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https://www.readbyqxmd.com/read/29777258/development-of-a-two-stage-in-vitro-model-system-to-investigate-the-mineralization-mechanisms-involved-in-idiopathic-stone-formation-stage-1-biomimetic-randall-s-plaque-using-decellularized-porcine-kidneys
#1
Archana C Lovett, Saeed R Khan, Laurie B Gower
Idiopathic calcium oxalate (CaOx) stone formers form stones that are commonly attached to calcium phosphate (CaP) deposits in the renal tissue, known as Randall's plaques (RP). Plaques are suggested to originate in the renal tubular basement membrane, where they exhibit a morphology of concentrically laminated apatitic spherules, while in the interstitial regions, the collagen fibrils and vesicles become mineralized. We hypothesize that these minerals might form by non-classical crystallization mechanisms, such as via amorphous precursors, some of which might originate from a polymer-induced liquid-precursor (PILP) process...
May 18, 2018: Urolithiasis
https://www.readbyqxmd.com/read/29775451/-recurrent-urolithiasis-as-a-symptom-of-primary-hyperparathyroidism-in-a-16-year-old-boy
#2
Monika Wojciechowska, Beata Bieniaś, Aleksandra Sobieszczańska-Droździel, Anna Wieczorkiewicz-Płaza, Iwona Beń-Skowronek, Przemysław Sikora
Primary hyperparathyroidism is one of the most common endocrine diseases, however, it is rare in children. In most cases, it is caused by adenoma of these organs. Its most common complications include urolithiasis, nephrocalcinosis and osteoporosis. CASE REPORT: A 16-year-old patient was admitted to our Clinic because of his first-ever renal colic. The ultrasound examination revealed rightsided hydronephrosis caused by the presence of 9 mm stone in the upper part of the right ureter. In addition, the presence of 8 mm stone in the middle calyx of the left kidney was found...
April 23, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29774824/technique-of-percutaneous-nephrolithotomy
#3
Ahmed Ibrahim, Daniel Wollin, Glenn Preminger, Sero Andonian
According to the latest American and European Urological Association guidelines, percutaneous nephrolithotomy (PNL) is the current gold standard treatment for patients presenting with symptomatic large or complex renal stones ≥2 cm. This review chapter and accompanying videos will review the latest literature on indications, preoperative preparations, different patient positions, in addition to step by step explanations for the technique of PNL. Postoperative care and troubleshooting tips are provided. Furthermore, latest reported outcomes are reviewed...
May 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29774807/robotic-pyelolithotomy-extended-pyelolithotomy-nephrolithotomy-and-anatrophic-nephrolithotomy
#4
Rabii Madi, Ashok Hemal
INTRODUCTION: We are a reporting on the indications, techniques, and limitations of robotic surgery in the management of renal stones disease. Robotic surgery is a good tool to manage large kidney and ureteral stones, particularly in patients with anatomic anomalies. We describe three techniques in managing staghorn kidney stones: robotic anatrophic nephrolithotomy, robotic pyelolithotomy, and robotic nephrolithotomy. MATERIAL AND METHODS: Robotic pyelolithotomy (RP) is ideal for patients with large renal pelvis and partial staghorn stone with a wide extra-renal pelvis...
May 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29772936/the-effect-of-supine-positioning-on-maternal-hemodynamics-during-late-pregnancy
#5
Aimee Humphries, S Ali Mirjalili, Gregory P Tarr, John M D Thompson, Peter Stone
INTRODUCTION: Recent studies have demonstrated an association between maternal supine sleep position and an increased risk of late stillbirth. During late pregnancy the gravid uterus compresses the inferior vena cava when a woman lies in the supine position. The azygos system of veins is the dominant pathway of collateral venous return back to the heart in the event of acute obstruction of the inferior vena cava. It is suggested that this pathway provides adequate collateral venous circulation in the event of inferior vena caval compression in the supine position during late pregnancy...
