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Kevin Wilk

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https://www.readbyqxmd.com/read/27871658/rehabilitation-principles-of-the-anterior-cruciate-ligament-reconstructed-knee-twelve-steps-for-successful-progression-and-return-to-play
#1
REVIEW
Kevin E Wilk, Christopher A Arrigo
The rehabilitation process begins immediately after injury to the anterior cruciate ligament (ACL). The goal of preoperative rehabilitation is to prepare the patient for surgery. Current rehabilitation programs focus on strengthening exercises and proprioceptive and neuromuscular control drills to provide a neurologic stimulus. It is also important to address preexisting factors, especially for the female athlete, that may predispose to future injury, such as hip and hamstring weakness. Our goal in the rehabilitation program is to restore full, unrestricted function and to assist the patient to return to 100% of the preinjury level while achieving excellent long-term outcomes...
January 2017: Clinics in Sports Medicine
https://www.readbyqxmd.com/read/27556235/sensitivity-and-specificity-of-normality-tests-and-consequences-on-reference-interval-accuracy-at-small-sample-size-a-computer-simulation-study
#2
Kevin Le Boedec
BACKGROUND: According to international guidelines, parametric methods must be chosen for RI construction when the sample size is small and the distribution is Gaussian. However, normality tests may not be accurate at small sample size. OBJECTIVES: The purpose of the study was to evaluate normality test performance to properly identify samples extracted from a Gaussian population at small sample sizes, and assess the consequences on RI accuracy of applying parametric methods to samples that falsely identified the parent population as Gaussian...
August 24, 2016: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/27226389/2016-consensus-statement-on-return-to-sport-from-the-first-world-congress-in-sports-physical-therapy-bern
#3
Clare L Ardern, Philip Glasgow, Anthony Schneiders, Erik Witvrouw, Benjamin Clarsen, Ann Cools, Boris Gojanovic, Steffan Griffin, Karim M Khan, Håvard Moksnes, Stephen A Mutch, Nicola Phillips, Gustaaf Reurink, Robin Sadler, Karin Grävare Silbernagel, Kristian Thorborg, Arnlaug Wangensteen, Kevin E Wilk, Mario Bizzini
Deciding when to return to sport after injury is complex and multifactorial-an exercise in risk management. Return to sport decisions are made every day by clinicians, athletes and coaches, ideally in a collaborative way. The purpose of this consensus statement was to present and synthesise current evidence to make recommendations for return to sport decision-making, clinical practice and future research directions related to returning athletes to sport. A half day meeting was held in Bern, Switzerland, after the First World Congress in Sports Physical Therapy...
July 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/26972270/rehabilitation-of-the-overhead-throwing-athlete-there-is-more-to-it-than-just-external-rotation-internal-rotation-strengthening
#4
REVIEW
Kevin E Wilk, Christopher A Arrigo, Todd R Hooks, James R Andrews
The repetitive nature of throwing manifests characteristic adaptive changes to the shoulder, scapulothoracic, and hip/pelvis complexes that result in a set of unique physical traits in the overhead throwing athlete. An effective rehabilitation program is dependent upon an accurate evaluation and differential diagnosis to determine the causative factors for the athlete's pathologic features. The treatment program should be individualized with specific strengthening and flexibility exercises to achieve the dynamic stability that is required for overhead function...
March 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/26703031/clinical-outcomes-of-osseointegrated-prosthetic-auricular-reconstruction-in-patients-with-a-compromised-ipsilateral-temporoparietal-fascial-flap
#5
Kevin J Zuo, Gordon H Wilkes
Patients with major ear deformities and associated compromise of the superficial temporal artery are poor candidates for autogenous ear reconstruction because of a tenuous ipsilateral temporoparietal fascial flap (TPFF). Osseointegrated prosthetic auricular reconstruction (OPAR) is an alternative to contralateral free TPFF microsurgical and autogenous reconstruction, but data on clinical outcomes are limited. The records of patients with ear loss or major deformity and a compromised ipsilateral TPFF who underwent OPAR from 1989 to 2013 were reviewed...
