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Suchada Manoka, Bunleu Sungthong, Hitoshi Sato, Erika Sugiyama, Vilasinee Hirunpanich Sato
Antidiabetic effect of the water extract of Aquilaria crassna (A. crassna) leaves was recently claimed by some diabetic patients in Thailand, whereas its experimental evidence has not been published yet. The present study was therefore conducted to investigate pharmacological activities of the water extract of A. crassna leaves, focusing on its antioxidative and hypoglycemic effects in vitro and in vivo using streptozotocin (STZ)-nicotinamide (NA)-induced type 2 diabetic (DM) mice. An antioxidant activity of the herb extract was confirmed using a 2,2-diphenyl-1-picrylhydrazyl hydrate (DPPH) radical scavenging assay, and its IC50 on DPPH inhibition was determined to be 34...
June 2016: Natural Product Communications
Hong-Ni Wang, Wen-Hua Dong, Sheng-Zhuo Huang, Wei Li, Fan-Dong Kong, Hao Wang, Jun Wang, Wen-Li Mei, Hao-Fu Dai
Three new sesquiterpenoids (1-3), together with two known ones were isolated from the EtOAc extract of agarwood originating from Aquilaria crassna. The new compounds were elucidated on the basis of spectroscopic techniques (UV, IR, MS, 1D and 2D NMR). Compounds 1-5 were isolated from agarwood of A. crassna for the first time. In the acetylcholinesterase inhibition experiment of 2-5, compound 3 showed acetylcholinesterase inhibition activity (IR 42.9±0.6%). Compound 5 expressed antibacterial activities against Staphylococcus aureus and Ralstonia solanacearum with diameter of the inhibition zones of 12...
October 2016: Fitoterapia
Saad Sabbar Dahham, Loiy E Ahmed Hassan, Mohamed B Khadeer Ahamed, Aman Shah Abdul Majid, Amin Malik Shah Abdul Majid, Nik Noriman Zulkepli
BACKGROUND: Aquilaria crassna has been used in traditional Asian medicine to treat vomiting, rheumatism, asthma, and cough. Furthermore, earlier studies from our laboratory have revealed that the essential oil extract from agarwood inhibited colorectal carcinoma cells. Despite of the wide range of ethno-pharmacological uses of agarwood, its toxicity has not been previously evaluated through systematic toxicological studies. Therefore, the potential safety of essential oil extract and its in vivo anti-tumor activity had been investigated...
2016: BMC Complementary and Alternative Medicine
Jinling Yang, Wenhua Dong, Fandong Kong, Ge Liao, Jun Wang, Wei Li, Wenli Mei, Haofu Dai
A total of fifty-six chromones, including seven 5,6,7,8-tetrahydro-2-(2-phenylethyl)-chromones (THPECs), five 5,6-epoxy-2-(2-phenylethyl)chromones (EPECs), seven 5,6:7,8-diepoxy-2-(2-phenylethyl)chromones (DEPECs) and thirty-seven 2-(2-phenylethyl)chromones of the flidersia type (FTPECs), were characterized by HPLC/DAD/ESI/MS/MS in three agarwood samples (from Aquilaria crassna) induced by artificial holing with different holing times. The characteristic fragmentation behavior of DEPECs and EPECs, and the methods to distinguish these four types of chromones by MS analysis were described for the first time...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Airi Suzuki, Katsunori Miyake, Yohei Saito, Faradiba Abdul Rasyid, Harukuni Tokuda, Misa Takeuchi, Nobutaka Suzuki, Eiichiro Ichiishi, Tetsuo Fujie, Masuo Goto, Yohei Sasaki, Kyoko Nakagawa-Goto
A new chromone, 2-(2-hydroxy-2-phenylethyl)chromone (1), was isolated together with ten known phenylethyl chromones from MeOH extracts of agarwood (Aquilaria filaria). The selected compounds were evaluated in an antiproliferative assay against five human tumor cell lines, including a multidrug-resistant cell line. They were also tested for antitumor promoting activity, as mediated by 12-O-tetradecanoylphorbol-13-acetate-induced activation of the Epstein-Barr virus early antigen in Raji cells. Among all compounds, 4',7-dimethyoxy-6-hydroxychromone (2) displayed broad spectrum antiproliferative activity against all tumor cell lines tested with IC50 values of 25-38 µM, while 8 was selectively inhibitory against multidrug-resistant cells...
July 8, 2016: Planta Medica
Hang Shao, Wen-Li Mei, Fan-Dong Kong, Wen-Hua Dong, Wei Li, Guo-Peng Zhu, Hao-Fu Dai
A new 2-(2-phenylethyl)chromone glycoside, 2-[2-(4-glucosyloxy-3-methoxyphenyl)ethyl]chromone (1), was isolated from the high-quality Chinese agarwood "Qi-Nan" originating from Aquilaria sinensis (Lour.) Glig. The structure including the absolute configuration of the sugar moiety was elucidated by spectroscopic techniques (UV, IR, 1D and 2D NMR), MS analysis, PMP-labeling HPLC analysis methods, as well as comparison with literature data. To the best of our knowledge, it is the first time that chromone glycoside was discovered in agarwood, or even in the whole Aquilaria plants...