May 17, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29761689/percutaneous-nephrolithotomy-in-solitary-kidneys-effective-safe-and-improves-renal-functions
#6
Volkan Caglayan, Sedat Oner, Efe Onen, Sinan Avci, Murat Aydos, Metin Kilic, Murat Demirbas
BACKGROUND: To evaluate success and complication rates of endourological stone treatments and to evaluate effects of percutaneous nephrolithotomy (PCNL) on renal functions, in patients with solitary kidneys. METHODS: In our center, 3150 patients underwent PCNL between 2003 and 2017 and 142 patients underwent retrograd intrarenal surgery (RIRS) between 2013 and 2017. We retrospectively analysed the data of 82 patients with solitary kidney who underwent PCNL and of 8 patients with solitary kidney who underwent RIRS...
May 14, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29761687/emergency-extracorporeal-shockwave-lithotripsy-eswl-as-opposed-to-delayed-swl-dswl-for-the-treatment-of-acute-renal-colic-due-to-obstructive-ureteral-stone-a-prospective-randomized-trial
#7
Stefano Bucci, Paolo Umari, Michele Rizzo, Nicola Pavan, Giovanni Liguori, Fabio Barbone, Carlo Trombetta
BACKGROUND: To assess the efficacy of emergency extracorporeal shockwave lithotripsy (eSWL) as first-line treatment in patients with acute colic due to obstructive ureteral stone. METHODS: 74 patients were randomized to emergency SWL within 12 hours (eSWL group) and deferred SWL later than 3 days (dSWL group). Follow-up included ultrasound, KUB (Kidney-Ureter-Bladder) radiography and CT (computed tomography) scan at 24 hours, 7 days, 1 and 3 months from the treatment...
May 14, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29761242/safety-and-efficacy-of-benzbromarone-and-febuxostat-in-hyperuricemia-patients-with-chronic-kidney-disease-a-prospective-pilot-study
#8
Haibo Yu, Xinying Liu, Yaxiang Song, Jiafen Cheng, Hui Bao, Ling Qin, Xuan Zhou, Ling Wang, Ai Peng
BACKGROUND: To compare the safety and efficacy of benzbromarone and febuxostat in hyperuricemia patients with estimated glomerular filtration rate (eGFR) 20-60 mL/min/1.73 m2 . METHODS: This study was a single-centered, parallel-grouped, randomized clinical trial (RCT). We randomly assigned hyperuricemia participants with eGFR 20-60 mL/min/1.73 m2 into benzbromarone and febuxostat treatment group. Drugs were adjusted by titration from small doses. RESULTS: Seventy-three eligible participants enrolled, 66 subjects (33 in each group) were included finally for analysis...
May 14, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29761227/outcome-of-flexible-ureteroscopy-for-renal-stone-with-overnight-ureteral-catheterization-a-propensity-score-matching-analysis
#9
Mitsuru Komeya, Kimitsugu Usui, Takuo Asai, Takehiko Ogawa, Masataka Taguri, Koshi Kataoka, Masahiro Yao, Junichi Matsuzaki
PURPOSE: To evaluate the influence of overnight ureteral catheterization and determine if routine long-term post-stenting can be avoided in flexible ureterorenoscopy (fURS) procedure for kidney stone. METHODS: Three hundred ninety-three patients who underwent single fURS for kidney stone between January 2013 and June 2016 at a single institute were retrospectively analyzed. The stone-free (SF) and perioperative complication rates in patients with routine long-term post-stenting after fURS (long-term stent group) were compared with those of patients with overnight ureteral catheterization (short-term stent group)...
May 14, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29761226/renal-stone-composition-does-not-affect-the-outcome-of-percutaneous-nephrolithotomy-in-children
#10
Onur Kaygısız, Fethi Ahmet Türegün, Nihat Satar, Ender Özen, Serdar Toksöz, Hasan Serkan Doğan, Mehmet Mesut Pişkin, Volkan İzol, Şaban Sarıkaya, Hakan Kılıçarslan, Tufan Çiçek, Ahmet Öztürk, Serdar Tekgül, Bülent Önal
PURPOSE: We sought to investigate the association between renal stone composition and percutaneous nephrolithotomy outcomes in pediatric patients and define the characterization of the stone composition. METHODS: The data of 1157 children who underwent percutaneous nephrolithotomy between 1991 and 2012 were retrieved from the multicenter database of the Turkish Pediatric Urology Society. The study population comprised 359 children (160 girls, 199 boys) with stone analyses...