January 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/26686653/limiting-cholesterol-biosynthetic-flux-spontaneously-engages-type-i-ifn-signaling
#6
Autumn G York, Kevin J Williams, Joseph P Argus, Quan D Zhou, Gurpreet Brar, Laurent Vergnes, Elizabeth E Gray, Anjie Zhen, Nicholas C Wu, Douglas H Yamada, Cameron R Cunningham, Elizabeth J Tarling, Moses Q Wilks, David Casero, David H Gray, Amy K Yu, Eric S Wang, David G Brooks, Ren Sun, Scott G Kitchen, Ting-Ting Wu, Karen Reue, Daniel B Stetson, Steven J Bensinger
Cellular lipid requirements are achieved through a combination of biosynthesis and import programs. Using isotope tracer analysis, we show that type I interferon (IFN) signaling shifts the balance of these programs by decreasing synthesis and increasing import of cholesterol and long chain fatty acids. Genetically enforcing this metabolic shift in macrophages is sufficient to render mice resistant to viral challenge, demonstrating the importance of reprogramming the balance of these two metabolic pathways in vivo...
December 17, 2015: Cell
https://www.readbyqxmd.com/read/26656948/the-mg-rast-metagenomics-database-and-portal-in-2015
#7
Andreas Wilke, Jared Bischof, Wolfgang Gerlach, Elizabeth Glass, Travis Harrison, Kevin P Keegan, Tobias Paczian, William L Trimble, Saurabh Bagchi, Ananth Grama, Somali Chaterji, Folker Meyer
MG-RAST (http://metagenomics.anl.gov) is an open-submission data portal for processing, analyzing, sharing and disseminating metagenomic datasets. The system currently hosts over 200,000 datasets and is continuously updated. The volume of submissions has increased 4-fold over the past 24 months, now averaging 4 terabasepairs per month. In addition to several new features, we report changes to the analysis workflow and the technologies used to scale the pipeline up to the required throughput levels. To show possible uses for the data from MG-RAST, we present several examples integrating data and analyses from MG-RAST into popular third-party analysis tools or sequence alignment tools...
January 4, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/26614470/the-painful-long-head-of-the-biceps-brachii-nonoperative-treatment-approaches
#8
REVIEW
Kevin E Wilk, Todd R Hooks
The long head of the biceps has garnered increased attention and interest due to the high prevalence of pain that can be a primary condition or occur secondary to shoulder dysfunction. The successful treatment of biceps tendinopathy is dependent on an accurate diagnosis and recognizing all causative factors. The treatment program will be individualized with a rehabilitation program designed to restore strength and flexibility and restore normal tendon mechanics.
January 2016: Clinics in Sports Medicine
https://www.readbyqxmd.com/read/26424574/anterior-cruciate-ligament-injury-prevention-and-rehabilitation-let-s-get-it-right
#9
EDITORIAL
Kevin E Wilk
Anterior cruciate ligament (ACL) injuries are among the most common and functionally disabling conditions in orthopaedics and sports medicine. As professionals, we need to do a better job of screening individuals to determine who is at greatest risk of sustaining an ACL injury, as well as implementing injury prevention programs. We also need to do a better job with programs that return individuals to their preinjury activity levels, including implementing thorough functional testing to determine if a patient is ready to return to sports or strenuous activities post-ACLR...
October 2015: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/26378893/targeting-inhibitor-of-apoptosis-proteins-protects-from-bleomycin-induced-lung-fibrosis
#10
Shanna L Ashley, Thomas H Sisson, Amanda K Wheaton, Kevin K Kim, Carol A Wilke, Iyabode O Ajayi, Natalya Subbotina, Shaomeng Wang, Colin S Duckett, Bethany B Moore, Jeffrey C Horowitz
Accumulation of apoptosis-resistant fibroblasts is a hallmark of pulmonary fibrosis. We hypothesized that disruption of inhibitor of apoptosis protein (IAP) family proteins would limit lung fibrosis. We first show that transforming growth factor-β1 and bleomycin increase X-linked IAP (XIAP) and cellular IAP (cIAP)-1 and -2 in murine lungs and mesenchymal cells. Functional blockade of XIAP and the cIAPs with AT-406, an orally bioavailable second mitochondria-derived activator of caspases (Smac) mimetic, abrogated bleomycin-induced lung fibrosis when given both prophylactically and therapeutically...
