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Kevin Wilk

Kevin E Wilk, Christopher A Arrigo
There are numerous complications that can occur following a musculoskeletal injury or surgery in the sporting population. Prevention of the most frequent complications is the key in any successful rehabilitation program, but occasionally problems do occur. A thorough well-designed postoperative or postinjury rehabilitation program may prevent these problems. However, if complications do arise, a team approach among the parties involved in the process to develop an evidenced-based treatment program designed for the underlying complication can successfully treat these issues...
April 2018: Clinics in Sports Medicine
Christo P Christov, Kevin S Dingwell, Mark Skehel, Helen S Wilkes, Julian E Sale, James C Smith, Torsten Krude
DNA replication in the embryo of Xenopus laevis changes dramatically at the mid-blastula transition (MBT), with Y RNA-independent random initiation switching to Y RNA-dependent initiation at specific origins. Here, we identify xNuRD, an MTA2-containing assemblage of the nucleosome remodeling and histone deacetylation complex NuRD, as an essential factor in pre-MBT Xenopus embryos that overcomes a functional requirement for Y RNAs during DNA replication. Human NuRD complexes have a different subunit composition than xNuRD and do not support Y RNA-independent initiation of DNA replication...
February 27, 2018: Cell Reports
Anna Bal-Price, Helena T Hogberg, Kevin M Crofton, Mardas Daneshian, Rex E FitzGerald, Ellen Fritsche, Tuula Heinonen, Susanne Hougaard Bennekou, Stefanie Klima, Aldert H Piersma, Magdalini Sachana, Timothy J Shafer, Andrea Terron, Florianne Monnet-Tschudi, Barbara Viviani, Tanja Waldmann, Remco H S Westerink, Martin F Wilks, Hilda Witters, Marie-Gabrielle Zurich, Marcel Leist
Multiple non-animal-based test methods have never been formally validated. In order to use such new approach methods (NAMs) in a regulatory context, criteria to define their readiness are necessary. The field of developmental neurotoxicity (DNT) testing is used to exemplify the application of readiness criteria. The costs and number of untested chemicals are overwhelming for in vivo DNT testing. Thus, there is a need for inexpensive, high-throughput NAMs, to obtain initial information on potential hazards, and to allow prioritization for further testing...
February 23, 2018: ALTEX
Ellen Fritsche, Philippe Grandjean, Kevin M Crofton, Michael Aschner, Alan Goldberg, Tuula Heinonen, Ellen V S Hessel, Helena Hogberg, Susanne Hougaard Bennekou, Pamela J Lein, Marcel Leist, William R Mundy, Martin Paparella, Aldert H Piersma, Magdalini Sachana, Gabriele Schmuck, Roland Solecki, Andrea Terron, Florianne Monnet-Tschudi, Martin F Wilks, Hilda Witters, Marie-Gabrielle Zurich, Anna Bal-Price
This consensus statement voices the agreement of scientific stakeholders from regulatory agencies, academia and industry that a new framework needs adopting for assessment of chemicals with the potential to disrupt brain development. An increased prevalence of neurodevelopmental disorders in children has been observed that cannot solely be explained by genetics and recently pre- and postnatal exposure to environmental chemicals has been suspected as a causal factor. There is only very limited information on neurodevelopmental toxicity, leaving thousands of chemicals, that are present in the environment, with high uncertainty concerning their developmental neurotoxicity (DNT) potential...
February 12, 2018: Toxicology and Applied Pharmacology
Karla Esbona, Yanyao Yi, Sandeep Saha, Menggang Yu, Rachel R Van Doorn, Matthew W Conklin, Douglas S Graham, Kari B Wisinski, Suzanne M Ponik, Kevin W Eliceiri, Lee G Wilke, Patricia J Keely
Inflammation, and the organization of collagen in the breast tumor microenvironment, is an important mediator of breast tumor progression. However, a direct link between markers of inflammation, collagen organization, and patient outcome has yet to be established. A tumor microarray of 371 invasive breast carcinoma biopsy specimens was analyzed for expression of inflammatory markers, including cyclooxygenase 2 (COX-2), macrophages, and several collagen features in the tumor nest (TN) or the tumor-associated stroma (TS)...
February 3, 2018: American Journal of Pathology
Ellyse Cipolla, Amanda J Fisher, Hongmei Gu, Elizabeth A Mickler, Manisha Agarwal, Carol A Wilke, Kevin K Kim, Bethany B Moore, Ragini Vittal
Interleukin 17A (IL-17A) and complement (C') activation have each been implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF). We have reported that IL-17A induces epithelial injury via TGF-β in murine bronchiolitis obliterans; that TGF-β and the C' cascade present signaling interactions in mediating epithelial injury; and that the blockade of C' receptors mitigates lung fibrosis. In the present study, we investigated the role of IL-17A in regulating C' in lung fibrosis. Microarray analyses of mRNA isolated from primary normal human small airway epithelial cells indicated that IL-17A (100 ng/ml; 24 h; n = 5 donor lungs) induces C' components (C' factor B, C3 , and GPCR kinase isoform 5), cytokines ( IL8 , -6 , and -1B ), and cytokine ligands ( CXCL1 , -2 , -3 , -5 , -6 , and -16 )...