May 14, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29760156/improved-survival-with-renal-transplantation-for-end-stage-renal-disease-due-to-granulomatosis-with-polyangiitis-data-from-the-united-states-renal-data-system
#11
Zachary S Wallace, Rachel Wallwork, Yuqing Zhang, Na Lu, Frank Cortazar, John L Niles, Eliot Heher, John H Stone, Hyon K Choi
BACKGROUND: Renal transplantation is the optimal treatment for selected patients with end-stage renal disease (ESRD). However, the survival benefit of renal transplantation among patients with ESRD attributed to granulomatosis with polyangiitis (GPA) is unknown. METHODS: We identified patients from the United States Renal Data System with ESRD due to GPA (ESRD-GPA) between 1995 and 2014. We restricted our analysis to waitlisted subjects to evaluate the impact of transplantation on mortality...
May 14, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29753848/outcomes-of-conservative-management-of-asymptomatic-live-donor-kidney-stones
#12
Mehmet Sarier, Ibrahim Duman, Mehmet Callioglu, Ahmet Soylu, Sabri Tekin, Emrah Celep, Hasan Turan, Asuman Havva Yavuz, Alper Demirbas, Erdal Kukul
OBJECTIVES: To evaluate the long-term outcomes of asymptomatic stones ≤4 mm which are left in situ during renal transplantation (RT). METHODS: Between 2009 and 2017, 31 patients who received stone-bearing (≤4 mm) kidneys were analyzed. At their last follow-up, the patients were evaluated with CT imaging and the results were compared to the initial CT findings obtained during donor evaluation. RESULTS: The mean stone size was 2.9mm (range 1-4...
May 10, 2018: Urology
https://www.readbyqxmd.com/read/29750814/one-year-mortality-after-recovery-from-critical-illness-a-retrospective-cohort-study
#13
Sharukh Lokhandwala, Ned McCague, Abdullah Chahin, Braiam Escobar, Mengling Feng, Mohammad M Ghassemi, David J Stone, Leo Anthony Celi
RATIONALE: Factors associated with one-year mortality after recovery from critical illness are not well understood. Clinicians generally lack information regarding post-hospital discharge outcomes of patients from the intensive care unit, which may be important when counseling patients and families. OBJECTIVE: We sought to determine which factors among patients who survived for at least 30 days post-ICU admission are associated with one-year mortality. METHODS: Single-center, longitudinal retrospective cohort study of all ICU patients admitted to a tertiary-care academic medical center from 2001-2012 who survived ≥30 days from ICU admission...
2018: PloS One
https://www.readbyqxmd.com/read/29750296/hyperoside-protects-human-kidney%C3%A2-2-cells-against-oxidative-damage-induced-by-oxalic-acid
#14
Yongliang Chen, Lihong Ye, Wangjian Li, Dongzhang Li, Feng Li
The majority of renal calculi (kidney stones) are calcium stones. Oxidative damage to renal tubular epithelial cells induced by reactive oxygen species (ROS) is the predominant cause of calcium oxalate stone formation. Hyperoside (Hyp) is a flavonol glycoside extracted from medicinal plants and appears to exhibit potent antioxidant activity in various cells. The aim of the present study was to investigate the protective effect of Hyp on renal cells exposed to oxidative stress simulated by oxalic acid (OA), and to determine whether the underlying mechanism involves the nuclear factor E2‑related factor2 (Nrf2)‑antioxidative response element signaling pathway...
May 2, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29747780/comparison-of-miniaturized-percutaneous-nephrolithotomy-and-flexible-ureterorenoscopy-for-moderate-size-renal-stones-in-elderly-patients
#15
Faruk Ozgor, Fatih Yanaral, Metin Savun, Harun Ozdemir, Ufuk Caglar, Omer Sarilar
Life expectancy has become longer, thus the number of elderly people who require treatment for nephrolithiasis has increased. We aimed to analyze the efficacy of flexible ureterorenoscopy (f-URS) and miniaturized percutaneous nephrolithotomy (mPNL) in the management of 10 and 30 mm renal stones in patients aged >60 years. In prospective non-randomized series, the data of patients who underwent f-URS or mPNL for kidney stones between July 2013 and July 2016 were analyzed. The procedure was accepted as successful if the patient was achieved complete stone clearance according to CT imaging between 1-3 months postoperatively...