June 29, 2016: Journal of Asian Natural Products Research
Yumi Zuhanis Has-Yun Hashim, Philip G Kerr, Phirdaous Abbas, Hamzah Mohd Salleh
ETHNOPHARMACOLOGICAL RELEVANCE: Aquilaria spp. (agarwood) has been a part of Ayurvedic and Traditional Chinese Medicine for centuries. Agarwood has also been used as a traditional medicine in Southeast Asian countries, Bangladesh and Tibet. Its common uses include the treatment of joint pain, inflammatory-related ailments, and diarrhoea, as well as a stimulant, sedative and cardioprotective agent. In this paper, we aim to provide an overview of the phytochemistry, ethnomedicinal use, pharmacological activities and safety of plant materials from Aquilaria spp...
August 2, 2016: Journal of Ethnopharmacology
De-Lan Yang, Wei Li, Wen-Hua Dong, Jun Wang, Wen-Li Mei, Hao-Fu Dai
No abstract text is available yet for this article.
July 2016: Fitoterapia
Xiaohui Wang, Bowen Gao, Xiao Liu, Xianjuan Dong, Zhongxiu Zhang, Huiyan Fan, Le Zhang, Juan Wang, Shepo Shi, Pengfei Tu
BACKGROUND: Agarwood, is a resinous portion derived from Aquilaria sinensis, has been widely used in traditional medicine and incense. 2-(2-phenylethyl)chromones are principal components responsible for the quality of agarwood. However, the molecular basis of 2-(2-phenylethyl)chromones biosynthesis and regulation remains almost unknown. Our research indicated that salt stress induced production of several of 2-(2-phenylethyl)chromones in A. sinensis calli. Transcriptome analysis of A...
2016: BMC Plant Biology
Yuanbin Li, Nan Sheng, Lingli Wang, Shijie Li, Jiannan Chen, Xiaoping Lai
Agarwood is the fragrant resinous material mainly formed from species of Aquilaria. 2-(2-phenylethyl)chromones, especially the highly oxidized 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones, are the main representative compounds from agarwood. It is important to determine whether agarwood in trade is from cultivated trees or natural trees in the Convention on the International Trade in Endangered Species (CITES). We characterized the 2-(2-phenylethyl)chromones in agarwood by ultra-performance liquid chromatography coupled with electrospray ionization mass spectrometry (UPLC-ESI-QTOF-MS) and differentiated wild from cultivated agarwood by metabolomic analysis...
2016: International Journal of Molecular Sciences
Wei Ye, Hongqing Wu, Xin He, Lei Wang, Weimin Zhang, Haohua Li, Yunfei Fan, Guohui Tan, Taomei Liu, Xiaoxia Gao
BACKGROUND: Agarwood is a traditional Chinese medicine used as a clinical sedative, carminative, and antiemetic drug. Agarwood is formed in Aquilaria sinensis when A. sinensis trees are threatened by external physical, chemical injury or endophytic fungal irritation. However, the mechanism of agarwood formation via chemical induction remains unclear. In this study, we characterized the transcriptome of different parts of a chemically induced A. sinensis trunk sample with agarwood. The Illumina sequencing platform was used to identify the genes involved in agarwood formation...
2016: PloS One
Yukie Kumeta, Michiho Ito
The resinous portions of Aquilaria and Gyrinops plants are known as 'agarwood' and have a distinctive fragrance. To examine the biosynthesis of these fragrant compounds, we previously established cell cultures of Aquilaria crassna in which the production of three sesquiterpenes (α-guaiene, α-humulene, and δ-guaiene) could be induced by methyl jasmonate (MJ), and showed that cloned δ-guaiene synthase from MJ-treated cells is involved in the synthesis of these three compounds, although only very small amounts of α-humulene are produced...
July 2016: Journal of Natural Medicines
Th Babita Devi, Shamima Begum, M Ahmaruzzaman
This study reports a green process for the fabrication of Ag@AgCl (silver@silver chloride) nanoparticles by using Aquilaria agallocha (AA) leaves juice without using any external reagents. The effect of various reaction parameters, such as reaction temperature, reaction time and concentration of Aquilaria agallocha leaves juice in the formation of nanoparticles have also been investigated. From the FTIR spectra of leaves juice and phytochemicals test, it was found that flavonoids present in the leaves are responsible for the reduction of Ag(+) ions to Ag(0) species and leads to the formation of Ag@AgCl NPs...