December 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Kevin A Hinkle, Jacob Wilkes, Molly McFadden, Richard V Williams, LuAnn L Minich, Shaji C Menon
The few studies evaluating data on resource utilisation following the Fontan operation specifically are outdated. We sought to evaluate resource utilisation and factors associated with increased resource use after the Fontan operation in a contemporary, large, multi-institutional cohort. This retrospective cohort study of children who had the Fontan between January, 2004 and June, 2013 used the Pediatric Health Information Systems Database. Generalised linear regression analyses evaluated factors associated with resource use...
May 2017: Cardiology in the Young
Ellen Fritsche, Kevin M Crofton, Antonio F Hernandez, Susanne Hougaard Bennekou, Marcel Leist, Anna Bal-Price, Elissa Reaves, Martin F Wilks, Andrea Terron, Roland Solecki, Anne Gourmelon
No abstract text is available yet for this article.
2017: ALTEX
Kevin E Wilk, Kurt P Spindler, Eric McCarty, Dustin Grooms, Karin Grävare Silbernagel
Anterior cruciate ligament (ACL) reconstruction is a common and predominantly successful surgical intervention. But are there specific preoperative patient characteristics or intraoperative surgeon decisions that lead to better or worse outcomes? And can understanding brain function changes of patients after ACL reconstruction reveal insights into the ways that postsurgical rehabilitation can be improved to further enhance outcomes? These intriguing and clinically applicable questions are addressed in this webinar titled "Improving ACL Reconstruction Outcomes," hosted jointly by JOSPT and JBJS...
March 2017: Journal of Orthopaedic and Sports Physical Therapy
Clare L Ardern, Philip Glasgow, Anthony G Schneiders, Erik Witvrouw, Benjamin Clarsen, Ann Mj Cools, Boris Gojanovic, Steffan Griffin, Karim Khan, Håvard Moksnes, Stephen Mutch, Nicola Phillips, Guus Reurink, Robin Sadler, Karin Gravare Silbernagel, Kristian Thorborg, Arnlaug Wangensteen, Kevin Wilk, Mario Bizzini
No abstract text is available yet for this article.
February 17, 2017: British Journal of Sports Medicine
Chelsey M Wilkes, Karla T Washington, William M Palmer, Debra Parker Oliver, George Demiris, Kevin Craig
OBJECTIVE: Researchers sought to determine the extent to which burden related to patients' symptom subtypes could predict informal hospice caregiver depression, and to illustrate the differences between caregivers who experience suicidal ideation and those who do not. METHOD: Informal caregivers recruited from a not-for-profit community-based hospice agency participated in a cross-sectional survey. Self-report questionnaires assessed caregiver burden associated with patient symptomatology (via a modified version of the Memorial Symptom Assessment Scale-Short Form) and caregiver depressive symptoms, including suicidal ideation (measured by the Patient Health Questionnaire-9)...
January 31, 2017: Palliative & Supportive Care
J Kevin Wilkes, Charles D Fraser, Thomas J Seery
Atrioventricular septal defects represent a class of congenital cardiac malformations that vary in presentation and management strategy depending upon the severity of the particular lesions present. We present the case of a premature neonate who had a partial atrioventricular septal defect and an accessory mitral (or left atrioventricular) valve leaflet. The latter caused severe left ventricular outflow tract obstruction and severely depressed left ventricular function. We found only one other report of this atrioventricular valve abnormality in association with atrioventricular septal defect...
December 2016: Texas Heart Institute Journal
Kevin E Wilk, Christopher A Arrigo
The rehabilitation process begins immediately after injury to the anterior cruciate ligament (ACL). The goal of preoperative rehabilitation is to prepare the patient for surgery. Current rehabilitation programs focus on strengthening exercises and proprioceptive and neuromuscular control drills to provide a neurologic stimulus. It is also important to address preexisting factors, especially for the female athlete, that may predispose to future injury, such as hip and hamstring weakness. Our goal in the rehabilitation program is to restore full, unrestricted function and to assist the patient to return to 100% of the preinjury level while achieving excellent long-term outcomes...
