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Bennet's lesion

Patrick van Eijk, Yumin Teng, Mark R Bennet, Katie E Evans, James R Powell, Richard M Webster, Simon H Reed
The genetic information contained within the DNA molecule is highly susceptible to chemical and physical insult, caused by both endogenous and exogenous sources that can generate in the order of thousands of lesions a day in each of our cells (Lindahl, Nature 362(6422):709-715, 1993). DNA damages interfere with DNA metabolic processes such as transcription and replication and can be potent inhibitors of cell division and gene expression. To combat these regular threats to genome stability, a host of DNA repair mechanisms have evolved...
2018: Methods in Molecular Biology
Mony Benifla, Odeya Bennet-Back, Zamir Shorer, Iris Noyman, Rima Bar-Yosef, Dana Ekstein
PURPOSE: Resection of the hippocampus can cause verbal memory decline, especially in the pediatric population. Thus, preservation of the hippocampus can be crucial for the quality of life of children with intractable temporal lobe epilepsy (TLE) who are candidates for epilepsy surgery. We investigated techniques that determine whether the hippocampus is part of the epileptogenic zone and the outcomes of pediatric surgery aimed to spare the hippocampus. METHODS: We accessed data of children with normal hippocampus on MRI, who underwent surgery for medically refractory TLE...
October 2, 2017: Seizure: the Journal of the British Epilepsy Association
Avita Rath, Priyadarshini H Ramamurthy, Bennete Aloysius Fernandes, Preena Sidhu
Tooth surface loss (TSL) is a complex phenomenon characterized by the loss of hard tooth structure at various locations of the teeth, usually due to more than one factor. TSL due to abrasion can be significant in patients consuming coarse, abrasive diet. The present case reports an interesting incisal edge abrasion in a female patient, attributed to a particular dietary behavior of long-term consumption of sunflower seeds. All her family members and most of the people from her native place were also reported to have similar lesions by the patient...
March 2017: Journal of Conservative Dentistry: JCD
Siyi Chen, Laura Bennet, Ailsa L McGregor
BACKGROUND: Pharmacological activation of the cholinergic anti-inflammatory pathway (CAP), specifically by activating α7 nicotinic acetylcholine receptors, has been shown to confer short-term improvements in outcome. Most studies have investigated administration within 24 hours of stroke, and few have investigated drugs approved for use in human patients. We investigated whether delayed administration of varenicline, a high-affinity agonist at α7 nicotinic receptors and an established therapy for nicotine addiction, decreased brain inflammation and improved functional performance in a mouse model of experimental stroke...
August 7, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Carles Juan-Sallés, Liliana Sofía Martínez, Arely G Rosas-Rosas, Alberto Parás, Osvaldo Martínez, Alejandra Hernández, Michael M Garner
Subacute and chronic mountain sickness of humans and the related brisket disease of cattle are characterized by right-sided congestive heart failure in individuals living at high altitudes as a result of sustained hypoxic pulmonary hypertension. Adaptations to high altitude and disease resistance vary among species, breeds, and individuals. The authors conducted a retrospective survey of right-sided cardiac hypertrophy associated with pulmonary arterial hypertrophy or arteriosclerosis in zoo mammals housed at Africam Safari (Puebla, México), which is located at 2,100 m above sea level...
December 2015: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
Sam Mathai, Lindsea C Booth, Joanne O Davidson, Paul P Drury, Mhoyra Fraser, Ellen C Jensen, Sherly George, Andrew Naylor, Alistair J Gunn, Laura Bennet
Acute, high-dose exposure to endotoxin lipopolysaccharide (LPS) in preterm fetal sheep can trigger periventricular white matter lesions (PVL), in association with severe hypotension/hypoxemia and significant mortality. Intriguingly, however, chronic or repeated exposure to LPS can induce tachyphylaxis. We therefore tested the hypothesis that progressive, acute on chronic fetal infection would be associated with white matter injury with little fetal mortality. Chronically instrumented preterm (0.7 gestational age) fetal sheep were exposed to a continuous low-dose LPS infusion (100 ng over 24 h, followed by 250 ng/24 h for 96 h) or saline...