June 2018: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29746311/evaluating-mortality-risk-adjustment-among-children-receiving-extracorporeal-support-for-respiratory-failure
#16
Ryan P Barbaro, Philip S Boonstra, Kevin W Kuo, David T Selewski, David K Bailly, Cheryl L Stone, Chin Ying Chow, Gail M Annich, Frank W Moler, Matthew L Paden
This study evaluates whether three commonly used pediatric intensive care unit (PICU) severity of illness scores, pediatric risk of mortality score (PRISM) III, pediatric index of mortality (PIM) 2, and pediatric logistic organ dysfunction (PELOD), are the appropriate tools to discriminate mortality risk in children receiving extracorporeal membrane oxygenation (ECMO) support for respiratory failure. This study also evaluates the ability of the Pediatric Risk Estimate Score for Children Using Extracorporeal Respiratory Support (Ped-RESCUERS) to discriminate mortality risk in the same population, and whether Ped-RESCUERS' discrimination of mortality is improved by additional clinical and laboratory measures of renal, hepatic, neurologic, and hematologic dysfunction...
May 8, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29745818/novel-insights-into-renal-mineralization-and-stone-formation-through-advanced-imaging-modalities
#17
Scott V Wiener, Ling Chen, Alex R Shimotake, Misun Kang, Marshall L Stoller, Sunita P Ho
Purpose/Aim: The most common kidney stone composed of calcium oxalate forms on interstitial calcium phosphate mineral known as a Randall's plaque (RP). Due to limited information about events leading to the initial deposition of nanometer size interstitial calcium phosphate pre-clusters, there continues to be a debate on the initial site of calcium phosphate deposition and factors leading to stone formation. MATERIALS AND METHODS: High-resolution X-ray micro-computed tomography (CT), and light and electron microscopy techniques were used to characterize human renal pyramids and five representative kidney stones with identifiable stems...
December 2018: Connective Tissue Research
https://www.readbyqxmd.com/read/29738031/influence-of-nutritional-status-laboratory-parameters-and-dietary-patterns-upon-urinary-acid-excretion-in-calcium-stone-formers
#18
Carolini Zanette Warmling Tessaro, Christiane Ishikawa Ramos, Ita Pfeferman Heilberg
INTRODUCTION: Obesity and Metabolic Syndrome (MS) are associated with low urinary pH and represent risk factors for nephrolithiasis, especially composed by uric acid. Acidogenic diets may also contribute to a reduction of urinary pH. Propensity for calcium oxalate precipitation has been shown to be higher with increasing features of the MS. OBJECTIVE: A retrospective evaluation of anthropometric and body composition parameters, MS criteria and the dietary patterns of overweight and obese calcium stone formers and their impact upon urinary pH and other lithogenic parameters was performed...
April 26, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29738008/does-fasting-in-ramadan-increase-the-risk-of-developing-urinary-stones
#19
Abdullah O Al Mahayni, Sultan S Alkhateeb, Ibrahim H Abusaq, Abdullah A Al Mufarrih, Muath I Jaafari, Amen A Bawazir
OBJECTIVES: To explore the frequency of renal colic (RC) secondary to urinary stones in Ramadan compared to other months and seasons of the year. METHODS: Retrospective cross-sectional study using medical records of 237 patients admitted through the emergency room (ER) with a diagnosis of RC secondary to urinary stones over a 10-year period at King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia. RESULTS: Patients fasting in Ramadan are 2 times more likely to present with a calculus of ureter as opposed to calculus in another location in the urinary tract, particularly when the holy month of Ramadan falls in the summer season...
May 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29737501/safety-of-tamsulosin-a-systematic-review-of-randomized-trials-with-a-focus-on-women-and-children
#20
REVIEW
Steven A Kaplan, Bilal I Chughtai
INTRODUCTION: Although tamsulosin is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH), it has also been assessed in clinical studies for other conditions/symptoms and in other populations such as women and children. In this systematic review of randomized studies, the overall safety of tamsulosin was assessed, focusing on these understudied populations. METHODS: Literature searches were conducted using Embase, Medline, and PubMed (inception-December 2015)...
May 8, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
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