April 2016: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/26272516/deficits-in-glenohumeral-passive-range-of-motion-increase-risk-of-shoulder-injury-in-professional-baseball-pitchers-a-prospective-study
#11
Kevin E Wilk, Leonard C Macrina, Glenn S Fleisig, Kyle T Aune, Ron A Porterfield, Paul Harker, Timothy J Evans, James R Andrews
BACKGROUND: Shoulder injuries from repetitive baseball pitching continue to be a serious, common problem. PURPOSE: To determine whether passive range of motion of the glenohumeral joint was predictive of shoulder injury or shoulder surgery in professional baseball pitchers. STUDY DESIGN: Cohort study; Level of evidence, 2. METHODS: Passive range of motion of the glenohumeral joint was assessed with a bubble goniometer during spring training for all major and minor league pitchers of a single professional baseball organization over a period of 8 successive seasons (2005-2012)...
October 2015: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/26091920/a-novel-intravaginal-ring-to-prevent-hiv-1-hsv-2-hpv-and-unintended-pregnancy
#12
Shweta R Ugaonkar, Asa Wesenberg, Jolanta Wilk, Samantha Seidor, Olga Mizenina, Larisa Kizima, Aixa Rodriguez, Shimin Zhang, Keith Levendosky, Jessica Kenney, Meropi Aravantinou, Nina Derby, Brooke Grasperge, Agegnehu Gettie, James Blanchard, Narender Kumar, Kevin Roberts, Melissa Robbiani, José A Fernández-Romero, Thomas M Zydowsky
Women urgently need a self-initiated, multipurpose prevention technology (MPT) that simultaneously reduces their risk of acquiring HIV-1, HSV-2, and HPV (latter two associated with increased risk of HIV-1 acquisition) and prevents unintended pregnancy. Here, we describe a novel core-matrix intravaginal ring (IVR), the MZCL IVR, which effectively delivered the MZC combination microbicide and a contraceptive. The MZCL IVR contains four active pharmaceutical ingredients (APIs): MIV-150 (targets HIV-1), zinc acetate (ZA; targets HIV-1 and HSV-2), carrageenan (CG; targets HPV and HSV-2), and levonorgestrel (LNG; targets unintended pregnancy)...
September 10, 2015: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/26069540/rehabilitation-following-microfracture-of-the-knee
#13
Kevin E Wilk, Leonard C Macrina, Michael M Reinold
Postoperative rehabilitation programs following articular cartilage repair procedures will vary greatly among patients and need to be individualized based on the nature of the lesion, the unique characteristics of the patient, and the type and detail of each surgical procedure. These programs are based on knowledge of the basic science, anatomy, and biomechanics of articular cartilage as well as the biological course of healing following surgery. The goal is to restore full function in each patient as quickly as possible by facilitating a healing response without overloading the healing articular cartilage...
April 2010: Cartilage
https://www.readbyqxmd.com/read/26031498/workings-of-the-human-spirit-in-palliative-care-situations-a-consensus-model-from-the-chaplaincy-research-consortium
#14
Linda Emanuel, George Handzo, George Grant, Kevin Massey, Angelika Zollfrank, Diana Wilke, Richard Powell, Walter Smith, Kenneth Pargament
BACKGROUND: Chaplaincy is a relatively new discipline in medicine that provides for care of the human spirit in healthcare contexts for people of all worldviews. Studies indicate wide appreciation for its importance, yet empirical research is limited. Our purpose is to create a model of human spiritual processes and needs in palliative care situations so that researchers can locate their hypotheses in a common model which will evolve with relevant findings. METHODS: The Model Building Subgroup worked with the Chaplaincy Research Consortium as part of a larger Templeton Foundation funded project to enhance research in the area...
2015: BMC Palliative Care
https://www.readbyqxmd.com/read/25925603/prevalence-of-ulnar-collateral-ligament-surgery-in-professional-baseball-players
#15
Stan A Conte, Glenn S Fleisig, Joshua S Dines, Kevin E Wilk, Kyle T Aune, Nancy Patterson-Flynn, Neal ElAttrache
BACKGROUND: While the high rate of ulnar collateral ligament (UCL) injuries in professional baseball is widely discussed in the media and medical literature, the actual prevalence of UCL reconstruction has not been documented. HYPOTHESIS: The prevalence of UCL reconstruction will be higher among pitchers than nonpitchers, and Major League Baseball (MLB) pitchers will have a higher prevalence than will minor league pitchers. STUDY DESIGN: Descriptive epidemiology study...
