMARY ANSWER: The natural conception rate over the course of 12 months in couples who were allocated to treatment was estimated to be 24.5% (95% CI: 20-29%). WHAT IS KNOWN ALREADY: After starting treatment, couples often perceive unsuccessful cycles as evidence of definitive failure even though they are still able to conceive naturally in between and after treatment...
March 12, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29500531/outcomes-of-poor-responders-following-growth-hormone-co-treatment-with-ivf-icsi-mild-stimulation-protocol-a-retrospective-cohort-study
#9
Kun Chu, Wenjuan Pang, Ningxia Sun, Qing Zhang, Wen Li
PURPOSE: No research has studied the effect of GH co-treatment in mild stimulation protocol for poor responders. We therefore conducted this retrospective analysis to assess the outcome of IVF/ICSI cycles after the adjunct GH use to the mild stimulation protocol in poor responders. METHODS: 132 poor responders who received mild stimulation protocol at Reproductive Medicine Center of Changzheng Hospital from January 2014 to December 2016 were included in this study...
May 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29334275/laparoscopic-ovarian-drilling-versus-gnrh-antagonist-combined-with-cabergoline-as-a-prophylaxis-against-the-re-development-of-ovarian-hyperstimulation-syndrome
#10
Emaduldin Seyam, Enas Hefzy
OBJECTIVE: The aim of this work was to investigate the value of laparoscopic ovarian drilling (LOD) compared with GnRH antagonist flexible protocol combined with cabergoline (Cb), as a prophylaxis against the re-development of ovarian hyperstimulation syndrome (OHSS) in women with clomiphene citrate-resistant polycystic ovary disease (CCR-PCOD) who had severe OHSS before in a previous ICSI cycle. STUDY DESIGN: It is a prospective controlled study, where 250 CCR-PCOD women (n = 250) with a history of severe OHSS before, had been recruited for the study...
January 15, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29231321/-efficacy-of-acupuncture-moxibustion-periodic-therapy-on-follicular-maldevelopment-differentiated-as-spleen-and-kidney-yang-deficiency
#11
Yuxuan Yan, Chang Pan, Jie Wu, Lijie Yang
OBJECTIVE: To observe the clinical efficacy of acupuncture and moxibustion periodic therapy on folli-cular maldevelopment differentiated as spleen and kidney yang deficiency. METHODS: Sixty patients of follicular maldevelopment differentiated as spleen and kidney yang deficiency were randomized as an observation group and a control group, 30 cases in each one. The conventional acupuncture-moxibustion therapy was used in the control group and the acupuncture-moxibustion periodic therapy was applied to the observation group...
January 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29121350/individualized-fsh-dosing-based-on-ovarian-reserve-testing-in-women-starting-ivf-icsi-a-multicentre-trial-and-cost-effectiveness-analysis
#12
Theodora C van Tilborg, Simone C Oudshoorn, Marinus J C Eijkemans, Monique H Mochtar, Ron J T van Golde, Annemieke Hoek, Walter K H Kuchenbecker, Kathrin Fleischer, Jan Peter de Bruin, Henk Groen, Madelon van Wely, Cornelis B Lambalk, Joop S E Laven, Ben Willem J Mol, Frank J M Broekmans, Helen L Torrance
STUDY QUESTION: Is there a difference in live birth rate and/or cost-effectiveness between antral follicle count (AFC)-based individualized FSH dosing or standard FSH dosing in women starting IVF or ICSI treatment? SUMMARY ANSWER: In women initiating IVF/ICSI, AFC-based individualized FSH dosing does not improve live birth rates or reduce costs as compared to a standard FSH dose. WHAT IS KNOWN ALREADY: In IVF or ICSI, ovarian reserve testing is often used to adjust the FSH dose in order to normalize ovarian response and optimize live birth rates...
December 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29121269/individualized-versus-standard-fsh-dosing-in-women-starting-ivf-icsi-an-rct-part-2-the-predicted-hyper-responder
#13
Simone C Oudshoorn, Theodora C van Tilborg, Marinus J C Eijkemans, G Jur E Oosterhuis, Jaap Friederich, Marcel H A van Hooff, Evert J P van Santbrink, Egbert A Brinkhuis, Jesper M J Smeenk, Janet Kwee, Corry H de Koning, Henk Groen, Cornelis B Lambalk, Ben Willem J Mol, Frank J M Broekmans, Helen L Torrance
STUDY QUESTION: Does a reduced FSH dose in women with a predicted hyper response, apparent from a high antral follicle count (AFC), who are scheduled for IVF/ICSI lead to a different outcome with respect to cumulative live birth rate and safety? SUMMARY ANSWER: Although in women with a predicted hyper response (AFC > 15) undergoing IVF/ICSI a reduced FSH dose (100 IU per day) results in similar cumulative live birth rates and a lower occurrence of any grade of ovarian hyperstimulation syndrome (OHSS) as compared to a standard dose (150 IU/day), a higher first cycle cancellation rate and similar severe OHSS rate were observed...