February 2013: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Jennifer J Liang, Ian Bissett, Matthew Kalady, Ana Bennet, James M Church
Colorectal cancer is an invasive neoplasm of the glandular epithelium of the colon and rectum that begins in a precursor lesion and expands to replace its lesion of origin. The majority of colorectal cancers arise from an adenoma, and the 'adenoma to carcinoma' pathway has been acknowledged for decades. More recently, another precursor lesion has been recognized: the serrated polyp. Serrated polyps are characterized by a sawtooth appearance of the crypt epithelium resulting from failure of apoptosis and a build-up of aging colonocytes...
May 2013: ANZ Journal of Surgery
S Bennet, P A McCann, I McFadyen
Pathological lesions of long bones increase the morbidity of many common cancers. The orthopedic management of metastatic skeletal lesions can be challenging. The ultimate aim is to provide patients with a painless, functional limb. We present a report of two cases were a novel minimally invasive long bone nailing technique has been utilized to achieve skeletal stability and alleviation of symptoms.
2011: Hand Surgery
Delphine Vezzosi, Caroline Capuani, Florence Loubes-Lacroix, Jacques Lagarrigue, Antoine Bennet, Marie Bernadette Delisle, Philippe Caron
CONTEXT: Primary sellar melanocytic tumors are extremely rare, and they can mimic hormonally inactive pituitary macroadenoma both clinically and radiologically. OBJECTIVES: The aim of this study was to describe a new case of primary sellar melanocytic tumor, and place it in the context of published literature. DESIGN: This is a case report. PATIENT: The case of a 61-year-old woman presenting with a 2-month history of fatigue and progressive bitemporal hemianopia is described...
2009: Pituitary
Mairi Steven, Nagarajan Kumaran, Robert Carachi, Ashish Desai, George Bennet
Haemangiomas and vascular malformations of the limb in children are often difficult to manage. The role of surgery and intervention in current management is still not clear. The aim of this study was to review our experience of such patients. Patients were identified using the health board database of inpatient admissions between 1999 and 2003. Clinical notes were reviewed and data collected looking at patient demographics, site of lesion, clinical findings, investigative procedures, intervention and follow-up...
June 2007: Pediatric Surgery International
Louise Bennet, Carl-Johan Fraenkel, Ulf Garpmo, Anders Halling, Mikael Ingman, Katharina Ornstein, Louise Stjernberg, Johan Berglund
AIM: The aim in this survey was to study the clinical characteristics of infections caused by Borrelia genospecies in patients with erythema migrans where borrelial origin was confirmed by polymerase chain reaction. The aim was also to study factors influencing the clinical appearance of erythema migrans. METHODS: The study was conducted in southern Sweden from May 2001 to December 2003 on patients 18 years and older attending with erythema migrans at outpatient clinics...
September 2006: Wiener Klinische Wochenschrift
Celia S Chen, Kerry D Phillips, Scott Grist, Graeme Bennet, Jamie E Craig, James S Muecke, Graeme K Suthers
BACKGROUND AND AIM: Congenital hypertrophy of the retinal pigment epithelium (CHRPE) is a pigmented fundus lesion associated with familial adenomatous polyposis (FAP). CHRPE prevalence has been reported to be increased in subjects with familial or sporadic non-polyposis colorectal cancer (CRC), suggesting that some individuals with non-polyposis CRC have an attenuated form of FAP. Other studies have not confirmed these clinical observations and have failed to identify mutations in the gene responsible for FAP, but the reason for the discrepancy in relation to CHRPE prevalence has not been resolved...
2006: Familial Cancer
Sara Jarefors, Louise Bennet, Elin You, Pia Forsberg, Christina Ekerfelt, Johan Berglund, Jan Ernerudh
Lyme borreliosis is a tick-borne disease often manifesting as a circular skin lesion. This cutaneous form of the disease is known as erythema migrans. In a 5-year follow-up study in southern Sweden, 31 of 708 individuals initially diagnosed with erythema migrans and treated with antibiotics were found to be reinfected with Borrelia burgdorferi. Although men and women were tick-bitten to the same extent, 27 of the 31 reinfected individuals were women, all of whom were over 44 years of age. The aim of this study was to determine whether this discrepancy in gender distribution could be a result of differences in immunological response...
June 2006: Immunology
J Guan, L Bennet, P D Gluckman, A J Gunn
It is now well established that neurons and other cell types may die many hours or even days after hypoxic-ischemic injury due to activation of programmed cell death (apoptotic) pathways. The potent anti-apoptotic factor IGF-1 and its binding proteins and receptors are intensely induced within damaged brain regions following brain injury suggesting a possible a role for IGF-1 in endogenous brain recovery. Exogenous administration of IGF-1 within a few hours after brain injury has now been shown to be protective in both grey and white matter, and leads to improved long-term neurological function...