July 2015: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/25909945/probability-of-return-of-spontaneous-circulation-as-a-function-of-timing-of-vasopressor-administration-in-out-of-hospital-cardiac-arrest
#16
COMPARATIVE STUDY
Michael W Hubble, Christopher Johnson, Jamie Blackwelder, Kevin Collopy, Sara Houston, Melisa Martin, Delbert Wilkes, Jonina Wiser
INTRODUCTION: Vasopressors (epinephrine and vasopressin) are associated with return of spontaneous circulation (ROSC). Recent retrospective studies reported a greater likelihood of ROSC when vasopressors were administered within the first 10 minutes of arrest. However, it is unlikely that the relationship between ROSC and the timing of vasopressor administration is a binary function (i.e., ≤10 vs. >10 minutes). More likely, this relationship is a function of time measured on a continuum, with diminishing effectiveness even within the first 10 minutes of arrest, and potentially, some lingering benefit beyond 10 minutes...
2015: Prehospital Emergency Care
https://www.readbyqxmd.com/read/25818712/rehabilitation-of-the-throwing-athlete-where-we-are-in-2014
#17
REVIEW
Kevin E Wilk, Todd R Hooks
The overhead athlete has unique physical traits and adaptive changes as a result of the repetitive nature of throwing. An effective rehabilitation program depends on an accurate evaluation to determine the causative factors for an athlete's pathology. A treatment program is individualized with specific strengthening and flexibility exercises to achieve dynamic stability that is required for overhead function. In this article the characteristics of the throwing shoulder and specific injuries are described. The rehabilitation program is described in a multiphased approach that allows for the restoration of strength, mobility, endurance, and power to return to sporting activity...
April 2015: Clinics in Sports Medicine
https://www.readbyqxmd.com/read/25618548/international-stakeholder-network-istnet-creating-a-developmental-neurotoxicity-dnt-testing-road-map-for-regulatory-purposes
#18
Anna Bal-Price, Kevin M Crofton, Marcel Leist, Sandra Allen, Michael Arand, Timo Buetler, Nathalie Delrue, Rex E FitzGerald, Thomas Hartung, Tuula Heinonen, Helena Hogberg, Susanne Hougaard Bennekou, Walter Lichtensteiger, Daniela Oggier, Martin Paparella, Marta Axelstad, Aldert Piersma, Eva Rached, Benoît Schilter, Gabriele Schmuck, Luc Stoppini, Enrico Tongiorgi, Manuela Tiramani, Florianne Monnet-Tschudi, Martin F Wilks, Timo Ylikomi, Ellen Fritsche
A major problem in developmental neurotoxicity (DNT) risk assessment is the lack of toxicological hazard information for most compounds. Therefore, new approaches are being considered to provide adequate experimental data that allow regulatory decisions. This process requires a matching of regulatory needs on the one hand and the opportunities provided by new test systems and methods on the other hand. Alignment of academically and industrially driven assay development with regulatory needs in the field of DNT is a core mission of the International STakeholder NETwork (ISTNET) in DNT testing...
February 2015: Archives of Toxicology
https://www.readbyqxmd.com/read/25614165/oral-immunotherapy-with-type-v-collagen-in-idiopathic-pulmonary-fibrosis
#19
MULTICENTER STUDY
David S Wilkes, Terrence Chew, Kevin R Flaherty, Sarah Frye, Kevin F Gibson, Naftali Kaminski, Michael J Klemsz, Wade Lange, Imre Noth, Katia Rothhaar
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis. IPF appears to be heterogeneous in pathobiology with ∼40% of IPF patients found to have elevated levels of circulating antibodies to the autoantigen type V collagen (col(V)). Following a targeted, precision medicine approach, we conducted a phase 1 study to test the safety and explore potential efficacy of IW001, a col(V) oral immunotherapeutic developed to treat antibody-positive IPF patients. We divided 30 antibody-positive IPF patients into three cohorts for daily dosing over a 24-week period...
May 2015: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/25174955/we-can-do-better
#20
EDITORIAL
Kevin E Wilk
No abstract text is available yet for this article.
September 2014: Journal of Orthopaedic and Sports Physical Therapy
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