December 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29100809/comments-on-the-eshre-recommendations-for-the-treatment-of-minimal-endometriosis-in-infertile-women
#14
Angelos Daniilidis, George Pados
According to ESHRE recommendations for women with stage I/II endometriosis, if a decision is made to proceed to laparoscopy then operative laparoscopy (excision or ablation of the endometriotic lesions) should be performed rather than only diagnostic laparoscopy, to increase ongoing pregnancy rates. Also, for infertile women with stage I/II endometriosis doctors may consider complete surgical removal of endometriosis to improve live birth rate prior to assisted reproductive treatment. This last recommendation is not well established...
January 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29046194/the-role-of-intravenous-access-during-oral-food-challenges-in-food-protein-induced-enterocolitis-syndrome
#15
Laura E Pena, Danielle Guffey, Charles G Minard, Sara Anvari, Carla M Davis
BACKGROUND: Food protein-induced enterocolitis syndrome (FPIES) is a non-immunoglobulin E mediated food hypersensitivity syndrome characterized by profuse vomiting and diarrhea, which leads to lethargy, dehydration, and hypotension. Given the potential severity of reactions, resolution of FPIES is confirmed via oral food challenge (OFC) during which intravenous (IV) access is recommended to facilitate IV fluids (IVF) and steroid therapy. Risk factors for IV treatment are not well characterized...
November 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28965552/development-of-in-vitro-maturation-techniques-for-clinical-applications
#16
REVIEW
Zhi-Yong Yang, Ri-Cheng Chian
In vitro maturation (IVM) refers to maturation in culture of immature oocytes at different stages that may or may not have been exposed to short courses of gonadotropins. The source of immature oocytes is an important feature for subsequent embryonic development, pregnancy, and healthy live births. IVM is an effective treatment that has already achieved significant outcomes of acceptable pregnancy and implantation rates and has led to the births of several thousand healthy babies. As the development of IVM treatment continues, an attractive possibility for improving the already successful outcome is to combine a natural-cycle in vitro fertilization (IVF) treatment with immature-oocyte retrieval followed by IVM of those immature oocytes...
October 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28965550/in-vitro-fertilization-treatments-with-the-use-of-clomiphene-citrate-or-letrozole
#17
REVIEW
Jigal Haas, Robert F Casper
There has been increasing interest in combining the oral agents clomiphene citrate (CC) and letrozole with gonadotropins in IVF: for poor responders to reduce the amount of gonadotropins used, and in normal responders to reduce the incidence of ovarian hyperstimulation (OHSS). In normal responders, mild stimulation with the use of CC and gonadotropins was found to decrease the number of oocytes retrieved and result in good pregnancy rates, but in most studies the cumulative pregnancy rate was lower compared with conventional ovarian stimulation when frozen embryo transfers were considered...
October 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28965549/mild-stimulation-for-in-vitro-fertilization
#18
REVIEW
Geeta Nargund, Adrija Kumar Datta, Bart C J M Fauser
It has been proven that the use of high gonadotropin dose does not necessarily improve the final outcome of IVF. Mild ovarian stimulation is based on the principle of optimal utilization of competent oocytes/embryos and endometrial receptivity. There is growing evidence that the pregnancy or live birth rates with mild-stimulation protocols are comparable to those with conventional IVF; the cumulative pregnancy outcome has been shown to be no different, despite having fewer numbers of oocytes or embryos available with milder ovarian stimulation...
October 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28948397/neonatal-outcomes-and-congenital-malformations-in-children-born-after-human-menopausal-gonadotropin-and-medroxyprogesterone-acetate-treatment-cycles
#19
Jie Zhang, Xiaoyan Mao, Yun Wang, Qiuju Chen, Xuefeng Lu, Qingqing Hong, Yanping Kuang
PURPOSE: To investigate neonatal outcomes and congenital malformations in children born after in vitro fertilization (IVF) and vitrified embryo transfer cycles using human menopausal gonadotrophin and medroxyprogesterone acetate (hMG + MPA) treatment. METHODS: We performed a retrospective cohort study including 4596 live born babies. During January 2014-June 2016, children born after either hMG + MPA treatment, gonadotropin releasing hormone agonist short protocol, or mild ovarian stimulation were included...
December 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28911928/introduction-contemporary-approaches-to-alternative-ovarian-stimulation-strategies-for-in-vitro-fertilization
#20
Richard J Paulson
In the current practice of IVF, the vast majority of cycles use some form of controlled ovarian stimulation before egg retrieval to increase the number of embryos available for transfer or cryopreservation. However, the optimal stimulation regimen has not been established. This month's Views and Reviews presents five different approaches to alternative ovarian stimulation strategies. These include mild stimulation regimens, modified natural cycles, stimulation with oral agents, in vitro maturation (in the absence of stimulation), and finally, a proposal for patient-tailored ovarian stimulation...
October 2017: Fertility and Sterility
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