July 2016: Journal of Photochemistry and Photobiology. B, Biology
Zhongxiu Zhang, Xiaohui Wang, Wanqing Yang, Juan Wang, Cong Su, Xiao Liu, Jun Li, Yunfang Zhao, Shepo Shi, Pengfei Tu
Five 2-(2-phenylethyl)chromones including a new one, (5S,6R,7S,8R)-5,8-dichloro-6,7-dihydroxy-2-phenylethyl-5,6,7,8-tetrahydro-4H-chromen-4-one (1), and four known ones (2-5), were isolated from 150 mM NaCl-elicited Aquilaria sinensis cell suspension cultures. In addition, three feruloyl amides (6-8), six nucleosides (9-14), (+)-syringaresinol (15), indole-3-carboxaldehyde (16), and two glycosides (17-18) were also obtained. The structures were unambiguously identified by analysis of their UV, IR, NMR, and HRESIMS data...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Shiou Yih Lee, Wei Lun Ng, Mohd Noor Mahat, Mohd Nazre, Rozi Mohamed
The identification of Aquilaria species from their resinous non-wood product, the agarwood, is challenging as conventional techniques alone are unable to ascertain the species origin. Aquilaria is a highly protected species due to the excessive exploitation of its precious agarwood. Here, we applied the DNA barcoding technique to generate barcode sequences for Aquilaria species and later applied the barcodes to identify the source species of agarwood found in the market. We developed a reference DNA barcode library using eight candidate barcode loci (matK, rbcL, rpoB, rpoC1, psbA-trnH, trnL-trnF, ITS, and ITS2) amplified from 24 leaf accessions of seven Aquilaria species obtained from living trees...
2016: PloS One
Ying Wang, Di-Feng Zhan, Xian Jia, Wen-Li Mei, Hao-Fu Dai, Xiong-Ting Chen, Shi-Qing Peng
Aquilaria sinensis (Lour.) Gilg is an important medicinal woody plant producing agarwood, which is widely used in traditional Chinese medicine. High-throughput sequencing of chloroplast (cp) genomes enhanced the understanding about evolutionary relationships within plant families. In this study, we determined the complete cp genome sequences for A. sinensis. The size of the A. sinensis cp genome was 159,565 bp. This genome included a large single-copy region of 87,482 bp, a small single-copy region of 19,857 bp, and a pair of inverted repeats (IRa and IRb) of 26,113 bp each...
2016: Frontiers in Plant Science
Michal Korinek, Vitthal D Wagh, I-Wen Lo, Yu-Ming Hsu, Hsue-Yin Hsu, Tsong-Long Hwang, Yang-Chang Wu, Yuan-Bin Cheng, Bing-Hung Chen, Fang-Rong Chang
The Aquilaria malaccensis (Thymelaeaceae) tree is a source of precious fragrant resin, called agarwood, which is widely used in traditional medicines in East Asia against diseases such as asthma. In our continuous search for active natural products, A. malaccensis seeds ethanolic extract demonstrated antiallergic effect with an IC50 value less than 1 µg/mL. Therefore, the present research aimed to purify and identify the antiallergic principle of A. malaccensis through a bioactivity-guided fractionation approach...
2016: International Journal of Molecular Sciences
Huan Zhao, Qinghua Peng, Zhuzhen Han, Li Yang, Zhengtao Wang
Three new sesquiterpenoids (1-3) and one new sesquiterpenoid derivative (4), along with three known sesquiterpenoids (5-7), were isolated from the 95% ethanolic extract of Chinese eaglewood [Aquilaria sinensis (Lour.) Gilg]. The structures of these compounds were elucidated through extensive analysis of spectroscopic data including IR, NMR, HRESIMS, and X-ray diffraction experiments. In addition, the above new compounds were detected for their bioactivities against LPS-induced NO production in RAW 264.7 cells...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Wei Li, Ge Liao, Wen-Hua Dong, Fan-Dong Kong, Pei Wang, Hao Wang, Wen-Li Mei, Hao-Fu Dai
Two new sesquiterpenoids, 3-oxo-7-hydroxylholosericin A (1) and 1,5;8,12-diepoxy-guaia-12-one (2), together with seven known sesquiterpenoids 3-9, were isolated from Chinese agarwood induced by artificial holing originating from Aquilaria sinensis (Lour.) Gilg. Their structures were identified by spectroscopic techniques (UV, IR, 1D and 2D NMR) and MS analyses. The absolute configuration of compound 1 was determined by comparison of its measured CD curve with that of calculated data for 1 and ent-1. The NMR data of 3 were reported in this study for the first time...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Yan-Hong Xu, Yong-Cui Liao, Zheng Zhang, Juan Liu, Pei-Wen Sun, Zhi-Hui Gao, Chun Sui, Jian-He Wei
Agarwood, a highly valuable resinous and fragrant heartwood of Aquilaria plants, is widely used in traditional medicines, incense and perfume. Only when Aquilaria trees are wounded by external stimuli do they form agarwood sesquiterpene defensive compounds. Therefore, understanding the signaling pathway of wound-induced agarwood formation is important. Jasmonic acid (JA) is a well-characterized molecule that mediates a plant's defense response and secondary metabolism. However, little is known about the function of endogenous JA in agarwood sesquiterpene biosynthesis...
2016: Scientific Reports
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