January 2017: Clinics in Sports Medicine
Kevin Le Boedec
BACKGROUND: According to international guidelines, parametric methods must be chosen for RI construction when the sample size is small and the distribution is Gaussian. However, normality tests may not be accurate at small sample size. OBJECTIVES: The purpose of the study was to evaluate normality test performance to properly identify samples extracted from a Gaussian population at small sample sizes, and assess the consequences on RI accuracy of applying parametric methods to samples that falsely identified the parent population as Gaussian...
December 2016: Veterinary Clinical Pathology
Clare L Ardern, Philip Glasgow, Anthony Schneiders, Erik Witvrouw, Benjamin Clarsen, Ann Cools, Boris Gojanovic, Steffan Griffin, Karim M Khan, Håvard Moksnes, Stephen A Mutch, Nicola Phillips, Gustaaf Reurink, Robin Sadler, Karin Grävare Silbernagel, Kristian Thorborg, Arnlaug Wangensteen, Kevin E Wilk, Mario Bizzini
Deciding when to return to sport after injury is complex and multifactorial-an exercise in risk management. Return to sport decisions are made every day by clinicians, athletes and coaches, ideally in a collaborative way. The purpose of this consensus statement was to present and synthesise current evidence to make recommendations for return to sport decision-making, clinical practice and future research directions related to returning athletes to sport. A half day meeting was held in Bern, Switzerland, after the First World Congress in Sports Physical Therapy...
July 2016: British Journal of Sports Medicine
Kevin E Wilk, Christopher A Arrigo, Todd R Hooks, James R Andrews
The repetitive nature of throwing manifests characteristic adaptive changes to the shoulder, scapulothoracic, and hip/pelvis complexes that result in a set of unique physical traits in the overhead throwing athlete. An effective rehabilitation program is dependent upon an accurate evaluation and differential diagnosis to determine the causative factors for the athlete's pathologic features. The treatment program should be individualized with specific strengthening and flexibility exercises to achieve the dynamic stability that is required for overhead function...
March 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
Kevin J Zuo, Gordon H Wilkes
Patients with major ear deformities and associated compromise of the superficial temporal artery are poor candidates for autogenous ear reconstruction because of a tenuous ipsilateral temporoparietal fascial flap (TPFF). Osseointegrated prosthetic auricular reconstruction (OPAR) is an alternative to contralateral free TPFF microsurgical and autogenous reconstruction, but data on clinical outcomes are limited. The records of patients with ear loss or major deformity and a compromised ipsilateral TPFF who underwent OPAR from 1989 to 2013 were reviewed...
January 2016: Journal of Craniofacial Surgery
Autumn G York, Kevin J Williams, Joseph P Argus, Quan D Zhou, Gurpreet Brar, Laurent Vergnes, Elizabeth E Gray, Anjie Zhen, Nicholas C Wu, Douglas H Yamada, Cameron R Cunningham, Elizabeth J Tarling, Moses Q Wilks, David Casero, David H Gray, Amy K Yu, Eric S Wang, David G Brooks, Ren Sun, Scott G Kitchen, Ting-Ting Wu, Karen Reue, Daniel B Stetson, Steven J Bensinger
Cellular lipid requirements are achieved through a combination of biosynthesis and import programs. Using isotope tracer analysis, we show that type I interferon (IFN) signaling shifts the balance of these programs by decreasing synthesis and increasing import of cholesterol and long chain fatty acids. Genetically enforcing this metabolic shift in macrophages is sufficient to render mice resistant to viral challenge, demonstrating the importance of reprogramming the balance of these two metabolic pathways in vivo...
December 17, 2015: Cell
Andreas Wilke, Jared Bischof, Wolfgang Gerlach, Elizabeth Glass, Travis Harrison, Kevin P Keegan, Tobias Paczian, William L Trimble, Saurabh Bagchi, Ananth Grama, Somali Chaterji, Folker Meyer
MG-RAST ( is an open-submission data portal for processing, analyzing, sharing and disseminating metagenomic datasets. The system currently hosts over 200,000 datasets and is continuously updated. The volume of submissions has increased 4-fold over the past 24 months, now averaging 4 terabasepairs per month. In addition to several new features, we report changes to the analysis workflow and the technologies used to scale the pipeline up to the required throughput levels. To show possible uses for the data from MG-RAST, we present several examples integrating data and analyses from MG-RAST into popular third-party analysis tools or sequence alignment tools...
January 4, 2016: Nucleic Acids Research
Kevin E Wilk, Todd R Hooks
The long head of the biceps has garnered increased attention and interest due to the high prevalence of pain that can be a primary condition or occur secondary to shoulder dysfunction. The successful treatment of biceps tendinopathy is dependent on an accurate diagnosis and recognizing all causative factors. The treatment program will be individualized with a rehabilitation program designed to restore strength and flexibility and restore normal tendon mechanics.
January 2016: Clinics in Sports Medicine
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