2005: Endocrine Development
Xiaosong Wang, Massimiliano Ria, Peter M Kelmenson, Per Eriksson, David C Higgins, Ann Samnegård, Christina Petros, Jarod Rollins, Anna M Bennet, Björn Wiman, Ulf de Faire, Charlotte Wennberg, Per G Olsson, Naoto Ishii, Kazuo Sugamura, Anders Hamsten, Kristina Forsman-Semb, Jacob Lagercrantz, Beverly Paigen
Ath1 is a quantitative trait locus on mouse chromosome 1 that renders C57BL/6 mice susceptible and C3H/He mice resistant to diet-induced atherosclerosis. The quantitative trait locus region encompasses 11 known genes, including Tnfsf4 (also called Ox40l or Cd134l), which encodes OX40 ligand. Here we report that mice with targeted mutations of Tnfsf4 had significantly (P <or= 0.05) smaller atherosclerotic lesions than did control mice. In addition, mice overexpressing Tnfsf4 had significantly (P <or= 0...
April 2005: Nature Genetics
K Reddy, C Mallard, J Guan, K Marks, L Bennet, M Gunning, A Gunn, P Gluckman, C Williams
A characteristic of perinatal encephalopathies are the distinct patterns of neuronal and glial cell loss. Cerebral hypoperfusion is thought to be a major cause of these lesions. Gestational age is likely to influence outcome. This study compares the cortical electrophysiologic and histopathologic responses to hypoperfusion injury between preterm and near term fetuses. Chronically instrumented 0.65 (93-99-d, n = 9) and 0.9 (119-133-d, n = 6) gestation fetal sheep underwent 30 min of cerebral hypoperfusion injury...
May 1998: Pediatric Research
D W Stoller
This article explores MR arthrography of the glenohumeral joint, including normal anatomy of the glenoid labrum, glenohumeral ligaments, and biceps labral complex. Examples of glenohumeral joint instability include the Bankart lesion, anterior labroligamentous periosteal sleeve avulsion, glenolabral articular disruption, humeral avulsion of the glenohumeral ligament, and Bennet lesion. Normal variations include the sublabral foramen, the Buford complex, and cord-like middle glenohumeral ligament. Labral tears and paralabral cysts are also discussed...
January 1997: Radiologic Clinics of North America
M A Craigen, G C Bennet, J R MacKenzie, R Reid
We reviewed the records and radiographs of seven children who presented with knee pain, local tenderness over the medial femoral condyle, and radiological irregularity of the distal medial metaphysis of the femur suggestive of malignancy. In the five patients who had biopsies, histological changes were consistent with musculotendinous avulsion, and the dissection of ten cadavers confirmed the site to be the insertion of part of the adductor magnus. The recognition of this lesion and knowledge of its benign nature may avoid unnecessary anxiety and needless biopsy...
September 1994: Journal of Bone and Joint Surgery. British Volume
B Duerden, K W Bennet, J Faulkner
The introduction of an improved anaerobic system resulted in the isolation of Bacteroides ureolyticus (B corrodens) in numbers that suggested a pathogenic role from many more clinical specimens. During a three-year period B ureolyticus was isolated from 103 fairly superficial necrotic or gangrenous lesions all of which showed evidence of active infection. These included 27 perineal or genital infections, 15 perianal abscesses, 15 other soft tissue infections such as pilonidal abscesses and infected sebaceous cysts and 16 ulcers or gangrenous lesions of the lower limb...
March 1982: Journal of Clinical Pathology
G Lalande, C Diebler, A Grosvalet, G Ponsot, J M Bennet
Indications of CT examinations should be carefully established. Undisputed emergency indications in pediatric neurology are specified. Acute intracranial hypertension, whether isolated or associated with neurological signs or fever, is the principal emergency indication. Its main causes are posterior fossa tumors, but other space-occupying lesions may be found. The main radiological features in each etiology are described. Hemorrhage and trauma are the other essential emergency indications. Emergency CT examination can also be performed in unexplained coma...
September 8, 1983: La Semaine des Hôpitaux: Organe Fondé Par L'Association D'enseignement Médical des Hôpitaux de Paris
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